{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T04:19:45Z","timestamp":1787631585295,"version":"build-2736575974"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T00:00:00Z","timestamp":1762473600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T00:00:00Z","timestamp":1762473600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China,China","doi-asserted-by":"crossref","award":["82100753"],"award-info":[{"award-number":["82100753"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82400796"],"award-info":[{"award-number":["82400796"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Excellent Young Doctoral Training Program of Jiangsu Province Hospital of Chinese Medicine","award":["2024QB023"],"award-info":[{"award-number":["2024QB023"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Inflammation"],"DOI":"10.1007\/s10753-025-02349-7","type":"journal-article","created":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T01:57:07Z","timestamp":1762480627000},"page":"4591-4607","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["HNRNPC-Mediated m6A Epitranscriptomics Drives CD80-Dependent Tubular Dysfunction in Sepsis-Induced AKI"],"prefix":"10.1007","volume":"48","author":[{"given":"Chenxia","family":"Juan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangling","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuejuan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Duqun","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manshu","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Mao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,11,7]]},"reference":[{"issue":"3","key":"2349_CR1","doi-asserted-by":"publisher","first-page":"498","DOI":"10.1016\/j.kint.2020.08.039","volume":"99","author":"IH de Boer","year":"2021","unstructured":"de Boer, I.H., et al. 2021. Rationale and design of the Kidney Precision Medicine Project. Kidney International 99 (3): 498\u2013510.","journal-title":"Kidney International"},{"issue":"4","key":"2349_CR2","doi-asserted-by":"publisher","first-page":"508","DOI":"10.1053\/j.ajkd.2019.11.010","volume":"75","author":"IE McCoy","year":"2020","unstructured":"McCoy, I.E., and G.M. Chertow. 2020. AKI-a relevant safety end point? American Journal of Kidney Diseases 75 (4): 508\u2013512.","journal-title":"American Journal of Kidney Diseases"},{"issue":"12","key":"2349_CR3","doi-asserted-by":"publisher","first-page":"1838","DOI":"10.2215\/CJN.15611219","volume":"15","author":"KD Liu","year":"2020","unstructured":"Liu, K.D., et al. 2020. AKI!Now initiative: Recommendations for awareness, recognition, and management of AKI. Clinical Journal of the American Society of Nephrology 15 (12): 1838\u20131847.","journal-title":"Clinical Journal of the American Society of Nephrology"},{"issue":"3","key":"2349_CR4","doi-asserted-by":"publisher","first-page":"1011","DOI":"10.1681\/ASN.2017060694","volume":"29","author":"M Meersch","year":"2018","unstructured":"Meersch, M., et al. 2018. Long-term clinical outcomes after early initiation of RRT in critically ill patients with AKI. Journal of the American Society of Nephrology 29 (3): 1011\u20131019.","journal-title":"Journal of the American Society of Nephrology"},{"issue":"1","key":"2349_CR5","doi-asserted-by":"publisher","first-page":"30","DOI":"10.2215\/CJN.01290215","volume":"11","author":"KV Liang","year":"2016","unstructured":"Liang, K.V., et al. 2016. Modality of RRT and recovery of kidney function after AKI in patients surviving to hospital discharge. Clinical Journal of the American Society of Nephrology 11 (1): 30\u201338.","journal-title":"Clinical Journal of the American Society of Nephrology"},{"issue":"9","key":"2349_CR6","doi-asserted-by":"publisher","first-page":"2712","DOI":"10.7150\/thno.31424","volume":"9","author":"L Xu","year":"2019","unstructured":"Xu, L., et al. 2019. EGFR drives the progression of AKI to CKD through HIPK2 overexpression. Theranostics 9 (9): 2712\u20132726.","journal-title":"Theranostics"},{"issue":"5","key":"2349_CR7","doi-asserted-by":"publisher","first-page":"1071","DOI":"10.1016\/j.kint.2017.06.030","volume":"92","author":"L He","year":"2017","unstructured":"He, L., et al. 2017. AKI on CKD: Heightened injury, suppressed repair, and the underlying mechanisms. Kidney International 92 (5): 1071\u20131083.","journal-title":"Kidney International"},{"issue":"1","key":"2349_CR8","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1681\/ASN.2015060670","volume":"28","author":"J Chen","year":"2017","unstructured":"Chen, J., et al. 2017. IkappaB kinase inhibitor attenuates sepsis-induced cardiac dysfunction in CKD. Journal of the American Society of Nephrology 28 (1): 94\u2013105.","journal-title":"Journal of the American Society of Nephrology"},{"issue":"1","key":"2349_CR9","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-020-03424-1","volume":"25","author":"EC van der Slikke","year":"2021","unstructured":"van der Slikke, E.C., et al. 2021. Sepsis is associated with mitochondrial DNA damage and a reduced mitochondrial mass in the kidney of patients with sepsis-AKI. Critical Care 25 (1): 36.","journal-title":"Critical Care"},{"key":"2349_CR10","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20200829","author":"C Mapperley","year":"2021","unstructured":"Mapperley, C., et al. 2021. The mRNA m6A reader YTHDF2 suppresses proinflammatory pathways and sustains hematopoietic stem cell function. Journal of Experimental Medicine. https:\/\/doi.org\/10.1084\/jem.20200829.","journal-title":"Journal of Experimental Medicine"},{"issue":"1","key":"2349_CR11","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1096\/fj.201901555R","volume":"34","author":"C Zhang","year":"2020","unstructured":"Zhang, C., et al. 2020. METTL3 regulates inflammatory pain by modulating m(6)A-dependent pri-miR-365-3p processing. FASEB Journal 34 (1): 122\u2013132.","journal-title":"FASEB Journal"},{"key":"2349_CR12","doi-asserted-by":"publisher","first-page":"105286","DOI":"10.1016\/j.phrs.2020.105286","volume":"163","author":"JT Yu","year":"2021","unstructured":"Yu, J. T., et al. 2021. DNA methylation of FTO promotes renal inflammation by enhancing m(6)a of PPAR-alpha in alcohol-induced kidney injury. Pharmacological Research 163:105286.","journal-title":"Pharmacological Research"},{"issue":"10","key":"2349_CR13","doi-asserted-by":"publisher","first-page":"608","DOI":"10.1038\/s41580-019-0168-5","volume":"20","author":"S Zaccara","year":"2019","unstructured":"Zaccara, S., R.J. Ries, and S.R. Jaffrey. 2019. Reading, writing and erasing mRNA methylation. Nature Reviews Molecular Cell Biology 20 (10): 608\u2013624.","journal-title":"Nature Reviews Molecular Cell Biology"},{"issue":"7","key":"2349_CR14","doi-asserted-by":"publisher","first-page":"1582","DOI":"10.1016\/j.cell.2020.05.012","volume":"181","author":"S Zaccara","year":"2020","unstructured":"Zaccara, S., and S. R. Jaffrey. 2020. A unified model for the function of YTHDF proteins in regulating m(6)A-modified mRNA. Cell 181 (7): 1582-1595.e18.","journal-title":"Cell"},{"issue":"7540","key":"2349_CR15","doi-asserted-by":"publisher","first-page":"560","DOI":"10.1038\/nature14234","volume":"518","author":"N Liu","year":"2015","unstructured":"Liu, N., et al. 2015. N(6)-methyladenosine-dependent RNA structural switches regulate RNA-protein interactions. Nature 518 (7540): 560\u2013564.","journal-title":"Nature"},{"issue":"23","key":"2349_CR16","doi-asserted-by":"publisher","DOI":"10.15252\/embj.201899017","volume":"37","author":"Y Wu","year":"2018","unstructured":"Wu, Y., et al. 2018. Function of HNRNPC in breast cancer cells by controlling the dsRNA-induced interferon response. The EMBO Journal 37 (23): e99017.","journal-title":"The EMBO Journal"},{"issue":"10","key":"2349_CR17","doi-asserted-by":"publisher","first-page":"1164","DOI":"10.1111\/tri.13273","volume":"31","author":"CJ Rivard","year":"2018","unstructured":"Rivard, C.J., et al. 2018. Upregulation of CD80 on glomerular podocytes plays an important role in development of proteinuria following pig-to-baboon xeno-renal transplantation - An experimental study. Transplant International 31 (10): 1164\u20131177.","journal-title":"Transplant International"},{"issue":"1","key":"2349_CR18","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1093\/ndt\/gfr271","volume":"27","author":"M Shimada","year":"2012","unstructured":"Shimada, M., et al. 2012. Toll-like receptor 3 ligands induce CD80 expression in human podocytes via an NF-kappaB-dependent pathway. Nephrology, Dialysis, Transplantation 27 (1): 81\u201389.","journal-title":"Nephrology, Dialysis, Transplantation"},{"issue":"4","key":"2349_CR19","doi-asserted-by":"publisher","first-page":"F723","DOI":"10.1152\/ajprenal.00491.2018","volume":"316","author":"GS Netti","year":"2019","unstructured":"Netti, G.S., et al. 2019. LPS removal reduces CD80-mediated albuminuria in critically ill patients with Gram-negative sepsis. American Journal of Physiology-Renal Physiology 316 (4): F723\u2013F731.","journal-title":"American Journal of Physiology-Renal Physiology"},{"issue":"1","key":"2349_CR20","doi-asserted-by":"publisher","first-page":"430","DOI":"10.1161\/ATVBAHA.120.314639","volume":"41","author":"A Zawia","year":"2021","unstructured":"Zawia, A., et al. 2021. Altered macrophage polarization induces experimental pulmonary hypertension and is observed in patients with pulmonary arterial hypertension. Arteriosclerosis, Thrombosis, and Vascular Biology 41 (1): 430\u2013445.","journal-title":"Arteriosclerosis, Thrombosis, and Vascular Biology"},{"issue":"8","key":"2349_CR21","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-022-05157-1","volume":"13","author":"W Zhu","year":"2022","unstructured":"Zhu, W., et al. 2022. LncRNA CYTOR promotes aberrant glycolysis and mitochondrial respiration via HNRNPC-mediated ZEB1 stabilization in oral squamous cell carcinoma. Cell Death & Disease 13 (8): 703.","journal-title":"Cell Death & Disease"},{"issue":"672","key":"2349_CR22","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.abo5715","volume":"14","author":"F Martino","year":"2022","unstructured":"Martino, F., et al. 2022. The mechanical regulation of RNA binding protein hnRNPC in the failing heart. Science Translational Medicine 14 (672): eabo5715.","journal-title":"Science Translational Medicine"},{"issue":"5 Pt A","key":"2349_CR23","doi-asserted-by":"publisher","first-page":"822","DOI":"10.1016\/j.jmb.2015.08.021","volume":"428","author":"KI Zhou","year":"2016","unstructured":"Zhou, K.I., et al. 2016. N(6)-methyladenosine modification in a long noncoding RNA hairpin predisposes its conformation to protein binding. Journal of Molecular Biology 428 (5 Pt A): 822\u2013833.","journal-title":"Journal of Molecular Biology"},{"issue":"7","key":"2349_CR24","doi-asserted-by":"publisher","first-page":"1050","DOI":"10.2215\/CJN.00850122","volume":"17","author":"S Kuwabara","year":"2022","unstructured":"Kuwabara, S., E. Goggins, and M.D. Okusa. 2022. The pathophysiology of sepsis-associated AKI. Clinical Journal of the American Society of Nephrology 17 (7): 1050\u20131069.","journal-title":"Clinical Journal of the American Society of Nephrology"},{"issue":"4","key":"2349_CR25","doi-asserted-by":"publisher","first-page":"938","DOI":"10.3390\/cells9040938","volume":"9","author":"YH Lin","year":"2020","unstructured":"Lin, Y. H., et al. 2020. Interleukin 26 Skews Macrophage Polarization Towards M1 Phenotype by Activating cJUN and the NF-kappaB Pathway. Cells 9 (4): 938.","journal-title":"Cells"},{"key":"2349_CR26","doi-asserted-by":"publisher","first-page":"109772","DOI":"10.1016\/j.biopha.2019.109772","volume":"122","author":"Q Ren","year":"2020","unstructured":"Ren, Q., et al. 2020. Flavonoid fisetin alleviates kidney inflammation and apoptosis via inhibiting Src-mediated NF-kappaB p65 and MAPK signaling pathways in septic AKI mice. Biomedicine & Pharmacotherapy 122:109772.","journal-title":"Biomedicine & Pharmacotherapy"},{"issue":"2","key":"2349_CR27","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1016\/j.kint.2023.04.013","volume":"104","author":"S Li","year":"2023","unstructured":"Li, S., et al. 2023. Peroxiredoxin 1 aggravates acute kidney injury by promoting inflammation through Mincle\/Syk\/NF-kappaB signaling. Kidney International 104 (2): 305\u2013323.","journal-title":"Kidney International"},{"key":"2349_CR28","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1016\/j.cytogfr.2016.02.004","volume":"28","author":"N Porciello","year":"2016","unstructured":"Porciello, N., and L. Tuosto. 2016. CD28 costimulatory signals in T lymphocyte activation: Emerging functions beyond a qualitative and quantitative support to TCR signalling. Cytokine & Growth Factor Reviews 28:11\u201319.","journal-title":"Cytokine & Growth Factor Reviews"},{"issue":"1","key":"2349_CR29","doi-asserted-by":"publisher","first-page":"e2400614","DOI":"10.1002\/ardp.202400614","volume":"358","author":"F Maqueda-Zelaya","year":"2024","unstructured":"Maqueda-Zelaya, F., et al. 2024. Identification and study of new NF-kappaB-inducing kinase ligands derived from the imidazolone scaffold. Archiv der Pharmazie (Weinheim) 358 (1): e2400614.","journal-title":"Archiv der Pharmazie (Weinheim)"},{"key":"2349_CR30","doi-asserted-by":"crossref","unstructured":"Zhang, Q., et al. 2024. CSTF2 supports hypoxia tolerance in hepatocellular carcinoma by enabling m6A modification evasion of PGK1 to enhance glycolysis. Cancer Research 85(3): 515\u2013534","DOI":"10.1158\/0008-5472.CAN-24-2283"}],"container-title":["Inflammation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10753-025-02349-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10753-025-02349-7","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10753-025-02349-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,22]],"date-time":"2025-12-22T13:23:10Z","timestamp":1766409790000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10753-025-02349-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,7]]},"references-count":30,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["2349"],"URL":"https:\/\/doi.org\/10.1007\/s10753-025-02349-7","relation":{},"ISSN":["1573-2576"],"issn-type":[{"value":"1573-2576","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,7]]},"assertion":[{"value":"16 June 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 July 2025","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 July 2025","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 November 2025","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The animal study was approved by the Committee on the Ethics of Animal Experiments at Nanjing University of Chinese Medicine (2022NL-KS202).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics Approval and Consent to Participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for Publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}