{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,5]],"date-time":"2026-04-05T10:51:58Z","timestamp":1775386318073,"version":"3.50.1"},"reference-count":93,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T00:00:00Z","timestamp":1774224000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,4,5]],"date-time":"2026-04-05T00:00:00Z","timestamp":1775347200000},"content-version":"vor","delay-in-days":13,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Inflammation"],"DOI":"10.1007\/s10753-025-02367-5","type":"journal-article","created":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T23:11:42Z","timestamp":1774307502000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Long-Term Fructose Intake Induces Moderate Liver Inflammation but Does not Overlap with the Detrimental Effects of the Ketogenic Diet on Hepatic Steatosis in Rats"],"prefix":"10.1007","volume":"49","author":[{"given":"J\u00falia Galbiati","family":"de Souza","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Glaucivan Gomes","family":"Gurgel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fernanda Marques","family":"Rodrigues","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ribanna Aparecida Marques","family":"Braga","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosana Aparecida Man\u00f3lio","family":"Soares","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lu\u00eds Alberto de P\u00e1dua Covas","family":"Lage","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iber\u00ea Cauduro","family":"Soares","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D\u00e9bora","family":"Levy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N\u00e1gila Raquel Teixeira","family":"Damasceno","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2026,3,23]]},"reference":[{"key":"2367_CR1","doi-asserted-by":"publisher","first-page":"600","DOI":"10.1038\/s42255-024-00985-1","volume":"6","author":"Cynthia L Hsu","year":"2024","unstructured":"Hsu, Cynthia L., Rohit, and Loomba. 2024. From NAFLD to MASLD: Implications of the new nomenclature for preclinical and clinical research. Nature Metabolism 6:600\u2013602. https:\/\/doi.org\/10.1038\/s42255-024-00985-1","journal-title":"Nature Metabolism"},{"key":"2367_CR2","doi-asserted-by":"publisher","first-page":"1647","DOI":"10.1007\/s40200-021-00916-x","volume":"20","author":"Fatemeh Sadeghi","year":"2021","unstructured":"Sadeghi, Fatemeh, Sasan Amanat, Mohammad Bakhtiari, Hadis Asadimehr, Mohammad Ali Okhovat, Masood Hosseinzadeh, Seyed Mohammad Mazloomi, Maryam Gholamalizadeh, and Saeid Doaei. 2021. The effects of high fructose fruits and honey on the serum level of metabolic factors and nonalcoholic fatty liver disease. Journal of Diabetes & Metabolic Disorders 20: 1647\u20131654. https:\/\/doi.org\/10.1007\/s40200-021-00916-x.","journal-title":"Journal of Diabetes & Metabolic Disorders"},{"key":"2367_CR3","doi-asserted-by":"publisher","first-page":"683","DOI":"10.1016\/j.tem.2024.02.012","volume":"35","author":"Xiude Fan","year":"2024","unstructured":"Fan, Xiude, Yongfeng Song, and Jiajun Zhao. 2024. Evolving liver disease insights from NAFLD to MASLD. Trends in Endocrinology & Metabolism 35:683\u2013686. https:\/\/doi.org\/10.1016\/j.tem.2024.02.012","journal-title":"Trends in Endocrinology & Metabolism"},{"key":"2367_CR4","doi-asserted-by":"publisher","first-page":"109402","DOI":"10.1016\/j.jnutbio.2023.109402","volume":"119","author":"Xin Jiang","year":"2023","unstructured":"Jiang, Xin, Ruixiang Hu, Yipu Huang, Yi. Xu, Zhirui Zheng, Yuansen Shi, Ji. Miao, and Yun Liu. 2023. Fructose aggravates copper-deficiency-induced non-alcoholic fatty liver disease. Journal of Nutritional Biochemistry 119: 109402. https:\/\/doi.org\/10.1016\/j.jnutbio.2023.109402.","journal-title":"Journal of Nutritional Biochemistry"},{"key":"2367_CR5","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2019-036663","volume":"10","author":"Xiaojun Ge","year":"2020","unstructured":"Ge, Xiaojun, Limei Zheng, Mei Wang, Yuxuan Du, and Junyao Jiang. 2020. Prevalence trends in non-alcoholic fatty liver disease at the global, regional and national levels, 1990\u20132017: A population-based observational study. BMJ Open 10: e036663. https:\/\/doi.org\/10.1136\/bmjopen-2019-036663.","journal-title":"BMJ Open"},{"key":"2367_CR6","doi-asserted-by":"publisher","first-page":"921","DOI":"10.1007\/s00392-020-01709-7","volume":"110","author":"Philipp Kasper","year":"2021","unstructured":"Kasper, Philipp, Anna Martin, Sonja Lang, Fabian K\u00fctting, Tobias Goeser, and M\u00fcnevver Demir, Hans-Michael Steffen. 2021. NAFLD and cardiovascular diseases: A clinical review. Clinical Research in Cardiology 110:921\u2013937. https:\/\/doi.org\/10.1007\/s00392-020-01709-7","journal-title":"Clinical Research in Cardiology"},{"key":"2367_CR7","doi-asserted-by":"publisher","first-page":"589","DOI":"10.1016\/j.jhep.2016.05.013","volume":"65","author":"Giovanni Targher","year":"2016","unstructured":"Targher, Giovanni, Christopher D. Byrne, Amedeo Lonardo, Giacomo Zoppini, and Corrado Barbui. 2016. Non-alcoholic fatty liver disease and risk of incident cardiovascular disease: A meta-analysis. Journal of Hepatology 65:589\u2013600. https:\/\/doi.org\/10.1016\/j.jhep.2016.05.013","journal-title":"Journal of Hepatology"},{"key":"2367_CR8","doi-asserted-by":"publisher","first-page":"33386","DOI":"10.1038\/srep33386","volume":"6","author":"Shunquan Wu","year":"2016","unstructured":"Wu, Shunquan, Fuquan Wu, Yingying Ding, Jun Hou, Jingfeng Bi, and Zheng Zhang. 2016. Association of non-alcoholic fatty liver disease with major adverse cardiovascular events: A systematic review and meta-analysis. Scientific Reports 6:33386. https:\/\/doi.org\/10.1038\/srep33386","journal-title":"Scientific Reports"},{"key":"2367_CR9","doi-asserted-by":"publisher","first-page":"goae029","DOI":"10.1093\/gastro\/goae029","volume":"12","author":"Stefano Ciardullo","year":"2023","unstructured":"Ciardullo, Stefano, Emanuele Muraca, Michela Vergani, Pietro Invernizzi, Gianluca Perseghin. 2023. Advancements in pharmacological treatment of NAFLD\/MASLD: A focus on metabolic and liver-targeted interventions. Gastroenterology Report 12: goae029. https:\/\/doi.org\/10.1093\/gastro\/goae029.","journal-title":"Gastroenterology Report"},{"key":"2367_CR10","doi-asserted-by":"publisher","first-page":"3860","DOI":"10.3390\/nu12123860","volume":"12","author":"Marcela Parra-Vargas","year":"2020","unstructured":"Parra-Vargas, Marcela, C. Josep, and Jimenez-Chillaron. 2020. Nutritional approaches for the management of nonalcoholic fatty liver disease: An evidence-based review. Nutrients 12: 3860. https:\/\/doi.org\/10.3390\/nu12123860.","journal-title":"Nutrients"},{"key":"2367_CR11","doi-asserted-by":"publisher","first-page":"109174","DOI":"10.1016\/j.jnutbio.2022.109174","volume":"112","author":"Yuwen Luo","year":"2023","unstructured":"Luo, Yuwen, Lauren N. Woodie, Emily C. Graff, Jian Zhang, Savanah Fowler, Xiaozhu Wang, Xu Wang, O\u2019Neill Ann Marie, and Michael W. Greene. 2023. Role of liquid fructose\/sucrose in regulating the hepatic transcriptome in a high-fat Western diet model of NAFLD. The Journal of Nutritional Biochemistry 112:109174. https:\/\/doi.org\/10.1016\/j.jnutbio.2022.109174","journal-title":"The Journal of Nutritional Biochemistry"},{"key":"2367_CR12","doi-asserted-by":"publisher","first-page":"1178","DOI":"10.1038\/s42255-024-01043-6","volume":"6","author":"Michele Vacca","year":"2024","unstructured":"Vacca, Michele, Ioannis Kamzolas, Lea M\u00f8rch, Fiona Harder, Christian Oakley, Maximilian Trautwein, Trenton Hatting, and Ross et al. 2024. An unbiased ranking of murine dietary models based on their proximity to human metabolic dysfunction-associated steatotic liver disease (MASLD). Nature Metabolism 6:1178\u20131196. https:\/\/doi.org\/10.1038\/s42255-024-01043-6","journal-title":"Nature Metabolism"},{"key":"2367_CR13","doi-asserted-by":"publisher","first-page":"1376098","DOI":"10.3389\/fnut.2024.1376098","volume":"11","author":"Jeff S Volek","year":"2024","unstructured":"Volek, Jeff S., William S. Yancy, Barbara A. Gower, Stephen D. Phinney, Joanne Slavin, Andrew P. Koutnik, Michelle Hurn, Jovonni Spinner, Mark Cucuzzella, and Frederick M. Hecht. 2024. Expert consensus on nutrition and lower-carbohydrate diets: An evidence- and equity-based approach to dietary guidance. Frontiers in Nutrition 11:1376098. https:\/\/doi.org\/10.3389\/fnut.2024.1376098","journal-title":"Frontiers in Nutrition"},{"key":"2367_CR14","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1002\/lipd.12128","volume":"54","author":"Christine Feillet-Coudray","year":"2019","unstructured":"Feillet-Coudray, Christine, Gilles Fouret, Claire Vigor, B\u00e9atrice. Bonafos, Bernard Jover, Agnieszka Blachnio\u2010Zabielska, Jennifer Rieusset, et al. 2019. Long\u2010term measures of dyslipidemia, inflammation, and oxidative stress in rats fed a high\u2010fat\/high\u2010fructose diet. Lipids 54: 81\u201397. https:\/\/doi.org\/10.1002\/lipd.12128.","journal-title":"Lipids"},{"key":"2367_CR15","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1097\/MCO.0000000000000687","volume":"23","author":"Sion A Parry","year":"2020","unstructured":"Parry, Sion A., C. Mark, and Turner, Leanne Hodson. 2020. Lifestyle interventions affecting hepatic fatty acid metabolism. Current Opinion in Clinical Nutrition & Metabolic Care 23:373\u2013379. https:\/\/doi.org\/10.1097\/MCO.0000000000000687","journal-title":"Current Opinion in Clinical Nutrition & Metabolic Care"},{"key":"2367_CR16","doi-asserted-by":"publisher","first-page":"120751","DOI":"10.1016\/j.lfs.2022.120751","volume":"305","author":"Mohamed M Elseweidy","year":"2022","unstructured":"Elseweidy, Mohamed M., E. Ahmed, Mohammed S. Elesawy, Sobh, and Gehad M. Elnagar. 2022. Ellagic acid ameliorates high fructose-induced hyperuricemia and non-alcoholic fatty liver in Wistar rats: Focusing on the role of C1q\/tumor necrosis factor-related protein-3 and ATP citrate lyase. Life Sciences 305:120751. https:\/\/doi.org\/10.1016\/j.lfs.2022.120751","journal-title":"Life Sciences"},{"key":"2367_CR17","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2022.e10896","volume":"8","author":"Ika Yustisia","year":"2022","unstructured":"Yustisia, Ika, Delvina Tandiari, Muhammad Husni Cangara, Firdaus Hamid, and Nu.\u2019man As.. Daud. 2022. A high-fat, high-fructose diet induced hepatic steatosis, renal lesions, dyslipidemia, and hyperuricemia in non-obese rats. Heliyon 8: e10896. https:\/\/doi.org\/10.1016\/j.heliyon.2022.e10896.","journal-title":"Heliyon"},{"key":"2367_CR18","doi-asserted-by":"publisher","first-page":"1603","DOI":"10.1177\/0271678X15610584","volume":"36","author":"Tiffany Greco","year":"2016","unstructured":"Greco, Tiffany, Thomas C Glenn, David A Hovda, and L Prins Mayumi. 2016. Ketogenic diet decreases oxidative stress and improves mitochondrial respiratory complex activity. Journal of Cerebral Blood Flow & Metabolism 36:1603\u20131613. https:\/\/doi.org\/10.1177\/0271678X15610584","journal-title":"Journal of Cerebral Blood Flow & Metabolism"},{"key":"2367_CR19","volume-title":"Dr. Atkins\u2019 diet revolution: The High-Calorie way to stay thin forever","author":"RC Atkins","year":"1972","unstructured":"Atkins, R. C. 1972. Dr. Atkins\u2019 diet revolution: The High-Calorie way to stay thin forever. Nova York. NY. EUA.: McKay Co."},{"key":"2367_CR20","doi-asserted-by":"publisher","unstructured":"Martin-McGill, Kirsty, J., Robert G Rebecca Bresnahan, Levy, and N Cooper Paul. 2020. Ketogenic diets for drug-resistant epilepsy. Edited by Cochrane Epilepsy Group. Cochrane Database of Systematic Reviews 2020. https:\/\/doi.org\/10.1002\/14651858.CD001903.pub5","DOI":"10.1002\/14651858.CD001903.pub5"},{"key":"2367_CR21","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1007\/s11154-019-09514-y","volume":"21","author":"Marco Castellana","year":"2020","unstructured":"Castellana, Marco, Eleonora Conte, Angelo Cignarelli, Sebastio Perrini, Andrea Giustina, Luca Giovanella, and Francesco Giorgino, Pierpaolo Trimboli. 2020. Efficacy and safety of very low calorie ketogenic diet (VLCKD) in patients with overweight and obesity: A systematic review and meta-analysis. Reviews in Endocrine and Metabolic Disorders 21:5\u201316. https:\/\/doi.org\/10.1007\/s11154-019-09514-y","journal-title":"Reviews in Endocrine and Metabolic Disorders"},{"key":"2367_CR22","doi-asserted-by":"publisher","first-page":"13040","DOI":"10.3390\/ijerph192013040","volume":"19","author":"Claudia Di Rosa","year":"2022","unstructured":"Di Rosa, Claudia, Greta Lattanzi, Chiara Spiezia, Elena Imperia, Sara Piccirilli, Ivan Beato, Gianluigi Gaspa, et al. 2022. Mediterranean diet versus very low-calorie ketogenic diet: Effects of reaching 5% body weight loss on body composition in subjects with overweight and with obesity\u2014A cohort study. International Journal of Environmental Research and Public Health 19: 13040. https:\/\/doi.org\/10.3390\/ijerph192013040.","journal-title":"International Journal of Environmental Research and Public Health"},{"key":"2367_CR23","doi-asserted-by":"publisher","first-page":"640","DOI":"10.1093\/ajcn\/nqac154","volume":"116","author":"ChristopherD Gardner","year":"2022","unstructured":"Gardner, Christopher D., J. Matthew, Dalia Landry, Christina Perelman, Lindsay R. Petlura, Lucia Durand, Anthony Aronica, Crimarco, et al. 2022. Effect of a ketogenic diet versus mediterranean diet on glycated hemoglobin in individuals with prediabetes and type 2 diabetes mellitus: The interventional Keto-Med randomized crossover trial. American Journal of Clinical Nutrition 116: 640\u2013652. https:\/\/doi.org\/10.1093\/ajcn\/nqac154.","journal-title":"American Journal of Clinical Nutrition"},{"key":"2367_CR24","doi-asserted-by":"publisher","first-page":"917329","DOI":"10.3389\/fphar.2022.917329","volume":"13","author":"Pan Li","year":"2022","unstructured":"Li, Pan, Ruoyu Zhang, Meng Wang, Yuwei Chen, Zhiwei Chen, Xiumei Ke, Ling Zuo, and Jianwei Wang. 2022. Baicalein prevents fructose-induced hepatic steatosis in rats: In the regulation of fatty acid de novo synthesis, fatty acid elongation and fatty acid oxidation. Frontiers in Pharmacology 13: 917329. https:\/\/doi.org\/10.3389\/fphar.2022.917329.","journal-title":"Frontiers in Pharmacology"},{"key":"2367_CR25","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1007\/s12020-019-02124-3","volume":"67","author":"Mikiko Watanabe","year":"2020","unstructured":"Watanabe, Mikiko, Garima Singhal, Ffolliott M. Fisher, Thomas C. Beck, Donald A. Morgan, Fabio Socciarelli, and Marie L. Mather et al. 2020. Liver-derived FGF21 is essential for full adaptation to ketogenic diet but does not regulate glucose homeostasis. Endocrine 67:95\u2013108. https:\/\/doi.org\/10.1007\/s12020-019-02124-3","journal-title":"Endocrine"},{"key":"2367_CR26","doi-asserted-by":"publisher","first-page":"e13024","DOI":"10.1111\/obr.13024","volume":"21","author":"Mikiko Watanabe","year":"2020","unstructured":"Watanabe, Mikiko, Rossella Tozzi, Renata Risi, Dario Tuccinardi, Stefania Mariani, Sabrina Basciani, Giovanni Spera, Carla Lubrano, and Lucio Gnessi. 2020. Beneficial effects of the ketogenic diet on nonalcoholic fatty liver disease: A comprehensive review of the literature. Obesity Reviews 21:e13024. https:\/\/doi.org\/10.1111\/obr.13024","journal-title":"Obesity Reviews"},{"key":"2367_CR27","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1016\/j.nutres.2015.12.002","volume":"36","author":"Xiaoyu Zhang","year":"2016","unstructured":"Zhang, Xiaoyu, Juliang Qin, Yihan Zhao, Jueping Shi, Rong Lan, Yunqiu Gan, Hua Ren, Bing Zhu, Min Qian, and Bing Du. 2016. Long-term ketogenic diet contributes to glycemic control but promotes lipid accumulation and hepatic steatosis in type 2 diabetic mice. Nutrition Research 36:349\u2013358. https:\/\/doi.org\/10.1016\/j.nutres.2015.12.002","journal-title":"Nutrition Research"},{"key":"2367_CR28","doi-asserted-by":"publisher","unstructured":"Anekwe, Chika, Poongodi Chandrasekaran, and C Stanford Fatima. 2020. Ketogenic Diet-induced Elevated Cholesterol, Elevated Liver Enzymes and Potential Non-alcoholic Fatty Liver Disease. Cureus. https:\/\/doi.org\/10.7759\/cureus.6605","DOI":"10.7759\/cureus.6605"},{"key":"2367_CR29","doi-asserted-by":"publisher","first-page":"1370","DOI":"10.3390\/nu13041370","volume":"13","author":"Arianna Mazzoli","year":"2021","unstructured":"Mazzoli, Arianna, Cristina Gatto, Raffaella Crescenzo, and Luisa Cigliano. 2021. Prolonged changes in hepatic mitochondrial activity and insulin sensitivity by high fructose intake in adolescent rats. Nutrients 13: 1370. https:\/\/doi.org\/10.3390\/nu13041370.","journal-title":"Nutrients"},{"key":"2367_CR30","doi-asserted-by":"publisher","first-page":"C847","DOI":"10.1152\/ajpcell.00439.2021","volume":"323","author":"DanikoP Sindhunata","year":"2022","unstructured":"Sindhunata, Daniko P., A. Stijn, Victor EA. Meijnikman, and Gerdes. 2022. Dietary fructose as a metabolic risk factor. American Journal of Physiology-Cell Physiology 323: C847\u2013C856. https:\/\/doi.org\/10.1152\/ajpcell.00439.2021.","journal-title":"American Journal of Physiology-Cell Physiology"},{"key":"2367_CR31","doi-asserted-by":"publisher","first-page":"2846","DOI":"10.3390\/nu14142846","volume":"14","author":"Danielle Lee","year":"2022","unstructured":"Lee, Danielle, Laura Chiavaroli, Sabrina Ayoub-Charette, Tauseef A. Khan, Andreea Zurbau, Fei Au-Yeung, Annette Cheung, et al. 2022. Important food sources of fructose-containing sugars and non-alcoholic fatty liver disease: A systematic review and meta-analysis of controlled trials. Nutrients 14: 2846. https:\/\/doi.org\/10.3390\/nu14142846.","journal-title":"Nutrients"},{"key":"2367_CR32","doi-asserted-by":"publisher","first-page":"S244","DOI":"10.3350\/cmh.2022.0364","volume":"29","author":"Georg Semmler","year":"2023","unstructured":"Semmler, Georg, and Christian Datz, Michael Trauner. 2023. Eating, diet, and nutrition for the treatment of non-alcoholic fatty liver disease. Clinical and Molecular Hepatology 29:S244\u2013S260. https:\/\/doi.org\/10.3350\/cmh.2022.0364","journal-title":"Clinical and Molecular Hepatology"},{"key":"2367_CR33","doi-asserted-by":"publisher","first-page":"4208","DOI":"10.3390\/nu16234208","volume":"16","author":"Minghui Xiang","year":"2024","unstructured":"Xiang, Minghui, Xiaoli Tian, Hui Wang, and Qian Zhang. 2024. Inappropriate diet exacerbates metabolic dysfunction-associated steatotic liver disease via abdominal obesity. Nutrients 16: 4208. https:\/\/doi.org\/10.3390\/nu16234208.","journal-title":"Nutrients"},{"key":"2367_CR34","doi-asserted-by":"publisher","first-page":"156028","DOI":"10.1016\/j.metabol.2024.156028","volume":"161","author":"Xu-Fen Zeng","year":"2024","unstructured":"Zeng, Xu-Fen, Krista A. Varady, Xiang-Dong Wang, Giovanni Targher, Christopher D. Byrne, Reema Tayyem, and Giovanni Latella et al. 2024. The role of dietary modification in the prevention and management of metabolic dysfunction-associated fatty liver disease: An international multidisciplinary expert consensus. Metabolism 161:156028. https:\/\/doi.org\/10.1016\/j.metabol.2024.156028","journal-title":"Metabolism"},{"key":"2367_CR35","doi-asserted-by":"publisher","first-page":"110287","DOI":"10.1016\/j.foodres.2021.110287","volume":"143","author":"Fatma Akar","year":"2021","unstructured":"Akar, Fatma, Esra Sumlu, Mehmet Eray Al\u00e7\u0131\u011f\u0131r, Aykut Bostanc\u0131, and G\u00f6khan Sadi. 2021. Potential mechanistic pathways underlying intestinal and hepatic effects of Kefir in high-fructose-fed rats. Food Research International 143:110287. https:\/\/doi.org\/10.1016\/j.foodres.2021.110287","journal-title":"Food Research International"},{"key":"2367_CR36","doi-asserted-by":"publisher","first-page":"9894","DOI":"10.1038\/s41598-021-88872-7","volume":"11","author":"In-Jin Cho","year":"2021","unstructured":"Cho, In-Jin., Da-Hee. Oh, Jin Yoo, You-Cheol. Hwang, Kyu Jeung Ahn, Ho-Yeon. Chung, Soung Won Jeong, et al. 2021. Allopurinol ameliorates high fructose diet induced hepatic steatosis in diabetic rats through modulation of lipid metabolism, inflammation, and ER stress pathway. Scientific Reports 11: 9894. https:\/\/doi.org\/10.1038\/s41598-021-88872-7.","journal-title":"Scientific Reports"},{"key":"2367_CR37","doi-asserted-by":"publisher","first-page":"96","DOI":"10.3390\/nu9020096","volume":"9","author":"Qian Chen","year":"2017","unstructured":"Chen, Qian, Tingting Wang, Jian Li, Sijian Wang, Feng Qiu, Haiyang Yu, Yi. Zhang, and Tao Wang. 2017. Effects of natural products on fructose-induced nonalcoholic fatty liver disease (NAFLD). Nutrients 9: 96. https:\/\/doi.org\/10.3390\/nu9020096.","journal-title":"Nutrients"},{"key":"2367_CR38","doi-asserted-by":"publisher","first-page":"101196","DOI":"10.1016\/j.molmet.2021.101196","volume":"48","author":"JemyA Gutierrez","year":"2021","unstructured":"Gutierrez, Jemy A., Wei Liu, Sylvie Perez, Gang Xing, Gabriele Sonnenberg, Kou Kou, Matt Blatnik, et al. 2021. Pharmacologic inhibition of ketohexokinase prevents fructose-induced metabolic dysfunction. Molecular Metabolism 48: 101196. https:\/\/doi.org\/10.1016\/j.molmet.2021.101196.","journal-title":"Molecular Metabolism"},{"key":"2367_CR39","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/7172492","author":"Nildem Kizilaslan","year":"2022","unstructured":"Kizilaslan, Nildem, Nihal Zekiye Erdem, Muzaffer Katar, and Fikret Gevrek. 2022. The effects of probiotics and omega-3 fatty acids in liver steatosis induced in rats by high-fructose corn syrup. International Journal of Clinical Practice. https:\/\/doi.org\/10.1155\/2022\/7172492.","journal-title":"International Journal of Clinical Practice"},{"key":"2367_CR40","doi-asserted-by":"publisher","first-page":"1939","DOI":"10.1093\/jn\/123.11.1939","volume":"123","author":"Philip G Reeves","year":"1993","unstructured":"Reeves, Philip G, H. Forrest, Nielsen, and C Fahey George. 1993. AIN-93 purified diets for laboratory rodents: Final report of the American Institute of nutrition ad hoc writing committee on the reformulation of the AIN-76A rodent diet. The Journal of Nutrition 123:1939\u20131951. https:\/\/doi.org\/10.1093\/jn\/123.11.1939","journal-title":"The Journal of Nutrition"},{"key":"2367_CR41","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1016\/j.nut.2016.06.016","volume":"33","author":"Patricia Azevedo De Lima","year":"2017","unstructured":"Azevedo De Lima, Patricia, Mariana Baldini Prud\u00eancio, Daniela Kawamoto Murakami, Leticia Pereira De Brito Sampaio, Ant\u00f4nio Martins Figueiredo Neto, and N\u00e1gila Raquel. Teixeira Damasceno. 2017. Effect of classic ketogenic diet treatment on lipoprotein subfractions in children and adolescents with refractory epilepsy. Nutrition 33: 271\u2013277. https:\/\/doi.org\/10.1016\/j.nut.2016.06.016.","journal-title":"Nutrition"},{"key":"2367_CR42","doi-asserted-by":"publisher","first-page":"885","DOI":"10.1038\/labinvest.2011.44","volume":"91","author":"Giridhar Kanuri","year":"2011","unstructured":"Kanuri, Giridhar, Astrid Spruss, Sabine Wagnerberger, Stephan C Bischoff, and Ina Bergheim. 2011. Fructose-induced steatosis in mice: Role of plasminogen activator inhibitor-1, microsomal triglyceride transfer protein and NKT cells. Laboratory Investigation 91:885\u2013895. https:\/\/doi.org\/10.1038\/labinvest.2011.44","journal-title":"Laboratory Investigation"},{"key":"2367_CR43","doi-asserted-by":"publisher","first-page":"1094","DOI":"10.1002\/hep.23122","volume":"50","author":"Astrid Spruss","year":"2009","unstructured":"Spruss, Astrid, Giridhar Kanuri, Sabine Wagnerberger, Synia Haub, and Stephan C. Bischoff. 2009. Toll-like receptor 4 is involved in the development of fructose-induced hepatic steatosis in Mice\u2020. Hepatology 50: 1094\u20131104. https:\/\/doi.org\/10.1002\/hep.23122.","journal-title":"Hepatology"},{"key":"2367_CR44","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1016\/j.nutres.2018.11.003","volume":"62","author":"Nicole Fakhoury-Sayegh","year":"2019","unstructured":"Fakhoury-Sayegh, Nicole, Viviane Trak-Smayra, Raymond Sayegh, Faten Haidar, Omar Obeid, Sabine Asmar, and Aline Khazzaka. 2019. Fructose threshold for inducing organ damage in a rat model of nonalcoholic fatty liver disease. Nutrition Research 62:101\u2013112. https:\/\/doi.org\/10.1016\/j.nutres.2018.11.003","journal-title":"Nutrition Research"},{"key":"2367_CR45","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1016\/0003-2697(79)90738-3","volume":"95","author":"Hiroshi Ohkawa","year":"1979","unstructured":"Ohkawa, Hiroshi, Nobuko Ohishi, and Kunio Yagi. 1979. Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Analytical Biochemistry 95:351\u2013358. https:\/\/doi.org\/10.1016\/0003-2697(79)90738-3","journal-title":"Analytical Biochemistry"},{"key":"2367_CR46","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0115922","volume":"9","author":"Wen Liang","year":"2014","unstructured":"Liang, Wen, Aswin L.. Menke, Ann Driessen, Ger H.. Koek, Jan H.. Lindeman, Reinout Stoop, Louis M.. Havekes, Robert Kleemann, and Anita M.. Van Den Hoek. 2014. Establishment of a general NAFLD scoring system for rodent models and comparison to human liver pathology. PLoS ONE 9: e115922. https:\/\/doi.org\/10.1371\/journal.pone.0115922.","journal-title":"PLoS ONE"},{"key":"2367_CR47","doi-asserted-by":"publisher","unstructured":"Carrascosa, Jos\u00e9 M., Antonio Manuel Ros, and Andr\u00e9s. 2009. Teresa Fern\u00e1ndez-Agull\u00f3, and Carmen Arribas. Changes in the neuroendocrine control of energy homeostasis by adiposity signals during aging. Experimental Gerontology 44: 20\u201325. https:\/\/doi.org\/10.1016\/j.exger.2008.05.005","DOI":"10.1016\/j.exger.2008.05.005"},{"key":"2367_CR48","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1016\/B978-0-12-802388-4.00009-4","volume-title":"Sex Differences in Physiology","author":"Kelly Ethun","year":"2016","unstructured":"Ethun, Kelly. 2016. Sex and Gender Differences in Body Composition, Lipid Metabolism, and Glucose Regulation. In Sex Differences in Physiology, 145\u2013165. Elsevier. https:\/\/doi.org\/10.1016\/B978-0-12-802388-4.00009-4."},{"key":"2367_CR49","doi-asserted-by":"publisher","unstructured":"Quir\u00f3s Cognuck, Susana, Wagner L., Marcia Reis, Lucas K. Silva, Andre S. Debarba, J. A. Mecawi, Francisco, Celso Rodrigues De Paula, L. K. Franci, Lucila, Elias, and Jose Antunes-Rodrigues. 2020. Sex differences in body composition, metabolism\u2010related hormones, and energy homeostasis during aging in Wistar rats. Physiological Reports 8. https:\/\/doi.org\/10.14814\/phy2.14597","DOI":"10.14814\/phy2.14597"},{"key":"2367_CR50","doi-asserted-by":"publisher","unstructured":"Oosterman, Johanneke E., Laura L. Koekkoek, Ewout Foppen, Unga A. Unmehopa, Leslie Eggels, Joanne Verheij, Eric Fliers, Susanne E La Fleur, and and Andries Kalsbeek. 2020. Synergistic Effect of Feeding TimeDiet on Hepatic SteatosisGene Expression in Male Wistar Rats. Obesity 28. https:\/\/doi.org\/10.1002\/oby.22832","DOI":"10.1002\/oby.22832"},{"key":"2367_CR51","doi-asserted-by":"publisher","DOI":"10.1186\/1758-5996-6-130","volume":"6","author":"Nathalie Auberval","year":"2014","unstructured":"Auberval, Nathalie, St\u00e9phanie. Dal, William Bietiger, Michel Pinget, Nathalie Jeandidier, Elisa Maillard-Pedracini, Val\u00e9rie Schini-Kerth, and S\u00e9verine. Sigrist. 2014. Metabolic and oxidative stress markers in Wistar rats after 2 months on a high-fat diet. Diabetology & Metabolic Syndrome 6: 130. https:\/\/doi.org\/10.1186\/1758-5996-6-130.","journal-title":"Diabetology & Metabolic Syndrome"},{"key":"2367_CR52","doi-asserted-by":"publisher","first-page":"880298","DOI":"10.3389\/fimmu.2022.880298","volume":"13","author":"Yamei Duan","year":"2022","unstructured":"Duan, Yamei, Xiongfeng Pan, Jiayou Luo, Xiang Xiao, Jingya Li, Prince L. Bestman, and Miyang Luo. 2022. Association of inflammatory cytokines with non-alcoholic fatty liver disease. Frontiers in Immunology 13: 880298. https:\/\/doi.org\/10.3389\/fimmu.2022.880298.","journal-title":"Frontiers in Immunology"},{"key":"2367_CR53","doi-asserted-by":"publisher","first-page":"812431","DOI":"10.3389\/fimmu.2022.812431","volume":"13","author":"Shaoping She","year":"2022","unstructured":"She, Shaoping, Liying Ren, Pu Chen, Mingyang Wang, Dongbo Chen, Ying Wang, and Hongsong Chen. 2022. Functional roles of chemokine receptor CCR2 and its ligands in liver disease. Frontiers in Immunology 13:812431. https:\/\/doi.org\/10.3389\/fimmu.2022.812431","journal-title":"Frontiers in Immunology"},{"key":"2367_CR54","doi-asserted-by":"publisher","first-page":"1166","DOI":"10.3748\/wjg.v19.i8.1166","volume":"19","author":"Metin Basaranoglu","year":"2013","unstructured":"Basaranoglu, Metin. 2013. Fructose as a key player in the development of fatty liver disease. World Journal of Gastroenterology 19:1166. https:\/\/doi.org\/10.3748\/wjg.v19.i8.1166","journal-title":"World Journal of Gastroenterology"},{"key":"2367_CR55","doi-asserted-by":"publisher","first-page":"1864","DOI":"10.3390\/md13041864","volume":"13","author":"Rafael De Salim","year":"2015","unstructured":"De Salim, Rafael, Livia Cordeiro Deminice, Philip C. Sim\u00f5es-Ambrosio, Alceu A. Calder, and Jord\u00e3o, Helio Vannucchi. 2015. Dietary docosahexaenoic acid and eicosapentaenoic acid influence liver triacylglycerol and insulin resistance in rats fed a High-Fructose diet. Marine Drugs 13:1864\u20131881. https:\/\/doi.org\/10.3390\/md13041864","journal-title":"Marine Drugs"},{"key":"2367_CR56","doi-asserted-by":"publisher","first-page":"21240","DOI":"10.3390\/ijms141121240","volume":"14","author":"Akinobu Nakamura","year":"2013","unstructured":"Nakamura, Akinobu, and Yasuo Terauchi. 2013. Lessons from mouse models of High-Fat Diet-Induced NAFLD. International Journal of Molecular Sciences 14:21240\u201321257. https:\/\/doi.org\/10.3390\/ijms141121240","journal-title":"International Journal of Molecular Sciences"},{"key":"2367_CR57","doi-asserted-by":"publisher","first-page":"2079","DOI":"10.1007\/s00018-019-03390-0","volume":"77","author":"Johanna K DiStefano","year":"2020","unstructured":"DiStefano, Johanna K. 2020. Fructose-mediated effects on gene expression and epigenetic mechanisms associated with NAFLD pathogenesis. Cellular and Molecular Life Sciences 77:2079\u20132090. https:\/\/doi.org\/10.1007\/s00018-019-03390-0","journal-title":"Cellular and Molecular Life Sciences"},{"key":"2367_CR58","doi-asserted-by":"publisher","first-page":"2300","DOI":"10.3748\/wjg.v18.i19.2300","volume":"18","author":"Yoshihisa Takahashi","year":"2012","unstructured":"Takahashi, Yoshihisa. 2012. Animal models of nonalcoholic fatty liver disease\/nonalcoholic steatohepatitis. World Journal of Gastroenterology 18:2300. https:\/\/doi.org\/10.3748\/wjg.v18.i19.2300","journal-title":"World Journal of Gastroenterology"},{"key":"2367_CR59","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2019.00770","volume":"10","author":"HannahK. Drescher","year":"2019","unstructured":"Drescher, Hannah K.., Ralf Weiskirchen, Annabelle F\u00fcl\u00f6p, Carsten Hopf, Estibaliz Gonz\u00e1lez De San Rom\u00e1n, Pitter F.. Huesgen, Alain De Bruin, et al. 2019. The influence of different fat sources on steatohepatitis and fibrosis development in the Western diet mouse model of non-alcoholic steatohepatitis (NASH). Frontiers in Physiology 10: 770. https:\/\/doi.org\/10.3389\/fphys.2019.00770.","journal-title":"Frontiers in Physiology"},{"key":"2367_CR60","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2021.111908","volume":"141","author":"Pintu Miah","year":"2021","unstructured":"Miah, Pintu, Surovi Binte Sharmin. Mohona, Md. Mizanur. Rahman, Nusrat Subhan, Ferdous Khan, Hemayet Hossain, Shazid Md. Sharker, and Md. Ashraful. Alam. 2021. Supplementation of cumin seed powder prevents oxidative stress, hyperlipidemia and non-alcoholic fatty liver in high fat diet fed rats. Biomedicine & Pharmacotherapy 141: 111908. https:\/\/doi.org\/10.1016\/j.biopha.2021.111908.","journal-title":"Biomedicine & Pharmacotherapy"},{"key":"2367_CR61","doi-asserted-by":"publisher","first-page":"100877","DOI":"10.1016\/j.jhepr.2023.100877","volume":"5","author":"Mandy M Chan","year":"2023","unstructured":"Chan, Mandy M., Sabine Daemen, Joseph W. Beals, Marina Terekhova, Bin Q. Yang, Christina F. Fu, and Li He et al. 2023. Steatosis drives monocyte-derived macrophage accumulation in human metabolic dysfunction-associated fatty liver disease. JHEP Reports 5:100877. https:\/\/doi.org\/10.1016\/j.jhepr.2023.100877","journal-title":"JHEP Reports"},{"key":"2367_CR62","doi-asserted-by":"publisher","first-page":"2197","DOI":"10.1002\/hep.30097","volume":"68","author":"Leigh Goedeke","year":"2018","unstructured":"Goedeke, Leigh, Jamie Bates, Daniel F.. Vatner, Rachel J.. Perry, Ting Wang, Ricardo Ramirez, Li. Li, et al. 2018. Acetyl-CoA Carboxylase Inhibition Reverses NAFLD and Hepatic Insulin Resistance but Promotes Hypertriglyceridemia in Rodents. Hepatology 68: 2197\u20132211. https:\/\/doi.org\/10.1002\/hep.30097.","journal-title":"Hepatology"},{"key":"2367_CR63","doi-asserted-by":"publisher","first-page":"640557","DOI":"10.3389\/fnut.2021.640557","volume":"8","author":"Theresa Hydes","year":"2021","unstructured":"Hydes, Theresa, Uazman Alam, and Daniel J. Cuthbertson. 2021. The impact of macronutrient intake on Non-alcoholic fatty liver disease (NAFLD): Too much fat, too much carbohydrate, or just too many calories? Frontiers in Nutrition 8: 640557. https:\/\/doi.org\/10.3389\/fnut.2021.640557.","journal-title":"Frontiers in Nutrition"},{"key":"2367_CR64","doi-asserted-by":"publisher","unstructured":"Zaki, Sherif, Shereen Abdel Mohamed, Fattah, and Dina Salah Hassan. 2015. The differential effects of high-fat and high fructose diets on the liver of male albino rat and the proposed underlying mechanisms. Folia Morphologica: VM\/OJS\/J\/58582. https:\/\/doi.org\/10.5603\/FM.a2018.0063","DOI":"10.5603\/FM.a2018.0063"},{"key":"2367_CR65","doi-asserted-by":"publisher","DOI":"10.3390\/nu11091987","volume":"11","author":"Marja-Riitta Taskinen","year":"2019","unstructured":"Taskinen, Marja-Riitta., Chris J. Packard, and Jan Bor\u00e9n. 2019. Dietary fructose and the metabolic syndrome. Nutrients 11: 1987. https:\/\/doi.org\/10.3390\/nu11091987.","journal-title":"Nutrients"},{"key":"2367_CR66","doi-asserted-by":"publisher","first-page":"2868","DOI":"10.1007\/s11064-020-03135-7","volume":"45","author":"Barbara Dos Santos","year":"2020","unstructured":"Dos Santos, Barbara, Ariana Ern Schmitz, Gudrian Ricardo Lopes. De Almeida, Luiz Felipe De Souza, Jozimar Carlos Szczepanik, Everson Ara\u00fajo Nunes, Henver Simionato Brunetta, et al. 2020. Fructose intake impairs cortical antioxidant defenses allied to hyperlocomotion in middle-aged C57BL\/6 female mice. Neurochemical Research 45: 2868\u20132883. https:\/\/doi.org\/10.1007\/s11064-020-03135-7.","journal-title":"Neurochemical Research"},{"key":"2367_CR67","doi-asserted-by":"publisher","first-page":"99","DOI":"10.5650\/jos.ess22266","volume":"72","author":"Masaya Shimada","year":"2023","unstructured":"Shimada, Masaya, Bungo Shirouchi, Yota Kobayashi, Mina Higuchi, Mai Okumura, Tomoyuki Nakagawa, and Takashi Hayakawa. 2023. Treatment with Interleukin-25 suppresses Short-Term High-Fructose Diet-Induced hepatic gene expression and activities of fatty acid synthesis enzymes in rats. Journal of Oleo Science 72:99\u2013104. https:\/\/doi.org\/10.5650\/jos.ess22266","journal-title":"Journal of Oleo Science"},{"key":"2367_CR68","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1055\/s-0042-118386","volume":"67","author":"Mehmet Pektas","year":"2016","unstructured":"Pektas, Mehmet, G\u00f6zde Y\u00fccel, Halit Koca, G\u00f6khan Sadi, and Onur Y\u0131ld\u0131r\u0131m, G\u00f6zde \u00d6zt\u00fcrk, Fatma Akar. 2016. Dietary Fructose-Induced hepatic injury in male and female rats: Influence of Resveratrol. Drug Research 67:103\u2013110. https:\/\/doi.org\/10.1055\/s-0042-118386","journal-title":"Drug Research"},{"key":"2367_CR69","doi-asserted-by":"publisher","first-page":"290","DOI":"10.1017\/S0029665119000570","volume":"78","author":"J. Bernadette Moore","year":"2019","unstructured":"Moore, J. Bernadette. 2019. From sugar to liver fat and public health: Systems biology driven studies in understanding non-alcoholic fatty liver disease pathogenesis. Proceedings of the Nutrition Society 78: 290\u2013304. https:\/\/doi.org\/10.1017\/S0029665119000570.","journal-title":"Proceedings of the Nutrition Society"},{"key":"2367_CR70","doi-asserted-by":"publisher","first-page":"S24","DOI":"10.1016\/j.arteri.2021.10.001","volume":"34","author":"Niki Katsiki","year":"2022","unstructured":"Katsiki, Niki, Anca Pantea Stoian, and Manfredi Rizzo. 2022. Dietary patterns in non-alcoholic fatty liver disease (NAFLD): Stay on the straight and narrow path! Cl\u00ednica e Investigaci\u00f3n en Arteriosclerosis 34: S24\u2013S31. https:\/\/doi.org\/10.1016\/j.arteri.2021.10.001.","journal-title":"Cl\u00ednica e Investigaci\u00f3n en Arteriosclerosis"},{"key":"2367_CR71","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/306326","volume":"2015","author":"JaiSun Lee","year":"2015","unstructured":"Lee, Jai Sun, Dae Won Jun, Eun Kyung Kim, Hye Joon Jeon, Ho Hyun Nam, and Waqar Khalid Saeed. 2015. Histologic and metabolic derangement in high-fat, high\u2010fructose, and combination diet animal models. The Scientific World Journal 2015: 306326. https:\/\/doi.org\/10.1155\/2015\/306326.","journal-title":"The Scientific World Journal"},{"key":"2367_CR72","doi-asserted-by":"publisher","first-page":"586","DOI":"10.1038\/s41586-020-2101-7","volume":"579","author":"Steven Zhao","year":"2020","unstructured":"Zhao, Steven, Cholsoon Jang, Joyce Liu, Kahealani Uehara, Michael Gilbert, Luke Izzo, and Xianfeng Zeng et al. 2020. Dietary Fructose feeds hepatic lipogenesis via microbiota-derived acetate. Nature 579:586\u2013591. https:\/\/doi.org\/10.1038\/s41586-020-2101-7","journal-title":"Nature"},{"issue":"1","key":"2367_CR73","doi-asserted-by":"publisher","DOI":"10.1002\/jgh3.70099","volume":"9","author":"S Chirapongsathorn","year":"2025","unstructured":"Chirapongsathorn, S., W. Rintaravitoon, B. Tangjaturonrasme, et al. 2025. Effect of a Ketogenic Diet on Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) Progression: A Randomized Controlled Trial. JGH Open\u202f: An Official Journal of the Japan Gastroenterological Endoscopy Society 9 (1): e70099. https:\/\/doi.org\/10.1002\/jgh3.70099.","journal-title":"JGH Open : An Official Journal of the Japan Gastroenterological Endoscopy Society"},{"key":"2367_CR74","doi-asserted-by":"publisher","first-page":"1127","DOI":"10.1016\/j.metabol.2005.03.018","volume":"54","author":"Ameer `Y Taha","year":"2005","unstructured":"Taha, Ameer `Y., Mary Ann, A. Ryan, and Stephen C. Cunnane. 2005. Despite transient ketosis, the classic high-fat ketogenic diet induces marked changes in fatty acid metabolism in rats. Metabolism 54:1127\u20131132. https:\/\/doi.org\/10.1016\/j.metabol.2005.03.018","journal-title":"Metabolism"},{"key":"2367_CR75","doi-asserted-by":"publisher","first-page":"1400","DOI":"10.1111\/j.1528-1157.2000.tb00115.x","volume":"41","author":"SS Likhodii","year":"2000","unstructured":"Likhodii, S. S., K. Musa, A. Mendonca, C. Dell, W. M. Burnham, and S. C. Cunnane. 2000. Dietary fat, ketosis, and seizure resistance in rats on the ketogenic diet. Epilepsia 41:1400\u20131410. https:\/\/doi.org\/10.1111\/j.1528-1157.2000.tb00115.x","journal-title":"Epilepsia"},{"key":"2367_CR76","first-page":"HY19","volume":"8","author":"SergeiS. Likhodii","year":"2002","unstructured":"Likhodii, Sergei S.., and W. McIntyre. Burnham. 2002. Ketogenic diet: Does acetone stop seizures? Medical Science Monitor\u202f: International Medical Journal of Experimental and Clinical Research 8: HY19-24.","journal-title":"Medical Science Monitor : International Medical Journal of Experimental and Clinical Research"},{"key":"2367_CR77","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1590\/1678-98652017000100010","volume":"30","author":"MarianaBaldini Prudencio","year":"2017","unstructured":"Prudencio, Mariana Baldini, Patricia De Azevedo Lima, Maria Camila Pruper De Freitas, Fl\u00e1via. De Conti Cartolano, Daniela Kawamoto Murakami, and N\u00e1gila Raquel. Teixeira Damasceno. 2017. Ketogenic food pyramid for patients with refractory epilepsy: From theory to clinical practice. Revista de Nutri\u00e7\u00e3o 30: 99\u2013108. https:\/\/doi.org\/10.1590\/1678-98652017000100010.","journal-title":"Revista de Nutri\u00e7\u00e3o"},{"key":"2367_CR78","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1179\/1476830515Y.0000000036","volume":"18","author":"PatriciaAzevedo Lima","year":"2015","unstructured":"Lima, Patricia Azevedo, Leticia Pereira De Brito Sampaio, and N\u00e1gila Raquel. Teixeira Damasceno. 2015. Ketogenic diet in epileptic children: Impact on lipoproteins and oxidative stress. Nutritional Neuroscience 18: 337\u2013344. https:\/\/doi.org\/10.1179\/1476830515Y.0000000036.","journal-title":"Nutritional Neuroscience"},{"key":"2367_CR79","doi-asserted-by":"publisher","first-page":"4447","DOI":"10.1172\/JCI82204","volume":"125","author":"Santhosh Satapati","year":"2015","unstructured":"Satapati, Santhosh, Blanka Kucejova, Joao A. G.. Duarte, Justin A.. Fletcher, Lacy Reynolds, Nishanth E.. Sunny, Tianteng He, et al. 2015. Mitochondrial metabolism mediates oxidative stress and inflammation in fatty liver. Journal of Clinical Investigation 125: 4447\u20134462. https:\/\/doi.org\/10.1172\/JCI82204.","journal-title":"Journal of Clinical Investigation"},{"key":"2367_CR80","doi-asserted-by":"publisher","first-page":"101494","DOI":"10.1016\/j.molmet.2022.101494","volume":"61","author":"Shaza Asif","year":"2022","unstructured":"Asif, Shaza, Ri Youn Kim, Thet Fatica, Jordan Sim, Xiaoling Zhao, Yena Oh, and Alix Denoncourt et al. 2022. Hmgcs2-mediated ketogenesis modulates high-fat diet-induced hepatosteatosis. Molecular Metabolism 61:101494. https:\/\/doi.org\/10.1016\/j.molmet.2022.101494","journal-title":"Molecular Metabolism"},{"key":"2367_CR81","doi-asserted-by":"publisher","first-page":"113687","DOI":"10.1016\/j.bbr.2021.113687","volume":"419","author":"Alex M Maya-Romero","year":"2022","unstructured":"Maya-Romero, Alex M., E. Gina, Justine D. Dodd, Helen K. Landin, F. Zaremba, Omar, Mackenzie A. Allen, Rhyce D. Bilbow, Hammaker, and Jessica L. Santerre-Anderson. 2022. Adolescent high-fructose corn syrup consumption leads to dysfunction in adult affective behaviors and mesolimbic proteins in male Sprague-Dawley rats. Behavioural Brain Research 419:113687. https:\/\/doi.org\/10.1016\/j.bbr.2021.113687","journal-title":"Behavioural Brain Research"},{"key":"2367_CR82","doi-asserted-by":"publisher","first-page":"1901141","DOI":"10.1002\/mnfr.201901141","volume":"64","author":"Danijela Milutinovi\u0107","year":"2020","unstructured":"Milutinovi\u0107, Danijela, Jelena Vojnovi\u0107, Ana Brklja\u010di\u0107, Biljana Teofilovi\u0107, Marina Bursa\u0107, Ljupka Nikoli\u0107, Sanja Gligorovska, et al. 2020. Chronic stress potentiates high fructose\u2013induced lipogenesis in rat liver and kidney. Molecular Nutrition & Food Research 64: 1901141. https:\/\/doi.org\/10.1002\/mnfr.201901141.","journal-title":"Molecular Nutrition & Food Research"},{"key":"2367_CR83","doi-asserted-by":"publisher","first-page":"113260","DOI":"10.1016\/j.physbeh.2020.113260","volume":"229","author":"Tyler S Garman","year":"2021","unstructured":"Garman, Tyler S., Barry Setlow, and Caitlin A. Orsini. 2021. Effects of a high-fat diet on impulsive choice in rats. Physiology & Behavior 229:113260. https:\/\/doi.org\/10.1016\/j.physbeh.2020.113260","journal-title":"Physiology & Behavior"},{"key":"2367_CR84","doi-asserted-by":"publisher","DOI":"10.1515\/biol-2022-0529","volume":"18","author":"Cuauht\u00e9moc Sandoval-Salazar","year":"2023","unstructured":"Sandoval-Salazar, Cuauht\u00e9moc, Sandra Neli Jim\u00e9nez-Garc\u00eda, Vicente Beltr\u00e1n-Campos, Luz Elvia Vera-Becerra, and Carlos Alberto N\u00fa\u00f1ez-Col\u00edn. 2023. Effect of berrycactus fruit (Myrtillocactus geometrizans) on glutamate, glutamine, and GABA levels in the frontal cortex of rats fed with a high-fat diet. Open Life Sciences 18: 20220529. https:\/\/doi.org\/10.1515\/biol-2022-0529.","journal-title":"Open Life Sciences"},{"key":"2367_CR85","doi-asserted-by":"publisher","first-page":"677","DOI":"10.1089\/jmf.2011.0075","volume":"14","author":"Joaqu\u00edn P\u00e9rez-Guisado","year":"2011","unstructured":"P\u00e9rez-Guisado, Joaqu\u00edn, and Andr\u00e9s Mu\u00f1oz-Serrano. 2011. The effect of the Spanish ketogenic mediterranean diet on nonalcoholic fatty liver disease: A pilot study. Journal of Medicinal Food 14:677\u2013680. https:\/\/doi.org\/10.1089\/jmf.2011.0075","journal-title":"Journal of Medicinal Food"},{"issue":"1","key":"2367_CR86","doi-asserted-by":"publisher","DOI":"10.1038\/s41387-025-00391-w","volume":"15","author":"Y You","year":"2025","unstructured":"You, Y., H. Ni, and Q. Ma. 2025. Ketogenic diet ameliorates MASLD via balancing mitochondrial dynamics and improving mitochondrial dysfunction. Nutrition & Diabetes 15 (1): 37. https:\/\/doi.org\/10.1038\/s41387-025-00391-w.","journal-title":"Nutrition & Diabetes"},{"key":"2367_CR87","doi-asserted-by":"publisher","first-page":"S5","DOI":"10.1017\/S0007114511005460","volume":"106","author":"Philip C Calder","year":"2011","unstructured":"Calder, Philip C., Namanjeet Ahluwalia, Fred Brouns, Timo Buetler, Karine Clement, Karen Cunningham, and Katherine Esposito et al. 2011. Dietary factors and low-grade inflammation in relation to overweight and obesity. British Journal of Nutrition 106:S5\u2013S78. https:\/\/doi.org\/10.1017\/S0007114511005460","journal-title":"British Journal of Nutrition"},{"key":"2367_CR88","doi-asserted-by":"publisher","DOI":"10.3390\/nu8110682","volume":"8","author":"Lorena Da Silva-Santi","year":"2016","unstructured":"Da Silva-Santi, Lorena, Marina Antunes, Silvana Caparroz-Assef, Fabiana Carbonera, Laureane Masi, Rui Curi, Jesu\u00ed Visentainer, and Roberto Bazotte. 2016. Liver fatty acid composition and inflammation in mice fed with high-carbohydrate diet or high-fat diet. Nutrients 8: 682. https:\/\/doi.org\/10.3390\/nu8110682.","journal-title":"Nutrients"},{"key":"2367_CR89","doi-asserted-by":"publisher","first-page":"330","DOI":"10.3390\/ijms22010330","volume":"22","author":"Gaetan Ravaut","year":"2020","unstructured":"Ravaut, Gaetan, Alexandre L\u00e9giot, and Karl-F. Bergeron. 2020. Monounsaturated fatty acids in obesity-related inflammation. International Journal of Molecular Sciences 22: 330. https:\/\/doi.org\/10.3390\/ijms22010330.","journal-title":"International Journal of Molecular Sciences"},{"key":"2367_CR90","doi-asserted-by":"publisher","first-page":"116074","DOI":"10.1016\/j.taap.2022.116074","volume":"448","author":"Zeyu Li","year":"2022","unstructured":"Li, Zeyu, Kanglin Wu, Yi Zou, Wei Gong, Peng Wang, and Hong Wang. 2022. PREX1 depletion ameliorates high-fat diet-induced non-alcoholic fatty liver disease in mice and mitigates palmitic acid-induced hepatocellular injury via suppressing the NF-\u03baB signaling pathway. Toxicology and Applied Pharmacology 448:116074. https:\/\/doi.org\/10.1016\/j.taap.2022.116074","journal-title":"Toxicology and Applied Pharmacology"},{"key":"2367_CR91","doi-asserted-by":"publisher","first-page":"933","DOI":"10.1007\/s11745-006-5046-1","volume":"41","author":"AmeerY. Taha","year":"2006","unstructured":"Taha, Ameer Y.., Mary Ann Ryan, and Stephen C.. Cunnane. 2006. Markedly raised intake of saturated and monounsaturated fatty acids in rats on a high-fat ketogenic diet does not inhibit carbon recycling of<Superscript>13<\/Superscript> C\u2010\u03b1\u2010linolenate. Lipids 41: 933\u2013935. https:\/\/doi.org\/10.1007\/s11745-006-5046-1.","journal-title":"Lipids"},{"key":"2367_CR92","doi-asserted-by":"publisher","first-page":"2124","DOI":"10.1194\/jlr.M700600-JLR200","volume":"49","author":"Jennifer K Yee","year":"2008","unstructured":"Yee, Jennifer K., S. Catherine, Heidi S. Mao, Shu Hummel, Sharon Lim, Virender K. Sugano, and Gary Xiao Rehan, Wai-Nang Paul Lee. 2008. Compartmentalization of stearoyl-coenzyme A desaturase 1 activity in HepG2 cells. Journal of Lipid Research 49:2124\u20132134. https:\/\/doi.org\/10.1194\/jlr.M700600-JLR200","journal-title":"Journal of Lipid Research"},{"key":"2367_CR93","doi-asserted-by":"publisher","first-page":"539","DOI":"10.1016\/j.cmet.2017.08.005","volume":"26","author":"Megan N Roberts","year":"2017","unstructured":"Roberts, Megan N., A. Marita, Alexey A. Wallace, Zeyu Tomilov, George R. Zhou, Dianna Marcotte, Gabriella Tran, and Perez et al. 2017. A ketogenic diet extends longevity and healthspan in adult mice. Cell Metabolism 26:539\u2013546e5. https:\/\/doi.org\/10.1016\/j.cmet.2017.08.005","journal-title":"Cell Metabolism"}],"container-title":["Inflammation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10753-025-02367-5","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10753-025-02367-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10753-025-02367-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,5]],"date-time":"2026-04-05T10:01:52Z","timestamp":1775383312000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10753-025-02367-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,23]]},"references-count":93,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["2367"],"URL":"https:\/\/doi.org\/10.1007\/s10753-025-02367-5","relation":{},"ISSN":["1573-2576"],"issn-type":[{"value":"1573-2576","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,23]]},"assertion":[{"value":"22 May 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 November 2025","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 November 2025","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 March 2026","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Approval for this study was obtained by the Animal Research Ethics Committee (CEUA-FMUSP n\u00ba 1696\/2021).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical Approval"}},{"value":"This study constitutes fundamental scientific research and does not involve human clinical trials; therefore, no Clinical Trial Number (e.g., NCT identifier) is applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Clinical Trial Number"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"129"}}