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This study did not involve human subjects. All animal procedures were approved by the Animal Ethics Committee of Tianjin Medical University General Hospital (Approval No. IRB2024-DW-71) and strictly adhered to: ARRIVE guidelines (Animal Research: Reporting of In Vivo Experiments), Institutional animal welfare standards.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics Approval"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent To Publish"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing Interests"}}],"article-number":"34"}}