{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T13:21:41Z","timestamp":1782912101705,"version":"3.54.5"},"reference-count":51,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T00:00:00Z","timestamp":1770163200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T00:00:00Z","timestamp":1771459200000},"content-version":"vor","delay-in-days":15,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82170853"],"award-info":[{"award-number":["82170853"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82100084"],"award-info":[{"award-number":["82100084"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004607","name":"Natural Science Foundation of Guangxi Province","doi-asserted-by":"publisher","award":["2024GXNSFAA999056"],"award-info":[{"award-number":["2024GXNSFAA999056"]}],"id":[{"id":"10.13039\/501100004607","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004735","name":"Hunan Provincial Natural Science Foundation of China","doi-asserted-by":"crossref","award":["2025JJ50523"],"award-info":[{"award-number":["2025JJ50523"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Inflammation"],"DOI":"10.1007\/s10753-025-02439-6","type":"journal-article","created":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T07:05:59Z","timestamp":1770188759000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Impaired BCAA Catabolism Contributes To Acute Lung Injury By Triggering Oxidative Stress and Inflammatory Response Via the MAPK Pathway"],"prefix":"10.1007","volume":"49","author":[{"given":"Da-Yan","family":"Xiong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen-Yu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin-Tong","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Si-Yuan","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Ting","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,2,4]]},"reference":[{"issue":"1","key":"2439_CR1","doi-asserted-by":"publisher","first-page":"926","DOI":"10.1186\/s12967-025-06994-2","volume":"23","author":"H Liu","year":"2025","unstructured":"Liu, H., J. Dong, C. Xu, Y. Ni, Z. Ye, Z. Sun, H. Fan, and Y. Chen. 2025. Acute lung injury: Pathogenesis and treatment. Journal of Translational Medicine 23 (1): 926. https:\/\/doi.org\/10.1186\/s12967-025-06994-2.","journal-title":"Journal of Translational Medicine"},{"issue":"41","key":"2439_CR2","doi-asserted-by":"publisher","first-page":"e06287","DOI":"10.1002\/advs.202506287","volume":"12","author":"S Li","year":"2025","unstructured":"Li, S., W. Zhuang, Y. Wang, H. Qin, X. Qin, X. Yan, X. Hu, X. Liu, and C. Chen. 2025. CXCR1 depletion in Ly6C(+) cDC2 alleviates acute lung injury via modulation of Th17\/Treg balance. Advanced Science: e06287. https:\/\/doi.org\/10.1002\/advs.202506287.","journal-title":"Advanced Science"},{"issue":"1","key":"2439_CR3","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1186\/s12967-023-04027-4","volume":"21","author":"WJ Zhong","year":"2023","unstructured":"Zhong, W. J., J. Zhang, J. X. Duan, C. Y. Zhang, S. C. Ma, Y. S. Li, N. S. Yang, H. H. Yang, J. B. Xiong, C. X. Guan, Z. X. Jiang, Z. J. You, and Y. Zhou. 2023. TREM-1 triggers necroptosis of macrophages through mTOR-dependent mitochondrial fission during acute lung injury. J Transl Med 21(1):179. https:\/\/doi.org\/10.1186\/s12967-023-04027-4","journal-title":"J Transl Med"},{"issue":"1","key":"2439_CR4","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1186\/s12967-023-04828-7","volume":"22","author":"J Zhang","year":"2024","unstructured":"Zhang, J., Y. Guo, M. Mak, and Z. Tao. 2024. Translational medicine for acute lung injury. Journal of Translational Medicine 22 (1): 25. https:\/\/doi.org\/10.1186\/s12967-023-04828-7.","journal-title":"Journal of Translational Medicine"},{"issue":"12","key":"2439_CR5","doi-asserted-by":"publisher","first-page":"4713","DOI":"10.7150\/ijbs.99456","volume":"20","author":"HX Sha","year":"2024","unstructured":"Sha, H. X., Y. B. Liu, Y. L. Qiu, W. J. Zhong, N. S. Yang, C. Y. Zhang, J. X. Duan, J. B. Xiong, C. X. Guan, and Y. Zhou. 2024. Neutrophil extracellular traps trigger alveolar epithelial cell necroptosis through the cGAS-STING pathway during acute lung injury in mice. International Journal of Biological Sciences 20(12):4713\u20134730. https:\/\/doi.org\/10.7150\/ijbs.99456","journal-title":"International Journal of Biological Sciences"},{"issue":"4","key":"2439_CR6","doi-asserted-by":"publisher","first-page":"589","DOI":"10.1038\/s42255-023-00794-y","volume":"5","author":"MC Blair","year":"2023","unstructured":"Blair, M.C., M.D. Neinast, C. Jang, Q. Chu, J.W. Jung, J. Axsom, M.R. Bornstein, C. Thorsheim, K. Li, A. Hoshino, S. Yang, R.J. Roth Flach, B.B. Zhang, J.D. Rabinowitz, and Z. Arany. 2023. Branched-chain amino acid catabolism in muscle affects systemic BCAA levels but not insulin resistance. Nature Metabolism 5 (4): 589\u2013606. https:\/\/doi.org\/10.1038\/s42255-023-00794-y.","journal-title":"Nature Metabolism"},{"issue":"2","key":"2439_CR7","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1038\/s41569-022-00760-3","volume":"20","author":"RW McGarrah","year":"2023","unstructured":"McGarrah, R. W., and P. J. White. 2023. Branched-chain amino acids in cardiovascular disease. Nature Reviews. Cardiology 20(2):77\u201389. https:\/\/doi.org\/10.1038\/s41569-022-00760-3","journal-title":"Nature Reviews. Cardiology"},{"issue":"3","key":"2439_CR8","doi-asserted-by":"publisher","first-page":"112186","DOI":"10.1016\/j.celrep.2023.112186","volume":"42","author":"CC Yao","year":"2023","unstructured":"Yao, C. C., R. M. Sun, Y. Yang, H. Y. Zhou, Z. W. Meng, R. Chi, L. L. Xia, P. Ji, Y. Y. Chen, G. Q. Zhang, H. P. Sun, S. Lu, C. Yang, and Y. Wang. 2023. Accumulation of branched-chain amino acids reprograms glucose metabolism in CD8(+) T cells with enhanced effector function and anti-tumor response. Cell Rep 42(3):112186. https:\/\/doi.org\/10.1016\/j.celrep.2023.112186","journal-title":"Cell Rep"},{"issue":"8","key":"2439_CR9","doi-asserted-by":"publisher","first-page":"3101","DOI":"10.3390\/nu6083101","volume":"6","author":"CC Lai","year":"2014","unstructured":"Lai, C. C., W. L. Liu, and C. M. Chen. 2014. Glutamine attenuates acute lung injury caused by acid aspiration. Nutrients 6(8):3101\u20133116. https:\/\/doi.org\/10.3390\/nu6083101","journal-title":"Nutrients"},{"key":"2439_CR10","doi-asserted-by":"publisher","DOI":"10.3390\/ijms26062657","author":"D Mokra","year":"2025","unstructured":"Mokra, D., I. Porvaznik, and J. Mokry. 2025. N-Acetylcysteine in the treatment of acute lung injury: Perspectives and limitations. International Journal of Molecular Sciences. https:\/\/doi.org\/10.3390\/ijms26062657.","journal-title":"International Journal of Molecular Sciences"},{"key":"2439_CR11","doi-asserted-by":"publisher","DOI":"10.3390\/metabo14010076","author":"B Garcia","year":"2024","unstructured":"Garcia, B., E.N. Makiyama, G.R. Sampaio, R.A.M. Soares-Freitas, A. Bonvini, A.G. Amaral, S. Bordin, R.A. Fock, and M.M. Rogero. 2024. Effects of branched-chain amino acids on the inflammatory response induced by LPS in Caco-2 cells. Metabolites. https:\/\/doi.org\/10.3390\/metabo14010076.","journal-title":"Metabolites"},{"key":"2439_CR12","doi-asserted-by":"publisher","first-page":"464816","DOI":"10.1016\/j.chroma.2024.464816","volume":"1721","author":"Y Liu","year":"2024","unstructured":"Liu, Y., X. Wang, J. Wei, K. Fu, Y. Chen, L. Li, Z. Wang, and L. Yang. 2024. Comprehensive profiling of amino acids and derivatives in biological samples: A robust UHPLC-MS\/MS method for investigating acute lung injury. Journal of Chromatography A 1721:464816. https:\/\/doi.org\/10.1016\/j.chroma.2024.464816","journal-title":"Journal of Chromatography A"},{"key":"2439_CR13","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23074022","author":"A Dimou","year":"2022","unstructured":"Dimou, A., V. Tsimihodimos, and E. Bairaktari. 2022. The critical role of the branched chain amino acids (BCAAs) catabolism-regulating enzymes, branched-chain aminotransferase (BCAT) and branched-chain \u03b1-keto acid dehydrogenase (BCKD), in human pathophysiology. International Journal of Molecular Sciences. https:\/\/doi.org\/10.3390\/ijms23074022.","journal-title":"International Journal of Molecular Sciences"},{"issue":"11","key":"2439_CR14","doi-asserted-by":"publisher","first-page":"e56958","DOI":"10.15252\/embr.202356958","volume":"24","author":"H Xie","year":"2023","unstructured":"Xie, H., J. Li, N. Lian, M. Xie, M. Wu, K. Tang, Y. Kang, P. Lu, and T. Li. 2023. Defective branched-chain amino acid catabolism in dorsal root ganglia contributes to mechanical pain. Embo Reports 24(11):e56958. https:\/\/doi.org\/10.15252\/embr.202356958","journal-title":"Embo Reports"},{"key":"2439_CR15","doi-asserted-by":"publisher","first-page":"172796","DOI":"10.1016\/j.ejphar.2019.172796","volume":"866","author":"K Lian","year":"2020","unstructured":"Lian, K., X. Guo, Q. Wang, Y. Liu, R. T. Wang, C. Gao, C. Y. Li, C. X. Li, and L. Tao. 2020. PP2Cm overexpression alleviates MI\/R injury mediated by a BCAA catabolism defect and oxidative stress in diabetic mice. European Journal of Pharmacology 866:172796. https:\/\/doi.org\/10.1016\/j.ejphar.2019.172796","journal-title":"European Journal of Pharmacology"},{"issue":"5","key":"2439_CR16","doi-asserted-by":"publisher","first-page":"1151","DOI":"10.1016\/j.cmet.2018.12.020","volume":"29","author":"RE Ericksen","year":"2019","unstructured":"Ericksen, R. E., S. L. Lim, E. McDonnell, W. H. Shuen, M. Vadiveloo, P. J. White, Z. Ding, R. Kwok, P. Lee, G. K. Radda, H. C. Toh, M. D. Hirschey, and W. Han. 2019. Loss of BCAA catabolism during carcinogenesis enhances mTORC1 activity and promotes tumor development and progression. Cell Metab 29(5):1151\u20131165e1156. https:\/\/doi.org\/10.1016\/j.cmet.2018.12.020","journal-title":"Cell Metab"},{"issue":"38","key":"2439_CR17","doi-asserted-by":"publisher","first-page":"e02624","DOI":"10.1002\/advs.202502624","volume":"12","author":"Y Chen","year":"2025","unstructured":"Chen, Y., S. Jiang, H. Wang, M. Si, H. Wu, X. Liang, S. Yao, Y. Zhang, X. Wen, and J. Yang. 2025. The probiotic Parabacteroides johnsonii ameliorates metabolic disorders through promoting BCAAs to BSCFAs conversion. Advanced Science: e02624. https:\/\/doi.org\/10.1002\/advs.202502624.","journal-title":"Advanced Science"},{"key":"2439_CR18","doi-asserted-by":"publisher","first-page":"156037","DOI":"10.1016\/j.metabol.2024.156037","volume":"162","author":"X Deng","year":"2025","unstructured":"Deng, X., C. Tang, T. Fang, T. Li, X. Li, Y. Liu, X. Zhang, B. Sun, H. Sun, and L. Chen. 2025. Disruption of branched-chain amino acid homeostasis promotes the progression of DKD via enhancing inflammation and fibrosis-associated epithelial-mesenchymal transition. Metabolism 162:156037. https:\/\/doi.org\/10.1016\/j.metabol.2024.156037","journal-title":"Metabolism"},{"key":"2439_CR19","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24065093","author":"K Lai","year":"2023","unstructured":"Lai, K., C. Song, M. Gao, Y. Deng, Z. Lu, N. Li, and Q. Geng. 2023. Uridine alleviates sepsis-induced acute lung injury by inhibiting ferroptosis of macrophage. International Journal of Molecular Sciences. https:\/\/doi.org\/10.3390\/ijms24065093.","journal-title":"International Journal of Molecular Sciences"},{"issue":"1","key":"2439_CR20","doi-asserted-by":"publisher","first-page":"242","DOI":"10.7150\/ijbs.77304","volume":"19","author":"WJ Zhong","year":"2023","unstructured":"Zhong, W. J., T. Liu, H. H. Yang, J. X. Duan, J. T. Yang, X. X. Guan, J. B. Xiong, Y. F. Zhang, C. Y. Zhang, Y. Zhou, and C. X. Guan. 2023. TREM-1 governs NLRP3 inflammasome activation of macrophages by firing up Glycolysis in acute lung injury. International Journal of Biological Sciences 19(1):242\u2013257. https:\/\/doi.org\/10.7150\/ijbs.77304","journal-title":"International Journal of Biological Sciences"},{"key":"2439_CR21","doi-asserted-by":"publisher","first-page":"102513","DOI":"10.1016\/j.redox.2022.102513","volume":"58","author":"R Chen","year":"2022","unstructured":"Chen, R., C. Cao, H. Liu, W. Jiang, R. Pan, H. He, K. Ding, and Q. Meng. 2022. Macrophage Sprouty4 deficiency diminishes sepsis-induced acute lung injury in mice. Redox Biology 58:102513. https:\/\/doi.org\/10.1016\/j.redox.2022.102513","journal-title":"Redox Biology"},{"issue":"1","key":"2439_CR22","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1182\/blood.2023020484","volume":"143","author":"S van der Velden","year":"2024","unstructured":"van der Velden, S., T. L. J. van Osch, A. Seghier, A. E. H. Bentlage, J. Y. Mok, D. M. Geerdes, W. J. E. van Esch, R. B. Pouw, M. C. Brouwer, I. Jongerius, M. de Haas, L. Porcelijn, C. E. van der Schoot, G. Vidarsson, and R. Kapur. 2024. Complement activation drives antibody-mediated transfusion-related acute lung injury via macrophage trafficking and formation of NETs. Blood 143(1):79\u201391. https:\/\/doi.org\/10.1182\/blood.2023020484","journal-title":"Blood"},{"key":"2439_CR23","doi-asserted-by":"publisher","first-page":"222","DOI":"10.1016\/j.freeradbiomed.2019.11.011","volume":"146","author":"XT Huang","year":"2020","unstructured":"Huang, X. T., W. Liu, Y. Zhou, M. Sun, H. H. Yang, C. Y. Zhang, and S. Y. Tang. 2020. Galectin-1 ameliorates lipopolysaccharide-induced acute lung injury via AMPK-Nrf2 pathway in mice. Free Radical Biology and Medicine 146:222\u2013233. https:\/\/doi.org\/10.1016\/j.freeradbiomed.2019.11.011","journal-title":"Free Radical Biology and Medicine"},{"issue":"1","key":"2439_CR24","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1186\/s11658-023-00505-1","volume":"28","author":"Y Xu","year":"2023","unstructured":"Xu, Y., C. Zhang, D. Cai, R. Zhu, and Y. Cao. 2023. Exosomal miR-155-5p drives widespread macrophage M1 polarization in hypervirulent Klebsiella pneumoniae-induced acute lung injury via the MSK1\/p38-MAPK axis. Cellular & Molecular Biology Letters 28 (1): 92. https:\/\/doi.org\/10.1186\/s11658-023-00505-1.","journal-title":"Cellular & Molecular Biology Letters"},{"key":"2439_CR25","doi-asserted-by":"publisher","first-page":"154143","DOI":"10.1016\/j.phymed.2022.154143","volume":"101","author":"H Hong","year":"2022","unstructured":"Hong, H., S. Lou, F. Zheng, H. Gao, N. Wang, S. Tian, G. Huang, and H. Zhao. 2022. Hydnocarpin D attenuates lipopolysaccharide-induced acute lung injury via MAPK\/NF-\u03baB and Keap1\/Nrf2\/HO-1 pathway. Phytomedicine 101:154143. https:\/\/doi.org\/10.1016\/j.phymed.2022.154143","journal-title":"Phytomedicine"},{"key":"2439_CR26","doi-asserted-by":"publisher","first-page":"115725","DOI":"10.1016\/j.jep.2022.115725","volume":"300","author":"C Chen","year":"2023","unstructured":"Chen, C., L. Li, X. Liu, D. Zhang, Y. Liu, and Y. Li. 2023. 23-O-acetylshengmanol-3-O-\u03b1-L-arabinoside alleviates lipopolysaccharide-induced acute lung injury through inhibiting I\u03baB\/NF-\u03baB and MAPK\/AP-1 signaling pathways. Journal of Ethnopharmacology 300:115725. https:\/\/doi.org\/10.1016\/j.jep.2022.115725","journal-title":"Journal of Ethnopharmacology"},{"key":"2439_CR27","doi-asserted-by":"publisher","first-page":"154545","DOI":"10.1016\/j.phymed.2022.154545","volume":"108","author":"Z Li","year":"2023","unstructured":"Li, Z., H. Pan, J. Yang, D. Chen, Y. Wang, H. Zhang, and Y. Cheng. 2023. Xuanfei baidu formula alleviates impaired mitochondrial dynamics and activated NLRP3 inflammasome by repressing NF-\u03baB and MAPK pathways in LPS-induced ALI and inflammation models. Phytomedicine 108: 154545. https:\/\/doi.org\/10.1016\/j.phymed.2022.154545.","journal-title":"Phytomedicine"},{"key":"2439_CR28","doi-asserted-by":"publisher","first-page":"106351","DOI":"10.1016\/j.bioorg.2023.106351","volume":"132","author":"X Pei","year":"2023","unstructured":"Pei, X., Z. Zhang, N. Wang, G. Huang, X. Min, Y. Yang, and J. Cao. 2023. Onychiol B attenuates lipopolysaccharide-induced inflammation via MAPK\/NF-\u03baB pathways and acute lung injury in vivo. Bioorganic Chemistry 132:106351. https:\/\/doi.org\/10.1016\/j.bioorg.2023.106351","journal-title":"Bioorganic Chemistry"},{"issue":"21","key":"2439_CR29","doi-asserted-by":"publisher","first-page":"5018","DOI":"10.1038\/s44318-024-00220-3","volume":"43","author":"JW Shi","year":"2024","unstructured":"Shi, J. W., Z. Z. Lai, W. J. Zhou, H. L. Yang, T. Zhang, J. S. Sun, J. Y. Zhao, and M. Q. Li. 2024. TNFSF14(+) natural killer cells prevent spontaneous abortion by restricting leucine-mediated decidual stromal cell senescence. Embo Journal 43(21):5018\u20135036. https:\/\/doi.org\/10.1038\/s44318-024-00220-3","journal-title":"Embo Journal"},{"key":"2439_CR30","doi-asserted-by":"publisher","DOI":"10.3390\/nu17081335","author":"M Xu","year":"2025","unstructured":"Xu, M., D. Hu, X. Liu, Z. Li, and L. Lu. 2025. Branched-chain amino acids and inflammation management in endurance sports: Molecular mechanisms and practical implications. Nutrients. https:\/\/doi.org\/10.3390\/nu17081335.","journal-title":"Nutrients"},{"issue":"1","key":"2439_CR31","doi-asserted-by":"publisher","first-page":"566","DOI":"10.1186\/s12964-024-01946-7","volume":"22","author":"CY Zhang","year":"2024","unstructured":"Zhang, C. Y., A. J. Ou, L. Jin, N. S. Yang, P. Deng, C. X. Guan, X. T. Huang, J. X. Duan, and Y. Zhou. 2024. Cadmium exposure triggers alveolar epithelial cell pyroptosis by inducing mitochondrial oxidative stress and activating the cGAS-STING pathway. Cell Commun Signal 22(1):566. https:\/\/doi.org\/10.1186\/s12964-024-01946-7","journal-title":"Cell Commun Signal"},{"issue":"1","key":"2439_CR32","doi-asserted-by":"publisher","first-page":"1600","DOI":"10.1038\/s41598-024-52042-2","volume":"14","author":"GY Wang","year":"2024","unstructured":"Wang, G. Y., X. Xu, D. Y. Xiong, L. Deng, W. Liu, and X. T. Huang. 2024. CPT1A as a potential therapeutic target for lipopolysaccharide-induced acute lung injury in mice. Scientific Reports 14(1):1600. https:\/\/doi.org\/10.1038\/s41598-024-52042-2","journal-title":"Scientific Reports"},{"key":"2439_CR33","doi-asserted-by":"publisher","first-page":"1321095","DOI":"10.3389\/fphar.2024.1321095","volume":"15","author":"M Zhou","year":"2024","unstructured":"Zhou, M., L. Meng, Q. He, C. Ren, and C. Li. 2024. Valsartan attenuates LPS-induced ALI by modulating NF-\u03baB and MAPK pathways. Frontiers in Pharmacology 15:1321095. https:\/\/doi.org\/10.3389\/fphar.2024.1321095","journal-title":"Frontiers in Pharmacology"},{"issue":"19","key":"2439_CR34","doi-asserted-by":"publisher","first-page":"7333","DOI":"10.7150\/thno.102708","volume":"14","author":"ZY Zhou","year":"2024","unstructured":"Zhou, Z. Y., K. Song, Z. Y. Liu, Y. F. Ke, Y. Shi, K. Cai, R. Zhao, X. Sun, H. Tao, and J. Y. Zhao. 2024. Branched-chain amino acids deficiency promotes diabetic cardiomyopathy by activating autophagy of cardiac fibroblasts. Theranostics 14(19):7333\u20137348. https:\/\/doi.org\/10.7150\/thno.102708","journal-title":"Theranostics"},{"issue":"7","key":"2439_CR35","doi-asserted-by":"publisher","first-page":"e031617","DOI":"10.1161\/JAHA.123.031617","volume":"13","author":"KS Fine","year":"2024","unstructured":"Fine, K. S., J. T. Wilkins, and K. T. Sawicki. 2024. Circulating branched chain amino acids and cardiometabolic disease. J Am Heart Assoc 13(7):e031617. https:\/\/doi.org\/10.1161\/JAHA.123.031617","journal-title":"J Am Heart Assoc"},{"issue":"9","key":"2439_CR36","doi-asserted-by":"publisher","first-page":"1519","DOI":"10.1016\/j.chom.2024.07.012","volume":"32","author":"YM Ren","year":"2024","unstructured":"Ren, Y. M., Z. Y. Zhuang, Y. H. Xie, P. J. Yang, T. X. Xia, Y. L. Xie, Z. H. Liu, Z. R. Kang, X. X. Leng, S. Y. Lu, L. Zhang, J. X. Chen, J. Xu, E. H. Zhao, Z. Wang, M. Wang, Y. Cui, J. Tan, Q. Liu, W. H. Jiang, H. Xiong, J. Hong, Y. X. Chen, H. Y. Chen, and J. Y. Fang. 2024. BCAA-producing clostridium symbiosum promotes colorectal tumorigenesis through the modulation of host cholesterol metabolism. Cell Host & Microbe 32(9):1519\u20131535e1517. https:\/\/doi.org\/10.1016\/j.chom.2024.07.012","journal-title":"Cell Host & Microbe"},{"issue":"2","key":"2439_CR37","doi-asserted-by":"publisher","first-page":"e13856","DOI":"10.1111\/obr.13856","volume":"26","author":"S Mansoori","year":"2025","unstructured":"Mansoori, S., M. Y. Ho, K. K. Ng, and K. K. Cheng. 2025. Branched-chain amino acid metabolism: Pathophysiological mechanism and therapeutic intervention in metabolic diseases. Obesity Reviews 26(2):e13856. https:\/\/doi.org\/10.1111\/obr.13856","journal-title":"Obesity Reviews"},{"key":"2439_CR38","doi-asserted-by":"publisher","first-page":"258","DOI":"10.1016\/j.actbio.2022.06.024","volume":"148","author":"W Muhammad","year":"2022","unstructured":"Muhammad, W., J. Zhu, Z. Zhai, J. Xie, J. Zhou, X. Feng, B. Feng, Q. Pan, S. Li, R. Venkatesan, P. Li, H. Cao, and C. Gao. 2022. ROS-responsive polymer nanoparticles with enhanced loading of dexamethasone effectively modulate the lung injury microenvironment. Acta Biomaterialia 148:258\u2013270. https:\/\/doi.org\/10.1016\/j.actbio.2022.06.024","journal-title":"Acta Biomaterialia"},{"issue":"1","key":"2439_CR39","doi-asserted-by":"publisher","first-page":"7703","DOI":"10.1038\/s41467-022-35492-y","volume":"13","author":"K Wang","year":"2022","unstructured":"Wang, K., M. Wang, X. Liao, S. Gao, J. Hua, X. Wu, Q. Guo, W. Xu, J. Sun, Y. He, Q. Li, and W. Gao. 2022. Locally organised and activated Fth1(hi) neutrophils aggravate inflammation of acute lung injury in an IL-10-dependent manner. Nature Communications 13(1):7703. https:\/\/doi.org\/10.1038\/s41467-022-35492-y","journal-title":"Nature Communications"},{"key":"2439_CR40","doi-asserted-by":"publisher","DOI":"10.3390\/cells11203317","author":"MW Millar","year":"2022","unstructured":"Millar, M.W., F. Fazal, and A. Rahman. 2022. Therapeutic targeting of NF-\u03baB in acute lung injury: A double-edged sword. Cells. https:\/\/doi.org\/10.3390\/cells11203317.","journal-title":"Cells"},{"issue":"8","key":"2439_CR41","doi-asserted-by":"publisher","first-page":"686","DOI":"10.1038\/s41419-022-05134-8","volume":"13","author":"L Qu","year":"2022","unstructured":"Qu, L., Y. Li, C. Chen, T. Yin, Q. Fang, Y. Zhao, W. Lv, Z. Liu, Y. Chen, and L. Shen. 2022. Caveolin-1 identified as a key mediator of acute lung injury using bioinformatics and functional research. Cell Death and Disease 13(8):686. https:\/\/doi.org\/10.1038\/s41419-022-05134-8","journal-title":"Cell Death and Disease"},{"key":"2439_CR42","doi-asserted-by":"publisher","first-page":"105709","DOI":"10.1016\/j.tiv.2023.105709","volume":"94","author":"B Sun","year":"2024","unstructured":"Sun, B., L. Bai, Q. Li, Y. Sun, M. Li, J. Wang, X. Shi, and M. Zhao. 2024. Knockdown of angiopoietin-like 4 suppresses sepsis-induced acute lung injury by blocking the NF-\u03baB pathway activation and hindering macrophage M1 polarization and pyroptosis. Toxicology in Vitro 94:105709. https:\/\/doi.org\/10.1016\/j.tiv.2023.105709","journal-title":"Toxicology in Vitro"},{"issue":"1","key":"2439_CR43","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1186\/s12967-021-02745-1","volume":"19","author":"J Li","year":"2021","unstructured":"Li, J., K. Lu, F. Sun, S. Tan, X. Zhang, W. Sheng, W. Hao, M. Liu, W. Lv, and W. Han. 2021. Panaxydol attenuates ferroptosis against LPS-induced acute lung injury in mice by Keap1-Nrf2\/HO-1 pathway. Journal of Translational Medicine 19 (1): 96. https:\/\/doi.org\/10.1186\/s12967-021-02745-1.","journal-title":"Journal of Translational Medicine"},{"issue":"1","key":"2439_CR44","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1021\/acscentsci.1c00866","volume":"8","author":"R Yuan","year":"2022","unstructured":"Yuan, R., Y. Li, S. Han, X. Chen, J. Chen, J. He, H. Gao, Y. Yang, S. Yang, and Y. Yang. 2022. Fe-curcumin nanozyme-mediated reactive oxygen species scavenging and anti-inflammation for acute lung injury. ACS Central Science 8 (1): 10\u201321. https:\/\/doi.org\/10.1021\/acscentsci.1c00866.","journal-title":"ACS Central Science"},{"issue":"6","key":"2439_CR45","doi-asserted-by":"publisher","first-page":"1875","DOI":"10.1007\/s11011-022-00996-5","volume":"37","author":"GDS Feij\u00f3","year":"2022","unstructured":"Feij\u00f3, G. D. S., J. Jantsch, L. L. Correia, S. Eller, O. V. Furtado-Filho, M. Giovenardi, M. Porawski, E. Braganhol, and R. P. Guedes. 2022. Neuroinflammatory responses following zinc or branched-chain amino acids supplementation in obese rats. Metabolic Brain Disease 37(6):1875\u20131886. https:\/\/doi.org\/10.1007\/s11011-022-00996-5","journal-title":"Metabolic Brain Disease"},{"key":"2439_CR46","doi-asserted-by":"publisher","first-page":"171015","DOI":"10.1016\/j.scitotenv.2024.171015","volume":"922","author":"FW Jiang","year":"2024","unstructured":"Jiang, F. W., J. Y. Guo, J. Lin, S. Y. Zhu, X. Y. Dai, M. A. U. Saleem, Y. Zhao, and J. L. Li. 2024. MAPK\/NF-\u03baB signaling mediates atrazine-induced cardiorenal syndrome and antagonism of lycopene. Science of the Total Environment 922:171015. https:\/\/doi.org\/10.1016\/j.scitotenv.2024.171015","journal-title":"Science of the Total Environment"},{"issue":"6","key":"2439_CR47","doi-asserted-by":"publisher","first-page":"1131","DOI":"10.1007\/s10557-022-07356-6","volume":"37","author":"Y Chen","year":"2023","unstructured":"Chen, Y., W. Lin, L. Zhong, Z. Fang, B. Ye, Z. Wang, N. Chattipakorn, W. Huang, G. Liang, and G. Wu. 2023. Bicyclol attenuates obesity-induced cardiomyopathy via inhibiting NF-\u03baB and MAPK signaling pathways. Cardiovascular Drugs and Therapy 37 (6): 1131\u20131141. https:\/\/doi.org\/10.1007\/s10557-022-07356-6.","journal-title":"Cardiovascular Drugs and Therapy"},{"issue":"2","key":"2439_CR48","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1016\/j.kint.2017.01.021","volume":"92","author":"J Yamamoto","year":"2017","unstructured":"Yamamoto, J., S. Nishio, F. Hattanda, D. Nakazawa, T. Kimura, M. Sata, M. Makita, Y. Ishikawa, and T. Atsumi. 2017. Branched-chain amino acids enhance cyst development in autosomal dominant polycystic kidney disease. Kidney International 92(2):377\u2013387. https:\/\/doi.org\/10.1016\/j.kint.2017.01.021","journal-title":"Kidney International"},{"issue":"28","key":"2439_CR49","doi-asserted-by":"publisher","first-page":"26127","DOI":"10.1021\/acsnano.5c07535","volume":"19","author":"S Chen","year":"2025","unstructured":"Chen, S., X. Liu, W. Zhang, B. Li, F. Liu, Y. Zhang, and Y. Han. 2025. Nanozyme coating-mediated mitochondrial metabolic reprogramming of macrophages for immunomodulatory osseointegration in rheumatoid arthritis case. ACS Nano 19 (28): 26127\u201326146. https:\/\/doi.org\/10.1021\/acsnano.5c07535.","journal-title":"ACS Nano"},{"key":"2439_CR50","doi-asserted-by":"publisher","first-page":"1469163","DOI":"10.3389\/fimmu.2024.1469163","volume":"15","author":"M Lu","year":"2024","unstructured":"Lu, M., D. Luo, Z. Zhang, F. Ouyang, Y. Shi, C. Hu, H. Su, Y. Li, J. Zhang, Q. Gui, and T. S. Yang. 2024. Branched-chain amino acid catabolism promotes M2 macrophage polarization. Frontiers in Immunology 15:1469163. https:\/\/doi.org\/10.3389\/fimmu.2024.1469163","journal-title":"Frontiers in Immunology"},{"key":"2439_CR51","doi-asserted-by":"publisher","first-page":"102696","DOI":"10.1016\/j.redox.2023.102696","volume":"62","author":"S Zhao","year":"2023","unstructured":"Zhao, S., L. Zhou, Q. Wang, J. H. Cao, Y. Chen, W. Wang, B. D. Zhu, Z. H. Wei, R. Li, C. Y. Li, G. Y. Zhou, Z. J. Tan, H. P. Zhou, C. X. Li, H. K. Gao, X. J. Qin, and K. Lian. 2023. Elevated branched-chain amino acid promotes atherosclerosis progression by enhancing mitochondrial-to-nuclear H(2)O(2)-disulfide HMGB1 in macrophages. Redox Biology 62:102696. https:\/\/doi.org\/10.1016\/j.redox.2023.102696","journal-title":"Redox Biology"}],"container-title":["Inflammation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10753-025-02439-6","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10753-025-02439-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10753-025-02439-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T22:06:55Z","timestamp":1771538815000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10753-025-02439-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,4]]},"references-count":51,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["2439"],"URL":"https:\/\/doi.org\/10.1007\/s10753-025-02439-6","relation":{},"ISSN":["1573-2576"],"issn-type":[{"value":"1573-2576","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,4]]},"assertion":[{"value":"22 October 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 December 2025","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 December 2025","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 February 2026","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study was performed in line with the principles of the Declaration of Helsinki. Approval was granted by the Ethics Committee of Central South University (XMSB-2024-0011).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics Approval"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"83"}}