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The submission and approval of the ethical guidelines comply with the Declaration of Helsinki. The ethical approval number is CYFYLL2024077. The animal use and care plan adheres to the National Institutes of Health (NIH) Guide for the Care and Use of Laboratory Animals. All animal experiments in this study were approved by the Animal Care and Use Committee of the Affiliated Hospital of Chengde Medical University. The ethical approval number is CYFYLL2025006.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"The authors declare no conflicts of interest.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Clinical trial number"}}],"article-number":"117"}}