{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T01:37:00Z","timestamp":1785461820708,"version":"3.56.0"},"reference-count":21,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,2,9]],"date-time":"2026-02-09T00:00:00Z","timestamp":1770595200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T00:00:00Z","timestamp":1771545600000},"content-version":"vor","delay-in-days":11,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81870390"],"award-info":[{"award-number":["81870390"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82172983"],"award-info":[{"award-number":["82172983"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Inflammation"],"DOI":"10.1007\/s10753-026-02461-2","type":"journal-article","created":{"date-parts":[[2026,2,8]],"date-time":"2026-02-08T23:22:10Z","timestamp":1770592930000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["NLRP12 Deficiency Enhances Tofacitinib Efficacy in DSS Colitis Via STAT1-M1 Polarization"],"prefix":"10.1007","volume":"49","author":[{"given":"Yun","family":"Yi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiaofang","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siyu","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lurao","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wangdron","family":"Dekyi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hangqi","family":"Jia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiawen","family":"Shu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiu","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,2,9]]},"reference":[{"issue":"7796","key":"2461_CR1","doi-asserted-by":"publisher","first-page":"527","DOI":"10.1038\/s41586-020-2025-2","volume":"578","author":"DB Graham","year":"2020","unstructured":"Graham, D.B., and R.J. Xavier. 2020. Pathway paradigms revealed from the genetics of inflammatory bowel disease. Nature 578 (7796): 527\u201339.","journal-title":"Nature"},{"issue":"3","key":"2461_CR2","doi-asserted-by":"publisher","first-page":"384","DOI":"10.14309\/ajg.0000000000000152","volume":"114","author":"DT Rubin","year":"2019","unstructured":"Rubin, D.T., A.N. Ananthakrishnan, C.A. Siegel, B.G. Sauer, and M.D. Long. 2019. ACG clinical guideline: Ulcerative colitis in adults. American Journal of Gastroenterology 114 (3): 384\u2013413.","journal-title":"American Journal of Gastroenterology"},{"issue":"1","key":"2461_CR3","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1111\/apt.15592","volume":"51","author":"C Dong","year":"2020","unstructured":"Dong, C., M. Metzger, E. Holsb\u00f8, V. Perduca, and F. Carbonnel. 2020. Systematic review with meta-analysis: Mortality in acute severe ulcerative colitis. Alimentary Pharmacology & Therapeutics 51(1):8\u201333.","journal-title":"Alimentary Pharmacology & Therapeutics"},{"issue":"18","key":"2461_CR4","doi-asserted-by":"publisher","first-page":"1723","DOI":"10.1056\/NEJMoa1606910","volume":"376","author":"WJ Sandborn","year":"2017","unstructured":"Sandborn, W. J., C. Su, B. E. Sands, G. R. D\u2019Haens, S. Vermeire, and S. Schreiber et al. 2017. Tofacitinib as induction and maintenance therapy for ulcerative colitis. New England Journal of Medicine 376(18):1723\u20131736.","journal-title":"New England Journal of Medicine"},{"issue":"2","key":"2461_CR5","doi-asserted-by":"publisher","first-page":"300","DOI":"10.1093\/ecco-jcc\/jjad153","volume":"18","author":"A Singh","year":"2024","unstructured":"Singh, A., V. Midha, K. Kaur, R. Mahajan, D. Singh, and R. Kaur et al. 2024. Tofacitinib versus oral prednisolone for induction of remission in moderately active ulcerative colitis [ORCHID]: A Prospective, Open-Label, Randomized, pilot study. J Crohns Colitis 18(2):300\u2013307.","journal-title":"J Crohns Colitis"},{"issue":"8","key":"2461_CR6","doi-asserted-by":"publisher","first-page":"1821","DOI":"10.1016\/j.cgh.2020.10.038","volume":"20","author":"WJ Sandborn","year":"2022","unstructured":"Sandborn, W. J., L. Peyrin-Biroulet, D. Quirk, W. Wang, C. I. Nduaka, and A. Mukherjee et al. 2022. Efficacy and safety of extended induction with Tofacitinib for the treatment of ulcerative colitis. Clinical Gastroenterology and Hepatology 20(8):1821\u201330e3.","journal-title":"Clinical Gastroenterology and Hepatology"},{"key":"2461_CR7","doi-asserted-by":"publisher","first-page":"100887","DOI":"10.1016\/j.mam.2020.100887","volume":"76","author":"S Tuladhar","year":"2020","unstructured":"Tuladhar, S., and T. D. Kanneganti. 2020. NLRP12 in innate immunity and inflammation. Molecular Aspects of Medicine 76:100887.","journal-title":"Molecular Aspects of Medicine"},{"issue":"5","key":"2461_CR8","doi-asserted-by":"publisher","first-page":"649","DOI":"10.1016\/j.ccr.2011.10.022","volume":"20","author":"MH Zaki","year":"2011","unstructured":"Zaki, M. H., P. Vogel, R. K. Malireddi, M. Body-Malapel, P. K. Anand, and J. Bertin et al. 2011. The NOD-like receptor NLRP12 attenuates colon inflammation and tumorigenesis. Cancer Cell 20(5):649\u2013660.","journal-title":"Cancer Cell"},{"issue":"5","key":"2461_CR9","doi-asserted-by":"publisher","first-page":"742","DOI":"10.1016\/j.immuni.2012.03.012","volume":"36","author":"IC Allen","year":"2012","unstructured":"Allen, I. C., J. E. Wilson, M. Schneider, J. D. Lich, R. A. Roberts, and J. C. Arthur et al. 2012. NLRP12 suppresses colon inflammation and tumorigenesis through the negative regulation of noncanonical NF-\u03baB signaling. Immunity 36(5):742\u2013754.","journal-title":"Immunity"},{"issue":"3","key":"2461_CR10","doi-asserted-by":"publisher","first-page":"364","DOI":"10.1016\/j.chom.2018.08.009","volume":"24","author":"AD Truax","year":"2018","unstructured":"Truax, A. D., L. Chen, J. W. Tam, N. Cheng, H. Guo, and A. A. Koblansky et al. 2018. The inhibitory innate immune sensor NLRP12 maintains a threshold against obesity by regulating gut microbiota homeostasis. Cell Host & Microbe 24(3):364\u201378e6.","journal-title":"Cell Host & Microbe"},{"issue":"8","key":"2461_CR11","doi-asserted-by":"publisher","first-page":"1283","DOI":"10.1093\/ecco-jcc\/jjae031","volume":"18","author":"S van Gennep","year":"2024","unstructured":"van Gennep, S., I. C. N. Fung, D. C. Jong, R. K. Ramkisoen, E. Clasquin, and J. de Jong et al. 2024. Histological outcomes and JAK-STAT signalling in ulcerative colitis patients treated with Tofacitinib. J Crohns Colitis 18(8):1283\u20131291.","journal-title":"J Crohns Colitis"},{"issue":"1","key":"2461_CR12","doi-asserted-by":"publisher","first-page":"919","DOI":"10.1186\/s12967-023-04799-9","volume":"21","author":"C Wang","year":"2023","unstructured":"Wang, C., H. Kang, Y. Yi, Y. Ding, F. Wang, and J. Luo et al. 2023. Rictor mediates p53 deactivation to facilitate the malignant transformation of hepatocytes and promote hepatocarcinogenesis. J Transl Med 21(1):919.","journal-title":"J Transl Med"},{"issue":"3","key":"2461_CR13","doi-asserted-by":"publisher","first-page":"1256","DOI":"10.4049\/jimmunol.178.3.1256","volume":"178","author":"JD Lich","year":"2007","unstructured":"Lich, J. D., K. L. Williams, C. B. Moore, J. C. Arthur, B. K. Davis, and D. J. Taxman et al. 2007. Monarch-1 suppresses non-canonical NF-kappaB activation and p52-dependent chemokine expression in monocytes. The Journal of Immunology 178(3):1256\u20131260.","journal-title":"The Journal of Immunology"},{"issue":"1","key":"2461_CR14","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1016\/j.immuni.2012.07.006","volume":"37","author":"GI Vladimer","year":"2012","unstructured":"Vladimer, G. I., D. Weng, S. W. Paquette, S. K. Vanaja, V. A. Rathinam, and M. H. Aune et al. 2012. The NLRP12 inflammasome recognizes yersinia pestis. Immunity 37(1):96\u2013107.","journal-title":"Immunity"},{"issue":"1","key":"2461_CR15","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-024-01757-9","volume":"9","author":"Q Guo","year":"2024","unstructured":"Guo, Q., Y. Jin, X. Chen, X. Ye, X. Shen, M. Lin, et al. 2024. NF-\u03baB in biology and targeted therapy: New insights and translational implications. Signal Transduction and Targeted Therapy 9 (1): 53.","journal-title":"Signal Transduction and Targeted Therapy"},{"issue":"1","key":"2461_CR16","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1038\/s41392-021-00791-1","volume":"6","author":"X Hu","year":"2021","unstructured":"Hu, X., J. Li, M. Fu, X. Zhao, and W. Wang. 2021. The JAK\/STAT signaling pathway: From bench to clinic. Signal Transduction and Targeted Therapy 6 (1): 402.","journal-title":"Signal Transduction and Targeted Therapy"},{"issue":"1","key":"2461_CR17","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/j.autrev.2013.06.004","volume":"13","author":"A Geremia","year":"2014","unstructured":"Geremia, A., P. Biancheri, P. Allan, G.R. Corazza, and A. Di Sabatino. 2014. Innate and adaptive immunity in inflammatory bowel disease. Autoimmunity Reviews 13 (1): 3\u201310.","journal-title":"Autoimmunity Reviews"},{"issue":"1","key":"2461_CR18","doi-asserted-by":"publisher","first-page":"3675","DOI":"10.1038\/s41467-023-39173-2","volume":"14","author":"J Du","year":"2023","unstructured":"Du, J., J. Zhang, L. Wang, X. Wang, Y. Zhao, and J. Lu et al. 2023. Selective oxidative protection leads to tissue topological changes orchestrated by macrophage during ulcerative colitis. Nature Communications 14(1):3675.","journal-title":"Nature Communications"},{"issue":"12","key":"2461_CR19","doi-asserted-by":"publisher","first-page":"958","DOI":"10.1038\/nri2448","volume":"8","author":"DM Mosser","year":"2008","unstructured":"Mosser, D.M., and J.P. Edwards. 2008. Exploring the full spectrum of macrophage activation. Nature Reviews Immunology 8 (12): 958\u201369.","journal-title":"Nature Reviews Immunology"},{"issue":"2","key":"2461_CR20","doi-asserted-by":"publisher","first-page":"186","DOI":"10.1111\/imm.12910","volume":"154","author":"SC Funes","year":"2018","unstructured":"Funes, S.C., M. Rios, J. Escobar-Vera, and A.M. Kalergis. 2018. Implications of macrophage polarization in autoimmunity. Immunology 154 (2): 186\u201395.","journal-title":"Immunology"},{"issue":"7","key":"2461_CR21","doi-asserted-by":"publisher","first-page":"1151","DOI":"10.1093\/ibd\/izad290","volume":"30","author":"I Lethen","year":"2024","unstructured":"Lethen, I., K. Lechner-Grimm, M. Gabel, A. Knauss, R. Atreya, and M. F. Neurath et al. 2024. Tofacitinib affects M1-like and M2-like polarization and tissue factor expression in macrophages of healthy donors and IBD patients. Inflammatory Bowel Diseases 30(7):1151\u20131163.","journal-title":"Inflammatory Bowel Diseases"}],"container-title":["Inflammation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10753-026-02461-2","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10753-026-02461-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10753-026-02461-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T01:02:10Z","timestamp":1771549330000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10753-026-02461-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,9]]},"references-count":21,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["2461"],"URL":"https:\/\/doi.org\/10.1007\/s10753-026-02461-2","relation":{},"ISSN":["1573-2576"],"issn-type":[{"value":"1573-2576","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,9]]},"assertion":[{"value":"4 October 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"31 December 2025","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 January 2026","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 February 2026","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The animal experiment conduction in this study were obtained under an approved institutional review board protocol.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics Approval and Consent to Participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for Publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing Interests"}}],"article-number":"85"}}