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All human samples used in the present study were obtained under the approval of the Committee for Clinical Investigation of the First Affiliated Hospital, Sun Yat-sen University (approval numbers: IIT-2021\u2013654, 2019\u201355) and conformed to the principles of the Declaration of Helsinki. Informed consent was obtained from each subject for the use of samples.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics Approval"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"148"}}