{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T18:44:07Z","timestamp":1791053047774,"version":"4.1.0"},"reference-count":58,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T00:00:00Z","timestamp":1778544000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T00:00:00Z","timestamp":1783296000000},"content-version":"vor","delay-in-days":55,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100001774","name":"The University of Sydney","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100001774","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Inflammation"],"DOI":"10.1007\/s10753-026-02523-5","type":"journal-article","created":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T16:54:43Z","timestamp":1778604883000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Erosion or Explosion: Integrated Single-Cell Transcriptomics Reveals Cellular Heterogeneity in Aortic Aneurysm and Dissection"],"prefix":"10.1007","volume":"49","author":[{"given":"Heng","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keyi","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaling","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziyan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keyang","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maolin","family":"Qiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taoran","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chaonan","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guoping","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,5,12]]},"reference":[{"key":"2523_CR1","doi-asserted-by":"publisher","first-page":"3538","DOI":"10.1093\/eurheartj\/ehae179","volume":"45","author":"L Mazzolai","year":"2024","unstructured":"Mazzolai, L., G. Teixido-Tura, S. Lanzi, V. Boc, E. Bossone, M. Brodmann, A. Bura-Rivi\u00e8re, J. De Backer, S. Deglise, and A. Della Corte et al. 2024. 2024 ESC Guidelines for the management of peripheral arterial and aortic diseases. European Heart Journal 45:3538\u20133700.","journal-title":"European Heart Journal"},{"key":"2523_CR2","doi-asserted-by":"crossref","unstructured":"Isselbacher, E. M., O. Preventza, J. 3 Hamilton Black rd, J. G. Augoustides, A. W. Beck, M. A. Bolen, A. C. Braverman, B. E. Bray, M. M. Brown-Zimmerman, and E. P. Chen et al. 2022. 2022 ACC\/AHA Guideline for the Diagnosis and Management of Aortic Disease: A Report of the American Heart Association\/American College of Cardiology Joint Committee on Clinical Practice Guidelines. Circulation 146:e334\u2013e482.","DOI":"10.1161\/CIR.0000000000001097"},{"key":"2523_CR3","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1007\/s44197-025-00369-y","volume":"15","author":"H Wang","year":"2025","unstructured":"Wang, H., Y. Li, K. Fan, T. Zhao, K. Xu, M. Zahin, S. Wang, G. Cao, T. Gao, and X. Jia et al. 2025. Global Epidemiology of Early-Onset Aortic Aneurysm: Temporal Trends, Risk Factors, and Future Burden Projections. J Epidemiol Glob Health 15:25.","journal-title":"J Epidemiol Glob Health"},{"key":"2523_CR4","doi-asserted-by":"publisher","first-page":"2575807","DOI":"10.1080\/09581596.2025.2575807","volume":"35","author":"K Fan","year":"2025","unstructured":"Fan, K., H. Wang, Y. Li, Z. Wang, Y. Shi, S. Sun, Z. Guo, M. Zahin, T. Zhao, and R. Zhang et al. 2025. Global landscape of mortality and risk factors for aortic aneurysm in adults aged 55 years and older: insights from the global burden of disease study 2021. Critical Public Health 35:2575807.","journal-title":"Critical Public Health"},{"key":"2523_CR5","doi-asserted-by":"publisher","first-page":"569639","DOI":"10.2147\/VHRM.S569639","volume":"22","author":"H Wang","year":"2026","unstructured":"Wang, H., S. Wang, K. Fan, Y. Li, Z. Wang, M. Mawas, W. Chu, G. Musleh, and G. Zheng. 2026. Spatiotemporal Mortality Patterns and Temperature-Associated Risk of Aortic Dissection in the United States: A National CDC WONDER Database Analysis. Vascular Health And Risk Management 22:569639.","journal-title":"Vascular Health And Risk Management"},{"key":"2523_CR6","doi-asserted-by":"publisher","first-page":"2338","DOI":"10.1093\/eurjpc\/zwac205","volume":"29","author":"Y Suzuki","year":"2022","unstructured":"Suzuki, Y., H. Kaneko, Y. Yano, A. Okada, H. Itoh, K. Ueno, S. Matsuoka, K. Fujiu, N. Michihata, and T. Jo et al. 2022. Dose-dependent relationship of blood pressure and glycaemic status with risk of aortic dissection and aneurysm. Eur J Prev Cardiol 29:2338\u20132346.","journal-title":"Eur J Prev Cardiol"},{"key":"2523_CR7","doi-asserted-by":"publisher","first-page":"2516","DOI":"10.1161\/CIRCULATIONAHA.116.009762","volume":"133","author":"EM Isselbacher","year":"2016","unstructured":"Isselbacher, E. M., C. L. Lino Cardenas, and M. E. Lindsay. 2016. Hereditary Influence in Thoracic Aortic Aneurysm and Dissection. Circulation 133:2516\u20132528.","journal-title":"Circulation"},{"key":"2523_CR8","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1038\/s41569-020-00472-6","volume":"18","author":"E Bossone","year":"2021","unstructured":"Bossone, E., and K. A. Eagle. 2021. Epidemiology and management of aortic disease: aortic aneurysms and acute aortic syndromes. Nature Reviews. Cardiology 18:331\u2013348.","journal-title":"Nature Reviews. Cardiology"},{"key":"2523_CR9","doi-asserted-by":"publisher","first-page":"813","DOI":"10.1093\/eurheartj\/ehac757","volume":"44","author":"B Rylski","year":"2023","unstructured":"Rylski, B., O. Schilling, and M. Czerny. 2023. Acute aortic dissection: evidence, uncertainties, and future therapies. European Heart Journal 44:813\u2013821.","journal-title":"European Heart Journal"},{"key":"2523_CR10","doi-asserted-by":"publisher","first-page":"959","DOI":"10.1161\/CIRCULATIONAHA.123.063332","volume":"148","author":"A Chakraborty","year":"2023","unstructured":"Chakraborty, A., Y. Li, C. Zhang, Y. Li, K. R. Rebello, S. Li, S. Xu, H. G. Vasquez, L. Zhang, and W. Luo et al. 2023. Epigenetic Induction of Smooth Muscle Cell Phenotypic Alterations in Aortic Aneurysms and Dissections. Circulation 148:959\u2013977.","journal-title":"Circulation"},{"key":"2523_CR11","doi-asserted-by":"publisher","first-page":"101903","DOI":"10.1016\/j.redox.2021.101903","volume":"41","author":"P Gao","year":"2021","unstructured":"Gao, P., P. Gao, J. Zhao, S. Shan, W. Luo, O. J. Slivano, W. Zhang, A. Tabuchi, S. A. LeMaire, and L. Maegdefessel et al. 2021. MKL1 cooperates with p38MAPK to promote vascular senescence, inflammation, and abdominal aortic aneurysm. Redox Biology 41:101903.","journal-title":"Redox Biology"},{"key":"2523_CR12","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1007\/s00395-024-01053-1","volume":"119","author":"BH Ganizada","year":"2024","unstructured":"Ganizada, B. H., R. J. A. Veltrop, A. C. Akbulut, R. R. Koenen, R. Accord, R. Lorusso, J. G. Maessen, K. Reesink, E. Bidar, and L. J. Schurgers. 2024. Unveiling cellular and molecular aspects of ascending thoracic aortic aneurysms and dissections. Basic Research In Cardiology 119:371\u2013395.","journal-title":"Basic Research In Cardiology"},{"key":"2523_CR13","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s12276-019-0286-3","volume":"51","author":"S Jana","year":"2019","unstructured":"Jana, S., M. Hu, M. Shen, and Z. Kassiri. 2019. Extracellular matrix, regional heterogeneity of the aorta, and aortic aneurysm. Experimental & Molecular Medicine 51:1\u201315.","journal-title":"Experimental & Molecular Medicine"},{"key":"2523_CR14","doi-asserted-by":"publisher","first-page":"eaaz1173","DOI":"10.1126\/sciadv.aaz1173","volume":"6","author":"X Yu","year":"2020","unstructured":"Yu, X., B. Suki, and Y. Zhang. 2020. Avalanches and power law behavior in aortic dissection propagation. Science Advances 6:eaaz1173.","journal-title":"Science Advances"},{"key":"2523_CR15","doi-asserted-by":"publisher","first-page":"e2411152","DOI":"10.1002\/advs.202411152","volume":"12","author":"C Hu","year":"2025","unstructured":"Hu, C., H. Tan, Y. Zhang, G. Cao, C. Wu, P. Lin, S. Qiu, F. Mo, E. Wang, and S. Li et al. 2025. Fibroblast Activation Protein Acts as a Biomarker for Monitoring ECM Remodeling During Aortic Aneurysm via (68)Ga-FAPI-04 PET Imaging. Adv Sci (Weinh) 12:e2411152.","journal-title":"Adv Sci (Weinh)"},{"key":"2523_CR16","doi-asserted-by":"publisher","first-page":"1374","DOI":"10.1161\/CIRCULATIONAHA.120.046528","volume":"142","author":"Y Li","year":"2020","unstructured":"Li, Y., P. Ren, A. Dawson, H. G. Vasquez, W. Ageedi, C. Zhang, W. Luo, R. Chen, Y. Li, and S. Kim et al. 2020. Single-Cell Transcriptome Analysis Reveals Dynamic Cell Populations and Differential Gene Expression Patterns in Control and Aneurysmal Human Aortic Tissue. Circulation 142:1374\u20131388.","journal-title":"Circulation"},{"key":"2523_CR17","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1186\/s12964-023-01120-5","volume":"21","author":"G Cao","year":"2023","unstructured":"Cao, G., X. Xuan, Y. Li, J. Hu, R. Zhang, H. Jin, and H. Dong. 2023. Single-cell RNA sequencing reveals the vascular smooth muscle cell phenotypic landscape in aortic aneurysm. Cell Commun Signal 21:113.","journal-title":"Cell Commun Signal"},{"key":"2523_CR18","doi-asserted-by":"publisher","first-page":"1402","DOI":"10.1093\/cvr\/cvaa214","volume":"117","author":"G Zhao","year":"2021","unstructured":"Zhao, G., H. Lu, Z. Chang, Y. Zhao, T. Zhu, L. Chang, Y. Guo, M. T. Garcia-Barrio, Y. E. Chen, and J. Zhang. 2021. Single-cell RNA sequencing reveals the cellular heterogeneity of aneurysmal infrarenal abdominal aorta. Cardiovasc Res 117:1402\u20131416.","journal-title":"Cardiovasc Res"},{"key":"2523_CR19","doi-asserted-by":"publisher","first-page":"4373","DOI":"10.1093\/eurheartj\/ehab605","volume":"42","author":"H Cui","year":"2021","unstructured":"Cui, H., Y. Chen, K. Li, R. Zhan, M. Zhao, Y. Xu, Z. Lin, Y. Fu, Q. He, and P. C. Tang et al. 2021. Untargeted metabolomics identifies succinate as a biomarker and therapeutic target in aortic aneurysm and dissection. European Heart Journal 42:4373\u20134385.","journal-title":"European Heart Journal"},{"key":"2523_CR20","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1038\/s41421-021-00362-2","volume":"8","author":"X Liu","year":"2022","unstructured":"Liu, X., W. Chen, G. Zhu, H. Yang, W. Li, M. Luo, C. Shu, and Z. Zhou. 2022. Single-cell RNA sequencing identifies an Il1rn(+)\/Trem1(+) macrophage subpopulation as a cellular target for mitigating the progression of thoracic aortic aneurysm and dissection. Cell Discov 8:11.","journal-title":"Cell Discov"},{"key":"2523_CR21","doi-asserted-by":"publisher","first-page":"1351","DOI":"10.1093\/cvr\/cvae117","volume":"120","author":"S Le","year":"2024","unstructured":"Le, S., J. Wu, H. Liu, Y. Du, D. Wang, J. Luo, P. Yang, S. Ran, P. Hu, and M. Chen et al. 2024. Single-cell RNA sequencing identifies interferon-inducible monocytes\/macrophages as a cellular target for mitigating the progression of abdominal aortic aneurysm and rupture risk. Cardiovasc Res 120:1351\u20131364.","journal-title":"Cardiovasc Res"},{"key":"2523_CR22","doi-asserted-by":"publisher","first-page":"1986","DOI":"10.1161\/ATVBAHA.124.321129","volume":"44","author":"Z Yuan","year":"2024","unstructured":"Yuan, Z., L. Shu, J. Fu, P. Yang, Y. Wang, J. Sun, M. Zheng, Z. Liu, J. Yang, and J. Song et al. 2024. Single-Cell RNA Sequencing Deconstructs the Distribution of Immune Cells Within Abdominal Aortic Aneurysms in Mice. Arteriosclerosis, Thrombosis, And Vascular Biology 44:1986\u20132003.","journal-title":"Arteriosclerosis, Thrombosis, And Vascular Biology"},{"key":"2523_CR23","doi-asserted-by":"publisher","first-page":"342","DOI":"10.1016\/j.jacbts.2023.11.003","volume":"9","author":"N Ibrahim","year":"2024","unstructured":"Ibrahim, N., S. Bleichert, J. Klopf, G. Kurzreiter, H. Hayden, V. Kn\u00f6bl, T. Artner, M. Krall, A. Stiglbauer-Tscholakoff, and R. Oehler et al. 2024. Reducing Abdominal Aortic Aneurysm Progression by Blocking Neutrophil Extracellular Traps Depends on Thrombus Formation. JACC Basic Transl Sci 9:342\u2013360.","journal-title":"JACC Basic Transl Sci"},{"key":"2523_CR24","doi-asserted-by":"publisher","first-page":"10736","DOI":"10.1038\/s41467-024-55038-8","volume":"15","author":"YF Zhao","year":"2024","unstructured":"Zhao, Y. F., Z. A. Zuo, Z. Y. Li, Y. Yuan, S. C. Hong, W. G. Fu, B. Zhou, and L. X. Wang. 2024. Integrated multi-omics profiling reveals neutrophil extracellular traps potentiate Aortic dissection progression. Nature Communications 15:10736.","journal-title":"Nature Communications"},{"key":"2523_CR25","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1038\/s41420-024-02156-3","volume":"10","author":"H Wang","year":"2024","unstructured":"Wang, H., R. Zhang, X. Jia, S. Gao, T. Gao, K. Fan, Y. Li, S. Wang, M. Qiao, and S. Yan et al. 2024. Highly sensitive magnetic particle imaging of abdominal aortic aneurysm NETosis with anti-Ly6G iron oxide nanoparticles. Cell Death Discov 10:395.","journal-title":"Cell Death Discov"},{"key":"2523_CR26","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1161\/CIRCRESAHA.124.325458","volume":"136","author":"Y Wang","year":"2025","unstructured":"Wang, Y., X. Jia, Y. Zhang, B. Zhang, Y. Zhou, X. Li, X. Zhu, J. Xia, J. Ren, C. Zou, and Q. Zheng. 2025. ACKR1(hi)ECs Promote Aortic Dissection Through Adjusting Macrophage Behavior. Circ Res 136:211\u2013228.","journal-title":"Circ Res"},{"key":"2523_CR27","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1161\/CIRCRESAHA.125.326230","volume":"137","author":"K Kimura","year":"2025","unstructured":"Kimura, K., E. Motoyama, S. Kanki, K. Asano, P. Sips, M. A. A. Sheikh, M. Clarin, E. Raja, M. Takeda, and R. Ishii et al. 2025. Novel Aortic Dissection Model Links Endothelial Dysfunction and Immune Infiltration. Circ Res 137:26\u201342.","journal-title":"Circ Res"},{"key":"2523_CR28","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1038\/nbt.4096","volume":"36","author":"A Butler","year":"2018","unstructured":"Butler, A., P. Hoffman, P. Smibert, E. Papalexi, and R. Satija. 2018. Integrating single-cell transcriptomic data across different conditions, technologies, and species. Nature Biotechnology 36:411\u2013420.","journal-title":"Nature Biotechnology"},{"key":"2523_CR29","doi-asserted-by":"publisher","first-page":"511","DOI":"10.1097\/SLA.0000000000005551","volume":"276","author":"FM Davis","year":"2022","unstructured":"Davis, F. M., L. C. Tsoi, F. Ma, R. Wasikowski, B. B. Moore, S. L. Kunkel, J. E. Gudjonsson, and K. A. Gallagher. 2022. Single-cell Transcriptomics Reveals Dynamic Role of Smooth Muscle Cells and Enrichment of Immune Cell Subsets in Human Abdominal Aortic Aneurysms. Annals Of Surgery 276:511\u2013521.","journal-title":"Annals Of Surgery"},{"key":"2523_CR30","doi-asserted-by":"publisher","first-page":"542","DOI":"10.1016\/j.stem.2020.02.013","volume":"26","author":"PY Chen","year":"2020","unstructured":"Chen, P. Y., L. Qin, G. Li, J. Malagon-Lopez, Z. Wang, S. Bergaya, S. Gujja, A. W. Caulk, S. I. Murtada, and X. Zhang et al. 2020. Smooth Muscle Cell Reprogramming in Aortic Aneurysms. Cell Stem Cell 26:542\u2013557e511.","journal-title":"Cell Stem Cell"},{"key":"2523_CR31","doi-asserted-by":"publisher","first-page":"2693","DOI":"10.1161\/ATVBAHA.121.316600","volume":"41","author":"C Yap","year":"2021","unstructured":"Yap, C., A. Mieremet, C. J. M. de Vries, D. Micha, and V. de Waard. 2021. Six Shades of Vascular Smooth Muscle Cells Illuminated by KLF4 (Kr\u00fcppel-Like Factor 4). Arteriosclerosis, Thrombosis, And Vascular Biology 41:2693\u20132707.","journal-title":"Arteriosclerosis, Thrombosis, And Vascular Biology"},{"key":"2523_CR32","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1038\/nbt.2859","volume":"32","author":"C Trapnell","year":"2014","unstructured":"Trapnell, C., D. Cacchiarelli, J. Grimsby, P. Pokharel, S. Li, M. Morse, N. J. Lennon, K. J. Livak, T. S. Mikkelsen, and J. L. Rinn. 2014. The dynamics and regulators of cell fate decisions are revealed by pseudotemporal ordering of single cells. Nature Biotechnology 32:381\u2013386.","journal-title":"Nature Biotechnology"},{"key":"2523_CR33","doi-asserted-by":"publisher","first-page":"1088","DOI":"10.1038\/s41467-021-21246-9","volume":"12","author":"S Jin","year":"2021","unstructured":"Jin, S., C. F. Guerrero-Juarez, L. Zhang, I. Chang, R. Ramos, C. H. Kuan, P. Myung, M. V. Plikus, and Q. Nie. 2021. Inference and analysis of cell-cell communication using CellChat. Nature Communications 12:1088.","journal-title":"Nature Communications"},{"key":"2523_CR34","doi-asserted-by":"publisher","first-page":"e70328","DOI":"10.1111\/jcmm.70328","volume":"29","author":"X Xuan","year":"2025","unstructured":"Xuan, X., Y. Li, G. Cao, J. Hu, S. Yan, H. Jin, M. Qiao, R. Zhang, and H. Dong. 2025. Inhibition of Abdominal Aortic Aneurysm Progression Through the CXCL12\/CXCR4 Axis via MiR206-3p Sponge. Journal Of Cellular And Molecular Medicine 29:e70328.","journal-title":"Journal Of Cellular And Molecular Medicine"},{"key":"2523_CR35","doi-asserted-by":"publisher","first-page":"1555","DOI":"10.1161\/ATVBAHA.123.320402","volume":"44","author":"MK Franklin","year":"2024","unstructured":"Franklin, M. K., H. Sawada, S. Ito, D. A. Howatt, N. Amioka, C. L. Liang, N. Zhang, D. B. Graf, J. J. Moorleghen, and Y. Katsumata et al. 2024. \u03b2-Aminopropionitrile Induces Distinct Pathologies in the Ascending and Descending Thoracic Aortic Regions of Mice. Arteriosclerosis, Thrombosis, And Vascular Biology 44:1555\u20131569.","journal-title":"Arteriosclerosis, Thrombosis, And Vascular Biology"},{"key":"2523_CR36","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1186\/s12964-022-00993-2","volume":"20","author":"G Cao","year":"2022","unstructured":"Cao, G., X. Xuan, J. Hu, R. Zhang, H. Jin, and H. Dong. 2022. How vascular smooth muscle cell phenotype switching contributes to vascular disease. Cell Commun Signal 20:180.","journal-title":"Cell Commun Signal"},{"key":"2523_CR37","doi-asserted-by":"crossref","unstructured":"Xing, M., W. Chen, Y. Ji, and W. Song. 2024. SLC44A2-mediated phenotypic switch of vascular smooth muscle cells contributes to aortic aneurysm. The Journal of Clinical Investigation 134.","DOI":"10.1172\/JCI183527"},{"key":"2523_CR38","doi-asserted-by":"publisher","first-page":"e14237","DOI":"10.1111\/apha.14237","volume":"240","author":"X Han","year":"2024","unstructured":"Han, X., S. Xu, K. Hu, Y. Yu, X. Wang, C. Qu, B. Yang, and X. Liu. 2024. Early growth response 1 exacerbates thoracic aortic aneurysm and dissection of mice by inducing the phenotypic switching of vascular smooth muscle cell through the activation of Kr\u00fcppel-like factor 5. Acta Physiol (Oxf) 240:e14237.","journal-title":"Acta Physiol (Oxf)"},{"key":"2523_CR39","doi-asserted-by":"crossref","unstructured":"Song, T., S. Zhao, S. Luo, C. Chen, X. Liu, X. Wu, Z. Sun, J. Cao, Z. Wang, and Y. Wang et al. 2024. SLC44A2 regulates vascular smooth muscle cell phenotypic switching and aortic aneurysm. The Journal of Clinical Investigation 134.","DOI":"10.1172\/JCI173690"},{"key":"2523_CR40","doi-asserted-by":"publisher","first-page":"234","DOI":"10.1161\/ATVBAHA.122.318135","volume":"43","author":"C Zhang","year":"2023","unstructured":"Zhang, C., Y. Li, A. Chakraborty, Y. Li, K. R. Rebello, P. Ren, W. Luo, L. Zhang, H. S. Lu, and L. A. Cassis et al. 2023. Aortic Stress Activates an Adaptive Program in Thoracic Aortic Smooth Muscle Cells That Maintains Aortic Strength and Protects Against Aneurysm and Dissection in Mice. Arteriosclerosis, Thrombosis, And Vascular Biology 43:234\u2013252.","journal-title":"Arteriosclerosis, Thrombosis, And Vascular Biology"},{"key":"2523_CR41","doi-asserted-by":"publisher","first-page":"1081","DOI":"10.1093\/cvr\/cvae081","volume":"120","author":"H Liu","year":"2024","unstructured":"Liu, H., P. Yang, S. Chen, S. Wang, L. Jiang, X. Xiao, S. Le, S. Chen, X. Chen, P. Ye, and J. Xia. 2024. Ncf1 knockout in smooth muscle cells exacerbates angiotensin II-induced aortic aneurysm and dissection by activating the STING pathway. Cardiovasc Res 120:1081\u20131096.","journal-title":"Cardiovasc Res"},{"key":"2523_CR42","doi-asserted-by":"publisher","first-page":"1903","DOI":"10.1161\/CIRCULATIONAHA.123.066404","volume":"149","author":"Y Zhang","year":"2024","unstructured":"Zhang, Y., H. Zhang, S. Zhao, Z. Qi, Y. He, X. Zhang, W. Wu, K. Yan, L. Hu, and S. Sun et al. 2024. S-Nitrosylation of Septin2 Exacerbates Aortic Aneurysm and Dissection by Coupling the TIAM1-RAC1 Axis in Macrophages. Circulation 149:1903\u20131920.","journal-title":"Circulation"},{"key":"2523_CR43","doi-asserted-by":"publisher","first-page":"1382","DOI":"10.1161\/CIRCULATIONAHA.122.062743","volume":"147","author":"S Luo","year":"2023","unstructured":"Luo, S., C. Kong, S. Zhao, X. Tang, Y. Wang, X. Zhou, R. Li, X. Liu, X. Tang, and S. Sun et al. 2023. Endothelial HDAC1-ZEB2-NuRD Complex Drives Aortic Aneurysm and Dissection Through Regulation of Protein S-Sulfhydration. Circulation 147:1382\u20131403.","journal-title":"Circulation"},{"key":"2523_CR44","doi-asserted-by":"publisher","first-page":"5985","DOI":"10.1038\/s41467-024-50036-2","volume":"15","author":"ZL Liu","year":"2024","unstructured":"Liu, Z. L., Y. Li, Y. J. Lin, M. M. Shi, M. X. Fu, Z. Q. Li, D. S. Ning, X. M. Zeng, X. Liu, and Q. H. Cui et al. 2024. Aging aggravates aortic aneurysm and dissection via miR-1204-MYLK signaling axis in mice. Nature Communications 15:5985.","journal-title":"Nature Communications"},{"key":"2523_CR45","doi-asserted-by":"publisher","first-page":"102257","DOI":"10.1016\/j.redox.2022.102257","volume":"50","author":"G Dang","year":"2022","unstructured":"Dang, G., T. Li, D. Yang, G. Yang, X. Du, J. Yang, Y. Miao, L. Han, X. Ma, and Y. Song et al. 2022. T lymphocyte-derived extracellular vesicles aggravate abdominal aortic aneurysm by promoting macrophage lipid peroxidation and migration via pyruvate kinase muscle isozyme 2. Redox Biology 50:102257.","journal-title":"Redox Biology"},{"key":"2523_CR46","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1002\/bjs.1800830122","volume":"83","author":"S Svensj\u00f6","year":"1996","unstructured":"Svensj\u00f6, S., H. Bengtsson, and D. Bergqvist. 1996. Thoracic and thoracoabdominal aortic aneurysm and dissection: an investigation based on autopsy. British Journal Of Surgery 83:68\u201371.","journal-title":"British Journal Of Surgery"},{"key":"2523_CR47","doi-asserted-by":"crossref","unstructured":"Lu, H. S., H. Sawada, and C. Wu. 2022. Aortic Aneurysm and Dissection: Heterogeneity and Molecular Mechanisms. Biomolecules 12.","DOI":"10.3390\/biom12101536"},{"key":"2523_CR48","doi-asserted-by":"publisher","first-page":"756","DOI":"10.1001\/jama.2023.0265","volume":"329","author":"I Hameed","year":"2023","unstructured":"Hameed, I., A. S. Cifu, and P. Vallabhajosyula. 2023. Management of Thoracic Aortic Dissection. Jama 329:756\u2013757.","journal-title":"Jama"},{"key":"2523_CR49","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1038\/s41392-023-01325-7","volume":"8","author":"J Gao","year":"2023","unstructured":"Gao, J., H. Cao, G. Hu, Y. Wu, Y. Xu, H. Cui, H. S. Lu, and L. Zheng. 2023. The mechanism and therapy of aortic aneurysms. Signal Transduct Target Ther 8:55.","journal-title":"Signal Transduct Target Ther"},{"key":"2523_CR50","doi-asserted-by":"publisher","first-page":"730","DOI":"10.1148\/radiol.221044","volume":"304","author":"H Sakuma","year":"2022","unstructured":"Sakuma, H. 2022. Abdominal Aortic Aneurysm: Prediction of Rupture Risk with MR Elastography. Radiology 304:730\u2013731.","journal-title":"Radiology"},{"key":"2523_CR51","doi-asserted-by":"publisher","first-page":"1248","DOI":"10.1093\/eurheartj\/ehac823","volume":"44","author":"X Yang","year":"2023","unstructured":"Yang, X., C. Xu, F. Yao, Q. Ding, H. Liu, C. Luo, D. Wang, J. Huang, Z. Li, and Y. Shen et al. 2023. Targeting endothelial tight junctions to predict and protect thoracic aortic aneurysm and dissection. European Heart Journal 44:1248\u20131261.","journal-title":"European Heart Journal"},{"key":"2523_CR52","doi-asserted-by":"publisher","first-page":"1510","DOI":"10.1093\/cvr\/cvaa234","volume":"117","author":"E Roy-Chowdhury","year":"2021","unstructured":"Roy-Chowdhury, E., N. Brauns, A. Helmke, J. Nordlohne, J. H. Br\u00e4sen, J. Schmitz, J. Volkmann, S. V. Fleig, K. Kusche-Vihrog, H. Haller, and S. von Vietinghoff. 2021. Human CD16\u2009+\u2009monocytes promote a pro-atherosclerotic endothelial cell phenotype via CX3CR1-CX3CL1 interaction. Cardiovasc Res 117:1510\u20131522.","journal-title":"Cardiovasc Res"},{"key":"2523_CR53","doi-asserted-by":"publisher","first-page":"9101","DOI":"10.1038\/s41467-024-53307-0","volume":"15","author":"X Xie","year":"2024","unstructured":"Xie, X., P. Wang, M. Jin, Y. Wang, L. Qi, C. Wu, S. Guo, C. Li, X. Zhang, and Y. Yuan et al. 2024. IL-1\u03b2-induced epithelial cell and fibroblast transdifferentiation promotes neutrophil recruitment in chronic rhinosinusitis with nasal polyps. Nature Communications 15:9101.","journal-title":"Nature Communications"},{"key":"2523_CR54","doi-asserted-by":"publisher","first-page":"833","DOI":"10.1016\/j.immuni.2016.01.012","volume":"44","author":"MM Gaidt","year":"2016","unstructured":"Gaidt, M. M., T. S. Ebert, D. Chauhan, T. Schmidt, J. L. Schmid-Burgk, F. Rapino, A. A. Robertson, M. A. Cooper, T. Graf, and V. Hornung. 2016. Human Monocytes Engage an Alternative Inflammasome Pathway. Immunity 44:833\u2013846.","journal-title":"Immunity"},{"key":"2523_CR55","doi-asserted-by":"publisher","first-page":"1102","DOI":"10.1038\/s41401-020-0374-x","volume":"41","author":"XM Wei","year":"2020","unstructured":"Wei, X. M., G. Wumaier, N. Zhu, L. Dong, C. W. Li, J. W. Xia, Y. Z. Zhang, P. Zhang, X. J. Zhang, Y. Y. Zhang, and S. Q. Li. 2020. Protein tyrosine phosphatase L1 represses endothelial-mesenchymal transition by inhibiting IL-1\u03b2\/NF-\u03baB\/Snail signaling. Acta Pharmacologica Sinica 41:1102\u20131110.","journal-title":"Acta Pharmacologica Sinica"},{"key":"2523_CR56","doi-asserted-by":"publisher","first-page":"1323","DOI":"10.1007\/s00109-023-02370-z","volume":"101","author":"D Freiholtz","year":"2023","unstructured":"Freiholtz, D., O. Bergman, S. Pradhananga, K. L\u00e5ng, F. A. Poujade, C. Granath, C. Olsson, A. Franco-Cereceda, P. Sahl\u00e9n, P. Eriksson, and H. M. Bj\u00f6rck. 2023. SPP1\/osteopontin: a driver of fibrosis and inflammation in degenerative ascending aortic aneurysm? J Mol Med (Berl) 101:1323\u20131333.","journal-title":"J Mol Med (Berl)"},{"key":"2523_CR57","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1093\/cvr\/cvad168","volume":"120","author":"MU Wagenh\u00e4user","year":"2024","unstructured":"Wagenh\u00e4user, M. U., J. Mulorz, K. J. Krott, A. Bosbach, T. Feige, Y. H. Rhee, M. Chatterjee, N. Petzold, C. B\u00f6ddeker, and W. Ibing et al. 2024. Crosstalk of platelets with macrophages and fibroblasts aggravates inflammation, aortic wall stiffening, and osteopontin release in abdominal aortic aneurysm. Cardiovasc Res 120:417\u2013432.","journal-title":"Cardiovasc Res"},{"key":"2523_CR58","doi-asserted-by":"publisher","first-page":"1318","DOI":"10.1172\/JCI200318141","volume":"112","author":"D Bruemmer","year":"2003","unstructured":"Bruemmer, D., A. R. Collins, G. Noh, W. Wang, M. Territo, S. Arias-Magallona, M. C. Fishbein, F. Blaschke, U. Kintscher, and K. Graf et al. 2003. Angiotensin II-accelerated atherosclerosis and aneurysm formation is attenuated in osteopontin-deficient mice. J Clin Invest 112:1318\u20131331.","journal-title":"J Clin Invest"}],"container-title":["Inflammation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10753-026-02523-5","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10753-026-02523-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10753-026-02523-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T17:03:40Z","timestamp":1783357420000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10753-026-02523-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,12]]},"references-count":58,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["2523"],"URL":"https:\/\/doi.org\/10.1007\/s10753-026-02523-5","relation":{},"ISSN":["1573-2576"],"issn-type":[{"value":"1573-2576","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,12]]},"assertion":[{"value":"29 June 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 March 2026","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 May 2026","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 May 2026","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All animal procedures were approved by the Ethics Committee of the Second Hospital of Shanxi Medical University (Approval No. 2024005).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics Approval and Consent to Participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for Publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"159"}}