{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T19:26:54Z","timestamp":1792783614757,"version":"4.5.0"},"reference-count":33,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T00:00:00Z","timestamp":1779148800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T00:00:00Z","timestamp":1783900800000},"content-version":"vor","delay-in-days":55,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"Science and Technology Fund of Tianjin Municipal Education Commission","award":["2021KJ216"],"award-info":[{"award-number":["2021KJ216"]}],"id":[{"id":"https:\/\/ror.org\/01z7y3r39","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Key Laboratory of Medical Rescue Key Technology and Equipment, Ministry of Emergency Management","award":["Open Fund Project No.YJBKFKT202419"],"award-info":[{"award-number":["Open Fund Project No.YJBKFKT202419"]}],"id":[{"id":"https:\/\/ror.org\/02e6b1s72","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Inflammation"],"DOI":"10.1007\/s10753-026-02526-2","type":"journal-article","created":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T11:57:03Z","timestamp":1779191823000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Inhibition of MyD88 in Tubular Epithelial Cells Alleviates the Cellular Senescence in Sepsis-Associated Acute Kidney Injury"],"prefix":"10.1007","volume":"49","author":[{"given":"Yan","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yali","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingxin","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Congcong","family":"Yao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuxin","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keke","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massimo","family":"Attanasio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Songtao","family":"Shou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heng","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,5,19]]},"reference":[{"issue":"1","key":"2526_CR1","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1186\/s13054-025-05351-5","volume":"29","author":"T Takeuchi","year":"2025","unstructured":"Takeuchi, T., A. H. Flannery, L. J. Liu, L. Ghazi, A. Cama-Olivares, and K. Fushimi et al. 2025. Epidemiology of sepsis-associated acute kidney injury in the ICU with contemporary consensus definitions. Critical Care 29(1):128. https:\/\/doi.org\/10.1186\/s13054-025-05351-5","journal-title":"Critical Care"},{"issue":"1","key":"2526_CR2","doi-asserted-by":"publisher","first-page":"2441393","DOI":"10.1080\/0886022X.2024.2441393","volume":"47","author":"B Shi","year":"2025","unstructured":"Shi, B., J. Ye, W. Chen, B. Liao, W. Gu, H. Yin, and J. Lyu. 2025. Prognosis of critically ill patients with early and late sepsis-associated acute kidney injury: an observational study based on the MIMIC-IV. Renal Failure 47(1):2441393. https:\/\/doi.org\/10.1080\/0886022X.2024.2441393","journal-title":"Renal Failure"},{"issue":"6","key":"2526_CR3","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1038\/s41581-023-00683-3","volume":"19","author":"A Zarbock","year":"2023","unstructured":"Zarbock, A., M. K. Nadim, P. Pickkers, H. Gomez, S. Bell, and M. Joannidis et al. 2023. Sepsis-associated acute kidney injury: consensus report of the 28th Acute Disease Quality Initiative workgroup. Nature Reviews Nephrology 19(6):401\u2013417. https:\/\/doi.org\/10.1038\/s41581-023-00683-3","journal-title":"Nature Reviews Nephrology"},{"key":"2526_CR4","doi-asserted-by":"publisher","unstructured":"Pais, T., S. Jorge, and J. A. Lopes. 2024. Acute Kidney Injury in Sepsis. International Journal Of Molecular Sciences 25(11). https:\/\/doi.org\/10.3390\/ijms25115924","DOI":"10.3390\/ijms25115924"},{"issue":"28","key":"2526_CR5","doi-asserted-by":"publisher","first-page":"e2307216","DOI":"10.1002\/advs.202307216","volume":"11","author":"J Qiao","year":"2024","unstructured":"Qiao, J., Y. Tan, H. Liu, B. Yang, Q. Zhang, and Q. Liu et al. 2024. Histone H3K18 and Ezrin Lactylation Promote Renal Dysfunction in Sepsis-Associated Acute Kidney Injury. Adv Sci (Weinh) 11(28):e2307216. https:\/\/doi.org\/10.1002\/advs.202307216","journal-title":"Adv Sci (Weinh)"},{"issue":"1","key":"2526_CR6","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1186\/s13148-025-01861-9","volume":"17","author":"Y Yang","year":"2025","unstructured":"Yang, Y., X. Deng, W. Li, Y. Leng, Y. Xiong, and B. Wang et al. 2025. Targeting the epigenetic regulation of ferroptosis: a potential therapeutic approach for sepsis-associated acute kidney injury. Clin Epigenetics 17(1):57. https:\/\/doi.org\/10.1186\/s13148-025-01861-9","journal-title":"Clin Epigenetics"},{"issue":"49","key":"2526_CR7","doi-asserted-by":"publisher","first-page":"31535","DOI":"10.1073\/pnas.1920338117","volume":"117","author":"S An","year":"2020","unstructured":"An, S., S. Y. Cho, J. Kang, S. Lee, H. S. Kim, and D. J. Min et al. 2020. Inhibition of 3-phosphoinositide-dependent protein kinase 1 (PDK1) can revert cellular senescence in human dermal fibroblasts. Proc Natl Acad Sci U S A 117(49):31535\u201331546. https:\/\/doi.org\/10.1073\/pnas.1920338117","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"8","key":"2526_CR8","doi-asserted-by":"publisher","first-page":"2043","DOI":"10.1016\/j.cell.2025.03.011","volume":"188","author":"G Kroemer","year":"2025","unstructured":"Kroemer, G., A. B. Maier, A. M. Cuervo, V. N. Gladyshev, L. Ferrucci, and V. Gorbunova et al. 2025. From geroscience to precision geromedicine: Understanding and managing aging. Cell 188(8):2043\u20132062. https:\/\/doi.org\/10.1016\/j.cell.2025.03.011","journal-title":"Cell"},{"issue":"12","key":"2526_CR9","doi-asserted-by":"publisher","first-page":"1001","DOI":"10.1038\/s41580-024-00738-8","volume":"25","author":"V Suryadevara","year":"2024","unstructured":"Suryadevara, V., A. D. Hudgins, A. Rajesh, A. Pappalardo, A. Karpova, and A. K. Dey et al. 2024. SenNet recommendations for detecting senescent cells in different tissues. Nature Reviews Molecular Cell Biology 25(12):1001\u20131023. https:\/\/doi.org\/10.1038\/s41580-024-00738-8","journal-title":"Nature Reviews Molecular Cell Biology"},{"issue":"2","key":"2526_CR10","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1038\/s43587-023-00564-1","volume":"4","author":"X Hao","year":"2024","unstructured":"Hao, X., B. Zhao, M. Towers, L. Liao, E. L. Monteiro, and X. Xu et al. 2024. TXNRD1 drives the innate immune response in senescent cells with implications for age-associated inflammation. Nat Aging 4(2):185\u2013197. https:\/\/doi.org\/10.1038\/s43587-023-00564-1","journal-title":"Nat Aging"},{"issue":"1","key":"2526_CR11","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1038\/s41569-022-00739-0","volume":"20","author":"SI Bloom","year":"2023","unstructured":"Bloom, S. I., M. T. Islam, L. A. Lesniewski, and A. J. Donato. 2023. Mechanisms and consequences of endothelial cell senescence. Nature Reviews. Cardiology 20(1):38\u201351. https:\/\/doi.org\/10.1038\/s41569-022-00739-0","journal-title":"Nature Reviews. Cardiology"},{"key":"2526_CR12","doi-asserted-by":"publisher","unstructured":"Xu, J., L. Kang, B. Tai, C. Liu, Z. Zhang, and Q. Ding et al. 2025. The stems of Syringa oblata Lindl. exert cardioprotective effects against acute myocardial ischemia by inhibiting the TLR4\/MyD88\/NF-kappaB and NLRP3 inflammasome signaling pathways in mice. Journal Of Ethnopharmacology 344119563. https:\/\/doi.org\/10.1016\/j.jep.2025.119563","DOI":"10.1016\/j.jep.2025.119563"},{"issue":"5","key":"2526_CR13","doi-asserted-by":"publisher","first-page":"937","DOI":"10.4103\/1319-2442.301200","volume":"31","author":"P Zhang","year":"2020","unstructured":"Zhang, P., H. Peng, C. Gao, Z. Fan, and Z. Xia. 2020. Aspirin-Triggered Lipoxin Protects Lipopolysaccharide-Induced Acute Kidney Injury via the TLR4\/MyD88\/NF-kappaB Pathway. Saudi J Kidney Dis Transpl 31(5):937\u2013945. https:\/\/doi.org\/10.4103\/1319-2442.301200","journal-title":"Saudi J Kidney Dis Transpl"},{"issue":"3","key":"2526_CR14","doi-asserted-by":"publisher","first-page":"106599","DOI":"10.1016\/j.jinf.2025.106599","volume":"91","author":"W Bauer","year":"2025","unstructured":"Bauer, W., N. Galtung, P. Geserick, K. Friedrich, M. Weber, and R. Somasundaram et al. 2025. Pentraxin-3, MyD88, GLP-1, and PD-L1: Performance assessment and composite algorithmic analysis for sepsis identification. Journal Of Infection 91(3):106599. https:\/\/doi.org\/10.1016\/j.jinf.2025.106599","journal-title":"Journal Of Infection"},{"key":"2526_CR15","doi-asserted-by":"publisher","unstructured":"Jin, H., Y. Zhang, Q. Ding, S. S. Wang, P. Rastogi, and D. F. Dai et al. 2019. Epithelial innate immunity mediates tubular cell senescence after kidney injury. JCI Insight 4(2). https:\/\/doi.org\/10.1172\/jci.insight.125490","DOI":"10.1172\/jci.insight.125490"},{"key":"2526_CR16","doi-asserted-by":"publisher","first-page":"112058","DOI":"10.1016\/j.mad.2025.112058","volume":"225","author":"K Lin","year":"2025","unstructured":"Lin, K., X. Luo, C. Du, C. Zuo, Z. Li, and G. Zhang et al. 2025. ANRIL modulates endothelial senescence and angiogenesis through SASP-driven miR146a regulation in age-related vascular dysfunction. Mechanisms Of Ageing And Development 225:112058. https:\/\/doi.org\/10.1016\/j.mad.2025.112058","journal-title":"Mechanisms Of Ageing And Development"},{"issue":"10","key":"2526_CR17","doi-asserted-by":"publisher","first-page":"e14258","DOI":"10.1111\/acel.14258","volume":"23","author":"F Herbstein","year":"2024","unstructured":"Herbstein, F., M. Sapochnik, A. Attorresi, C. Pollak, S. Senin, and D. Gonilski-Pacin et al. 2024. The SASP factor IL-6 sustains cell-autonomous senescent cells via a cGAS-STING-NFkappaB intracrine senescent noncanonical pathway. Aging Cell 23(10):e14258. https:\/\/doi.org\/10.1111\/acel.14258","journal-title":"Aging Cell"},{"issue":"Pt A","key":"2526_CR18","doi-asserted-by":"publisher","first-page":"120310","DOI":"10.1016\/j.jep.2025.120310","volume":"353","author":"Y Zhao","year":"2025","unstructured":"Zhao, Y., M. Zhang, L. Dong, Q. Zhang, J. Bai, and Y. Hao et al. 2025. Effects of and mechanisms underlying qingwen baidu decoction in sepsis-associated acute kidney injury. Journal Of Ethnopharmacology 353(Pt A):120310. https:\/\/doi.org\/10.1016\/j.jep.2025.120310","journal-title":"Journal Of Ethnopharmacology"},{"issue":"4","key":"2526_CR19","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1038\/s41419-022-04794-w","volume":"13","author":"B Wang","year":"2022","unstructured":"Wang, B., J. Xu, Q. Ren, L. Cheng, F. Guo, and Y. Liang et al. 2022. Fatty acid-binding protein 4 is a therapeutic target for septic acute kidney injury by regulating inflammatory response and cell apoptosis. Cell Death And Disease 13(4):333. https:\/\/doi.org\/10.1038\/s41419-022-04794-w","journal-title":"Cell Death And Disease"},{"key":"2526_CR20","doi-asserted-by":"publisher","unstructured":"Chen, P., K. Dong, L. Zhu, N. Huang, K. Zhang, and Y. Lv et al. Discovery of 3\u00a0g as an Orally Bioavailable, TIR Domain Selective, and Potent MyD88 Inhibitor for the Treatment of Acute Lung Injury. J Med Chem 2025https:\/\/doi.org\/10.1021\/acs.jmedchem.5c01786","DOI":"10.1021\/acs.jmedchem.5c01786"},{"issue":"4","key":"2526_CR21","doi-asserted-by":"publisher","first-page":"769","DOI":"10.1016\/j.kint.2023.07.006","volume":"104","author":"C Yuan","year":"2023","unstructured":"Yuan, C., G. Jin, P. Li, W. Wang, C. Ge, and Y. Pan et al. 2023. Tubular cell transcriptional intermediary factor 1gamma deficiency exacerbates kidney injury-induced tubular cell polyploidy and fibrosis. Kidney International 104(4):769\u2013786. https:\/\/doi.org\/10.1016\/j.kint.2023.07.006","journal-title":"Kidney International"},{"issue":"1","key":"2526_CR22","doi-asserted-by":"publisher","first-page":"20220700","DOI":"10.1515\/biol-2022-0700","volume":"18","author":"W Wei","year":"2023","unstructured":"Wei, W., Y. Zhao, Y. Zhang, S. Shou, and H. Jin. 2023. The early diagnosis and pathogenic mechanisms of sepsis-related acute kidney injury. Open Life Sci 18(1):20220700. https:\/\/doi.org\/10.1515\/biol-2022-0700","journal-title":"Open Life Sci"},{"issue":"1","key":"2526_CR23","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1186\/s13613-016-0157-1","volume":"6","author":"CJ Luo","year":"2016","unstructured":"Luo, C. J., F. Luo, L. Zhang, Y. Xu, G. Y. Cai, and B. Fu et al. 2016. Knockout of interleukin-17A protects against sepsis-associated acute kidney injury. Ann Intensive Care 6(1):56. https:\/\/doi.org\/10.1186\/s13613-016-0157-1","journal-title":"Ann Intensive Care"},{"key":"2526_CR24","doi-asserted-by":"publisher","unstructured":"Dong, Y., G. Liu, X. Situ, L. Xia, T. Zhang, and X. Zhu et al. Non-Canonical STING-PERK Pathway Modulation of Cellular Senescence and Therapeutic Response in Sepsis-Associated Acute Kidney Injury. Inflammation 2024https:\/\/doi.org\/10.1007\/s10753-024-02081-8","DOI":"10.1007\/s10753-024-02081-8"},{"issue":"12","key":"2526_CR25","doi-asserted-by":"publisher","first-page":"3009","DOI":"10.1007\/s00467-022-05532-2","volume":"37","author":"X Lin","year":"2022","unstructured":"Lin, X., H. Jin, Y. Chai, and S. Shou. 2022. Cellular senescence and acute kidney injury. Pediatric Nephrology(Berlin, Germany) 37(12):3009\u20133018. https:\/\/doi.org\/10.1007\/s00467-022-05532-2","journal-title":"Pediatric Nephrology(Berlin, Germany)"},{"key":"2526_CR26","doi-asserted-by":"publisher","first-page":"4449","DOI":"10.2147\/DDDT.S480148","volume":"18","author":"J Wang","year":"2024","unstructured":"Wang, J., Y. Wu, M. Mao, H. Bing, L. Sun, and W. Xu et al. 2024. Sivelestat Sodium Alleviates Ischemia-Reperfusion-Induced Acute Kidney Injury via Suppressing TLR4\/Myd88\/NF-kappaB Signaling Pathway in Mice. Drug Design, Development And Therapy 18:4449\u20134458. https:\/\/doi.org\/10.2147\/DDDT.S480148","journal-title":"Drug Design, Development And Therapy"},{"key":"2526_CR27","doi-asserted-by":"publisher","first-page":"108541","DOI":"10.1016\/j.intimp.2022.108541","volume":"105","author":"W Zhou","year":"2022","unstructured":"Zhou, W., S. Peng, P. Du, P. Zhou, C. Xue, and Q. Ye. 2022. Hypothermic oxygenated perfusion combined with TJ-M2010-5 alleviates hepatic ischemia-reperfusion injury in donation after circulatory death. International Immunopharmacology 105:108541. https:\/\/doi.org\/10.1016\/j.intimp.2022.108541","journal-title":"International Immunopharmacology"},{"issue":"3","key":"2526_CR28","doi-asserted-by":"publisher","first-page":"167703","DOI":"10.1016\/j.bbadis.2025.167703","volume":"1871","author":"P Umbarkar","year":"2025","unstructured":"Umbarkar, P., S. Tousif, A. Jaiswal, A. S. Bhati, A. Toro Cora, and R. Sethi et al. 2025. Fibroblast-specific MyD88-dependent signaling aggravates inflammation and cardiac dysfunction in the MI heart. Biochim Biophys Acta Mol Basis Dis 1871(3):167703. https:\/\/doi.org\/10.1016\/j.bbadis.2025.167703","journal-title":"Biochim Biophys Acta Mol Basis Dis"},{"issue":"1","key":"2526_CR29","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1016\/j.ajpath.2019.09.013","volume":"190","author":"H Jin","year":"2020","unstructured":"Jin, H., Y. Zhang, D. Liu, S. S. Wang, Q. Ding, and P. Rastogi et al. 2020. Innate Immune Signaling Contributes to Tubular Cell Senescence in the Glis2 Knockout Mouse Model of Nephronophthisis. American Journal Of Pathology 190(1):176\u2013189. https:\/\/doi.org\/10.1016\/j.ajpath.2019.09.013","journal-title":"American Journal Of Pathology"},{"issue":"1","key":"2526_CR30","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1038\/s41420-024-01831-9","volume":"10","author":"J Chen","year":"2024","unstructured":"Chen, J., H. Zhang, X. Yi, Q. Dou, X. Yang, and Y. He et al. 2024. Cellular senescence of renal tubular epithelial cells in acute kidney injury. Cell Death Discov 10(1):62. https:\/\/doi.org\/10.1038\/s41420-024-01831-9","journal-title":"Cell Death Discov"},{"issue":"1","key":"2526_CR31","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1186\/s40635-024-00594-y","volume":"12","author":"T Miura","year":"2024","unstructured":"Miura, T., T. Okuda, K. Suzuki, H. Okada, H. Tomita, and C. Takada et al. 2024. Recombinant antithrombin attenuates acute kidney injury associated with rhabdomyolysis: an in vivo animal study. Intensive Care Med Exp 12(1):7. https:\/\/doi.org\/10.1186\/s40635-024-00594-y","journal-title":"Intensive Care Med Exp"},{"issue":"1","key":"2526_CR32","doi-asserted-by":"publisher","first-page":"226","DOI":"10.1038\/s41419-025-07526-y","volume":"16","author":"X Yang","year":"2025","unstructured":"Yang, X., Y. Guan, G. Bayliss, T. C. Zhao, and S. Zhuang. 2025. SET8 inhibition preserves PTEN to attenuate kidney cell apoptosis in cisplatin nephrotoxicity. Cell Death And Disease 16(1):226. https:\/\/doi.org\/10.1038\/s41419-025-07526-y","journal-title":"Cell Death And Disease"},{"issue":"2","key":"2526_CR33","doi-asserted-by":"publisher","first-page":"354","DOI":"10.1038\/s41401-021-00766-6","volume":"43","author":"QY Zhang","year":"2022","unstructured":"Zhang, Q. Y., S. J. Xu, J. C. Qian, L. B. Yang, P. Q. Chen, and Y. Wang et al. 2022. Pharmacological inhibition of MyD88 suppresses inflammation in tubular epithelial cells and prevents diabetic nephropathy in experimental mice. Acta Pharmacologica Sinica 43(2):354\u2013366. https:\/\/doi.org\/10.1038\/s41401-021-00766-6","journal-title":"Acta Pharmacologica Sinica"}],"container-title":["Inflammation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10753-026-02526-2","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10753-026-02526-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10753-026-02526-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T16:02:26Z","timestamp":1783958546000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10753-026-02526-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,19]]},"references-count":33,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["2526"],"URL":"https:\/\/doi.org\/10.1007\/s10753-026-02526-2","relation":{},"ISSN":["1573-2576"],"issn-type":[{"value":"1573-2576","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,19]]},"assertion":[{"value":"12 February 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 April 2026","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 May 2026","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 May 2026","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All animal experiments in this study were approved by the Medical Ethics Committee of Tianjin Medical University General Hospital (No. IRB2021-DW-52) and the Institutional Animal Care and Use Committee at the University of Iowa (Protocol No. 7021970). All procedures were performed in accordance with the National Institutes of Health Guide for the Care and Use of Laboratory Animals.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical Approval and Consent To Participate"}},{"value":"All authors provided their consent for publication.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for Publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"Not applicable.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Clinical trial number"}}],"article-number":"163"}}