{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T17:50:25Z","timestamp":1773424225663,"version":"3.50.1"},"reference-count":36,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2011,1,29]],"date-time":"2011-01-29T00:00:00Z","timestamp":1296259200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Inflammopharmacol"],"published-print":{"date-parts":[[2011,4]]},"DOI":"10.1007\/s10787-011-0078-4","type":"journal-article","created":{"date-parts":[[2011,1,28]],"date-time":"2011-01-28T18:26:41Z","timestamp":1296239201000},"page":"89-97","source":"Crossref","is-referenced-by-count":8,"title":["Ghrelin suppression of Helicobacter pylori-induced S-nitrosylation-dependent Akt inactivation exerts modulatory influence on gastric mucin synthesis"],"prefix":"10.1007","volume":"19","author":[{"given":"B. L.","family":"Slomiany","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Slomiany","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2011,1,29]]},"reference":[{"key":"78_CR1","doi-asserted-by":"crossref","first-page":"959","DOI":"10.2337\/diabetes.54.4.959","volume":"54","author":"MA Carvalho-Filho","year":"2005","unstructured":"Carvalho-Filho MA, Ueno M, Hirabara SM et al (2005) S-Nitrosation of the insulin receptor, insulin receptor substrate 1, and protein kinase B\/Akt. Diabetes 54:959\u2013967","journal-title":"Diabetes"},{"key":"78_CR2","doi-asserted-by":"crossref","first-page":"E476","DOI":"10.1152\/ajpendo.00422.2005","volume":"291","author":"MA Carvalho-Filho","year":"2006","unstructured":"Carvalho-Filho MA, Ueno M, Carvalheira JBC et al (2006) Targeted disruption of iNOS prevents LPS-induced S-nitrosylation of IR\u03b2\/IRS-1 and Akt and insulin resistance in muscle of mice. Am J Physiol Endocrinol Metab 291:E476\u2013E482","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"78_CR3","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1038\/sj.ki.5002058","volume":"71","author":"S Cuzzocrea","year":"2007","unstructured":"Cuzzocrea S, Salvemini D (2007) Molecular mechanisms involved in the reciprocal regulation of cyclooxygenase and nitric oxide synthase enzymes. Kidney Int 71:290\u2013297","journal-title":"Kidney Int"},{"issue":"suppl 232","key":"78_CR4","first-page":"4","volume":"35","author":"WA deBoer","year":"2000","unstructured":"deBoer WA (2000) Topics in Helicobacter pylori infection: focus on a \u2018search- and -treat\u2019 strategy for ulcer disease. Scand J Gastroenterol 35(suppl 232):4\u20139","journal-title":"Scand J Gastroenterol"},{"key":"78_CR5","doi-asserted-by":"crossref","first-page":"13977","DOI":"10.1074\/jbc.M609684200","volume":"282","author":"MT Forrester","year":"2007","unstructured":"Forrester MT, Forrester MW, Stamler JS (2007) Assessment and application of the biotin switch technique for examining protein S-nitrosylation under conditions of pharmacologically induced oxidative stress. J Biol Chem 282:13977\u201313983","journal-title":"J Biol Chem"},{"key":"78_CR6","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1016\/S0016-5085(99)70496-8","volume":"116","author":"S Fu","year":"1999","unstructured":"Fu S, Ramanujan KS, Wong A et al (1999) Increased expression and cellular localization of inducible nitric oxide synthase and cyclooxygenase-2 in Helicobacter pylori gastritis. Gastroenterology 116:1319\u20131329","journal-title":"Gastroenterology"},{"key":"78_CR7","doi-asserted-by":"crossref","first-page":"31059","DOI":"10.1074\/jbc.M104141200","volume":"276","author":"RA Gupta","year":"2001","unstructured":"Gupta RA, Polk DB, Krishna U et al (2001) Activation of peroxisome proliferator-activated receptor \u03b3 suppresses nuclear factor \u03baB-mediated apoptosis induced by Helicobacter pylori in gastric epithelial cells. J Biol Chem 276:31059\u201331066","journal-title":"J Biol Chem"},{"key":"78_CR8","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.bbapap.2003.11.009","volume":"1697","author":"M Hanada","year":"2004","unstructured":"Hanada M, Feng J, Hemmings BA (2004) Structure, regulation and function of PKB\/AKT\u2014a major therapeutic target. Biochim Biophys Acta Prot Proteom Proteom 1697:3\u201316","journal-title":"Biochim Biophys Acta Prot Proteom Proteom"},{"key":"78_CR9","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.ejphar.2003.09.034","volume":"481","author":"Y Hattori","year":"2003","unstructured":"Hattori Y, Hattori S, Kasai K (2003) Lipopolysaccharide activates Akt in vascular smooth muscle cells resulting in induction of inducible nitric oxide synthase through nuclear factor-kappa B activation. Eur J Pharmacol 481:153\u2013158","journal-title":"Eur J Pharmacol"},{"key":"78_CR10","doi-asserted-by":"crossref","first-page":"2118","DOI":"10.1074\/jbc.M210828200","volume":"278","author":"MP Haynes","year":"2003","unstructured":"Haynes MP, Li L, Sinha D et al (2003) Src kinase mediates phosphatidylinositol 3-kinase\/Akt-dependent rapid endothelial nitric-oxide synthase activation by estrogen. J Biol Chem 278:2118\u20132123","journal-title":"J Biol Chem"},{"key":"78_CR11","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1038\/35055104","volume":"3","author":"SR Jaffrey","year":"2001","unstructured":"Jaffrey SR, Erdjument-Bromage H, Ferris D et al (2001) Protein S-nitrosylation: a physiological signal for neuronal nitric acid. Nat Cell Biol 3:193\u2013197","journal-title":"Nat Cell Biol"},{"key":"78_CR12","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1038\/45230","volume":"402","author":"M Kojima","year":"1999","unstructured":"Kojima M, Hosoda H, Date Y et al (1999) Ghrelin is a growth-hormone-releasing acylated peptide from stomach. Nature 402:656\u2013660","journal-title":"Nature"},{"key":"78_CR13","doi-asserted-by":"crossref","first-page":"471","DOI":"10.2174\/1568010054526359","volume":"4","author":"R Korhonen","year":"2005","unstructured":"Korhonen R, Lahti A, Kankaanranta H, Moilanen E (2005) Nitric oxide production and signaling in inflammation. Curr Drug Targets Inflamm Allergy 4:471\u2013479","journal-title":"Curr Drug Targets Inflamm Allergy"},{"key":"78_CR14","doi-asserted-by":"crossref","first-page":"4699","DOI":"10.1128\/MCB.20.13.4699-4707.2000","volume":"20","author":"M Li","year":"2000","unstructured":"Li M, Pascual G, Glass CK (2000) Peroxisome proliferator-activated receptor \u03b3-dependent repression of the inducible nitric oxide synthase gene. Mol Cell Biol 20:4699\u20134707","journal-title":"Mol Cell Biol"},{"key":"78_CR15","unstructured":"Lodeiro P, Theodoropoulou M, Pardo M et al (2009) c-Src regulates Akt signaling in response to ghrelin via \u03b2-arrestin signaling- independent and \u2013 dependent mechanism. PLoS ONE 4(3):e4686. doi: 10.1371"},{"key":"78_CR16","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1210\/jc.2004-1330","volume":"90","author":"H Osawa","year":"2005","unstructured":"Osawa H, Nakazato M, Date Y et al (2005) Impaired production of gastric ghrelin in chronic gastritis associated with Helicobacter pylori. J Clin Endocrinol Metab 90:10\u201316","journal-title":"J Clin Endocrinol Metab"},{"key":"78_CR17","first-page":"3","volume":"49","author":"J Piotrowski","year":"1998","unstructured":"Piotrowski J (1998) Lipopolysaccharide a virulence factor of Helicobacter pylori. J Physiol Pharmacol 49:3\u201324","journal-title":"J Physiol Pharmacol"},{"key":"78_CR18","doi-asserted-by":"crossref","first-page":"203","DOI":"10.3109\/00365529709000195","volume":"32","author":"J Piotrowski","year":"1997","unstructured":"Piotrowski J, Piotrowski E, Skrodzka D et al (1997) Induction of acute gastritis and epithelial cell apoptosis by Helicobacter pylori lipopolysaccharide. Scand J Gastroenterol 32:203\u2013211","journal-title":"Scand J Gastroenterol"},{"key":"78_CR19","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1078\/1438-4221-00280","volume":"293","author":"G Reider","year":"2003","unstructured":"Reider G, Hofmann JA, Hatz RA et al (2003) Up-regulation of inducible nitric oxide synthase in Helicobacter pylori- associated gastritis may represent an increased risk factor to develop gastric carcinoma of the intestinal type. Int J Med Microbiol 293:403\u2013412","journal-title":"Int J Med Microbiol"},{"key":"78_CR20","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1038\/bjp.2008.120","volume":"154","author":"V Sibilia","year":"2008","unstructured":"Sibilia V, Pagani F, Rindi G et al (2008) Central ghrelin gastroprotection involves nitric oxide\/prostaglandin cross-talk. Br J Pharmacol 154:688\u2013697","journal-title":"Br J Pharmacol"},{"key":"78_CR21","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1007\/978-3-642-78176-6_9","volume-title":"The Stomach","author":"BL Slomiany","year":"1993","unstructured":"Slomiany BL, Slomiany A (1993) Mucus and gastric mucosal protection. In: Domschke W, Konturek SJ (eds) The Stomach. Springer, Berlin, pp 116\u2013143"},{"key":"78_CR22","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1163\/156856000750264438","volume":"8","author":"BL Slomiany","year":"2001","unstructured":"Slomiany BL, Slomiany A (2001) Blockade of p38 mitogen-activated protein kinase pathway inhibits inducible nitric oxide synthase and gastric mucosal inflammatory responses to Helicobacter pylori lipopolysaccharide. Inflammopharmacol 8:371\u2013382","journal-title":"Inflammopharmacol"},{"key":"78_CR23","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1080\/15216540213459","volume":"53","author":"BL Slomiany","year":"2002","unstructured":"Slomiany BL, Slomiany A (2002) Suppression of gastric mucosal inflammatory responses to H. pylori lipopolysaccharide by peroxisome proliferator-activated receptor \u03b3 activation. IUBMB Life 53:303\u2013308","journal-title":"IUBMB Life"},{"key":"78_CR24","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1080\/15216540600732021","volume":"58","author":"BL Slomiany","year":"2006","unstructured":"Slomiany BL, Slomiany A (2006) Cytosolic phospholipase A2 activation in Helicobacter pylori lipopolysaccharide-induced interference with gastric mucin synthesis. IUBMB Life 58:217\u2013223","journal-title":"IUBMB Life"},{"key":"78_CR25","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1007\/s10787-009-0013-0","volume":"17","author":"BL Slomiany","year":"2009","unstructured":"Slomiany BL, Slomiany A (2009) Involvement of constitutive nitric oxide synthase in ghrelin-induced cytosolic phospholipase A2 activation in gastric mucosal cell protection against ethanol cytotoxicity. Inflammopharmacol 17:245\u2013253","journal-title":"Inflammopharmacol"},{"key":"78_CR26","doi-asserted-by":"crossref","unstructured":"Slomiany BL, Slomiany A (2010a) Ghrelin protection against lipopolysaccharide-induced gastric mucosal cell apoptosis involves constitutive nitric oxide synthase-mediated caspase-3 S-nitrosylation. Mediators Inflammation. doi: 1155\/2010\/280464","DOI":"10.1155\/2010\/280464"},{"key":"78_CR27","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1007\/s10787-010-0051-7","volume":"18","author":"BL Slomiany","year":"2010","unstructured":"Slomiany BL, Slomiany A (2010b) Role of constitutive nitric synthase S-nitrosylation in Helicobacter pylori-induced gastric mucosal cell apoptosis: effect of ghrelin. Inflammopharmacol 18:233\u2013240","journal-title":"Inflammopharmacol"},{"key":"78_CR28","doi-asserted-by":"crossref","unstructured":"Slomiany BL, Slomiany A (2010c) Helicobacter pylori induces disturbances in gastric mucosal Akt activation through inducible nitric oxide synthase-dependent S-nitrosylation: effect of ghrelin. ISRN Gastroenterology. doi: 10.5402\/2011\/308727","DOI":"10.5402\/2011\/308727"},{"key":"78_CR29","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.4236\/health.2010.29152","volume":"2","author":"BL Slomiany","year":"2010","unstructured":"Slomiany BL, Slomiany A (2010d) Cytosolic phospholipase A2 S-nitrosylation in ghrelin protection against detrimental effect of ethanol cytotoxicity on gastric mucin synthesis. Health 2:1033\u20131039","journal-title":"Health"},{"key":"78_CR30","doi-asserted-by":"crossref","unstructured":"Stolte M, Edit S (1996) Helicobacter pylori and the evolution of gastritis. Scand J Gastroenterol 31(suppl 214):13\u201316","DOI":"10.3109\/00365529609094508"},{"key":"78_CR31","doi-asserted-by":"crossref","unstructured":"Wagner DA, Glogowski J, Skipper PL et al (1982) Analysis of nitrate, nitrite and [15N]nitrate in biological fluids. Anal Biochem 126:131\u2013138","DOI":"10.1016\/0003-2697(82)90118-X"},{"key":"78_CR32","doi-asserted-by":"crossref","first-page":"4183","DOI":"10.1210\/en.2008-0255","volume":"149","author":"X Xu","year":"2008","unstructured":"Xu X, Jhun BS, Ha CH, Jin ZG (2008) Molecular mechanisms of ghrelin-mediated endothelial nitric-oxide synthase activation. Endocrinology 149:4183\u20134192","journal-title":"Endocrinology"},{"key":"78_CR33","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1016\/S1097-2765(02)00550-6","volume":"9","author":"J Yang","year":"2002","unstructured":"Yang J, Cron P, Thompson V et al (2002) Molecular mechanisms for the regulation of protein kinase B\/Akt by hydrophobic motif phosphorylation. Mol Cell 9:1227\u20131240","journal-title":"Mol Cell"},{"key":"78_CR34","doi-asserted-by":"crossref","first-page":"7511","DOI":"10.1074\/jbc.M411871200","volume":"280","author":"T Yasukawa","year":"2005","unstructured":"Yasukawa T, Tokunaga E, Ota H et al (2005) S-Nitrosylation-dependent inactivation of Akt\/protein kinase B in insulin resistance. J Biol Chem 280:7511\u20137518","journal-title":"J Biol Chem"},{"key":"78_CR35","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1042\/bj3280363","volume":"328","author":"SM Yu","year":"1997","unstructured":"Yu SM, Wu JF, Lin TL, Kuo SC (1997) Inhibition of nitric synthase expression by PPM-18, a novel anti-inflammatory agent, in vitro and in vivio. Biochem J 328:363\u2013369","journal-title":"Biochem J"},{"key":"78_CR36","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.cgh.2009.07.017","volume":"8","author":"A Zullo","year":"2009","unstructured":"Zullo A, Hassan C, Cristofari F et al (2009) Effects of Helicobacter pylori eradication on early stage gastric mucosa-associated lymphoid tissue lymphoma. Clin Gastroenterol Hepatol 8:105\u2013110","journal-title":"Clin Gastroenterol Hepatol"}],"container-title":["Inflammopharmacology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10787-011-0078-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10787-011-0078-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10787-011-0078-4","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,6,8]],"date-time":"2019-06-08T05:57:00Z","timestamp":1559973420000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10787-011-0078-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,1,29]]},"references-count":36,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2011,4]]}},"alternative-id":["78"],"URL":"https:\/\/doi.org\/10.1007\/s10787-011-0078-4","relation":{},"ISSN":["0925-4692","1568-5608"],"issn-type":[{"value":"0925-4692","type":"print"},{"value":"1568-5608","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,1,29]]}}}