{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,13]],"date-time":"2026-11-13T17:39:03Z","timestamp":1794591543097,"version":"4.9.1"},"reference-count":36,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2011,11,1]],"date-time":"2011-11-01T00:00:00Z","timestamp":1320105600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Inflammopharmacol"],"published-print":{"date-parts":[[2011,12]]},"DOI":"10.1007\/s10787-011-0098-0","type":"journal-article","created":{"date-parts":[[2011,11,2]],"date-time":"2011-11-02T15:56:17Z","timestamp":1320249377000},"page":"299-306","source":"Crossref","is-referenced-by-count":97,"title":["Anti-inflammatory activity of chondroitin sulphate: new functions from an old natural macromolecule"],"prefix":"10.1007","volume":"19","author":[{"given":"Nicola","family":"Volpi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2011,11,1]]},"reference":[{"key":"98_CR1","doi-asserted-by":"crossref","unstructured":"Bauerova K, Ponist S, Kuncirova V, Mihalova D, Paulovicova E, Volpi N (2011) Protective effect of chondroitin sulfate on induced arthritis in rats. Osteoarthr Cartil 19:1373\u20131379","DOI":"10.1016\/j.joca.2011.08.006"},{"key":"98_CR2","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1177\/019262339902700125","volume":"27","author":"A Bendele","year":"1999","unstructured":"Bendele A, McComb J, Gould T, McAbee T, Sennello G, Chlipala E, Guy M (1999) Animal models of arthritis: relevance to human disease. Toxicol Pathol 27:134\u2013142","journal-title":"Toxicol Pathol"},{"key":"98_CR3","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1002\/art.1780400104","volume":"40","author":"GR Burmester","year":"1997","unstructured":"Burmester GR, Stuhlmuller B, Keyszer G, Kinne RW (1997) Mononuclear phagocytes and rheumatoid synovitis. Mastermind or workhorse in arthritis? Arthritis Rheum 40:5\u201318","journal-title":"Arthritis Rheum"},{"key":"98_CR4","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1177\/1753425908094725","volume":"14","author":"GM Campo","year":"2008","unstructured":"Campo GM, Avenoso A, Campo S, D\u2019Ascola A, Traina P, Sam\u00e0 D, Calatroni A (2008) Purified human plasma glycosaminoglycans reduced NF-kappaB activation, pro-inflammatory cytokine production and apoptosis in LPS-treated chondrocytes. Innate Immun 14:233\u2013246","journal-title":"Innate Immun"},{"key":"98_CR5","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.abb.2009.09.017","volume":"491","author":"GM Campo","year":"2009","unstructured":"Campo GM, Avenoso A, Campo S, Traina P, D\u2019Ascola A, Calatroni A (2009) Glycosaminoglycans reduced inflammatory response by modulating toll-like receptor-4 in LPS-stimulated chondrocytes. Arch Biochem Biophys 491:7\u201315","journal-title":"Arch Biochem Biophys"},{"key":"98_CR6","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1016\/j.neuroscience.2010.02.069","volume":"167","author":"N Ca\u00f1as","year":"2010","unstructured":"Ca\u00f1as N, Gorina R, Planas AM, Verg\u00e9s J, Montell E, Garc\u00eda AG, L\u00f3pez MG (2010) Chondroitin sulfate inhibits lipopolysaccharide-induced inflammation in rat astrocytes by preventing nuclear factor kappa B activation. Neuroscience 167:872\u2013879","journal-title":"Neuroscience"},{"key":"98_CR7","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1248\/bpb.27.47","volume":"27","author":"SY Cho","year":"2004","unstructured":"Cho SY, Sim JS, Jeong CS, Chang SY, Choi DW, Toida T, Kim YS (2004) Effects of low molecular weight chondroitin sulfate on type II collagen-induced arthritis in DBA\/1J mice. Biol Pharm Bull 27:47\u201351","journal-title":"Biol Pharm Bull"},{"key":"98_CR8","doi-asserted-by":"crossref","first-page":"10057","DOI":"10.1073\/pnas.94.19.10057","volume":"94","author":"ZL Chu","year":"1997","unstructured":"Chu ZL, McKinsey TA, Liu L, Gentry JJ, Malim MH, Ballard DW (1997) Suppression of tumor necrosis factor-induced cell death by inhibitor of apoptosis c-IAP2 is under NF-kappaB control. Proc Natl Acad Sci USA 94:10057\u201310062","journal-title":"Proc Natl Acad Sci USA"},{"key":"98_CR9","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1097\/CCM.0b013e31819267fb","volume":"37","author":"I Cinel","year":"2009","unstructured":"Cinel I, Opal SM (2009) Molecular biology of inflammation and sepsis: a primer. Crit Care Med 37:291\u2013304","journal-title":"Crit Care Med"},{"issue":"Suppl 1","key":"98_CR10","doi-asserted-by":"crossref","first-page":"S24","DOI":"10.1016\/j.joca.2010.01.016","volume":"18","author":"J Egea","year":"2010","unstructured":"Egea J, Garc\u00eda AG, Verges J, Montell E, L\u00f3pez MG (2010) Antioxidant, antiinflammatory and neuroprotective actions of chondroitin sulfate and proteoglycans. Osteoarthr Cartil 18(Suppl 1):S24\u2013S27","journal-title":"Osteoarthr Cartil"},{"key":"98_CR11","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1038\/nri2423","volume":"8","author":"S Ghosh","year":"2008","unstructured":"Ghosh S, Hayden MS (2008) New regulators of NF-kappaB in inflammation. Nat Rev Immunol 8:837\u2013848","journal-title":"Nat Rev Immunol"},{"key":"98_CR12","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1038\/bjp.2008.113","volume":"154","author":"G Herrero-Beaumont","year":"2008","unstructured":"Herrero-Beaumont G, Marcos ME, S\u00e1nchez-Pernaute O, Granados R, Ortega L, Montell E, Verg\u00e9s J, Egido J, Largo R (2008) Effect of chondroitin sulphate in a rabbit model of atherosclerosis aggravated by chronic arthritis. Br J Pharmacol 154:843\u2013851","journal-title":"Br J Pharmacol"},{"key":"98_CR13","doi-asserted-by":"crossref","first-page":"2868","DOI":"10.5897\/AJB2007.000-2457","volume":"6","author":"EO Iwalewa","year":"2007","unstructured":"Iwalewa EO, McGaw LJ, Naidoo V, Eloff JN (2007) Inflammation: the foundation of disease and disorders. A review of phytomedicines of South African origin used to treat pain and inflammatory conditions. Afr J Biotech 6:2868\u20132885","journal-title":"Afr J Biotech"},{"key":"98_CR14","first-page":"594","volume":"16","author":"C-H Jin","year":"2007","unstructured":"Jin C-H, Yang U, Kim S-H, Ryu J-W, Lee J-C, Lee D-S, Lee T-H (2007) The protective effect of chondroitin from Raja kenojei cartilage on collagen-induced arthritis in DBA\/1. J Mice Food Sci Biotechnol 16:594\u2013599","journal-title":"J Mice Food Sci Biotechnol"},{"key":"98_CR15","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1111\/j.1742-7843.2007.00158.x","volume":"102","author":"C Jomphe","year":"2008","unstructured":"Jomphe C, Gabriac M, Hale TM, H\u00e9roux L, Trudeau LE, Deblois D, Montell E, Verg\u00e9s J, du Souich P (2008) Chondroitin sulfate inhibits the nuclear translocation of nuclear factor-kappaB in interleukin-1beta-stimulated chondrocytes. Basic Clin Pharmacol Toxicol 102:59\u201365","journal-title":"Basic Clin Pharmacol Toxicol"},{"key":"98_CR16","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1136\/ard.2003.011742","volume":"62","author":"KM Jordan","year":"2003","unstructured":"Jordan KM, Arden NK, Doherty M, Bannwarth B, Bijlsma JW, Dieppe P et al (2003) EULAR Recommendations 2003: an evidence based approach to the management of knee osteoarthritis: report of a task force of the Standing Committee for International Clinical Studies Including Therapeutic Trials (ESCISIT). Ann Rheum Dis 62:1145\u20131155","journal-title":"Ann Rheum Dis"},{"key":"98_CR17","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1002\/art.24255","volume":"60","author":"A Kahan","year":"2009","unstructured":"Kahan A, Uebelhart D, De Vathaire F, Delmas PD, Reginster JY (2009) Long-term effects of chondroitins 4 and 6 sulfate on knee osteoarthritis: the study on osteoarthritis progression prevention, a two-year, randomized, double-blind, placebo-controlled trial. Arthritis Rheum 60:524\u2013533","journal-title":"Arthritis Rheum"},{"key":"98_CR18","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.pathophys.2005.07.011","volume":"12","author":"K Kannan","year":"2005","unstructured":"Kannan K, Ortmann RA, Kimpel D (2005) Animal models of rheumatoid arthritis and their relevance to human disease. Pathophysiology 12:167\u2013181","journal-title":"Pathophysiology"},{"key":"98_CR19","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1038\/ni0302-221","volume":"3","author":"M Karin","year":"2002","unstructured":"Karin M, Lin A (2002) NF-kappaB at the crossroads of life and death. Nat Immunol 3:221\u2013227","journal-title":"Nat Immunol"},{"key":"98_CR20","unstructured":"Kingston AE, Carney SL, Hicks CA, Billingham MEJ (1993) Arthritis and Osteoarthritis. Birkhauser, Basel, pp 75\u201379"},{"key":"98_CR21","first-page":"148","volume":"50","author":"T Omata","year":"2000","unstructured":"Omata T, Itokazu Y, Inoue N, Segawa Y (2000) Effects of chondroitin sulfate-C on articular cartilage destruction in murine collagen-induced arthritis. Arzneimittelforschung 50:148\u2013153","journal-title":"Arzneimittelforschung"},{"key":"98_CR22","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.2174\/138955707782110088","volume":"7","author":"JY Reginster","year":"2007","unstructured":"Reginster JY, Heraud F, Zegels B, Bruyere O (2007) Symptom and structure modifying properties of chondroitin sulfate in osteoarthritis. Mini Rev Med Chem 7:1051\u20131061","journal-title":"Mini Rev Med Chem"},{"issue":"Suppl A","key":"98_CR23","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/S1063-4584(98)80006-X","volume":"6","author":"F Ronca","year":"1998","unstructured":"Ronca F, Palmieri L, Panicucci P, Ronca G (1998) Anti-inflammatory activity of chondroitin sulfate. Osteoarthr Cartil 6(Suppl A):14\u201321","journal-title":"Osteoarthr Cartil"},{"key":"98_CR24","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1038\/nrd1521","volume":"3","author":"Z Shriver","year":"2004","unstructured":"Shriver Z, Raguram S, Sasisekharan R (2004) Glycomics: a pathway to a class of new and improved therapeutics. Nat Rev Drug Discov 3:863\u2013873","journal-title":"Nat Rev Drug Discov"},{"key":"98_CR25","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.plipres.2010.07.005","volume":"50","author":"MJ Stables","year":"2011","unstructured":"Stables MJ, Gilroy DW (2011) Old and new generation lipid mediators in acute inflammation and resolution. Progr Lipid Res 50:35\u201351","journal-title":"Progr Lipid Res"},{"key":"98_CR26","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1016\/j.sbi.2003.09.011","volume":"13","author":"K Sugahara","year":"2003","unstructured":"Sugahara K, Mikami T, Uyama T, Mizuguchi S, Nomura K, Kitagawa H (2003) Recent advances in the structural biology of chondroitin sulfate and dermatan sulfate. Curr Opin Struct Biol 13:612\u2013620","journal-title":"Curr Opin Struct Biol"},{"key":"98_CR27","doi-asserted-by":"crossref","first-page":"S19","DOI":"10.1016\/j.joca.2008.06.006","volume":"16","author":"D Uebelhart","year":"2008","unstructured":"Uebelhart D (2008) Clinical review of chondroitin sulfate in osteoarthritis. Osteoarthr Cartil 16:S19\u2013S21","journal-title":"Osteoarthr Cartil"},{"issue":"Suppl A","key":"98_CR28","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/S1063-4584(98)80005-8","volume":"6","author":"D Uebelhart","year":"1998","unstructured":"Uebelhart D, Thonar EJ, Zhang J, Williams JM (1998) Protective effect of exogenous chondroitin 4,6-sulfate in the acute degradation of articular cartilage in the rabbit. Osteoarthr Cartil 6(Suppl A):6\u201313","journal-title":"Osteoarthr Cartil"},{"issue":"Suppl 1","key":"98_CR29","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1016\/j.joca.2010.02.017","volume":"18","author":"M Valli\u00e8res","year":"2010","unstructured":"Valli\u00e8res M, du Souich P (2010) Modulation of inflammation by chondroitin sulfate. Osteoarthr Cartil 18(Suppl 1):S1\u2013S6","journal-title":"Osteoarthr Cartil"},{"key":"98_CR30","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1016\/j.intimp.2010.06.014","volume":"10","author":"ESO Vanderlei","year":"2010","unstructured":"Vanderlei ESO, Patoilo KKNR, Lima NA, Lima APS, Rodrigues JAG, Silva LMCM, Lima MEP, Lima V, Benevides NMB (2010) Antinociceptive and anti-inflammatory activities of lectin from the marine green alga Caulerpa cupressoides. Int Immunopharmacol 10:1113\u20131118","journal-title":"Int Immunopharmacol"},{"key":"98_CR31","doi-asserted-by":"crossref","first-page":"3168","DOI":"10.1002\/jps.20997","volume":"96","author":"N Volpi","year":"2007","unstructured":"Volpi N (2007) Analytical aspects of pharmaceutical grade chondroitin sulfates. J Pharm Sci 96:3168\u20133180","journal-title":"J Pharm Sci"},{"key":"98_CR32","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1211\/jpp.61.10.0002","volume":"61","author":"N Volpi","year":"2009","unstructured":"Volpi N (2009) Quality of different chondroitin sulfate preparations in relation to their therapeutic activity. Pharm Pharmacol 61:1271\u20131280","journal-title":"Pharm Pharmacol"},{"key":"98_CR33","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.carbpol.2010.05.009","volume":"82","author":"N Volpi","year":"2010","unstructured":"Volpi N (2010) Dermatan sulfate: recent structural and activity data. Carb Polymers 82:233\u2013239","journal-title":"Carb Polymers"},{"key":"98_CR34","doi-asserted-by":"crossref","first-page":"289","DOI":"10.2174\/157016308786733564","volume":"5","author":"S Yamada","year":"2008","unstructured":"Yamada S, Sugahara K (2008) Potential therapeutic application of chondroitin sulfate\/dermatan sulfate. Curr Drug Discov Technol 5:289\u2013301","journal-title":"Curr Drug Discov Technol"},{"key":"98_CR35","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1136\/ard.2006.062091","volume":"66","author":"W Zhang","year":"2007","unstructured":"Zhang W, Doherty M, Leeb BF, Alekseeva L, Arden NK, Bijlsma JW et al (2007) EULAR evidence based recommendations for the management of hand osteoarthritis: report of a task force of the EULAR Standing Committee for International Clinical Studies Including Therapeutics (ESCISIT). Ann Rheum Dis 66:377\u2013388","journal-title":"Ann Rheum Dis"},{"key":"98_CR36","doi-asserted-by":"crossref","first-page":"24246","DOI":"10.1074\/jbc.M703422200","volume":"282","author":"J Zhong","year":"2007","unstructured":"Zhong J, Kyriakis JM (2007) Dissection of a signaling pathway by which pathogen-associated molecular patterns recruit the JNK and p38 MAPKs and trigger cytokine release. J Biol Chem 282:24246\u201324254","journal-title":"J Biol Chem"}],"container-title":["Inflammopharmacology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10787-011-0098-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10787-011-0098-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10787-011-0098-0","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,14]],"date-time":"2024-04-14T10:19:51Z","timestamp":1713089991000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10787-011-0098-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,11,1]]},"references-count":36,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2011,12]]}},"alternative-id":["98"],"URL":"https:\/\/doi.org\/10.1007\/s10787-011-0098-0","relation":{},"ISSN":["0925-4692","1568-5608"],"issn-type":[{"value":"0925-4692","type":"print"},{"value":"1568-5608","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,11,1]]}}}