{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T07:38:08Z","timestamp":1771918688831,"version":"3.50.1"},"reference-count":43,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2012,3,23]],"date-time":"2012-03-23T00:00:00Z","timestamp":1332460800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Inflammopharmacol"],"published-print":{"date-parts":[[2012,10]]},"DOI":"10.1007\/s10787-012-0132-x","type":"journal-article","created":{"date-parts":[[2012,3,23]],"date-time":"2012-03-23T12:33:19Z","timestamp":1332505999000},"page":"267-275","source":"Crossref","is-referenced-by-count":8,"title":["Atorvastatin inhibits the inflammatory response caused by anti-M3 peptide IgG in patients with primary Sj\u00f6gren\u2019s syndrome"],"prefix":"10.1007","volume":"20","author":[{"given":"Silvia","family":"Reina","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniela","family":"Passafaro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leonor","family":"Sterin-Borda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Enri","family":"Borda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2012,3,23]]},"reference":[{"key":"132_CR1","first-page":"151","volume":"39","author":"S Bacman","year":"1998","unstructured":"Bacman S, Perez Leiros C, Sterin-Borda L, Hubscher O, Arana R, Borda E (1998) Autoantibodies against lacrimal gland M3 muscarinic acetylcholine receptors in patients with primary Sj\u00f6gren\u2019s syndrome. Invest Ophthalmol Vis Sci 39:151\u2013156","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"132_CR2","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1016\/j.ejphar.2005.05.005","volume":"516","author":"MM Barsante","year":"2005","unstructured":"Barsante MM, Roffe E, Yokoro CM, Tafuri WL, Souza DG, Pinho V et al (2005) Anti-inflammatory and analgesic effects of atorvastatin in a rat model of adjuvant-induced arthritis. Eur J Pharmacol 516:282\u2013289","journal-title":"Eur J Pharmacol"},{"key":"132_CR3","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1080\/03009740902973821","volume":"38","author":"R Baturone","year":"2009","unstructured":"Baturone R, Soto MJ, M\u00e1rquez M, Mac\u00edas I, de Oca MM, Medina F, Chozas N, Garc\u00eda-P\u00e9rez S, Gir\u00f3n-Gonz\u00e1lez JA (2009) Health-related quality of life in patients with primary Sj\u00f6gren\u2019s syndrome: relationship with serum levels of proinflammatory cytokines. Scand J Rheumatol 38:386\u2013389","journal-title":"Scand J Rheumatol"},{"key":"132_CR4","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1046\/j.1523-1755.2003.00744.x","volume":"63","author":"LM Blanco-Colio","year":"2003","unstructured":"Blanco-Colio LM, Tunon J, Martin-Ventura JL, Egido J (2003) Anti-inflammatory and immunomodulatory effects of statins. Kidney Int 63:12\u201323","journal-title":"Kidney Int"},{"key":"132_CR5","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1002\/art.10734","volume":"48","author":"AI Bolstad","year":"2003","unstructured":"Bolstad AI, Eiken HG, Rosenlund B, Alarc\u00f3n-Riquelme ME, Jonsson R (2003) Increased salivary gland tissue expression of Fas, Fas ligand, cytotoxic T lymphocyte-associated antigen 4, and programmed cell death 1 in primary Sj\u00f6gren\u2019s syndrome. Arthritis Rheum 48:174\u2013185","journal-title":"Arthritis Rheum"},{"key":"132_CR6","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1006\/jaut.2000.0461","volume":"16","author":"E Borda","year":"2001","unstructured":"Borda E, Sterin-Borda L (2001) Autoantibodies against neonatal heart M1 muscarinic acetylcholine receptor in children with congenital heart block. J Autoimmun 16:143\u2013150","journal-title":"J Autoimmun"},{"key":"132_CR7","doi-asserted-by":"crossref","first-page":"256","DOI":"10.4236\/pp.2011.24033","volume":"2","author":"E Borda","year":"2011","unstructured":"Borda E, Passafaro D, Reina S, Sterin-Borda L (2011) Modulation of c-Jun NH2-terminal (JNK) by cholinergic autoantibodies from patients with Sj\u00f6gren\u2019s syndrome. Pharmacol Pharm 2:256\u2013265","journal-title":"Pharmacol Pharm"},{"key":"132_CR8","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/0006-8993(96)00575-6","volume":"733","author":"C Cao","year":"1996","unstructured":"Cao C, Matsumura K, Yamagata K, Watanabe Y (1996) Endothelial cells of the rat brain vasculature express cyclooxygenase-2 mRNA in response to systemic interleukin-1 beta: a possible site of prostaglandin synthesis responsible for fever. Brain Res 733:263\u2013272","journal-title":"Brain Res"},{"key":"132_CR9","doi-asserted-by":"crossref","first-page":"21A","DOI":"10.1016\/S0002-9149(05)80011-6","volume":"76","author":"A Corsini","year":"1995","unstructured":"Corsini A, Raiteri M, Soma MR, Bernini F, Fumagalli R, Paoletti R (1995) Pathogenesis of atherosclerosis and the role of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors. Am J Cardiol 76:21A\u201328A","journal-title":"Am J Cardiol"},{"key":"132_CR10","doi-asserted-by":"crossref","first-page":"1755","DOI":"10.1073\/pnas.0409225102","volume":"102","author":"TM Cunha","year":"2005","unstructured":"Cunha TM, Verri WA Jr, Silva JS, Poole S, Cunha FQ, Ferreira SH (2005) A cascade of cytokines mediates mechanical inflammatory hypernociception in mice. Proc Natl Acad Sci USA 102:1755\u20131760","journal-title":"Proc Natl Acad Sci USA"},{"key":"132_CR11","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/S0140-6736(05)66990-5","volume":"366","author":"RI Fox","year":"2005","unstructured":"Fox RI (2005) Sj\u00f6gren\u2019s syndrome. Lancet 366:321\u2013331","journal-title":"Lancet"},{"key":"132_CR12","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/S0022-3565(25)12610-4","volume":"254","author":"KR Gans","year":"1990","unstructured":"Gans KR, Galbraith W, Roman RJ, Haber SB, Kerr JS, Schmidt WK, Smith C, Hewes WE, Ackerman NR (1990) Anti-inflammatory and safety profile of DuP 697, a novel orally effective prostaglandin synthesis inhibitor. J Pharmacol Exp Ther 254:180\u2013187","journal-title":"J Pharmacol Exp Ther"},{"key":"132_CR13","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1096\/fasebj.11.1.9034169","volume":"10","author":"JC Goin","year":"1997","unstructured":"Goin JC, Perez-Leiros C, Borda E, Sterin-Borda L (1997) Interaction of human chagasic IgG with the second extracellular loop of the human heart muscarinic acetylcholine receptor: functional and pathological implications. FASEB J 10:77\u201383","journal-title":"FASEB J"},{"key":"132_CR14","doi-asserted-by":"crossref","first-page":"2240","DOI":"10.1002\/art.11103","volume":"48","author":"JE Gottenberg","year":"2003","unstructured":"Gottenberg JE, Busson M, Loiseau P et al (2003) In primary Sj\u00f6gren\u2019s syndrome, HLA class II is associated exclusively with autoantibody production and spreading of the autoimmune response. Arthritis Rheum 48:2240\u20132245","journal-title":"Arthritis Rheum"},{"key":"132_CR15","doi-asserted-by":"crossref","first-page":"2770","DOI":"10.1073\/pnas.0510837103","volume":"103","author":"JE Gottenberg","year":"2006","unstructured":"Gottenberg JE, Cagnard N, Lucchesi C et al (2006) Activation of IFN pathways and plasmacytoid dendritic cell recruitment in target organs of primary Sj\u00f6gren\u2019s syndrome. Proc Natl Acad Sci USA 103:2770\u20132775","journal-title":"Proc Natl Acad Sci USA"},{"key":"132_CR16","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1056\/NEJM198807073190105","volume":"319","author":"SM Grundy","year":"1988","unstructured":"Grundy SM (1988) HMG-CoA reductase inhibitors for treatment of hypercholesterolemia. N Engl J Med 319:24\u201333","journal-title":"N Engl J Med"},{"key":"132_CR17","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1007\/BF03167690","volume":"169","author":"A Heerey","year":"2000","unstructured":"Heerey A, Barry M, Ryan M, Kelly A (2000) The potential for drug interactions with statin therapy in Ireland. Ir J Med Sci 169:176\u2013179","journal-title":"Ir J Med Sci"},{"key":"132_CR18","doi-asserted-by":"crossref","first-page":"563","DOI":"10.2165\/00003495-199753040-00003","volume":"53","author":"JY Jouzeau","year":"1997","unstructured":"Jouzeau JY, Terlain B, Abid A, N\u00e9d\u00e9lec E, Netter P (1997) Cyclo-oxygenase isoenzymes. How recent findings affect thinking about nonsteroidal anti-inflammatory drugs. Drugs 53:563\u2013582","journal-title":"Drugs"},{"key":"132_CR19","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1016\/S0008-6363(00)00146-2","volume":"47","author":"KK Koh","year":"2000","unstructured":"Koh KK (2000) Effects of statins on vascular wall: vasomotor function, inflammation, and plaque stability. Cardiovasc Res 47:648\u2013657","journal-title":"Cardiovasc Res"},{"key":"132_CR20","doi-asserted-by":"crossref","first-page":"1524","DOI":"10.4049\/jimmunol.170.3.1524","volume":"170","author":"BP Leung","year":"2003","unstructured":"Leung BP, Sattar N, Crilly A, Prach M, McCarey DW, Payne H et al (2003) A novel anti-inflammatory role for simvastatin in inflammatory arthritis. J Immunol 170:1524\u20131530","journal-title":"J Immunol"},{"key":"132_CR21","first-page":"148","volume":"25","author":"JR Lowry","year":"1950","unstructured":"Lowry JR, Thiessen R Jr (1950) Studies of the nutritive impairment of proteins heated with carbohydrates; in vitro digestion studies. Arch Biochem 25:148\u2013156","journal-title":"Arch Biochem"},{"key":"132_CR22","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1093\/rheumatology\/keq042","volume":"49","author":"T Mandl","year":"2010","unstructured":"Mandl T, Hammar O, Theander E, Wollmer P, Ohlsson B (2010) Autonomic nervous dysfunction development in patients with primary Sjogren\u2019s syndrome: a follow-up study. Rheumatology (Oxford) 49:1101\u20131106","journal-title":"Rheumatology (Oxford)"},{"key":"132_CR23","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.trsl.2006.07.003","volume":"148","author":"H Nakamura","year":"2006","unstructured":"Nakamura H, Kawakami A, Eguchi K (2006) Mechanisms of autoantibody production and the relationship between autoantibodies and the clinical manifestations in Sj\u00f6gren\u2019s syndrome. Transat Res 148:281\u2013288","journal-title":"Transat Res"},{"key":"132_CR24","doi-asserted-by":"crossref","first-page":"19","DOI":"10.2165\/00002512-200825010-00003","volume":"25","author":"KP Ng","year":"2008","unstructured":"Ng KP, Isenberg DA (2008) Sj\u00f6gren\u2019s syndrome: diagnosis and therapeutic challenges in the elderly. Drugs Aging 25:19\u201333","journal-title":"Drugs Aging"},{"key":"132_CR25","doi-asserted-by":"crossref","first-page":"2730","DOI":"10.1002\/art.10577","volume":"46","author":"N Ogawa","year":"2002","unstructured":"Ogawa N, Ping L, Zhenjun L, Takada Y, Sugai S (2002) Involvement of the interferon-gamma-induced T cell-attracting chemokines, interferon-gamma-inducible 10-kd protein (CXCL10) and monokine induced by interferon-gamma (CXCL9), in the salivary gland lesions of patients with Sj\u00f6gren\u2019s syndrome. Arthritis Rheum 46:2730\u20132741","journal-title":"Arthritis Rheum"},{"key":"132_CR26","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/j.ajo.2003.10.036","volume":"137","author":"SC Pflugfelder","year":"2004","unstructured":"Pflugfelder SC (2004) Antiinflammatory therapy for dry eye. Am J Ophthalmol 137:337\u2013342","journal-title":"Am J Ophthalmol"},{"key":"132_CR27","doi-asserted-by":"crossref","first-page":"2683","DOI":"10.1083\/jcb.103.6.2683","volume":"103","author":"A Rapraeger","year":"1986","unstructured":"Rapraeger A, Jalkanen M, Bernfield MJ (1986) Cell surface proteoglycan associates with the cytoskeleton at the basolateral cell surface of mouse mammary epithelial cells. Cell Biol 103:2683\u20132696","journal-title":"Cell Biol"},{"key":"132_CR28","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.jneuroim.2004.01.019","volume":"150","author":"S Reina","year":"2004","unstructured":"Reina S, Sterin-Borda L, Orman B, Borda E (2004) Autoantibodies against cerebral muscarinic cholinoceptors in Sj\u00f6gren syndrome: functional and pathological implications. J Neuroimmunol 150:107\u2013115","journal-title":"J Neuroimmunol"},{"key":"132_CR29","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1177\/154405910708600905","volume":"86","author":"S Reina","year":"2007","unstructured":"Reina S, Orman B, Anaya JM, Sterin-Borda L, Borda E (2007) Cholinoreceptor autoantibodies in Sj\u00f6gren syndrome. J Dent Res 86:832\u2013836","journal-title":"J Dent Res"},{"key":"132_CR30","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1002\/jcp.21981","volume":"222","author":"S Reina","year":"2010","unstructured":"Reina S, Sterin-Borda L, Passafaro D, Borda E (2010) Muscarinic cholinoceptor activation by pilocarpine triggers apoptosis in human skin fibroblast cells. J Cell Physiol 222:640\u2013647","journal-title":"J Cell Physiol"},{"key":"132_CR31","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/j.archoralbio.2010.08.017","volume":"56","author":"S Reina","year":"2011","unstructured":"Reina S, Sterin-Borda L, Passafaro D, Borda E (2011a) Anti-M(3) muscarinic cholinergic autoantibodies from patients with primary Sj\u00f6gren\u2019s syndrome trigger production of matrix metalloproteinase-3 (MMP-3) and prostaglandin E2 (PGE2) from the submandibular glands. Arch Oral Biol 56:413\u2013420","journal-title":"Arch Oral Biol"},{"key":"132_CR32","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/j.archoralbio.2010.08.017","volume":"56","author":"S Reina","year":"2011","unstructured":"Reina S, Sterin-Borda L, Passafaro D, Borda E (2011b) Anti-M(3) muscarinic cholinergic autoantibodies from patients with primary Sj\u00f6gren\u2019s syndrome trigger production of matrix metalloproteinase-3 (MMP-3) and prostaglandin E(2) (PGE(2)) from the submandibular glands. Arch Oral Biol 56:413\u2013420","journal-title":"Arch Oral Biol"},{"key":"132_CR33","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1002\/glia.10108","volume":"39","author":"GA Rosenberg","year":"2002","unstructured":"Rosenberg GA (2002) Matrix metalloproteinases in neuroinflammation. Glia 39:279\u2013291","journal-title":"Glia"},{"key":"132_CR34","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1007\/s11886-999-0027-7","volume":"1","author":"RS Rosenson","year":"1999","unstructured":"Rosenson RS (1999) Non-lipid-lowering effects of statins on atherosclerosis. Curr Cardiol Rep 1:225\u2013232","journal-title":"Curr Cardiol Rep"},{"key":"132_CR35","doi-asserted-by":"crossref","first-page":"3680","DOI":"10.1073\/pnas.0308382101","volume":"101","author":"D Sachs","year":"2004","unstructured":"Sachs D, Cunha FQ, Ferreira SH (2004) Peripheral analgesic blockade of hypernociception: activation of arginine\/NO\/cGMP\/protein kinase G\/ATP-sensitive K+ channel pathway. Proc Natl Acad Sci USA 101:3680\u20133685","journal-title":"Proc Natl Acad Sci USA"},{"key":"132_CR36","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1038\/sj.bjp.0706836","volume":"149","author":"T Santodomingo-Garz\u00f3n","year":"2006","unstructured":"Santodomingo-Garz\u00f3n T, Cunha TM, Verri WA Jr et al (2006) Atorvastatin inhibits inflammatory hypernociception. Br J Pharmacol 149:14\u201322","journal-title":"Br J Pharmacol"},{"key":"132_CR37","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/S0021-9150(00)00725-5","volume":"157","author":"S Solheim","year":"2001","unstructured":"Solheim S, Seljeflot I, Arnesen H, Eritsland J, Eikvar L (2001) Reduced levels of TNF alpha in hypercholesterolemic individuals after treatment with pravastatin for 8\u00a0weeks. Atherosclerosis 157:411\u2013415","journal-title":"Atherosclerosis"},{"key":"132_CR38","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1038\/labinvest.3780221","volume":"81","author":"S Steinfeld","year":"2001","unstructured":"Steinfeld S, Cogan E, King LS, Agre P, Kiss R, Delporte C (2001) Abnormal distribution of aquaporin-5 water channel protein in salivary glands from Sj\u00f6gren\u2019s syndrome patients. Lab Invest 81:143\u2013148","journal-title":"Lab Invest"},{"key":"132_CR39","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1016\/j.autrev.2010.05.008","volume":"9","author":"T Sumida","year":"2010","unstructured":"Sumida T, Tsuboi H, Iizuka M, Nakamura Y, Matsumoto I (2010) Functional role of M3 muscarinic acetylcholine receptor (M3R) reactive T cells and anti-M3R autoantibodies in patients with Sj\u00f6gren\u2019s syndrome. Autoimmun Rev 9:615\u2013617","journal-title":"Autoimmun Rev"},{"key":"132_CR40","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/0014-2999(94)90398-0","volume":"251","author":"CR Tonussi","year":"1994","unstructured":"Tonussi CR, Ferreira SH (1994) Mechanism of diclofenac analgesia: direct blockade of inflammatory sensitization. Eur J Pharmacol 251:173\u2013179","journal-title":"Eur J Pharmacol"},{"key":"132_CR41","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1002\/art.1780360309","volume":"36","author":"C Vitali","year":"1993","unstructured":"Vitali C, Bombardieri S, Moutsopoulos HM, Balestrieri G, Bencivelli W, Bernstein RM (1993) Preliminary criteria for the classification of Sj\u00f6gren\u2019s syndrome. Results from a prospective concerted action supported by the European Community. Arthritis Rheum 36:340\u2013347","journal-title":"Arthritis Rheum"},{"key":"132_CR42","doi-asserted-by":"crossref","first-page":"1647","DOI":"10.1002\/1529-0131(200007)43:7<1647::AID-ANR31>3.0.CO;2-P","volume":"43","author":"SA Waterman","year":"2000","unstructured":"Waterman SA, Gordon TP, Rischmueller M (2000) Inhibitory effects of muscarinic receptor autoantibodies on parasympathetic neurotransmission in Sj\u00f6gren\u2019s syndrome. Arthritis Rheum 43:1647\u20131654","journal-title":"Arthritis Rheum"},{"key":"132_CR43","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1016\/S0165-6147(02)02077-1","volume":"23","author":"G Weitz-Schmidt","year":"2002","unstructured":"Weitz-Schmidt G (2002) Statins as anti-inflammatory agents. Trends Pharmacol Sci 23:482\u2013486","journal-title":"Trends Pharmacol Sci"}],"container-title":["Inflammopharmacology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10787-012-0132-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10787-012-0132-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10787-012-0132-x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,23]],"date-time":"2025-03-23T21:11:05Z","timestamp":1742764265000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10787-012-0132-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,3,23]]},"references-count":43,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2012,10]]}},"alternative-id":["132"],"URL":"https:\/\/doi.org\/10.1007\/s10787-012-0132-x","relation":{},"ISSN":["0925-4692","1568-5608"],"issn-type":[{"value":"0925-4692","type":"print"},{"value":"1568-5608","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,3,23]]}}}