{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T18:59:39Z","timestamp":1780945179657,"version":"3.54.1"},"reference-count":54,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2013,5,19]],"date-time":"2013-05-19T00:00:00Z","timestamp":1368921600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Inflammopharmacol"],"published-print":{"date-parts":[[2013,8]]},"DOI":"10.1007\/s10787-013-0173-9","type":"journal-article","created":{"date-parts":[[2013,5,18]],"date-time":"2013-05-18T21:08:41Z","timestamp":1368911321000},"page":"291-300","source":"Crossref","is-referenced-by-count":8,"title":["Conditional pharmacology\/toxicology V: ambivalent effects of thiocyanate upon the development and the inhibition of experimental arthritis in rats by aurothiomalate (Myocrysin\u00ae) and metallic silver"],"prefix":"10.1007","volume":"21","author":[{"given":"Michael","family":"Whitehouse","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Desley","family":"Butters","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barrie","family":"Vernon-Roberts","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2013,5,19]]},"reference":[{"key":"173_CR1","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1007\/s10875-010-9457-7","volume":"31","author":"S Amdekar","year":"2011","unstructured":"Amdekar S, Singh V, Singh R, Sharma P, Keshav P, Kumar A (2011) Lactobacillus Casei reduces the inflammatory joint damage associated with collagen-induced arthritis by reducing the pro-inflammatory cytokines. J Clin Immunol 31:147\u2013154","journal-title":"J Clin Immunol"},{"key":"173_CR2","doi-asserted-by":"crossref","first-page":"1964","DOI":"10.1093\/jn\/134.8.1964","volume":"134","author":"E Bahrav","year":"2004","unstructured":"Bahrav E, Mor F, Halphern M, Weinberger A (2004) Lactobacillus GG bacteria ameliorate (adjuvant) arthritis in Lewis rats. J Nutr 134:1964\u20131969","journal-title":"J Nutr"},{"key":"173_CR3","first-page":"1945","volume":"25","author":"O Bakharevski","year":"1998","unstructured":"Bakharevski O, Stein-Oakley AN, Thomson NM, Ryan PFS (1998) Collagen induced arthritis in rats. Contrasting effect of subcutaneous versus intradermal inoculation of collagen. J Rheumatol 25:1945\u20131952","journal-title":"J Rheumatol"},{"key":"173_CR4","doi-asserted-by":"crossref","first-page":"2453","DOI":"10.1016\/0006-2952(73)90348-1","volume":"22","author":"FJ Beck","year":"1973","unstructured":"Beck FJ, Whitehouse MW (1973) Effect of adjuvant disease in rats on cyclophosphamide and isophosphamide metabolism. Biochem Pharmacol 22:2453\u20132468","journal-title":"Biochem Pharmacol"},{"key":"173_CR100","doi-asserted-by":"crossref","unstructured":"Betts WM, Whitehouse MW, Cleland L, Vernon-Roberts B (1985) In vitro antioxidant properties of potential transformation products of salicylate: sulphasalazine and amidopyrine. J Free Radic Biol Med 1:273\u2013280","DOI":"10.1016\/0748-5514(85)90131-X"},{"key":"173_CR5","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1007\/s10787-007-0017-6","volume":"16","author":"CL Brown","year":"2008","unstructured":"Brown CL, Whitehouse MW, Tiekink ERT, Bushell GR (2008) Colloidal metallic gold is not bio-inert. Inflammopharmacol 16:133\u2013137","journal-title":"Inflammopharmacol"},{"key":"173_CR6","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/0003-9861(70)90108-6","volume":"141","author":"J Chung","year":"1970","unstructured":"Chung J, Wood JL (1970) Oxidation of thiocyanate to cyanide and sulphite by the lactoperoxidase\u2013hydrogen peroxide system. Arch Biochem Biophys 141:73\u201378","journal-title":"Arch Biochem Biophys"},{"key":"173_CR7","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/S0928-8244(03)00147-0","volume":"38","author":"R Clanncy","year":"2003","unstructured":"Clancy R (2003) Immunobiotics and the probiotic revolution. FEMS Immunol Med Microbiol 38(1):9\u201312","journal-title":"FEMS Immunol Med Microbiol"},{"key":"173_CR8","doi-asserted-by":"crossref","first-page":"47","DOI":"10.5530\/pc.2012.1.9","volume":"2","author":"I Cock","year":"2012","unstructured":"Cock I, Mohanty S, White A, Whitehouse M (2012) Colloidal silver (CS) as an antiseptic: two opposing viewpoints. Pharmacog Comm 2:47\u201356","journal-title":"Pharmacog Comm"},{"key":"173_CR9","first-page":"1137","volume":"17","author":"A Beaux De","year":"1990","unstructured":"De Beaux A, Keenan CM, Tytgat K, Rangachari PK (1990) Responses of the colonic epithelium to auranofin: evidence for involvement of enteric nerves. J Rheumatol 17:1137\u20131141","journal-title":"J Rheumatol"},{"key":"173_CR10","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1007\/978-0-85729-950-5","volume-title":"Rheumatoid arthritis and Proteus","author":"A Ebringer","year":"2012","unstructured":"Ebringer A (2012) Rheumatoid arthritis and Proteus. Springer, London, p 233"},{"key":"173_CR11","unstructured":"Ferraccioli G, Peri F, Nervetti A, Ambanelli, Savi M (1986) Toxicity due to remission inducing drugs in rheumatoid arthritis. Association with HLA-B35 and Cw4 antigens. J Rheumatol 13:65\u201368"},{"key":"173_CR12","volume-title":"Alexander the Great","author":"RL Fox","year":"1973","unstructured":"Fox RL (1973) Alexander the Great. Allen Lane, London"},{"key":"173_CR101","doi-asserted-by":"crossref","unstructured":"Gadd SJ, Whitehouse MW, Vernon-Roberts B (1992) Conditional pharmacology II. ambivalent effects of aurocyanide, a putative active metabolite of anti-arthritic gold drugs on human and rate PMN leukocytes. Inflammapharmacol 1:305\u2013314","DOI":"10.1007\/BF02755881"},{"key":"173_CR13","volume-title":"The pathological basis of the connective tissue diseases","year":"1992","unstructured":"Gardner DL (ed) (1992) The pathological basis of the connective tissue diseases. Edward Arnold, London"},{"key":"173_CR14","first-page":"1079","volume":"12","author":"R Garrett","year":"1985","unstructured":"Garrett R, Whitehouse MW, Vernon-Roberts B, Brooks PM (1985) Ambivalent properties of gold drugs in adjuvant-induced polyarthritis in rats. J Rheumatol 12:1079\u20131082","journal-title":"J Rheumatol"},{"key":"173_CR15","first-page":"83","volume":"6","author":"P Ghosh","year":"2008","unstructured":"Ghosh P, Shimmon S, Wilson-Ghosh N, Whitehouse M (2008) Cartilage-derived peptacans: novel nutraceuticals with immunomodulatory, anti-inflammatory and anti-arthritic activities. Curr Top Nutriceutical Res 6:83\u201398","journal-title":"Curr Top Nutriceutical Res"},{"key":"173_CR16","doi-asserted-by":"crossref","first-page":"1697","DOI":"10.1016\/0006-2952(90)90113-Y","volume":"39","author":"GG Graham","year":"1990","unstructured":"Graham GG, Dale M (1990) The activation of gold complexes by cyanide produced by polymorphonuclear leukocytes 2. Evidence for the formation and activity of aurocyanide. Biochem Pharmacol 39:1697\u20131702","journal-title":"Biochem Pharmacol"},{"key":"173_CR17","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1007\/s10787-007-0020-y","volume":"16","author":"GG Graham","year":"2008","unstructured":"Graham GG, Whitehouse MW, Bushell GR (2008) Aurocyanide, dicyano-aurate(I), a pharmacologically active metabolite of medicinal gold complexes. Inflammopharmacol 16:126\u2013132","journal-title":"Inflammopharmacol"},{"key":"173_CR18","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1136\/ard.42.1.63","volume":"42","author":"JT Gran","year":"1983","unstructured":"Gran JT, Husby G, Thorsby E (1983) HLA-DR antigens and gold toxicity. Ann Rheum Dis 42:63\u201366","journal-title":"Ann Rheum Dis"},{"key":"173_CR102","doi-asserted-by":"crossref","unstructured":"Haynes DR, Wright PFA, Gadd SJ, Whitehouse MW, Vernon-Roberts B (1993) Is aspirin a prodrug for antioxidant and cytokine-modulating oxymetabolites? Agents Actions 39:49\u201358","DOI":"10.1007\/BF01975714"},{"key":"173_CR19","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1034\/j.1600-065x.2001.1840117.x","volume":"184","author":"R Holmdahl","year":"2001","unstructured":"Holmdahl R, Lorentzen JC, Lu S, Olofsson P, Wester L, Holmberg J et al (2001) Arthritis induced in rats with non-immunogenic adjuvants as models for rheumatoid arthritis. Immunol Rev 184:184\u2013202","journal-title":"Immunol Rev"},{"key":"173_CR20","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1136\/ard.60.3.223","volume":"60","author":"D Hutchinson","year":"2001","unstructured":"Hutchinson D, Shepstone L, Moots R, Lear JT, Lynch MP (2001) Heavy cigarette smoking is strongly associated with rheumatoid arthritis (RA) particularly in patients without a history of RA. Ann Rheum Dis 60:223\u2013227","journal-title":"Ann Rheum Dis"},{"key":"173_CR21","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1002\/art.21575","volume":"54","author":"L Klareskog","year":"2006","unstructured":"Klareskog L, Stolt P, Lundberg K, Kallberg H, Bengstsson C, Grunewald J et al (2006) Smoking may trigger HLA-DR (shared epitiope)\u2014restricted immune reactions to autoantigens modified by citrullination. Arthritis Rheum 54:38\u201346","journal-title":"Arthritis Rheum"},{"key":"173_CR22","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1007\/BF02004707","volume":"11","author":"JH Leibfarth","year":"1981","unstructured":"Leibfarth JH, Persellin RH (1981) Mechanisms of action of gold. Agents Actions 11:458\u2013472","journal-title":"Agents Actions"},{"key":"173_CR23","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1002\/art.1780230809","volume":"23","author":"WJ McCune","year":"1980","unstructured":"McCune WJ, Trentham DE, David JR (1980) Gold does not alter the arthritic, humoral or cellular responses in rats with type-II collagen-induced arthritis. Arthr Rheum 23:932\u2013936","journal-title":"Arthr Rheum"},{"key":"173_CR24","first-page":"365","volume-title":"The inflammatory reaction","author":"HZ Movat","year":"1985","unstructured":"Movat HZ (1985) The inflammatory reaction. Elsevier, Amsterdam, p 365"},{"key":"173_CR25","doi-asserted-by":"crossref","first-page":"975","DOI":"10.3109\/10715762.2012.667566","volume":"46","author":"DI Pattison","year":"2012","unstructured":"Pattison DI, Davies MJ, Hawkins CL (2012) Reactions and reactivity of myeloperoxidase-derived oxidants: differential biological effects of hypochlorous and hypothiocyanous acids. Free Radic Res 46:975\u2013995","journal-title":"Free Radic Res"},{"key":"173_CR26","first-page":"579","volume":"47","author":"K Phadke","year":"1982","unstructured":"Phadke K, Carroll J, Nanda S (1982) Effects of various anti-inflammatory drugs on type II collagen-induced arthritis in rats. Clin Exp Immunol 47:579\u2013586","journal-title":"Clin Exp Immunol"},{"key":"173_CR27","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1007\/BF02668032","volume":"3","author":"MC Powanda","year":"1995","unstructured":"Powanda MC (1995) The concept of conditional pharmacology and toxicology. Inflammopharmacol 3:363\u2013371","journal-title":"Inflammopharmacol"},{"key":"173_CR103","doi-asserted-by":"crossref","unstructured":"Skaff O, Pattison DI, Davies MJ (2009) Hypothiocyanous acid reactivity with lo molecular-mass and protein thiols: absolute rate constants and assessment of biological relevance. Biochem J 422:111\u2013117","DOI":"10.1042\/BJ20090276"},{"key":"173_CR28","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1007\/s10787-997-0021-x","volume":"5","author":"JM Snowden","year":"1997","unstructured":"Snowden JM, Whitehouse MW (1997) Anti-inflammatory activity of some emu oils in rats. Inflammopharmacol 5:127\u2013132","journal-title":"Inflammopharmacol"},{"key":"173_CR104","doi-asserted-by":"crossref","unstructured":"Stelmaszynska T (1986) Formation of HCN and its chlorination to CICN by stimulated human neutropohils-2. Oxidation of thiocyanate as a source of HCN. Int J Biochem 18:1107\u20131114","DOI":"10.1016\/0020-711X(86)90084-4"},{"key":"173_CR29","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1002\/art.1780250801","volume":"25","author":"DE Trentham","year":"1982","unstructured":"Trentham DE (1982) Collagen arthritis as a relevant model for human disease. Arthr Rheum 25:911\u2013916","journal-title":"Arthr Rheum"},{"key":"173_CR105","doi-asserted-by":"crossref","unstructured":"van Dalen CJ, Whitehouse MW, Winterbourn CC, Kettle AJ (1997) Thiocyanide and chloride as competing substrates for myeloperoxidase. Biochem J 327:487\u2013492","DOI":"10.1042\/bj3270487"},{"key":"173_CR30","first-page":"363","volume-title":"State of the science literature review: everything nanosilver and more","author":"K Varner","year":"2010","unstructured":"Varner K, El-Badaway A, Feldhake D, Venkatapathy R (2010) State of the science literature review: everything nanosilver and more. US Environmental Protection Agency, Washington DC, p 363"},{"key":"173_CR31","doi-asserted-by":"crossref","first-page":"1268","DOI":"10.1038\/2221286a0","volume":"222","author":"B Vernon-Roberts","year":"1969","unstructured":"Vernon-Roberts B (1969) Lymphocyte to macrophage transformation in the peritoneal cavity preceding the mobilization of peritoneal macrophages to inflamed areas. Nature 222:1268\u20131288","journal-title":"Nature"},{"key":"173_CR106","doi-asserted-by":"crossref","unstructured":"Vernon-Roberts B (1988) Inflammation 1987: an overview. Agents Actions Suppl 24:1\u201318","DOI":"10.1007\/978-3-0348-9160-8_1"},{"key":"173_CR32","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1136\/ard.35.6.477","volume":"35","author":"B Vernon-Roberts","year":"1976","unstructured":"Vernon-Roberts B, Dore JL, Jessop JD, Henderson WJ (1976) Selective concentration and localisation of gold in macrophages of synovial and other tissues during and after chrysotherapy in rheumatoid patients. Ann Rheum Dis 35:477\u2013486","journal-title":"Ann Rheum Dis"},{"key":"173_CR33","first-page":"1755","volume":"15","author":"BA Wallin","year":"1988","unstructured":"Wallin BA, McCafferty JP, Fox MJ, Cooper Dr, Goldschmidt MS (1988) Incidence and management of diarrhea during longterm auranofin therapy. J Rheumatol 15:1755\u20131758","journal-title":"J Rheumatol"},{"key":"173_CR34","doi-asserted-by":"crossref","first-page":"1176","DOI":"10.1038\/nm1637","volume":"13","author":"Z Wang","year":"2007","unstructured":"Wang Z, Nicholls SJ, Rodrigeuz ER, Kummu O, Horkko S, Barnard J et al (2007) Protein carbamylation links inflammation, smoking, uremia and atherogenesis. Nat Med 13:1176\u20131184","journal-title":"Nat Med"},{"key":"173_CR35","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/0167-4838(82)90463-0","volume":"709","author":"R Wever","year":"1982","unstructured":"Wever R, Kast WM, Kasinoedin JH, Boelens R (1982) The peroxidation of thiocyanate catalysed by myeloperoxidase and lactoperoxidase. Biochim Biophys Acta 709:212\u2013219","journal-title":"Biochim Biophys Acta"},{"key":"173_CR36","first-page":"58","volume":"70","author":"MW Whitehouse","year":"1992","unstructured":"Whitehouse MW (1992a) Inflammatory tone: a heuristic concept for more rational therapies? Immunol Cell Biol 70:58","journal-title":"Immunol Cell Biol"},{"key":"173_CR107","doi-asserted-by":"crossref","unstructured":"Whitehouse MW (1992b) On the subject of (disease) conditioned pharmacology\/toxicology. Inflammopharmacol 1:286\u2013287","DOI":"10.1007\/BF02755878"},{"key":"173_CR37","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1007\/s00011-006-6117-8","volume":"56","author":"MW Whitehouse","year":"2007","unstructured":"Whitehouse MW (2007) Adjuvant arthritis 50\u00a0years on: the impact of the 1956 article by CM Pearson, \u2018Development of arthritis, periarthritis and periostitis in rats given adjuvants\u2019. Inflamm Res 56:133\u2013138","journal-title":"Inflamm Res"},{"key":"173_CR38","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1007\/s10787-007-0022-9","volume":"16","author":"MW Whitehouse","year":"2008","unstructured":"Whitehouse MW (2008) Therapeutic gold. Is it due for a come-back? Inflammopharmacol 16:107\u2013109","journal-title":"Inflammopharmacol"},{"key":"173_CR39","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1177\/0961203311429818","volume":"21","author":"MW Whitehouse","year":"2012","unstructured":"Whitehouse MW (2012) Oily adjuvants and autoimmunity: now time for reconsideration? Lupus 21:217\u2013222","journal-title":"Lupus"},{"key":"173_CR40","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1007\/BF02312038","volume":"45","author":"MW Whitehouse","year":"1996","unstructured":"Whitehouse MW, Graham GG (1996) Is local biotransformation the key to understanding the pharmacological activity of salicylates and gold drugs? Inflamm Res 45:579\u2013582","journal-title":"Inflamm Res"},{"key":"173_CR41","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1007\/s00011-009-0038-2","volume":"58","author":"MW Whitehouse","year":"2009","unstructured":"Whitehouse MW, Jones M (2009) Pro-inflammatory activity in rats of thiocyanate, a metabolite of the hydrocyanic acid inhaled from tobacco smoke. Inflamm Res 58:693\u2013704","journal-title":"Inflamm Res"},{"key":"173_CR42","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1007\/BF02735395","volume":"1","author":"MW Whitehouse","year":"1991","unstructured":"Whitehouse MW, Vernon-Roberts B (1991) Conditional pharmacology. Expression of anti-inflammatory activity may require pre-existent inflammatory mediators\/hormones. Inflammopharmcol 1:143\u2013149","journal-title":"Inflammopharmcol"},{"key":"173_CR45","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1155\/MBD.1998.245","volume":"5","author":"MW Whitehouse","year":"1998","unstructured":"Whitehouse MW, Cookson PD, Siasios G, Tiekink ERT (1998) Anti-arthritic activity in rats of some phosphinegold(I) thionucleobases and related thiolates. Metal- Based Drugs 5:245\u2013249","journal-title":"Metal- Based Drugs"},{"key":"173_CR46","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1007\/BF02918382","volume":"7","author":"MW Whitehouse","year":"1999","unstructured":"Whitehouse MW, Roberts MS, Brooks PM (1999) Over-the-counter (OTC) oral remedies for arthritis and rheumatism. How effective are they? Inflammopharmacol 7:89\u2013105","journal-title":"Inflammopharmacol"},{"key":"173_CR47","unstructured":"Whitehouse MW, Baharevs MA, Hancock GL, Laroo H, Nesterov VI (2012) Monitoring the anti-proteus activity of colloidal metallic silver (CMS) in vivo using the Metatron\/Hunter. In: Joint ASCEPT-APSA 2012 conference, Sydney, December 2012, Abstract 494, p 147"},{"key":"173_CR48","first-page":"1","volume":"26","author":"K Wilson","year":"1999","unstructured":"Wilson K, Goldsmith CH (1999) Does smoking cause rheumatoid arthritis? J Rheumatol 26:1\u20133","journal-title":"J Rheumatol"}],"container-title":["Inflammopharmacology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10787-013-0173-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10787-013-0173-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10787-013-0173-9","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,7,13]],"date-time":"2019-07-13T23:19:46Z","timestamp":1563059986000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10787-013-0173-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,5,19]]},"references-count":54,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2013,8]]}},"alternative-id":["173"],"URL":"https:\/\/doi.org\/10.1007\/s10787-013-0173-9","relation":{},"ISSN":["0925-4692","1568-5608"],"issn-type":[{"value":"0925-4692","type":"print"},{"value":"1568-5608","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,5,19]]}}}