{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T20:42:02Z","timestamp":1761597722198,"version":"3.37.3"},"reference-count":41,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2016,7,5]],"date-time":"2016-07-05T00:00:00Z","timestamp":1467676800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100004728","name":"VIT University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004728","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Inflammopharmacol"],"published-print":{"date-parts":[[2016,8]]},"DOI":"10.1007\/s10787-016-0273-4","type":"journal-article","created":{"date-parts":[[2016,7,5]],"date-time":"2016-07-05T05:28:27Z","timestamp":1467696507000},"page":"173-180","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Novel phenanthridine (PHE-4i) derivative inhibits carrageenan-induced rat hind paw oedema through suppression of hydrogen sulfide"],"prefix":"10.1007","volume":"24","author":[{"given":"Leema","family":"George","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tamizhselvi","family":"Ramasamy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Venkatraman","family":"Manickam","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sathiyanarayanan Kulathu","family":"Iyer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vidya","family":"Radhakrishnan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2016,7,5]]},"reference":[{"key":"273_CR1","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1016\/S0889-8529(05)70348-0","volume":"25","author":"DB Allen","year":"1996","unstructured":"Allen DB (1996) Growth suppression by glucocorticoid therapy. Endocrinol Metab Clin North Am 25:699\u2013717","journal-title":"Endocrinol Metab Clin North Am"},{"key":"273_CR2","doi-asserted-by":"publisher","first-page":"697","DOI":"10.4103\/0250-474X.84577","volume":"72","author":"P Ashok","year":"2010","unstructured":"Ashok P, Koti BC, Thippeswamy AHM et al (2010) Evaluation of anti-inflammatory activity of Centratherum anthelminticum (L) Kuntze seed. Indian J Pharm Sci 72:697\u2013703. doi: 10.4103\/0250-474X.84577","journal-title":"Indian J Pharm Sci"},{"key":"273_CR3","doi-asserted-by":"publisher","first-page":"7845","DOI":"10.1007\/s00253-013-5080-x","volume":"97","author":"A Badiei","year":"2013","unstructured":"Badiei A, Rivers-Auty J, Ang AD, Bhatia M (2013) Inhibition of hydrogen sulfide production by gene silencing attenuates inflammatory activity of LPS-activated RAW264.7 cells. Appl Microbiol Biotechnol 97:7845\u20137852. doi: 10.1007\/s00253-013-5080-x","journal-title":"Appl Microbiol Biotechnol"},{"key":"273_CR4","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/848570","author":"A Badiei","year":"2014","unstructured":"Badiei A, Muniraj N, Chambers S, Bhatia M (2014) Inhibition of hydrogen sulfide production by gene silencing attenuates inflammatory activity by downregulation of NF-\u03baB and MAP kinase activity in LPS-activated RAW 264.7 cells. Biomed Res. doi: 10.1155\/2014\/848570","journal-title":"Biomed Res"},{"key":"273_CR5","doi-asserted-by":"publisher","first-page":"6767","DOI":"10.1038\/srep06767","volume":"4","author":"LP Bai","year":"2014","unstructured":"Bai LP, Hagihara M, Nakatani K, Jiang ZH (2014) Recognition of chelerythrine to human telomeric DNA and RNA G-quadruplexes. Sci Rep 4:6767. doi: 10.1038\/srep06767","journal-title":"Sci Rep"},{"key":"273_CR6","first-page":"3312","volume":"3","author":"A Banani","year":"2012","unstructured":"Banani A, Maleki-Dizaji N, Garjani A et al (2012) Clavulanic acid exhibits anti-inflammatory effects on carrageenan-induced paw edema model of inflammation in rats. Ann Biol Res 3:3312\u20133320","journal-title":"Ann Biol Res"},{"key":"273_CR7","doi-asserted-by":"publisher","first-page":"159680","DOI":"10.6064\/2012\/159680","volume":"2012","author":"M Bhatia","year":"2012","unstructured":"Bhatia M (2012) Role of hydrogen sulfide in the pathology of inflammation. Scientifica (Cairo) 2012:159680. doi: 10.6064\/2012\/159680","journal-title":"Scientifica (Cairo)"},{"key":"273_CR8","doi-asserted-by":"publisher","first-page":"4760","DOI":"10.1073\/pnas.95.8.4760","volume":"95","author":"M Bhatia","year":"1998","unstructured":"Bhatia M, Saluja AK, Hofbauer B, et al (1998) Role of substance P and the neurokinin 1 receptor in acute pancreatitis and pancreatitis-associated lung injury. Proc Natl Acad Sci USA 95:4760\u20134765. doi: 10.1073\/pnas.95.8.4760","journal-title":"Proc Natl Acad Sci USA"},{"key":"273_CR9","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1038\/sj.bjp.0706186","volume":"145","author":"M Bhatia","year":"2005","unstructured":"Bhatia M, Sidhapuriwala J, Moochhala SM, Moore PK (2005a) Hydrogen sulphide is a mediator of carrageenan-induced hindpaw oedema in the rat. Br J Pharmacol 145:141\u2013144. doi: 10.1038\/sj.bjp.0706186","journal-title":"Br J Pharmacol"},{"key":"273_CR10","doi-asserted-by":"publisher","first-page":"623","DOI":"10.1096\/fj.04-3023fje","volume":"19","author":"M Bhatia","year":"2005","unstructured":"Bhatia M, Wong FL, Fu D et al (2005b) Role of hydrogen sulfide in acute pancreatitis and associated lung injury. FASEB J 19:623\u2013625. doi: 10.1096\/fj.04-3023fje","journal-title":"FASEB J"},{"key":"273_CR11","doi-asserted-by":"publisher","first-page":"206","DOI":"10.1111\/1523-1747.ep12506462","volume":"78","author":"PP Bradley","year":"1982","unstructured":"Bradley PP, Priebat DA, Christensen RD, Rothstein G (1982) Measurement of cutaneous inflammation: estimation of neutrophil content with an enzyme marker. J Invest Dermatol 78:206\u2013209. doi: 10.1111\/1523-1747.ep12506462","journal-title":"J Invest Dermatol"},{"key":"273_CR12","doi-asserted-by":"crossref","first-page":"30129","DOI":"10.1074\/jbc.272.48.30129","volume":"272","author":"MM Chaturvedi","year":"1997","unstructured":"Chaturvedi MM, Kumar A, Darnay BG et al (1997) Sanguinarine (pseudochelerythrine) is a potent inhibitor of NF-\u03baB activation, I\u03baB\u03b1 phosphorylation, and degradation. J Biol Chem 272:30129\u201330134","journal-title":"J Biol Chem"},{"key":"273_CR13","doi-asserted-by":"publisher","first-page":"810","DOI":"10.1016\/S0006-291X(03)00256-0","volume":"302","author":"Z Chunyu","year":"2003","unstructured":"Chunyu Z, Junbao D, Dingfang B et al (2003) The regulatory effect of hydrogen sulfide on hypoxic pulmonary hypertension in rats. Biochem Biophys Res Commun 302:810\u2013816. doi: 10.1016\/S0006-291X(03)00256-0","journal-title":"Biochem Biophys Res Commun"},{"key":"273_CR14","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1016\/j.toxlet.2013.04.020","volume":"220","author":"MH Han","year":"2013","unstructured":"Han MH, Kim GY, Yoo YH, Choi YH (2013) Sanguinarine induces apoptosis in human colorectal cancer HCT-116 cells through ROS-mediated Egr-1 activation and mitochondrial dysfunction. Toxicol Lett 220:157\u2013166. doi: 10.1016\/j.toxlet.2013.04.020","journal-title":"Toxicol Lett"},{"key":"273_CR15","first-page":"2959","volume":"5","author":"NS Karthikeyan","year":"2012","unstructured":"Karthikeyan NS, Ramachandran G, Iyer SK, Giridharan P (2012) Screening of anticancer activity and molecular modeling study of novel phenanthridine, azabicycle and cycloalkanone derivatives. J Pharm Res 5:2959\u20132964","journal-title":"J Pharm Res"},{"key":"273_CR16","doi-asserted-by":"publisher","first-page":"344","DOI":"10.1016\/0003-2697(80)90165-7","volume":"102","author":"C Labarca","year":"1980","unstructured":"Labarca C, Paigen K (1980) A simple, rapid, and sensitive DNA assay procedure. Anal Biochem 102:344\u2013352. doi: 10.1016\/0003-2697(80)90165-7","journal-title":"Anal Biochem"},{"key":"273_CR17","doi-asserted-by":"publisher","first-page":"1196","DOI":"10.1096\/fj.04-3583fje","volume":"19","author":"L Li","year":"2005","unstructured":"Li L, Bhatia M, Zhu YZ et al (2005) Hydrogen sulfide is a novel mediator of lipopolysaccharide-induced inflammation in the mouse. Faseb J 19:1196\u20131198. doi: 10.1096\/fj.04-3583fje","journal-title":"Faseb J"},{"key":"273_CR18","doi-asserted-by":"publisher","first-page":"735","DOI":"10.1124\/jpet.110.170852","volume":"335","author":"P Luo","year":"2010","unstructured":"Luo P, Wong YF, Ge L et al (2010) Anti-inflammatory and analgesic effect of plumbagin through inhibition of nuclear factor-\u03baB activation. J Pharmacol Exp Ther 335:735\u2013742. doi: 10.1124\/jpet.110.170852","journal-title":"J Pharmacol Exp Ther"},{"key":"273_CR19","doi-asserted-by":"publisher","first-page":"609","DOI":"10.1016\/j.tips.2003.10.007","volume":"24","author":"PK Moore","year":"2003","unstructured":"Moore PK, Bhatia M, Moochhala S (2003) Hydrogen sulfide: from the smell of the past to the mediator of the future? Trends Pharmacol Sci 24:609\u2013611. doi: 10.1016\/j.tips.2003.10.007","journal-title":"Trends Pharmacol Sci"},{"key":"273_CR20","doi-asserted-by":"publisher","first-page":"262","DOI":"10.1016\/j.ejphar.2012.05.039","volume":"689","author":"X Niu","year":"2012","unstructured":"Niu X, Fan T, Li W et al (2012) The anti-inflammatory effects of sanguinarine and its modulation of inflammatory mediators from peritoneal macrophages. Eur J Pharmacol 689:262\u2013269. doi: 10.1016\/j.ejphar.2012.05.039","journal-title":"Eur J Pharmacol"},{"key":"273_CR21","doi-asserted-by":"crossref","first-page":"19","DOI":"10.3121\/cmr.2007.698","volume":"5","author":"CKS Ong","year":"2007","unstructured":"Ong CKS, Lirk P, Tan CH, Seymour RA (2007) An evidence-based update on nonsteroidal anti-inflammatory drugs. Clin Med Res 5:19\u201334","journal-title":"Clin Med Res"},{"key":"273_CR22","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1038\/sj.bjp.0705650","volume":"142","author":"I Posadas","year":"2004","unstructured":"Posadas I, Bucci M, Roviezzo F et al (2004) Carrageenan-induced mouse paw oedema is biphasic, age-weight dependent and displays differential nitric oxide cyclooxygenase-2 expression. Br J Pharmacol 142:331\u2013338. doi: 10.1038\/sj.bjp.0705650","journal-title":"Br J Pharmacol"},{"key":"273_CR23","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1007\/s11101-013-9290-8","volume":"13","author":"I Slaninov\u00e1","year":"2014","unstructured":"Slaninov\u00e1 I, P\u011bn\u010d\u00edkov\u00e1 K, Urbanov\u00e1 J et al (2014) Antitumour activities of sanguinarine and related alkaloids. Phytochem Rev 13:51\u201368. doi: 10.1007\/s11101-013-9290-8","journal-title":"Phytochem Rev"},{"key":"273_CR24","doi-asserted-by":"crossref","first-page":"1619","DOI":"10.1135\/cccc19681619","volume":"33","author":"J Slavik","year":"1968","unstructured":"Slavik J, Dolejs L, Hanus V (1968) Alkaloids of Papaveraceae, Chelirubine, chelilutine, sanguirubine and sanguilutine. Mass and nuclear magnetic resonance spectra of benzo phenanthridine alkaloids. Collect Czechoslov Chem Commun 33:1619\u20131623","journal-title":"Collect Czechoslov Chem Commun"},{"key":"273_CR25","doi-asserted-by":"publisher","first-page":"917","DOI":"10.1038\/nrd2425","volume":"6","author":"C Szab\u00f3","year":"2007","unstructured":"Szab\u00f3 C (2007) Hydrogen sulphide and its therapeutic potential. Nat Rev Drug Discov 6:917\u2013935. doi: 10.1038\/nrd2425","journal-title":"Nat Rev Drug Discov"},{"key":"273_CR26","doi-asserted-by":"publisher","first-page":"e24","DOI":"10.1097\/MPA.0b013e31816857bb","volume":"36","author":"R Tamizhselvi","year":"2008","unstructured":"Tamizhselvi R, Moore PK, Bhatia M (2008) Inhibition of hydrogen sulfide synthesis attenuates chemokine production and protects mice against acute pancreatitis and associated lung injury. Pancreas 36:e24\u2013e31. doi: 10.1097\/MPA.0b013e31816857bb","journal-title":"Pancreas"},{"key":"273_CR27","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1055\/s-2001-11514","volume":"67","author":"S Tanaka","year":"2001","unstructured":"Tanaka S, Sakata Y, Morimoto K et al (2001) Influence of natural and synthetic compounds on cell surface expression of cell adhesion molecules, ICAM-1 and VCAM-1. Planta Med 67:108\u2013113","journal-title":"Planta Med"},{"key":"273_CR28","doi-asserted-by":"publisher","first-page":"2930","DOI":"10.3762\/bjoc.10.312","volume":"10","author":"LM Tumir","year":"2014","unstructured":"Tumir LM, Stojkovic MR, Piantanida I (2014) Come-back of phenanthridine and phenanthridinium derivatives in the 21st century. Beilstein J Org Chem 10:2930\u20132954. doi: 10.3762\/bjoc.10.312","journal-title":"Beilstein J Org Chem"},{"key":"273_CR29","doi-asserted-by":"publisher","first-page":"997","DOI":"10.1007\/s00216-009-2601-7","volume":"394","author":"J Urbanov\u00e1","year":"2009","unstructured":"Urbanov\u00e1 J, Lubal P, Slaninov\u00e1 I et al (2009) Fluorescence properties of selected benzo[c]phenanthridine alkaloids and studies of their interaction with CT DNA. Anal Bioanal Chem 394:997\u20131002. doi: 10.1007\/s00216-009-2601-7","journal-title":"Anal Bioanal Chem"},{"key":"273_CR30","first-page":"96","volume":"166","author":"R Vinegar","year":"1969","unstructured":"Vinegar R, Schreiber W, Hugo R (1969) Biphasic development of carrageenin edema in rats. J Pharmacol Exp Ther 166:96\u2013103","journal-title":"J Pharmacol Exp Ther"},{"key":"273_CR31","doi-asserted-by":"publisher","first-page":"19078","DOI":"10.1074\/jbc.M501467200","volume":"280","author":"A Vogt","year":"2005","unstructured":"Vogt A, Tamewitz A, Skoko J et al (2005) The benzo[c]phenanthridine alkaloid, sanguinarine, is a selective, cell-active inhibitor of mitogen-activated protein kinase phosphatase-1. J Biol Chem 280:19078\u201319086. doi: 10.1074\/jbc.M501467200","journal-title":"J Biol Chem"},{"key":"273_CR32","unstructured":"Walter LM (2009) The adrenal cortex and its disorders. In: Brook's clinical pediatric endocrinology, 6th edn. Wiley-Blackwell, Oxford, UK, pp 293\u2013351"},{"key":"273_CR33","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1006\/exmp.2001.2355","volume":"71","author":"P Weerasinghe","year":"2001","unstructured":"Weerasinghe P, Hallock S, Liepins A (2001a) Bax, Bcl-2, and NF-kappaB expression in sanguinarine induced bimodal cell death. Exp Mol Pathol 71:89\u201398. doi: 10.1006\/exmp.2001.2355","journal-title":"Exp Mol Pathol"},{"key":"273_CR34","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1023\/A:1013796432521","volume":"17","author":"P Weerasinghe","year":"2001","unstructured":"Weerasinghe P, Hallock S, Tang SC, Liepins A (2001b) Role of Bcl-2 family proteins and caspase-3 in sanguinarine-induced bimodal cell death. Cell Biol Toxicol 17:371\u2013381. doi: 10.1023\/A:1013796432521","journal-title":"Cell Biol Toxicol"},{"key":"273_CR35","doi-asserted-by":"publisher","first-page":"544","DOI":"10.3181\/00379727-111-27849","volume":"111","author":"CA Winter","year":"1962","unstructured":"Winter CA, Risley EA, Nuss GW (1962) Carrageenin-induced edema in hind paw of the rat as an assay for antiiflammatory drugs. Exp Biol Med 111:544\u2013547. doi: 10.3181\/00379727-111-27849","journal-title":"Exp Biol Med"},{"key":"273_CR36","doi-asserted-by":"crossref","first-page":"1618","DOI":"10.1093\/rheumatology\/keq045","volume":"49","author":"HL Wright","year":"2010","unstructured":"Wright HL, Moots RJ, Bucknall RC, Edwards SW (2010) Neutrophil function in inflammation and inflammatory diseases. Rheumatology 49:1618\u20131631","journal-title":"Rheumatology"},{"key":"273_CR37","first-page":"30","volume":"100","author":"A Zdarilova","year":"2006","unstructured":"Zdarilova A, Malikova J, Dvorak Z et al (2006) Quaternary isoquinoline alkaloids sanguinarine and chelerythrine. In vitro and in vivo effects. Chem List 100:30\u201341","journal-title":"Chem List"},{"key":"273_CR38","doi-asserted-by":"publisher","first-page":"L1193","DOI":"10.1152\/ajplung.00489.2005","volume":"290","author":"H Zhang","year":"2006","unstructured":"Zhang H, Zhi L, Moore PK, Bhatia M (2006) Role of hydrogen sulfide in cecal ligation and puncture-induced sepsis in the mouse. Am J Physiol Lung Cell Mol Physiol 290:L1193\u2013L1201. doi: 10.1152\/ajplung.00489.2005","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"273_CR39","doi-asserted-by":"publisher","first-page":"L960","DOI":"10.1152\/ajplung.00388.2006","volume":"292","author":"H Zhang","year":"2007","unstructured":"Zhang H, Zhi L, Moochhala S et al (2007) Hydrogen sulfide acts as an inflammatory mediator in cecal ligation and puncture-induced sepsis in mice by upregulating the production of cytokines and chemokines via NF-kappaB. Am J Physiol Lung Cell Mol Physiol 292:L960\u2013L971. doi: 10.1152\/ajplung.00388.2006","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"273_CR40","doi-asserted-by":"publisher","first-page":"417","DOI":"10.2119\/molmed.2010.00027","volume":"16","author":"J Zhang","year":"2010","unstructured":"Zhang J, Sio SW, Moochhala S, Bhatia M (2010) Role of hydrogen sulfide in severe burn injury-induced inflammation in mice. Mol Med 16:417\u2013424. doi: 10.2119\/molmed.2010.00027","journal-title":"Mol Med"},{"key":"273_CR41","doi-asserted-by":"publisher","first-page":"1322","DOI":"10.1189\/jlb.1006599","volume":"81","author":"L Zhi","year":"2007","unstructured":"Zhi L, Ang AD, Zhang H et al (2007) Hydrogen sulfide induces the synthesis of proinflammatory cytokines in human monocyte cell line U937 via the ERK-NF-kappaB pathway. J Leukoc Biol 81:1322\u20131332. doi: 10.1189\/jlb.1006599","journal-title":"J Leukoc Biol"}],"container-title":["Inflammopharmacology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10787-016-0273-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10787-016-0273-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10787-016-0273-4","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,6,24]],"date-time":"2017-06-24T13:50:18Z","timestamp":1498312218000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10787-016-0273-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,7,5]]},"references-count":41,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2016,8]]}},"alternative-id":["273"],"URL":"https:\/\/doi.org\/10.1007\/s10787-016-0273-4","relation":{},"ISSN":["0925-4692","1568-5608"],"issn-type":[{"type":"print","value":"0925-4692"},{"type":"electronic","value":"1568-5608"}],"subject":[],"published":{"date-parts":[[2016,7,5]]}}}