{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T22:57:55Z","timestamp":1780613875325,"version":"3.54.1"},"reference-count":86,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2017,6,2]],"date-time":"2017-06-02T00:00:00Z","timestamp":1496361600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Inflammopharmacol"],"published-print":{"date-parts":[[2017,8]]},"DOI":"10.1007\/s10787-017-0348-x","type":"journal-article","created":{"date-parts":[[2017,6,2]],"date-time":"2017-06-02T11:56:00Z","timestamp":1496404560000},"page":"471-484","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["Tangeretin inhibits neurodegeneration and attenuates inflammatory responses and behavioural deficits in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced Parkinson\u2019s disease dementia in rats"],"prefix":"10.1007","volume":"25","author":[{"given":"Jin-song","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-hong","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao-gang","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-song","family":"Teng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,6,2]]},"reference":[{"key":"348_CR1","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1002\/glia.20015","volume":"46","author":"C Barcia","year":"2004","unstructured":"Barcia C, Sanchez Bahillo A, Fernandez-Villalba E, Bautista V, Poza YPM, Fernandez-Barreiro A, Hirsch EC, Herrero MT (2004) Evidence of active microglia in substantia nigra pars compacta of parkinsonian monkeys 1\u00a0year after MPTP exposure. Glia 46:402\u2013409","journal-title":"Glia"},{"key":"348_CR2","doi-asserted-by":"crossref","first-page":"e565","DOI":"10.1016\/S0028-3932(02)00182-3","volume":"41","author":"J Barnes","year":"2003","unstructured":"Barnes J, Boubert L, Harris J, Lee A, David AS (2003) Reality monitoring and visual hallucinations in Parkinson\u2019s disease. Neuropsychologia 41:e565\u2013e574","journal-title":"Neuropsychologia"},{"key":"348_CR3","doi-asserted-by":"crossref","first-page":"6185","DOI":"10.1021\/jf8006568","volume":"56","author":"O Benavente-Garc\u00eda","year":"2008","unstructured":"Benavente-Garc\u00eda O, Castillo J (2008) Update on uses and properties of citrus flavonoids: new findings in anticancer, cardiovascular, and anti-inflammatory activity. J Agric Food Chem 56:6185\u20136205","journal-title":"J Agric Food Chem"},{"key":"348_CR4","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1038\/89490","volume":"4","author":"P Bezzi","year":"2001","unstructured":"Bezzi P, Domercq M, Brambilla L, Galli R, Schols D, De Clercq E, Vescovi A, Bagetta G, Kollias G, Meldolesi J, Volterra A (2001) CXCR4-activated astrocyte glutamate release via TNFalpha: amplification by microglia triggers neurotoxicity. Nat Neurosci 4:702\u2013710","journal-title":"Nat Neurosci"},{"key":"348_CR5","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/S0301-0082(99)00067-2","volume":"62","author":"F Blandini","year":"2000","unstructured":"Blandini F, Nappi G, Tassorelli C, Martignoni E (2000) Functional changes of the basal ganglia circuitry in Parkinson\u2019s disease. Prog Neurobiol 62:63\u201388","journal-title":"Prog Neurobiol"},{"key":"348_CR6","doi-asserted-by":"crossref","first-page":"e1404","DOI":"10.1212\/01.WNL.0000158422.41380.82","volume":"64","author":"H Braak","year":"2005","unstructured":"Braak H, Rub U, Jansen Steur EN, Del Tredici K, de Vos RA (2005) Cognitive status correlates with neuropathologic stage in Parkinson disease. Neurology 64:e1404\u2013e1410","journal-title":"Neurology"},{"key":"348_CR7","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.expneurol.2004.11.006","volume":"192","author":"R Braga","year":"2005","unstructured":"Braga R, Kouzmine I, Canteras NS, Da Cunha C (2005) Lesion of the substantia nigra, pars compacta impairs delayed alternation in a Y-maze in rats. Exp Neurol 192:134\u2013141","journal-title":"Exp Neurol"},{"key":"348_CR8","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.ejphar.2008.07.022","volume":"594","author":"C Capitelli","year":"2008","unstructured":"Capitelli C, Sereniki A, Lima MM, Reksidler AB, Tufik S, Vital MA (2008) Melatonin attenuates tyrosine hydroxylase loss and hypolocomotion in MPTP-lesioned rats. Eur J Pharmacol 594:101\u2013108","journal-title":"Eur J Pharmacol"},{"key":"348_CR9","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1016\/j.neuroscience.2005.03.006","volume":"133","author":"D Centonze","year":"2005","unstructured":"Centonze D, Gubellini P, Rossi S, Picconi B, Pisani A, Bernardi G, Calabresi P, Baunez C (2005) Subthalamic nucleus lesion reverses motor abnormalities and striatal glutamatergic over activity in experimental parkinsonism. Neuroscience 133:831\u2013840","journal-title":"Neuroscience"},{"key":"348_CR10","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1159\/000017294","volume":"20","author":"C Cepeda","year":"1998","unstructured":"Cepeda C, Levine MS (1998) Dopamine and N-methyl-d-aspartate receptor interactions in the neostriatum. Dev Neurosci 20:1\u201318","journal-title":"Dev Neurosci"},{"key":"348_CR11","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1006\/mgme.1997.2644","volume":"63","author":"R Chihab","year":"1998","unstructured":"Chihab R, Oillet J, Bossenmeyer C, Daval JL (1998) Glutamate triggers cell death specifically in mature central neurons through a necrotic process. Mol Genet Metab 63:142\u2013147","journal-title":"Mol Genet Metab"},{"key":"348_CR12","doi-asserted-by":"crossref","first-page":"s992","DOI":"10.2741\/1171","volume":"8","author":"GP Crucian","year":"2003","unstructured":"Crucian GP, Okun MS (2003) Visual-spatial ability in Parkinson\u2019s disease. Front Biosci 8:s992\u2013s997","journal-title":"Front Biosci"},{"key":"348_CR13","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/S0166-4328(01)00211-X","volume":"124","author":"C Cunha Da","year":"2001","unstructured":"Da Cunha C, Gevaerd MS, Vital MA, Miyoshi E, Andreatini R, Silveira R, Takahashi RN, Canteras NS (2001) Memory disruption in rats with nigral lesions induced by MPTP: a model for early Parkinson\u2019s disease amnesia. Behav Brain Res 124:9\u201318","journal-title":"Behav Brain Res"},{"key":"348_CR14","doi-asserted-by":"crossref","first-page":"3871","DOI":"10.1097\/00001756-200112040-00053","volume":"12","author":"KP Datla","year":"2001","unstructured":"Datla KP, Christidou M, Widmer WW, Rooprai HK, Dexter DT (2001) Tissue distribution and neuroprotective effects of citrus flavonoid tangeretin in a rat model of Parkinson\u2019s disease. NeuroReport 12:3871\u20133875","journal-title":"NeuroReport"},{"key":"348_CR15","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/S1474-4422(03)00351-X","volume":"2","author":"M Emre","year":"2003","unstructured":"Emre M (2003) Dementia associated with Parkinson\u2019s disease. Lancet Neurol 2:229\u2013237","journal-title":"Lancet Neurol"},{"key":"348_CR16","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/0166-4328(88)90157-X","volume":"31","author":"A Ennaceur","year":"1988","unstructured":"Ennaceur A, Delacour J (1988) A new one-trial test for neurobiological studies of memory in rats. I. Behavioral data. Behav Brain Res 31:47\u201359","journal-title":"Behav Brain Res"},{"key":"348_CR17","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.jneumeth.2005.04.005","volume":"148","author":"MM Ferro","year":"2005","unstructured":"Ferro MM, Bellissimo MI, Anselmo-Franci JA, Angellucci ME, Canteras NS, Da Cunha C (2005) Comparison of bilaterally 6-OHDA- and MPTP-lesioned rats as models of the early phase of Parkinson\u2019s disease: histological, neurochemical, motor and memory alterations. J Neurosci Meth 148:78\u201387","journal-title":"J Neurosci Meth"},{"key":"348_CR18","doi-asserted-by":"crossref","first-page":"H1320","DOI":"10.1111\/1750-3841.13300","volume":"81","author":"A Funaro","year":"2016","unstructured":"Funaro A, Wu X, Song M, Zheng J, Guo S, Rakariyatham K, Rodriguez-Estrada MT, Xiao H (2016) Enhanced anti-inflammatory activities by the combination of luteolin and tangeretin. J Food Sci 81:H1320\u2013H1327","journal-title":"J Food Sci"},{"key":"348_CR19","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/S0361-9230(01)00501-9","volume":"55","author":"MS Gevaerd","year":"2001","unstructured":"Gevaerd MS, Takahashi RN, Silveira R, Da Cunha C (2001) Caffeine reverses the memory disruption induced by intra-nigral MPTP-injection in rats. Brain Res Bull 55:101\u2013106","journal-title":"Brain Res Bull"},{"key":"348_CR20","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.bbr.2006.01.002","volume":"169","author":"PE Gilbert","year":"2006","unstructured":"Gilbert PE, Kesner RP (2006) The role of the dorsal CA3 hippocampal subregion in spatial working memory and pattern separation. Behav Brain Res 169:142\u2013149","journal-title":"Behav Brain Res"},{"key":"348_CR21","doi-asserted-by":"crossref","first-page":"1498","DOI":"10.1136\/jnnp.51.12.1498","volume":"51","author":"F Girotti","year":"1988","unstructured":"Girotti F, Soliveri P, Carella F, Piccolo I, Caffarra P, Musicco M, Caraceni T (1988) Dementia and cognitive impairment in Parkinson\u2019s disease. J Neurol Neurosurg Psychiatry 51:1498\u20131502","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"348_CR22","doi-asserted-by":"crossref","first-page":"4596","DOI":"10.1523\/JNEUROSCI.5517-03.2004","volume":"24","author":"DK Hannesson","year":"2004","unstructured":"Hannesson DK, Howland JG, Phillips AG (2004) Interaction between perirhinal and medial prefrontal cortex is required for temporal order but not recognition memory for objects in rats. J Neurosci 24:4596\u20134604","journal-title":"J Neurosci"},{"key":"348_CR23","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1016\/j.neuropharm.2007.11.010","volume":"54","author":"M Hirohata","year":"2008","unstructured":"Hirohata M, Ono K, Morinaga A, Yamada M (2008) Non-steroidal anti-inflammatory drugs have potent anti-fibrillogenic and fibril-destabilizing effects for alpha-synuclein fibrils in vitro. Neuropharmacology 54:620\u2013627","journal-title":"Neuropharmacology"},{"key":"348_CR24","doi-asserted-by":"crossref","first-page":"S9","DOI":"10.1016\/j.parkreldis.2004.10.013","volume":"11","author":"EC Hirsch","year":"2005","unstructured":"Hirsch EC, Hunot S, Hartmann A (2005) Neuroinflammatory processes in Parkinson\u2019s disease. Parkinsonism Relat Disord 11:S9\u2013S15","journal-title":"Parkinsonism Relat Disord"},{"key":"348_CR25","doi-asserted-by":"crossref","first-page":"S210","DOI":"10.1016\/S1353-8020(11)70065-7","volume":"18","author":"EC Hirsch","year":"2012","unstructured":"Hirsch EC, Vyas S, Hunot S (2012) Neuroinflammation in Parkinson\u2019s disease. Parkinsonism Relat Disord 18:S210\u2013S212","journal-title":"Parkinsonism Relat Disord"},{"key":"348_CR26","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.fct.2014.06.014","volume":"71","author":"SC Ho","year":"2014","unstructured":"Ho SC, Kuo CT (2014) Hesperidin, nobiletin, and tangeretin are collectively responsible for the anti-neuroinflammatory capacity of tangerine peel (Citri reticulatae pericarpium). Food Chem Toxicol 71:176\u2013182","journal-title":"Food Chem Toxicol"},{"key":"348_CR27","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/S0304-3940(00)01152-6","volume":"287","author":"YJ Ho","year":"2000","unstructured":"Ho YJ, Chang YC, Liu TM, Tai MY, Wong CS, Tsai YF (2000) Striatal glutamate release during novelty exposure-induced hyperactivity in olfactory bulbectomized rats. Neurosci Lett 287:117\u2013120","journal-title":"Neurosci Lett"},{"key":"348_CR28","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.bbr.2011.01.028","volume":"219","author":"YJ Ho","year":"2011","unstructured":"Ho YJ, Ho SC, Pawlak CR, Yeh KY (2011) Effects of d-cycloserine on MPTP-induced behavioral and neurological changes: potential for treatment of Parkinson\u2019s disease dementia. Behav Brain Res 219:280\u2013290","journal-title":"Behav Brain Res"},{"key":"348_CR29","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.bbr.2014.04.022","volume":"268","author":"SC Ho","year":"2014","unstructured":"Ho SC, Hsu CC, Pawlak CR, Tikhonova MA, Lai TJ, Amstislavskaya TG, Ho YJ (2014) Effects of ceftriaxone on the behavioral and neuronal changes in an MPTP-induced Parkinson\u2019s disease rat model. Behav Brain Res 268:177\u2013184","journal-title":"Behav Brain Res"},{"key":"348_CR30","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1016\/j.nlm.2008.01.003","volume":"89","author":"SK Hota","year":"2008","unstructured":"Hota SK, Barhwal K, Ray K, Singh SB, Ilavazhagan G (2008) Ceftriaxone rescues hippocampal neurons from excitotoxicity and enhances memory retrieval in chronic hypobaric hypoxia. Neurobiol Learn Mem 89:522\u2013532","journal-title":"Neurobiol Learn Mem"},{"key":"348_CR31","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.bbr.2011.12.035","volume":"229","author":"MH Hsieh","year":"2012","unstructured":"Hsieh MH, Gu SL, Ho SC, Pawlak CR, Lin CL, Ho YJ, Lai TJ, Wu FY (2012a) Effects of MK-801 on recognition and neurodegeneration in an MPTP-induced Parkinson\u2019s rat model. Behav Brain Res 229:41\u201347","journal-title":"Behav Brain Res"},{"key":"348_CR32","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.pbb.2012.03.022","volume":"102","author":"MH Hsieh","year":"2012","unstructured":"Hsieh MH, Ho SC, Yeh KY, Pawlak CR, Chang HM, Ho YJ, Lai TJ, Wu FY (2012b) Blockade of metabotropic glutamate receptors inhibits cognition and neurodegenerationin an MPTP-induced Parkinson\u2019s disease rat model. Pharmacol Biochem Behav 102:64\u201371","journal-title":"Pharmacol Biochem Behav"},{"key":"348_CR33","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.neuropharm.2014.11.023","volume":"91","author":"CY Hsu","year":"2015","unstructured":"Hsu CY, Hung CS, Chang HM, Liao WC, Ho SC, Ho YJ (2015) Ceftriaxone prevents and reverses behavioral and neuronal deficits in an MPTP-induced animal model of Parkinson\u2019s disease dementia. Neuropharmacology 91:43\u201356","journal-title":"Neuropharmacology"},{"key":"348_CR34","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1016\/j.bbr.2007.11.015","volume":"188","author":"MR Hunsaker","year":"2008","unstructured":"Hunsaker MR, Lee B, Kesner RP (2008) Evaluating the temporal context of episodic memory: the role of CA3 and CA1. Behav Brain Res 188:310\u2013315","journal-title":"Behav Brain Res"},{"key":"348_CR35","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1007\/s00401-003-0766-2","volume":"106","author":"K Imamura","year":"2003","unstructured":"Imamura K, Hishikawa N, Sawada M, Nagatsu T, Yoshida M, Hashizume Y (2003) Distribution of major histocompatibility complex class II-positive microglia and cytokine profile of Parkinson\u2019s disease brains. Acta Neuropathol 106:518\u2013526","journal-title":"Acta Neuropathol"},{"key":"348_CR36","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1007\/s00401-004-0919-y","volume":"109","author":"K Imamura","year":"2005","unstructured":"Imamura K, Hishikawa N, Ono K, Suzuki H, Sawada M, Nagatsu T, Yoshida M, Hashizume Y (2005) Cytokine production of activated microglia and decrease in neurotrophic factors of neurons in the hippocampus of Lewy body disease brains. Acta Neuropathol 109:141\u2013150","journal-title":"Acta Neuropathol"},{"key":"348_CR37","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.neuro.2011.12.019","volume":"33","author":"M Jin","year":"2012","unstructured":"Jin M, Kim BW, Koppula S, Kim IS, Park JH, Kumar H, Choi DK (2012) Molecular effects of activated BV-2 microglia by mitochondrial toxin 1-methyl- 4-phenylpyridinium. Neurotoxicology 33:147\u2013155","journal-title":"Neurotoxicology"},{"key":"348_CR38","first-page":"87","volume":"31","author":"SY Kim","year":"2013","unstructured":"Kim SY, Jones TA (2013) The effects of ceftriaxone on skill learning and motor functional outcome after ischemic cortical damage in rats. Restor Neurol Neurosci 31:87\u201397","journal-title":"Restor Neurol Neurosci"},{"key":"348_CR39","doi-asserted-by":"crossref","first-page":"355","DOI":"10.2174\/1567205054367883","volume":"2","author":"A Klegeris","year":"2005","unstructured":"Klegeris A, McGeer PL (2005) Non-steroidal anti-inflammatory drugs (NSAIDs) and other anti-inflammatory agents in the treatment of neurodegenerative disease. Curr Alzheimer Res 2:355\u2013365","journal-title":"Curr Alzheimer Res"},{"key":"348_CR40","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/S0162-3109(98)00022-8","volume":"39","author":"M Kohutnicka","year":"1998","unstructured":"Kohutnicka M, Lewandowska E, Kurkowska-Jastrzebska I, Czlonkowski A, Czlonkowska A (1998) Microglial and astrocytic involvement in a murine model of Parkinson\u2019s disease induced by 1-methyl-4-phenyl-1,2,3,6- tetrahydropyridine (MPTP). Immunopharmacology 39:167\u2013180","journal-title":"Immunopharmacology"},{"key":"348_CR42","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1002\/1531-8249(199910)46:4<598::AID-ANA7>3.0.CO;2-F","volume":"46","author":"JW Langston","year":"1999","unstructured":"Langston JW, Forno LS, Tetrud J, Reeves AG, Kaplan JA, Karluk D (1999) Evidence of active nerve cell degeneration in the substantia nigra of humans years after 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine exposure. Ann Neurol 46:598\u2013605","journal-title":"Ann Neurol"},{"key":"348_CR43","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1007\/s11481-016-9657-x","volume":"11","author":"YY Lee","year":"2016","unstructured":"Lee YY, Lee EJ, Park JS, Jang SE, Kim DH, Kim HS (2016) Anti-inflammatory and antioxidant mechanism of tangeretin in activated microglia. J Neuroimmune Pharmacol 11:294\u2013305","journal-title":"J Neuroimmune Pharmacol"},{"key":"348_CR44","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/j.nlm.2007.06.006","volume":"89","author":"JS Li","year":"2008","unstructured":"Li JS, Chao YS (2008) Electrolytic lesions of dorsal CA3 impair episodic-like memory in rats. Neurobiol Learn Mem 89:192\u2013198","journal-title":"Neurobiol Learn Mem"},{"key":"348_CR45","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1111\/aas.12018","volume":"57","author":"Y Li","year":"2013","unstructured":"Li Y, Liu C, Zhao Y, Hu K, Zhang J, Zeng M, Luo T, Jiang W, Wang H (2013) Sevoflurane induces short term changes in proteins in the cerebral cortices of developing rats. Acta Anaesthesiol Scand 57:380\u2013390","journal-title":"Acta Anaesthesiol Scand"},{"key":"348_CR46","doi-asserted-by":"crossref","first-page":"5715","DOI":"10.1523\/JNEUROSCI.20-15-05715.2000","volume":"20","author":"CM Luetjens","year":"2000","unstructured":"Luetjens CM, Bui NT, Sengpiel B, Munstermann G, Poppe M, Krohn AJ, Bauerbach E, Krieglstein J, Prehn JH (2000) Delayed mitochondrial dysfunction in excitotoxic neuron death: cytochrome c release and a secondary increase in superoxide production. J Neurosci 20:5715\u20135723","journal-title":"J Neurosci"},{"key":"348_CR47","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/j.biopha.2016.04.006","volume":"81","author":"LL Ma","year":"2016","unstructured":"Ma LL, Wang DW, Yu XD, Zhou YL (2016) Tangeretin induces cell cycle arrest and apoptosis through upregulation of PTEN expression in glioma cells. Biomed Pharmacother 81:491\u2013496","journal-title":"Biomed Pharmacother"},{"key":"348_CR48","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.1176\/ajp.152.9.1291","volume":"152","author":"CG McAllister","year":"1995","unstructured":"McAllister CG, van Kammen DP, Rehn TJ, Miller AL, Gurklis J, Kelley ME, Yao J, Peyers JL (1995) Increases in CSF levels of interleukin-2 in schizophrenia: effects of recurrence of psychosis and medication status. Am J Psychiatry 152:1291\u20131297","journal-title":"Am J Psychiatry"},{"key":"348_CR49","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.1016\/j.parkreldis.2004.01.005","volume":"10","author":"PL McGeer","year":"2004","unstructured":"McGeer PL, McGeer EG (2004) Inflammation and neurodegeneration in Parkinson\u2019s disease. Parkinsonism Relat Disord 10:S3\u2013S7","journal-title":"Parkinsonism Relat Disord"},{"key":"348_CR50","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0306-4522(98)00189-4","volume":"88","author":"CK Meshul","year":"1999","unstructured":"Meshul CK, Emre N, Nakamura CM, Allen C, Donohue MK, Buckman JF (1999) Time-dependent changes in striatal glutamate synapses following a 6-hydroxydopamine lesion. Neuroscience 88:1\u201316","journal-title":"Neuroscience"},{"key":"348_CR51","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/S0304-3940(98)00427-3","volume":"250","author":"M Mogi","year":"1998","unstructured":"Mogi M, Togari A, Ogawa M, Ikeguchi K, Shizuma N, Fan D, Nakano I, Nagatsu T (1998) Effects of repeated systemic administration of 1-methyl-4-phenyl-1,2,3,6- tetrahydropyridine (MPTP) to mice on interleukin-1beta and nerve growth factor in the striatum. Neurosci Lett 250:25\u201328","journal-title":"Neurosci Lett"},{"key":"348_CR52","doi-asserted-by":"crossref","unstructured":"More SV, Kumar H, Kim IS, Song SY, Choi DK (2013) Cellular and molecular mediators of neuroinflammation in the pathogenesis of Parkinson\u2019s disease. Mediators Inflamm 2013:952375","DOI":"10.1155\/2013\/952375"},{"key":"348_CR53","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.cnr.2006.09.006","volume":"6","author":"RL Mosley","year":"2006","unstructured":"Mosley RL, Benner EJ, Kadiu I, Thomas M, Boska MD, Hasan K, Laurie C, Gendelman HE (2006) Neuroinflammation, oxidative stress and the pathogenesis of Parkinson\u2019s disease. Clin Neurosci Res 6:261\u2013281","journal-title":"Clin Neurosci Res"},{"key":"348_CR54","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1046\/j.1460-9568.2001.01418.x","volume":"13","author":"DW Moss","year":"2001","unstructured":"Moss DW, Bates TE (2001) Activation of murine microglial cell lines by lipopolysaccharide and interferon-gamma causes NO-mediated decreases in mitochondrial and cellular function. Eur J Neurosci 13:529\u2013538","journal-title":"Eur J Neurosci"},{"key":"348_CR55","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.1002\/hipo.20122","volume":"15","author":"DG Mumby","year":"2005","unstructured":"Mumby DG, Tremblay A, Lecluse V, Lehmann H (2005) Hippocampal damage and anterograde object-recognition in rats after long retention intervals. Hippocampus 15:1050\u20131056","journal-title":"Hippocampus"},{"key":"348_CR56","doi-asserted-by":"crossref","unstructured":"Nagatsu T, Mogi M, Ichinose H, Togari A (2000) Cytokines in Parkinson\u2019s disease. J Neural Transm Suppl 58:143-151","DOI":"10.1007\/978-3-7091-6284-2_12"},{"key":"348_CR57","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.molmed.2012.12.003","volume":"19","author":"YM Nolan","year":"2013","unstructured":"Nolan YM, Sullivan AM, Toulouse A (2013) Parkinson\u2019s disease in the nuclear age of neuroinflammation. Trends Mol Med 19:187\u2013196","journal-title":"Trends Mol Med"},{"key":"348_CR58","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1007\/s12640-015-9579-z","volume":"29","author":"S Ojha","year":"2016","unstructured":"Ojha S, Javed H, Azimullah S, Abul Khair SB, Haque ME (2016) Glycyrrhizic acid attenuates neuroinflammation and oxidative stress in rotenone model of Parkinson\u2019s disease. Neurotox Res 29:275\u2013287","journal-title":"Neurotox Res"},{"key":"348_CR59","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1037\/0894-4105.9.1.126","volume":"9","author":"AM Owen","year":"1995","unstructured":"Owen AM, Sahakian BJ, Hodges JR, Summers BA, Polkey CE, Robbins TW (1995) Dopamine dependent frontostriatal planning deficits in early Parkinson\u2019s disease. Neuropsychology 9:126\u2013140","journal-title":"Neuropsychology"},{"key":"348_CR60","volume-title":"The rat brain in stereotaxic coordinates","author":"G Paxinos","year":"1986","unstructured":"Paxinos G, Watson C (1986) The rat brain in stereotaxic coordinates. Academic Press, London"},{"key":"348_CR61","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1007\/s00280-014-2629-z","volume":"75","author":"K Periyasamy","year":"2015","unstructured":"Periyasamy K, Baskaran K, Ilakkia A, Vanitha K, Selvaraj S, Sakthisekaran D (2015) Antitumor efficacy of tangeretin by targeting the oxidative stress mediated on 7,12-dimethylbenz(a) anthracene-induced proliferative breast cancer in Sprague-Dawley rats. Cancer Chemother Pharmacol 75:263\u2013272","journal-title":"Cancer Chemother Pharmacol"},{"key":"348_CR62","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1016\/j.expneurol.2005.05.009","volume":"195","author":"JC Perry","year":"2005","unstructured":"Perry JC, Hipolide DC, Tufik S, Martins RD, Da Cunha C, Andreatini R, Vital MA (2005) Intra-nigral MPTP lesion in rats: behavioral and autoradiography studies. Exp Neurol 195:322\u2013329","journal-title":"Exp Neurol"},{"key":"348_CR63","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1038\/nrneurol.2010.17","volume":"6","author":"VH Perry","year":"2010","unstructured":"Perry VH, Nicoll JA, Holmes C (2010) Microgliain neurodegenerative disease. Nat Rev Neurol 6:193\u2013201","journal-title":"Nat Rev Neurol"},{"key":"348_CR64","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1002\/(SICI)1097-4547(19990515)56:4<441::AID-JNR11>3.0.CO;2-G","volume":"56","author":"JM Petitto","year":"1999","unstructured":"Petitto JM, McNamara RK, Gendreau PL, Huang Z, Jackson AJ (1999) Impaired learning and memory and altered hippocampal neurodevelopment resulting from interleukin-2 gene deletion. J Neurosci Res 56:441\u2013446","journal-title":"J Neurosci Res"},{"key":"348_CR65","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1016\/j.neuroimage.2006.06.035","volume":"33","author":"C Piekema","year":"2006","unstructured":"Piekema C, Kessels RP, Mars RB, Petersson KM, Fernandez G (2006) The right hippocampus participates in short-term memory maintenance of object-location associations. Neuroimage 33:374\u2013382","journal-title":"Neuroimage"},{"key":"348_CR66","doi-asserted-by":"crossref","first-page":"II25","DOI":"10.1007\/PL00007757","volume":"247","author":"A Plaitakis","year":"2000","unstructured":"Plaitakis A, Shashidharan P (2000) Glutamate transport and metabolism in dopaminergic neurons of substantia nigra: implications for the pathogenesis of Parkinson\u2019s disease. J Neurol 247:II25\u2013II35","journal-title":"J Neurol"},{"key":"348_CR67","doi-asserted-by":"crossref","first-page":"e1483","DOI":"10.1002\/mds.20965","volume":"21","author":"B Ramirez-Ruiz","year":"2006","unstructured":"Ramirez-Ruiz B, Junque C, Marti MJ, Valldeoriola F, Tolosa E (2006) Neuropsychological deficits in Parkinson\u2019s disease patients with visual hallucinations. Mov Disord 21:e1483\u2013e1487","journal-title":"Mov Disord"},{"key":"348_CR68","doi-asserted-by":"crossref","first-page":"2322","DOI":"10.1523\/JNEUROSCI.3038-04.2005","volume":"25","author":"ZL Rossetti","year":"2005","unstructured":"Rossetti ZL, Carboni S (2005) Noradrenaline and dopamine elevations in the rat prefrontal cortex in spatial working memory. J Neurosci 25:2322\u20132329","journal-title":"J Neurosci"},{"key":"348_CR69","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1037\/0735-7044.102.5.748","volume":"102","author":"PR Sanberg","year":"1988","unstructured":"Sanberg PR, Bunsey MD, Giordano M, Norman AB (1988) The catalepsy test: its ups and downs. Behav Neurosci 102:748\u2013759","journal-title":"Behav Neurosci"},{"key":"348_CR70","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/S0006-8993(00)02036-9","volume":"860","author":"JS Schneider","year":"2000","unstructured":"Schneider JS, Tinker JP, VanVelson M, Giardiniere M (2000) Effects of the partial glycine agonist d-cycloserine on cognitive functioning in chronic low dose MPTP-treated monkeys. Brain Res 860:190\u2013194","journal-title":"Brain Res"},{"key":"348_CR71","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/S0304-3940(03)00172-1","volume":"341","author":"TB Sherer","year":"2003","unstructured":"Sherer TB, Betarbet R, Kim JH, Greenamyre JT (2003) Selective microglial activation in the rat rotenone model of Parkinson\u2019s disease. Neurosci Lett 341:87\u201390","journal-title":"Neurosci Lett"},{"key":"348_CR72","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1002\/glia.20233","volume":"52","author":"M Smeyne","year":"2005","unstructured":"Smeyne M, Jiao Y, Shepherd KR, Smeyne RJ (2005) Glia cell number modulates sensitivity to MPTP in mice. Glia 52:144\u2013152","journal-title":"Glia"},{"key":"348_CR73","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1096\/fj.05-5106com","volume":"20","author":"K Sriram","year":"2006","unstructured":"Sriram K, Matheson JM, Benkovic SA, Miller DB, Luster MI, O\u2019Callaghan JP (2006) Deficiency of TNF receptors suppresses microglial activation and alters the susceptibility of brain regions to MPTP-induced neurotoxicity: role of TNF-alpha. FASEB J 20:670\u2013682","journal-title":"FASEB J"},{"key":"348_CR74","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1046\/j.1460-9568.2003.02800.x","volume":"18","author":"D Stanic","year":"2003","unstructured":"Stanic D, Finkelstein DI, Bourke DW, Drago J, Horne MK (2003) Time course of striatal reinnervation following lesions of dopaminergic SNpc neurons of the rat. Eur J Neurosci 18:1175\u20131188","journal-title":"Eur J Neurosci"},{"key":"348_CR75","first-page":"41","volume":"50","author":"AG Swennes","year":"2011","unstructured":"Swennes AG, Alworth LC, Harvey SB, Jones CA, King CS, Crowell-Davis SL (2011) Human handling promotes compliant behavior in adult laboratory rabbits. J Am Assoc Lab Anim Sci 50:41\u201345","journal-title":"J Am Assoc Lab Anim Sci"},{"key":"348_CR76","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.pbb.2009.12.020","volume":"95","author":"HN Sy","year":"2010","unstructured":"Sy HN, Wu SL, Wang WF, Chen CH, Huang YT, Liou YM, Chiou CS, Pawlak CR, Ho YJ (2010) MPTP-induced dopaminergic degeneration and deficits in object recognition in rats are accompanied by neuroinflammation in the hippocampus. Pharmacol Biochem Behav 95:158\u2013165","journal-title":"Pharmacol Biochem Behav"},{"key":"348_CR77","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.ejphar.2003.10.007","volume":"482","author":"J Voss","year":"2003","unstructured":"Voss J, Sanchez C, Michelsen S, Ebert B (2003) Rotarod studies in the rat of the GABAA receptor agonist gaboxadol: lack of ethanol potentiation and benzodiazepine cross-tolerance. Eur J Pharmacol 482:215\u2013222","journal-title":"Eur J Pharmacol"},{"key":"348_CR78","doi-asserted-by":"crossref","first-page":"e319","DOI":"10.1016\/j.nbd.2008.07.015","volume":"32","author":"MG Vuckovic","year":"2008","unstructured":"Vuckovic MG, Wood RI, Holschneider DP, Abernathy A, Togasaki DM, Smith A, Petzinger GM, Jakowec MW (2008) Memory, mood, dopamine, and serotonin in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-lesioned mouse model of basal ganglia injury. Neurobiol Dis 32:e319\u2013e327","journal-title":"Neurobiol Dis"},{"key":"348_CR79","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.neures.2006.05.013","volume":"56","author":"M Wada","year":"2006","unstructured":"Wada M, Yoshimi K, Higo N, Ren YR, Mochizuki H, Mizuno Y, Kitazawa S (2006) Statistical parametric mapping of immunopositive cell density. Neurosci Res 56:96\u2013102","journal-title":"Neurosci Res"},{"key":"348_CR80","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1037\/a0017401","volume":"123","author":"WF Wang","year":"2009","unstructured":"Wang WF, Wu SL, Liou YM, Wang AL, Pawlak CR, Ho YJ (2009) MPTP lesion causes neuroinflammation and deficits in object recognition in Wistar rats. Behav Neurosci 123:1261\u20131270","journal-title":"Behav Neurosci"},{"key":"348_CR81","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.bbr.2009.11.006","volume":"208","author":"AL Wang","year":"2010","unstructured":"Wang AL, Liou YM, Pawlak CR, Ho YJ (2010) Involvement of NMDA receptors in both MPTP-induced neuroinflammation and deficits in episodic-like memory in Wistar rats. Behav Brain Res 208:38\u201346","journal-title":"Behav Brain Res"},{"key":"348_CR82","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1038\/sj.bjp.0707167","volume":"150","author":"PS Whitton","year":"2007","unstructured":"Whitton PS (2007) Inflammation as a causative factor in the aetiology of Parkinson\u2019s disease. Br J Pharmacol 150:963\u2013976","journal-title":"Br J Pharmacol"},{"key":"348_CR83","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1096\/fj.02-0314fje","volume":"17","author":"H Wilms","year":"2003","unstructured":"Wilms H, Rosenstiel P, Sievers J, Deuschl G, Zecca L, Lucius R (2003) Activation of microglia by human neuromelanin is NF-kappa B dependent and involves p38 mitogen-activated protein kinase: implications for Parkinson\u2019s disease. FASEB J 17:500\u2013502","journal-title":"FASEB J"},{"key":"348_CR84","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1002\/ptr.4745","volume":"27","author":"JJ Wu","year":"2013","unstructured":"Wu JJ, Cui Y, Yang YS, Jung SC, Hyun JW, Maeng YH, Park DB, Lee SR, Kim SJ, Eun SY (2013) Mild mitochondrial depolarization is involved in a neuroprotective mechanism of Citrus sunki peel extract. Phytother Res 27:564\u2013571","journal-title":"Phytother Res"},{"key":"348_CR85","doi-asserted-by":"crossref","first-page":"1777","DOI":"10.1016\/j.neurobiolaging.2011.03.007","volume":"33","author":"N Xiong","year":"2012","unstructured":"Xiong N, Huang J, Chen C, Zhao Y, Zhang Z, Jia M, Zhang Z, Hou L, Yang H, Cao X, Liang Z, Zhang Y, Sun S, Lin Z, Wang T (2012) Dl-3-n-butylphthalide, a natural antioxidant, protects dopamine neurons in rotenone models for Parkinson\u2019s disease. Neurobiol Aging 33:1777\u20131791","journal-title":"Neurobiol Aging"},{"key":"348_CR86","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.jneuroim.2008.08.003","volume":"204","author":"Y Yasuda","year":"2008","unstructured":"Yasuda Y, Shimoda T, Uno K, Tateishi N, Furuya S, Yagi K, Suzuki K, Fujita S (2008) The effects of MPTP on the activation of microglia\/astrocytes and cytokine\/chemokine levels in different mice strains. J Neuroimmunol 204:43\u201351","journal-title":"J Neuroimmunol"},{"key":"348_CR87","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.neuroscience.2004.05.007","volume":"127","author":"WN Zhang","year":"2004","unstructured":"Zhang WN, Pothuizen HH, Feldon J, Rawlins JN (2004) Dissociation of function within the hippocampus: effects of dorsal, ventral and complete excitotoxic hippocampal lesions on spatial navigation. Neuroscience 127:289\u2013300","journal-title":"Neuroscience"}],"container-title":["Inflammopharmacology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10787-017-0348-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10787-017-0348-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10787-017-0348-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,25]],"date-time":"2019-09-25T12:59:47Z","timestamp":1569416387000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10787-017-0348-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,6,2]]},"references-count":86,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2017,8]]}},"alternative-id":["348"],"URL":"https:\/\/doi.org\/10.1007\/s10787-017-0348-x","relation":{},"ISSN":["0925-4692","1568-5608"],"issn-type":[{"value":"0925-4692","type":"print"},{"value":"1568-5608","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,6,2]]}}}