{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,18]],"date-time":"2025-06-18T01:10:03Z","timestamp":1750209003868,"version":"3.41.0"},"reference-count":40,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2017,4,27]],"date-time":"2017-04-27T00:00:00Z","timestamp":1493251200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100003549","name":"OTKA","doi-asserted-by":"crossref","award":["K104656"],"award-info":[{"award-number":["K104656"]}],"id":[{"id":"10.13039\/501100003549","id-type":"DOI","asserted-by":"crossref"}]},{"name":"NKFI","award":["116861"],"award-info":[{"award-number":["116861"]}]},{"name":"GINOP","award":["2.3.2-15-2016-00015 I-KOM TEAMING"],"award-info":[{"award-number":["2.3.2-15-2016-00015 I-KOM TEAMING"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Inflammopharmacol"],"published-print":{"date-parts":[[2018,2]]},"DOI":"10.1007\/s10787-017-0354-z","type":"journal-article","created":{"date-parts":[[2017,4,27]],"date-time":"2017-04-27T02:52:21Z","timestamp":1493261541000},"page":"261-271","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Acetylsalicylic acid-tris-hydroxymethyl-aminomethane reduces colon mucosal damage without causing gastric side effects in a rat model of colitis"],"prefix":"10.1007","volume":"26","author":[{"given":"Gabriella","family":"Varga","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melinda","family":"Ugocsai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Petra","family":"Hartmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Norbert","family":"Lajk\u00f3","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R\u00e9ka","family":"Moln\u00e1r","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Szil\u00e1rd","family":"Sz\u0171cs","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D\u00e1vid Kursz\u00e1n","family":"J\u00e1sz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D\u00e1niel","family":"\u00c9rces","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mikl\u00f3s","family":"Ghyczy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G\u00e1bor","family":"T\u00f3th","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mih\u00e1ly","family":"Boros","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2017,4,27]]},"reference":[{"key":"354_CR1","doi-asserted-by":"crossref","first-page":"2007","DOI":"10.1023\/A:1019660526241","volume":"47","author":"CB Appleyard","year":"2002","unstructured":"Appleyard CB, Alvarez A, Percy WH (2002) Temporal changes in colonic vascular architecture and inflammatory mediator levels in animal models of colitis. Dig Dis Sci 47:2007\u20132014","journal-title":"Dig Dis Sci"},{"key":"354_CR2","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1016\/0891-5849(89)90068-3","volume":"6","author":"JS Beckman","year":"1989","unstructured":"Beckman JS, Parks DA, Pearson JD et al (1989) A sensitive fluorometric assay for measuring xanthine dehydrogenase and oxidase in tissues. Free Radic Biol Med 6:607\u2013615","journal-title":"Free Radic Biol Med"},{"key":"354_CR3","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1053\/jcgh.2003.50001","volume":"1","author":"SJ Bickston","year":"2003","unstructured":"Bickston SJ, Cominelli F (2003) Optimal dosing of 5-aminosalicylic acid: 5 decades of choosing between politicians. Clin Gastroenterol Hepatol Off Clin Pract J Am Gastroenterol Assoc 1:3\u20134. doi: 10.1053\/jcgh.2003.50001","journal-title":"Clin Gastroenterol Hepatol Off Clin Pract J Am Gastroenterol Assoc"},{"key":"354_CR4","doi-asserted-by":"publisher","first-page":"717","DOI":"10.1046\/j.1525-1497.2002.10649.x","volume":"17","author":"D Blackburn","year":"2002","unstructured":"Blackburn D, Hux J, Mamdani M (2002) Quantification of the risk of corticosteroid-induced diabetes mellitus among the elderly. J Gen Intern Med 17:717\u2013720. doi: 10.1046\/j.1525-1497.2002.10649.x","journal-title":"J Gen Intern Med"},{"key":"354_CR5","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1159\/000117791","volume":"17","author":"AM Bou-Fersen","year":"2008","unstructured":"Bou-Fersen AM, Anim JT, Khan I (2008) Experimental colitis is associated with ultrastructural changes in inflamed and uninflamed regions of the gastrointestinal tract. Med Princ Pract 17:190\u2013196. doi: 10.1159\/000117791","journal-title":"Med Princ Pract"},{"key":"354_CR6","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.clim.2009.02.006","volume":"132","author":"NA Braus","year":"2009","unstructured":"Braus NA, Elliott DE (2009) Advances in the pathogenesis and treatment of IBD. Clin Immunol 132:1\u20139. doi: 10.1016\/j.clim.2009.02.006","journal-title":"Clin Immunol"},{"key":"354_CR7","doi-asserted-by":"publisher","first-page":"1063","DOI":"10.1016\/S0969-2126(02)00810-9","volume":"10","author":"WT Desmarais","year":"2002","unstructured":"Desmarais WT, Bienvenue DL, Bzymek KP et al (2002) The 1.20\u00a0\u00c5 resolution crystal structure of the aminopeptidase from aeromonas proteolytica complexed with Tris: a tale of buffer inhibition. Structure\u00a010:1063\u20131072. doi: 10.1016\/S0969-2126(02)00810-9","journal-title":"Structure"},{"key":"354_CR8","doi-asserted-by":"publisher","first-page":"3716","DOI":"10.3748\/wjg.v20.i13.3716","volume":"20","author":"H Ding","year":"2014","unstructured":"Ding H, Liu X-C, Mei Q et al (2014) Ulcerative colitis flair induced by mesalamine suppositories hypersensitivity. World J Gastroenterol WJG 20:3716\u20133718. doi: 10.3748\/wjg.v20.i13.3716","journal-title":"World J Gastroenterol WJG"},{"key":"354_CR9","doi-asserted-by":"publisher","first-page":"358","DOI":"10.4158\/EP.12.4.358","volume":"12","author":"AC Donihi","year":"2006","unstructured":"Donihi AC, Raval D, Saul M et al (2006) Prevalence and predictors of corticosteroid-related hyperglycemia in hospitalized patients. Endocr Pract 12:358\u2013362. doi: 10.4158\/EP.12.4.358","journal-title":"Endocr Pract"},{"key":"354_CR10","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1002\/ibd.20054","volume":"13","author":"M Ferrante","year":"2007","unstructured":"Ferrante M, Vermeire S, Katsanos KH et al (2007) Predictors of early response to infliximab in patients with ulcerative colitis. Inflamm Bowel Dis 13:123\u2013128","journal-title":"Inflamm Bowel Dis"},{"key":"354_CR11","doi-asserted-by":"publisher","first-page":"212","DOI":"10.2174\/092986608783489616","volume":"15","author":"Z Ghalanbor","year":"2008","unstructured":"Ghalanbor Z, Ghaemi N, Marashi S-A et al (2008) Binding of Tris to Bacillus licheniformis??-Amylase can affect its starch hydrolysis activity. Protein Pept Lett 15:212\u2013214. doi: 10.2174\/092986608783489616","journal-title":"Protein Pept Lett"},{"key":"354_CR12","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1007\/978-3-662-04162-8_45","volume-title":"Life in the cold","author":"E Gnaiger","year":"2000","unstructured":"Gnaiger E, Kuznetsov AV, Schneeberger S et al (2000) Mitochondria in the cold. In: Heldmaier PDG, Klingenspor DM (eds) Life in the cold. Springer, Berlin, pp 431\u2013442"},{"key":"354_CR13","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1111\/j.1549-8719.1999.tb00099.x","volume":"6","author":"DN Granger","year":"1999","unstructured":"Granger DN (1999) Ischemia-reperfusion: mechanisms of microvascular dysfunction and the influence of risk factors for cardiovascular disease. Microcirculation 6:167\u2013178. doi: 10.1111\/j.1549-8719.1999.tb00099.x","journal-title":"Microcirculation"},{"key":"354_CR14","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1002\/jlb.55.5.662","volume":"55","author":"DN Granger","year":"1994","unstructured":"Granger DN, Kubes P (1994) The microcirculation and inflammation: modulation of leukocyte-endothelial cell adhesion. J Leukoc Biol 55:662\u2013675","journal-title":"J Leukoc Biol"},{"key":"354_CR15","doi-asserted-by":"publisher","first-page":"264","DOI":"10.1016\/S0196-0709(88)80035-8","volume":"9","author":"HJ Granger","year":"1988","unstructured":"Granger HJ, Schelling ME, Lewis RE et al (1988) Physiology and pathobiology of the microcirculation. Am J Otolaryngol 9:264\u2013277. doi: 10.1016\/S0196-0709(88)80035-8","journal-title":"Am J Otolaryngol"},{"key":"354_CR16","doi-asserted-by":"crossref","first-page":"31789","DOI":"10.1074\/jbc.M204450200","volume":"277","author":"A Gugliucci","year":"2002","unstructured":"Gugliucci A, Ranzato L, Scorrano L et al (2002) Mitochondria are direct targets of the lipoxygenase inhibitor MK886. A strategy for cell killing by combined treatment with MK886 and cyclooxygenase inhibitors. J Biol Chem 277:31789\u201331795","journal-title":"J Biol Chem"},{"key":"354_CR17","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1097\/MCO.0b013e32833a5107","volume":"13","author":"P-O Hasselgren","year":"2010","unstructured":"Hasselgren P-O, Alamdari N, Aversa Z et al (2010) Corticosteroids and muscle wasting: role of transcription factors, nuclear cofactors, and hyperacetylation. Curr Opin Clin Nutr Metab Care 13:423\u2013428","journal-title":"Curr Opin Clin Nutr Metab Care"},{"key":"354_CR18","doi-asserted-by":"publisher","first-page":"304","DOI":"10.1097\/01.MIB.0000160772.78951.61","volume":"11","author":"OA Hatoum","year":"2005","unstructured":"Hatoum OA, Binion DG (2005) The vasculature and inflammatory bowel disease. Contribution to pathogenesis and clinical pathology. Inflamm Bowel Dis 11:304\u2013313. doi: 10.1097\/01.MIB.0000160772.78951.61","journal-title":"Inflamm Bowel Dis"},{"key":"354_CR19","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1016\/S0016-5085(03)00699-1","volume":"125","author":"OA Hatoum","year":"2003","unstructured":"Hatoum OA, Binion DG, Otterson MF, Gutterman DD (2003) Acquired microvascular dysfunction in inflammatory bowel disease: loss of nitric oxide-mediated vasodilation. Gastroenterology 125:58\u201369. doi: 10.1016\/S0016-5085(03)00699-1","journal-title":"Gastroenterology"},{"key":"354_CR20","first-page":"303","volume":"18","author":"E Hoste","year":"2005","unstructured":"Hoste E, Colpaert K, Vanholder R et al (2005) Sodium bicarbonate versus THAM in ICU patients with mild metabolic acidosis. J Nephrol 18:303\u2013307","journal-title":"J Nephrol"},{"key":"354_CR21","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1111\/j.1474-9726.2007.00282.x","volume":"6","author":"E H\u00fctter","year":"2007","unstructured":"H\u00fctter E, Skovbro M, Lener B et al (2007) Oxidative stress and mitochondrial impairment can be separated from lipofuscin accumulation in aged human skeletal muscle. Aging Cell 6:245\u2013256. doi: 10.1111\/j.1474-9726.2007.00282.x","journal-title":"Aging Cell"},{"key":"354_CR22","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1097\/MPG.0b013e318093f4b0","volume":"46","author":"FA Jose","year":"2008","unstructured":"Jose FA, Heyman MB (2008) Extraintestinal manifestations of inflammatory bowel disease. J Pediatr Gastroenterol Nutr 46:124\u2013133. doi: 10.1097\/MPG.0b013e318093f4b0","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"354_CR23","doi-asserted-by":"publisher","first-page":"1149","DOI":"10.1164\/ajrccm.161.4.9906031","volume":"161","author":"RH Kallet","year":"2000","unstructured":"Kallet RH, Jasmer RM, Luce JM et al (2000) The treatment of acidosis in acute lung injury with Tris-hydroxymethyl aminomethane (THAM). Am J Respir Crit Care Med 161:1149\u20131153. doi: 10.1164\/ajrccm.161.4.9906031","journal-title":"Am J Respir Crit Care Med"},{"key":"354_CR24","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1620\/tjem.143.253","volume":"143","author":"J-I Kameyama","year":"1984","unstructured":"Kameyama J-I, Narui H, Inui M, Sato T (1984) Energy level in large intestinal mucosa in patients with ulcerative colitis. Tohoku J Exp Med 143:253\u2013254. doi: 10.1620\/tjem.143.253","journal-title":"Tohoku J Exp Med"},{"key":"354_CR25","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1097\/SHK.0b013e31825d1ed0","volume":"38","author":"T Kov\u00e1cs","year":"2012","unstructured":"Kov\u00e1cs T, Varga G, \u00c9rces D et al (2012) Dietary phosphatidylcholine supplementation attenuates inflammatory mucosal damage in a rat model of experimental colitis. Shock 38:177\u2013185. doi: 10.1097\/SHK.0b013e31825d1ed0","journal-title":"Shock"},{"key":"354_CR26","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1159\/000179155","volume":"16","author":"WM Kuebler","year":"1996","unstructured":"Kuebler WM, Abels C, Schuerer L, Goetz AE (1996) Measurement of neutrophil content in brain and lung tissue by a modified myeloperoxidase assay. Int J Microcirc 16:89\u201397. doi: 10.1159\/000179155","journal-title":"Int J Microcirc"},{"key":"354_CR27","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1038\/sj\/mn\/7800095","volume":"8","author":"FS Laroux","year":"2001","unstructured":"Laroux FS, Grisham MB (2001) Immunological basis of inflammatory bowel disease: role of the microcirculation. Microcirc N Y N 8:283\u2013301. doi: 10.1038\/sj\/mn\/7800095","journal-title":"Microcirc N Y N"},{"key":"354_CR28","doi-asserted-by":"publisher","first-page":"1489","DOI":"10.1016\/S0006-2952(97)00642-4","volume":"55","author":"M Madesh","year":"1998","unstructured":"Madesh M, Balasubramanian KA (1998) Inhibition by aminosalicylates of phosphatidic acid formation induced by superoxide, calcium or spermine in enterocyte mitochondria. Biochem Pharmacol 55:1489\u20131495. doi: 10.1016\/S0006-2952(97)00642-4","journal-title":"Biochem Pharmacol"},{"key":"354_CR29","doi-asserted-by":"publisher","first-page":"2051","DOI":"10.1097\/MIB.0b013e318297d741","volume":"19","author":"E Managlia","year":"2013","unstructured":"Managlia E, Katzman RB, Brown JB, Barrett TA (2013) Antioxidant properties of mesalamine in colitis inhibit phosphoinositide 3-kinase signaling in progenitor cells. Inflamm Bowel Dis 19:2051\u20132060. doi: 10.1097\/MIB.0b013e318297d741","journal-title":"Inflamm Bowel Dis"},{"issue":"Suppl 5","key":"354_CR30","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1097\/00005344-198900135-00002","volume":"13","author":"T Masaki","year":"1989","unstructured":"Masaki T (1989) The discovery, the present state, and the future prospects of endothelin. J Cardiovasc Pharmacol 13(Suppl 5):S1\u2013S4 (discussion S18)","journal-title":"J Cardiovasc Pharmacol"},{"key":"354_CR31","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1016\/S0016-5085(89)80079-4","volume":"96","author":"GP Morris","year":"1989","unstructured":"Morris GP, Beck PL, Herridge MS et al (1989) Hapten-induced model of chronic inflammation and ulceration in the rat colon. Gastroenterology 96:795\u2013803","journal-title":"Gastroenterology"},{"key":"354_CR32","doi-asserted-by":"crossref","first-page":"892","DOI":"10.1093\/clinchem\/41.6.892","volume":"41","author":"H Moshage","year":"1995","unstructured":"Moshage H, Kok B, Huizenga JR, Jansen PL (1995) Nitrite and nitrate determinations in plasma: a critical evaluation. Clin Chem 41:892\u2013896","journal-title":"Clin Chem"},{"key":"354_CR33","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1016\/S0090-9556(25)06795-9","volume":"15","author":"EJ Mroszczak","year":"1987","unstructured":"Mroszczak EJ, Lee FW, Combs D et al (1987) Ketorolac tromethamine absorption, distribution, metabolism, excretion, and pharmacokinetics in animals and humans. Drug Metab Dispos 15:618\u2013626","journal-title":"Drug Metab Dispos"},{"key":"354_CR34","doi-asserted-by":"crossref","first-page":"1743","DOI":"10.1002\/eji.1830270722","volume":"27","author":"MF Neurath","year":"1997","unstructured":"Neurath MF, Fuss I, Pasparakis M et al (1997) Predominant pathogenic role of tumor necrosis factor in experimental colitis in mice. Eur J Immunol 27:1743\u20131750","journal-title":"Eur J Immunol"},{"key":"354_CR35","doi-asserted-by":"publisher","first-page":"524","DOI":"10.1038\/327524a0","volume":"327","author":"RMJ Palmer","year":"1987","unstructured":"Palmer RMJ, Ferrige AG, Moncada S (1987) Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor. Nature 327:524\u2013526. doi: 10.1038\/327524a0","journal-title":"Nature"},{"key":"354_CR36","doi-asserted-by":"publisher","first-page":"1593","DOI":"10.1053\/j.gastro.2004.02.070","volume":"126","author":"P Rutgeerts","year":"2004","unstructured":"Rutgeerts P, van Assche G, Vermeire S (2004) Optimizing anti-TNF treatment in inflammatory bowel disease. Gastroenterology 126:1593\u20131610. doi: 10.1053\/j.gastro.2004.02.070","journal-title":"Gastroenterology"},{"key":"354_CR37","doi-asserted-by":"publisher","first-page":"2158","DOI":"10.1002\/ibd.22926","volume":"18","author":"S Santhanam","year":"2012","unstructured":"Santhanam S, Rajamanickam S, Motamarry A et al (2012) Mitochondrial electron transport chain complex dysfunction in the colonic mucosa in ulcerative colitis. Inflamm Bowel Dis 18:2158\u20132168. doi: 10.1002\/ibd.22926","journal-title":"Inflamm Bowel Dis"},{"key":"354_CR38","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1016\/S0016-5085(19)31912-2","volume":"73","author":"JG Spenney","year":"1977","unstructured":"Spenney JG, Bhown M (1977) Effect of acetylsalicylic acid on gastric mucosa. II. Mucosal ATP and phosphocreatine content, and salicylate effects on mitochondrial metabolism. Gastroenterology 73:995\u2013999","journal-title":"Gastroenterology"},{"key":"354_CR39","doi-asserted-by":"publisher","first-page":"196","DOI":"10.1016\/S1542-3565(05)00980-8","volume":"4","author":"K Takeuchi","year":"2006","unstructured":"Takeuchi K, Smale S, Premchand P et al (2006) Prevalence and mechanism of nonsteroidal anti-inflammatory drug-induced clinical relapse in patients with inflammatory bowel disease. Clin Gastroenterol Hepatol 4:196\u2013202. doi: 10.1016\/S1542-3565(05)00980-8","journal-title":"Clin Gastroenterol Hepatol"},{"key":"354_CR40","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1016\/j.ejphar.2016.04.019","volume":"781","author":"G Varga","year":"2016","unstructured":"Varga G, Lajk\u00f3 N, Ugocsai M et al (2016) Reduced mucosal side-effects of acetylsalicylic acid after conjugation with tris-hydroxymethyl-aminomethane. Synthesis and biological evaluation of a new anti-inflammatory compound. Eur J Pharmacol 781:181\u2013189. doi: 10.1016\/j.ejphar.2016.04.019","journal-title":"Eur J Pharmacol"}],"container-title":["Inflammopharmacology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10787-017-0354-z\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10787-017-0354-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10787-017-0354-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,18]],"date-time":"2025-06-18T00:42:34Z","timestamp":1750207354000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10787-017-0354-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,4,27]]},"references-count":40,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,2]]}},"alternative-id":["354"],"URL":"https:\/\/doi.org\/10.1007\/s10787-017-0354-z","relation":{},"ISSN":["0925-4692","1568-5608"],"issn-type":[{"type":"print","value":"0925-4692"},{"type":"electronic","value":"1568-5608"}],"subject":[],"published":{"date-parts":[[2017,4,27]]}}}