{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T11:40:55Z","timestamp":1759146055695,"version":"3.41.0"},"reference-count":70,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2017,5,17]],"date-time":"2017-05-17T00:00:00Z","timestamp":1494979200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100006588","name":"Ministarstvo Znanosti, Obrazovanja i Sporta","doi-asserted-by":"publisher","award":["108-1083570-3635"],"award-info":[{"award-number":["108-1083570-3635"]}],"id":[{"id":"10.13039\/501100006588","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Inflammopharmacol"],"published-print":{"date-parts":[[2017,10]]},"DOI":"10.1007\/s10787-017-0358-8","type":"journal-article","created":{"date-parts":[[2017,5,17]],"date-time":"2017-05-17T16:17:39Z","timestamp":1495037859000},"page":"511-522","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":43,"title":["Class side effects: decreased pressure in the lower oesophageal and the pyloric sphincters after the administration of dopamine antagonists, neuroleptics, anti-emetics, l-NAME, pentadecapeptide BPC 157 and l-arginine"],"prefix":"10.1007","volume":"25","author":[{"given":"Zeljka","family":"Belosic Halle","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Josipa","family":"Vlainic","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Domagoj","family":"Drmic","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dean","family":"Strinic","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kresimir","family":"Luetic","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mario","family":"Sucic","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Medvidovic-Grubisic","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatjana","family":"Pavelic Turudic","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Igor","family":"Petrovic","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sven","family":"Seiwerth","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Predrag","family":"Sikiric","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2017,5,17]]},"reference":[{"key":"358_CR1","doi-asserted-by":"crossref","first-page":"e31","DOI":"10.4088\/JCP.13078tx2c","volume":"75","author":"A Abi-Dargham","year":"2014","unstructured":"Abi-Dargham A (2014) Schizophrenia: overview and dopamine dysfunction. J Clin Psychiatry 75:e31","journal-title":"J Clin Psychiatry"},{"key":"358_CR2","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.gtc.2014.11.008","volume":"44","author":"A Acosta","year":"2015","unstructured":"Acosta A, Camilleri M (2015) Prokinetics in gastroparesis. Gastroenterol Clin North Am 44:97\u2013111","journal-title":"Gastroenterol Clin North Am"},{"key":"358_CR3","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1016\/S0016-5085(98)70540-2","volume":"114","author":"Q Aziz","year":"1998","unstructured":"Aziz Q, Thompson DG (1998) Brain-gut axis in health and disease. Gastroenterology 114:559\u2013578","journal-title":"Gastroenterology"},{"key":"358_CR4","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.regpep.2009.05.008","volume":"156","author":"D Balenovic","year":"2009","unstructured":"Balenovic D, Bencic ML, Udovicic M et al (2009) Inhibition of methyldigoxin-induced arrhythmias by pentadecapeptide BPC 157: a relation with NO-system. Regul Pept 156:83\u201389","journal-title":"Regul Pept"},{"key":"358_CR5","doi-asserted-by":"crossref","first-page":"201","DOI":"10.4172\/2155-9880.1000201","volume":"3","author":"D Balenovic","year":"2012","unstructured":"Balenovic D, Barisic I, Prkacin I et al (2012) Mortal furosemide-hypokalemia-disturbances in rats NO-system related. Shorten survival by l-NAME. Therapy benefit with BPC 157 more than with l-arginine. J Clin Exp Cardiolog 3:201","journal-title":"J Clin Exp Cardiolog"},{"key":"358_CR6","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.regpep.2012.12.007","volume":"181","author":"I Barisic","year":"2013","unstructured":"Barisic I, Balenovic D, Klicek R et al (2013) Mortal hyperkalemia disturbances in rats are NO-system related. The life saving effect of pentadecapeptide BPC 157. Regul Pept 181:50\u201366","journal-title":"Regul Pept"},{"key":"358_CR7","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.ejphar.2003.08.013","volume":"477","author":"V Bedekovic","year":"2003","unstructured":"Bedekovic V, Mise S, Anic T et al (2003) Different effect of antiulcer agents on rat cysteamine-induced duodenal ulcer after sialoadenectomy, but not gastrectomy. Eur J Pharmacol 477:73\u201380","journal-title":"Eur J Pharmacol"},{"issue":"16","key":"358_CR8","doi-asserted-by":"crossref","first-page":"1905","DOI":"10.1016\/S0024-3205(00)01025-0","volume":"68","author":"I Bilic","year":"2001","unstructured":"Bilic I, Zoricic I, Anic T et al (2001) Haloperidol-stomach lesions attenuation by pentadecapeptide BPC 157, omeprazole, bromocriptine, but not atropine, lansoprazole, pantoprazole, ranitidine, cimetidine and misoprostol in mice. Life Sci 68(16):1905\u20131912","journal-title":"Life Sci"},{"issue":"1","key":"358_CR9","first-page":"36","volume":"12","author":"A Boban-Blagaic","year":"2006","unstructured":"Boban-Blagaic A, Blagaic V, Romic Z et al (2006) The influence of gastric pentadecapeptide BPC 157 on acute and chronic ethanol administration in mice. The effect of N(G)-nitro-l-arginine methyl ester and l-arginine. Med Sci Monit 12(1):36\u201345","journal-title":"Med Sci Monit"},{"key":"358_CR10","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1124\/jpet.110.177097","volume":"338","author":"AS Braverman","year":"2011","unstructured":"Braverman AS, Vegesna AK, Miller LS et al (2011) Pharmacologic specificity of nicotinic receptor-mediated relaxation of muscarinic receptor precontracted human gastric clasp and sling muscle fibers within the gastroesophageal junction. J Pharmacol Exp Ther 338:37\u201346","journal-title":"J Pharmacol Exp Ther"},{"issue":"1\u20133","key":"358_CR11","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.ejphar.2012.11.055","volume":"701","author":"V Cesarec","year":"2013","unstructured":"Cesarec V, Becejac T, Misic M et al (2013) Pentadecapeptide BPC 157 and the esophagocutaneous fistula healing therapy. Eur J Pharmacol 701(1\u20133):203\u2013212","journal-title":"Eur J Pharmacol"},{"issue":"3","key":"358_CR12","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1152\/japplphysiol.00945.2010","volume":"110","author":"CH Chang","year":"2011","unstructured":"Chang CH, Tsai WC, Lin MS, Hsu YH, Pang JH (2011) The promoting effect of pentadecapeptide BPC 157 on tendon healing involves tendon outgrowth, cell survival, and cell migration. J Appl Physiol 110(3):774\u2013780","journal-title":"J Appl Physiol"},{"issue":"11","key":"358_CR13","doi-asserted-by":"crossref","first-page":"19066","DOI":"10.3390\/molecules191119066","volume":"19","author":"CH Chang","year":"2014","unstructured":"Chang CH, Tsai WC, Hsu YH, Pang JH (2014) Pentadecapeptide BPC 157 enhances the growth hormone receptor expression in tendon fibroblasts. Molecules 19(11):19066\u201319077","journal-title":"Molecules"},{"issue":"14","key":"358_CR14","doi-asserted-by":"crossref","first-page":"1543","DOI":"10.1016\/j.lfs.2005.07.024","volume":"78","author":"MA Costa","year":"2006","unstructured":"Costa MA, Elesgaray R, Loria A, Balaszczuk AM, Arranz C (2006) Vascular and renal effects of dopamine during extracellular volume expansion: role of nitric oxide pathway. Life Sci 78(14):1543\u20131549","journal-title":"Life Sci"},{"issue":"2","key":"358_CR15","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1007\/s10571-005-3065-8","volume":"25","author":"EA Bel Del","year":"2005","unstructured":"Del Bel EA, Guimar\u00e3es FS, Berm\u00fadez-Echeverry M et al (2005) Role of nitric oxide on motor behavior. Cell Mol Neurobiol 25(2):371\u2013392","journal-title":"Cell Mol Neurobiol"},{"key":"358_CR16","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1254\/jphs.FP0061322","volume":"104","author":"I Dobric","year":"2007","unstructured":"Dobric I, Drvis P, Petrovic I et al (2007) Prolonged esophagitis after primary dysfunction of the pyloric sphincter in the rat and therapeutic potential of the gastric pentadecapeptide BPC 157. J Pharmacol Sci 104:7\u201318","journal-title":"J Pharmacol Sci"},{"issue":"3","key":"358_CR17","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1016\/S0022-5347(25)00398-2","volume":"240","author":"G Gallagher","year":"1987","unstructured":"Gallagher G, Brown A, Szabo S (1987) Effect of dopamine-related drugs on duodenal ulcer induced by cysteamine or propionitrile: prevention and aggravation may not be mediated by gastrointestinal secretory changes in the rat. J Pharmacol Exp Ther 240(3):883\u2013889","journal-title":"J Pharmacol Exp Ther"},{"key":"358_CR18","doi-asserted-by":"crossref","first-page":"243","DOI":"10.2147\/CIA.S13109","volume":"6","author":"P Glare","year":"2011","unstructured":"Glare P, Miller J, Nikolova T, Tickoo R (2011) Treating nausea and vomiting in palliative care: a review. Clin Interv Aging 6:243\u2013259","journal-title":"Clin Interv Aging"},{"issue":"3\u20135","key":"358_CR19","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/S0928-4257(97)89478-8","volume":"91","author":"Z Grabarevic","year":"1997","unstructured":"Grabarevic Z, Tisljar M, Artukovic B et al (1997) The influence of BPC 157 on nitric oxide agonist and antagonist induced lesions in broiler chicks. J Physiol Paris 91(3\u20135):139\u2013149","journal-title":"J Physiol Paris"},{"issue":"4","key":"358_CR02","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1007\/BF01307583","volume":"37","author":"L Grande","year":"1992","unstructured":"Grande L, Lacima G, Ros E et al (1992) Lack of effect of metoclopramide and domperidone on esophageal peristalsis and esophageal acid clearance in reflux esophagitis. Digest Dis Sci 37(4):583\u2013588","journal-title":"Digest Dis Sci"},{"issue":"3","key":"358_CR20","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1007\/s00109-016-1488-y","volume":"95","author":"MJ Hsieh","year":"2017","unstructured":"Hsieh MJ, Liu HT, Wang CN et al (2017) Therapeutic potential of pro-angiogenic BPC157 is associated with VEGFR2 activation and up-regulation. J Mol Med (Berl) 95(3):323\u2013333","journal-title":"J Mol Med (Berl)"},{"key":"358_CR21","doi-asserted-by":"crossref","first-page":"2485","DOI":"10.2147\/DDDT.S82030","volume":"9","author":"T Huang","year":"2015","unstructured":"Huang T, Zhang K, Sun L et al (2015) Body protective compound-157 enhances alkali-burn wound healing in vivo and promotes proliferation, migration, and angiogenesis in vitro. Drug Des Devel Ther 9:2485\u20132499","journal-title":"Drug Des Devel Ther"},{"key":"358_CR22","first-page":"241","volume":"61","author":"S Ilic","year":"2010","unstructured":"Ilic S, Drmic D, Zarkovic K et al (2010) High hepatotoxic dose of paracetamol produces generalized convulsions and brain damage in rats. A counteraction with the stable gastric pentadecapeptide BPC 157 (PL 14736). J Physiol Pharmacol 61:241\u2013250","journal-title":"J Physiol Pharmacol"},{"key":"358_CR23","doi-asserted-by":"crossref","first-page":"93","DOI":"10.12659\/MSMBR.883828","volume":"19","author":"I Jandric","year":"2013","unstructured":"Jandric I, Vrcic H, Jandric Balen M et al (2013) Salutary effect of gastric pentadecapeptide BPC 157 in two different stress urinary incontinence models in female rats. Med Sci Monit Basic Res 19:93\u2013102","journal-title":"Med Sci Monit Basic Res"},{"key":"358_CR24","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1016\/S0006-3223(97)00277-1","volume":"43","author":"N Jelovac","year":"1998","unstructured":"Jelovac N, Sikiric P, Rucman R et al (1998) A novel pentadecapeptide, BPC 157, blocks the stereotypy produced acutely by amphetamine and the development of haloperidol-induced supersensitivity to amphetamine. Biol Psychiatry 43:511\u2013519","journal-title":"Biol Psychiatry"},{"key":"358_CR25","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/S0014-2999(99)00486-0","volume":"379","author":"N Jelovac","year":"1999","unstructured":"Jelovac N, Sikiric P, Rucman R et al (1999) Pentadecapeptide BPC 157 attenuates disturbances induced by neuroleptics: the effect on catalepsy and gastric ulcers in mice and rats. Eur J Pharmacol 379:19\u201331","journal-title":"Eur J Pharmacol"},{"key":"358_CR26","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1254\/jphs.FP0072161","volume":"108","author":"R Klicek","year":"2008","unstructured":"Klicek R, Sever M, Radic B et al (2008) Pentadecapeptide BPC 157, in clinical trials as a therapy for inflammatory bowel disease (PL14736), is effective in the healing of colocutaneous fistulas in rats: role of the nitric oxide-system. J Pharmacol Sci 108:7\u201317","journal-title":"J Pharmacol Sci"},{"key":"358_CR27","first-page":"597","volume":"64","author":"R Klicek","year":"2013","unstructured":"Klicek R, Kolenc D, Suran J et al (2013) Stable gastric pentadecapeptide BPC 157 heals cysteamine-colitis and colon\u2013colon-anastomosis and counteracts cuprizone brain injuries and motor disability. J Physiol Pharmacol 64:597\u2013612","journal-title":"J Physiol Pharmacol"},{"key":"358_CR28","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.ejphar.2015.12.016","volume":"771","author":"A Kokot","year":"2016","unstructured":"Kokot A, Zlatar M, Stupnisek M et al (2016) NO system dependence of atropine-induced mydriasis and l-NAME- and l-arginine-induced miosis: reversal by the pentadecapeptide BPC 157 in rats and guinea pigs. Eur J Pharmacol 771:211\u2013219","journal-title":"Eur J Pharmacol"},{"key":"358_CR29","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1007\/s10787-017-0330-7","volume":"25","author":"K Luetic","year":"2017","unstructured":"Luetic K, Sucic M, Vlainic J et al (2017) Cyclophosphamide induced stomach and duodenal lesions as a NO-system disturbance in rats: l-NAME, l-arginine, stable gastric pentadecapeptide BPC 157. Inflammopharmacology 25:255\u2013264","journal-title":"Inflammopharmacology"},{"key":"358_CR30","first-page":"1163","volume":"13","author":"MC Mauri","year":"2014","unstructured":"Mauri MC, Paletta S, Maffini M et al (2014) Clinical pharmacology of atypical antipsychotics: an update. EXCLI J 13:1163\u20131191","journal-title":"EXCLI J"},{"key":"358_CR01","doi-asserted-by":"crossref","first-page":"8246171","DOI":"10.1155\/2016\/8246171","volume":"2016","author":"LN Meng","year":"2016","unstructured":"Meng LN, Chen S, Chen JD, Jin HF, Lu B (2016) Effects of Transcutaneous Electrical Acustimulation on Refractory Gastroesophageal Reflux Disease. Evid Based Complement Altern Med 2016:8246171","journal-title":"Evid Based Complement Altern Med"},{"key":"358_CR31","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/S0031-6997(25)06663-3","volume":"43","author":"S Moncada","year":"1991","unstructured":"Moncada S, Palmer RMJ, Higgs EA (1991) Nitric oxide: physiology and pharmacology. Pharmacol Rev 43:109\u2013142","journal-title":"Pharmacol Rev"},{"key":"358_CR32","first-page":"CD006271","volume":"11","author":"F Murray-Brown","year":"2015","unstructured":"Murray-Brown F, Dorman S (2015) Haloperidol for the treatment of nausea and vomiting in palliative care patients. Cochrane Database Syst Rev 11:CD006271","journal-title":"Cochrane Database Syst Rev"},{"key":"358_CR33","doi-asserted-by":"crossref","first-page":"R121","DOI":"10.1152\/ajpregu.00391.2007","volume":"294","author":"M Niedringhaus","year":"2008","unstructured":"Niedringhaus M, Jackson PG, Evans SR, Verbalis JG, Gillis RA, Sahibzada N (2008) Dorsal motor nucleus of the vagus: a site for evoking simultaneous changes in crural diaphragm activity, lower esophageal sphincter pressure, and fundus tone. Am J Physiol Regul Integr Comp Physiol 294:R121\u2013R131","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"358_CR34","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/0003-2697(79)90738-3","volume":"95","author":"H Ohkawa","year":"1979","unstructured":"Ohkawa H, Ohishi N, Yagi K (1979) Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal Biochem 95:351\u2013358","journal-title":"Anal Biochem"},{"key":"358_CR35","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1016\/S0002-8223(98)00230-2","volume":"98","author":"KM Oldham","year":"1998","unstructured":"Oldham KM, Bowen PE (1998) Oxidative stress in critical care: is antioxidant supplementation beneficial? J Am Diet Assoc 98:1001\u20131008","journal-title":"J Am Diet Assoc"},{"key":"358_CR36","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1590\/S0004-28032014000200006","volume":"51","author":"MS Palheta","year":"2014","unstructured":"Palheta MS, Gra\u00e7a JR, Santos AA et al (2014) The participation of the nitrergic pathway in increased rate of transitory relaxation of lower esophageal sphincter induced by rectal distension in dogs. Arq Gastroenterol 51:102\u2013106","journal-title":"Arq Gastroenterol"},{"key":"358_CR37","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/0149-7634(86)90017-5","volume":"10","author":"WP Par\u00e9","year":"1986","unstructured":"Par\u00e9 WP, Glavin GB (1986) Restraint stress in biomedical research: a review. Neurosci Biobehav Rev 10:339\u2013370","journal-title":"Neurosci Biobehav Rev"},{"key":"358_CR38","first-page":"CD006271","volume":"2","author":"P Perkins","year":"2009","unstructured":"Perkins P, Dorman S (2009) Haloperidol for the treatment of nausea and vomiting in palliative care patients. Cochrane Database Syst Rev 2:CD006271","journal-title":"Cochrane Database Syst Rev"},{"key":"358_CR39","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1254\/jphs.FP0060070","volume":"102","author":"I Petrovic","year":"2006","unstructured":"Petrovic I, Dobric I, Drvis P et al (2006) An experimental model of prolonged esophagitis with sphincter failure in the rat and the therapeutic potential of gastric pentadecapeptide BPC 157. J Pharmacol Sci 102:269\u2013277","journal-title":"J Pharmacol Sci"},{"key":"358_CR40","first-page":"527","volume":"62","author":"I Petrovic","year":"2011","unstructured":"Petrovic I, Dobric I, Drmic D et al (2011) BPC 157 therapy to detriment sphincters failure-esophagitis-pancreatitis in rat and acute pancreatitis patients low sphincters pressure. J Physiol Pharmacol 62:527\u2013534","journal-title":"J Physiol Pharmacol"},{"issue":"Suppl 1","key":"358_CR41","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1111\/j.1365-2982.2005.00664.x","volume":"17","author":"D Ramkumar","year":"2005","unstructured":"Ramkumar D, Schulze KS (2005) The pylorus. Neurogastroenterol Motil 17(Suppl 1):22\u201330","journal-title":"Neurogastroenterol Motil"},{"key":"358_CR42","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.2174\/13816128113199990421","volume":"20","author":"S Seiwerth","year":"2014","unstructured":"Seiwerth S, Brcic L, Batelja Vuletic L et al (2014) BPC 157 and blood vessels. Curr Pharm Des 20:1121\u20131125","journal-title":"Curr Pharm Des"},{"key":"358_CR43","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/0014-2999(85)90249-3","volume":"112","author":"P Sikiric","year":"1985","unstructured":"Sikiric P, Geber J, Suchanek E et al (1985) The role of dopamine in the formation of gastric ulcers in rats. Eur J Pharmacol 112:127\u2013128","journal-title":"Eur J Pharmacol"},{"key":"358_CR44","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/0014-2999(86)90522-4","volume":"131","author":"P Sikiric","year":"1986","unstructured":"Sikiric P, Geber J, Ivanovic D et al (1986) Dopamine antagonists induce gastric lesions in rats. Eur J Pharmacol 131:105\u2013109","journal-title":"Eur J Pharmacol"},{"key":"358_CR45","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/0014-2999(87)90525-5","volume":"144","author":"P Sikiric","year":"1987","unstructured":"Sikiric P, Rotkvic I, Mise S et al (1987) The influence of dopamine agonists and antagonists on gastric lesions in mice. Eur J Pharmacol 144:237\u2013239","journal-title":"Eur J Pharmacol"},{"key":"358_CR46","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1007\/BF01297139","volume":"36","author":"P Sikiric","year":"1991","unstructured":"Sikiric P, Rotkvic I, Mise S et al (1991) Dopamine agonists prevent duodenal ulcer relapse. A comparative study with famotidine and cimetidine. Dig Dis Sci 36:905\u2013910","journal-title":"Dig Dis Sci"},{"key":"358_CR47","doi-asserted-by":"crossref","first-page":"PL291","DOI":"10.1016\/0024-3205(93)90589-U","volume":"53","author":"P Sikiric","year":"1993","unstructured":"Sikiric P, Seiwerth S, Grabarevic Z et al (1993) Hepatoprotective effect of BPC 157, a 15-amino acid peptide, on liver lesions induced by either restraint stress or bile duct and hepatic artery ligation or CCl4 administration. A comparative study with dopamine agonists and somatostatin. Life Sci 53:PL291\u2013PL296","journal-title":"Life Sci"},{"key":"358_CR48","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/S0014-2999(97)01033-9","volume":"332","author":"P Sikiric","year":"1997","unstructured":"Sikiric P, Seiwerth S, Grabarevic Z et al (1997) The influence of a novel pentadecapeptide, BPC 157, on N(G)-nitro-l-arginine methylester and l-arginine effects on stomach mucosa integrity and blood pressure. Eur J Pharmacol 332:23\u201333","journal-title":"Eur J Pharmacol"},{"key":"358_CR49","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/S0928-4257(99)00119-9","volume":"93","author":"P Sikiric","year":"1999","unstructured":"Sikiric P, Marovic A, Matoz W et al (1999) A behavioural study of the effect of pentadecapeptide BPC 157 in Parkinson\u2019s disease models in mice and gastric lesions induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydrophyridine. J Physiol Paris 93:505\u2013512","journal-title":"J Physiol Paris"},{"key":"358_CR50","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/S0928-4257(00)00147-9","volume":"94","author":"P Sikiric","year":"2000","unstructured":"Sikiric P, Separovic J, Buljat G et al (2000) Gastric mucosal lesions induced by complete dopamine system failure in rats. The effects of dopamine agents, ranitidine, atropine, omeprazole and pentadecapeptide BPC 157. J Physiol Paris 94:105\u2013110","journal-title":"J Physiol Paris"},{"key":"358_CR51","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/S0928-4257(01)00036-5","volume":"95","author":"P Sikiric","year":"2001","unstructured":"Sikiric P, Seiwerth S, Grabarevic Z et al (2001a) Cysteamine-colon and cysteamine-duodenum lesions in rats. Attenuation by gastric pentadecapeptide BPC 157, cimetidine, ranitidine, atropine, omeprazole, sulphasalazine and methylprednisolone. J Physiol Paris 95:261\u2013270","journal-title":"J Physiol Paris"},{"key":"358_CR54","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/S0928-4257(01)00039-0","volume":"95","author":"P Sikiric","year":"2001","unstructured":"Sikiric P, Seiwerth S, Aralica G et al (2001b) Therapy effect of antiulcer agents on new chronic cysteamine colon lesion in rat. J Physiol Paris 95:283\u2013288","journal-title":"J Physiol Paris"},{"key":"358_CR52","first-page":"412","volume":"23","author":"P Sikiric","year":"2002","unstructured":"Sikiric P, Jelovac N, Jelovac-Gjeldum A et al (2002) Pentadecapeptide BPC 157 attenuates chronic amphetamine-induced behavior disturbances. Acta Pharmacol Sin 23:412\u2013422","journal-title":"Acta Pharmacol Sin"},{"key":"358_CR53","doi-asserted-by":"crossref","first-page":"1224","DOI":"10.2174\/138161210790945977","volume":"16","author":"P Sikiric","year":"2010","unstructured":"Sikiric P, Seiwerth S, Brcic L et al (2010) Revised Robert\u2019s cytoprotection and adaptive cytoprotection and stable gastric pentadecapeptide BPC 157. Possible significance and implications for novel mediator. Curr Pharm Des 16:1224\u20131234","journal-title":"Curr Pharm Des"},{"key":"358_CR55","doi-asserted-by":"crossref","first-page":"1612","DOI":"10.2174\/138161211796196954","volume":"17","author":"P Sikiric","year":"2011","unstructured":"Sikiric P, Seiwerth S, Rucman R et al (2011) Stable gastric pentadecapeptide BPC 157: novel therapy in gastrointestinal tract. Curr Pharm Des 17:1612\u20131632","journal-title":"Curr Pharm Des"},{"key":"358_CR56","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.2174\/13816128113190990411","volume":"20","author":"P Sikiric","year":"2014","unstructured":"Sikiric P, Seiwerth S, Rucman R et al (2014) Stable gastric pentadecapeptide BPC 157-NO-system relation. Curr Pharm Des 20:1126\u20131135","journal-title":"Curr Pharm Des"},{"issue":"8","key":"358_CR57","doi-asserted-by":"crossref","first-page":"857","DOI":"10.2174\/1570159X13666160502153022","volume":"14","author":"P Sikiric","year":"2016","unstructured":"Sikiric P, Seiwerth S, Rucman R et al (2016) Brain-gut axis and pentadecapeptide BPC 157. Theoretical and practical implications. Curr Neuropharmacol 14(8):857\u2013865","journal-title":"Curr Neuropharmacol"},{"key":"358_CR58","doi-asserted-by":"publisher","DOI":"10.2174\/1381612823666170220163219","author":"P Sikiric","year":"2017","unstructured":"Sikiric P, Seiwerth S, Rucman R et al (2017) Stress in gastrointestinal tract and stable gastric pentadecapeptide BPC 157. Finally, do we have a solution? Curr Pharm Des. doi: 10.2174\/1381612823666170220163219","journal-title":"Curr Pharm Des"},{"key":"358_CR59","doi-asserted-by":"crossref","first-page":"1258","DOI":"10.1053\/j.gastro.2008.06.039","volume":"135","author":"DV Sivarao","year":"2008","unstructured":"Sivarao DV, Mashimo H, Goyal RK (2008) Pyloric sphincter dysfunction in nNOS-\/- and W\/Wv mutant mice: animal models of gastroparesis and duodenogastric reflux. Gastroenterology 135:1258\u20131266","journal-title":"Gastroenterology"},{"key":"358_CR60","first-page":"581","volume":"66","author":"S Skorjanec","year":"2015","unstructured":"Skorjanec S, Kokot A, Drmic D et al (2015) Duodenocutaneous fistula in rats as a model for \u201cwound healing-therapy\u201d in ulcer healing: the effect of pentadecapeptide BPC 157, L-nitro-arginine methyl ester and l-arginine. J Physiol Pharmacol 66:581\u2013590","journal-title":"J Physiol Pharmacol"},{"issue":"4","key":"358_CR61","doi-asserted-by":"crossref","first-page":"e0123454","DOI":"10.1371\/journal.pone.0123454","volume":"10","author":"M Stupnisek","year":"2015","unstructured":"Stupnisek M, Kokot A, Drmic D et al (2015) Pentadecapeptide BPC 157 reduces bleeding and thrombocytopenia after amputation in rats treated with heparin, warfarin l-NAME and l-arginine. PLoS ONE 10(4):e0123454","journal-title":"PLoS ONE"},{"key":"358_CR62","first-page":"175","volume-title":"Dopamine Receptors, ACS Symposium Series 224","author":"S Szabo","year":"1983","unstructured":"Szabo S, Neumeyer JL (1983) Dopamine agonists and antagonists in duodenal ulcer disease. In: Kaiser C, Kebabian JW (eds) Dopamine Receptors, ACS Symposium Series 224. Am Chem Soc Publ, Washington, pp 175\u2013196"},{"key":"358_CR63","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1016\/S0022-5347(25)00396-9","volume":"240","author":"S Szabo","year":"1987","unstructured":"Szabo S, Horner HC, Maull H, Schnoor J, Chiueh CC, Palkovits M (1987) Biochemical changes in tissue catecholamines and serotonin in duodenal ulceration caused by cysteamine or propionitrile in the rat. J Pharmacol Exp Ther 240:871\u2013878","journal-title":"J Pharmacol Exp Ther"},{"key":"358_CR64","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/j.ejphar.2007.05.072","volume":"570","author":"VI Tkalcevic","year":"2007","unstructured":"Tkalcevic VI, Cuzic S, Brajsa K et al (2007) Enhancement by PL 14736 of granulation and collagen organization in healing wounds and the potential role of egr-1 expression. Eur J Pharmacol 570:212\u2013221","journal-title":"Eur J Pharmacol"},{"key":"358_CR65","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/j.lfs.2004.08.010","volume":"76","author":"Y Tohyama","year":"2004","unstructured":"Tohyama Y, Sikiri\u0107 P, Diksic M (2004) Effects of pentadecapeptide BPC157 on regional serotonin synthesis in the rat brain: alpha-methyl-l-tryptophan autoradiographic measurements. Life Sci 76:345\u2013357","journal-title":"Life Sci"},{"key":"358_CR66","first-page":"287","volume":"126","author":"B Turkovic","year":"2004","unstructured":"Turkovic B, Sikiric P, Seiwerth S et al (2004) Stable gastric pentadecapeptide BPC 157 studied for inflammatory bowel (PLD-116, PL14736, Pliva) induces nitric oxide synthesis. Gastroenterology 126:287","journal-title":"Gastroenterology"},{"key":"358_CR67","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1111\/j.1749-6632.1992.tb39755.x","volume":"664","author":"BJR Whittle","year":"1992","unstructured":"Whittle BJR, Boughton-Smith NK, Moncada S (1992) Biosynthesis and role of the endothelium-derived vasodilator, nitric oxide in gastric mucosa. Ann NY Acad Sci 664:126\u2013139","journal-title":"Ann NY Acad Sci"},{"key":"358_CR68","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1007\/s10787-015-0249-9","volume":"23","author":"M Zemba","year":"2015","unstructured":"Zemba M, Cilic AZ, Balenovic I et al (2015) BPC 157 antagonized the general anaesthetic potency of thiopental and reduced prolongation of anaesthesia induced by l-NAME\/thiopental combination. Inflammopharmacology 23:329\u2013336","journal-title":"Inflammopharmacology"}],"container-title":["Inflammopharmacology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10787-017-0358-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10787-017-0358-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10787-017-0358-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,18]],"date-time":"2025-06-18T17:30:25Z","timestamp":1750267825000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10787-017-0358-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,5,17]]},"references-count":70,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2017,10]]}},"alternative-id":["358"],"URL":"https:\/\/doi.org\/10.1007\/s10787-017-0358-8","relation":{},"ISSN":["0925-4692","1568-5608"],"issn-type":[{"type":"print","value":"0925-4692"},{"type":"electronic","value":"1568-5608"}],"subject":[],"published":{"date-parts":[[2017,5,17]]}}}