{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T04:53:09Z","timestamp":1784263989008,"version":"3.55.0"},"reference-count":70,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2017,10,23]],"date-time":"2017-10-23T00:00:00Z","timestamp":1508716800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100001843","name":"Science and Engineering Research Board","doi-asserted-by":"publisher","award":["SB\/FT\/LS-269\/2012"],"award-info":[{"award-number":["SB\/FT\/LS-269\/2012"]}],"id":[{"id":"10.13039\/501100001843","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Inflammopharmacol"],"published-print":{"date-parts":[[2018,2]]},"DOI":"10.1007\/s10787-017-0403-7","type":"journal-article","created":{"date-parts":[[2017,10,23]],"date-time":"2017-10-23T23:31:09Z","timestamp":1508801469000},"page":"235-250","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Attenuation of nociceptive pain and inflammatory disorders by total steroid and terpenoid fraction of Euphorbia tirucalli Linn root in experimental in vitro and in vivo model"],"prefix":"10.1007","volume":"26","author":[{"given":"Partha","family":"Palit","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dhrubojyoti","family":"Mukherjee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Poulami","family":"Mahanta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Md","family":"Shadab","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nahid","family":"Ali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shubhadeep","family":"Roychoudhury","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Md.","family":"Asad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Subhash C.","family":"Mandal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,10,23]]},"reference":[{"issue":"11","key":"403_CR1","doi-asserted-by":"crossref","first-page":"2672","DOI":"10.1172\/JCI118717","volume":"97","author":"GD Anderson","year":"1996","unstructured":"Anderson GD, Hauser SD, McGarity KL, Bremer ME, Isakson PC, Gregory SA (1996) Selective inhibition of cyclooxygenase (COX)-2 reverses inflammation and expression of COX-2 and interleukin 6 in rat adjuvant arthritis. J Clin Investig 97(11):2672","journal-title":"J Clin Investig"},{"issue":"2","key":"403_CR2","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1006\/bbrc.1995.1378","volume":"208","author":"S Arias-Negrete","year":"1995","unstructured":"Arias-Negrete S, Keller K, Chadee K (1995) Proinflammatory cytokines regulate cyclooxygenase-2 mRNA expression in human macrophages. Biochem Biophys Res Commun 208(2):582\u2013589","journal-title":"Biochem Biophys Res Commun"},{"issue":"1","key":"403_CR3","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.jep.2006.09.021","volume":"110","author":"S Bani","year":"2007","unstructured":"Bani S, Kaul A, Khan B, Gupta VK, Satti NK, Suri KA et al (2007) Anti-arthritic activity of a biopolymeric fraction from Euphorbia tirucalli. J Ethnopharmacol 110(1):92\u201398","journal-title":"J Ethnopharmacol"},{"issue":"6","key":"403_CR4","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1042\/cs0940557","volume":"94","author":"PJ Barnes","year":"1998","unstructured":"Barnes PJ (1998) Anti-inflammatory actions of glucocorticoids: molecular mechanisms. Clin Sci (Lond) 94(6):557\u2013572","journal-title":"Clin Sci (Lond)"},{"issue":"9","key":"403_CR5","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1089\/jir.2010.0148","volume":"31","author":"H Belguendouz","year":"2011","unstructured":"Belguendouz H, Messaoud\u00e8ne D, Lahmar K, Ahmedi L, Medjeber O, Hartani D et al (2011) Interferon-\u03b3 and nitric oxide production during Beh\u00e7et uveitis: immunomodulatory effect of interleukin-10. J Interferon Cytokine Res 31(9):643\u2013651","journal-title":"J Interferon Cytokine Res"},{"issue":"4","key":"403_CR6","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1590\/S0074-02762002000400017","volume":"97","author":"LA Betancur-Galvis","year":"2002","unstructured":"Betancur-Galvis LA, Morales GE, Forero JE, Roldan J (2002) Cytotoxic and antiviral activities of Colombian medicinal plant extracts of the Euphorbia genus. Mem\u00f3rias do Instituto Oswaldo Cruz 97(4):541\u2013546","journal-title":"Mem\u00f3rias do Instituto Oswaldo Cruz"},{"issue":"5","key":"403_CR7","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1165\/ajrcmb.10.5.8179909","volume":"10","author":"P Bradding","year":"1994","unstructured":"Bradding P, Roberts JA, Britten KM, Montefort S, Djukanovic R, Mueller R (1994) Interleukin-4, -5, and -6 and tumor necrosis factor-alpha in normal and asthmatic airways: evidence for the human mast cell as a source of these cytokines. Am J Respir Cell Mol Biol 10(5):471\u2013480","journal-title":"Am J Respir Cell Mol Biol"},{"key":"403_CR8","doi-asserted-by":"crossref","first-page":"225","DOI":"10.3181\/00379727-128-32984","volume":"128","author":"JH Brown","year":"1968","unstructured":"Brown JH, Mackey HK (1968) Inhibition of heat-induced denaturation of serum proteins by mixtures of non-steroidal anti-inflammatory agents and amino acids. Proc Soc Exp Biol Med 128:225\u2013228","journal-title":"Proc Soc Exp Biol Med"},{"key":"403_CR9","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1002\/art.22312","volume":"56","author":"N Busso","year":"2001","unstructured":"Busso N, Frasnelli M, Feifel R, Cenni B, Steinhoff M, Hamilton J (2001) Evaluation of protease-activated receptor 2 in murine models of arthritis. Arthritis Rheum 56:101\u2013107","journal-title":"Arthritis Rheum"},{"issue":"1","key":"403_CR10","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.neuron.2006.09.021","volume":"52","author":"JN Campbell","year":"2006","unstructured":"Campbell JN, Meyer RA (2006) Mechanisms of neuropathic pain. Neuron 52(1):77\u201392","journal-title":"Neuron"},{"key":"403_CR11","first-page":"152","volume":"11","author":"CT Chou","year":"1997","unstructured":"Chou CT (1997) the anti-inflammatory effect of Tripterygium wilfordii Hook F on adjuvant-induced paw edema in rats and inflammatory mediators release Phytother. Res 11:152\u2013154","journal-title":"Res"},{"key":"403_CR12","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1111\/j.1476-5381.1968.tb00973.x","volume":"32","author":"HDJ Collier","year":"1968","unstructured":"Collier HDJ, Dinnin LC, Johnson CA, Schneider C (1968) The abdominal response and its suppression by analgesic drugs in the mouse. Br J Pharmacol Chemother 32:295\u2013310","journal-title":"Br J Pharmacol Chemother"},{"key":"403_CR13","first-page":"15","volume":"49","author":"LJ Crofford","year":"1997","unstructured":"Crofford LJ (1997) COX-1 and COX-2 tissue expression: implications and predictions. J Rheumatol Suppl 49:15\u201319","journal-title":"J Rheumatol Suppl"},{"key":"403_CR14","first-page":"33","volume":"4","author":"SM Dhonde","year":"2008","unstructured":"Dhonde SM, Siraskar BD, Burande MD, Kulkarni AV, Kulkarni AS, Bingl SS (2008) Anti asthmatic activity of ethanolic extract of stem bark of Bauhinia variegata Linn. Adv Pharmacol Toxicol 4:33\u201335","journal-title":"Adv Pharmacol Toxicol"},{"issue":"7","key":"403_CR15","doi-asserted-by":"crossref","first-page":"2407","DOI":"10.4049\/jimmunol.141.7.2407","volume":"141","author":"AH Ding","year":"1988","unstructured":"Ding AH, Nathan CF, Stuehr DJ (1988) Release of reactive nitrogen intermediates and reactive oxygen intermediates from mouse peritoneal macrophages. Comparison of activating cytokines and evidence for independent production. J Immunol 141(7):2407\u20132412","journal-title":"J Immunol"},{"issue":"11","key":"403_CR16","doi-asserted-by":"crossref","first-page":"e27122","DOI":"10.1371\/journal.pone.0027122","volume":"6","author":"RC Dutra","year":"2011","unstructured":"Dutra RC, Claudino RF, Bento AF et al (2011) Preventive and therapeutic euphol treatment attenuates experimental colitis in mice. PLoS One 6(11):e27122","journal-title":"PLoS One"},{"key":"403_CR17","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1196\/annals.1397.044","volume":"1095","author":"R Enomoto","year":"2007","unstructured":"Enomoto R, Suzuki C, Koshiba C, Nishino T, Nakayama M, Hirano H (2007) Wogonin prevents immunosuppressive action but not anti-inflammatory effect induced by glucocorticoid. Ann N Y Acad Sci 1095:412\u2013417","journal-title":"Ann N Y Acad Sci"},{"issue":"1","key":"403_CR18","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1186\/s12906-016-1115-z","volume":"16","author":"GB Franco-Salla","year":"2016","unstructured":"Franco-Salla GB, Prates J, Cardin LT, dos Santos AR et al (2016) Euphorbia tirucalli modulates gene expression in larynx squamous cell carcinoma. BMC Complement Altern Med 16(1):136","journal-title":"BMC Complement Altern Med"},{"issue":"7","key":"403_CR19","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1016\/S0753-3322(03)00095-7","volume":"57","author":"L Ganju","year":"2003","unstructured":"Ganju L, Karan D, Chanda S, Srivastava KK, Sawhney RC, Selvamurthy W (2003) Immunomodulatory effects of agents of plant origin. Biomed Pharmacother 57(7):296\u2013300","journal-title":"Biomed Pharmacother"},{"key":"403_CR20","unstructured":"Gibriella HS, Ameenah GP-11(1) (2008) Medicinal Plants Prota Foundations Wageningen, pp 296\u2013301"},{"issue":"3","key":"403_CR21","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1016\/0006-2952(70)90234-0","volume":"19","author":"NH Grant","year":"1970","unstructured":"Grant NH, Alburn HE, Kryzanauskas C (1970) Stabilization of serum albumin by anti-inflammatory drugs. Biochem Pharmacol 19(3):715\u2013722","journal-title":"Biochem Pharmacol"},{"key":"403_CR22","volume-title":"Phytochemical methods a guide to modern techniques of plant analysis","author":"AJ Harborne","year":"1998","unstructured":"Harborne AJ (1998) Phytochemical methods a guide to modern techniques of plant analysis. Springer, Berlin"},{"issue":"3","key":"403_CR23","doi-asserted-by":"crossref","first-page":"1776","DOI":"10.1074\/jbc.274.3.1776","volume":"274","author":"FJ Hughes","year":"1999","unstructured":"Hughes FJ, Buttery LD, Hukkanen MV, O\u2019Donnell A, Maclouf J, Polak JM (1999) Cytokine-induced prostaglandin E2 synthesis and cyclooxygenase-2 activity are regulated both by a nitric oxide-dependent and -independent mechanism in rat osteoblasts in vitro. J Biol Chem 274(3):1776\u20131782","journal-title":"J Biol Chem"},{"issue":"11","key":"403_CR24","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1136\/thorax.55.11.925","volume":"55","author":"A Huntley","year":"2000","unstructured":"Huntley A, Ernst E (2000) Herbal medicines for asthma: a systematic review. Thorax 55(11):925\u2013929","journal-title":"Thorax"},{"issue":"8","key":"403_CR25","doi-asserted-by":"crossref","first-page":"e72365","DOI":"10.1371\/journal.pone.0072365","volume":"8","author":"SZ Hussein","year":"2013","unstructured":"Hussein SZ, MohdYusoff K, Makpol S, MohdYusof YA (2013) Gelam honey attenuates carrageenan-induced rat paw inflammation via NF-\u03baB pathway. PLoS One 8(8):e72365","journal-title":"PLoS One"},{"issue":"3A","key":"403_CR26","first-page":"933","volume":"14","author":"S Imai","year":"1994","unstructured":"Imai S, Sugiura M, Mizuno F, Ohigashi H, Koshimizu K, Chiba S (1994) African Burkitt\u2019s lymphoma: a plant, Euphorbia tirucalli, reduces Epstein-Barr virus-specific cellular immunity. Anticancer Res 14(3A):933\u2013936","journal-title":"Anticancer Res"},{"key":"403_CR27","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1006\/abbi.1995.9934","volume":"324","author":"JL Johnson","year":"1995","unstructured":"Johnson JL, Wimsatt J, Buckel SD, Dyer RD, Maddipati KR (1995) Purification and characterization of prostaglandin H synthase-2 from sheep placental cotyledons. Arch Biochem Biophys 324:26\u201334","journal-title":"Arch Biochem Biophys"},{"issue":"4","key":"403_CR28","first-page":"99","volume":"4","author":"A Khaleghian","year":"2010","unstructured":"Khaleghian A, Riazi GH, Ahmadian S, Ghafari M et al (2010) Effect of ferric oxide nanoparticles on microtubules organization. Afr J Biochem Res 4(4):99\u2013104","journal-title":"Afr J Biochem Res"},{"issue":"1","key":"403_CR29","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1046\/j.1365-2249.2000.01095.x","volume":"119","author":"WU Kim","year":"2000","unstructured":"Kim WU, Min SY, Cho ML, Youn J, Min JK, Lee SH (2000) The role of IL-12 in inflammatory activity of patients with rheumatoid arthritis (RA). Clin Exp Immunol 119(1):175\u2013181","journal-title":"Clin Exp Immunol"},{"issue":"2","key":"403_CR30","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.1016\/j.foodchem.2013.04.044","volume":"141","author":"CM Ku","year":"2013","unstructured":"Ku CM, Lin JY (2013) Anti-inflammatory effects of 27 selected terpenoid compounds tested through modulating Th1\/Th2 cytokine secretion profiles using murine primary splenocytes. Food Chem 141(2):1104\u20131113","journal-title":"Food Chem"},{"issue":"36","key":"403_CR31","doi-asserted-by":"crossref","first-page":"25934","DOI":"10.1016\/S0021-9258(18)35698-9","volume":"267","author":"SH Lee","year":"1992","unstructured":"Lee SH, Soyoola E, Chanmugam P, Hart S, Sun W, Zhong H et al (1992) Selective expression of mitogen-inducible cyclooxygenase in macrophages stimulated with lipopolysaccharide. J Biol Chem 267(36):25934\u201325938","journal-title":"J Biol Chem"},{"issue":"12","key":"403_CR32","doi-asserted-by":"crossref","first-page":"4333","DOI":"10.1016\/j.fct.2012.05.029","volume":"50","author":"MW Lin","year":"2012","unstructured":"Lin MW, Lin AS, Wu DC et al (2012) Euphol from Euphorbia tirucalli selectively inhibits human gastric cancer cell growth through the induction of ERK1\/2-mediated apoptosis. Food Chem Toxicol 50(12):4333\u20134339","journal-title":"Food Chem Toxicol"},{"issue":"2","key":"403_CR33","doi-asserted-by":"crossref","first-page":"279","DOI":"10.3109\/08923973.2010.502173","volume":"33","author":"DS Llanes-Coronel","year":"2011","unstructured":"Llanes-Coronel DS, G\u00e1mez-D\u00edaz LY, Suarez-Quintero LP, P\u00e1ez LJ, Torres F, Echeverri F et al (2011) New promising Euphorbiaceae extracts with activity in human lymphocytes from primary cell cultures. Immunopharmacol Immunotoxicol 33(2):279\u2013290","journal-title":"Immunopharmacol Immunotoxicol"},{"key":"403_CR34","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1186\/1476-9255-7-60","volume":"7","author":"DL Lucetti","year":"2010","unstructured":"Lucetti DL, Lucetti EC, Bandeira MA, Veras HN, Silva AH et al (2010) Anti-inflammatory effects and possible mechanism of action of lupeol acetate isolated from Himatanthusdrasticus (Mart.) Plumel. J Inflamm 7:60","journal-title":"J Inflamm"},{"key":"403_CR35","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/S0091-6749(03)01877-3","volume":"112","author":"D MacGlashan Jr","year":"2003","unstructured":"MacGlashan D Jr (2003) Histamine: a mediator of inflammation. J Allergy Clin Immunol 112:53\u201359","journal-title":"J Allergy Clin Immunol"},{"issue":"1","key":"403_CR36","first-page":"30","volume":"1","author":"IA Mardini","year":"2001","unstructured":"Mardini IA, FitzGerald GA (2001) Selective inhibitors of cyclooxygenase-2: a growing class of anti-inflammatory drugs. MolInterv 1(1):30\u201338","journal-title":"MolInterv"},{"issue":"4","key":"403_CR37","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.1172\/JCI114850","volume":"86","author":"JL Masferrer","year":"1990","unstructured":"Masferrer JL, Zweifel BS, Seibert K, Needleman P (1990) Selective regulation of cellular cyclooxygenase by dexamethasone and endotoxin in mice. J Clin Invest 86(4):1375","journal-title":"J Clin Invest"},{"issue":"11","key":"403_CR38","doi-asserted-by":"crossref","first-page":"6615","DOI":"10.4049\/jimmunol.167.11.6615","volume":"167","author":"S Miike","year":"2001","unstructured":"Miike S, McWilliam AS, Kita H (2001) Trypsin induces activation and inflammatory mediator release from human eosinophils through protease-activated receptor-2. J Immunol 167(11):6615\u20136622","journal-title":"J Immunol"},{"key":"403_CR39","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.phrs.2003.12.016","volume":"50","author":"J Mino","year":"2004","unstructured":"Mino J, Moscatelli V, Hnatyszyn O, Gorzalczany S, Acevedo C, Ferraro G (2004) Antinociceptive and antiinflammatory activities of Artemisia copa extracts. J Pharmacol Res 50:59\u201363","journal-title":"J Pharmacol Res"},{"issue":"1","key":"403_CR40","first-page":"16","volume":"22","author":"Y Mizushima","year":"1966","unstructured":"Mizushima Y, Nakagawa T (1966) Physicochemical and biochemical properties of non-steroid antirheumatic drugs. Rheumatism 22(1):16\u201323","journal-title":"Rheumatism"},{"issue":"23","key":"403_CR41","first-page":"4905","volume":"6","author":"TJ Mwine","year":"2011","unstructured":"Mwine TJ, Van Damme P (2011) Euphorbia tirucalli L. (Euphorbiaceae): the miracle tree: current status of available knowledge. Sci Res Essays 6(23):4905\u20134914","journal-title":"Sci Res Essays"},{"key":"403_CR42","first-page":"149","volume":"6","author":"AK Nag Chaudhari","year":"1974","unstructured":"Nag Chaudhari AK, Lahiri SC (1974) Use of goat trachea isolated tracheal chain preparation. Indian J Pharmacol 6:149\u2013151","journal-title":"Indian J Pharmacol"},{"key":"403_CR43","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1038\/sj.bjp.0702866","volume":"128","author":"F Nantel","year":"1999","unstructured":"Nantel F, Denis D, Gordon R, Northey A, Cirino M et al (1999) Distribution and regulation of cyclooxygenase-2 in carrageenan-induced inflammation. Brit J Pharmacol 128:853\u2013859","journal-title":"Brit J Pharmacol"},{"issue":"2","key":"403_CR44","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1007\/s11882-017-0678-1","volume":"17","author":"MT Opina","year":"2017","unstructured":"Opina MT, Moore WC (2017) Phenotype-driven therapeutics in severe asthma. Curr Allergy Asthma Rep 17(2):10","journal-title":"Curr Allergy Asthma Rep"},{"key":"403_CR45","doi-asserted-by":"crossref","first-page":"65","DOI":"10.3109\/13880209509088150","volume":"33","author":"OO Oyedapo","year":"1995","unstructured":"Oyedapo OO, Famurewa AJ (1995) Anti-protease and membrane stabilizing activities of extracts of Fagrazanthoxiloides, Olaxsubscorpioides and Tetrapleura tetraptera. Int J Pharmacogn 33:65\u201369","journal-title":"Int J Pharmacogn"},{"key":"403_CR46","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1007\/978-3-642-64958-5","volume-title":"Modern methods in plant analysis","author":"T Paech","year":"1955","unstructured":"Paech T, Tracy MV (1955) Modern methods in plant analysis. Springer, Berlin, p 387"},{"key":"403_CR47","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.intimp.2016.10.024","volume":"41","author":"P Palit","year":"2016","unstructured":"Palit P, Mandal SC, Bhunia B (2016) Total steroid and terpenoid enriched fraction from Euphorbia neriifolia Linn offers protection against nociceptive-pain, inflammation, and in vitro arthritis model: an insight of mechanistic study. Int Immunopharmacol 41:106\u2013115","journal-title":"Int Immunopharmacol"},{"issue":"1","key":"403_CR48","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/j.ejphar.2012.10.019","volume":"698","author":"GF Passos","year":"2013","unstructured":"Passos GF, Medeiros R, Marcon R, Nascimento AF, Calixto JB, Pianowski LF (2013) The role of PKC\/ERK1\/2 signaling in the anti-inflammatory effect of tetracyclic triterpene euphol on TPA-induced skin inflammation in mice. Eur J Pharmacol 698(1):413\u2013420","journal-title":"Eur J Pharmacol"},{"issue":"2","key":"403_CR49","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1038\/sj.bjp.0705650","volume":"142","author":"I Posadas","year":"2004","unstructured":"Posadas I, Bucci M, Roviezzo F, Rossi A, Parente L, Sautebin L et al (2004) Carrageenan-induced mouse paw oedema is biphasic, age-weight dependent and displays differential nitric oxide cyclooxygenase-2 expression. Br J Pharmacol 142(2):331\u2013338","journal-title":"Br J Pharmacol"},{"issue":"5","key":"403_CR50","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1111\/j.1365-2036.2008.03905.x","volume":"29","author":"A Rostom","year":"2009","unstructured":"Rostom A, Moayyedi P, Hunt R (2009) Canadian consensus guidelines on long-term nonsteroidal anti-inflammatory drug therapy and the need for gastroprotection: benefits versus risks. Aliment Pharmacol Ther 29(5):481\u2013496","journal-title":"Aliment Pharmacol Ther"},{"key":"403_CR51","first-page":"525","volume":"60","author":"J Sadique","year":"1989","unstructured":"Sadique J, Al-Rqobahs WA, Bughaith MF, El-Gindi AR (1989) The bioactivity of certain medicinal plants on the stabilization of RBC membrane system. Fitoterpia 60:525\u2013532","journal-title":"Fitoterpia"},{"issue":"4","key":"403_CR52","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1590\/S0102-67202013000400002","volume":"26","author":"OJ Santos","year":"2013","unstructured":"Santos OJ, Carvalho-J\u00fanior FF, Sauaia-Filho EN, Santos RH, Santos RA, Barbalho WG (2013) Gastric healing process with raw extract of Euphorbia tirucalli L.: study in rats. ABCD. Arquivos Brasileiros de Cirurgia Digestiva (S\u00e3o Paulo) 26(4):256\u2013259","journal-title":"ABCD. Arquivos Brasileiros de Cirurgia Digestiva (S\u00e3o Paulo)"},{"issue":"2","key":"403_CR53","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1007\/BF02976483","volume":"24","author":"L Saso","year":"2001","unstructured":"Saso L, Valentini G, Casini ML, Grippa E, Gatto MT, Leone MG (2001) Inhibition of heat-induced denaturation of albumin by nonsteroidal antiinflammatory drugs (NSAIDs): pharmacological implications. Arch Pharm Res 24(2):150\u2013158","journal-title":"Arch Pharm Res"},{"issue":"10","key":"403_CR54","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1590\/S0102-86502013001000005","volume":"28","author":"EN Sauaia Filho","year":"2013","unstructured":"Sauaia Filho EN, Santos OJ, Barros Filho AK, Rocha AD et al (2013) Evaluation of the use of raw extract of Euphorbia tirucalli L. in the healing process of skin wounds in mice. Acta Cirurgica Brasileira 28(10):716\u2013720","journal-title":"Acta Cirurgica Brasileira"},{"issue":"1","key":"403_CR55","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1163\/156856004773121400","volume":"12","author":"JN Sharma","year":"2004","unstructured":"Sharma JN, Samud AM, Asmawi MZ (2004) Comparisons between plethysmometer and micrometer methods to measure acute paw oedema for screening anti-inflammatory activity in mice. Inflammopharmacology 12(1):89\u201394","journal-title":"Inflammopharmacology"},{"issue":"6","key":"403_CR56","first-page":"1019","volume":"8","author":"M Sugiura","year":"1994","unstructured":"Sugiura M, Imai S, Sakurada K, Miyazaki T, Osato T (1994) Cryptic dysfunction of cellular immunity in asymptomatic human immunodeficiency virus (HIV) carriers and its actualization by an environmental immunosuppressive factor. Vivo 8(6):1019\u20131022","journal-title":"Vivo"},{"issue":"1","key":"403_CR57","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1146\/annurev.pharmtox.42.092401.143905","volume":"42","author":"CI Svensson","year":"2002","unstructured":"Svensson CI, Yaksh TL (2002) The spinal phospholipase-cyclooxygenase-prostanoid cascade in nociceptive processing. Annu Rev Pharmacol Toxicol 42(1):553\u2013583","journal-title":"Annu Rev Pharmacol Toxicol"},{"issue":"4","key":"403_CR58","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1081\/IPH-200042279","volume":"26","author":"A Tadesse","year":"2004","unstructured":"Tadesse A, Sandoval F, Shannon EJ (2004) Stabilization of red blood cell membranes by thalidomide in vitro. Immunopharmacol Immunotoxicol 26(4):501\u2013509","journal-title":"Immunopharmacol Immunotoxicol"},{"issue":"1","key":"403_CR59","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1111\/j.1600-065X.2008.00628.x","volume":"223","author":"LA Tesmer","year":"2008","unstructured":"Tesmer LA, Lundy SK, Sarkar S, Fox DA (2008) Th17 cells in human disease. Immunol Rev 223(1):87\u2013113","journal-title":"Immunol Rev"},{"key":"403_CR60","first-page":"227","volume-title":"The dictionary of Indian raw materials and industrial products","author":"Wealth of India","year":"1952","unstructured":"Wealth of India (1952) The dictionary of Indian raw materials and industrial products, vol 3. Council of Scientific and Industrial Research, New Delhi, p 227"},{"key":"403_CR61","doi-asserted-by":"crossref","first-page":"4440","DOI":"10.1016\/j.bmcl.2006.06.036","volume":"16","author":"WJ Tsai","year":"2006","unstructured":"Tsai WJ, Shiao YJ, Lin SJ, Chiou WF, Lin LC, Yang TH (2006) Selective COX-2 inhibitors Part 1: synthesis and biological evaluation of Phenylazobenzene Sulfonamides. Bioorg Med Chem Lett 16:4440\u20134443","journal-title":"Bioorg Med Chem Lett"},{"key":"403_CR62","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/B978-1-4832-3266-9.50012-8","volume-title":"Screening methods in pharmacology","author":"RA Turner","year":"1965","unstructured":"Turner RA (1965) Analgesics. In: Turner RA (ed) Screening methods in pharmacology. Academic Press, London, p 100"},{"issue":"2","key":"403_CR63","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/j.intimp.2005.07.013","volume":"6","author":"MC Valadares","year":"2006","unstructured":"Valadares MC, Carrucha SG, Accorsi W, Queiroz ML (2006) Euphorbia tirucalli L. modulates myelopoiesis and enhances the resistance of tumour-bearing mice. Int Immunopharmacol 6(2):294\u2013299","journal-title":"Int Immunopharmacol"},{"issue":"7","key":"403_CR64","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1038\/sj.bjp.0705999","volume":"143","author":"ML Vale","year":"2004","unstructured":"Vale ML, Benevides VM, Sachs D, Brito GA, da Rocha FA, Poole S et al (2004) Antihyperalgesic effect of pentoxifylline on experimental inflammatory pain. Br J Pharmacol 143(7):833\u2013844","journal-title":"Br J Pharmacol"},{"issue":"5","key":"403_CR65","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1007\/s00011-015-0814-0","volume":"64","author":"E Vazquez","year":"2015","unstructured":"Vazquez E (2015) Systemic changes following carrageenan-induced paw inflammation in rats. Inflamm Res 64(5):333\u2013342","journal-title":"Inflamm Res"},{"issue":"41","key":"403_CR66","doi-asserted-by":"crossref","first-page":"25693","DOI":"10.1074\/jbc.272.41.25693","volume":"272","author":"JA Williams","year":"1997","unstructured":"Williams JA, Shacter E (1997) Regulation of macrophage cytokine production by prostaglandin E2 distinct roles of cyclooxygenase-1 and -2. J Biol Chem 272(41):25693\u201325699","journal-title":"J Biol Chem"},{"key":"403_CR67","doi-asserted-by":"crossref","first-page":"544","DOI":"10.3181\/00379727-111-27849","volume":"111","author":"CA Winter","year":"1962","unstructured":"Winter CA, Risley EA, Nuss GW (1962) Carrageenan-induced edema in hind paw of the rats as an assay anti-inflammatory drugs. Proc Soc Exp Biol Med 111:544\u2013547","journal-title":"Proc Soc Exp Biol Med"},{"key":"403_CR68","doi-asserted-by":"crossref","first-page":"1959","DOI":"10.1016\/S0140-6736(99)01307-0","volume":"353","author":"CJ Woolf","year":"1999","unstructured":"Woolf CJ, Mannion RJ (1999) Neuropathic pain: aetiology, symptoms, mechanisms, and management. Lancet 353:1959\u20131964","journal-title":"Lancet"},{"issue":"20","key":"403_CR69","doi-asserted-by":"crossref","first-page":"E2081","DOI":"10.1073\/pnas.1403379111","volume":"111","author":"AR Wyatt","year":"2014","unstructured":"Wyatt AR, Kumita JR, Mifsud RW, Gooden CA, Wilson MR, Dobson CM (2014) Hypochlorite-induced structural modifications enhance the chaperone activity of human \u03b12-macroglobulin. Proc Natl Acad Sci USA. 111(20):E2081\u2013E2090","journal-title":"Proc Natl Acad Sci USA."},{"issue":"4","key":"403_CR70","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/j.phymed.2010.08.013","volume":"18","author":"W Xin","year":"2011","unstructured":"Xin W, Zhang L, Sun F, Jiang N, Fan H, Wang T (2011) Escin exerts synergistic anti-inflammatory effects with low doses of glucocorticoids in vivo and in vitro. Phytomedicine 18(4):272\u2013277","journal-title":"Phytomedicine"}],"container-title":["Inflammopharmacology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10787-017-0403-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10787-017-0403-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10787-017-0403-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,27]],"date-time":"2023-08-27T12:57:17Z","timestamp":1693141037000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10787-017-0403-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,10,23]]},"references-count":70,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,2]]}},"alternative-id":["403"],"URL":"https:\/\/doi.org\/10.1007\/s10787-017-0403-7","relation":{},"ISSN":["0925-4692","1568-5608"],"issn-type":[{"value":"0925-4692","type":"print"},{"value":"1568-5608","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,10,23]]}}}