{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T14:59:47Z","timestamp":1787497187874,"version":"build-2736575974"},"reference-count":48,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2017,11,29]],"date-time":"2017-11-29T00:00:00Z","timestamp":1511913600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100004612","name":"Funda\u00e7\u00e3o Arauc\u00e1ria","doi-asserted-by":"publisher","award":["672\/2014"],"award-info":[{"award-number":["672\/2014"]}],"id":[{"id":"10.13039\/501100004612","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Inflammopharmacol"],"published-print":{"date-parts":[[2018,6]]},"DOI":"10.1007\/s10787-017-0425-1","type":"journal-article","created":{"date-parts":[[2017,11,29]],"date-time":"2017-11-29T00:19:49Z","timestamp":1511914789000},"page":"793-804","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Effect of simvastatin on sensorial, motor, and morphological parameters in sciatic nerve crush induced-neuropathic pain in rats"],"prefix":"10.1007","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6594-3542","authenticated-orcid":false,"given":"Claudia Rita","family":"Corso","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel Fernandes","family":"Martins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie Carvalho","family":"Borges","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olair Carlos","family":"Beltrame","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Ederaldo Queiroz","family":"Telles","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nilza Cristina","family":"Buttow","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Fernanda de Paula","family":"Werner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,11,29]]},"reference":[{"key":"425_CR1","doi-asserted-by":"publisher","first-page":"276","DOI":"10.1161\/01.CIR.103.2.276","volume":"103","author":"M Aikawa","year":"2001","unstructured":"Aikawa M, Rabkin E, Sugiyama S et al (2001) An HMG-CoA reductase inhibitor, cerivastatin, suppresses growth of macrophages expressing matrix metalloproteinases and tissue factor in vivo and in vitro. Circulation 103:276\u2013283. https:\/\/doi.org\/10.1161\/01.CIR.103.2.276","journal-title":"Circulation"},{"key":"425_CR2","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/0076-6879(88)62087-8","volume":"162","author":"PJ Bailey","year":"1988","unstructured":"Bailey PJ (1988) Sponge implants as models. Methods Enzym 162:327\u2013334","journal-title":"Methods Enzym"},{"key":"425_CR3","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-540-79090-7_1","author":"R Baron","year":"2009","unstructured":"Baron R (2009) Neuropathic pain: a clinical perspective. Handb Exp Pharmacol. https:\/\/doi.org\/10.1007\/978-3-540-79090-7_1","journal-title":"Handb Exp Pharmacol"},{"key":"425_CR4","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1016\/j.fct.2015.02.016","volume":"80","author":"S Bhalla","year":"2015","unstructured":"Bhalla S, Singh N, Jaggi AS (2015) Dose-related neuropathic and anti-neuropathic effects of simvastatin in vincristine-induced neuropathic pain in rats. Food Chem Toxicol 80:32\u201340. https:\/\/doi.org\/10.1016\/j.fct.2015.02.016","journal-title":"Food Chem Toxicol"},{"key":"425_CR5","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/0003-2697(76)90527-3","volume":"72","author":"MM Bradford","year":"1976","unstructured":"Bradford MM (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72:248\u2013254","journal-title":"Anal Biochem"},{"key":"425_CR6","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1111\/1523-1747.ep12506462","volume":"78","author":"PP Bradley","year":"1982","unstructured":"Bradley PP, Priebat DA, Christensen RD, Rothstein G (1982) Measurement of cutaneous inflammation: estimation of neutrophil content with an enzyme marker. J Invest Dermatol 78:206\u2013209","journal-title":"J Invest Dermatol"},{"key":"425_CR7","doi-asserted-by":"publisher","first-page":"558","DOI":"10.1097\/MOL.0b013e328319baba","volume":"19","author":"WV Brown","year":"2008","unstructured":"Brown WV (2008) Safety of statins. Curr Opin Lipidol 19:558\u2013562. https:\/\/doi.org\/10.1097\/MOL.0b013e328319baba","journal-title":"Curr Opin Lipidol"},{"key":"425_CR8","doi-asserted-by":"publisher","first-page":"765","DOI":"10.1161\/01.ATV.0000015078.09208.92","volume":"22","author":"AJ Chase","year":"2002","unstructured":"Chase AJ, Bond M, Crook MF, Newby AC (2002) Role of nuclear factor-kB activation in metalloproteinase-1, -3, and -9 secretion by human macrophages in vitro and rabbit foam cells produced in vivo. Arterioscler Thromb Vasc Biol 22:765\u2013771. https:\/\/doi.org\/10.1161\/01.ATV.0000015078.09208.92","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"425_CR9","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/0165-0270(94)00156-B","volume":"58","author":"L Medinaceli de","year":"1995","unstructured":"de Medinaceli L (1995) Interpreting nerve morphometry data after experimental traumatic lesions. J Neurosci Methods 58:29\u201337","journal-title":"J Neurosci Methods"},{"key":"425_CR10","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1007\/BF01967298","volume":"26","author":"LM Young De","year":"1989","unstructured":"De Young LM, Kheifets JB, Ballaron SJ, Young JM (1989) Edema and cell infiltration in the phorbol ester-treated mouse ear are temporally separate and can be differentially modulated by pharmacologic agents. Agents Actions 26:335\u2013341","journal-title":"Agents Actions"},{"key":"425_CR11","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1590\/1414-431X20122462","volume":"46","author":"QM Dias","year":"2013","unstructured":"Dias QM, Rossaneis AC, Fais RS, Prado WA (2013) An improved experimental model for peripheral neuropathy in rats. Brazilian J Med Biol Res 46:253\u2013256. https:\/\/doi.org\/10.1590\/1414-431X20122462","journal-title":"Brazilian J Med Biol Res"},{"key":"425_CR13","doi-asserted-by":"publisher","first-page":"393","DOI":"10.3949\/ccjm.78a.10073","volume":"78","author":"G Fernandez","year":"2011","unstructured":"Fernandez G, Spatz ES, Jablecki C, Phillips PS (2011) Statin myopathy: a common dilemma not reflected in clinical trials. Cleve Clin J Med 78:393\u2013403. https:\/\/doi.org\/10.3949\/ccjm.78a.10073","journal-title":"Cleve Clin J Med"},{"key":"425_CR14","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1212\/WNL.58.9.1333","volume":"58","author":"D Gaist","year":"2002","unstructured":"Gaist D, Jeppesen U, Andersen M et al (2002) Statins and risk of polyneuropathy: a case-control study. Neurology 58:1333\u20131337","journal-title":"Neurology"},{"key":"425_CR15","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1016\/j.pbb.2011.08.007","volume":"100","author":"GG Garcia","year":"2011","unstructured":"Garcia GG, Miranda HF, Noriega V et al (2011) Antinociception induced by atorvastatin in different pain models. Pharmacol Biochem Behav 100:125\u2013129. https:\/\/doi.org\/10.1016\/j.pbb.2011.08.007","journal-title":"Pharmacol Biochem Behav"},{"key":"425_CR16","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1007\/s10787-010-0044-6","volume":"18","author":"MM Ghaisas","year":"2010","unstructured":"Ghaisas MM, Dandawate PR, Zawar SA et al (2010) Antioxidant, antinociceptive and anti-inflammatory activities of atorvastatin and rosuvastatin in various experimental models. Inflammopharmacology 18:169\u2013177. https:\/\/doi.org\/10.1007\/s10787-010-0044-6","journal-title":"Inflammopharmacology"},{"key":"425_CR17","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1161\/01.HYP.36.3.325","volume":"36","author":"U Ikeda","year":"2000","unstructured":"Ikeda U, Shimpo M, Ohki R et al (2000) Fluvastatin inhibits matrix metalloproteinase-1 expression in human vascular endothelial cells. Hypertension 36:325\u2013329. https:\/\/doi.org\/10.1161\/01.HYP.36.3.325","journal-title":"Hypertension"},{"key":"425_CR18","doi-asserted-by":"publisher","first-page":"475","DOI":"10.4103\/0253-7613.99311","volume":"44","author":"SR Jaiswal","year":"2012","unstructured":"Jaiswal SR, Sontakke SD (2012) Experimental evaluation of analgesic and anti-inflammatory activity of simvastatin and atorvastatin. Indian J Pharmacol 44:475\u2013479. https:\/\/doi.org\/10.4103\/0253-7613.99311","journal-title":"Indian J Pharmacol"},{"key":"425_CR19","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1007\/s12272-013-0057-y","volume":"36","author":"A Kukkar","year":"2013","unstructured":"Kukkar A, Bali A, Singh N, Jaggi AS (2013) Implications and mechanism of action of gabapentin in neuropathic pain. Arch Pharm Res 36:237\u2013251. https:\/\/doi.org\/10.1007\/s12272-013-0057-y","journal-title":"Arch Pharm Res"},{"key":"425_CR20","doi-asserted-by":"publisher","DOI":"10.1016\/j.jfma.2013.05.013","author":"A Kukkar","year":"2013","unstructured":"Kukkar A, Singh N, Jaggi AS (2014) Attenuation of neuropathic pain by sodium butyrate in an experimental model of chronic constriction injury in rats. J Formos Med Assoc. https:\/\/doi.org\/10.1016\/j.jfma.2013.05.013","journal-title":"J Formos Med Assoc"},{"key":"425_CR21","doi-asserted-by":"crossref","first-page":"81","DOI":"10.3346\/jkms.2002.17.1.81","volume":"17","author":"I Lee","year":"2002","unstructured":"Lee I, Jeong Y (2002) Effects of different concentrations of formalin on paw edema and pain behaviors in rats. J Korean Med Sci 17:81\u201385","journal-title":"J Korean Med Sci"},{"key":"425_CR22","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1016\/j.pain.2008.04.025","volume":"137","author":"JD Loeser","year":"2008","unstructured":"Loeser JD, Treede R-D (2008) The Kyoto protocol of IASP basic pain terminology. Pain 137:473\u2013477. https:\/\/doi.org\/10.1016\/j.pain.2008.04.025","journal-title":"Pain"},{"key":"425_CR23","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1227\/01.NEU.0000343540.24780.D6.LONG-TERM","volume":"65","author":"A Mahmood","year":"2009","unstructured":"Mahmood A, Goussev A, Kazmi H et al (2009) Long-term benefits after treatment of traumatic brains injury with simvastatin in rats. Neurosurgery 65:187\u2013192. https:\/\/doi.org\/10.1227\/01.NEU.0000343540.24780.D6.LONG-TERM","journal-title":"Neurosurgery"},{"key":"425_CR24","doi-asserted-by":"publisher","first-page":"1776","DOI":"10.1002\/jnr.24008","volume":"95","author":"MT Mansouri","year":"2017","unstructured":"Mansouri MT, Naghizadeh B, Ghorbanzadeh B, Alboghobeish S (2017) Systemic and local anti-nociceptive effects of simvastatin in the rat formalin assay: role of peroxisome proliferator-activated receptor \u03b3 and nitric oxide. J Neurosci Res 95:1776\u20131785. https:\/\/doi.org\/10.1002\/jnr.24008","journal-title":"J Neurosci Res"},{"key":"425_CR25","doi-asserted-by":"publisher","first-page":"2653","DOI":"10.1016\/j.pain.2011.08.014","volume":"152","author":"DF Martins","year":"2011","unstructured":"Martins DF, Mazzardo-Martins L, Gadotti VM et al (2011) Ankle joint mobilization reduces axonotmesis-induced neuropathic pain and glial activation in the spinal cord and enhances nerve regeneration in rats. Pain 152:2653\u20132661. https:\/\/doi.org\/10.1016\/j.pain.2011.08.014","journal-title":"Pain"},{"key":"425_CR26","doi-asserted-by":"publisher","first-page":"1243","DOI":"10.1056\/NEJMcp022282","volume":"348","author":"JR Mendell","year":"2003","unstructured":"Mendell JR, Sahenk Z (2003) Clinical practice: painful sensory neuropathy. N Engl J Med 348:1243\u20131255. https:\/\/doi.org\/10.1056\/NEJMcp022282","journal-title":"N Engl J Med"},{"key":"425_CR27","doi-asserted-by":"publisher","first-page":"438","DOI":"10.1111\/j.1742-7843.2011.00746.x","volume":"109","author":"HF Miranda","year":"2011","unstructured":"Miranda HF, Noriega V, Olavarria L et al (2011) Antinociception and anti-inflammation induced by simvastatin in algesiometric assays in mice. Basic Clin Pharmacol Toxicol 109:438\u2013442. https:\/\/doi.org\/10.1111\/j.1742-7843.2011.00746.x","journal-title":"Basic Clin Pharmacol Toxicol"},{"key":"425_CR28","doi-asserted-by":"publisher","first-page":"1880","DOI":"10.2353\/ajpath.2009.080947","volume":"174","author":"VE Miron","year":"2009","unstructured":"Miron VE, Zehntner SP, Kuhlmann T et al (2009) Statin therapy inhibits remyelination in the central nervous system. Am J Pathol 174:1880\u20131890. https:\/\/doi.org\/10.2353\/ajpath.2009.080947","journal-title":"Am J Pathol"},{"key":"425_CR29","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1016\/j.pain.2007.04.031","volume":"134","author":"M Ohsawa","year":"2008","unstructured":"Ohsawa M, Mutoh J, Hisa H (2008) Mevalonate sensitizes the nociceptive transmission in the mouse spinal cord. Pain 134:285\u2013292. https:\/\/doi.org\/10.1016\/j.pain.2007.04.031","journal-title":"Pain"},{"key":"425_CR30","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1016\/j.pain.2010.10.005","volume":"152","author":"M Ohsawa","year":"2011","unstructured":"Ohsawa M, Aasato M, Hayashi S-S, Kamei J (2011) RhoA\/Rho kinase pathway contributes to the pathogenesis of thermal hyperalgesia in diabetic mice. Pain 152:114\u2013122. https:\/\/doi.org\/10.1016\/j.pain.2010.10.005","journal-title":"Pain"},{"key":"425_CR31","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1254\/jphs.12007SC","volume":"119","author":"M Ohsawa","year":"2012","unstructured":"Ohsawa M, Mutoh J, Yamamoto S et al (2012) Effect of spinally administered simvastatin on the formalin-induced nociceptive response in mice. J Pharmacol Sci 119:102\u2013106. https:\/\/doi.org\/10.1254\/jphs.12007SC","journal-title":"J Pharmacol Sci"},{"key":"425_CR32","doi-asserted-by":"publisher","first-page":"292","DOI":"10.1254\/jphs.14058FP","volume":"125","author":"M Ohsawa","year":"2014","unstructured":"Ohsawa M, Otake S, Murakami T et al (2014) Gabapentin prevents oxaliplatin-induced mechanical hyperalgesia in mice. J Pharmacol Sci 125:292\u2013299. https:\/\/doi.org\/10.1254\/jphs.14058FP","journal-title":"J Pharmacol Sci"},{"key":"425_CR33","doi-asserted-by":"publisher","first-page":"376","DOI":"10.1227\/01.NEU.0000371729.47895.A0","volume":"67","author":"HC Pan","year":"2010","unstructured":"Pan HC, Yang DY, Ou YC et al (2010) Neuroprotective effect of atorvastatin in an experimental model of nerve crush injury. Neurosurgery 67:376\u2013388. https:\/\/doi.org\/10.1227\/01.NEU.0000371729.47895.A0","journal-title":"Neurosurgery"},{"key":"425_CR34","doi-asserted-by":"publisher","first-page":"182","DOI":"10.1111\/j.1471-4159.2006.04354.x","volume":"101","author":"R Pannu","year":"2007","unstructured":"Pannu R, Christie DK, Barbosa E et al (2007) Post-trauma Lipitor treatment prevents endothelial dysfunction, facilitates neuroprotection, and promotes locomotor recovery following spinal cord injury. J Neurochem 101:182\u2013200. https:\/\/doi.org\/10.1111\/j.1471-4159.2006.04354.x","journal-title":"J Neurochem"},{"key":"425_CR35","doi-asserted-by":"publisher","first-page":"1468","DOI":"10.1007\/s10753-013-9688-x","volume":"36","author":"NN Pathak","year":"2013","unstructured":"Pathak NN, Balaganur V, Lingaraju MC et al (2013) Antihyperalgesic and anti-inflammatory effects of atorvastatin in chronic constriction injury-induced neuropathic pain in rats. Inflammation 36:1468\u20131478. https:\/\/doi.org\/10.1007\/s10753-013-9688-x","journal-title":"Inflammation"},{"key":"425_CR36","doi-asserted-by":"publisher","first-page":"625","DOI":"10.1136\/jnnp.58.5.625","volume":"58","author":"T Phan","year":"1995","unstructured":"Phan T, McLeod JG, Pollard JD et al (1995) Peripheral neuropathy associated with simvastatin. J Neurol Neurosurg Psychiatry 58:625\u2013628. https:\/\/doi.org\/10.1136\/jnnp.58.5.625","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"425_CR37","doi-asserted-by":"publisher","first-page":"673","DOI":"10.1016\/j.neuroscience.2008.06.034","volume":"155","author":"I Roglio","year":"2008","unstructured":"Roglio I, Bianchi R, Gotti S et al (2008) Neuroprotective effects of dihydroprogesterone and progesterone in an experimental model of nerve crush injury. Neuroscience 155:673\u2013685. https:\/\/doi.org\/10.1016\/j.neuroscience.2008.06.034","journal-title":"Neuroscience"},{"key":"425_CR38","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1002\/ar.1092150111","volume":"215","author":"H Schmalbruch","year":"1986","unstructured":"Schmalbruch H (1986) Fiber composition of the rat sciatic nerve. Anat Rec 215:71\u201381. https:\/\/doi.org\/10.1002\/ar.1092150111","journal-title":"Anat Rec"},{"key":"425_CR39","doi-asserted-by":"publisher","first-page":"1033","DOI":"10.1016\/j.pain.2011.01.006","volume":"152","author":"XQ Shi","year":"2011","unstructured":"Shi XQ, Lim TKY, Lee S et al (2011) Statins alleviate experimental nerve injury-induced neuropathic pain. Pain 152:1033\u20131043. https:\/\/doi.org\/10.1016\/j.pain.2011.01.006","journal-title":"Pain"},{"key":"425_CR40","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/S0006-8993(99)02321-5","volume":"855","author":"VI Shubayev","year":"2000","unstructured":"Shubayev VI, Myers RR (2000) Upregulation and interaction of TNFalpha and gelatinases A and B in painful peripheral nerve injury. Brain Res 855:83\u201389","journal-title":"Brain Res"},{"key":"425_CR41","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2014.03.002","author":"CR Sirtori","year":"2014","unstructured":"Sirtori CR (2014) The pharmacology of statins. Pharmacol Res. https:\/\/doi.org\/10.1016\/j.phrs.2014.03.002","journal-title":"Pharmacol Res"},{"key":"425_CR42","doi-asserted-by":"crossref","first-page":"1652","DOI":"10.1089\/neu.2004.21.1652","volume":"21","author":"ASP Varej\u00e3o","year":"2004","unstructured":"Varej\u00e3o ASP, Cabrita AM, Meek MF et al (2004) Functional and morphological assessment of a standardized rat sciatic nerve crush injury with a non-serrated clamp. J Neurotrauma 21:1652\u20131670","journal-title":"J Neurotrauma"},{"key":"425_CR43","doi-asserted-by":"publisher","first-page":"372","DOI":"10.1016\/j.mayocp.2016.01.017","volume":"91","author":"JC Watson","year":"2016","unstructured":"Watson JC, Sandroni P (2016) Central neuropathic pain syndromes. Mayo Clin Proc 91:372\u2013385. https:\/\/doi.org\/10.1016\/j.mayocp.2016.01.017","journal-title":"Mayo Clin Proc"},{"key":"425_CR44","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1016\/j.neuropharm.2007.04.013","volume":"53","author":"MFP Werner","year":"2007","unstructured":"Werner MFP, Kassuya CAL, Ferreira J et al (2007) Peripheral kinin B(1) and B(2) receptor-operated mechanisms are implicated in neuropathic nociception induced by spinal nerve ligation in rats. Neuropharmacology 53:48\u201357. https:\/\/doi.org\/10.1016\/j.neuropharm.2007.04.013","journal-title":"Neuropharmacology"},{"key":"425_CR45","doi-asserted-by":"publisher","first-page":"57","DOI":"10.3109\/08990220.2013.840281","volume":"31","author":"B West","year":"2014","unstructured":"West B, Williams CM, Jilbert E et al (2014) Statin use and peripheral sensory perception: a pilot study. Somatosens Mot Res 31:57\u201361. https:\/\/doi.org\/10.3109\/08990220.2013.840281","journal-title":"Somatosens Mot Res"},{"key":"425_CR46","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1189\/jlb.69.6.959","volume":"69","author":"B Wong","year":"2001","unstructured":"Wong B, Lumma WC, Smith AM et al (2001) Statins suppress THP-1 cell migration and secretion of matrix metalloproteinase 9 by inhibiting geranylgeranylation. J Leukoc Biol 69:959\u2013962","journal-title":"J Leukoc Biol"},{"key":"425_CR47","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1089\/neu.2007.0369","volume":"25","author":"H Wu","year":"2008","unstructured":"Wu H, Lu D, Jiang H et al (2008) Simvastatin-mediated upregulation of VEGF and BDNF, activation of the PI3\u00a0K\/Akt pathway, and increase of neurogenesis are associated with therapeutic improvement after traumatic brain injury. J Neurotrauma 25:130\u2013139. https:\/\/doi.org\/10.1089\/neu.2007.0369","journal-title":"J Neurotrauma"},{"key":"425_CR48","doi-asserted-by":"publisher","first-page":"284","DOI":"10.1016\/j.injury.2011.05.036","volume":"43","author":"AM Xavier","year":"2012","unstructured":"Xavier AM, Serafim KGG, Higashi DT et al (2012) Simvastatin improves morphological and functional recovery of sciatic nerve injury in Wistar rats. Injury 43:284\u2013289. https:\/\/doi.org\/10.1016\/j.injury.2011.05.036","journal-title":"Injury"},{"key":"425_CR49","doi-asserted-by":"publisher","first-page":"1865","DOI":"10.1007\/s10753-014-9918-x","volume":"37","author":"Y Zhao","year":"2014","unstructured":"Zhao Y, Feng Q, Huang Z et al (2014) Simvastatin inhibits inflammation in ischemia-reperfusion injury. Inflammation 37:1865\u20131875. https:\/\/doi.org\/10.1007\/s10753-014-9918-x","journal-title":"Inflammation"}],"container-title":["Inflammopharmacology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10787-017-0425-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10787-017-0425-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10787-017-0425-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,29]],"date-time":"2023-08-29T09:01:49Z","timestamp":1693299709000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10787-017-0425-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,11,29]]},"references-count":48,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2018,6]]}},"alternative-id":["425"],"URL":"https:\/\/doi.org\/10.1007\/s10787-017-0425-1","relation":{},"ISSN":["0925-4692","1568-5608"],"issn-type":[{"value":"0925-4692","type":"print"},{"value":"1568-5608","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,11,29]]}}}