{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T19:49:27Z","timestamp":1785354567705,"version":"3.55.0"},"reference-count":75,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2018,2,5]],"date-time":"2018-02-05T00:00:00Z","timestamp":1517788800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100002322","name":"CAPES","doi-asserted-by":"crossref","award":["Proc. 88881.120909\/2016-01"],"award-info":[{"award-number":["Proc. 88881.120909\/2016-01"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003593","name":"CNPq","doi-asserted-by":"crossref","award":["407768\/2013-0"],"award-info":[{"award-number":["407768\/2013-0"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"crossref"}]},{"name":"DGAPA-UNAM","award":["PREI-2017"],"award-info":[{"award-number":["PREI-2017"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Inflammopharmacol"],"published-print":{"date-parts":[[2018,8]]},"DOI":"10.1007\/s10787-017-0438-9","type":"journal-article","created":{"date-parts":[[2018,2,5]],"date-time":"2018-02-05T05:56:37Z","timestamp":1517810197000},"page":"1057-1080","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":88,"title":["Anti-inflammatory activity of nanoemulsions of essential oil from Rosmarinus officinalis L.: in vitro and in zebrafish studies"],"prefix":"10.1007","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6145-7130","authenticated-orcid":false,"given":"Raphaelle Sousa","family":"Borges","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9168-8995","authenticated-orcid":false,"given":"Hady","family":"Keita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8442-5908","authenticated-orcid":false,"given":"Brenda Lorena S\u00e1nchez","family":"Ortiz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8519-7310","authenticated-orcid":false,"given":"Tafnis Ingret","family":"dos Santos Sampaio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4517-0105","authenticated-orcid":false,"given":"Irlon Maciel","family":"Ferreira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9367-2812","authenticated-orcid":false,"given":"Emerson Silva","family":"Lima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9311-3159","authenticated-orcid":false,"given":"M\u00e1rcia","family":"de Jesus Amazonas da Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6538-7360","authenticated-orcid":false,"given":"Caio Pinho","family":"Fernandes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9337-4519","authenticated-orcid":false,"given":"Anna Eliza Maciel","family":"de Faria Mota Oliveira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4113-2686","authenticated-orcid":false,"given":"Edemilson Cardoso","family":"da Concei\u00e7\u00e3o","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2170-1773","authenticated-orcid":false,"given":"Alex Bruno Lobato","family":"Rodrigues","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arlindo C\u00e9sar Matias Pereira","family":"Filho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2858-8710","authenticated-orcid":false,"given":"Andr\u00e9s Navarrete","family":"Castro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3662-9794","authenticated-orcid":false,"given":"Jos\u00e9 Carlos Tavares","family":"Carvalho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,2,5]]},"reference":[{"key":"438_CR1","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1016\/j.ejphar.2011.12.024","volume":"678","author":"SI Abdelwahab","year":"2012","unstructured":"Abdelwahab SI, Koko WS, Taha MME, Mohan S, Achoui M, Abdulla MA, Mustafa MR, Ahmad S, Noordin MI, Yong CL (2012) In vitro and in vivo anti-inflammatory activities of columbin through the inhibition of cycloxygenase-2 and nitric oxide but not the suppression of NF-\u03baB translocation. Eur J Pharmacol 678:61\u201370","journal-title":"Eur J Pharmacol"},{"key":"438_CR2","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1155\/2012\/270383","volume":"2012","author":"S Anuchapreeda","year":"2012","unstructured":"Anuchapreeda S, Fukumori Y, Okonogi S, Ichikawa H (2012) Preparation of lipid nanoemulsions incorporating curcumin for cancer therapy. J Nanotechnol 2012:11","journal-title":"J Nanotechnol"},{"key":"438_CR3","first-page":"64","volume":"3","author":"BS Badreddine","year":"2015","unstructured":"Badreddine BS, Olfa E, Samir D, Hnia C, Lahbib BJM (2015) Chemical composition of Rosmarinus officinalis and Lavandula stoechas essential oils and their insecticidal effects on Orgyia trigotephras (Lepidoptera: Lymantriidae). J Coast Life Med 3:64\u201369","journal-title":"J Coast Life Med"},{"key":"438_CR4","doi-asserted-by":"publisher","DOI":"10.1007\/s10787-017-0374-8","author":"RS Borges","year":"2017","unstructured":"Borges RS, Lima ES, Keita H, Ferreira IM, Fernandes CP, Cruz RAS, Duarte JL, Vel\u00e1zquez-Moyado J, Ortiz BLS, Castro NA, Ferreira JV, Hage-Melim LIS, Carvalho JCT (2017) Anti-inflammatory and antialgic actions of a nanoemulsion of Rosmarinus officinalis L. essential oil and a molecular docking study of its major chemical constituents. Inflammopharmacology. \n                    https:\/\/doi.org\/10.1007\/s10787-017-0374-8","journal-title":"Inflammopharmacology"},{"key":"438_CR5","unstructured":"British Pharmacopoeia (BP) (2009). The Office Stationery (TSO): British pharmacopoeia secretariat and medicines and healthcare products regulatory agency (MHRA), vol 1, London, England"},{"key":"438_CR6","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s10787-016-0302-3","volume":"25","author":"JCT Carvalho","year":"2017","unstructured":"Carvalho JCT, Keita H, Santana GR, Souza GC, Santos IVF, Amado JRR, Kourouma A, Prada AL, Carvalho HO, Silva ML (2017) Effects of Bothrops alternatus venom in zebrafish: a histopathological study. Inflammopharmacology 25:1\u201312","journal-title":"Inflammopharmacology"},{"key":"438_CR7","doi-asserted-by":"publisher","first-page":"553","DOI":"10.1016\/j.foodchem.2005.10.011","volume":"100","author":"OY Celiktas","year":"2007","unstructured":"Celiktas OY, Kocabas EEH, Bedir E, Sukan FV, Ozek T, Baser KHC (2007) Antimicrobial activities of methanol extracts and essential oils of Rosmarinus officinalis, depending on location and seasonal variations. Food Chem 100:553\u2013559","journal-title":"Food Chem"},{"key":"438_CR8","first-page":"e50691","volume":"78","author":"C Collymore","year":"2013","unstructured":"Collymore C, Rasmussen S, Tolwani RJ (2013) Gavaging adult zebrafish. J Vis Exp 78:e50691","journal-title":"J Vis Exp"},{"key":"438_CR9","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1097\/DER.0000000000000175","volume":"27","author":"AC Groot De","year":"2016","unstructured":"De Groot AC, Schmidt E (2016) Essential oils, part I. Dermatitis 27:39\u201342","journal-title":"Dermatitis"},{"key":"438_CR10","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1016\/j.bjp.2015.02.010","volume":"25","author":"JL Duarte","year":"2015","unstructured":"Duarte JL, Amado JRR, Oliveira AEMFM, Cruz RAS, Ferreira AM, Souto RNP, Falc\u00e3o DQ, Carvalho JCT, Fernandes CP (2015) Evaluation of larvicidal activity of a nanoemulsion of Rosmarinus officinalis essential oil. Revista Brasileira de Farmacognosia 25:189\u2013192","journal-title":"Revista Brasileira de Farmacognosia"},{"key":"438_CR11","doi-asserted-by":"publisher","first-page":"637","DOI":"10.1590\/S0101-20612007000300032","volume":"27","author":"AP Falc\u00e3o","year":"2007","unstructured":"Falc\u00e3o AP, Chaves ES, Kuskoski EM, Fett R, Falc\u00e3o DL, Bordignon-Luiz T (2007) \u00cdndice de polifen\u00f3is, antocianinas totais e atividade antioxidante de um sistema modelo de gel\u00e9ia de uvas. Ci\u00eanc Tecnol Aliment 27:637\u2013642","journal-title":"Ci\u00eanc Tecnol Aliment"},{"key":"438_CR12","first-page":"1","volume":"7","author":"LRD Faria","year":"2011","unstructured":"Faria LRD, Lima CS, Perazzo FF, Carvalho JCT (2011) Anti-inflammatory and antinociceptive activities of the essential oil from Rosmarinus Officinalis L. (Lamiaceae). Int J Pharm Sci Rev Res 7:1\u20138","journal-title":"Int J Pharm Sci Rev Res"},{"issue":"1","key":"438_CR13","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1590\/S0102-695X2012005000127","volume":"23","author":"CP Fernandes","year":"2013","unstructured":"Fernandes CP, Mascarenhas MP, Zibetti FM, Lima BG, Oliveira RPRF, Rocha L, Falc\u00e3o DQ (2013) HLB value, an important parameter for the development of essential oil phytopharmaceuticals. Braz J Pharmacogn 23(1):108\u2013114","journal-title":"Braz J Pharmacogn"},{"key":"438_CR14","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1007\/3-540-46545-6_8","volume":"115","author":"A Forgiarini","year":"2000","unstructured":"Forgiarini A, Esquena J, Gonz\u00e1lez C, Solans C (2000) Studies of the relation between phase behavior and emulsification methods with nanoemulsion formation. Progr Colloid Polym Sci 115:36\u201339","journal-title":"Progr Colloid Polym Sci"},{"key":"438_CR15","doi-asserted-by":"publisher","first-page":"7329","DOI":"10.3390\/molecules20047329","volume":"20","author":"IA Freires","year":"2015","unstructured":"Freires IA, Denny C, Benso B, de Alencar SM, Rosalen PL (2015) Antibacterial activity of essential oils and their isolated constituents against cariogenic bacteria: a systematic review. Molecules 20:7329\u20137358","journal-title":"Molecules"},{"key":"438_CR16","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1016\/0003-2697(82)90118-X","volume":"126","author":"LC Green","year":"1982","unstructured":"Green LC, Wagner DA, Glogowski J, Skipper PL, Wishnok JS, Tannenbaum SR (1982) Analyses of nitrate, nitrite and nitrate in biological fluids. Anal Biochem 126:131\u2013138","journal-title":"Anal Biochem"},{"key":"438_CR17","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1016\/j.foodchem.2015.01.048","volume":"178","author":"TVA Ha","year":"2015","unstructured":"Ha TVA, Kim S, Choi Y, Kwak HS, Lee SJ, Wen J, Oey I, Ko S (2015) Antioxidant activity and bioaccessibility of size-different nanoemulsions for lycopene-enriched tomato extract. Food Chem 178:115\u2013121","journal-title":"Food Chem"},{"key":"438_CR18","doi-asserted-by":"crossref","first-page":"2601","DOI":"10.14233\/ajchem.2013.13506","volume":"25","author":"K Hcini","year":"2013","unstructured":"Hcini K, Sotomayor JA, Jordan MJ, Bouzid S (2013) Chemical composition of the essential oil of Rosemary (Rosmarinus officinalis L.) of Tunisian origin. Asian J Chem 25:2601\u20132603","journal-title":"Asian J Chem"},{"key":"438_CR19","first-page":"58","volume-title":"The zebrafish: atlas of macroscopic and microscopic anatomy","author":"JA Holden","year":"2012","unstructured":"Holden JA, Layfield LL, Matthews JL (2012) The zebrafish: atlas of macroscopic and microscopic anatomy. Cambridge University Press, Cambridge, pp 58\u2013100"},{"key":"438_CR20","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1016\/j.carbpol.2013.02.031","volume":"95","author":"SF Hosseini","year":"2013","unstructured":"Hosseini SF, Zandi M, Rezaei M, Farahmandghavi F (2013) Two-step method for encapsulation of oregano essential oil in chitosan nanoparticles: preparation, characterization and in vitro release study. Carbohydr Polym 95:50\u201356. \n                    https:\/\/doi.org\/10.1016\/j.carbpol.2013.02.031","journal-title":"Carbohydr Polym"},{"key":"438_CR21","volume-title":"Gills","author":"DF Houlihan","year":"1982","unstructured":"Houlihan DF, Rankin JC, Shuttleworth TJ (1982) Gills. Cambridge University, Cambridge"},{"issue":"8","key":"438_CR22","doi-asserted-by":"publisher","first-page":"e104414","DOI":"10.1371\/journal.pone.0104414","volume":"9","author":"S-Y Huang","year":"2014","unstructured":"Huang S-Y, Feng C-W, Hung H-C, Chakraborty C, Chen C-H et al (2014) A novel zebrafish model to provide mechanistic insights into the inflammatory events in carrageenan-induced abdominal edema. PLoS ONE 9(8):e104414","journal-title":"PLoS ONE"},{"key":"438_CR23","first-page":"70","volume":"9","author":"MT Islam","year":"2016","unstructured":"Islam MT, Streck L, Paz MFCJ, Sousa JMC, Alencar MVOB, Mata AMOF, Carvalho RM, Santos JVO, Silva-Junior AA, Ferreira PMP, Melo-Cavalcante AAC (2016) Preparation of phytol-loaded nanoemulsion and screening for antioxidant capacity. Int Arch Med 9:70","journal-title":"Int Arch Med"},{"key":"438_CR24","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1016\/j.powtec.2014.11.006","volume":"271","author":"VY Ixtaina","year":"2015","unstructured":"Ixtaina VY, Julio LM, Wagner JR, Nolasco SM, Tom\u00e1s MC (2015) Physicochemical characterization and stability of chia oil microencapsulated with sodium caseinate and lactose by spray-drying. Powder Technol 271:26\u201334. \n                    https:\/\/doi.org\/10.1016\/j.powtec.2014.11.006","journal-title":"Powder Technol"},{"key":"438_CR25","doi-asserted-by":"publisher","first-page":"638","DOI":"10.1055\/s-0034-1372609","volume":"64","author":"UR Juergens","year":"2014","unstructured":"Juergens UR (2014) Anti-inflammatory properties of the monoterpene 1.8-cineole: current evidence for co-medication in inflammatory airway diseases. Drug Res 64:638\u2013646","journal-title":"Drug Res"},{"key":"438_CR26","doi-asserted-by":"publisher","first-page":"250","DOI":"10.1053\/rmed.2003.1432","volume":"97","author":"UR Juerges","year":"2003","unstructured":"Juerges UR, Dethlefsen U, Steinkamp G, Gillissen A, Repges R, Vetter H (2003) Anti-inflammatory activity of 1.8-cineol (eucalyptol) in bronchial asthma: a double-blind placebo-controlled trial. Respir Med 97:250\u2013256","journal-title":"Respir Med"},{"key":"438_CR27","unstructured":"Junqueira LC, Carneiro J. (2013) Histologia B\u00e1sica: Texto e Atlas. Guanabara Koogan, S\u00e3o Paulo: 12\u00aa Ed"},{"key":"438_CR28","doi-asserted-by":"publisher","first-page":"390","DOI":"10.1186\/s12906-015-0896-9","volume":"15","author":"OR Justo","year":"2015","unstructured":"Justo OR, Simioni PU, Gabriel DL, Tamashiro WMSC, Rosa PTV, Moraes AM (2015) Evaluation of in vitro anti-inflammatory effects of crude ginger and rosemary extracts obtained through supercritical CO2 extraction on macrophage and tumor cell line: the influence of vehicle type. BMC Complement Altern Med 15:390","journal-title":"BMC Complement Altern Med"},{"key":"438_CR29","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/j.ijfoodmicro.2010.04.025","volume":"141","author":"TT Kao","year":"2010","unstructured":"Kao TT, Tu HC, Chang WN, Chen BH, Shi YY, Chang TC, Fu TF (2010) Grape seed extract inhibits the growth and pathogenicity of Staphylococcus aureus by interfering with dihydrofolate reductase activity and folate-mediated one-carbon metabolism. Int J Food Microbiol 141:17\u201327","journal-title":"Int J Food Microbiol"},{"key":"438_CR30","first-page":"512","volume-title":"Plantas medicinais no Brasil: Nativas e ex\u00f3ticas","author":"HE Lorenzi","year":"2002","unstructured":"Lorenzi HE, Matos FJA (2002) Plantas medicinais no Brasil: Nativas e ex\u00f3ticas. Instituto Plantarum de Estudos de Flora, Nova Odessa, p 512"},{"key":"438_CR31","first-page":"32","volume-title":"Rosmarinus officinalis. Monografia (Curso de Fitomedicina)","author":"VF Marchiori","year":"2004","unstructured":"Marchiori VF (2004) Rosmarinus officinalis. Monografia (Curso de Fitomedicina). Funda\u00e7\u00e3o Herbarium; Associa\u00e7\u00e3o Argentina de Fitomedicina, Argentina, p 32"},{"key":"438_CR32","doi-asserted-by":"publisher","first-page":"822","DOI":"10.1603\/ME10140","volume":"48","author":"M Martinez-Velazquez","year":"2011","unstructured":"Martinez-Velazquez M, Rosario-Cruz R, Castillo-Herrera G, Flores-Fernandez JM, Alvarez AH, Lugo-Cervantes E (2011) Acaricidal effect of essential oils from Lippia graveolens (Lamiales: Verbenaceae), Rosmarinus officinalis (Lamiales: Lamiaceae), and Allium sativum (Liliales: Liliaceae) against Rhipicephalus microplus (Acari: Ixodidae). J Med Entomol 48:822\u2013827","journal-title":"J Med Entomol"},{"key":"438_CR33","doi-asserted-by":"publisher","first-page":"338","DOI":"10.1038\/nprot.2010.201","volume":"6","author":"P Mathur","year":"2011","unstructured":"Mathur P, Lau B, Guo S (2011) Conditioned place preference behavior in zebrafish. Nat Protoc 6:338\u2013345","journal-title":"Nat Protoc"},{"key":"438_CR34","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1006\/enrs.2001.4315","volume":"88","author":"AF Mazon","year":"2002","unstructured":"Mazon AF, Cerqueira CCC, Fernandes MN (2002) Gill cellular changes induced by copper exposure in the South American tropical fish Prochilodus scrofa. Environ Res Sect 88:52\u201363","journal-title":"Environ Res Sect"},{"key":"438_CR35","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1080\/10408398.2011.559558","volume":"51","author":"DJ McClements","year":"2011","unstructured":"McClements DJ, Rao J (2011) Food-grade nanoemulsions: formulation, fabrication, properties, performance, biological fate, and potential toxicity. Crit Rev Food Sci Nutr 51:285\u2013330","journal-title":"Crit Rev Food Sci Nutr"},{"key":"438_CR36","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1155\/2016\/9545693","volume":"2016","author":"A Mekonnen","year":"2016","unstructured":"Mekonnen A, Yitayew B, Tesema A, Taddese S (2016) In vitro antimicrobial activity of essential oil of Thymus schimperi, Matricaria chamomilla, Eucalyptus globulus and Rosmarinus officinalis. Int J Microbiol 2016:8","journal-title":"Int J Microbiol"},{"key":"438_CR37","unstructured":"Meletti PC, Rocha O (2003) Avalia\u00e7\u00e3o da degrada\u00e7\u00e3o ambiental por meio de testes de toxicidade com sedimento e de an\u00e1lises histopatol\u00f3gicas em peixes. Tese (Doutorado em Ci\u00eancias da Engenharia Ambiental) do Programa de P\u00f3s-Gradua\u00e7\u00e3o em Ci\u00eancias da Engenharia Ambiental, Universidade de S\u00e3o Paulo. S\u00e3o Carlos, Brasil"},{"key":"438_CR38","doi-asserted-by":"publisher","first-page":"944","DOI":"10.1089\/jmf.2010.0159","volume":"14","author":"GAN Melo","year":"2011","unstructured":"Melo GAN, Grespan R, Fonseca JP, Farinha TO, Silva EL, Romero AL, Bersani A, Cuman RK (2011) Rosmarinus officinalis L. essential oil inhibits in vivo and in vitro leukocyte migration. J Med Food 14:944\u2013949","journal-title":"J Med Food"},{"key":"438_CR39","first-page":"211","volume":"26","author":"P Molyneux","year":"2004","unstructured":"Molyneux P (2004) The use of the stable free radical diphenylpicrylhydrazyl (DPPH) for estimating antioxidant activity. Songklanakarin J Sci Technol 26:211\u2013219","journal-title":"Songklanakarin J Sci Technol"},{"key":"438_CR40","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1016\/S0022-1759(97)00043-4","volume":"204","author":"GR Nakayama","year":"1997","unstructured":"Nakayama GR, Caton MC, Nova MP, Parandoosh Z (1997) Assessment of the Alamar blue assay for cellular growth and viability in vitro. J Immunol Methods 204:205\u2013208","journal-title":"J Immunol Methods"},{"key":"438_CR41","doi-asserted-by":"publisher","first-page":"1075","DOI":"10.1002\/cbdv.201400274","volume":"12","author":"EM Napoli","year":"2015","unstructured":"Napoli EM, Siracusa L, Saija A, Speciale A, Trombetta D, Tuttolomondo T, La Bella S, Licata M, Virga G, Leone R, Leto C, Rubino L, Ruberto G (2015) Wild sicilian rosemary: phytochemical and morphological screening and antioxidant activity evaluation of extracts and essential oils. Chem Biodivers 12:1075\u20131094","journal-title":"Chem Biodivers"},{"key":"438_CR42","doi-asserted-by":"publisher","first-page":"560","DOI":"10.1016\/j.jfda.2015.01.001","volume":"23","author":"D Natrajan","year":"2015","unstructured":"Natrajan D, Srinivasan S, Sundar K, Ravindran A (2015) Formulation of essential oil-loaded chitosanealginate nanocapsules. J Food Drug Anal 23:560\u2013568. \n                    https:\/\/doi.org\/10.1016\/j.jfda.2015.01.001","journal-title":"J Food Drug Anal"},{"key":"438_CR43","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1046\/j.1523-5378.2003.00146.x","volume":"8","author":"T Ohno","year":"2003","unstructured":"Ohno T, Kita M, Yamaoka Y, Imamura S, Yamamoto T, Mitsufuji S, Kodama T, Kashima K, Imanishi J (2003) Antimicrobial activity of essential oils against Helicobacter pylori. Helicobacter 8:207\u2013215","journal-title":"Helicobacter"},{"key":"438_CR44","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1016\/j.colsurfb.2013.08.038","volume":"113","author":"EF Oliveira","year":"2014","unstructured":"Oliveira EF, Paula HCB, Paula RCM (2014) Alginate\/cashew gum nanoparticles for essential oil encapsulation. Coll Surf B Biointerfaces 113:146\u2013151. \n                    https:\/\/doi.org\/10.1016\/j.colsurfb.2017.07.055","journal-title":"Coll Surf B Biointerfaces"},{"key":"438_CR45","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1016\/S0378-5173(02)00051-0","volume":"237","author":"LO Orafidiya","year":"2002","unstructured":"Orafidiya LO, Oladimeji FA (2002) Determination of the required HLB values of some essential oils. Int J Pharm 237:241\u2013249","journal-title":"Int J Pharm"},{"key":"438_CR46","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1016\/j.jcis.2012.07.089","volume":"388","author":"F Ostertag","year":"2012","unstructured":"Ostertag F, Weiss J, McClements DV (2012) Low-energy formation of edible nanoemulsions: factors influencing droplet size produced by emulsion phase inversion. J Colloid Interface Sci 388:95\u2013102","journal-title":"J Colloid Interface Sci"},{"key":"438_CR47","unstructured":"Petrillo TR (2012) Levamisol e Dexametasona na Inflama\u00e7\u00e3o Cr\u00f4nica por Corpo Estranho em Pacu (piaractus Mesopotamicus). 84f. Disserta\u00e7\u00e3o (Mestrado em Medicina Veterin\u00e1ria) Faculdade de Ci\u00eancias Agr\u00e1rias e Veterin\u00e1rias, Universidade Estadual Paulista, Campus de Jaboticabal, S\u00e3o Paulo, Brasil"},{"key":"438_CR48","unstructured":"Pijpers J (2017) Encapsulation of essential oils with chitosan. A Master dissertation for the study programme Master in Drug Development. Dissertation, Ghent University, Belgium"},{"key":"438_CR49","first-page":"339","volume-title":"Sublethal and chronic effects of pollutants on freshwater fish","author":"V Poleksic","year":"1994","unstructured":"Poleksic V, Mitrovic-Tutundzic V (1994) Fish gills as a monitor of sublethal and chronic effects of pollution. In: M\u00fcller R, Lloyd R (eds) Sublethal and chronic effects of pollutants on freshwater fish. Fishing New Books ltd., Farnham pp, pp 339\u2013352"},{"key":"438_CR50","doi-asserted-by":"publisher","first-page":"12347","DOI":"10.3390\/s120912347","volume":"12","author":"SN Rampersad","year":"2012","unstructured":"Rampersad SN (2012) Multiple applications of Alamar blue as an indicator of metabolic function and cellular health in cell viability bioassays. Sensors 12:12347\u201312360","journal-title":"Sensors"},{"key":"438_CR51","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1186\/1472-6882-14-225","volume":"14","author":"A Ra\u0161kovi\u0107","year":"2014","unstructured":"Ra\u0161kovi\u0107 A, Milanovi\u0107 I, Pavlovi\u0107 N, \u0106ebovi\u0107 T, Vukmirovi\u0107 S, Mikov M (2014) Antioxidant activity of rosemary (Rosmarinus officinalis L.) essential oil and its hepatoprotective potential. BMC Complement Altern Med 14:225","journal-title":"BMC Complement Altern Med"},{"key":"438_CR52","doi-asserted-by":"publisher","first-page":"1231","DOI":"10.1016\/S0891-5849(98)00315-3","volume":"26","author":"R Re","year":"1998","unstructured":"Re R, Pellegrini N, Proteggente A, Pannala A, Yang M, Rice-Evans C (1998) Antioxidant activity applying an improved ABTS radical cation decolorization assay. Free Radical Biol Med 26:1231\u20131237","journal-title":"Free Radical Biol Med"},{"key":"438_CR53","unstructured":"Ribeiro LC (2013) Investiga\u00e7\u00e3o do efeito ictiot\u00f3xico do extrato etanolico da raiz de Spilanthes acmella (jambu) em zebrafish atrav\u00e9s da an\u00e1lise eletrofisiol\u00f3gica e comportamental. 61 f. Disserta\u00e7\u00e3o (Mestrado) Programa de P\u00f3s-Gradua\u00e7\u00e3o em Neuroci\u00eancias e Biologia Celular da Universidade Federal do Par\u00e1, Instituto de Ci\u00eancias Biol\u00f3gicas, Bel\u00e9m, Brasil"},{"key":"438_CR54","unstructured":"Rigolin-S\u00e1 O (1998) Toxicidade do herbicida Roundup (glifosato) e do acaricida Omite (propargito) nas fases iniciais da ontogenia do bagre, Rhandia hilarii (Valenciennes, 1840) (Pimelodidade, Siluriformes). 307f. Tese (Doutorado em Recursos Naturais) Curso de P\u00f3s-gradua\u00e7\u00e3o em Ecologia e Recursos Naturais, Universidade Federal de S\u00e3o Carlos, S\u00e3o Paulo, Brasil"},{"key":"438_CR55","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1016\/j.ijbiomac.2015.03.003","volume":"79","author":"MC Rivera","year":"2015","unstructured":"Rivera MC, Pinheiro AC, Bourbon AI, Cerqueira MA, Vicente AA (2015) Hollow chitosan\/alginate nanocapsules for bioactive compound delivery. Int J Biol Macromol 79:95\u2013102. \n                    https:\/\/doi.org\/10.1016\/j.ijbiomac.2015.03.003","journal-title":"Int J Biol Macromol"},{"key":"438_CR56","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1002\/9781118222942","volume-title":"Fish pathology","author":"RJ Roberts","year":"2012","unstructured":"Roberts RJ, Ellis AE (2012) The anatomy and physiology of teleosts. In: Roberts RJ (ed) Fish pathology, 3rd edn. W. B. Saunders, Philadelphia, pp 12\u201354","edition":"3"},{"key":"438_CR57","unstructured":"Rodrigues EL (1994) Altera\u00e7\u00f5es morfol\u00f3gicas em hemat\u00f3citos de Brachy danio rerio (Hamilton-Buchanan, 1822, 1823) exposto \u00e0 a\u00e7\u00e3o do organofosforado dimetoato 500 em dose subletal. (Disserta\u00e7\u00e3o). Mestrado em Biologia Celular, Universidade Federal do Paran\u00e1, Brasil"},{"key":"438_CR58","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1080\/10412905.2003.9712248","volume":"15","author":"S Salido","year":"2003","unstructured":"Salido S, Altarejos J, Nogueras M, Sa\u00e1nchez A, Luque P (2003) Chemical Composition and seasonal variations of rosemary oil from southern Spain. J Essent Oil Res 15:1","journal-title":"J Essent Oil Res"},{"key":"438_CR59","doi-asserted-by":"publisher","first-page":"240","DOI":"10.1002\/1099-1573(200006)14:4<240::AID-PTR573>3.0.CO;2-X","volume":"14","author":"FA Santos","year":"2000","unstructured":"Santos FA, Rao VSN (2000) Antiinflammatory and antinociceptive effects of 1,8-cineole a terpenoid oxide present in many plant essential oils. Phytother Res 14:240\u2013244","journal-title":"Phytother Res"},{"issue":"42","key":"438_CR60","doi-asserted-by":"publisher","first-page":"883","DOI":"10.5897\/AJPP2016.4662","volume":"10","author":"IVF Santos","year":"2016","unstructured":"Santos IVF, Duarte JL, Fernandes CP, Keita H, Amado JRR, Vel\u00e1zquez-Moyado JA, Navarrete A, Carvalho JCT (2016) Use of zebrafish (Danio rerio) in experimental models for biological assay with natural products. Afr J Pharm Pharmacol 10(42):883\u2013891","journal-title":"Afr J Pharm Pharmacol"},{"key":"438_CR61","doi-asserted-by":"publisher","first-page":"2609","DOI":"10.1007\/s11947-012-0911-9","volume":"6","author":"M Sessa","year":"2013","unstructured":"Sessa M, Casazza AA, Perego P, Tsao R, Ferrari G, Donsi F (2013) Exploitation of polyphenolic extracts from grape marc as natural antioxidants by encapsulation in lipid-based nanodelivery systems. Food Bioprocess Technol 6:2609\u20132620","journal-title":"Food Bioprocess Technol"},{"key":"438_CR62","volume-title":"Biometry: the principles and practice of statistics in biological research","author":"RR Sokal","year":"1995","unstructured":"Sokal RR, Rohlf FJ (1995) Biometry: the principles and practice of statistics in biological research, 3rd edn. WH Freeman and Company, New York","edition":"3"},{"key":"438_CR63","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1016\/j.cocis.2005.06.004","volume":"10","author":"C Solans","year":"2005","unstructured":"Solans C, Izquierdo P, Nolla J, Azemar N, Garcia-Celma MJ (2005) Nano-emulsions. Curr Opin Colloid Interface Sci 10:102\u2013110","journal-title":"Curr Opin Colloid Interface Sci"},{"key":"438_CR64","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1016\/j.jcis.2012.02.063","volume":"376","author":"I Sol\u00e8","year":"2012","unstructured":"Sol\u00e8 I, Solans C, Maestro A, Gonz\u00e1lez C, Guti\u00e9rrez JM (2012) Study of nano-emulsion formation by dilution of microemulsions. J Colloid Interface Sci 376:133\u2013139","journal-title":"J Colloid Interface Sci"},{"issue":"4","key":"438_CR65","first-page":"93","volume":"4","author":"GC Souza","year":"2016","unstructured":"Souza GC, Duarte JL, Fernandes CP, Moyado JAV, Navarrete A, Carvalho JCT (2016) Obtainment and study of the toxicity of perillyl alcohol nanoemulsion on zebrafish (Danio rerio). J Nanomed Res 4(4):93","journal-title":"J Nanomed Res"},{"issue":"3","key":"438_CR66","first-page":"406","volume":"69","author":"F Takashima","year":"1984","unstructured":"Takashima F, Hibiya T (1984) An atlas of fish histology-normal and pathological features. Kodansha Ltd T\u00f3quio 69(3):406","journal-title":"Kodansha Ltd T\u00f3quio"},{"key":"438_CR67","unstructured":"Takashima F, Hibiya T (eds) (1995) An atlas of fish histology. In: Normal and pathogical features, 2nd edn. Kodansha Ltd, Tokyo"},{"key":"438_CR68","doi-asserted-by":"publisher","first-page":"677","DOI":"10.1016\/j.apjtb.2015.09.027","volume":"6","author":"C Takayama","year":"2016","unstructured":"Takayama C, De-Faria FM, Almeida ACA (2016) Chemical composition of Rosmarinus officinalis essential oil and antioxidant action against gastric damage induced by absolute ethanol in the rat. Asian Pac J Trop Biomed 6:677\u2013681","journal-title":"Asian Pac J Trop Biomed"},{"key":"438_CR69","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1016\/j.jsps.2016.06.004","volume":"25","author":"MC Teixeira","year":"2017","unstructured":"Teixeira MC, Severino P, Andreani T, Boonme P, Santini A, Silva AM, Souto EB (2017) D-a-tocopherol nanoemulsions: size properties, rheological behavior, surface tension, osmolarity and cytotoxicity. Saudi Pharm J 25:231\u2013235","journal-title":"Saudi Pharm J"},{"key":"438_CR70","doi-asserted-by":"publisher","first-page":"e22876","DOI":"10.1371\/journal.pone.0022876","volume":"6","author":"SL Tran","year":"2011","unstructured":"Tran SL, Puhar A, Ngo-Camus M, Ramarao N (2011) Trypan blue dye enters viable cells incubated with the pore-forming toxin HlyII of Bacillus cereus. PLoS ONE 6:e22876","journal-title":"PLoS ONE"},{"key":"438_CR71","first-page":"27","volume":"6","author":"N T\u00fcrkmen","year":"2014","unstructured":"T\u00fcrkmen N, \u00d6za A, S\u00f6nmeza A, Erola T, G\u00fcl\u00fcmsera D, Yurdakula B, Kay\u0131ra O, Elmastasa M, Erenler R (2014) Chemical composition of essential oil from Rosmarinus Officinalis L. Leaves. J New Results Sci 6:27\u201331","journal-title":"J New Results Sci"},{"key":"438_CR72","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1007\/s11010-009-0263-6","volume":"336","author":"N Verma","year":"2009","unstructured":"Verma N, Tripathi SK, Sahu D, Das HR, Das RH (2009) Evaluation of inhibitory activities of plant extracts on production of LPS-stimulated pro-inflammatory mediators in J774 murine macrophages. Mol Cell Biochem 336:127","journal-title":"Mol Cell Biochem"},{"key":"438_CR73","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1016\/j.jep.2013.03.016","volume":"147","author":"YM Wang","year":"2013","unstructured":"Wang YM, Xu M, Wang D, Yang CR, Zeng Y, Zhang YJ (2013) Anti-inflammatory compounds of \u201cqin-Jiao\u2016\u201d, the roots of Gentiana dahurica (Gentianaceae). J Ethnopharmacol 147:341\u2013348","journal-title":"J Ethnopharmacol"},{"key":"438_CR74","doi-asserted-by":"publisher","first-page":"8896","DOI":"10.1021\/jf0715166","volume":"55","author":"KL Wolfe","year":"2007","unstructured":"Wolfe KL, Liu RH (2007) Cellular antioxidant activity (CAA) assay for assessing antioxidants, foods, and dietary supplements. J Agric Food Chem 55:8896\u20138907","journal-title":"J Agric Food Chem"},{"key":"438_CR75","doi-asserted-by":"publisher","first-page":"2390","DOI":"10.3390\/molecules19022390","volume":"19","author":"LL Yang","year":"2014","unstructured":"Yang LL, Wang GQ, Yang LM, Huang ZB, Zhang, Yu LZ (2014) Endotoxin molecule lipopolysaccharide- induced zebrafish inflammation model: a novel screening method for anti-inflammatory drugs. Molecules 19:2390\u20132409","journal-title":"Molecules"}],"container-title":["Inflammopharmacology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10787-017-0438-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10787-017-0438-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10787-017-0438-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,2,4]],"date-time":"2019-02-04T20:08:28Z","timestamp":1549310908000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10787-017-0438-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,2,5]]},"references-count":75,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2018,8]]}},"alternative-id":["438"],"URL":"https:\/\/doi.org\/10.1007\/s10787-017-0438-9","relation":{},"ISSN":["0925-4692","1568-5608"],"issn-type":[{"value":"0925-4692","type":"print"},{"value":"1568-5608","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,2,5]]},"assertion":[{"value":"5 November 2017","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 December 2017","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 February 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"This article does not contain any studies with human participants, but with animals (Zebrafish - Danio rerio) that was approved by the Ethics Committee of the Amap\u00e1 Federal University.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}]}}