{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T03:33:14Z","timestamp":1787974394967,"version":"build-2784847793"},"reference-count":70,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2018,1,11]],"date-time":"2018-01-11T00:00:00Z","timestamp":1515628800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Inflammopharmacol"],"published-print":{"date-parts":[[2019,4]]},"DOI":"10.1007\/s10787-018-0441-9","type":"journal-article","created":{"date-parts":[[2018,1,11]],"date-time":"2018-01-11T15:31:46Z","timestamp":1515684706000},"page":"323-338","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Persea americana Mill. crude extract exhibits antinociceptive effect on UVB radiation-induced skin injury in mice"],"prefix":"10.1007","volume":"27","author":[{"given":"Viviane C. K. N.","family":"Deuschle","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Indiara","family":"Brusco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariana","family":"Piana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrique","family":"Faccin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leandro Machado","family":"de Carvalho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2960-5284","authenticated-orcid":false,"given":"Sara Marchesan","family":"Oliveira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carine","family":"Viana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,1,11]]},"reference":[{"key":"441_CR1","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1016\/S0367-326X(02)00118-1","volume":"73","author":"OO Adeyemi","year":"2002","unstructured":"Adeyemi OO, Okpo SO, Ogunti OO (2002) Analgesic and anti- inflammatory effects of the aqueous extract of leaves of Persea americana Mill Lauraceae. Fitoterapia 73:375\u2013380","journal-title":"Fitoterapia"},{"key":"441_CR2","doi-asserted-by":"publisher","first-page":"1384","DOI":"10.4067\/S0717-95022011000400053","volume":"29","author":"JO Adisa","year":"2011","unstructured":"Adisa JO, Ajayi Y, Egbujo EC (2011) Histopathologic effect of Persea americana aqueous leaves extract on the liver and kidney of weaner rabbits (California Species). Int J Morphol 29:1384\u20131387. \n                    https:\/\/doi.org\/10.4067\/S0717-95022011000400053","journal-title":"Int J Morphol"},{"key":"441_CR3","doi-asserted-by":"publisher","first-page":"253","DOI":"10.3892\/or.2012.2083","volume":"29","author":"IS An","year":"2013","unstructured":"An IS, An S, Park S, Lee SN, Bae S (2013) Involvement of microRNAs in epigallocatechin gallate-mediated UVB protection in human dermal fibroblasts. Oncol Rep 29:253\u2013259. \n                    https:\/\/doi.org\/10.3892\/or.2012.2083","journal-title":"Oncol Rep"},{"key":"441_CR4","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/j.pain.2008.02.028","volume":"139","author":"MS Angst","year":"2008","unstructured":"Angst MS, Clark JD, Carvalho B, Tingle M, Schmelz M, Yeomans DC (2008) Cytokine profile in human skin in response to experimental inflammation, noxious stimulation, and administration of a COX-inhibitor: a microdialysis study. Pain 139:15\u201327. \n                    https:\/\/doi.org\/10.1016\/j.pain.2008.02.028","journal-title":"Pain"},{"key":"441_CR5","doi-asserted-by":"publisher","first-page":"325","DOI":"10.4103\/0253-7613.16858","volume":"37","author":"BS Anita","year":"2005","unstructured":"Anita BS, Okokon JE, Okon PA (2005) Hypoglycemic activity of aqueous leaf extract of Persea americana Mill. Indian J Pharmacol 37:325\u2013326","journal-title":"Indian J Pharmacol"},{"key":"441_CR6","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1590\/s2175-97902017000215249","volume":"53","author":"PO Arantes","year":"2017","unstructured":"Arantes PO, Santos QN, Freitas ZMF, Pyrrho AS, Coutinho CC, Villa ALV, Santos EP, Ricci-J\u00fanior E (2017) Promotion of cutaneous penetration of nifedipine for nanoemulsion. Braz J Pharm Sci 53:1\u201312. \n                    https:\/\/doi.org\/10.1590\/s2175-97902017000215249","journal-title":"Braz J Pharm Sci"},{"key":"441_CR7","doi-asserted-by":"publisher","first-page":"524","DOI":"10.1016\/j.ejpain.2008.06.006","volume":"13","author":"T Bishop","year":"2009","unstructured":"Bishop T, Ballard A, Holmes H, Young AR, McMahon SB (2009) Ultraviolet-B induced inflammation of human skin: characterisation and comparison with traditional models of hyperalgesia. Eur J Pain 13:524\u2013532. \n                    https:\/\/doi.org\/10.1016\/j.ejpain.2008.06.006","journal-title":"Eur J Pain"},{"key":"441_CR8","unstructured":"Boelter R (2010) Plantas medicinais usadas na medicina veterin\u00e1ria, second ed. 2010. Santa Maria: Andrei, p 320"},{"key":"441_CR9","doi-asserted-by":"publisher","first-page":"206","DOI":"10.1111\/1523-1747.ep12506462","volume":"78","author":"PP Bradley","year":"1982","unstructured":"Bradley PP, Priebat DA, Christensen RD, Rothstein G (1982) Measurement of cutaneous inflammation: estimation of neutrophil content with an enzyme marker. J Invest Dermatol 78:206\u2013209","journal-title":"J Invest Dermatol"},{"key":"441_CR10","unstructured":"Brazil (2004) National agency of sanitary vigilance. Brazilian cosmetic products stability guide. 1 edn. Bras\u00edlia"},{"key":"441_CR11","doi-asserted-by":"publisher","first-page":"S114","DOI":"10.1016\/j.jaad.2011.05.033","volume":"65","author":"DB Buller","year":"2011","unstructured":"Buller DB, Cokkinides V, Hall HI, Hartman AM, Saraiya M, Miller E, Paddock L, Glanz K (2011) Prevalence of sunburn, sun protection, and indoor tanning behaviors among Americans: review from national surveys and case studies of 3 states. J Am Acad Dermatol 65:S114\u2013S123. \n                    https:\/\/doi.org\/10.1016\/j.jaad.2011.05.033","journal-title":"J Am Acad Dermatol"},{"key":"441_CR12","doi-asserted-by":"publisher","first-page":"136","DOI":"10.4062\/biomolther.2014.006","volume":"22","author":"JW Cha","year":"2014","unstructured":"Cha JW, Piao MJ, Kim KC, Yao CW, Zheng J, Kim SM, Hyun CL, Ahn YS, Hyun JW (2014) The polyphenol chlorogenic acid attenuates UVB-mediated oxidative stress in human HaCaT keratinocytes. Biomol Ther (Seoul) 22:136\u2013142. \n                    https:\/\/doi.org\/10.4062\/biomolther.2014.006","journal-title":"Biomol Ther (Seoul)"},{"key":"441_CR13","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1016\/j.abb.2014.05.016","volume":"559","author":"K Choi","year":"2014","unstructured":"Choi K, Kundu JK, Chun KS, Na HK, Surh YJ (2014) Rutin inhibits UVB radiation-induced expression of COX-2 and iNOS in hairless mouse skin: p38 MAP kinase and JNK as potential targets. Arch Biochem Biophys 559:38\u201345. \n                    https:\/\/doi.org\/10.1016\/j.abb.2014.05.016","journal-title":"Arch Biochem Biophys"},{"key":"441_CR14","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1128\/CMR.19.2.403-434.2006","volume":"19","author":"D Church","year":"2006","unstructured":"Church D, Elsayed S, Reid O, Winston B, Lindsay R (2006) Burn wound infections. Clin Microbiol Rev 19:403\u2013434. \n                    https:\/\/doi.org\/10.1128\/CMR.19.2.403-434.2006","journal-title":"Clin Microbiol Rev"},{"key":"441_CR15","first-page":"777","volume-title":"Dicion\u00e1rio de plantas \u00fateis do Brasil e das ex\u00f3ticas cultivadas","author":"MP Corr\u00eaa","year":"1984","unstructured":"Corr\u00eaa MP (1984) Dicion\u00e1rio de plantas \u00fateis do Brasil e das ex\u00f3ticas cultivadas, vol 6. IBDF\/MA, Bras\u00edlia, p 777"},{"key":"441_CR16","doi-asserted-by":"publisher","first-page":"386","DOI":"10.1016\/j.semcancer.2007.04.003","volume":"17","author":"H Ding","year":"2007","unstructured":"Ding H, Chin YW, Kinghorn AD, D\u2019Ambrosio SM (2007) Chemopreventive characteristics of avocado fruit. Semin Cancer Biol 17:386\u2013394. \n                    https:\/\/doi.org\/10.1016\/j.semcancer.2007.04.003","journal-title":"Semin Cancer Biol"},{"key":"441_CR17","doi-asserted-by":"publisher","first-page":"441","DOI":"10.1146\/annurev.pa.20.040180.002301","volume":"20","author":"WJ Dixon","year":"1980","unstructured":"Dixon WJ (1980) Efficent analysis of experimental observations. Ann Rev Pharmacol Toxicol 20:441\u2013462. \n                    https:\/\/doi.org\/10.1146\/annurev.pa.20.040180.002301","journal-title":"Ann Rev Pharmacol Toxicol"},{"key":"441_CR18","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1016\/j.chroma.2015.12.017","volume":"1427","author":"H Faccin","year":"2016","unstructured":"Faccin H, Viana C, Nascimento PC, Bohrer D, Carvalho LM (2016) Study of ion suppression for phenolic compounds in medicinal plant extracts using liquid chromatography-electrospray tandem mass spectrometry. J Chromatogr 1427:111\u2013124. \n                    https:\/\/doi.org\/10.1016\/j.chroma.2015.12.017","journal-title":"J Chromatogr"},{"key":"441_CR19","doi-asserted-by":"publisher","first-page":"1141","DOI":"10.1039\/C6AY02937J","volume":"9","author":"H Faccin","year":"2017","unstructured":"Faccin H, Loose RF, Viana C, Lameira OA, Carvalho LM (2017) Determination of phenolic compounds in extracts of Amazonian medicinal plants by liquid chromatography-electrospray tandem mass spectrometry. Anal Methods 9:1141\u20131151. \n                    https:\/\/doi.org\/10.1039\/c6ay02937j","journal-title":"Anal Methods"},{"key":"441_CR20","doi-asserted-by":"publisher","first-page":"2993","DOI":"10.1042\/BCJ20170008","volume":"474","author":"MFP Fialho","year":"2017","unstructured":"Fialho MFP, Brusco I, da Silva Brum E, Piana M, Boligon AA, Trevisan G, Oliveira SM (2017) Buddleja thyrsoides Lam. crude extract presents antinociceptive effect on an arthritic pain model in mice. Biochem J. 474:2993\u20133010. \n                    https:\/\/doi.org\/10.1042\/BCJ20170008","journal-title":"Biochem J."},{"key":"441_CR21","unstructured":"Figueiredo BK, Martini PC, Michelin DC (2014) Desenvolvimento estabilidade preliminar de um fitocosm\u00e9tico contendo extrato de ch\u00e1 verde (Camellia sinensis) (L.) Kuntze (Theaceae). Rev Bras Farm 95,770-788"},{"key":"441_CR22","first-page":"558","volume":"26","author":"M Friedrich","year":"2007","unstructured":"Friedrich M, Primo FT, Funck JAB, Laporta LV, Alves MP, Bittencourt CF, Escarrone ALV (2007) Avalia\u00e7\u00e3o da estabilidade f\u00edsico-qu\u00edmica de creme n\u00e3o i\u00f4nico inscrito no Formul\u00e1rio Nacional. Acta Farm Bonaer 26:558\u2013562","journal-title":"Acta Farm Bonaer"},{"key":"441_CR23","doi-asserted-by":"publisher","first-page":"464","DOI":"10.1097\/BCR.0b013e3181a28c9b","volume":"30","author":"FW Fuller","year":"2009","unstructured":"Fuller FW (2009) The side effects of silver sulfadiazine. J Burn Care Res 30:464\u2013470. \n                    https:\/\/doi.org\/10.1097\/BCR.0b013e3181a28c9b","journal-title":"J Burn Care Res"},{"key":"441_CR24","first-page":"188","volume":"11","author":"AR Gaby","year":"2006","unstructured":"Gaby AR (2006) Natural remedies for scleroderma. Altern Med Rev 11:188\u2013195","journal-title":"Altern Med Rev"},{"key":"441_CR25","doi-asserted-by":"publisher","first-page":"1267","DOI":"10.1016\/j.burns.2014.07.024","volume":"40","author":"GAS Genuino","year":"2014","unstructured":"Genuino GAS, Baluyut-Angeles KV, Espiritu APT, Lapitan MCM, Buckley BS (2014) Topical petrolatum gel alone versus topical silver sulfadiazine with standard gauze dressings for the treatment of superficial partial thickness burns in adults: a randomized-controlled trial. Burns 40:1267\u20131273. \n                    https:\/\/doi.org\/10.1016\/j.burns.2014.07.024","journal-title":"Burns"},{"key":"441_CR26","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1590\/S1984-82502009000100002","volume":"45","author":"GMS Gon\u00e7alves","year":"2009","unstructured":"Gon\u00e7alves GMS, Campos PMBGM (2009) Aplica\u00e7\u00e3o de m\u00e9todos de biof\u00edsica no estudo da efic\u00e1cia de produtos dermocosm\u00e9ticos. Braz J Pharm Sci 45:1\u201310. \n                    https:\/\/doi.org\/10.1590\/s1984-82502009000100002","journal-title":"Braz J Pharm Sci"},{"key":"441_CR27","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1016\/j.ijpharm.2006.07.015","volume":"327","author":"T Guaratini","year":"2006","unstructured":"Guaratini T, Gianeti MD, Campos PMBGM (2006) Stability of cosmetic formulations containing esters of Vitamins E and A: chemical and physical aspects. Int J Pharmaceut 327:12\u201316. \n                    https:\/\/doi.org\/10.1016\/j.ijpharm.2006.07.015","journal-title":"Int J Pharmaceut"},{"key":"441_CR28","doi-asserted-by":"publisher","first-page":"586","DOI":"10.1016\/j.pain.2012.12.020","volume":"154","author":"A Gustorff","year":"2013","unstructured":"Gustorff A, Sycha T, Lieba-Samal D, Rolke R, Treede RD, Magerl W (2013) The pattern and time course of somatosensory changes in the human UVB sunburn model reveal the presence of peripheral and central sensitization. Pain 154:586\u2013597. \n                    https:\/\/doi.org\/10.1016\/j.pain.2012.12.020","journal-title":"Pain"},{"key":"441_CR29","doi-asserted-by":"publisher","first-page":"481","DOI":"10.1016\/S0031-9422(00)00235-1","volume":"55","author":"JB Harborne","year":"2000","unstructured":"Harborne JB, Williams CA (2000) Advances in flavonoid research since 1992. Phytochemistry 55:481\u2013504. \n                    https:\/\/doi.org\/10.1016\/S0031-9422(00)00235-1","journal-title":"Phytochemistry"},{"key":"441_CR30","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1046\/j.0022-202X.2003.22119.x","volume":"122","author":"GI Harrison","year":"2004","unstructured":"Harrison GI, Young AR, McMahon SB (2004) Ultraviolet radiation-induced inflammation as a model for cutaneous hyperalgesia. J Invest Dermatol 122:183\u2013189. \n                    https:\/\/doi.org\/10.1046\/j.0022-202X.2003.22119.x","journal-title":"J Invest Dermatol"},{"key":"441_CR31","doi-asserted-by":"publisher","first-page":"654","DOI":"10.1016\/j.lfs.2010.02.017","volume":"86","author":"K Hirao","year":"2010","unstructured":"Hirao K, Yumoto H, Nakanishi T, Mukai K, Takahashi K, Takegawa D, Matsuo T (2010) Tea catechins reduce inflammatory reactions via mitogen-activated protein kinase pathways in toll-like receptor 2 ligand-stimulated dental pulp cells. Life Sci 86:654\u2013660. \n                    https:\/\/doi.org\/10.1016\/j.lfs.2010.02.017","journal-title":"Life Sci"},{"key":"441_CR32","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1007\/s12010-011-9413-x","volume":"166","author":"YH Hong","year":"2012","unstructured":"Hong YH, Jung EY, Shin KS, Kim TY, Yu KW, Chang UJ, Suh HJ (2012) Photoprotective effects of a formulation containing tannase-converted green tea extract against UVB-induced oxidative stress in hairless mice. Appl Biochem Biotechnol 166:165\u2013175. \n                    https:\/\/doi.org\/10.1007\/s12010-011-9413-x","journal-title":"Appl Biochem Biotechnol"},{"key":"441_CR33","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/7368797","author":"YH Hong","year":"2016","unstructured":"Hong YH, Huang YL, Liu YC, Tsai PJ (2016) Djulis (Chenopodium formosanum Koidz.) water extract and its bioactive components ameliorate dermal damage in UVB-irradiated skin models. Biomed Res. \n                    https:\/\/doi.org\/10.1155\/2016\/7368797","journal-title":"Biomed Res"},{"key":"441_CR34","doi-asserted-by":"publisher","first-page":"1845","DOI":"10.3390\/12081845","volume":"12","author":"CC Huang","year":"2007","unstructured":"Huang CC, Wu WB, Fang JY, Chiang HS, Chen SK, Chen BH, Chen YT, Hung CF (2007) (\u2212)-Epicatechin-3-gallate, a green tea polyphenol is a potent agent against UVB-induced damage in HaCaT keratinocytes. Molecules 12:1845\u20131858","journal-title":"Molecules"},{"key":"441_CR35","first-page":"81","volume":"29","author":"VLB Isaac","year":"2008","unstructured":"Isaac VLB, Cefali LC, Chiari BG, Oliveira CCLG, Salgado HRN, Corr\u00eaa MA (2008) Protocolo para ensaios f\u00edsico-qu\u00edmicos de estabilidade de fitocosm\u00e9ticos. Rev Cienc Farm B\u00e1sica Apl 29:81\u201396","journal-title":"Rev Cienc Farm B\u00e1sica Apl"},{"key":"441_CR36","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1016\/j.foodchem.2016.10.051","volume":"221","author":"P Jim\u00e9nez","year":"2017","unstructured":"Jim\u00e9nez P, Garc\u00eda P, Bustamante A, Barriga A, Robert P (2017) Thermal stability of oils added with avocado (Persea americana cv. Hass) or olive (Olea europaea cv. Arbequina) leaf extracts during the French potatoes frying. Food Chem 221:123\u2013129. \n                    https:\/\/doi.org\/10.1016\/j.foodchem.2016.10.051","journal-title":"Food Chem"},{"key":"441_CR37","doi-asserted-by":"publisher","first-page":"587","DOI":"10.1007\/s00595-008-3944-y","volume":"39","author":"G Khorasani","year":"2009","unstructured":"Khorasani G, Hosseinimehr SJ, Azadbakht M, Zamani A, Mahdavi MR (2009) Aloe versus silver sulfadiazine creams for second-degree burns: a randomized controlled study. Surg Today 39:587\u2013591. \n                    https:\/\/doi.org\/10.1007\/s00595-008-3944-y","journal-title":"Surg Today"},{"key":"441_CR38","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1159\/000084912","volume":"18","author":"JL Kienzler","year":"2005","unstructured":"Kienzler JL, Magnette J, Queille-Roussel C, Sanchez-Ponton A, Ortonne JP (2005) Diclofenac-Na gel is effective in reducing the pain and inflammation associated with exposure to ultraviolet light\u2014results of two clinical studies. Skin Pharmacol Physiol 18:144\u2013152. \n                    https:\/\/doi.org\/10.1159\/000084912","journal-title":"Skin Pharmacol Physiol"},{"key":"441_CR39","doi-asserted-by":"publisher","first-page":"813","DOI":"10.1016\/j.burns.2012.03.011","volume":"38","author":"Z Koc","year":"2012","unstructured":"Koc Z, Sa\u011flam Z (2012) Burn epidemiology and cost of medicationin pediatric burn patients. Burns 38:813\u2013819. \n                    https:\/\/doi.org\/10.1016\/j.burns.2012.03.011","journal-title":"Burns"},{"key":"441_CR40","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1007\/s10600-010-9655-9","volume":"46","author":"K Larijani","year":"2010","unstructured":"Larijani K, Rustaiyan A, Azar PA, Nematollahi F, Taban S (2010) Composition of essential oil of leaves of Persea americana cultivated in Iran. Chem Nat Compd 46:489\u2013490. \n                    https:\/\/doi.org\/10.1007\/s10600-010-9655-9","journal-title":"Chem Nat Compd"},{"key":"441_CR41","doi-asserted-by":"publisher","first-page":"1681","DOI":"10.1016\/j.intimp.2008.08.002","volume":"8","author":"JH Lee","year":"2008","unstructured":"Lee JH, Park JH, Kim YS, Han Y (2008) Chlorogenic acid, a polyphenolic compound, treats mice with septic arthritis caused by Candida albicans. Int Immunopharmacol 8:1681\u20131685. \n                    https:\/\/doi.org\/10.1016\/j.intimp.2008.08.002","journal-title":"Int Immunopharmacol"},{"key":"441_CR42","doi-asserted-by":"publisher","first-page":"921","DOI":"10.1016\/j.foodchem.2011.11.067","volume":"132","author":"TH Lee","year":"2012","unstructured":"Lee TH, Tsai YF, Huang TT, Chen PC, Liang WL, Lee CK (2012) Heptadecanols from the leaves of Persea americana Mill. var. Am Food Chem 132:921\u2013924","journal-title":"Am Food Chem"},{"key":"441_CR43","doi-asserted-by":"publisher","first-page":"563","DOI":"10.1590\/S0365-05962002000500006","volume":"77","author":"GR Leonardi","year":"2002","unstructured":"Leonardi GR, Gaspar LR, Campos PMBGM (2002) Estudo da varia\u00e7\u00e3o do pH da pele humana exposta \u00e0 formula\u00e7\u00e3o cosm\u00e9tica acrescida ou n\u00e3o das vitaminas A, E ou de ceramida, por metodologia n\u00e3o invasiva. Ann Bras Dermatol 77:563\u2013569. \n                    https:\/\/doi.org\/10.1590\/S0365-05962002000500006","journal-title":"Ann Bras Dermatol"},{"key":"441_CR44","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1111\/cns.12444","volume":"22","author":"DM Lopes","year":"2016","unstructured":"Lopes DM, McMahon SB (2016) Ultraviolet radiation on the skin: a painful experience? CNS Neurosci Ther 22:118\u2013126. \n                    https:\/\/doi.org\/10.1111\/cns.12444","journal-title":"CNS Neurosci Ther"},{"key":"441_CR45","doi-asserted-by":"publisher","first-page":"352","DOI":"10.1111\/j.1755-5949.2008.00060.x","volume":"14","author":"AS Mandel","year":"2008","unstructured":"Mandel AS, Amit T, Weinreb O, Reznichenko L, Youdim MB (2008) Simultaneous manipulation of multiple brain targets by green tea catechins: a potential neuroprotective strategy for Alzheimer and Parkinson diseases. CNS Neurosci Ther 14:352\u2013365. \n                    https:\/\/doi.org\/10.1111\/j.1755-5949.2008.00060.x","journal-title":"CNS Neurosci Ther"},{"key":"441_CR46","doi-asserted-by":"publisher","first-page":"298","DOI":"10.1016\/j.taap.2003.08.019","volume":"195","author":"HN Matsumura","year":"2004","unstructured":"Matsumura HN (2004) Ananthaswamy, toxic effects of ultraviolet radiation on the skin. Toxicol Appl Pharmacol 195:298\u2013308. \n                    https:\/\/doi.org\/10.1016\/j.taap.2003.08.019","journal-title":"Toxicol Appl Pharmacol"},{"key":"441_CR47","doi-asserted-by":"publisher","first-page":"535","DOI":"10.1111\/j.1600-0625.2012.01507.x","volume":"21","author":"Y Matsumoto-Okasaki","year":"2012","unstructured":"Matsumoto-Okasaki Y, Furuse M, Kajiya K (2012) Claudin-5 haploinsufficiencye exacerbates UVB-induced oedema formation by inducing lymphatic vessel leakage. Exp Dermatol 21: 535\u2013561. \n                    https:\/\/doi.org\/10.1111\/j.1600-0625.2012.01526.x","journal-title":"Exp Dermatol"},{"key":"441_CR48","doi-asserted-by":"publisher","first-page":"5512","DOI":"10.1158\/0008-5472.CAN-06-0218","volume":"66","author":"SM Meeran","year":"2006","unstructured":"Meeran SM, Mantena SK, Elmets CA, Katiyar SK (2006) (\u2212)-Epigallocatechin-3-gallate prevents photocarcinogenesis in mice through interleukin-12-dependent DNA repair. Cancer Res 66:5512\u20135520. \n                    https:\/\/doi.org\/10.1158\/0008-5472.CAN-06-0218","journal-title":"Cancer Res"},{"key":"441_CR49","first-page":"95","volume":"34","author":"EKS Melo","year":"2013","unstructured":"Melo EKS, Carvalho ALM, Borba VFC, Sousa GD, Tabosa MAM, Leal LB (2013) An\u00e1lise e estudo viscosim\u00e9trico de diferentes g\u00e9is de cetoprofeno 2.5%. Rev Ci\u00eanc Farm B\u00e1sica Apl 34:95\u201399","journal-title":"Rev Ci\u00eanc Farm B\u00e1sica Apl"},{"key":"441_CR50","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1016\/j.jaad.2010.06.014","volume":"66","author":"AC Miller","year":"2012","unstructured":"Miller AC, Rashid RM, Falzon L, Elamin EM, Zehtabchi S (2012) Silver sulfadiazine for the treatment of partial-thickness burns and venous stasis ulcers. J Am Acad Dermatol 66:159\u2013165. \n                    https:\/\/doi.org\/10.1016\/j.jaad.2010.06.014","journal-title":"J Am Acad Dermatol"},{"key":"441_CR51","first-page":"134","volume":"4","author":"E Nasiri","year":"2015","unstructured":"Nasiri E, Hosseinimehr SJ, Azadbakht M, Akbari J, Enayati-Fard R, Azizi S, Azadbakht M (2015) The healing effect of Arnebia euchroma ointment versus silver sulfadiazine on burn wounds in rat. World J Plast Surg 4:134\u2013144","journal-title":"World J Plast Surg"},{"key":"441_CR52","doi-asserted-by":"publisher","first-page":"123","DOI":"10.12968\/jowc.2008.17.3.28670","volume":"17","author":"BS Nayak","year":"2008","unstructured":"Nayak BS, Raju SS, Chalapathi RAV (2008) Wound healing activity of Persea americana(avocado) fruit: a preclinical study on rats. J Wound Care 17:123\u2013126. \n                    https:\/\/doi.org\/10.12968\/jowc.2008.17.3.28670","journal-title":"J Wound Care"},{"key":"441_CR53","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/472382","author":"AP Oliveira","year":"2013","unstructured":"Oliveira AP, Franco Ede S, Rodrigues BR, Cordeiro DP, de Melo RG, de Aquino CM, Maia MB (2013) Effect of semisolid formulation of Persea americana mill (avocado) oil on wound healing in rats. Evid Based Compl Alternat Med. \n                    https:\/\/doi.org\/10.1155\/2013\/472382","journal-title":"Evid Based Compl Alternat Med"},{"key":"441_CR54","doi-asserted-by":"publisher","first-page":"396","DOI":"10.1016\/j.pbb.2014.07.005","volume":"124","author":"SM Oliveira","year":"2014","unstructured":"Oliveira SM, Silva CR, Wentz AP, Paim GR, Correa MS, Bonacorso HG, Prudente AS, Otuki MF, Ferreira J (2014) Antinociceptive effect of 3-(4-fluorophenyl)-5-trifluoromethyl-1H-1-tosylpyrazole. A Celecoxib structural analog in models of pathological pain. Pharmacol Biochem Behav 124:396\u2013404. \n                    https:\/\/doi.org\/10.1016\/j.pbb.2014.07.005","journal-title":"Pharmacol Biochem Behav"},{"key":"441_CR55","doi-asserted-by":"publisher","first-page":"881","DOI":"10.1007\/s00424-016-1801-1","volume":"468","author":"SM Oliveira","year":"2016","unstructured":"Oliveira SM, Silva CR, Trevisan G, Villarinho JG, Cordeiro MN, Richardson M, Borges MH, Castro CJ Jr, Gomez MV, Ferreira J (2016) Antinociceptive effect of a novel armed spider peptide Tx3-5 in pathological pain models in mice. Pflugers Arch Eur J Physiol 468:881\u2013894. \n                    https:\/\/doi.org\/10.1007\/s00424-016-1801-1","journal-title":"Pflugers Arch Eur J Physiol"},{"key":"441_CR56","doi-asserted-by":"publisher","first-page":"1130","DOI":"10.5897\/JMPR09.429","volume":"4","author":"M Owolabi","year":"2010","unstructured":"Owolabi M, Jaja SI, Coker H (2010) Bioactivity of the phytoconstituents of the leaves of Persea americana. J Med Plants Res 4:1130\u20131135. \n                    https:\/\/doi.org\/10.5897\/JMPR09.429","journal-title":"J Med Plants Res"},{"key":"441_CR57","doi-asserted-by":"publisher","first-page":"458","DOI":"10.1016\/j.jep.2013.08.040","volume":"150","author":"M Piana","year":"2013","unstructured":"Piana M, Silva MA, Trevisan G, de Brum TF, Silva CR, Boligon AA, Oliveira SM, Zadra M, Hoffmeister C, Rossato MF, Tonello R, Laporta LV, de Freitas RB, Belke BV, da Jesus RS, Ferreira J, Athayde ML (2013) Antiinflammatory effects of Viola tricolor gel in a model of sunburn in rats and the gel stability study. J Ethnopharmacol 150:458\u2013465. \n                    https:\/\/doi.org\/10.1016\/j.jep.2013.08.040","journal-title":"J Ethnopharmacol"},{"key":"441_CR58","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1016\/j.jnutbio.2016.03.013","volume":"33","author":"FA Pinho-Ribeiro","year":"2016","unstructured":"Pinho-Ribeiro FA, Zarpelon AC, Mizokami SS, Borghi SM, Bordignon J, Silva RL, Cunha TM, Alves-Filho JC, Cunha FQ, Casagrande R, Verri WA (2016) The citrus flavonone naringenin reduces lipopolysaccharide-induced inflammatory pain and leukocyte recruitment by inhibiting NF-\u03baB activation. J Nutr Biochem 33:8\u201314. \n                    https:\/\/doi.org\/10.1016\/j.jnutbio.2016.03.013","journal-title":"J Nutr Biochem"},{"key":"441_CR59","doi-asserted-by":"publisher","first-page":"891","DOI":"10.1017\/S0007114512006071","volume":"110","author":"LE Rhodes","year":"2013","unstructured":"Rhodes LE, Darby G, Massey KA, Clarke KA, Dew TP, Farrar MD, Bennett S, Watson RE, Williamson G, Nicolaou A (2013) Oral green tea\u00a0catechin\u00a0metabolites are incorporated into human skin and protect against UV radiation-induced cutaneous inflammation in association with reduced production of pro-inflammatory eicosanoid 12-hydroxyeicosatetraenoic acid. Br J Nutr 110:891\u2013900. \n                    https:\/\/doi.org\/10.1017\/S0007114512006071","journal-title":"Br J Nutr"},{"key":"441_CR60","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1016\/j.ejpb.2015.03.020","volume":"93","author":"LA Rigo","year":"2015","unstructured":"Rigo LA, da Silva CR, de Oliveira SM, Cabreira TN, de Bona da Silva C, Ferreira FJ, Beck RC (2015) Nanoencapsulation of rice bran oil increases its protective effects against UVB radiation-induced skin injury in mice. Eur J Pharm Biopharm 93:11\u201317. \n                    https:\/\/doi.org\/10.1016\/j.ejpb.2015.03.020","journal-title":"Eur J Pharm Biopharm"},{"key":"441_CR61","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1038\/clpt.2010.221","volume":"89","author":"F Rijken","year":"2011","unstructured":"Rijken F, Bruijnzeel-Koomen CA (2011) Photoaged skin: the role of neutrophils, preventive measures, and potential pharmacological targets. Clin Pharmacol Ther 89:120\u2013124. \n                    https:\/\/doi.org\/10.1038\/clpt.2010.221","journal-title":"Clin Pharmacol Ther"},{"key":"441_CR62","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1007\/s00403-010-1088-6","volume":"303","author":"G Rosenblat","year":"2011","unstructured":"Rosenblat G, Meretski S, Segal J, Tarshis M, Schroeder A, Zanin-Zhorov A, Lion G, Ingber A, Hochberg M (2011) Polyhydroxylated fatty alcohols derived from avocado suppress inflammatory response and provide non-sunscreen protection against UV-induced damage in skin cells. Arch Dermatol Res 303:239\u2013246. \n                    https:\/\/doi.org\/10.1007\/s00403-010-1088-6","journal-title":"Arch Dermatol Res"},{"key":"441_CR63","first-page":"130","volume":"86","author":"H Rouhi-Boroujeni","year":"2015","unstructured":"Rouhi-Boroujeni H, Gharipour M, Mohammadizadeh F, Ahmadi S, Rafieian-kopaei M (2015) Systematic review on safety and drug interaction of herbal therapy in hyperlipidemia: a guide for internist. Acta Biom 86:130\u2013136","journal-title":"Acta Biom"},{"key":"441_CR64","doi-asserted-by":"publisher","first-page":"244","DOI":"10.1016\/j.jep.2013.08.035","volume":"150","author":"V Schlemper","year":"2013","unstructured":"Schlemper V, Schlemper SR, Zampirolo JA (2013) Antiedematogenic effects of the polar fractions of Persea cordata Mez. (Lauraceae)on microvascular extravasation in rat skin. J Ethnopharmacol 150:244\u2013251. \n                    https:\/\/doi.org\/10.1016\/j.jep.2013.08.035","journal-title":"J Ethnopharmacol"},{"key":"441_CR65","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1016\/j.jphotobiol.2014.02.019","volume":"133","author":"MA Silva","year":"2014","unstructured":"Silva MA, Trevisan G, Hoffmeister C, Rossato MF, Boligon AA, Walker CI, Klafke JZ, Oliveira SM, Silva CR, Athayde ML, Ferreira J (2014) Anti-inflammatory and antioxidant effects of Aloe saponaria Haw in a model of UVB-induced paw sunburn in rats. J Photochem Photobiol B Biol 133:47\u201354. \n                    https:\/\/doi.org\/10.1016\/j.jphotobiol.2014.02.019","journal-title":"J Photochem Photobiol B Biol"},{"key":"441_CR66","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1159\/000051729","volume":"203","author":"M St\u00fccker","year":"2001","unstructured":"St\u00fccker M, Memmel U, Hoffmann M, Hartung J, Altmeyer P (2001) Vitamin B12 cream containing avocado oil in the therapy of plaque psoriasis. Dermatology 203:141\u2013147","journal-title":"Dermatology"},{"key":"441_CR67","doi-asserted-by":"publisher","first-page":"258","DOI":"10.1124\/jpet.112.195909","volume":"343","author":"G Trevisan","year":"2012","unstructured":"Trevisan G, Rossato MF, Walker CIB, Klafke JZ, Rosa F, Oliveira SM, Tonello R, Guerra GP, Boligon AA, Zanon RB, Athayde ML (2012) Identification of the plant steroid \u03b1-spinasterol as a novel transient receptor potential vanilloid 1 antagonist with antinociceptive properties. J Pharmacol Exp Ther 343:258\u2013269. \n                    https:\/\/doi.org\/10.1124\/jpet.112.195909","journal-title":"J Pharmacol Exp Ther"},{"key":"441_CR68","doi-asserted-by":"publisher","first-page":"1193","DOI":"10.1016\/j.foodchem.2010.03.114","volume":"122","author":"W Wang","year":"2010","unstructured":"Wang W, Bostic TR, Gu L (2010) Antioxidant capacities, procyanidins and pigments in avocados of different strains and cultivars. Food Chem 122:1193\u20131198. \n                    https:\/\/doi.org\/10.1016\/j.foodchem.2010.03.114","journal-title":"Food Chem"},{"key":"441_CR69","doi-asserted-by":"publisher","first-page":"49","DOI":"10.4308\/hjb.19.1.49","volume":"19","author":"I Wientarsih","year":"2012","unstructured":"Wientarsih I, Madyastuti R, Prasetyo BF, Aldobrata A (2012) Anti lithiasis activity of avocado (Persea americana Mill) leaves extract in white male rats. HAYATI J Biosci 19:49\u201352","journal-title":"HAYATI J Biosci"},{"key":"441_CR70","doi-asserted-by":"publisher","first-page":"77","DOI":"10.4103\/0973-7847.65332","volume":"4","author":"M Yasir","year":"2010","unstructured":"Yasir M, Das S, Kharya MD (2010) The phytochemical and pharmacological profile of Persea americana Mill. Pharmacogn Ver 4:77\u201384. \n                    https:\/\/doi.org\/10.4103\/0973-7847.65332","journal-title":"Pharmacogn Ver"}],"container-title":["Inflammopharmacology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10787-018-0441-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10787-018-0441-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10787-018-0441-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,31]],"date-time":"2019-08-31T06:22:30Z","timestamp":1567232550000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10787-018-0441-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1,11]]},"references-count":70,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2019,4]]}},"alternative-id":["441"],"URL":"https:\/\/doi.org\/10.1007\/s10787-018-0441-9","relation":{},"ISSN":["0925-4692","1568-5608"],"issn-type":[{"value":"0925-4692","type":"print"},{"value":"1568-5608","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,1,11]]},"assertion":[{"value":"5 December 2017","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 January 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 January 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that there are no conflicts of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"All procedures performed were in accordance with international and national and were approved by Ethics Committee for Animal Research of the Federal University of Santa Maria (process number 1974200416\/2016).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}]}}