{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T10:55:13Z","timestamp":1793271313172,"version":"4.5.0"},"reference-count":73,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2018,6,13]],"date-time":"2018-06-13T00:00:00Z","timestamp":1528848000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"name":"ICCBS-TWAS","award":["RF No: 3240280477"],"award-info":[{"award-number":["RF No: 3240280477"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Inflammopharmacol"],"published-print":{"date-parts":[[2018,12]]},"DOI":"10.1007\/s10787-018-0505-x","type":"journal-article","created":{"date-parts":[[2018,6,13]],"date-time":"2018-06-13T04:19:16Z","timestamp":1528863556000},"page":"1383-1398","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Anti-inflammatory and anti-arthritic effects of methanol extract of the stem bark of Boswellia dalzielii Hutch (Burseraceae) in rats"],"prefix":"10.1007","volume":"26","author":[{"given":"Marius","family":"Mbiantcha","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jabeen","family":"Almas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Albert Donatien","family":"Atsamo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gilbert","family":"Ateufack","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simjee U.","family":"Shabana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Desire Francis","family":"Bomba Tatsinkou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Yousseu Nana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dastagir","family":"Nida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,6,13]]},"reference":[{"issue":"7","key":"505_CR1","doi-asserted-by":"publisher","first-page":"822","DOI":"10.1016\/S0367-326X(01)00313-6","volume":"72","author":"EA Adelakun","year":"2001","unstructured":"Adelakun EA, Finbar EAV, Agina SE, Makinde AA (2001) Antimicrobial activity of Boswellia dalzielii stem bark. Fitoterapia 72(7):822\u2013824","journal-title":"Fitoterapia"},{"key":"505_CR2","first-page":"108","volume":"10","author":"TE Alemika","year":"2006","unstructured":"Alemika TE, Onawunmi GO, Olugbade TO (2006) Antibacterial phenolics from Boswellia dalzielii. Niger J Nat Prod Med 10:108\u2013110","journal-title":"Niger J Nat Prod Med"},{"key":"505_CR3","doi-asserted-by":"publisher","first-page":"232","DOI":"10.1016\/j.intimp.2016.04.034","volume":"36","author":"J Almas","year":"2016","unstructured":"Almas J, Mesaik MA, Shabana US, Lubna SB, Shaheen F (2016) Anti-TNF-\u03b1 and antiarthritis of patuletin: a rare flavonoid from Tagetes patula. Int Immunopharmacol 36:232\u2013240","journal-title":"Int Immunopharmacol"},{"key":"505_CR4","doi-asserted-by":"publisher","first-page":"1321","DOI":"10.3390\/molecules21101321","volume":"21","author":"A Azab","year":"2016","unstructured":"Azab A, Nassar A, Azab AN (2016) Anti-inflammatory activity of natural products. Molecules 21:1321","journal-title":"Molecules"},{"key":"505_CR5","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1016\/j.biomag.2014.04.007","volume":"4","author":"GV Bihani","year":"2014","unstructured":"Bihani GV, Rojatkar SR, Bodhankar SL (2014) Anti-arthritic activity of methanol extract of Cyathocline purpurea (whole plant) in Freund\u2019s complete adjuvant-induced arthritis in rats. Biomed Aging Pathol 4:197\u2013206","journal-title":"Biomed Aging Pathol"},{"key":"505_CR6","first-page":"300","volume-title":"Useful plants of West Tropical Africa","author":"HM Burkill","year":"1985","unstructured":"Burkill HM (1985) Useful plants of West Tropical Africa, vol 1. White Friars Press Ltd., London, pp 300\u2013301"},{"key":"505_CR7","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1007\/s00210-006-0062-5","volume":"373","author":"X Cai","year":"2006","unstructured":"Cai X, Wong YF, Zhou H, Xie Y, Liu ZQ, Jiang ZH, Bian ZX, Xu H, Liu L (2006) The comparative study of Sprague Dawley and Lewis rats in adjuvant induced arthritis. Naunyn-Schmiedeberg\u2019s. Arch Pharmacol 373:140\u2013147","journal-title":"Arch Pharmacol"},{"key":"505_CR8","doi-asserted-by":"publisher","first-page":"15854","DOI":"10.1074\/jbc.M100010200","volume":"276","author":"A Castrillo","year":"2001","unstructured":"Castrillo A, De las Heras B, Hortelano S, Rodriguez B, Villar A, Boscar L (2001) Inhibition of the nuclear factor kappa B (NF-kappa B) pathway by tetracyclic kaurene diterpenes in macrophages. Specific effects on NF-kappa B-inducing kinase activity and on the coordinate activation of ERK and p38 MAPK. J Biol Chem 276:15854\u201315860","journal-title":"J Biol Chem"},{"issue":"1","key":"505_CR9","doi-asserted-by":"publisher","first-page":"070","DOI":"10.7324\/JAPS.2016.600112","volume":"6","author":"P Chandrasenan","year":"2016","unstructured":"Chandrasenan P, Neethu MV, Anjumol VM, Anandan V, Selvaraj R (2016) Triterpenoid fraction isolated from Euphorbia tirucalli Linn. Ameliorates collagen induced arthritis in Wistar rats. J App Pharm Sci 6(1):070\u2013075","journal-title":"J App Pharm Sci"},{"key":"505_CR10","doi-asserted-by":"publisher","DOI":"10.1093\/ecam\/nep027","author":"HY Chang","year":"2009","unstructured":"Chang HY, Sheu MJ, Yang CH, Lu TC, Chang YS, Peng WH, Huang SS, Huang GJ (2009) Analgesic effects and the mechanisms of anti-inflammation of hispolon in mice. J Evid Based Complement Altern Med. https:\/\/doi.org\/10.1093\/ecam\/nep027","journal-title":"J Evid Based Complement Altern Med"},{"issue":"6\u20137","key":"505_CR11","doi-asserted-by":"publisher","first-page":"544","DOI":"10.1078\/094471103322331520","volume":"10","author":"EJ Choi","year":"2003","unstructured":"Choi EJ, Yakozawa T, Rhyu DY, Kim SC, Shibahara N, Park JC (2003) Study on the inhibitory effects of Korean medicinal plants and their main compound on 1,1-diphenyl-2-picrylhydrazyl radical. Phytomedicine 10(6\u20137):544\u2013551","journal-title":"Phytomedicine"},{"key":"505_CR12","doi-asserted-by":"publisher","first-page":"611","DOI":"10.1124\/jpet.106.102806","volume":"318","author":"RF Claudino","year":"2006","unstructured":"Claudino RF, Kassuya CAL, Ferreira J, Calixto JB (2006) Pharmacological and molecular characterization of the mechanisms involved in prostaglandin E2-induced mouse paw edema. J Pharmacol Exp Ther 318:611\u2013618","journal-title":"J Pharmacol Exp Ther"},{"key":"505_CR13","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1016\/0024-3205(82)90402-7","volume":"31","author":"FC Colpaert","year":"1982","unstructured":"Colpaert FC, Meert T, Witte P, Schmitt P (1982) Further evidence validating adjuvant arthritis as an experimental model of chronic pain in the rat. Life Sci 31:67\u201375","journal-title":"Life Sci"},{"key":"505_CR14","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1016\/j.jep.2007.07.021","volume":"114","author":"M D\u00e9ciga-Campos","year":"2007","unstructured":"D\u00e9ciga-Campos M, Palacios-Espinosa JF, Reyes-Ram\u00edrez A, Mata R (2007) Antinociceptive and anti-inflammatory effects of compounds isolated from Scaphyglottis livida and Maxillaria densa. J Ethnopharmacol 114:161\u2013168","journal-title":"J Ethnopharmacol"},{"key":"505_CR15","first-page":"4607","volume":"4","author":"M Dhanalakshmi","year":"2012","unstructured":"Dhanalakshmi M, Jayasree T, Shaik S (2012) Antiarthritic activity of leaves of Michelia champaca 1 by complete freund\u2019s adjuvant. Int J Pharmacol Toxicol 4:4607\u20134615","journal-title":"Int J Pharmacol Toxicol"},{"key":"505_CR16","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1002\/path.1711040103","volume":"104","author":"M Rosa Di","year":"1971","unstructured":"Di Rosa M, Giroud JP, Willoughby DA (1971) Studies of mediators of the acute inflammatory response induced in rats in different sites by carrageenin and turpentine. J Pathol 104:15\u201329","journal-title":"J Pathol"},{"issue":"2","key":"505_CR17","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1080\/10412905.2006.9699038","volume":"18","author":"K Dimas","year":"2006","unstructured":"Dimas K, Ishaka AO, Domingo AO, Nureni OO, Adeleke AK (2006) Constituents of the essential oils of Boswellia dalzielii Hutch from Nigeria. J Essent Oil Res 18(2):119\u2013120","journal-title":"J Essent Oil Res"},{"key":"505_CR18","doi-asserted-by":"publisher","first-page":"457","DOI":"10.3109\/08830189809043005","volume":"16","author":"CA Dinarello","year":"1998","unstructured":"Dinarello CA (1998) Interleukin-1, interleukin-1 receptors and interleukin-1 receptor antagonist. Int Rev Immunol 16:457\u2013499","journal-title":"Int Rev Immunol"},{"issue":"1","key":"505_CR19","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1055\/s-2006-959594","volume":"59","author":"M Duwiejua","year":"1993","unstructured":"Duwiejua M, Zeitlin IJ, Waterman PG, Chapman J, Mhango GJ, Provan GJ (1993) Antiinflammatory activity of resins from some of the plant family burseraceae. Planta Med 59(1):12\u201316","journal-title":"Planta Med"},{"issue":"1","key":"505_CR20","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1016\/j.biopha.2003.11.004","volume":"58","author":"J Emerit","year":"2004","unstructured":"Emerit J, Edeas M, Bricaire F (2004) Neurodegenerative diseases and oxidative stress. Biomed Pharmacother 58(1):39\u201346","journal-title":"Biomed Pharmacother"},{"issue":"5","key":"505_CR21","doi-asserted-by":"publisher","first-page":"359","DOI":"10.4103\/0253-7613.27707","volume":"38","author":"EU Ethuk","year":"2006","unstructured":"Ethuk EU, Agale BM, Onyeyili PA, Ottah CU (2006) Toxicological studies of aqueous stem bark extract of Boswellia dalzielii in albino rats. Indian J Pharmacol 38(5):359\u2013360","journal-title":"Indian J Pharmacol"},{"key":"505_CR22","first-page":"474","volume-title":"Trease and Evans\u2019Pharmacognosy","author":"WC Evans","year":"1989","unstructured":"Evans WC (1989) Trease and Evans\u2019Pharmacognosy, 13th edn. ELBS\/Bailliere Tindall, London, pp 474\u2013475","edition":"13"},{"key":"505_CR23","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1056\/NEJM200108093450607","volume":"345","author":"GA Fitzgerald","year":"2001","unstructured":"Fitzgerald GA, Patrono C (2001) The coxibs, selective inhibitors of cyclooxygenase-2. N Engl J Med 345:433\u2013442","journal-title":"N Engl J Med"},{"key":"505_CR24","doi-asserted-by":"publisher","first-page":"367","DOI":"10.4103\/0974-8490.159569","volume":"7","author":"HS Foyet","year":"2015","unstructured":"Foyet HS, Tsala DE, Zogo Essono Bodo JC, Carine AN, Heroyne LT, Oben EK (2015) Anti-inflammatory and antiarthritic activity of a methanol extract from Vitellaria paradoxastem bark. Pharmacognosy Res 7:367\u2013377","journal-title":"Pharmacognosy Res"},{"key":"505_CR25","doi-asserted-by":"publisher","first-page":"240","DOI":"10.1016\/j.ejphar.2007.02.026","volume":"563","author":"C Gabriella","year":"2007","unstructured":"Gabriella C, Maristella A, Elena G, Iwan de Esch JP, Rob L (2007) Antiinflammatory and antinociceptive effects of the selective histamine H4-receptor antagonists JNJ7777120 and VUF6002 in a rat model of carrageenan-induced acute inflammation. Eur J Pharmacol 563:240\u2013244","journal-title":"Eur J Pharmacol"},{"key":"505_CR26","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1016\/0304-3959(88)90026-7","volume":"32","author":"K Hargreaves","year":"1988","unstructured":"Hargreaves K, Dubner R, Brown F, Flores C, Joris J (1988) A new and sensitive method for measuring thermal nociception in cutaneous hyperalgesia. Pain 32:77\u201388","journal-title":"Pain"},{"issue":"4","key":"505_CR27","doi-asserted-by":"publisher","first-page":"282","DOI":"10.1080\/00173130500477902","volume":"44","author":"MM Harley","year":"2005","unstructured":"Harley MM, Song U, Banks HI (2005) Pollen morphology and systematics of Burseraceae. Grana 44(4):282\u2013299","journal-title":"Grana"},{"issue":"1","key":"505_CR28","first-page":"1","volume":"8","author":"HS Hassan","year":"2009","unstructured":"Hassan HS, Musa AM, Usman MA, Abdulaziz M (2009) Preliminary phytochemical and antispasmodic studies of the stem bark of Boswellia dalzielii. Niger J Pharm Sciences 8(1):1\u20136","journal-title":"Niger J Pharm Sciences"},{"key":"505_CR29","doi-asserted-by":"publisher","first-page":"700","DOI":"10.1016\/j.jep.2011.09.042","volume":"138","author":"S Jalalpure","year":"2011","unstructured":"Jalalpure S, Mandavkar Y, Khalure P, Shinde G, Shelar P, Shah A (2011) Antiarthritic activity of various extracts of Mesua ferrea Linn. Seed. J Ethnopharmacol 138:700\u2013704","journal-title":"Seed. J Ethnopharmacol"},{"key":"505_CR30","volume-title":"Plant Systematics: A Phylogenetic Approach","author":"WS Judd","year":"2008","unstructured":"Judd WS, Campbell CS, Kellogg EA, Stevens PF, Donoghue MJ (2008) Plant Systematics: A Phylogenetic Approach, 3rd edn. Sinauer Associates Inc, Sunderland","edition":"3"},{"key":"505_CR31","doi-asserted-by":"publisher","first-page":"15199","DOI":"10.3390\/ijms140815199","volume":"14","author":"L Jung-Chun","year":"2013","unstructured":"Jung-Chun L, Jen-Chieh T, Wen-Huang P, Yung-Jia C, Ping-Jyun S, Minoru T, Yueh-Hsiung K (2013) Anti-inflammatory activity of N-(3-florophenyl)ethylcaffeamide in mice. Int J Mol Sci 14:15199\u201315211","journal-title":"Int J Mol Sci"},{"key":"505_CR32","first-page":"932","volume":"49","author":"G Kaithwas","year":"2011","unstructured":"Kaithwas G, Mukherjee A, Chaurasia AK, Majumdar DK (2011) Antiinflammatory, analgesic and antipyretic activities of Linumu sitatissimum L. (flaxseed\/linseed) fixed oil. Indian J Exp Biol 49:932\u2013938","journal-title":"Indian J Exp Biol"},{"key":"505_CR33","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1016\/j.jep.2003.10.009","volume":"90","author":"G Kaur","year":"2004","unstructured":"Kaur G, Hamid H, Ali A, Alam MS, Athar M (2004) Antiinflammatory evaluation of alcoholic extract of galls of Quercus infectoria. J Ethnopharmacol 90:285\u2013292","journal-title":"J Ethnopharmacol"},{"issue":"1","key":"505_CR34","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1016\/j.jep.2012.04.053","volume":"142","author":"H Kim","year":"2012","unstructured":"Kim H, Lee MR, Lee GS, An WG, Cho SZI (2012) Effect of Sophora flavescens Aiton extract on degranulation of mast cells and contact dermatitis induced by dinitrofluorobenzene in mice. J Ethnopharmacol 142(1):253\u2013258","journal-title":"J Ethnopharmacol"},{"issue":"5","key":"505_CR35","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1007\/s10787-011-0086-4","volume":"19","author":"AB Lende","year":"2011","unstructured":"Lende AB, Kshirsagar AD, Deshpande AD, Muley MM, Patil RR, Bafna PA, Naik SR (2011) Antiinflammatory and analgesic activity of protocatechuic acid in rats and mice. Inflammopharmacology 19(5):255\u2013263","journal-title":"Inflammopharmacology"},{"key":"505_CR36","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1016\/S0014-2999(00)00375-7","volume":"399","author":"A Linardi","year":"2000","unstructured":"Linardi A, Costa SKP, De Silva GR, Antunes E (2000) Involvement of kinins, mast cells and sensory neurons in the plasma exudation and paw edema induced by staphylococcal enterotoxin B in the mouse. Eur J Pharmacol 399:235\u2013242","journal-title":"Eur J Pharmacol"},{"issue":"2","key":"505_CR37","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1016\/j.jep.2006.09.020","volume":"110","author":"MF Mahomoodally","year":"2007","unstructured":"Mahomoodally MF, Gurib-Fakim A, Subratty AH (2007) Effect of exogenous ATP on Momordica charantia Linn. (Cucurbitaceae) induced inhibition of d-glucose, l-tyrosine and fluid transport across rat everted intestinal sacs in vitro. J Ethnopharmacol 110(2):257\u2013263","journal-title":"J Ethnopharmacol"},{"issue":"4","key":"505_CR38","first-page":"305","volume":"6","author":"SA Mard","year":"2015","unstructured":"Mard SA, Mojadami S, Farbood Y, Naseri MKG (2015) The anti-inflammatory and anti-apoptotic effects of gallic acid against mucosal inflammation- and erosions-induced by gastric ischemia-reperfusion in rats. Vet Res Forum 6(4):305\u2013311","journal-title":"Vet Res Forum"},{"key":"505_CR39","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/6374907","author":"M Mbiantcha","year":"2017","unstructured":"Mbiantcha M, Ngouonpe WA, Dawe A, Yousseu NW, Ateufack G (2017a) Antinociceptive activities of the methanolic extract of the stem bark of Boswellia dalzielii Hutch (Burseraceae) in rats are NO\/cGMP\/ATP-sensitive-K + channel activation dependent. Evid Based Complement Alternat Med. https:\/\/doi.org\/10.1155\/2017\/6374907 (Article ID 6374907)","journal-title":"Evid Based Complement Alternat Med"},{"key":"505_CR40","doi-asserted-by":"publisher","DOI":"10.1186\/s12906-017-1623-5","author":"M Mbiantcha","year":"2017","unstructured":"Mbiantcha M, Almas J, Shabana SU, Nida D, Aisha F (2017b) Anti-arthritic property of crude extracts of Piptadeniastrum africanum (Mimosaceae) in complete Freund\u2019s adjuvant-induced arthritis in rats. BMC Complement Altern Med. https:\/\/doi.org\/10.1186\/s12906-017-1623-5","journal-title":"BMC Complement Altern Med"},{"issue":"2","key":"505_CR41","first-page":"130","volume":"5","author":"A Mehta","year":"2012","unstructured":"Mehta A, Sethiya N, Mehta C, Shah G (2012) Anti-arthritis activity of roots of Hemidesmu sindicus R. Br. (Anantmul) in rats. Asian Pac. J Trop Med 5(2):130\u2013135","journal-title":"J Trop Med"},{"issue":"11","key":"505_CR42","doi-asserted-by":"publisher","first-page":"1855","DOI":"10.1016\/j.molimm.2005.10.020","volume":"43","author":"MA Mesaik","year":"2006","unstructured":"Mesaik MA, Ul-Haq Z, Murad S, Ismail Z, Abdullah NR, Gill HK, Yousaf M, Siddiqui RA, Ahmad A, Choudhary MI (2006) Biological and molecular docking studies on coagulin-H: human IL-2 novel natural inhibitor. Mol Immunol 43(11):1855\u20131863","journal-title":"Mol Immunol"},{"key":"505_CR43","first-page":"115","volume":"225","author":"CJ Morris","year":"2003","unstructured":"Morris CJ, Ferreira SH, Vane JR (2003) Carrageenan-induced paw edema in the rat and mouse. Methods Mol Biol 225:115\u2013121","journal-title":"Methods Mol Biol"},{"key":"505_CR44","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1016\/j.cbi.2008.02.007","volume":"173","author":"R Mythilypriya","year":"2008","unstructured":"Mythilypriya R, Shanthi P, Sachdanandam P (2008) Salubrious effect of Kalpa amruthaa, a modified indigenous preparation in adjuvant-induced arthritis in rats\u2013A biochemical approach. Chem Biol Interact 173:148\u2013158","journal-title":"Chem Biol Interact"},{"key":"505_CR45","unstructured":"Nando DD, Amitabh D, Young GC (2013) The anti-oxidative and anti-inflammatory roles of gallic acid on transcriptional regulation. In: Handbook on gallic acid. Nova science publishers, Inc., pp. 135\u2013156"},{"key":"505_CR46","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1007\/s10787-009-0010-3","volume":"17","author":"J Niazi","year":"2009","unstructured":"Niazi J, Singh P, Bansal Y, Goel RK (2009) Anti-inflammatory, analgesic and antipyretic activity of aqueous extract of fresh leaves of Coccinia indica. Inflammopharmacology 17:239\u2013244","journal-title":"Inflammopharmacology"},{"issue":"10","key":"505_CR47","first-page":"100","volume":"9","author":"S Ntiejumokwu","year":"1991","unstructured":"Ntiejumokwu S, Alemika TOE (1991) Antimicrobial and phytochemical investigation of the stem bark of Boswellia dalzielii. W Afr J Pharmacol Drug Res 9(10):100\u2013104","journal-title":"W Afr J Pharmacol Drug Res"},{"issue":"5","key":"505_CR48","doi-asserted-by":"publisher","first-page":"284","DOI":"10.5897\/AJB2004.000-2052","volume":"3","author":"FC Nwinyi","year":"2004","unstructured":"Nwinyi FC, Binda L, Ajoku GA, Aniagu SO, Enwerem NM, Orisadipe A, Kubmarawa D, Gamaniel KS (2004) Evaluation of the aqueous extract of Boswellia dalzielii stem bark for antimicrobial activities and gastrointestinal effects. Afr J Biotechnol 3(5):284\u2013288","journal-title":"Afr J Biotechnol"},{"issue":"3","key":"505_CR49","first-page":"54","volume":"1","author":"OB Odeghe","year":"2012","unstructured":"Odeghe OB, Onoriose DA, Uwakwe AA, Monago CC (2012) Hepatoprotective effect of methanolic leaf extract of Boswellia dalzielii Hutch on carbon tetrachloride induced hepatotoxicity in Wistar rats. Indian J Med Healthc 1(3):54\u201363","journal-title":"Indian J Med Healthc"},{"issue":"4","key":"505_CR50","doi-asserted-by":"publisher","first-page":"269","DOI":"10.3724\/SP.J.1009.2012.00269","volume":"10","author":"P Patel","year":"2012","unstructured":"Patel P, Patel D, Patel N (2012) Experimental investigation of anti-rheumatoid activity of Pleurotus sajorcaju in adjuvant-induced arthritic rats. Chin J Nat Med 10(4):269\u2013274","journal-title":"Chin J Nat Med"},{"issue":"11","key":"505_CR51","first-page":"177","volume":"3","author":"K Patil","year":"2007","unstructured":"Patil K, Suryavanshi J (2007) Effect of Celastrus paniculatus Willd. seed on adjuvant induced arthritis in rats. Pharmacogn Mag 3(11):177\u2013181","journal-title":"Pharmacogn Mag"},{"key":"505_CR52","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1016\/S0378-8741(01)00253-7","volume":"76","author":"C Perez-Gurrero","year":"2001","unstructured":"Perez-Gurrero C, Herrera MD, Ortiz R, Alvarez de Sotomayor M, Fernandez MA (2001) A pharmacological study of Cecropia obtusifolia Bertol aqueous extract. J Ethnopharmacol 76:279\u2013284","journal-title":"J Ethnopharmacol"},{"key":"505_CR53","first-page":"1550","volume":"273","author":"L Philippe","year":"1997","unstructured":"Philippe L, Gegout-Pottie P, Guingamp C (1997) Relations between functional, inflammatory, and degenerative parameters during adjuvant arthritis in rats. Am J Physiol 273:1550\u20131556","journal-title":"Am J Physiol"},{"key":"505_CR54","first-page":"409","volume":"111","author":"LO Randall","year":"1957","unstructured":"Randall LO, Selitto JJ (1957) A method for measurement of analgesic activity on inflamed tissue. Arch Int Pharmacodyn Ther 111:409\u2013419","journal-title":"Arch Int Pharmacodyn Ther"},{"key":"505_CR55","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/195327","author":"C Rita","year":"2014","unstructured":"Rita C, Bruno V, Helena R, Ana NC, Nuno F, Vineet G, Jo\u00e3o EF, Luis FM (2014) Potent Anti- Inflammatory and Antiproliferative Effects of Gambogic Acid in a Rat Model of Antigen-Induced Arthritis. Mediat Inflamm. https:\/\/doi.org\/10.1155\/2014\/195327","journal-title":"Mediat Inflamm"},{"issue":"3","key":"505_CR56","doi-asserted-by":"publisher","first-page":"149","DOI":"10.3923\/ijbc.2007.149.155","volume":"1","author":"EP Sabina","year":"2007","unstructured":"Sabina EP, Rasool M (2007) Therapeutic efficacy of Indian ayurvedic herbal formulation triphala on lipid peroxidation, antioxidant status and inflammatory mediator TNF-\u03b1 in adjuvant-induced arthritic mice. Int J Biol Chem 1(3):149\u2013155","journal-title":"Int J Biol Chem"},{"issue":"2\u20133","key":"505_CR57","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1016\/j.jep.2004.03.007","volume":"92","author":"K Saha","year":"2004","unstructured":"Saha K, Lajis NH, Israf DA, Hamzah AS, Khozirah S, Khamis S, Syahida A (2004) Evaluation of antioxidant and nitric oxide inhibitory activities of selected Malaysian medicinal plants. J Ethnopharmacol 92(2\u20133):263\u2013267","journal-title":"J Ethnopharmacol"},{"key":"505_CR58","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/952943","author":"K Sahil","year":"2014","unstructured":"Sahil K, Souravh B (2014) A review on protocatechuic acid and its pharmacological potential. ISRN Pharmacol. https:\/\/doi.org\/10.1155\/2014\/952943","journal-title":"ISRN Pharmacol"},{"issue":"2","key":"505_CR59","first-page":"362","volume":"58","author":"HM Sheng","year":"1998","unstructured":"Sheng HM, Shao JY, Morrow JD, Beauchamp RD, Dubois RN (1998) Modulation of apoptosis and bcl-2 expression by prostaglandin E-2 in human colon cancer cells. Cancer Res 58(2):362\u2013366","journal-title":"Cancer Res"},{"issue":"12","key":"505_CR60","doi-asserted-by":"publisher","first-page":"2252","DOI":"10.1373\/clinchem.2005.056093","volume":"51","author":"U Singh","year":"2005","unstructured":"Singh U, James T, Senthil KV, Sridevi D, Ishwarlal J (2005) Development of an in vitro screening assay to test the anti-inflammatory properties of dietary supplements and pharmacologic agents. Clin Chem 51(12):2252\u20132256","journal-title":"Clin Chem"},{"issue":"2","key":"505_CR61","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1186\/rr40","volume":"2","author":"JW Steinke","year":"2001","unstructured":"Steinke JW, Borish L (2001) Th2 cytokines and asthma. Interleukin-4: its role in the pathogenesis of asthma, and targeting it for asthma treatment with interleukin-4 receptor antagonists. Respir Res 2(2):66\u201370","journal-title":"Respir Res"},{"key":"505_CR62","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1093\/ecam\/neh024","volume":"1","author":"N Taniguchi","year":"2004","unstructured":"Taniguchi N, Kanai S, Kawamoto M, Endo H, Higashino H (2004) Study on application of static magnetic field for adjuvant arthritis rats. J Evid Based Complement Altern Med 1:187\u2013191","journal-title":"J Evid Based Complement Altern Med"},{"key":"505_CR63","first-page":"96","volume":"3","author":"S Tripathy","year":"2010","unstructured":"Tripathy S, Sahoo SP, Pradham D, Sahoo S, Satapathy DK (2010) Evaluation of anti-arthritic potential of Hybanthus enneaspermus. Afr J Pharm Pharmacol 3:96\u2013100","journal-title":"Afr J Pharm Pharmacol"},{"issue":"4","key":"505_CR64","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1007\/BF02859654","volume":"40","author":"A Tucker","year":"1986","unstructured":"Tucker A (1986) Frankincense and myrrh. Econ Bot 40(4):425\u2013433","journal-title":"Econ Bot"},{"issue":"5","key":"505_CR65","first-page":"76","volume":"3","author":"D Uzama","year":"2015","unstructured":"Uzama D, Gbubele JD, Bwai MD, Kabir MG (2015) Phytochemical, nutritional and antimicrobial screening of hexane, ethyl acetate and ethanolic extracts of Boswellia Dalzielii leaves and bark. Am J Biosci Bioeng 3(5):76\u201379","journal-title":"Am J Biosci Bioeng"},{"key":"505_CR73","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1016\/S0304-4165(01)00163-5","volume":"1527","author":"M Valko","year":"2001","unstructured":"Valko M, Morris H, Mazur M, Rapta P, Bilton RF (2001) Oxygen free radical generating mechanisms in the colon: Do the semiquinones of Vitamin K play a role in the aetiology of colon cancer? Biochim Biophys Acta 1527:161\u2013166","journal-title":"Biochim Biophys Acta"},{"issue":"1","key":"505_CR66","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.cbi.2005.12.009","volume":"160","author":"M Valko","year":"2006","unstructured":"Valko M, Rhodes CJ, Moncol J, Izakovic M, Mazur M (2006) Free radicals, metals and antioxidants in oxidative stress induced cancer. Chem Biol Interact 160(1):1\u201340","journal-title":"Chem Biol Interact"},{"key":"505_CR67","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/S0022-3565(25)28209-X","volume":"166","author":"R Vinegar","year":"1969","unstructured":"Vinegar R, Schreiber W, Hugo R (1969) Biphasic development of carrageenan edema in rats. J Pharmacol Exp Ther 166:96\u2013103","journal-title":"J Pharmacol Exp Ther"},{"issue":"1","key":"505_CR68","first-page":"118","volume":"46","author":"R Vinegar","year":"1987","unstructured":"Vinegar R, Truax JF, Selph JL, Johnston PR, Venable AL, McKenzie KK (1987) Pathway to carrageenan induced inflammation in the hind limb of the rat. Fed Proc 46(1):118\u2013126","journal-title":"Fed Proc"},{"issue":"1","key":"505_CR69","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1016\/j.ympev.2004.12.021","volume":"35","author":"A Weeks","year":"2005","unstructured":"Weeks A, Daly DC, Simpson BB (2005) The phylogenetic history and biogeography of the frankincense and myrrh family (Burseraceae) based on nuclear and chloroplast sequence data. Mol Phylogenet Evol 35(1):85\u2013101","journal-title":"Mol Phylogenet Evol"},{"key":"505_CR70","doi-asserted-by":"publisher","first-page":"544","DOI":"10.3181\/00379727-111-27849","volume":"3","author":"CA Winter","year":"1962","unstructured":"Winter CA, Risley EA, Nuss GW (1962) Carrageenan-induced edema in hind paw of the rats as an assay for antiinflammatory drugs. Proc Soc Exp Biol Med 3:544\u2013547","journal-title":"Proc Soc Exp Biol Med"},{"issue":"12","key":"505_CR71","doi-asserted-by":"publisher","first-page":"1180","DOI":"10.3736\/jcim20101211","volume":"8","author":"J Zaringhalam","year":"2010","unstructured":"Zaringhalam J, Akbari A, Tekieh E, Manaheji H, Rezazadeh S (2010) Achillea santolina reduces serum interleukin-6 level and hyperalgesia during complete Freund\u2019s adjuvant induced inflammation in male Wistar rats. Zhong Xi Yi Jie He Xue Bao 8(12):1180\u20131189","journal-title":"Zhong Xi Yi Jie He Xue Bao"},{"issue":"2","key":"505_CR72","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1016\/0304-3959(83)90201-4","volume":"16","author":"M Zimmerman","year":"1983","unstructured":"Zimmerman M (1983) Ethical guidelines for investigations of experimental pain in conscious animals. Pain 16(2):109\u2013110","journal-title":"Pain"}],"container-title":["Inflammopharmacology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10787-018-0505-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10787-018-0505-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10787-018-0505-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,5]],"date-time":"2025-07-05T03:07:38Z","timestamp":1751684858000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10787-018-0505-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,6,13]]},"references-count":73,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2018,12]]}},"alternative-id":["505"],"URL":"https:\/\/doi.org\/10.1007\/s10787-018-0505-x","relation":{},"ISSN":["0925-4692","1568-5608"],"issn-type":[{"value":"0925-4692","type":"print"},{"value":"1568-5608","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,6,13]]},"assertion":[{"value":"29 March 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 June 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 June 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"For this study, the animal facility of H.E.J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Pakistan were used. Experiments were executed under the ethical guidelines of the International Association for the Study of Pain in Conscious Animals and guidelines set by for the scientific advisory committee, animal care, use and standards, ICCBS were followed (Protocol No. 1209004). For the donation of human blood samples, all processes of collecting blood were accepted by independent ethics committee, ICCBS, University of Karachi, no: ICCBS\/IEC-008-BC-2015\/Protocol\/1.0. The blood donors provided informed approval for the use of their blood for the purposes of this study.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interests"}}]}}