{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T10:36:01Z","timestamp":1780396561542,"version":"3.54.1"},"reference-count":45,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2019,9,3]],"date-time":"2019-09-03T00:00:00Z","timestamp":1567468800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2019,9,3]],"date-time":"2019-09-03T00:00:00Z","timestamp":1567468800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Inflammopharmacol"],"published-print":{"date-parts":[[2020,2]]},"DOI":"10.1007\/s10787-019-00637-x","type":"journal-article","created":{"date-parts":[[2019,9,3]],"date-time":"2019-09-03T19:07:43Z","timestamp":1567537663000},"page":"321-331","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["In vivo antiulcer activity, phytochemical exploration, and molecular modelling of the polyphenolic-rich fraction of Crepis sancta extract"],"prefix":"10.1007","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2753-0031","authenticated-orcid":false,"given":"Sherif S.","family":"Ebada","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nariman A.","family":"Al-Jawabri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fadia S.","family":"Youssef","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amgad","family":"Albohy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sa\u2019ed M.","family":"Aldalaien","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmad M.","family":"Disi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Proksch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,9,3]]},"reference":[{"key":"637_CR1","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1038\/ncomms1154","volume":"2","author":"K Abe","year":"2011","unstructured":"Abe K, Tani K, Fujiyoshi Y (2011) Conformational rearrangement of gastric H+, K+-ATPase induced by an acid suppressant. Nat Commun 2:155","journal-title":"Nat Commun"},{"key":"637_CR2","doi-asserted-by":"publisher","first-page":"214","DOI":"10.1038\/s41586-018-0003-8","volume":"556","author":"K Abe","year":"2018","unstructured":"Abe K, Irie K, Nakanishi H, Suzuki H, Fujiyoshi Y (2018) Crystal structures of the gastric proton pump. Nature 556:214\u2013218","journal-title":"Nature"},{"key":"637_CR3","doi-asserted-by":"publisher","first-page":"1684","DOI":"10.1002\/ptr.2539","volume":"22","author":"H-A Ali","year":"2008","unstructured":"Ali H-A, Chowdhury AKA, Rahman AKM, Borkowski T, Nahar L, Sarker SD (2008) Pachypodol, a flavonol from the leaves of Calycopteris floribunda, inhibits the growth of Caco 2 colon cancer cell line in vitro. Phytother Res 22:1684\u20131687","journal-title":"Phytother Res"},{"issue":"1","key":"637_CR4","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1016\/j.phymed.2014.10.002","volume":"22","author":"E Al-Sayed","year":"2015","unstructured":"Al-Sayed E, El-Naga RN (2015) Protective role of ellagitannins from Eucalyptus citriodora against ethanol-induced gastric ulcer in rats: impact on oxidative stress, inflammation and calcitonin-gene related peptide. Phytomedicine 22(1):5\u201315","journal-title":"Phytomedicine"},{"key":"637_CR5","doi-asserted-by":"publisher","first-page":"e25878","DOI":"10.1371\/journal.pone.0025878","volume":"6","author":"JM Alvarez-Suarez","year":"2011","unstructured":"Alvarez-Suarez JM, Dekanski D, Risti\u0107 S, Radonji\u0107 NV, Petronijevi\u0107 ND, Giampieri F, Astolfi P, Gonz\u00e1lez-Param\u00e1s AM, Santos-Buelga C, Tulipani S, Quiles JL, Mezzetti B, Battino M (2011) Strawberry polyphenols attenuate ethanol-induced gastric lesions in rats by activation of antioxidant enzymes and attenuation of MDA increase. PLoS ONE 6:e25878","journal-title":"PLoS ONE"},{"key":"637_CR6","first-page":"1163","volume":"14","author":"G Amin","year":"2015","unstructured":"Amin G, Najarnezhada V, Anassoria E, Mostafavib M, Keshipourc H (2015) Antiulcer properties of Glycyrrhiza glabra L. extract on experimental models of gastric ulcer in mice. Iran J Pharm Res 14:1163\u20131170","journal-title":"Iran J Pharm Res"},{"key":"637_CR7","first-page":"119","volume":"34","author":"MT Azizuddin","year":"2010","unstructured":"Azizuddin MT, Choudhary MI (2010) Radical scavanging potential of compounds isolated from Vitex agnus-castus. Tur. J. Chem. 34:119\u2013126","journal-title":"Tur. J. Chem."},{"key":"637_CR8","volume-title":"Theory and practice of histological techniques","author":"JD Banchroft","year":"1996","unstructured":"Banchroft JD, Stevens A, Turner DR (1996) Theory and practice of histological techniques, 4th edn. Churchil Livingstone, New York\/London\/San Francisco\/Tokyo","edition":"4"},{"key":"637_CR9","doi-asserted-by":"publisher","first-page":"424","DOI":"10.1080\/00015458.2008.11680254","volume":"108","author":"G Bas","year":"2008","unstructured":"Bas G, Erylimaz R, Okan I, Sahin M (2008) Risk factors of morbidity and mortality in patients with perforated peptic ulcer. Acta Chir Belg 108:424\u2013427","journal-title":"Acta Chir Belg"},{"key":"637_CR10","doi-asserted-by":"publisher","first-page":"22438","DOI":"10.1074\/jbc.272.36.22438","volume":"272","author":"M Besancon","year":"1997","unstructured":"Besancon M, Simon A, Sachs G, Shin JM (1997) Sites of reaction of the gastric H+, K+-ATPase with extracytoplasmic thiol reagents. J Biol Chem 272:22438\u201322446","journal-title":"J Biol Chem"},{"key":"637_CR11","doi-asserted-by":"publisher","first-page":"1","DOI":"10.4240\/wjgs.v9.i1.1","volume":"9","author":"KT Chung","year":"2017","unstructured":"Chung KT, Shelat VG (2017) Perforated peptic ulcer - an update. World J Gastrointest Surg 9:1\u201312","journal-title":"World J Gastrointest Surg"},{"key":"637_CR12","doi-asserted-by":"publisher","first-page":"3203","DOI":"10.3390\/ijms13033203","volume":"13","author":"NZT de Jesus","year":"2012","unstructured":"de Jesus NZT, Falcao HDS, Gomes IF, Leite TJDA, Lima GRDM, Barbosa-Filho JM, Tavares JF, Silva MSD, Athayde-Filho PFD, Batista LM (2012) Tannins, peptic ulcers and related mechanisms. Int J Mol Sci 13:3203\u20133228","journal-title":"Int J Mol Sci"},{"key":"637_CR13","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1016\/S0031-9422(01)00066-8","volume":"57","author":"G Flamini","year":"2001","unstructured":"Flamini G, Antognoli E, Morelli I (2001) Two flavonoids and other compounds from the aerial parts of Centaurea bracteata from Italy. Phytochemistry 57:559\u2013564","journal-title":"Phytochemistry"},{"key":"637_CR14","doi-asserted-by":"publisher","first-page":"1739","DOI":"10.1590\/S0100-40422010000800022","volume":"33","author":"FR Garcez","year":"2010","unstructured":"Garcez FR, Garcez WS, Hamerski L, de Miranda AC (2010) Eudesmane and rearranged eudesmane sesquiterpenes from Nectandra cissiflora. Qu\u00edm Nov 33:1739\u20131742","journal-title":"Qu\u00edm Nov"},{"key":"637_CR15","unstructured":"Grossman MI (1963) Physiology for physician. Am Physiol Soc 1\u20135"},{"key":"637_CR16","doi-asserted-by":"publisher","first-page":"659","DOI":"10.1016\/j.jep.2013.01.036","volume":"146","author":"PM Guarrera","year":"2013","unstructured":"Guarrera PM, Savo V (2013) Perceived health properties of wild and cultivated food plants in local and popular traditions of Italy: A review. J Ethnopharmacol 146:659\u2013680","journal-title":"J Ethnopharmacol"},{"key":"637_CR17","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1016\/j.chroma.2007.02.105","volume":"1151","author":"X Han","year":"2007","unstructured":"Han X, Ma X, Zhang T, Zhang Y, Liu Q, Ito Y (2007) Isolation of high-purity casticin from Artemisia annua L. by high-speed counter-current chromatography. J Chrom A 1151:180\u2013182","journal-title":"J Chrom A"},{"key":"637_CR18","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1016\/j.phytochem.2014.03.027","volume":"103","author":"M-EF Hegazy","year":"2014","unstructured":"Hegazy M-EF, Matsuda H, Nakamura S, Hussein TA, Yoshikawa M, Par\u00e9 PW (2014) Chemical constituents and their antibacterial and antifungal activity from the Egyptian herbal medicine Chiliadenus montanus. Phytochemistry 103:154\u2013161","journal-title":"Phytochemistry"},{"key":"637_CR19","doi-asserted-by":"publisher","first-page":"1469","DOI":"10.1021\/jf020808y","volume":"51","author":"S Khennouf","year":"2003","unstructured":"Khennouf S, Benabdallah H, Gharzouli K, Amira S, Ito H, Kim T-H, Yoshida T, Gharzouli A (2003) Effect of tannins from Quercus suber and Quercus coccifera leaves on ethanol-induced gastric lesions in mice. J Agric Food Chem 51:1469\u20131473","journal-title":"J Agric Food Chem"},{"key":"637_CR20","first-page":"1675","volume":"7","author":"O Kilic","year":"2013","unstructured":"Kilic O, Bagci E (2013) An ethnobotanical survey of some medicinal plants in Keban (Elaz\u0131\u011f-Turkey). J Med Plants Res 7:1675\u20131684","journal-title":"J Med Plants Res"},{"key":"637_CR21","unstructured":"Mabberley DJ (2008) Crepis L. Mabberley\u2019s Plant-book. Cambridge University Press, Cambridge, p 227"},{"key":"637_CR22","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1016\/0305-1978(94)90104-X","volume":"22","author":"S Manez","year":"1994","unstructured":"Manez S, Recio MC, Giner RM, Sanz MJ, Terencio MC, Peris JB, Stubing G, Rios J-L (1994) A chemotaxonomic review of the subtribe Crepidinae based on its phenolic constituents. Biochem System Ecol 22:297\u2013306","journal-title":"Biochem System Ecol"},{"key":"637_CR23","doi-asserted-by":"publisher","first-page":"1516","DOI":"10.1002\/ptr.2492","volume":"23","author":"MA Mesaik","year":"2009","unstructured":"Mesaik MA, Murad S, Khan KM, Tareen RB, Ahmed A, Choudhary MI (2009) Isolation and immunomodulatory properties of a flavonoid, casticin from Vitex agnus-castus. Phytother. Res. 23:1516\u20131520","journal-title":"Phytother. Res."},{"key":"637_CR24","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1002\/mrc.4358","volume":"54","author":"K Michalska","year":"2016","unstructured":"Michalska K, Szneler E, Kisiel W (2016) Structure elucidation of an unusual new sequiterpene lactone glucoside ester from Crepis pannonica. Magn Reson Chem 54:175\u2013177","journal-title":"Magn Reson Chem"},{"key":"637_CR25","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1080\/14786410500182300","volume":"20","author":"JC Ndom","year":"2006","unstructured":"Ndom JC, Mbafor JT, Wansi JD, Kamdem AW, Mevaa LM, Vardamides JC, Toukam F, Pegyemb D, Ngando TM, Laatsch H, Fomum ZT (2006) Sesquiterpene lactones from Crepiscameroonica (Asteraceae). Nat. Prod. Res. 20:435\u2013442","journal-title":"Nat. Prod. Res."},{"key":"637_CR26","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1186\/1758-2946-3-33","volume":"3","author":"NM O'Boyle","year":"2011","unstructured":"O'Boyle NM, Banck M, James CA, Morley C, Vandermeersch T, Hutchison GR (2011) Open Babel: an open chemical toolbox. J Cheminform 3:33","journal-title":"J Cheminform"},{"key":"637_CR27","unstructured":"OECD (2001) Guideline for testing of chemicals. Guidance no. 423. Acute Oral Toxicity: Acute Toxic Class Method, Paris"},{"key":"637_CR28","doi-asserted-by":"publisher","first-page":"1605","DOI":"10.1002\/jcc.20084","volume":"25","author":"EF Pettersen","year":"2004","unstructured":"Pettersen EF, Goddard TD, Huang CC, Couch GS, Greenblatt DM, Meng EC, Ferrin TE (2004) UCSF Chimera-a visualization system for exploratory research and analysis. J Comput Chem 25:1605\u20131612","journal-title":"J Comput Chem"},{"key":"637_CR29","unstructured":"Reitman S (1970) Gastric secretion. In: Frankel S, Reitman S, Sonnenwirth AC (Eds) Gradwohl\u2019s clinical laboratory methods and diagnosis, London, pp 1949\u20131958."},{"key":"637_CR30","first-page":"58","volume":"16","author":"SE Sajjadi","year":"2017","unstructured":"Sajjadi SE, Ghanadian SM, Rabbani M, Tahmasbi F (2017) Isolation and identification of secondary metabolites from the aerial parts of Stachys lavandulifolia Vahl. Iran J Pharm Res 16:58\u201363","journal-title":"Iran J Pharm Res"},{"key":"637_CR31","doi-asserted-by":"publisher","first-page":"3245","DOI":"10.3748\/wjg.v13.i23.3245","volume":"13","author":"YK Salih","year":"2007","unstructured":"Salih YK, Abasiyanik MF, Bayyrut N, Sander E (2007) H. pylori infection and oterh risk factors associated with peptic ulcers in Turkish patients: a retrospective study. World J Gastroenterol 13:3245\u20133248","journal-title":"World J Gastroenterol"},{"key":"637_CR32","doi-asserted-by":"publisher","first-page":"e71762","DOI":"10.1371\/journal.pone.0071762","volume":"8","author":"E Sangiovanni","year":"2013","unstructured":"Sangiovanni E, Vrhovsek U, Rossoni G, Colombo E, Brunelli C, Brembati L, Trivulzio S, Gasperotti M, Mattivi F, Bosisio E, Dell\u2019Agli M (2013) Ellagitannins from Rubus berries for the control of gastric inflammation: in vitro and in vivo studies. PLoS ONE 8:e71762","journal-title":"PLoS ONE"},{"issue":"69","key":"637_CR33","first-page":"1","volume":"10","author":"S Sansanelli","year":"2014","unstructured":"Sansanelli S, Tassoni A (2014) Wild food plants traditionally consumed in the area of Bologna (Emilia Romagna region, Italy). J Ethnobiol Ethnomed 10(69):1\u201311","journal-title":"J Ethnobiol Ethnomed"},{"key":"637_CR34","doi-asserted-by":"publisher","first-page":"1301","DOI":"10.1016\/S0031-9422(00)95110-0","volume":"32","author":"S Sepulveda-Boza","year":"1993","unstructured":"Sepulveda-Boza S, Delhvi S, Cassels BK (1993) Flavonoids from the twigs of Eucryphia glutinosa. Phytochemistry 32:1301\u20131303","journal-title":"Phytochemistry"},{"key":"637_CR35","doi-asserted-by":"publisher","first-page":"300","DOI":"10.4166\/kjg.2016.67.6.300","volume":"67","author":"YK Shim","year":"2016","unstructured":"Shim YK, Kim N (2016) Nonsteroidal anti-inflammatory drug and aspirin-induced peptic ulcer disease. Korean J Gastroenterol 67:300\u2013312","journal-title":"Korean J Gastroenterol"},{"key":"637_CR36","doi-asserted-by":"publisher","first-page":"834","DOI":"10.1016\/j.phymed.2013.03.002","volume":"20","author":"HM Sidahmed","year":"2013","unstructured":"Sidahmed HM, Hashim NM, Amir J, Abdulla MA, Hadi AH, Abdelwahab SI, Taha MM, Hassandarvish P, Teh X, Loke MF, Vadivelu J, Rahmani M, Mohan S (2013) Pyranocycloartobiloxanthone A, a novel gastroprotective compound from Artocarpus obtusus Jarret, against ethanol-induced acute gastric ulcer in vivo. Phytomedicine 20:834\u2013843","journal-title":"Phytomedicine"},{"key":"637_CR37","doi-asserted-by":"publisher","first-page":"1140","DOI":"10.1055\/s-2002-36347","volume":"68","author":"FR Stermitz","year":"2002","unstructured":"Stermitz FR, Scriven LN, Tegos G, Lewis K (2002) Two flavonols from Artemisia annua which potentiate the activtiy of berberine and norfloxacin against a resistant strain of Staphylococcus aureus. Planta Med 68:1140\u20131141","journal-title":"Planta Med"},{"key":"637_CR38","doi-asserted-by":"publisher","first-page":"938","DOI":"10.1111\/j.1365-2036.2009.03960.x","volume":"29","author":"JJY Sung","year":"2009","unstructured":"Sung JJY, Kuipers EJ, El-Serag HB (2009) Systematic review: the global incidence and prevalence of peptic ulcer disease. Alim Pharmacol Therap 29:938\u2013946","journal-title":"Alim Pharmacol Therap"},{"key":"637_CR39","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1002\/jcc.21334","volume":"31","author":"O Trott","year":"2010","unstructured":"Trott O, Olson AJ (2010) AutoDock Vina: improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading. J Comput Chem 31:455\u2013461","journal-title":"J Comput Chem"},{"key":"637_CR40","doi-asserted-by":"publisher","first-page":"1217","DOI":"10.1016\/S0016-5085(99)70025-9","volume":"116","author":"SJ Van Zanten","year":"1999","unstructured":"Van Zanten SJ, Dixon MF, Lee A (1999) The gastric transitional zones: neglected links between gastroduodenal pathology and helicobacter ecology. Gastroenterology 116:1217\u20131229","journal-title":"Gastroenterology"},{"key":"637_CR41","doi-asserted-by":"crossref","first-page":"2077","DOI":"10.1016\/S0021-9258(18)61620-5","volume":"262","author":"B Wallmark","year":"1987","unstructured":"Wallmark B, Briving C, Fryklund J, Munson K, Jackson R, Mendlein J, Rabon E, Sachs G (1987) Inhibition of gastric H+, K+-ATPase and acid secretion by SCH 28080, a substituted pyridyl(1,2a)imidazole. J Biol Chem 262:2077\u20132084","journal-title":"J Biol Chem"},{"key":"637_CR42","unstructured":"Winzler RJ (2006) Determination of serum glycoproteins, method of biochemical analysis. Wiley, pp 279\u2013311"},{"key":"637_CR43","doi-asserted-by":"publisher","first-page":"7893","DOI":"10.1021\/acs.jafc.7b01543","volume":"65","author":"J-H Woo","year":"2017","unstructured":"Woo J-H, Ahn J-H, Jang D-S, Lee K-T, Choi J-H (2017) Effect of kumatakenin isolated from cloves on the apoptosis of cancer cells and the alternative activation of tumor-associated macrophages. J Agric Food Chem 65:7893\u20137899","journal-title":"J Agric Food Chem"},{"key":"637_CR44","doi-asserted-by":"publisher","first-page":"910","DOI":"10.1007\/s10600-014-1114-6","volume":"50","author":"X-Y Xie","year":"2014","unstructured":"Xie X-Y, Wang R, Shi Y-P (2014) Flavonoids from the flowers of Matricaria chamomilla. Chem Nat Comp 50:910\u2013911","journal-title":"Chem Nat Comp"},{"key":"637_CR45","first-page":"1005","volume":"76","author":"Y Yuan","year":"2006","unstructured":"Yuan Y, Padol IT, Hunt HR (2006) Peptic ulcer disease. Am Fam Physician 76:1005\u20131012","journal-title":"Am Fam Physician"}],"container-title":["Inflammopharmacology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10787-019-00637-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10787-019-00637-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10787-019-00637-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,22]],"date-time":"2024-07-22T22:35:53Z","timestamp":1721687753000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10787-019-00637-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,9,3]]},"references-count":45,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,2]]}},"alternative-id":["637"],"URL":"https:\/\/doi.org\/10.1007\/s10787-019-00637-x","relation":{},"ISSN":["0925-4692","1568-5608"],"issn-type":[{"value":"0925-4692","type":"print"},{"value":"1568-5608","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,9,3]]},"assertion":[{"value":"17 June 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 August 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 September 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that there is no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}