{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T08:40:28Z","timestamp":1778661628943,"version":"3.51.4"},"reference-count":79,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2019,11,25]],"date-time":"2019-11-25T00:00:00Z","timestamp":1574640000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2019,11,25]],"date-time":"2019-11-25T00:00:00Z","timestamp":1574640000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100004901","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de Minas Gerais","doi-asserted-by":"publisher","award":["APQ-03120-16"],"award-info":[{"award-number":["APQ-03120-16"]}],"id":[{"id":"10.13039\/501100004901","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004901","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de Minas Gerais","doi-asserted-by":"publisher","award":["APQ-03027-18"],"award-info":[{"award-number":["APQ-03027-18"]}],"id":[{"id":"10.13039\/501100004901","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["303307\/2018-8"],"award-info":[{"award-number":["303307\/2018-8"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","award":["Finance Code 001"],"award-info":[{"award-number":["Finance Code 001"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007375","name":"Pr\u00f3-Reitoria de Pesquisa, Universidade Federal de Minas Gerais","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007375","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Inflammopharmacol"],"published-print":{"date-parts":[[2020,4]]},"DOI":"10.1007\/s10787-019-00670-w","type":"journal-article","created":{"date-parts":[[2019,11,25]],"date-time":"2019-11-25T13:02:38Z","timestamp":1574686958000},"page":"551-561","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Clindamycin inhibits nociceptive response by reducing tumor necrosis factor-\u03b1 and CXCL-1 production and activating opioidergic mechanisms"],"prefix":"10.1007","volume":"28","author":[{"given":"Felipe F.","family":"Rodrigues","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcela I.","family":"Morais","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ivo S. F.","family":"Melo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paulo S. A.","family":"Augusto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcela M. G. B.","family":"Dutra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah O. A. M.","family":"Costa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F\u00e1bio C.","family":"Costa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Franciele A.","family":"Goulart","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alysson V.","family":"Braga","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M\u00e1rcio M.","family":"Coelho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1284-1195","authenticated-orcid":false,"given":"Renes R.","family":"Machado","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2019,11,25]]},"reference":[{"key":"670_CR1","doi-asserted-by":"publisher","first-page":"614","DOI":"10.1007\/BF03011880","volume":"42","author":"O Al Ahdal","year":"1995","unstructured":"Al Ahdal O, Bevan DR (1995) Clindamycin-induced neuromuscular blockade. Can J Anesth 42:614\u2013617. https:\/\/doi.org\/10.1007\/BF03011880","journal-title":"Can J Anesth"},{"key":"670_CR2","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1016\/s0014-2999(02)01412-7","volume":"444","author":"D Alves","year":"2002","unstructured":"Alves D, Duarte I (2002) Involvement of ATP-sensitive K(+) channels in the peripheral antinociceptive effect induced by dipyrone. Eur J Pharmacol 444:47\u201352. https:\/\/doi.org\/10.1016\/s0014-2999(02)01412-7","journal-title":"Eur J Pharmacol"},{"key":"670_CR3","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1016\/0079-6107(89)90013-8","volume":"54","author":"FM Ashcroft","year":"1989","unstructured":"Ashcroft FM, Rorsman P (1989) Electrophysiology of the pancreatic beta-cell. Prog Biophys Mol Biol 54:87\u2013143. https:\/\/doi.org\/10.1016\/0079-6107(89)90013-8","journal-title":"Prog Biophys Mol Biol"},{"key":"670_CR4","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1007\/s40263-013-0128-0","volume":"28","author":"LF Bastos","year":"2014","unstructured":"Bastos LF, Coelho MM (2014) Drug repositioning: playing dirty to kill pain. CNS Drugs 28:45\u201361. https:\/\/doi.org\/10.1007\/s40263-013-0128-0","journal-title":"CNS Drugs"},{"key":"670_CR5","doi-asserted-by":"publisher","first-page":"714","DOI":"10.1038\/bjp.2008.303","volume":"155","author":"LF Bastos","year":"2008","unstructured":"Bastos LF, Angusti A, Vila\u00e7a MC, Merlo LA, Nascimento EB Jr, Rocha LT, Godin AM, Solano AG, Jarussophon S, Nunan EA, Konishi Y, Coelho MM (2008) A novel non-antibacterial, non-chelating hydroxypyrazoline derivative of minocycline inhibits nociception and oedema in mice. Br J Pharmacol 155:714\u2013721. https:\/\/doi.org\/10.1038\/bjp.2008.303","journal-title":"Br J Pharmacol"},{"key":"670_CR6","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1007\/s00210-012-0727-1","volume":"385","author":"LF Bastos","year":"2012","unstructured":"Bastos LF, de Oliveira AC, Watkins LR, Moraes MF, Coelho MM (2012) Tetracyclines and pain. Naunyn Schmiedebergs Arch Pharmacol 385:225\u2013241. https:\/\/doi.org\/10.1007\/s00210-012-0727-1","journal-title":"Naunyn Schmiedebergs Arch Pharmacol"},{"key":"670_CR7","doi-asserted-by":"publisher","first-page":"849","DOI":"10.1189\/jlb.70.6.849","volume":"70","author":"A Billiau","year":"2001","unstructured":"Billiau A, Matthys P (2001) Modes of action of Freund\u2019s adjuvants in experimental models of autoimmune diseases. J Leukoc Biol 70:849\u2013860. https:\/\/doi.org\/10.1189\/jlb.70.6.849","journal-title":"J Leukoc Biol"},{"key":"670_CR8","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1016\/j.cytogfr.2011.11.003","volume":"22","author":"A Billiau","year":"2011","unstructured":"Billiau A, Matthys P (2011) Collagen-induced arthritis and related animal models: how much of their pathogenesis is autoimmune, how much is auto-inflammatory? Cytokine Growth Factor Rev 22:339\u2013344. https:\/\/doi.org\/10.1016\/j.cytogfr.2011.11.003","journal-title":"Cytokine Growth Factor Rev"},{"key":"670_CR9","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1016\/j.pain.2004.08.029","volume":"112","author":"A Brack","year":"2004","unstructured":"Brack A, Rittner HL, Machelska H, Leder K, Mousa SA, Sch\u00e4fer M, Stein C (2004) Control of inflammatory pain by chemokine-mediated recruitment of opioid-containing polymorphonuclear cells. Pain 112:229\u2013238. https:\/\/doi.org\/10.1016\/j.pain.2004.08.029","journal-title":"Pain"},{"key":"670_CR10","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/j.ejphar.2017.10.026","volume":"818","author":"AMS Brito","year":"2018","unstructured":"Brito AMS, Godin AM, Augusto PSA, Menezes RR, Melo ISF, Dutra MGMB, Costa SOAM, Goulart FA, Rodrigues FF, Morais IM, Machado RR, Coelho MM (2018) Antiallodynic activity of leflunomide is partially inhibited by naltrexone and glibenclamide and associated with reduced production of TNF-\u03b1 and CXCL-1. Eur J Pharmacol 818:17\u201325. https:\/\/doi.org\/10.1016\/j.ejphar.2017.10.026","journal-title":"Eur J Pharmacol"},{"key":"670_CR11","doi-asserted-by":"publisher","first-page":"328","DOI":"10.1016\/j.expneurol.2014.05.014","volume":"261","author":"DL Cao","year":"2014","unstructured":"Cao DL, Zhang ZJ, Xie RG, Jiang BC, Ji RR, Gao YJ (2014) Chemokine CXCL1 enhances inflammatory pain and increases NMDA receptor activity and COX-2 expression in spinal cord neurons via activation of CXCR2. Exp Neurol 261:328\u2013336. https:\/\/doi.org\/10.1016\/j.expneurol.2014.05.014","journal-title":"Exp Neurol"},{"key":"670_CR12","doi-asserted-by":"publisher","first-page":"1166","DOI":"10.1038\/sj.bjp.0704371","volume":"134","author":"M Carollo","year":"2001","unstructured":"Carollo M, Hogaboam CM, Kunkel SL, Delaney S, Christie MI, Perretti M (2001) Analysis of the temporal expression of chemokines and chemokine receptors during experimental granulomatous inflammation: role and expression of MIP-1alpha and MCP-1. Br J Pharmacol 134:1166\u20131179. https:\/\/doi.org\/10.1038\/sj.bjp.0704371","journal-title":"Br J Pharmacol"},{"key":"670_CR13","doi-asserted-by":"publisher","first-page":"816","DOI":"10.1038\/39807","volume":"389","author":"MJ Caterina","year":"1997","unstructured":"Caterina MJ, Schumacher MA, Tominaga M, Rosen TA, Levine JD, Julius D (1997) The capsaicin receptor: a heat-activated ion channel in the pain pathway. Nature 389:816\u2013824. https:\/\/doi.org\/10.1038\/39807","journal-title":"Nature"},{"key":"670_CR14","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1016\/0014-2999(94)90789-7","volume":"271","author":"YL Chen","year":"1994","unstructured":"Chen YL, Le Vraux V, Giroud JP, Chauvelot-Moachon L (1994) Anti-tumor necrosis factor properties of non-peptide drugs in acute-phase responses. Eur J Pharmacol 271:319\u2013327. https:\/\/doi.org\/10.1016\/0014-2999(94)90789-7","journal-title":"Eur J Pharmacol"},{"key":"670_CR15","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1016\/j.neulet.2013.02.005","volume":"541","author":"J Chen","year":"2013","unstructured":"Chen J, Song Y, Yang J, Zhang Y, Zhao P, Zhu XJ, Su HC (2013) The contribution of TNF-\u03b1 in the amygdala to anxiety in mice with persistent inflammatory pain. Neurosci Lett 541:275\u2013280. https:\/\/doi.org\/10.1016\/j.neulet.2013.02.005","journal-title":"Neurosci Lett"},{"key":"670_CR16","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1038\/nature12479","volume":"501","author":"IM Chiu","year":"2013","unstructured":"Chiu IM, Heesters BA, Ghasemlou N, Von Hehn CA, Zhao F, Tran J, Wainger B, Strominger A, Muralidharan S, Horswill AR, Bubeck Wardenburg J, Hwang SW, Carroll MC, Woolf CJ (2013) Bacteria activate neurons that modulate pain and inflammation. Nature 501:52\u201357. https:\/\/doi.org\/10.1038\/nature12479","journal-title":"Nature"},{"key":"670_CR17","first-page":"273","volume":"3","author":"BL Crabtree","year":"1984","unstructured":"Crabtree BL (1984) Review of naltrexone, a long-acting opiate antagonist. Clin Pharm 3:273\u2013280","journal-title":"Clin Pharm"},{"key":"670_CR18","doi-asserted-by":"publisher","first-page":"1418","DOI":"10.1038\/sj.bjp.0703434","volume":"130","author":"JM Cunha","year":"2000","unstructured":"Cunha JM, Cunha FQ, Poole S, Ferreira SH (2000) Cytokine-mediated inflammatory hyperalgesia limited by interleukin-1 receptor antagonist. Br J Pharmacol 130:1418\u20131424. https:\/\/doi.org\/10.1038\/sj.bjp.0703434","journal-title":"Br J Pharmacol"},{"key":"670_CR19","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1111\/j.2042-7158.1972.tb08940.x","volume":"24","author":"M Di Rosa","year":"1972","unstructured":"Di Rosa M (1972) Biological properties of carrageenan. J Pharm Pharmacol 24:89\u2013102. https:\/\/doi.org\/10.1111\/j.2042-7158.1972.tb08940.x","journal-title":"J Pharm Pharmacol"},{"key":"670_CR20","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1254\/jphs.94.161","volume":"94","author":"EN Duman","year":"2004","unstructured":"Duman EN, Kesim M, Kadioglu M, Yaris E, Kalyoncu NI, Erciyes N (2004) Possible involvement of opioidergic and serotonergic mechanisms in antinociceptive effect of paroxetine in acute pain. J Pharmacol Sci 94:161\u2013165. https:\/\/doi.org\/10.1254\/jphs.94.161","journal-title":"J Pharmacol Sci"},{"key":"670_CR21","doi-asserted-by":"publisher","first-page":"160","DOI":"10.1016\/j.ejphar.2015.10.047","volume":"768","author":"MM Dutra","year":"2015","unstructured":"Dutra MM, Nascimento J\u00fanior EB, Godin AM, Brito AM, Melo IS, Augusto PS, Rodrigues FF, Ara\u00fajo DP, de F\u00e1tima \u00c2, Coelho MM, Machado RR (2015) Opioid pathways activation mediates the activity of nicorandil in experimental models of nociceptive and inflammatory pain. Eur J Pharmacol 768:160\u2013164. https:\/\/doi.org\/10.1016\/j.ejphar.2015.10.047","journal-title":"Eur J Pharmacol"},{"key":"670_CR22","doi-asserted-by":"publisher","first-page":"101ra91","DOI":"10.1126\/scitranslmed.3002613","volume":"3","author":"MA Farmer","year":"2011","unstructured":"Farmer MA, Taylor AM, Bailey AL, Tuttle AH, MacIntyre LC, Milagrosa ZE, Crissman HP, Bennett GJ, Ribeiro-da-Silva A, Binik YM, Mogil JS (2011) Repeated vulvoginal fungal infections cause persistent pain in a mouse model of vulvodynia. Sci Transl Med 3:101ra91. https:\/\/doi.org\/10.1126\/scitranslmed.3002613","journal-title":"Sci Transl Med"},{"key":"670_CR23","doi-asserted-by":"publisher","first-page":"614","DOI":"10.1016\/j.phrs.2011.06.013","volume":"64","author":"TJ Federici","year":"2011","unstructured":"Federici TJ (2011) The non-antibiotic properties of tetracyclines: clinical potential in ophthalmic disease. Pharmacol Res 64:614\u2013623. https:\/\/doi.org\/10.1016\/j.phrs.2011.06.013","journal-title":"Pharmacol Res"},{"key":"670_CR24","doi-asserted-by":"publisher","first-page":"01","DOI":"10.1002\/0471141755.ph0504s56","volume":"5","author":"JC Fehrenbacher","year":"2012","unstructured":"Fehrenbacher JC, Vaski MR, Duarte DB (2012) Models of inflammation: carrageenan- or complete Freund's adjuvant (CFA)-induced edema and hypersensitivity in the rat. Curr Protoc Pharmacol 5:01\u201311. https:\/\/doi.org\/10.1002\/0471141755.ph0504s56","journal-title":"Curr Protoc Pharmacol"},{"key":"670_CR25","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1016\/j.applanim.2008.10.002","volume":"116","author":"B Gaskill","year":"2009","unstructured":"Gaskill B, Rohr SA, Pajor EA, Lucas JR, Garner JP (2009) Some like it hot: mouse temperature preferences in laboratory housing. Appl Animal Behav Sci 116:279\u2013285. https:\/\/doi.org\/10.1016\/j.applanim.2008.10.002","journal-title":"Appl Animal Behav Sci"},{"key":"670_CR26","doi-asserted-by":"publisher","first-page":"1137","DOI":"10.1128\/aac.37.5.1137","volume":"37","author":"G Gatti","year":"1993","unstructured":"Gatti G, Flaherty J, Bubp J, White J, Borin M, Gambertoglio J (1993) Comparative study of bioavailabilities and pharmacokinetics of clindamycin in healthy volunteers and patients with AIDS. Antimicrob Agents Chemother 37:1137\u20131143. https:\/\/doi.org\/10.1128\/aac.37.5.1137","journal-title":"Antimicrob Agents Chemother"},{"key":"670_CR27","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1016\/j.pbb.2014.04.008","volume":"122","author":"AM Godin","year":"2014","unstructured":"Godin AM, Ara\u00fajo DP, Menezes RR, Brito AM, Melo IS, Coura GM, Soares DG, Bastos LF, Amaral FA, Ribeiro LS, Boff D, Santos JR, Santos DA, Teixeira MM, de F\u00e1tima \u00c2, Machado RR, Coelho MM (2014) Activities of 2-phthalimidethanol and 2-phthalimidethyl nitrate, phthalimide analogs devoid of the glutarimide moiety, in experimental models of inflammatory pain and edema. Pharmacol Biochem Behav 122:291\u2013298. https:\/\/doi.org\/10.1016\/j.pbb.2014.04.008","journal-title":"Pharmacol Biochem Behav"},{"key":"670_CR28","doi-asserted-by":"publisher","first-page":"963","DOI":"10.1016\/0031-9384(90)90025-y","volume":"47","author":"CJ Gordon","year":"1990","unstructured":"Gordon CJ (1990) Thermal biology of the laboratory rat. Physiol Behav 47:963\u2013991. https:\/\/doi.org\/10.1016\/0031-9384(90)90025-y","journal-title":"Physiol Behav"},{"key":"670_CR29","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1016\/s0014-2999(02)02485-8","volume":"454","author":"H Guhring","year":"2002","unstructured":"Guhring H, Hamza M, Sergejeva M, Ates M, Kotalla CE, Ledent C, Brune K (2002) A role for endocannabinoids in indomethacin-induced spinal antinociception. Eur J Pharmacol 454:153\u2013163. https:\/\/doi.org\/10.1016\/s0014-2999(02)02485-8","journal-title":"Eur J Pharmacol"},{"key":"670_CR30","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1016\/j.pain.2005.12.007","volume":"121","author":"J Guindon","year":"2006","unstructured":"Guindon J, De L\u00e9an A, Beaulieu P (2006) Local interactions between anandamide, an endocannabinoid, and ibuprofen, a nonsteroidal anti-inflammatory drug, in acute and inflammatory pain. Pain 121:85\u201393. https:\/\/doi.org\/10.1016\/j.pain.2005.12.007","journal-title":"Pain"},{"key":"670_CR31","doi-asserted-by":"publisher","first-page":"1119","DOI":"10.1038\/sj.bjp.0701735","volume":"123","author":"RL Handy","year":"1998","unstructured":"Handy RL, Moore PK (1998) A comparison of the effects of L-NAME, 7-NI and L-NIL on carrageenan-induced hindpaw oedema and NOS activity. Br J Pharmacol 123:1119\u20131126. https:\/\/doi.org\/10.1038\/sj.bjp.0701735","journal-title":"Br J Pharmacol"},{"key":"670_CR32","doi-asserted-by":"publisher","first-page":"2638","DOI":"10.1128\/aac.45.9.2638-2642.2001","volume":"45","author":"N Hirata","year":"2001","unstructured":"Hirata N, Hiramatsu K, Kishi K, Yamasaki T, Ichimiya T, Nasu M (2001) Pretreatment of mice with clindamycin improves survival of endotoxic shock by modulating the release of inflammatory cytokines. Antimicrob Agents Chemother 45:2638\u20132642. https:\/\/doi.org\/10.1128\/aac.45.9.2638-2642.2001","journal-title":"Antimicrob Agents Chemother"},{"key":"670_CR33","doi-asserted-by":"publisher","first-page":"284","DOI":"10.1016\/j.neuroscience.2012.07.058","volume":"148","author":"Y Hu","year":"2010","unstructured":"Hu Y, Li W, Lu L, Cai J, Xian X, Zhang M, Li Q, Li L (2010) An antinociceptive role for ceftriaxone in chronic neuropathic pain in rats. Pain 148:284\u2013301. https:\/\/doi.org\/10.1016\/j.neuroscience.2012.07.058","journal-title":"Pain"},{"key":"670_CR34","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1016\/0014-2999(80)90515-4","volume":"67","author":"JL Hylden","year":"1980","unstructured":"Hylden JL, Wilcox GL (1980) Intrathecal morphine in mice: a new technique. Eur J Pharmacol 67:313\u2013316. https:\/\/doi.org\/10.1016\/0014-2999(80)90515-4","journal-title":"Eur J Pharmacol"},{"key":"670_CR35","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1093\/jac\/dkt374","volume":"69","author":"BN Kim","year":"2014","unstructured":"Kim BN, Kim ES, Oh MD (2014) Oral antibiotic treatment of staphylococcal bone and joint infections in adults. J Antimicrob Chemother 69:309\u2013322. https:\/\/doi.org\/10.1093\/jac\/dkt374","journal-title":"J Antimicrob Chemother"},{"key":"670_CR36","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1093\/jac\/12.suppl_c.39","volume":"12","author":"MS Klempner","year":"1983","unstructured":"Klempner MS, Styrt B (1983) Alkalinization of the intralysosomal pH by clindamycin and its effects on neutrophil function. J Antimicrob Chemother 12:39\u201350. https:\/\/doi.org\/10.1093\/jac\/12.suppl_c.39","journal-title":"J Antimicrob Chemother"},{"key":"670_CR37","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1038\/nri3399","volume":"13","author":"E Kolaczkowska","year":"2013","unstructured":"Kolaczkowska E, Kubes P (2013) Neutrophil recruitment and function in health and inflammation. Nat Rev Immunol 13:159\u2013175. https:\/\/doi.org\/10.1038\/nri3399","journal-title":"Nat Rev Immunol"},{"key":"670_CR38","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1016\/0006-8993(88)90469-6","volume":"458","author":"LM Konopka","year":"1988","unstructured":"Konopka LM, Parsons RL (1988) Clindamycin induced alteration of ganglionic function. I. Direct effects on ganglion cell properties. Brain Res 458:269\u2013277. https:\/\/doi.org\/10.1016\/0006-8993(88)90469-6","journal-title":"Brain Res"},{"key":"670_CR39","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1007\/s40278-015-10441-5","volume":"3","author":"MT Labro","year":"2002","unstructured":"Labro MT (2002) Antibiotics as anti-inflammatory agents. Curr Opin Investig Drugs 3:61\u201368. https:\/\/doi.org\/10.1007\/s40278-015-10441-5","journal-title":"Curr Opin Investig Drugs"},{"key":"670_CR40","doi-asserted-by":"publisher","first-page":"e5682","DOI":"10.1097\/MD.0000000000005682","volume":"95","author":"Y Li","year":"2016","unstructured":"Li Y, Zhou Q, Liu Y, Chen W, Li J, Yuan Z, Yong B, Xu H (2016) Delayed treatment of septic arthritis in the neonate: a review of 52 cases. Medicine (Baltimore) 95:e5682. https:\/\/doi.org\/10.1097\/MD.0000000000005682","journal-title":"Medicine (Baltimore)"},{"key":"670_CR41","doi-asserted-by":"publisher","first-page":"2895","DOI":"10.1073\/pnas.73.8.2895","volume":"73","author":"HH Loh","year":"1976","unstructured":"Loh HH, Tseng LF, Wei E, Li CH (1976) Beta-endorphin is a potent analgesic agent. Proc Natl Acad Sci USA 73:2895\u20132898. https:\/\/doi.org\/10.1073\/pnas.73.8.2895","journal-title":"Proc Natl Acad Sci USA"},{"key":"670_CR42","doi-asserted-by":"publisher","first-page":"520","DOI":"10.1056\/NEJM199808203390806","volume":"339","author":"FD Lowy","year":"1998","unstructured":"Lowy FD (1998) Staphylococcus aureus infections. N Engl J Med 339:520\u2013532. https:\/\/doi.org\/10.1056\/NEJM199808203390806","journal-title":"N Engl J Med"},{"key":"670_CR43","first-page":"1521","volume-title":"Goodman and Gilman\u2019s The Pharmacological Basis of Therapeutics","author":"C MacDougal","year":"2011","unstructured":"MacDougal C, Chambers HF (2011) Protein synthesis inhibitors and miscellaneous antibacterial agents. Goodman and Gilman\u2019s The Pharmacological Basis of Therapeutics, 12th edn. McGraw-Hill, New York, pp 1521\u20131547","edition":"12"},{"key":"670_CR44","doi-asserted-by":"publisher","first-page":"306","DOI":"10.1016\/j.isci.2018.08.007","volume":"6","author":"K Maruyama","year":"2018","unstructured":"Maruyama K, Takayama Y, Sugisawa E, Yamanoi Y, Yokawa T, Kondo T, Ishibashi KI, Sahoo BR, Takemura N, Mori Y, Kanemaru H, Kumagai Y, Martino MM, Yoshioka Y, Nishijo H, Tanaka H, Sasaki A, Ohno N, Iwakura Y, Moriyama Y, Nomura M, Akira S, Tominaga M (2018) The ATP transporter VNUT mediates induction of dectin-1 triggered Candida nociception. iScience 6:306\u2013318. https:\/\/doi.org\/10.1016\/j.isci.2018.08.007","journal-title":"iScience"},{"key":"670_CR45","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1111\/j.1365-2249.2008.03669.x","volume":"153","author":"E Mazzon","year":"2008","unstructured":"Mazzon E, Esposito E, Di Paola R, Mui\u00e0 C, Crisafulli C, Genovese T, Caminiti R, Meli R, Bramanti P, Cuzzocrea S (2008) Effect of tumour necrosis factor-alpha receptor 1 genetic deletion on carrageenan-induced acute inflammation: a comparison with etanercept. Clin Exp Immunol 153:136\u2013149. https:\/\/doi.org\/10.1111\/j.1365-2249.2008.03669.x","journal-title":"Clin Exp Immunol"},{"key":"670_CR46","doi-asserted-by":"publisher","first-page":"428","DOI":"10.1038\/nature07201","volume":"454","author":"R Medzhitov","year":"2008","unstructured":"Medzhitov R (2008) Origin and physiological roles of inflammation. Nature 454:428\u2013435. https:\/\/doi.org\/10.1038\/nature07201","journal-title":"Nature"},{"key":"670_CR47","doi-asserted-by":"publisher","first-page":"697","DOI":"10.1016\/0306-3623(83)90172-6","volume":"14","author":"E Mesdjian","year":"1983","unstructured":"Mesdjian E, DeFeudis FV, Valli M, Jadot G, Mandel P (1983) Antinociceptive action of sodium valproate in the mouse. Gen Pharmacol 14:697\u2013699. https:\/\/doi.org\/10.1016\/0306-3623(83)90172-6","journal-title":"Gen Pharmacol"},{"key":"670_CR48","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1016\/j.ejphar.2018.02.014","volume":"824","author":"MI Morais","year":"2018","unstructured":"Morais MI, Rodrigues FF, Costa SOAM, Goulart FA, Costa FC, Melo ISF, Augusto PSA, Dutra MMGB, de F\u00e1tima \u00c2, Coelho MM, Machado RR (2018) Nicorandil inhibits tactile hypersensitivity induced by paclitaxel by activating opioidergic and serotonergic mechanisms. Eur J Pharmacol 824:108\u2013114. https:\/\/doi.org\/10.1016\/j.ejphar.2018.02.014","journal-title":"Eur J Pharmacol"},{"key":"670_CR49","doi-asserted-by":"publisher","first-page":"254.e1","DOI":"10.1016\/j.cmi.2014.09.007","volume":"21","author":"O Murillo","year":"2015","unstructured":"Murillo O, Grau I, Lora-Tamayo J, Gomez-Junyent J, Ribera A, Tubau F, Ariza J, Pallares R (2015) The changing epidemiology of bacteraemic osteoarticular infections in the early 21st century. Clin Microbiol Infect 21:254.e1\u20138. https:\/\/doi.org\/10.1016\/j.cmi.2014.09.007","journal-title":"Clin Microbiol Infect"},{"key":"670_CR50","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1111\/j.1476-5381.1996.tb15205.x","volume":"117","author":"A Nakamura","year":"1996","unstructured":"Nakamura A, Fujita M, Shiomi H (1996) Involvement of endogenous nitric oxide in the mechanism of bradykinin-induced peripheral hyperalgesia. Br J Pharmacol 117:407\u2013412. https:\/\/doi.org\/10.1111\/j.1476-5381.1996.tb15205.x","journal-title":"Br J Pharmacol"},{"key":"670_CR51","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1128\/aac.47.1.363-367.2003","volume":"47","author":"T Nakano","year":"2003","unstructured":"Nakano T, Hiramatsu K, Kishi K, Hirato N, Kadota J, Nasu M (2003) Clindamycin modulates inflammatory-cytokine induction in lipopolysaccharide-stimulated mouse peritoneal macrophages. Antimicrob Agents Chemother 47:363\u2013367. https:\/\/doi.org\/10.1128\/aac.47.1.363-367.2003","journal-title":"Antimicrob Agents Chemother"},{"key":"670_CR52","doi-asserted-by":"publisher","first-page":"15208","DOI":"10.1074\/jbc.M611907200","volume":"282","author":"M Nikodemova","year":"2007","unstructured":"Nikodemova M, Watters JJ, Jackson SJ, Yang SK, Duncan ID (2007) Minocycline down-regulates MHC II expression in microglia and macrophages through inhibition of IRF-1 and protein kinase C (PKC) alpha\/beta II. J Biol Chem 282:15208\u201315216. https:\/\/doi.org\/10.1074\/jbc.M611907200","journal-title":"J Biol Chem"},{"issue":"Suppl 1","key":"670_CR53","doi-asserted-by":"publisher","first-page":"S10","DOI":"10.1016\/j.jpain.2007.10.003","volume":"1","author":"AL Oaklander","year":"2008","unstructured":"Oaklander AL (2008) Mechanisms of pain and itch caused by herpes zoster (shingles). J Pain 1(Suppl 1):S10\u2013S18. https:\/\/doi.org\/10.1016\/j.jpain.2007.10.003","journal-title":"J Pain"},{"key":"670_CR54","doi-asserted-by":"publisher","first-page":"1201","DOI":"10.1097\/INF.0000000000001697","volume":"36","author":"L Olarte","year":"2017","unstructured":"Olarte L, Romero J, Barson W, Bradley J, Lin PL, Givner L, Tan T, Hoffman J, Hult\u00e9n KG, Mason EO, Kaplan SL (2017) Osteoarticular infections caused by Streptococcus pneumoniae in children in the post-pneumococcal conjugate vaccine era. Pediatr Infect Dis J 36:1201\u20131204. https:\/\/doi.org\/10.1097\/INF.0000000000001697","journal-title":"Pediatr Infect Dis J"},{"key":"670_CR55","doi-asserted-by":"publisher","first-page":"582","DOI":"10.1111\/j.1469-0691.2011.03643.x","volume":"18","author":"Peltola H, P\u00e4\u00e4kk\u00f6nen M, Kallio P, Kallio MJ; OM-SA Study Group","year":"2012","unstructured":"Peltola H, P\u00e4\u00e4kk\u00f6nen M, Kallio P, Kallio MJ; OM-SA Study Group (2012) Clindamycin vs. first-generation cephalosporins for acute osteoarticular infections of childhood\u2014a prospective quasi-randomized controlled trial. Clin Microbiol Infect 18:582\u2013589. https:\/\/doi.org\/10.1111\/j.1469-0691.2011.03643.x","journal-title":"Clin Microbiol Infect"},{"key":"670_CR56","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1007\/BF01641675","volume":"12","author":"H Peltola","year":"1984","unstructured":"Peltola H, Vahvanen VA (1984) Comparative study of osteomyelitis and purulent arthritis with special reference to aetiology and recovery. Infection 12:75\u201379. https:\/\/doi.org\/10.1007\/BF01641675","journal-title":"Infection"},{"key":"670_CR57","doi-asserted-by":"publisher","first-page":"S13","DOI":"10.1038\/sj.ijo.0803272","volume":"1","author":"RG Pertwee","year":"2006","unstructured":"Pertwee RG (2006) The pharmacology of cannabinoid receptors and their ligands: an overview. Int J Obes (Lond) 1:S13\u2013S18. https:\/\/doi.org\/10.1038\/sj.ijo.0803272","journal-title":"Int J Obes (Lond)"},{"key":"670_CR58","first-page":"1170","volume":"255","author":"C Prior","year":"1990","unstructured":"Prior C, Fiekers JF, Henderson F, Dempster J, Marshall IG, Parsons RL (1990) End-plate ion channel block produced by lincosamide antibiotics and their chemical analogs. J Pharmacol Exp Ther 255:1170\u20131176","journal-title":"J Pharmacol Exp Ther"},{"key":"670_CR59","doi-asserted-by":"publisher","first-page":"1888","DOI":"10.1016\/j.neuroscience.2010.06.014","volume":"169","author":"KM Ramos","year":"2010","unstructured":"Ramos KM, Lewis MT, Morgan KN, Crysdale NY, Kroll JL, Taylor FR, Harrison JA, Sloane EM, Maier SF, Watkins LR (2010) Spinal upregulation of glutamate transporter GLT-1 by ceftriaxone: therapeutic efficacy in a range of experimental nervous system disorders. Neuroscience 169:1888\u20131900. https:\/\/doi.org\/10.1016\/j.neuroscience.2010.06.014","journal-title":"Neuroscience"},{"key":"670_CR60","doi-asserted-by":"publisher","first-page":"1267","DOI":"10.1038\/nm.2234","volume":"16","author":"K Ren","year":"2010","unstructured":"Ren K, Dubner R (2010) Interactions between the immune and nervous systems in pain. Nat Med 16:1267\u20131276. https:\/\/doi.org\/10.1038\/nm.2234","journal-title":"Nat Med"},{"key":"670_CR61","doi-asserted-by":"publisher","first-page":"4593","DOI":"10.1128\/IAI.00798-10","volume":"78","author":"AM Ritzman","year":"2010","unstructured":"Ritzman AM, Hughes-Hanks JM, Blaho VA, Wax LE, Mitchell WJ, Brown CR (2010) The chemokine receptor CXCR2 ligand KC (CXCL1) mediates neutrophil recruitment and is critical for development of experimental Lyme arthritis and carditis. Infect Immun 78:4593\u20134600. https:\/\/doi.org\/10.1128\/IAI.00798-10","journal-title":"Infect Immun"},{"key":"670_CR62","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1038\/sj.bjp.0703038","volume":"129","author":"AR Rodrigues","year":"2000","unstructured":"Rodrigues AR, Duarte ID (2000) The peripheral antinociceptive effect induced by morphine is associated with ATP-sensitive K(+) channels. Br J Pharmacol 129:110\u2013114. https:\/\/doi.org\/10.1038\/sj.bjp.0703038","journal-title":"Br J Pharmacol"},{"key":"670_CR63","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1590\/s0100-879x2005000100014","volume":"38","author":"AR Rodrigues","year":"2005","unstructured":"Rodrigues AR, Castro MS, Francischi JN, Perez AC, Duarte ID (2005) Participation of ATP-sensitive K+ channels in the peripheral antinociceptive effect of fentanyl in rats. Braz J Med Biol Res 38:91\u201397. https:\/\/doi.org\/10.1590\/s0100-879x2005000100014","journal-title":"Braz J Med Biol Res"},{"key":"670_CR64","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1016\/j.brainres.2013.02.030","volume":"1506","author":"TR Romero","year":"2013","unstructured":"Romero TR, Pacheco DF, Duarte ID (2013) Xylazine induced central antinociception mediated by endogenous opioids and \u03bc-opioid receptor, but not \u03b4- or \u03ba-opioid receptors. Brain Res 1506:58\u201363. https:\/\/doi.org\/10.1016\/j.brainres.2013.02.030","journal-title":"Brain Res"},{"key":"670_CR65","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1016\/0304-3959(88)90295-3","volume":"33","author":"JH Rosland","year":"1988","unstructured":"Rosland JH, Hunskaar S, Hole K (1988) Modification of the antinociceptive effect of morphine by acute and chronic administration of clomipramine in mice. Pain 33:349\u2013355. https:\/\/doi.org\/10.1016\/0304-3959(88)90295-3","journal-title":"Pain"},{"key":"670_CR66","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1093\/jac\/26.suppl_C.31","volume":"1","author":"BK Rubin","year":"2000","unstructured":"Rubin BK, Tamaoki J (2000) Macrolide antibiotics as biological response modifiers. Curr Op Investig Drugs 1:169\u2013172. https:\/\/doi.org\/10.1093\/jac\/26.suppl_C.31","journal-title":"Curr Op Investig Drugs"},{"key":"670_CR67","doi-asserted-by":"publisher","first-page":"446","DOI":"10.1099\/jmm.0.000026","volume":"64","author":"CD Russell","year":"2015","unstructured":"Russell CD, Ramaesh R, Kalima P, Murray A, Gaston MS (2015) Microbiological characteristics of acute osteoarticular infections in children. J Med Microbiol 64:446\u2013453. https:\/\/doi.org\/10.1099\/jmm.0.000026","journal-title":"J Med Microbiol"},{"key":"670_CR68","doi-asserted-by":"publisher","first-page":"507","DOI":"10.1016\/j.pain.2007.10.013","volume":"137","author":"I Sabsovich","year":"2008","unstructured":"Sabsovich I, Guo TZ, Wei T, Zhao R, Li X, Clark DJ, Geis C, Sommer C, Kingery WS (2008) TNF signaling contributes to the development of nociceptive sensitization in a tibia fracture model of complex regional pain syndrome type I. Pain 137:507\u2013519. https:\/\/doi.org\/10.1016\/j.pain.2007.10.013","journal-title":"Pain"},{"key":"670_CR69","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1016\/j.bcp.2016.12.001","volume":"133","author":"J Sp\u00ed\u017eek","year":"2017","unstructured":"Sp\u00ed\u017eek J, \u0158ezanka T (2017) Lincosamides: chemical structure, biosynthesis, mechanism of action, resistance, and applications. Biochem Pharmacol 133:20\u201328. https:\/\/doi.org\/10.1016\/j.bcp.2016.12.001","journal-title":"Biochem Pharmacol"},{"key":"670_CR70","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1016\/0091-3057(88)90372-3","volume":"31","author":"C Stein","year":"1998","unstructured":"Stein C, Millan MJ, Herz A (1998) Unilateral inflammation of the hindpaw in rats as a model of prolonged noxious stimulation: alterations in behavior and nociceptive thresholds. Pharmacol Biochem Behav 31:445\u2013451. https:\/\/doi.org\/10.1016\/0091-3057(88)90372-3","journal-title":"Pharmacol Biochem Behav"},{"key":"670_CR71","doi-asserted-by":"publisher","first-page":"e10","DOI":"10.1093\/cid\/ciu444","volume":"59","author":"DL Stevens","year":"2014","unstructured":"Stevens DL, Bisno AL, Chambers HF, Dellinger EP, Goldstein EJ, Gorbach SL, Hirschmann JV, Kaplan SL, Montoya JG, Wade JC (2014) Infectious Diseases Society of America, Practice guidelines for the diagnosis and management of skin and soft tissue infections: 2014 update by the Infectious Diseases Society of America. Clin Infect Dis 59:e10\u201352. https:\/\/doi.org\/10.1093\/cid\/ciu444","journal-title":"Clin Infect Dis"},{"key":"670_CR72","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1016\/0014-2999(94)90398-0","volume":"251","author":"CR Tonussi","year":"1994","unstructured":"Tonussi CR, Ferreira SH (1994) Mechanism of diclofenac analgesia: direct blockade of inflammatory sensitization. Eur J Pharmacol 251:173\u2013179. https:\/\/doi.org\/10.1016\/0014-2999(94)90398-0","journal-title":"Eur J Pharmacol"},{"key":"670_CR73","doi-asserted-by":"publisher","first-page":"662","DOI":"10.1038\/nature26137","volume":"555","author":"I Vandewauw","year":"2018","unstructured":"Vandewauw I, De Clercq K, Mulier M, Held K, Pinto S, Van Ranst N, Segal A, Voet T, Vennekens R, Zimmermann K, Vriens J, Voets T (2018) A TRP channel trio mediates acute noxious heat sensing. Nature 555:662\u2013666. https:\/\/doi.org\/10.1038\/nature26137","journal-title":"Nature"},{"key":"670_CR74","first-page":"118","volume":"46","author":"R Vinegar","year":"1987","unstructured":"Vinegar R, Truax JF, Selph JL, Johnston PR, Venable AL, McKenzie KK (1987) Pathway to carrageenan-induced inflammation in the hind limb of the rat. Fed Proc 46:118\u2013126","journal-title":"Fed Proc"},{"key":"670_CR75","doi-asserted-by":"publisher","first-page":"2713","DOI":"10.1096\/fj.12-222992","volume":"27","author":"X Wang","year":"2013","unstructured":"Wang X, Grace PM, Pham MN, Cheng K, Strand KA, Smith C, Li J, Watkins LR, Yin H (2013) Rifampin inhibits Toll-like receptor 4 signaling by targeting myeloid differentiation protein 2 and attenuates neuropathic pain. FASEB J 27:2713\u20132722. https:\/\/doi.org\/10.1096\/fj.12-222992","journal-title":"FASEB J"},{"key":"670_CR76","doi-asserted-by":"publisher","first-page":"7710","DOI":"10.1073\/pnas.96.14.7710","volume":"96","author":"LR Watkins","year":"1999","unstructured":"Watkins LR, Maier SF (1999) Implications of immune-to-brain communication for sickness and pain. Proc Natl Acad Sci USA 96:7710\u20137713. https:\/\/doi.org\/10.1073\/pnas.96.14.7710","journal-title":"Proc Natl Acad Sci USA"},{"key":"670_CR77","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/j.ijpharm.2006.11.019","volume":"332","author":"SH Yang","year":"2007","unstructured":"Yang SH, Lee MG (2007) Dose-independent pharmacokinetics of clindamycin after intravenous and oral administration to rats: contribution of gastric first-pass effect to low bioavailability. Int J Pharm 332:17\u201323. https:\/\/doi.org\/10.1016\/j.ijpharm.2006.11.019","journal-title":"Int J Pharm"},{"key":"670_CR78","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1016\/j.pain.2010.11.014","volume":"152","author":"L Zhang","year":"2011","unstructured":"Zhang L, Berta T, Xu ZZ, LiuT PJY, Ji RR (2011) TNF-\u03b1 contributes to spinal cord synaptic plasticity and inflammatory pain: distinct role of TNF receptor subtypes 1 and 2. Pain 152:419\u2013427. https:\/\/doi.org\/10.1016\/j.pain.2010.11.014","journal-title":"Pain"},{"key":"670_CR79","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1016\/0304-3959(83)90201-4","volume":"16","author":"M Zimmermann","year":"1983","unstructured":"Zimmermann M (1983) Ethical guidelines for investigations of experimental pain in conscious animals. Pain 16:109\u2013110. https:\/\/doi.org\/10.1016\/0304-3959(83)90201-4","journal-title":"Pain"}],"container-title":["Inflammopharmacology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10787-019-00670-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10787-019-00670-w\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10787-019-00670-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,11,24]],"date-time":"2020-11-24T00:55:08Z","timestamp":1606179308000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10787-019-00670-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,11,25]]},"references-count":79,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2020,4]]}},"alternative-id":["670"],"URL":"https:\/\/doi.org\/10.1007\/s10787-019-00670-w","relation":{},"ISSN":["0925-4692","1568-5608"],"issn-type":[{"value":"0925-4692","type":"print"},{"value":"1568-5608","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,11,25]]},"assertion":[{"value":"26 July 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 November 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 November 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}