{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T22:56:54Z","timestamp":1788217014061,"version":"build-2803163510"},"reference-count":92,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2020,6,25]],"date-time":"2020-06-25T00:00:00Z","timestamp":1593043200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,6,25]],"date-time":"2020-06-25T00:00:00Z","timestamp":1593043200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Inflammopharmacol"],"published-print":{"date-parts":[[2020,12]]},"DOI":"10.1007\/s10787-020-00733-3","type":"journal-article","created":{"date-parts":[[2020,6,25]],"date-time":"2020-06-25T13:02:43Z","timestamp":1593090163000},"page":"1599-1622","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Oral administration of Centella asiatica (L.) Urb leave aqueous extract ameliorates cerebral oxidative stress, inflammation, and apoptosis in male rats with type-2 diabetes"],"prefix":"10.1007","volume":"28","author":[{"given":"Nelli","family":"Giribabu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kamarulzaman","family":"Karim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eswar Kumar","family":"Kilari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Srinivasa Rao","family":"Nelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4926-0490","authenticated-orcid":false,"given":"Naguib","family":"Salleh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,6,25]]},"reference":[{"key":"733_CR1","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1016\/j.biopha.2016.04.032","volume":"81","author":"SH Adam","year":"2016","unstructured":"Adam SH, Giribabu N, Kassim N, Kumar KE, Brahmayya M, Arya A, Salleh N (2016) Protective effect of aqueous seed extract of Vitis Vinifera against oxidative stress, inflammation and apoptosis in the pancreas of adult male rats with diabetes mellitus. Biomed Pharmacotherap 81:439\u2013452. https:\/\/doi.org\/10.1016\/j.biopha.2016.04.032","journal-title":"Biomed Pharmacotherap"},{"key":"733_CR2","doi-asserted-by":"publisher","first-page":"318","DOI":"10.1016\/j.sjopt.2018.05.002","volume":"32","author":"AS Al-Kharashi","year":"2018","unstructured":"Al-Kharashi AS (2018) Role of oxidative stress, inflammation, hypoxia and angiogenesis in the development of diabetic retinopathy. Saudi J Ophthalmol 32:318\u2013323. https:\/\/doi.org\/10.1016\/j.sjopt.2018.05.002","journal-title":"Saudi J Ophthalmol"},{"key":"733_CR3","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1007\/s11064-011-0588-x","volume":"37","author":"R Alvarez-N\u00f6lting","year":"2012","unstructured":"Alvarez-N\u00f6lting R, Arnal E, Barcia JM, Miranda M, Romero FJ (2012) Protection by DHA of early hippocampal changes in diabetes: possible role of CREB and NF-\u03baB. Neurochem Res 37:105\u2013115","journal-title":"Neurochem Res"},{"key":"733_CR4","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1016\/j.biopha.2017.02.026","volume":"89","author":"MSA Aziz","year":"2017","unstructured":"Aziz MSA, Giribabu N, Rao PV, Salleh N (2017) Pancreatoprotective effects of Geniotrigona thoracica stingless bee honey in streptozotocin-nicotinamide-induced male diabetic rats. Biomed Pharmacotherap 89:135\u2013145. https:\/\/doi.org\/10.1016\/j.biopha.2017.02.026","journal-title":"Biomed Pharmacotherap"},{"key":"733_CR5","doi-asserted-by":"crossref","first-page":"2792","DOI":"10.2337\/diabetes.50.12.2792","volume":"50","author":"A Bierhaus","year":"2001","unstructured":"Bierhaus A et al (2001) Diabetes-associated sustained activation of the transcription factor nuclear factor-kappaB. Diabetes 50:2792\u20132808","journal-title":"Diabetes"},{"key":"733_CR6","doi-asserted-by":"publisher","unstructured":"Biessels GJ, Ryan CM (2017) 4.22 - Cognitive Dysfunction in Diabetes Mellitus A2 - Pfaff, Donald W. In: Jo\u00ebls M (ed) Hormones, Brain and Behavior (Third Edition). Academic Press, Oxford, pp 421\u2013443. https:\/\/doi.org\/10.1016\/B978-0-12-803592-4.00088-2","DOI":"10.1016\/B978-0-12-803592-4.00088-2"},{"key":"733_CR7","first-page":"257","volume":"1","author":"SL Bonting","year":"1970","unstructured":"Bonting SL (1970) Sodium-potassium activated adenosine triphosphatase and cation transport. Membr Ion Transp 1:257\u2013363","journal-title":"Membr Ion Transp"},{"key":"733_CR8","doi-asserted-by":"crossref","unstructured":"Cai D, Liu T (2012) Inflammatory cause of metabolic syndrome via brain stress and NF-\u03baB Aging (Albany NY) 4:98","DOI":"10.18632\/aging.100431"},{"key":"733_CR9","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1007\/s11011-014-9631-3","volume":"30","author":"Z Cai","year":"2015","unstructured":"Cai Z, Xiao M, Chang L, Yan L-J (2015) Role of insulin resistance in Alzheimer\u2019s disease. Metab Brain Dis 30:839\u2013851","journal-title":"Metab Brain Dis"},{"key":"733_CR10","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1016\/bs.afnr.2015.08.001","volume":"76","author":"UG Chandrika","year":"2015","unstructured":"Chandrika UG, Prasad Kumarab PA (2015) Gotu Kola (Centella asiatica): nutritional properties and plausible health benefits. Adv Food Nutr Res 76:125\u2013157. https:\/\/doi.org\/10.1016\/bs.afnr.2015.08.001","journal-title":"Adv Food Nutr Res"},{"key":"733_CR11","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1002\/jnr.20899","volume":"84","author":"X Cui","year":"2006","unstructured":"Cui X et al (2006) Chronic systemic D-galactose exposure induces memory loss, neurodegeneration, and oxidative damage in mice: protective effects of R-\u03b1-lipoic acid. J Neurosci Res 84:647\u2013654","journal-title":"J Neurosci Res"},{"key":"733_CR12","first-page":"85","volume":"10","author":"GR de Lores Arnaiz","year":"2014","unstructured":"de Lores Arnaiz GR, Ordieres MGL (2014) Brain Na(+), K(+)-ATPase activity in aging and disease. IJBS 10:85\u2013102","journal-title":"IJBS"},{"key":"733_CR13","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1002\/ptr.2405","volume":"23","author":"M Dhanasekaran","year":"2009","unstructured":"Dhanasekaran M, Holcomb LA, Hitt AR, Tharakan B, Porter JW, Young KA, Manyam BV (2009) Centella asiatica extract selectively decreases amyloid \u03b2 levels in hippocampus of Alzheimer's disease animal model. Phytotherapy Res 23:14\u201319","journal-title":"Phytotherapy Res"},{"key":"733_CR14","first-page":"49","volume":"30","author":"AA Elmarakby","year":"2012","unstructured":"Elmarakby AA (2012) Sullivan JCJCt. Relationship between oxidative stress and inflammatory cytokines in diabetic nephropathy 30:49\u201359","journal-title":"Relationship between oxidative stress and inflammatory cytokines in diabetic nephropathy"},{"key":"733_CR15","doi-asserted-by":"publisher","first-page":"2795915","DOI":"10.1155\/2016\/2795915","volume":"2016","author":"KM Farhana","year":"2016","unstructured":"Farhana KM, Malueka RG (2016) Effectiveness of Gotu Kola extract 750 mg and 1000 mg compared with folic acid 3 mg in improving vascular cognitive impairment after. Stroke 2016:2795915. https:\/\/doi.org\/10.1155\/2016\/2795915","journal-title":"Stroke"},{"key":"733_CR16","unstructured":"Gayathri V, Lekshmi P, Padmanabhan RJIJoM, Plants A (2011) Anti-diabetes activity of ethanol extract of Centella asiatica (L.) Urban (whole plant) in Streptozotocin-induced diabetic rats, isolation of an active fraction and toxicity evaluation of the extract 1:278\u2013286"},{"key":"733_CR17","doi-asserted-by":"crossref","unstructured":"Giribabu N, Eswar Kumar K, Swapna Rekha S (2015) Vitis vinifera (Muscat Variety) Seed Ethanolic Extract Preserves Activity Levels of Enzymes and Histology of the Liver in Adult Male Rats with Diabetes 2015:542026. doi:10.1155\/2015\/542026","DOI":"10.1155\/2015\/542026"},{"key":"733_CR18","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcjd.2017.04.005","author":"N Giribabu","year":"2017","unstructured":"Giribabu N, Karim K, Kilari EK, Kassim NM, Salleh N (2017) Anti-Inflammatory, anti-apoptotic and pro-proliferative effects of Vitis Vinifera Seed Ethanolic extract in the liver of streptozotocin-nicotinamide-induced diabetes in male rats. Can J Diabetes. https:\/\/doi.org\/10.1016\/j.jcjd.2017.04.005","journal-title":"Can J Diabetes"},{"key":"733_CR19","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1186\/1472-6882-14-291","volume":"14","author":"N Giribabu","year":"2014","unstructured":"Giribabu N, Kumar KE, Rekha SS, Muniandy S, Salleh N (2014a) Chlorophytum borivilianum (Safed Musli) root extract prevents impairment in characteristics and elevation of oxidative stress in sperm of streptozotocin-induced adult male diabetic Wistar rats. BMC Complement Altern Med 14:291. https:\/\/doi.org\/10.1186\/1472-6882-14-291","journal-title":"BMC Complement Altern Med"},{"key":"733_CR20","doi-asserted-by":"publisher","first-page":"1172","DOI":"10.7150\/ijms.9056","volume":"11","author":"N Giribabu","year":"2014","unstructured":"Giribabu N, Kumar KE, Rekha SS, Muniandy S, Salleh N (2014b) Chlorophytum borivilianum root extract maintains near normal blood glucose, insulin and lipid profile levels and prevents oxidative stress in the pancreas of streptozotocin-induced adult male diabetic rats. Int J Med Sci 11:1172\u20131184. https:\/\/doi.org\/10.7150\/ijms.9056","journal-title":"Int J Med Sci"},{"key":"733_CR21","doi-asserted-by":"crossref","unstructured":"Giribabu N, Srinivasarao N, Swapna Rekha S, Muniandy S, Salleh N (2014c) Centella asiatica attenuates diabetes induced hippocampal changes in experimental diabetic rats. Evidence-Based Complement Altern Med 2014","DOI":"10.1155\/2014\/592062"},{"key":"733_CR22","doi-asserted-by":"publisher","first-page":"259","DOI":"10.4161\/derm.22028","volume":"4","author":"P Gkogkolou","year":"2012","unstructured":"Gkogkolou P, B\u00f6hm M (2012) Advanced glycation end products: Key players in skin aging? Dermato-endocrinology 4:259\u2013270. https:\/\/doi.org\/10.4161\/derm.22028","journal-title":"Dermato-endocrinology"},{"key":"733_CR23","doi-asserted-by":"crossref","first-page":"546","DOI":"10.4103\/0250-474X.78519","volume":"72","author":"K Gohil","year":"2010","unstructured":"Gohil K, Patel J, Gajjar A (2010) Pharmacological review on Centella asiatica: a potential herbal cure-all. Indian J Pharma Sci 72:546","journal-title":"Indian J Pharma Sci"},{"key":"733_CR24","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1016\/j.freeradbiomed.2017.12.013","volume":"115","author":"W Gong","year":"2018","unstructured":"Gong W, Chen Z, Zou Y, Zhang L, Huang J, Liu P, Huang H (2018) CKIP-1 affects the polyubiquitination of Nrf2 and Keap1 via mediating Smurf1 to resist HG-induced renal fibrosis in GMCs and diabetic mice kidneys. Free Radical Biol Med 115:338\u2013350","journal-title":"Free Radical Biol Med"},{"key":"733_CR25","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.neulet.2017.09.033","volume":"663","author":"P Hajieva","year":"2018","unstructured":"Hajieva P, Baeken MW, Moosmann B (2018) The role of plasma membrane calcium atpases (PMCAS) in neurodegenerative disorders. Neurosci Lett 663:29\u201338","journal-title":"Neurosci Lett"},{"key":"733_CR26","doi-asserted-by":"crossref","unstructured":"Halimi ES (2012) Identification of Agronomic Traits of Centella asiatica (L.) Urban. Naturally Grown at Regions With Different Altitudes Jurnal Natur Indonesia 13","DOI":"10.31258\/jnat.13.3.232-236"},{"key":"733_CR27","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/0003-2697(87)90222-3","volume":"165","author":"B Halliwell","year":"1987","unstructured":"Halliwell B, Gutteridge J, Aruoma OI (1987) The deoxyribose method: a simple \u201ctest-tube\u201d assay for determination of rate constants for reactions of hydroxyl radicals. Anal Biochem 165:215\u2013219","journal-title":"Anal Biochem"},{"key":"733_CR28","doi-asserted-by":"crossref","unstructured":"Hjert\u00e9n S, Pan H (1983) Purification and characterization of two forms of a low-affinity Ca2+-ATPase from erythrocyte membranes. Biochim Biophys Acta (BBA) Biomemb 728:281\u2013288","DOI":"10.1016\/0005-2736(83)90480-7"},{"key":"733_CR29","doi-asserted-by":"crossref","unstructured":"Hu T, Shi J-J, Fang J, Wang Q, Chen Y-B, Zhang S-JJA (2020) Quercetin ameliorates diabetic encephalopathy through SIRT1\/ER stress pathway in db\/db mice 12:7015","DOI":"10.18632\/aging.103059"},{"key":"733_CR30","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.brainres.2005.05.043","volume":"1052","author":"L Hui","year":"2005","unstructured":"Hui L, Pei D-S, Zhang Q-G, Guan Q-H, Zhang G-Y (2005) The neuroprotection of insulin on ischemic brain injury in rat hippocampus through negative regulation of JNK signaling pathway by PI3K\/Akt activation. Brain Res 1052:1\u20139","journal-title":"Brain Res"},{"key":"733_CR31","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1016\/j.pestbp.2018.08.008","volume":"152","author":"RM Hussein","year":"2018","unstructured":"Hussein RM, Mohamed WR, Omar HA (2018) A neuroprotective role of kaempferol against chlorpyrifos-induced oxidative stress and memory deficits in rats via GSK3beta-Nrf2 signaling pathway. Pestic Biochem Physiol 152:29\u201337. https:\/\/doi.org\/10.1016\/j.pestbp.2018.08.008","journal-title":"Pestic Biochem Physiol"},{"key":"733_CR32","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1186\/1472-6882-14-32","volume":"14","author":"F Hussin","year":"2014","unstructured":"Hussin F, Eshkoor SA, Rahmat A, Othman F, Akim A (2014) The centella asiatica juice effects on DNA damage, apoptosis and gene expression in hepatocellular carcinoma (HCC). BMC Complement Altern Med 14:32. https:\/\/doi.org\/10.1186\/1472-6882-14-32","journal-title":"BMC Complement Altern Med"},{"key":"733_CR33","doi-asserted-by":"crossref","first-page":"3519","DOI":"10.3892\/mmr.2017.6962","volume":"16","author":"X Jin","year":"2017","unstructured":"Jin X et al (2017) HO-1 alleviates cholesterol-induced oxidative stress through activation of Nrf2\/ERK and inhibition of PI3K\/AKT pathways in endothelial cells. Mol Med Rep 16:3519\u20133527","journal-title":"Mol Med Rep"},{"key":"733_CR34","first-page":"116","volume":"98","author":"Y-H Jing","year":"2013","unstructured":"Jing Y-H, Chen K-H, Kuo P-C, Pao C-C (2013) Chen J-KJN. Neurodegeneration in streptozotocin-induced diabetic rats is attenuated by treatment with resveratrol 98:116\u2013127","journal-title":"Neurodegeneration in streptozotocin-induced diabetic rats is attenuated by treatment with resveratrol"},{"key":"733_CR35","doi-asserted-by":"crossref","unstructured":"Kabir AU, Samad MB, D\u2019Costa NM, Akhter F, Ahmed A, Hannan JMAJBc, medicine a (2014) Anti-hyperglycemic activity of Centella asiatica is partly mediated by carbohydrase inhibition and glucose-fiber binding 14:31","DOI":"10.1186\/1472-6882-14-31"},{"key":"733_CR36","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1016\/j.foodchem.2004.12.004","volume":"94","author":"V Katalinic","year":"2006","unstructured":"Katalinic V, Milos M, Kulisic T, Jukic M (2006) Screening of 70 medicinal plant extracts for antioxidant capacity and total phenols. Food Chem 94:550\u2013557","journal-title":"Food Chem"},{"key":"733_CR37","doi-asserted-by":"publisher","first-page":"181643","DOI":"10.1155\/2015\/181643","volume":"2015","author":"KN Keane","year":"2015","unstructured":"Keane KN, Cruzat VF, Carlessi R, de Bittencourt PI, Newsholme P (2015) Molecular events linking oxidative stress and inflammation to insulin resistance and beta-cell dysfunction. Oxid Med Cell Longev 2015:181643. https:\/\/doi.org\/10.1155\/2015\/181643","journal-title":"Oxid Med Cell Longev"},{"key":"733_CR38","first-page":"59","volume":"10","author":"H Khan","year":"2020","unstructured":"Khan H, Ullah H, Aschner M, Cheang WS, Akkol EKJB (2020) Neuroprotective effects of quercetin in Alzheimer\u2019s. Disease 10:59","journal-title":"Disease"},{"key":"733_CR39","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1152\/physrev.00032.2015","volume":"96","author":"S Kullmann","year":"2016","unstructured":"Kullmann S, Heni M, Hallschmid M, Fritsche A, Preissl H, H\u00e4ring H-U (2016) Brain insulin resistance at the crossroads of metabolic and cognitive disorders in humans. Physiol Rev 96:1169\u20131209","journal-title":"Physiol Rev"},{"key":"733_CR40","doi-asserted-by":"publisher","first-page":"e0134476","DOI":"10.1371\/journal.pone.0134476","volume":"10","author":"C Lahmann","year":"2015","unstructured":"Lahmann C, Kramer HB, Ashcroft FM (2015) Systemic administration of glibenclamide fails to achieve therapeutic levels in the brain and cerebrospinal fluid of rodents. PLoS ONE 10:e0134476. https:\/\/doi.org\/10.1371\/journal.pone.0134476","journal-title":"PLoS ONE"},{"key":"733_CR41","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1007\/s11892-016-0782-y","volume":"16","author":"SS Leung","year":"2016","unstructured":"Leung SS, Forbes JM, Borg DJ (2016) Receptor for Advanced Glycation End Products (RAGE) in Type 1 Diabetes Pathogenesis. Curr Diabetes Rep 16:100. https:\/\/doi.org\/10.1007\/s11892-016-0782-y","journal-title":"Curr Diabetes Rep"},{"key":"733_CR42","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.tips.2013.03.007","volume":"34","author":"H Li","year":"2013","unstructured":"Li H, Horke S, F\u00f6rstermann U (2013) Oxidative stress in vascular disease and its pharmacological prevention. Trends Pharmacol Sci 34:313\u2013319","journal-title":"Trends Pharmacol Sci"},{"key":"733_CR43","doi-asserted-by":"publisher","DOI":"10.1177\/1535370217703360","author":"SY Loh","year":"2017","unstructured":"Loh SY, Giribabu N, Salleh N (2017) Effects of gonadectomy and testosterone treatment on aquaporin expression in the kidney of normotensive and hypertensive rats. Exp Biol Med. https:\/\/doi.org\/10.1177\/1535370217703360","journal-title":"Exp Biol Med"},{"key":"733_CR44","first-page":"4","volume":"23","author":"Y Lokanathan","year":"2016","unstructured":"Lokanathan Y, Omar N, Ahmad Puzi NN, Saim A, Hj Idrus R (2016) Recent updates in neuroprotective and neuroregenerative potential of centella asiatica. MJMS 23:4\u201314","journal-title":"MJMS"},{"key":"733_CR45","doi-asserted-by":"publisher","first-page":"6377","DOI":"10.3892\/mmr.2015.4219","volume":"12","author":"P Ma","year":"2015","unstructured":"Ma P et al (2015) Baicalin alleviates diabetesassociated cognitive deficits via modulation of mitogen-activated protein kinase signaling, brainderived neurotrophic factor and apoptosis. Mol Med Rep 12:6377\u20136383. https:\/\/doi.org\/10.3892\/mmr.2015.4219","journal-title":"Mol Med Rep"},{"key":"733_CR46","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1002\/9780470110171.ch14","volume":"1","author":"AC Maehly","year":"1954","unstructured":"Maehly AC, Chance B (1954) The assay of catalases and peroxidases. Methods Biochem Anal 1:357\u2013424","journal-title":"Methods Biochem Anal"},{"key":"733_CR47","doi-asserted-by":"publisher","first-page":"687","DOI":"10.1002\/med.21257","volume":"32","author":"S Magesh","year":"2012","unstructured":"Magesh S, Chen Y, Hu L (2012) Small molecule modulators of Keap1-Nrf2-ARE pathway as potential preventive and therapeutic agents(). Med Res Rev 32:687\u2013726. https:\/\/doi.org\/10.1002\/med.21257","journal-title":"Med Res Rev"},{"key":"733_CR48","first-page":"447","volume":"101","author":"B Masola","year":"2018","unstructured":"Masola B, Oguntibeju OO, Oyenihi ABJB (2018) Pharmacotherapy Centella asiatica ameliorates diabetes-induced stress in rat tissues via influences on antioxidants and inflammatory. Cytokines 101:447\u2013457","journal-title":"Cytokines"},{"key":"733_CR49","first-page":"95","volume":"24","author":"A Masoud","year":"2017","unstructured":"Masoud A et al (2017) Antioxidant effect of frankincense extract in the brain cortex of diabetic rats 24:95\u2013100","journal-title":"Antioxidant effect of frankincense extract in the brain cortex of diabetic rats"},{"key":"733_CR50","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1172\/JCI11916","volume":"107","author":"MP Mattson","year":"2001","unstructured":"Mattson MP, Camandola S (2001) NF-\u03baB in neuronal plasticity and neurodegenerative disorders. J Clin Investig 107:247\u2013254","journal-title":"J Clin Investig"},{"key":"733_CR51","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1016\/j.jep.2016.01.001","volume":"180","author":"Maulidiani","year":"2016","unstructured":"Maulidiani et al (2016) Metabolic alteration in obese diabetes rats upon treatment with Centella asiatica extract. J Ethnopharmacol 180:60\u201369. https:\/\/doi.org\/10.1016\/j.jep.2016.01.001","journal-title":"J Ethnopharmacol"},{"key":"733_CR52","doi-asserted-by":"crossref","first-page":"1447","DOI":"10.1007\/s00125-006-0221-8","volume":"49","author":"G Mijnhout","year":"2006","unstructured":"Mijnhout G et al (2006) Diabetic encephalopathy: a concept in need of a definition. Diabetologia 49:1447\u20131448","journal-title":"Diabetologia"},{"key":"733_CR53","doi-asserted-by":"crossref","first-page":"3170","DOI":"10.1016\/S0021-9258(19)45228-9","volume":"247","author":"HP Misra","year":"1972","unstructured":"Misra HP, Fridovich I (1972) The role of superoxide anion in the autoxidation of epinephrine and a simple assay for superoxide dismutase. J Biol Chem 247:3170\u20133175","journal-title":"J Biol Chem"},{"key":"733_CR54","doi-asserted-by":"crossref","unstructured":"Mohd Mokhtar H, Giribabu N, Kassim N, Muniandy S, Salleh N (2014) Testosterone decreases fluid and chloride secretions in the uterus of adult female rats via down-regulating cystic fibrosis transmembrane regulator (CFTR) expression and functional activity. J Steroid Biochem Mol Biol 144 Pt B:361\u2013372. doi:10.1016\/j.jsbmb.2014.08.007","DOI":"10.1016\/j.jsbmb.2014.08.007"},{"key":"733_CR55","doi-asserted-by":"crossref","unstructured":"Moreira PI, Cardoso SM, Pereira CM, Santos MS, Oliveira CR (2009) Mitochondria as a therapeutic target in Alzheimer's disease and diabetes CNS & Neurological Disorders-Drug Targets (Formerly Current Drug Targets-CNS & Neurological Disorders) 8:492\u2013511","DOI":"10.2174\/187152709789824651"},{"key":"733_CR56","doi-asserted-by":"crossref","unstructured":"Muriach M, Flores-Bellver M, Romero FJ, Barcia JM (2014) Diabetes and the brain: oxidative stress, inflammation, and autophagy Oxidative medicine and cellular longevity 2014","DOI":"10.1155\/2014\/102158"},{"key":"733_CR57","doi-asserted-by":"crossref","first-page":"27986","DOI":"10.1039\/C4RA13315C","volume":"5","author":"SB Nimse","year":"2015","unstructured":"Nimse SB, Pal D (2015) Free radicals, natural antioxidants, and their reaction mechanisms. RSC Adv 5:27986\u201328006","journal-title":"RSC Adv"},{"key":"733_CR58","unstructured":"Nugroho AE, Lindawati NY, Herlyanti K, Widyastuti L, Pramono S (2013) Anti-diabetic effect of a combination of andrographolide-enriched extract of Andrographis paniculata (Burm f.) Nees and asiaticoside-enriched extract of Centella asiatica L. in high fructose-fat fed rats. Indian J Exp Biol 51:1101\u20131108"},{"key":"733_CR59","unstructured":"OECD TNJOGftToC, Section (2001) 423: Acute Oral toxicity\u2013Acute Toxic Class Method 4"},{"key":"733_CR60","doi-asserted-by":"publisher","first-page":"a000034","DOI":"10.1101\/cshperspect.a000034","volume":"1","author":"A Oeckinghaus","year":"2009","unstructured":"Oeckinghaus A, Ghosh S (2009) The NF-\u03baB family of transcription factors and its regulation. Cold Spring Harbor Perspect Biol 1:a000034. https:\/\/doi.org\/10.1101\/cshperspect.a000034","journal-title":"Cold Spring Harbor Perspect Biol"},{"key":"733_CR61","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/0003-2697(79)90738-3","volume":"95","author":"H Ohkawa","year":"1979","unstructured":"Ohkawa H, Ohishi N, Yagi K (1979) Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal Biochem 95:351\u2013358","journal-title":"Anal Biochem"},{"key":"733_CR62","doi-asserted-by":"crossref","unstructured":"Ohnishi T, Suzuki T, Suzuki Y, Ozawa K (1982) A comparative study of plasma membrane Mg2+-ATPase activities in normal, regenerating and malignant cells. Biochim Biophys Acta (BBA) Biomemb 684:67\u201374","DOI":"10.1016\/0005-2736(82)90050-5"},{"key":"733_CR63","doi-asserted-by":"publisher","unstructured":"Portt L, Norman G, Clapp C, Greenwood M, Greenwood MT (2011) Anti-apoptosis and cell survival: a review. Biochim Biophys Acta (BBA) Mol Cell Res 1813:238\u2013259. https:\/\/doi.org\/10.1016\/j.bbamcr.2010.10.010","DOI":"10.1016\/j.bbamcr.2010.10.010"},{"key":"733_CR64","doi-asserted-by":"publisher","first-page":"1403","DOI":"10.1007\/s10072-012-1252-1","volume":"34","author":"A Prakash","year":"2013","unstructured":"Prakash A, Kumar A (2013) Mitoprotective effect of Centella asiatica against aluminum-induced neurotoxicity in rats: possible relevance to its anti-oxidant and anti-apoptosis mechanism. Clin Neurophysiol 34:1403\u20131409. https:\/\/doi.org\/10.1007\/s10072-012-1252-1","journal-title":"Clin Neurophysiol"},{"key":"733_CR65","unstructured":"Price TO, Farr SA, Niehoff ML, Ercal N, Morley JE, Shah GN (2015) Protective effect of topiramate on hyperglycemia-induced cerebral oxidative stress, pericyte loss and learning behavior in diabetic mice. Int Library Diabetes Metab 1"},{"key":"733_CR66","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1016\/j.lfs.2017.11.013","volume":"192","author":"F Prieto-Almeida","year":"2018","unstructured":"Prieto-Almeida F, Panveloski-Costa AC, Crunfli F, da Silva TS, Nunes MT, Torrao AS (2018) Thyroid hormone improves insulin signaling and reduces the activation of neurodegenerative pathway in the hippocampus of diabetic adult male rats. Life Sci 192:253\u2013258. https:\/\/doi.org\/10.1016\/j.lfs.2017.11.013","journal-title":"Life Sci"},{"key":"733_CR67","doi-asserted-by":"publisher","first-page":"1241","DOI":"10.1159\/000373947","volume":"35","author":"H Raza","year":"2015","unstructured":"Raza H, John A, Howarth FC (2015) Increased oxidative stress and mitochondrial dysfunction in zucker diabetic rat liver and brain. Cell Physiol Biochem 35:1241\u20131251. https:\/\/doi.org\/10.1159\/000373947","journal-title":"Cell Physiol Biochem"},{"key":"733_CR68","doi-asserted-by":"publisher","first-page":"570","DOI":"10.1016\/j.biopha.2016.12.044","volume":"86","author":"J Roslan","year":"2017","unstructured":"Roslan J, Giribabu N, Karim K, Salleh N (2017) Quercetin ameliorates oxidative stress, inflammation and apoptosis in the heart of streptozotocin-nicotinamide-induced adult male diabetic rats. Biomed Pharmacotherap 86:570\u2013582. https:\/\/doi.org\/10.1016\/j.biopha.2016.12.044","journal-title":"Biomed Pharmacotherap"},{"key":"733_CR69","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1126\/science.179.4073.588","volume":"179","author":"JT Rotruck","year":"1973","unstructured":"Rotruck JT, Pope AL, Ganther HE, Swanson AB, Hafeman DG, Hoekstra WG (1973) Selenium: biochemical role as a component of glutathione peroxidase. Science 179:588\u2013590","journal-title":"Science"},{"key":"733_CR70","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1093\/carcin\/10.6.1003","volume":"10","author":"RJ Ruch","year":"1989","unstructured":"Ruch RJ, Cheng S-J, Klaunig JE (1989) Prevention of cytotoxicity and inhibition of intercellular communication by antioxidant catechins isolated from Chinese green tea. Carcinogenesis 10:1003\u20131008","journal-title":"Carcinogenesis"},{"key":"733_CR71","doi-asserted-by":"publisher","first-page":"789613","DOI":"10.1155\/2013\/789613","volume":"2013","author":"S Saha","year":"2013","unstructured":"Saha S, Guria T, Singha T, Maity TK (2013) Evaluation of analgesic and anti-inflammatory activity of chloroform and methanol extracts of Centella asiatica Linn. ISRN Pharmacol 2013:789613. https:\/\/doi.org\/10.1155\/2013\/789613","journal-title":"ISRN Pharmacol"},{"key":"733_CR72","doi-asserted-by":"publisher","first-page":"920857","DOI":"10.1155\/2014\/920857","volume":"2014","author":"S Samarghandian","year":"2014","unstructured":"Samarghandian S, Azimi-Nezhad M, Samini F (2014) Ameliorative effect of saffron aqueous extract on hyperglycemia, hyperlipidemia, and oxidative stress on diabetic encephalopathy in streptozotocin induced experimental diabetes mellitus. BioMed Res Int 2014:920857. https:\/\/doi.org\/10.1155\/2014\/920857","journal-title":"BioMed Res Int"},{"key":"733_CR73","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1080\/1040869059096","volume":"45","author":"A Scalbert","year":"2005","unstructured":"Scalbert A, Manach C, Morand C, R\u00e9m\u00e9sy C, Jim\u00e9nez L (2005) Dietary polyphenols and the prevention of diseases. Crit Rev Food Sci Nutr 45:287\u2013306","journal-title":"Crit Rev Food Sci Nutr"},{"key":"733_CR74","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1097\/PSY.0000000000000207","volume":"77","author":"ER Seaquist","year":"2015","unstructured":"Seaquist ER (2015) The impact of diabetes on cerebral structure and function. Psychosom Med 77:616\u2013621","journal-title":"Psychosom Med"},{"key":"733_CR75","doi-asserted-by":"crossref","unstructured":"Shahzad H, Giribabu N, Karim K, Kassim NM, Muniandy S, Salleh N (2017) Combinatorial effects of quercetin and sex-steroids on fluid and electrolytes' (Na+, Cl-, HCO3-) secretory mechanisms in the uterus of ovariectomised female Sprague-Dawley rats 12:e0172765 doi:10.1371\/journal.pone.0172765","DOI":"10.1371\/journal.pone.0172765"},{"key":"733_CR76","doi-asserted-by":"crossref","first-page":"1583","DOI":"10.3390\/molecules24081583","volume":"24","author":"A Singh","year":"2019","unstructured":"Singh A, Kukreti R, Saso L, Kukreti S (2019) Oxidative stress: A key modulator in neurodegenerative diseases. Molecules 24:1583","journal-title":"Molecules"},{"key":"733_CR77","unstructured":"Singh G (2015) Experimental Study on Immunity Potentiation Effect of Mandukaparni (Hydrocotyle asiatica) Journal of Ayurveda Physcians and Surgeons 2:2\u20138"},{"key":"733_CR78","unstructured":"Singh S, Gautam A, Sharma A, Batra A (2010) Centella asiatica (L.): a plant with immense medicinal potential but threatened International Journal of Pharmaceutical Sciences Review and Research 4"},{"key":"733_CR79","doi-asserted-by":"publisher","first-page":"1","DOI":"10.4196\/kjpp.2014.18.1.1","volume":"18","author":"VP Singh","year":"2014","unstructured":"Singh VP, Bali A, Singh N, Jaggi AS (2014) Advanced glycation end products and diabetic complications. Korean J Physiol Pharmacol 18:1\u201314. https:\/\/doi.org\/10.4196\/kjpp.2014.18.1.1","journal-title":"Korean J Physiol Pharmacol"},{"key":"733_CR80","doi-asserted-by":"publisher","first-page":"101059","DOI":"10.1016\/j.redox.2018.11.017","volume":"21","author":"F Sivandzade","year":"2019","unstructured":"Sivandzade F, Prasad S, Bhalerao A, Cucullo L (2019) NRF2 and NF-\u049bB interplay in cerebrovascular and neurodegenerative disorders: Molecular mechanisms and possible therapeutic approaches. Redox Biol 21:101059\u2013101059. https:\/\/doi.org\/10.1016\/j.redox.2018.11.017","journal-title":"Redox Biol"},{"key":"733_CR81","doi-asserted-by":"publisher","first-page":"1914","DOI":"10.1016\/j.neurobiolaging.2015.02.020","volume":"36","author":"AR Vasconcelos","year":"2015","unstructured":"Vasconcelos AR et al (2015) Effects of intermittent fasting on age-related changes on Na, K-ATPase activity and oxidative status induced by lipopolysaccharide in rat hippocampus. Neurobiol Aging 36:1914\u20131923. https:\/\/doi.org\/10.1016\/j.neurobiolaging.2015.02.020","journal-title":"Neurobiol Aging"},{"key":"733_CR82","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1046\/j.1440-1681.2003.03842.x","volume":"30","author":"MH Veerendra Kumar","year":"2003","unstructured":"Veerendra Kumar MH, Gupta YK (2003) Effect of Centella asiatica on cognition and oxidative stress in an intracerebroventricular streptozotocin model of Alzheimer's disease in rats. Clin Exp Pharmacol Physiol 30:336\u2013342","journal-title":"Clin Exp Pharmacol Physiol"},{"key":"733_CR83","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1369\/0022155418772798","volume":"66","author":"A Vetuschi","year":"2018","unstructured":"Vetuschi A et al (2018) Immunolocalization of advanced glycation end products, mitogen activated protein kinases, and transforming growth factor-\u03b2\/Smads in pelvic organ prolapse. J Histochem Cytochem 66:673\u2013686","journal-title":"J Histochem Cytochem"},{"key":"733_CR84","doi-asserted-by":"crossref","first-page":"82","DOI":"10.4103\/0253-7613.64504","volume":"42","author":"G Visweswari","year":"2010","unstructured":"Visweswari G, Prasad KS, Lokanatha V, Rajendra W (2010) The antiepileptic effect of Centella asiatica on the activities of Na+\/K+, Mg2+ and Ca2+-ATPases in rat brain during pentylenetetrazol-induced epilepsy. Indian J Pharmacol 42:82","journal-title":"Indian J Pharmacol"},{"key":"733_CR85","first-page":"440","volume":"2","author":"K Vohra","year":"2011","unstructured":"Vohra K, Pal G, Gupta VK, Singh S, Bansal Y (2011) An Insight on Centella asiatica Linn: a review. Recent Res Pharmacol 2:440\u2013463","journal-title":"Recent Res Pharmacol"},{"key":"733_CR86","first-page":"5374","volume":"23","author":"Q Wang","year":"2019","unstructured":"Wang Q, Lu L (2019) Zhou HJErfm, sciences p. Relationship between the MAPK\/ERK pathway and neurocyte apoptosis after cerebral infarction in rats 23:5374\u20135381","journal-title":"Relationship between the MAPK\/ERK pathway and neurocyte apoptosis after cerebral infarction in rats"},{"key":"733_CR87","first-page":"128","volume":"854","author":"Z Xi","year":"2019","unstructured":"Xi Z et al (2019) Protocatechuic acid exerts protective effects via suppression of the P38\/JNK-NF-\u03baB signalling pathway in an experimental mouse model of intracerebral. Haemorrhage 854:128\u2013138","journal-title":"Haemorrhage"},{"key":"733_CR88","first-page":"1189","volume":"41","author":"Z Xiang","year":"2008","unstructured":"Xiang Z, Ning Z (2008) Scavenging and antioxidant properties of compound derived from chlorogenic acid in South-China honeysuckle LWT-Food. Sci Technol 41:1189\u20131203","journal-title":"Sci Technol"},{"key":"733_CR89","doi-asserted-by":"publisher","first-page":"101","DOI":"10.4161\/oxim.3.2.4","volume":"3","author":"S-I Yamagishi","year":"2010","unstructured":"Yamagishi S-I, Matsui T (2010) Advanced glycation end products, oxidative stress and diabetic nephropathy Oxidative. Med Cell Longevity 3:101\u2013108. https:\/\/doi.org\/10.4161\/oxim.3.2.4","journal-title":"Med Cell Longevity"},{"key":"733_CR90","doi-asserted-by":"crossref","unstructured":"Yamagishi S-I, Matsui T (2018) Role of Hyperglycemia-Induced Advanced Glycation End Product (AGE) Accumulation in Atherosclerosis Annals of vascular diseases:ra. 18\u201300070","DOI":"10.3400\/avd.ra.18-00070"},{"key":"733_CR91","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1016\/j.bbr.2015.06.024","volume":"292","author":"Z Yin","year":"2015","unstructured":"Yin Z et al (2015) Asiaticoside attenuates diabetes-induced cognition deficits by regulating PI3K\/Akt\/NF-\u03baB pathway. Behav Brain Res 292:288\u2013299","journal-title":"Behav Brain Res"},{"key":"733_CR92","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/S0308-8146(98)00102-2","volume":"64","author":"J Zhishen","year":"1999","unstructured":"Zhishen J, Mengcheng T, Jianming W (1999) The determination of flavonoid contents in mulberry and their scavenging effects on superoxide radicals. Food Chem 64:555\u2013559","journal-title":"Food Chem"}],"container-title":["Inflammopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10787-020-00733-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10787-020-00733-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10787-020-00733-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,8]],"date-time":"2024-08-08T11:47:55Z","timestamp":1723117675000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10787-020-00733-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6,25]]},"references-count":92,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2020,12]]}},"alternative-id":["733"],"URL":"https:\/\/doi.org\/10.1007\/s10787-020-00733-3","relation":{},"ISSN":["0925-4692","1568-5608"],"issn-type":[{"value":"0925-4692","type":"print"},{"value":"1568-5608","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,6,25]]},"assertion":[{"value":"23 October 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 June 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 June 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"Authors wish to confirm that there was no conflict of interest associated with this publication and there has been no significant financial support for this work that could influence its outcome.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}