{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T17:28:03Z","timestamp":1793381283604,"version":"4.5.0"},"reference-count":39,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81960677"],"award-info":[{"award-number":["81960677"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81660689"],"award-info":[{"award-number":["81660689"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Science and Technology Planning Projects from the Science and Technology Department of Jilin Province","award":["20180414048GH"],"award-info":[{"award-number":["20180414048GH"]}]},{"name":"Science and Technology Planning Projects from the Science and Technology Department of Jilin Province","award":["20180201065YY"],"award-info":[{"award-number":["20180201065YY"]}]},{"name":"Science and Technology Planning Projects from the Science and Technology Department of Jilin Province","award":["20180519010JH"],"award-info":[{"award-number":["20180519010JH"]}]},{"name":"Science and Technology Planning Project of the Jilin Provincial Education Department","award":["JJKH20191155KJ"],"award-info":[{"award-number":["JJKH20191155KJ"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Inflammopharmacol"],"published-print":{"date-parts":[[2020,12]]},"DOI":"10.1007\/s10787-020-00758-8","type":"journal-article","created":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T19:03:18Z","timestamp":1601578998000},"page":"1481-1493","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":41,"title":["Management of Gout-associated MSU crystals-induced NLRP3 inflammasome activation by procyanidin B2: targeting IL-1\u03b2 and Cathepsin B in macrophages"],"prefix":"10.1007","volume":"28","author":[{"given":"Chun-Ying","family":"Qiao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Shang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zi-Ying","family":"Zhan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huan","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong-Ce","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing-Ya","family":"Jiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rong-Hui","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi-Hong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mei-Hua","family":"Piao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan-Ling","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6221-4309","authenticated-orcid":false,"given":"Ji-Xing","family":"Nan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-Hua","family":"Lian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,10,1]]},"reference":[{"key":"758_CR1","doi-asserted-by":"publisher","first-page":"1111","DOI":"10.1089\/ars.2014.5994","volume":"22","author":"JM Abais","year":"2015","unstructured":"Abais JM, Xia M, Zhang Y, Boini KM, Li PL (2015) Redox regulation of NLRP3 inflammasomes: ROS as trigger or effector? Antioxid Redox Signal 22:1111\u20131129. https:\/\/doi.org\/10.1089\/ars.2014.5994","journal-title":"Antioxid Redox Signal"},{"key":"758_CR2","doi-asserted-by":"publisher","first-page":"1427","DOI":"10.3389\/fimmu.2018.01427","volume":"9","author":"EP Amaral","year":"2018","unstructured":"Amaral EP et al (2018) Lysosomal cathepsin release is required for NLRP3-inflammasome activation by Mycobacterium tuberculosis in infected macrophages. Front Immunol 9:1427","journal-title":"Front Immunol"},{"key":"758_CR3","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1016\/j.yexcr.2017.11.015","volume":"362","author":"H Bai","year":"2018","unstructured":"Bai H, Yang B, Yu W, Xiao Y, Yu D, Zhang Q (2018) Cathepsin B links oxidative stress to the activation of NLRP3 inflammasome. Exp Cell Res 362:180\u2013187. https:\/\/doi.org\/10.1016\/j.yexcr.2017.11.015","journal-title":"Exp Cell Res"},{"key":"758_CR4","doi-asserted-by":"publisher","first-page":"167","DOI":"10.3389\/fcell.2020.00167","volume":"8","author":"A Chevriaux","year":"2020","unstructured":"Chevriaux A et al (2020) Cathepsin B is required for NLRP3 inflammasome activation in macrophages, through NLRP3 interaction. Front Cell Dev Biol 8:167. https:\/\/doi.org\/10.3389\/fcell.2020.00167","journal-title":"Front Cell Dev Biol"},{"key":"758_CR5","doi-asserted-by":"publisher","first-page":"487","DOI":"10.1016\/j.bbrc.2020.05.084","volume":"530","author":"J-P Chuang","year":"2020","unstructured":"Chuang J-P, Kao C-Y, Lee J-C, Ling P, Maa M-C, Leu T-H (2020) EPS8 regulates an NLRP3 inflammasome-independent caspase-1 activation pathway in monosodium urate crystal-treated RAW264.7 macrophages. Biochem Biophys Res Commun 530:487\u2013493. https:\/\/doi.org\/10.1016\/j.bbrc.2020.05.084","journal-title":"Biochem Biophys Res Commun"},{"key":"758_CR6","doi-asserted-by":"publisher","first-page":"1465","DOI":"10.1016\/j.clinthera.2014.07.017","volume":"36","author":"N Dalbeth","year":"2014","unstructured":"Dalbeth N, Lauterio TJ, Wolfe HR (2014) Mechanism of action of colchicine in the treatment of gout. Clin Ther 36:1465\u20131479. https:\/\/doi.org\/10.1016\/j.clinthera.2014.07.017","journal-title":"Clin Ther"},{"key":"758_CR7","doi-asserted-by":"publisher","first-page":"4312","DOI":"10.1073\/pnas.0707370105","volume":"105","author":"SL Fink","year":"2008","unstructured":"Fink SL, Bergsbaken T, Cookson BT (2008) Anthrax lethal toxin and Salmonella elicit the common cell death pathway of caspase-1-dependent pyroptosis via distinct mechanisms. Proc Natl Acad Sci USA 105:4312\u20134317. https:\/\/doi.org\/10.1073\/pnas.0707370105","journal-title":"Proc Natl Acad Sci USA"},{"key":"758_CR8","doi-asserted-by":"publisher","first-page":"622","DOI":"10.1093\/rheumatology\/keq358","volume":"50","author":"T Funck-Brentano","year":"2011","unstructured":"Funck-Brentano T, Salliot C, Leboime A, Zafrani L, Servais A, Larousserie F, Dougados M (2011) First observation of the efficacy of IL-1ra to treat tophaceous gout of the lumbar spine. Rheumatology (Oxford) 50:622\u2013624. https:\/\/doi.org\/10.1093\/rheumatology\/keq358","journal-title":"Rheumatology (Oxford)"},{"key":"758_CR9","doi-asserted-by":"publisher","first-page":"1003","DOI":"10.1016\/j.immuni.2013.11.010","volume":"39","author":"C Garlanda","year":"2013","unstructured":"Garlanda C, Dinarello CA, Mantovani A (2013) The interleukin-1 family: back to the future. Immunity 39:1003\u20131018. https:\/\/doi.org\/10.1016\/j.immuni.2013.11.010","journal-title":"Immunity"},{"key":"758_CR10","doi-asserted-by":"publisher","first-page":"4162","DOI":"10.1096\/fj.14-267393","volume":"29","author":"T Gicquel","year":"2015","unstructured":"Gicquel T et al (2015) IL-1\u03b2 production is dependent on the activation of purinergic receptors and NLRP3 pathway in human macrophages. FASEB J 29:4162\u20134173. https:\/\/doi.org\/10.1096\/fj.14-267393","journal-title":"FASEB J"},{"key":"758_CR11","doi-asserted-by":"publisher","first-page":"2077","DOI":"10.1016\/j.celrep.2017.02.004","volume":"18","author":"EL Goldberg","year":"2017","unstructured":"Goldberg EL et al (2017) beta-Hydroxybutyrate deactivates neutrophil NLRP3 inflammasome to relieve gout flares. Cell Rep 18:2077\u20132087. https:\/\/doi.org\/10.1016\/j.celrep.2017.02.004","journal-title":"Cell Rep"},{"key":"758_CR12","doi-asserted-by":"publisher","first-page":"e22366","DOI":"10.1002\/jbt.22366","volume":"33","author":"X Guo","year":"2019","unstructured":"Guo X, Chen Y, Li Q, Yang X, Zhao G, Peng Y, Zheng J (2019) Studies on hepatotoxicity and toxicokinetics of colchicine. J Biochem Mol Toxicol 33:e22366. https:\/\/doi.org\/10.1002\/jbt.22366","journal-title":"J Biochem Mol Toxicol"},{"key":"758_CR13","doi-asserted-by":"publisher","first-page":"208","DOI":"10.1097\/BOR.0000000000000361","volume":"29","author":"M Hahn","year":"2017","unstructured":"Hahn M, Frey S, Hueber AJ (2017) The novel interleukin-1 cytokine family members in inflammatory diseases. Curr Opin Rheumatol 29:208\u2013213. https:\/\/doi.org\/10.1097\/BOR.0000000000000361","journal-title":"Curr Opin Rheumatol"},{"key":"758_CR14","doi-asserted-by":"publisher","first-page":"1752","DOI":"10.1172\/JCI94584","volume":"128","author":"CJ Hall","year":"2018","unstructured":"Hall CJ et al (2018) Blocking fatty acid-fueled mROS production within macrophages alleviates acute gouty inflammation. J Clin Investig 128:1752\u20131771. https:\/\/doi.org\/10.1172\/JCI94584","journal-title":"J Clin Investig"},{"key":"758_CR15","doi-asserted-by":"publisher","first-page":"10","DOI":"10.3389\/fphar.2017.00010","volume":"8","author":"HJ Khameneh","year":"2017","unstructured":"Khameneh HJ et al (2017) C5a regulates IL-1beta production and leukocyte recruitment in a murine model of monosodium urate crystal-induced peritonitis. Front Pharmacol 8:10. https:\/\/doi.org\/10.3389\/fphar.2017.00010","journal-title":"Front Pharmacol"},{"key":"758_CR16","doi-asserted-by":"publisher","first-page":"38622","DOI":"10.1038\/srep38622","volume":"6","author":"HE Lee","year":"2016","unstructured":"Lee HE et al (2016) Targeting ASC in NLRP3 inflammasome by caffeic acid phenethyl ester: a novel strategy to treat acute gout. Sci Rep 6:38622. https:\/\/doi.org\/10.1038\/srep38622","journal-title":"Sci Rep"},{"key":"758_CR17","doi-asserted-by":"publisher","DOI":"10.3390\/molecules24112138","author":"HE Lee","year":"2019","unstructured":"Lee HE, Yang G, Park YB, Kang HC, Cho YY, Lee HS, Lee JY (2019) Epigallocatechin-3-Gallate prevents acute gout by suppressing NLRP3 inflammasome activation and mitochondrial DNA synthesis. Molecules. https:\/\/doi.org\/10.3390\/molecules24112138","journal-title":"Molecules"},{"key":"758_CR18","doi-asserted-by":"publisher","first-page":"30094","DOI":"10.1074\/jbc.M113.494286","volume":"288","author":"S Li","year":"2013","unstructured":"Li S et al (2013) Cathepsin B contributes to autophagy-related 7 (Atg7)-induced nod-like receptor 3 (NLRP3)-dependent proinflammatory response and aggravates lipotoxicity in rat insulinoma cell line. J Biol Chem 288:30094\u201330104. https:\/\/doi.org\/10.1074\/jbc.M113.494286","journal-title":"J Biol Chem"},{"key":"758_CR19","doi-asserted-by":"publisher","first-page":"1451","DOI":"10.1111\/bph.14145","volume":"175","author":"X Li","year":"2018","unstructured":"Li X et al (2018) Liver kinase B1\/AMP-activated protein kinase-mediated regulation by gentiopicroside ameliorates P2X7 receptor-dependent alcoholic hepatosteatosis. Br J Pharmacol 175:1451\u20131470. https:\/\/doi.org\/10.1111\/bph.14145","journal-title":"Br J Pharmacol"},{"key":"758_CR20","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1186\/s12974-017-0849-y","volume":"14","author":"HJ Liu","year":"2017","unstructured":"Liu HJ et al (2017) Grape seed-derived procyanidins alleviate gout pain via NLRP3 inflammasome suppression. J Neuroinflamm. 14:74. https:\/\/doi.org\/10.1186\/s12974-017-0849-y","journal-title":"J Neuroinflamm."},{"key":"758_CR21","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1016\/j.molimm.2018.09.010","volume":"103","author":"Q Liu","year":"2018","unstructured":"Liu Q, Zhang D, Hu D, Zhou X, Zhou Y (2018) The role of mitochondria in NLRP3 inflammasome activation. Mol Immunol 103:115\u2013124. https:\/\/doi.org\/10.1016\/j.molimm.2018.09.010","journal-title":"Mol Immunol"},{"key":"758_CR22","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1002\/JLB.3HI0518-193R","volume":"105","author":"Y Liu","year":"2019","unstructured":"Liu Y et al (2019) Frontline science: reprogramming COX-2, 5-LOX, and CYP4A-mediated arachidonic acid metabolism in macrophages by salidroside alleviates gouty arthritis. J Leukoc Biol 105:11\u201324. https:\/\/doi.org\/10.1002\/JLB.3HI0518-193R","journal-title":"J Leukoc Biol"},{"key":"758_CR23","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1186\/s13075-018-1664-2","volume":"20","author":"C Marchetti","year":"2018","unstructured":"Marchetti C et al (2018) NLRP3 inflammasome inhibitor OLT1177 suppresses joint inflammation in murine models of acute arthritis. Arthritis Res Ther 20:169. https:\/\/doi.org\/10.1186\/s13075-018-1664-2","journal-title":"Arthritis Res Ther"},{"key":"758_CR24","doi-asserted-by":"publisher","first-page":"262","DOI":"10.1002\/mnfr.201400370","volume":"59","author":"N Martinez-Micaelo","year":"2015","unstructured":"Martinez-Micaelo N, Gonzalez-Abuin N, Pinent M, Ardevol A, Blay M (2015) Procyanidin B2 inhibits inflammasome-mediated IL-1beta production in lipopolysaccharide-stimulated macrophages. Mol Nutr Food Res 59:262\u2013269. https:\/\/doi.org\/10.1002\/mnfr.201400370","journal-title":"Mol Nutr Food Res"},{"key":"758_CR25","doi-asserted-by":"publisher","first-page":"454","DOI":"10.1038\/ni.2550","volume":"14","author":"T Misawa","year":"2013","unstructured":"Misawa T, Takahama M, Kozaki T, Lee H, Zou J, Saitoh T, Akira S (2013) Microtubule-driven spatial arrangement of mitochondria promotes activation of the NLRP3 inflammasome. Nat Immunol 14:454\u2013460. https:\/\/doi.org\/10.1038\/ni.2550","journal-title":"Nat Immunol"},{"key":"758_CR26","doi-asserted-by":"publisher","first-page":"725","DOI":"10.1038\/nrrheum.2015.125","volume":"11","author":"E Pascual","year":"2015","unstructured":"Pascual E, Addadi L, Andres M, Sivera F (2015) Mechanisms of crystal formation in gout-a structural approach. Nat Rev Rheumatol 11:725\u2013730. https:\/\/doi.org\/10.1038\/nrrheum.2015.125","journal-title":"Nat Rev Rheumatol"},{"key":"758_CR27","doi-asserted-by":"publisher","first-page":"36","DOI":"10.3389\/fimmu.2017.00036","volume":"8","author":"C Pellegrini","year":"2017","unstructured":"Pellegrini C, Antonioli L, Lopez-Castejon G, Blandizzi C, Fornai M (2017) Canonical and non-canonical activation of NLRP3 inflammasome at the crossroad between immune tolerance and intestinal inflammation. Front Immunol 8:36. https:\/\/doi.org\/10.3389\/fimmu.2017.00036","journal-title":"Front Immunol"},{"key":"758_CR28","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1007\/s00296-013-2856-3","volume":"34","author":"YF Qing","year":"2014","unstructured":"Qing YF, Zhang QB, Zhou JG, Jiang L (2014) Changes in toll-like receptor (TLR)4-NFkappaB-IL1beta signaling in male gout patients might be involved in the pathogenesis of primary gouty arthritis. Rheumatol Int 34:213\u2013220. https:\/\/doi.org\/10.1007\/s00296-013-2856-3","journal-title":"Rheumatol Int"},{"key":"758_CR29","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1038\/nrrheum.2012.143","volume":"9","author":"KL Rock","year":"2013","unstructured":"Rock KL, Kataoka H, Lai JJ (2013) Uric acid as a danger signal in gout and its comorbidities Nature reviews. Rheumatology 9:13\u201323. https:\/\/doi.org\/10.1038\/nrrheum.2012.143","journal-title":"Rheumatology"},{"key":"758_CR30","doi-asserted-by":"publisher","first-page":"1041","DOI":"10.1016\/j.freeradbiomed.2005.05.024","volume":"39","author":"K Sakano","year":"2005","unstructured":"Sakano K, Mizutani M, Murata M, Oikawa S, Hiraku Y, Kawanishi S (2005) Procyanidin B2 has anti- and pro-oxidant effects on metal-mediated DNA damage. Free Radic Biol Med 39:1041\u20131049. https:\/\/doi.org\/10.1016\/j.freeradbiomed.2005.05.024","journal-title":"Free Radic Biol Med"},{"key":"758_CR31","doi-asserted-by":"crossref","unstructured":"Shi Y, Mucsi AD, Ng G (2020) Yan Shi.pdf","DOI":"10.1287\/aafc9f12-eebe-4c26-b253-68f31c46a76e"},{"key":"758_CR32","doi-asserted-by":"publisher","first-page":"639","DOI":"10.1038\/nrrheum.2017.155","volume":"13","author":"AK So","year":"2017","unstructured":"So AK, Martinon F (2017) Inflammation in gout: mechanisms and therapeutic targets. Nat Rev Rheumatol 13:639\u2013647. https:\/\/doi.org\/10.1038\/nrrheum.2017.155","journal-title":"Nat Rev Rheumatol"},{"key":"758_CR33","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1016\/j.freeradbiomed.2018.08.024","volume":"126","author":"H Su","year":"2018","unstructured":"Su H, Li Y, Hu D, Xie L, Ke H, Zheng X, Chen W (2018) Procyanidin B2 ameliorates free fatty acids-induced hepatic steatosis through regulating TFEB-mediated lysosomal pathway and redox state. Free Radic Biol Med 126:269\u2013286. https:\/\/doi.org\/10.1016\/j.freeradbiomed.2018.08.024","journal-title":"Free Radic Biol Med"},{"key":"758_CR34","doi-asserted-by":"publisher","first-page":"4935","DOI":"10.1016\/j.bmcl.2013.06.061","volume":"23","author":"M Suda","year":"2013","unstructured":"Suda M et al (2013) Syntheses of procyanidin B2 and B3 gallate derivatives using equimolar condensation mediated by Yb(OTf)3 and their antitumor activities. Bioorg Med Chem Lett 23:4935\u20134939. https:\/\/doi.org\/10.1016\/j.bmcl.2013.06.061","journal-title":"Bioorg Med Chem Lett"},{"key":"758_CR35","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD006190.pub2","author":"I van Echteld","year":"2014","unstructured":"van Echteld I, Wechalekar MD, Schlesinger N, Buchbinder R, Aletaha D (2014) Colchicine for acute gout. Cochrane Database Syst Rev. https:\/\/doi.org\/10.1002\/14651858.CD006190.pub2","journal-title":"Cochrane Database Syst Rev"},{"key":"758_CR36","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2019\/2969364","volume":"2019","author":"ZC Wu","year":"2019","unstructured":"Wu ZC, Xue Q, Zhao ZL, Zhou PJ, Zhou Q, Zhang Z, Deng JP, Yang K, Fan K, Fan H, Wang YF, Wang ZP (2019) Suppressive effect of Huzhentongfeng on experimental gouty arthritis: an in vivo and in vitro study. Evid Based Complement Altern Med 2019:1\u201315. https:\/\/doi.org\/10.1155\/2019\/2969364","journal-title":"Evid Based Complement Altern Med"},{"key":"758_CR37","doi-asserted-by":"publisher","first-page":"599","DOI":"10.1016\/j.bcp.2014.10.001","volume":"92","author":"H Yang","year":"2014","unstructured":"Yang H, Xiao L, Yuan Y, Luo X, Jiang M, Ni J, Wang N (2014) Procyanidin B2 inhibits NLRP3 inflammasome activation in human vascular endothelial cells. Biochem Pharmacol 92:599\u2013606. https:\/\/doi.org\/10.1016\/j.bcp.2014.10.001","journal-title":"Biochem Pharmacol"},{"key":"758_CR38","doi-asserted-by":"publisher","first-page":"1899","DOI":"10.4172\/Neuropsychiatry.1000533","volume":"8","author":"Q Zhang","year":"2018","unstructured":"Zhang Q, Duan J, Yang B, Yu D, Liu L, Bai H (2018) Cathepsin B regulates the activation of NLRP3 inflammasome by calcium signaling. Neuropsychiatry 8:1899\u20131912. https:\/\/doi.org\/10.4172\/Neuropsychiatry.1000533","journal-title":"Neuropsychiatry"},{"key":"758_CR39","first-page":"736","volume":"52","author":"M Zurek","year":"2006","unstructured":"Zurek M (2006) Pathogenesis, diagnostics and therapy of gout. Vnitr Lek 52:736\u2013741","journal-title":"Vnitr Lek"}],"container-title":["Inflammopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10787-020-00758-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10787-020-00758-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10787-020-00758-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T02:06:51Z","timestamp":1633054011000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10787-020-00758-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10,1]]},"references-count":39,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2020,12]]}},"alternative-id":["758"],"URL":"https:\/\/doi.org\/10.1007\/s10787-020-00758-8","relation":{},"ISSN":["0925-4692","1568-5608"],"issn-type":[{"value":"0925-4692","type":"print"},{"value":"1568-5608","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,10,1]]},"assertion":[{"value":"29 June 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 September 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 October 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors have declared no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}