{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T11:00:41Z","timestamp":1768993241117,"version":"3.49.0"},"reference-count":43,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Inflammopharmacol"],"published-print":{"date-parts":[[2021,6]]},"DOI":"10.1007\/s10787-021-00834-7","type":"journal-article","created":{"date-parts":[[2021,6,4]],"date-time":"2021-06-04T07:03:26Z","timestamp":1622790206000},"page":"721-733","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Ketoconazole-p aminobenzoic cocrystal, an improved antimycotic drug formulation, does not induce skin sensitization on the skin of BALBc mice"],"prefix":"10.1007","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0968-4026","authenticated-orcid":false,"given":"Sorina","family":"Danescu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7447-4925","authenticated-orcid":false,"given":"Gabriela Adriana","family":"Filip","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8459-8657","authenticated-orcid":false,"given":"Remus","family":"Moldovan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3034-3659","authenticated-orcid":false,"given":"Diana","family":"Olteanu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9596-2899","authenticated-orcid":false,"given":"Andras","family":"Nagy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6441-3793","authenticated-orcid":false,"given":"Xenia","family":"Filip","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1987-9735","authenticated-orcid":false,"given":"Flavia","family":"Martin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1039-0543","authenticated-orcid":false,"given":"Irina","family":"Kacso","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9554-2982","authenticated-orcid":false,"given":"Ioana","family":"Baldea","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,6,4]]},"reference":[{"key":"834_CR1","unstructured":"Agilent (2010) CrysAlis PRO Agilent Technologies. Oxfordshire, England https:\/\/www.agilent.com\/cs\/library\/usermanuals\/Public\/CrysAlis_Pro_User_Manual.pdf. Accessed 25 January 2021."},{"key":"834_CR2","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1093\/toxsci\/kft084","volume":"134","author":"ZE Ali","year":"2013","unstructured":"Ali ZE, Gerbeix C, Hemon P, Esser PR, Martin SF, Pallardy M, Kerdine-R\u00f6mer S (2013) Allergic skin inflammation induced by chemical sensitizers is controlled by the transcription factor Nrf2. Toxicol Sci 134:39\u201348","journal-title":"Toxicol Sci"},{"key":"834_CR3","first-page":"603","volume-title":"Sunscreens","author":"JK Aronson","year":"2016","unstructured":"Aronson JK (2016) Meyler\u2019s side effects of drugs. In: Aronson JK (ed) Sunscreens, 16th edn. Elsevier, Waltham, MA, pp 603\u2013604","edition":"16"},{"key":"834_CR4","doi-asserted-by":"publisher","first-page":"760","DOI":"10.1080\/09546634.2019.1573309","volume":"30","author":"FD Choi","year":"2019","unstructured":"Choi FD, Juhasz MLW, Mesinkovska NA (2019) Topical ketoconazole: a systematic review of current dermatological applications and future developments. J Dermatolog Treat 30:760\u2013771","journal-title":"J Dermatolog Treat"},{"key":"834_CR5","doi-asserted-by":"publisher","first-page":"e101892","DOI":"10.1371\/journal.pone.0101892","volume":"9","author":"ME Crisan","year":"2014","unstructured":"Crisan ME, Bourosh P, Maffei ME, Forni A, Pieraccini S, Sironi M, Chumakov YM (2014) Synthesis, crystal structure and biological activity of 2-hydroxyethylammonium salt of p-aminobenzoic acid. PLoS ONE 9:e101892. https:\/\/doi.org\/10.1371\/journal.pone.0101892","journal-title":"PLoS ONE"},{"key":"834_CR6","doi-asserted-by":"publisher","first-page":"767","DOI":"10.1016\/j.colsurfb.2014.08.018","volume":"122","author":"L David","year":"2014","unstructured":"David L, Moldovan B, Vulcu A et al (2014) Green synthesis, characterization and anti-inflammatory activity of silver nanoparticles using European black elderberry fruits extract. Colloids Surf B Biointerfaces 122:767\u2013777","journal-title":"Colloids Surf B Biointerfaces"},{"key":"834_CR7","doi-asserted-by":"publisher","first-page":"296","DOI":"10.1016\/j.msec.2017.04.089","volume":"78","author":"P Deng","year":"2017","unstructured":"Deng P, Teng F, Zhou F, Song Z, Meng N, Liu N, Feng R (2017) Y-shaped methoxy poly (ethylene glycol)-block-poly (epsilon-caprolactone)-based micelles for skin delivery of ketoconazole: in vitro study and in vivo evaluation. Mater Sci Eng C Mater Biol Appl 78:296\u2013304","journal-title":"Mater Sci Eng C Mater Biol Appl"},{"key":"834_CR8","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1107\/S0021889808042726","volume":"42","author":"OV Dolomanov","year":"2009","unstructured":"Dolomanov OV, Bourhis LJ, Gildea RJ, Howard JAK, Puschmann H (2009) OLEX2: a complete structure solution, refinement and analysis program. J Appl Crystallogr 42:339\u2013341","journal-title":"J Appl Crystallogr"},{"key":"834_CR9","doi-asserted-by":"publisher","first-page":"242","DOI":"10.1016\/0272-0590(90)90051-k","volume":"15","author":"BJ Dunn","year":"1990","unstructured":"Dunn BJ, Rusch GM, Siglin JC, Blaszcak DL (1990) Variability of a mouse ear swelling test (MEST) in predicting weak and moderate contact sensitization. Fundam Appl Toxicol 15:242\u2013248. https:\/\/doi.org\/10.1016\/0272-0590(90)90051-k","journal-title":"Fundam Appl Toxicol"},{"key":"834_CR10","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1016\/j.taap.2010.03.009","volume":"245","author":"R Emter","year":"2010","unstructured":"Emter R, Ellis G, Natsch A (2010) Performance of a novel keratinocyte-based reporter cell line to screen skin sensitizers in vitro. Toxicol Appl Pharmacol 245:281\u2013290","journal-title":"Toxicol Appl Pharmacol"},{"key":"834_CR11","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1016\/0041-008X(86)90419-9","volume":"84","author":"SC Gad","year":"1986","unstructured":"Gad SC, Brendan J, Dunn BJ, Dobbs DW, Reilly C, Walsh RD (1986) Development and validation of an alternative dermal sensitization test: The mouse ear swelling test (MEST). Toxicol and Applied Pharmacol 84:93\u2013114. https:\/\/doi.org\/10.1016\/0041-008X(86)90419-9","journal-title":"Toxicol and Applied Pharmacol"},{"key":"834_CR12","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1111\/j.1600-0536.1994.tb00650.x","volume":"30","author":"JL Garrigue","year":"1994","unstructured":"Garrigue JL, Nicolas JF, Fraginals R, Benezra C, Bour H, Schmitt D (1994) Optimization of the mouse ear swelling test for in vivo and in vitro studies of weak contact sensitizers. Contact Dermatitis 30:231\u2013237","journal-title":"Contact Dermatitis"},{"key":"834_CR13","first-page":"143","volume-title":"Cosmeceuticals","author":"DA Glaser","year":"2016","unstructured":"Glaser DA, Prodanovic E (2016) Sunscreens. In: Draelos ZD, Dover JS, Alam M (eds) Cosmeceuticals, 3rd edn. Elsevier, Philadelphia, PA, pp 143\u2013153","edition":"3"},{"key":"834_CR14","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1097\/DER.0b013e31827edc8b","volume":"24","author":"J Greenspoon","year":"2013","unstructured":"Greenspoon J, Ahluwalia R, Juma N, Rosen CF (2013) Allergic and photoallergic contact dermatitis: a 10-year experience. Dermatitis 24:29\u201332","journal-title":"Dermatitis"},{"key":"834_CR15","doi-asserted-by":"publisher","first-page":"1004","DOI":"10.3389\/fimmu.2019.01004","volume":"10","author":"DG Helou","year":"2019","unstructured":"Helou DG, Martin SF, Pallardy M, Chollet-Martin S, Kerdine-R\u00f6me S (2019) Nrf2 involvement in chemical-induced skin innate immunity. Front Immunol 10:1004","journal-title":"Front Immunol"},{"key":"834_CR16","unstructured":"Ho AW, Thomas S. Kupper (2019) Soluble mediators of the cutaneous immune system. In: Kang S, Amagai M, Bruckner AL, Enk AH, Margolis DJ, McMichael AJ, Orringer JS (eds) Fitzpatrick\u2019s Dermatology, ninth edition. McGraw-Hill Education, pp 165, 174"},{"key":"834_CR17","doi-asserted-by":"publisher","first-page":"504","DOI":"10.1016\/0955-2863(95)00082-B","volume":"6","author":"ML Hu","year":"1995","unstructured":"Hu ML, Chen YK, Chen LC, Sano M (1995) Para-aminobenzoic acid scavenges reactive oxygen species and protects DNA against UV and free radical damage. J Nutr Biochem 6:504\u2013508","journal-title":"J Nutr Biochem"},{"issue":"12","key":"834_CR18","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1186\/1471-2164-12-12","volume":"6","author":"M Husain","year":"2011","unstructured":"Husain M, Boermans HJ, Karrow NA (2011) Mesenteric lymph node transcriptome profiles in BALB\/c mice sensitized to three common food allergens. BMC Genom 6(12):12. https:\/\/doi.org\/10.1186\/1471-2164-12-12","journal-title":"BMC Genom"},{"key":"834_CR19","doi-asserted-by":"publisher","first-page":"531","DOI":"10.1146\/annurev.immunol.25.022106.141623","volume":"30","author":"SZ Josefowicz","year":"2012","unstructured":"Josefowicz SZ, Lu LF, Rudensky AY (2012) Regulatory T cells: mechanisms of differentiation and function. Annu Rev Immunol 30:531\u2013564","journal-title":"Annu Rev Immunol"},{"key":"834_CR20","doi-asserted-by":"publisher","first-page":"282","DOI":"10.1016\/j.ejps.2016.04.003","volume":"88","author":"WR Kadhum","year":"2016","unstructured":"Kadhum WR, Oshizaka T, Ichiro H, Todo H, Sugibayashi K (2016) Usefulness of liquid\u2013crystal oral formulations to enhance the bioavailability and skin tissue targeting of p-amino benzoic acid as a model compound. Eur J Pharm Sci 88:282\u2013290","journal-title":"Eur J Pharm Sci"},{"key":"834_CR21","doi-asserted-by":"publisher","first-page":"103255","DOI":"10.1016\/j.fgb.2019.103255","volume":"132","author":"A Khurana","year":"2019","unstructured":"Khurana A, Sardana K, Chowdhary A (2019) Antifungal resistance in dermatophytes: recent trends and therapeutic implications. Fungal Genet Biol 132:103255. https:\/\/doi.org\/10.1016\/j.fgb.2019.103255","journal-title":"Fungal Genet Biol"},{"key":"834_CR22","doi-asserted-by":"publisher","first-page":"643","DOI":"10.1016\/j.immuni.2005.04.004","volume":"22","author":"A Kissenpfennig","year":"2005","unstructured":"Kissenpfennig A, Henri S, Dubois B, Laplace-Builh\u00e9 C, Perrin P, Romani N, Tripp CH, Douillard P, Leserman L, Kaiserlian D, Saeland S, Davoust J, Malissen B (2005) Dynamics and function of Langerhans cells in vivo: dermal dendritic cells colonize lymph node areas distinct from slower migrating Langerhans cells. Immunity 22:643\u2013654","journal-title":"Immunity"},{"key":"834_CR23","doi-asserted-by":"publisher","first-page":"1871","DOI":"10.2174\/0929867023368872","volume":"9","author":"A Kluzk","year":"2002","unstructured":"Kluzk A, Popek T, Kiyota T, Macedo P, Stefanowicz P, Lazar C, Konishi Y (2002) Drug evolution: p-aminobenzoic acid as a building block. Curr Med Chem 9:1871\u20131892","journal-title":"Curr Med Chem"},{"key":"834_CR24","first-page":"332","volume":"22","author":"L LaBerge","year":"2011","unstructured":"LaBerge L, Pratt M, Fong B, Gavigan G (2011) A 10-year review of p-phenylenediamine allergy and related para-amino compounds at the Ottawa patch test clinic. Dermatitis 22:332\u2013334","journal-title":"Dermatitis"},{"key":"834_CR25","doi-asserted-by":"publisher","first-page":"109687","DOI":"10.1016\/j.mehy.2020.109687","volume":"139","author":"D Lauritanoa","year":"2020","unstructured":"Lauritanoa D, Ronconib G, Caraffac A, Gallengad CE, Kritase SK, Di Emidiof P, Martinottig S, Tet\u00e8h G, Rossi R, Conti P (2020) New aspect of allergic contact dermatitis, an inflammatory skin disorder mediated by mast cells: can IL-38 help? Med Hypotheses 139:109687","journal-title":"Med Hypotheses"},{"key":"834_CR26","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1007\/s10753-015-0248-4","volume":"39","author":"W Li","year":"2016","unstructured":"Li W, Wu X, Xu X, Wang W, Song S, Liang K, Yang M, Guo L, Zhao Y, Li R (2016) Coenzyme Q10 suppresses TNF- \u03b1-induced inflammatory reaction in vitro and attenuates severity of dermatitis in mice. Inflammation 39:281\u2013289. https:\/\/doi.org\/10.1007\/s10753-015-0248-4","journal-title":"Inflammation"},{"key":"834_CR27","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1046\/j.1440-0960.1999.00319.x","volume":"40","author":"BS Mackie","year":"1999","unstructured":"Mackie BS, Mackie LE (1999) The PABA story. Australas J Dermatol 40:51\u201353","journal-title":"Australas J Dermatol"},{"key":"834_CR28","doi-asserted-by":"publisher","first-page":"918","DOI":"10.1021\/acs.molpharmaceut.9b01178","volume":"17","author":"F Martin","year":"2020","unstructured":"Martin F, Pop M, Kacso I, Grosu IG, Micl\u0103u\u0219 M, Vodnar D, Lung I, Filip GA, Olteanu ED, Moldovan R, Nagy A, Filip X, B\u00e2ldea I (2020) Ketoconazole-p-aminobenzoic acid cocrystal: revival of an old drug by crystal engineering. Mol Pharm 17:918\u2013932","journal-title":"Mol Pharm"},{"key":"834_CR29","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1016\/S0076-6879(09)63008-1","volume":"463","author":"JE Noble","year":"2009","unstructured":"Noble JE, Bailey MJ (2009) Quantitation of protein. Methods Enzymol 463:73\u201395. https:\/\/doi.org\/10.1016\/S0076-6879(09)63008-1","journal-title":"Methods Enzymol"},{"key":"834_CR30","doi-asserted-by":"publisher","first-page":"986","DOI":"10.1161\/ATVBAHA.110.207449","volume":"31","author":"E Ricciotti","year":"2011","unstructured":"Ricciotti E, Garret AGA (2011) Prostaglandins and inflammation. Arterioscler Thromb Vasc Biol 31:986\u20131000","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"834_CR31","doi-asserted-by":"publisher","first-page":"552","DOI":"10.1007\/s00403-001-0276-9","volume":"293","author":"S Sebastiani","year":"2002","unstructured":"Sebastiani S, Albanesi C, De Pit\u00e0 O, Puddu P, Cavani A, Girolomoni G (2002) The role of chemokines in allergic contact dermatitis. Arch Dermatol Res 293:552\u2013559","journal-title":"Arch Dermatol Res"},{"key":"834_CR32","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1016\/j.jand.2013.07.045","volume":"114","author":"RS Sharma","year":"2013","unstructured":"Sharma RS, Joy RC, Boushey CJ, Ferruzzi MG, Leonov AP, McCrory MA (2013) Effects of para-aminobenzoic acid (PABA) form and administration mode on PABA recovery in 24-hour urine collections. J Acad Nutr Diet 114:457\u2013463","journal-title":"J Acad Nutr Diet"},{"key":"834_CR33","volume-title":"SHELXS97 and SHELXL97","author":"GM Sheldrick","year":"1997","unstructured":"Sheldrick GM (1997) SHELXS97 and SHELXL97. University of G\u00f6ttingen, Germany"},{"key":"834_CR34","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1107\/S0108767307043930","volume":"64","author":"GM Sheldrick","year":"2008","unstructured":"Sheldrick GM (2008) A short history of SHELX. Acta Crystallogr SEct A: Found Crystallogr 64:112\u2013122","journal-title":"Acta Crystallogr SEct A: Found Crystallogr"},{"key":"834_CR35","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1186\/1471-5945-6-5","volume":"6","author":"I Stewart","year":"2006","unstructured":"Stewart I, Seawright AA, Schluter PJ, Shaw GR (2006) Primary irritant and delayed-contact hypersensitivity reactions to the freshwater cyanobacterium Cylindrospermopsis raciborskii and its associated toxin cylindrospermopsin. BMC Dermatol 6:5. https:\/\/doi.org\/10.1186\/1471-5945-6-5","journal-title":"BMC Dermatol"},{"key":"834_CR36","unstructured":"Biovia Materials Studio, release 5.5., BIOVIA (previously named Accelrys), USA https:\/\/www.3ds.com\/products-services\/biovia\/products\/molecular-modeling-simulation\/biovia-materials-studio."},{"key":"834_CR37","doi-asserted-by":"publisher","first-page":"392","DOI":"10.1016\/j.alit.2017.02.015","volume":"66","author":"K Suzuki","year":"2017","unstructured":"Suzuki K, Meguro K, Nakagomi D, Nakajima H (2017) Roles of alternatively activated M2 macrophages in allergic contact dermatitis. Allergol Int 66:392\u2013397","journal-title":"Allergol Int"},{"key":"834_CR38","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1172\/JCI11830","volume":"107","author":"PP Tak","year":"2001","unstructured":"Tak PP, Firestein GS (2001) NF-\u03baB: a key role in inflammatory diseases. J Clin Invest 107:7\u201311","journal-title":"J Clin Invest"},{"key":"834_CR39","doi-asserted-by":"publisher","first-page":"807","DOI":"10.1016\/0272-0590(91)90187-9","volume":"17","author":"PS Thorne","year":"1991","unstructured":"Thorne PS, Hawk C, Kaliszewski SD, Guiney PD (1991) The non-invasive mouse ear swelling assay: I. Refinements for detecting weak contact sensitizers. Fundam APpl ToxIcol 17:807\u2013820","journal-title":"Fundam APpl ToxIcol"},{"key":"834_CR40","first-page":"5","volume":"1","author":"P Thune","year":"1984","unstructured":"Thune P (1984) Contact and photocontact allergy to sunscreens. Photodermatol 1:5\u20139","journal-title":"Photodermatol"},{"key":"834_CR41","doi-asserted-by":"publisher","first-page":"4965","DOI":"10.1172\/JCI75660","volume":"124","author":"L Tordesillas","year":"2014","unstructured":"Tordesillas L, Goswami R, Bened\u00e9 S, Grishina G, Dunkin D, J\u00e4rvinen KM, Maleki SJ, Sampson HA, Berin MC (2014) Skin exposure promotes a Th2-dependent sensitization to peanut allergens. J Clin Invest 124:4965\u20134975","journal-title":"J Clin Invest"},{"key":"834_CR42","first-page":"614","volume":"5","author":"N Wang","year":"2014","unstructured":"Wang N, Liang H, Zen K (2014) Molecular mechanisms that influence the macrophage m1\u2013m2 polarization balance. Front Immunol 5:614","journal-title":"Front Immunol"},{"key":"834_CR43","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1248\/bpb.b13-00459","volume":"37","author":"M Zhang","year":"2014","unstructured":"Zhang M, Zhou J, Wang L, Li B, Guo J, Guan X, Han Q, Zhang H (2014) Caffeic acid reduces cutaneous tumor necrosis factor alpha (TNF- \u03b1), IL-6 and IL-1 \u03b2 levels and ameliorates skin edema in acute and chronic model of cutaneous inflammation in mice. Biol Pharm Bull 37:347\u2013354","journal-title":"Biol Pharm Bull"}],"container-title":["Inflammopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10787-021-00834-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10787-021-00834-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10787-021-00834-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,6,25]],"date-time":"2021-06-25T10:17:40Z","timestamp":1624616260000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10787-021-00834-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6]]},"references-count":43,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2021,6]]}},"alternative-id":["834"],"URL":"https:\/\/doi.org\/10.1007\/s10787-021-00834-7","relation":{},"ISSN":["0925-4692","1568-5608"],"issn-type":[{"value":"0925-4692","type":"print"},{"value":"1568-5608","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,6]]},"assertion":[{"value":"1 April 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 May 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 June 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that there are no conflicts of interest. All authors have given approval to the final version of the manuscript. The authors declare no competing financial interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"All lab animal experiments were approved by ethics committee of the University of Medicine and Pharmacy Cluj-Napoca and the Veterinary Health Directorate, Romania (authorization number 67\/ 06 06 2017).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}}]}}