{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T20:57:13Z","timestamp":1789419433028,"version":"build-2803163510"},"reference-count":65,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2021,8,7]],"date-time":"2021-08-07T00:00:00Z","timestamp":1628294400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,8,7]],"date-time":"2021-08-07T00:00:00Z","timestamp":1628294400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Inflammopharmacol"],"published-print":{"date-parts":[[2021,10]]},"DOI":"10.1007\/s10787-021-00851-6","type":"journal-article","created":{"date-parts":[[2021,8,7]],"date-time":"2021-08-07T19:02:21Z","timestamp":1628362941000},"page":"1565-1577","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Acteoside isolated from Colebrookea oppositifolia attenuates I\/R brain injury in Wistar rats via modulation of HIF-1\u03b1, NF-\u03baB, and VEGF pathways"],"prefix":"10.1007","volume":"29","author":[{"given":"Gollapalle Lakshminarayanashastry","family":"Viswanatha","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanumanthappa","family":"Shylaja","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krishnadas","family":"Nandakumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Subbanna","family":"Rajesh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"CH K. V. L. S. N. Anjana","family":"Male","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,8,7]]},"reference":[{"issue":"2","key":"851_CR1","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1007\/s12975-010-0023-7","volume":"1","author":"M Ahmad","year":"2010","unstructured":"Ahmad M, Graham SH (2010) Inflammation after stroke: mechanisms and therapeutic approaches. Transl Stroke Res 1(2):74\u201384","journal-title":"Transl Stroke Res"},{"issue":"1","key":"851_CR2","doi-asserted-by":"publisher","first-page":"138","DOI":"10.19045\/bspab.2018.70017","volume":"7","author":"M Ajaib","year":"2018","unstructured":"Ajaib M, Abid S, Anjum M, Noshad Q, Siddiqui MF, Iqbal MA (2018) Phytochemical, antibacterial and antifungal activities of leaves and bark of Colebrookea oppositifolia: an ethnomedicinal plant. Pure Appl Biol 7(1):138\u2013151","journal-title":"Pure Appl Biol"},{"issue":"23","key":"851_CR3","doi-asserted-by":"publisher","first-page":"6320","DOI":"10.1523\/JNEUROSCI.0449-07.2007","volume":"27","author":"O Baranova","year":"2007","unstructured":"Baranova O, Miranda LF, Pichiule P, Dragatsis I, Johnson RS, Chavez JC (2007) Neuron-specific inactivation of the hypoxia inducible factor 1 alpha increases brain injury in a mouse model of transient focal cerebral ischemia. J Neurosci 27(23):6320\u20136332","journal-title":"J Neurosci"},{"issue":"6","key":"851_CR4","doi-asserted-by":"publisher","first-page":"1304","DOI":"10.1161\/01.STR.17.6.1304","volume":"17","author":"JB Bederson","year":"1986","unstructured":"Bederson JB, Pitts LH, Germano SM, Nishimura MC, Davis RL, Bartkowski HM (1986) Evaluation of 2, 3, 5-triphenyltetrazolium chloride as a stain for detection and quantification of experimental cerebral infarction in rats. Stroke 17(6):1304\u20131308","journal-title":"Stroke"},{"key":"851_CR5","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1016\/0003-2697(76)90527-3","volume":"72","author":"MM Bradford","year":"1976","unstructured":"Bradford MM (1976) A rapid and sensitive method for quatitation of microgram quantities of protein utilizing the principle of proteindye binding. Anal Biochem 72:248\u2013254","journal-title":"Anal Biochem"},{"issue":"3","key":"851_CR6","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1002\/(SICI)1096-9896(200002)190:3<255::AID-PATH526>3.0.CO;2-6","volume":"190","author":"DL Carden","year":"2000","unstructured":"Carden DL, Granger DN (2000) Pathophysiology of ischaemia-reperfusion injury. J Pathol 190(3):255\u2013266","journal-title":"J Pathol"},{"key":"851_CR7","volume-title":"Council of scientifc and industrial research","author":"RN Chopra","year":"1956","unstructured":"Chopra RN, Nayar SL, Chopra IC (1956) Council of scientifc and industrial research. CSIR Publication, New Delhi, Glossary of Indian Medicinal Plants"},{"key":"851_CR8","doi-asserted-by":"publisher","first-page":"16151","DOI":"10.1038\/srep16151","volume":"5","author":"W Chuanhong","year":"2015","unstructured":"Chuanhong W, Jianxin C, Chang C, Wei W, Limei W, Kuo G et al (2015) Wnt\/\u03b2-catenin coupled with HIF-1\u03b1\/VEGF signaling pathways involved in galangin neurovascular unit protection from focal cerebral ischemia. Sci Rep 5:16151","journal-title":"Sci Rep"},{"key":"851_CR9","first-page":"29","volume-title":"Handbook of methods for oxygen radical research","author":"A Claiborne","year":"1985","unstructured":"Claiborne A (1985) Handbook of methods for oxygen radical research. CRC Press, Boca Raton, p 29"},{"issue":"3","key":"851_CR10","first-page":"167","volume":"2","author":"SK Devendra","year":"2012","unstructured":"Devendra SK, Mohd TS, Hemant K, Singh., Ali, A., Verma, V.K. (2012) In vivo hepatoprotective potential of nigella sativa extract against rifampicin induced sub-chronic hepatotoxicity and altered redox status. J Biol Active Subst Nat 2(3):167\u2013177","journal-title":"J Biol Active Subst Nat"},{"issue":"1","key":"851_CR11","doi-asserted-by":"publisher","first-page":"364","DOI":"10.1080\/0886022X.2018.1450762","volume":"40","author":"L Gan","year":"2018","unstructured":"Gan L, Li X, Zhu M, Chen C, Luo H, Zhou Q (2018) Acteoside relieves mesangial cell injury by regulating Th22 cell chemotaxis and proliferation in IgA nephropathy. Ren Fail 40(1):364\u2013370","journal-title":"Ren Fail"},{"key":"851_CR12","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1016\/j.neuropharm.2015.12.002","volume":"103","author":"S Gao","year":"2016","unstructured":"Gao S, Mo J, Chen L, Wang Y, Mao X, Shi Y et al (2016) Astrocyte GGTI-mediated Rac1 prenylation upregulates NF-kappa-B expression and promotes neuronal apoptosis following hypoxia\/ischemia. Neuropharmacol 103:44\u201356","journal-title":"Neuropharmacol"},{"issue":"51","key":"851_CR13","doi-asserted-by":"publisher","first-page":"6680","DOI":"10.1038\/sj.onc.1209954","volume":"25","author":"TD Gilmore","year":"2006","unstructured":"Gilmore TD (2006) Introduction to NF-\u03baB: Players, pathways, perspectives. Oncogene 25(51):6680\u20136684","journal-title":"Oncogene"},{"issue":"3","key":"851_CR14","doi-asserted-by":"publisher","first-page":"236","DOI":"10.1016\/S0367-326X(00)00311-7","volume":"72","author":"RS Gupt","year":"2001","unstructured":"Gupt RS, Yadav RK, Dixit VP, Dobhal MP (2001) Antifertility studies of Colebrookea oppositifolia leaf extract in male rats with special reference to testicular cell population dynamics. Fitoterapia 72(3):236\u2013245","journal-title":"Fitoterapia"},{"issue":"3","key":"851_CR15","first-page":"310","volume":"2","author":"PK Haldar","year":"2011","unstructured":"Haldar PK, Kush B, Arun Kumar P, Girraj T, Braj KT, Devendra Singh NS, Dhananjay G, Shivani K, Glob J (2011) In vitro\u2013in vivo evaluation of cardioprotective effect of the leaf extract of Colebrookea oppositifolia sm. Trends Pharm Sci 2(3):310\u2013324","journal-title":"Trends Pharm Sci"},{"key":"851_CR16","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1111\/j.1749-6632.2010.05735.x","volume":"1207","author":"OA Harari","year":"2010","unstructured":"Harari OA, Liao JK (2010) NF-\u03baB and innate immunity in ischemic stroke. Ann N Y Acad Sci 1207:32\u201340","journal-title":"Ann N Y Acad Sci"},{"issue":"16","key":"851_CR17","doi-asserted-by":"publisher","first-page":"4099","DOI":"10.1523\/JNEUROSCI.4555-04.2005","volume":"25","author":"R Helton","year":"2005","unstructured":"Helton R, Cui J, Scheel JR, Ellison JA, Ames C, Gibson C et al (2005) Brain-specific knock-out of hypoxia-inducible factor-1alpha reduces rather than increases hypoxic-ischemic damage. J Neurosci 25(16):4099\u20134107","journal-title":"J Neurosci"},{"key":"851_CR18","doi-asserted-by":"publisher","first-page":"2347","DOI":"10.2174\/138161208785740054","volume":"14","author":"CJ Hillard","year":"2008","unstructured":"Hillard CJ (2008) Role of cannabinoids and endocannabinoids in cerebral ischemia. Curr Pharm Des 14:2347\u20132361","journal-title":"Curr Pharm Des"},{"issue":"6","key":"851_CR19","doi-asserted-by":"publisher","first-page":"743","DOI":"10.1016\/S0361-9230(00)00348-8","volume":"53","author":"JT Hong","year":"2000","unstructured":"Hong JT, Ryu SR, Kim HJ, Lee JK, Lee SH, Kim DB, Yun YP, Ryu JH, Lee BM, Kim PY (2000) Neuroprotective effect of green tea extract in experimental ischemia-reperfusion brain injury. Brain Res Bull 53(6):743\u2013749","journal-title":"Brain Res Bull"},{"issue":"Suppl 1","key":"851_CR20","doi-asserted-by":"publisher","first-page":"S103","DOI":"10.1002\/mnfr.201000336","volume":"55","author":"YP Hwang","year":"2011","unstructured":"Hwang YP, Kim HG, Choi JH, Park BH, Jeong MH, Jeong TC et al (2011) Acteoside inhibits PMA-induced matrix metalloproteinase-9 expression via CaMK\/ERK- and JNK\/NF-\u03baB-dependent signaling. Mol Nutr Food Res 55(Suppl 1):S103\u2013S116","journal-title":"Mol Nutr Food Res"},{"issue":"Pt 17","key":"851_CR21","doi-asserted-by":"publisher","first-page":"4137","DOI":"10.1113\/jphysiol.2011.210831","volume":"589","author":"C Iadecola","year":"2011","unstructured":"Iadecola C, Kahles T, Gallo EF, Anrather J (2011) Neurovascular protection by ischaemic tolerance: role of nitric oxide. J Physiol 589(Pt 17):4137\u20134145","journal-title":"J Physiol"},{"issue":"3","key":"851_CR22","doi-asserted-by":"publisher","first-page":"702","DOI":"10.1016\/j.jaci.2011.11.052","volume":"129","author":"E Ingelsson","year":"2012","unstructured":"Ingelsson E, Yin L, B\u00e4ck M (2012) Nationwide cohort study of the leukotriene receptor antagonist montelukast and incident or recurrent cardiovascular disease. J Allergy Clin Immunol 129(3):702-707.e2","journal-title":"J Allergy Clin Immunol"},{"key":"851_CR23","doi-asserted-by":"publisher","first-page":"242","DOI":"10.1097\/PAF.0b013e31828879cd","volume":"34","author":"Y Kakimoto","year":"2013","unstructured":"Kakimoto Y, Tsuruyama T, Miyao M, Abiru H, Sumiyoshi S, Kotani H et al (2013) The effectiveness and limitations of triphenyltetrazolium chloride to detect acute myocardial infarction at forensic autopsy. Am J Forensic Med Pathol 34:242\u2013247","journal-title":"Am J Forensic Med Pathol"},{"issue":"91","key":"851_CR24","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1254\/jphs.91.305","volume":"2003","author":"Y Karasawa","year":"2003","unstructured":"Karasawa Y, Komiyama H, Yoshida S, Hino N, Katsuura Y, Nakaike S, Araki H (2003) Effect of TTC-909 on cerebral infarction following permanent occlusion of the middle cerebral artery in stroke prone spontaneously hypertensive rats. J Pharmacol Sci 2003(91):305\u2013312","journal-title":"J Pharmacol Sci"},{"issue":"7","key":"851_CR25","doi-asserted-by":"publisher","first-page":"683","DOI":"10.1016\/j.neuint.2009.06.014","volume":"55","author":"PS Khansari","year":"2009","unstructured":"Khansari PS, Halliwell RF (2009) Evidence for neuroprotection by the fenamate NSAID, mefenamic acid. Neurochem Int 55(7):683\u2013688","journal-title":"Neurochem Int"},{"key":"851_CR26","doi-asserted-by":"publisher","first-page":"64","DOI":"10.3389\/fnins.2019.00064","volume":"13","author":"PS Khansari","year":"2019","unstructured":"Khansari PS, Halliwell RF (2019) Mechanisms Underlying Neuroprotection by the NSAID Mefenamic Acid in an Experimental Model of Stroke. Front Neurosci 13:64. https:\/\/doi.org\/10.3389\/fnins.2019.00064","journal-title":"Front Neurosci"},{"issue":"3","key":"851_CR27","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1007\/s10787-012-0124-x","volume":"20","author":"PS Khansari","year":"2012","unstructured":"Khansari PS, Sperlagh B (2012) Inflammation in neurological and psychiatric diseases. Inflammopharmacology 20(3):103\u2013107","journal-title":"Inflammopharmacology"},{"key":"851_CR28","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1016\/j.intimp.2019.01.020","volume":"69","author":"M Khullar","year":"2019","unstructured":"Khullar M, Sharma A, Wani A, Sharma N, Sharma N, Chandan BK et al (2019) Acteoside ameliorates inflammatory responses through NFkB pathway in alcohol induced hepatic damage. Int Immunopharmacol 69:109\u2013117","journal-title":"Int Immunopharmacol"},{"key":"851_CR29","volume-title":"Indian medicinal plants, 1987 edition","author":"KR Kritikar","year":"1987","unstructured":"Kritikar KR, Basu BD (1987) Indian medicinal plants, 1987 edition, 4th edn. International Publishers, Deheradun","edition":"4"},{"key":"851_CR30","first-page":"217","volume":"41","author":"J Lerma","year":"1992","unstructured":"Lerma J, Martin del Rio R (1992) Chloride transport blockers prevent N-methyl-Daspartate receptor-channel complex activation. Mol Pharmacol 41:217\u2013222","journal-title":"Mol Pharmacol"},{"issue":"4","key":"851_CR31","doi-asserted-by":"publisher","first-page":"1135","DOI":"10.3390\/ijms19041135","volume":"19","author":"M Li","year":"2018","unstructured":"Li M, Xu T, Zhou F, Wang M, Song H, Xiao X, Lu B (2018a) Neuroprotective effects of four phenylethanoid glycosides on H2O2-induced apoptosis on PC12 Cells via the Nrf2\/ARE Pathway. Int J Mol Sci 19(4):1135","journal-title":"Int J Mol Sci"},{"issue":"2","key":"851_CR32","doi-asserted-by":"publisher","first-page":"498","DOI":"10.3390\/molecules23020498","volume":"23","author":"X Li","year":"2018","unstructured":"Li X, Xie Y, Li K, Wu A, Xie H, Guo Q et al (2018b) Antioxidation and cytoprotection of acteoside and its derivatives: comparison and mechanistic chemistry. Molecules (basel, Switzerland) 23(2):498","journal-title":"Molecules (basel, Switzerland)"},{"issue":"1","key":"851_CR33","doi-asserted-by":"publisher","first-page":"936","DOI":"10.1186\/s12885-020-07447-3","volume":"20","author":"D Ma","year":"2020","unstructured":"Ma D, Wang J, Liu L, Chen M, Wang Z (2020) Acteoside as a potential therapeutic option for primary hepatocellular carcinoma: a preclinical study. BMC Cancer 20(1):936","journal-title":"BMC Cancer"},{"key":"851_CR34","volume-title":"Flowering plants of chittoor district\u2014Andhra Pradesh, India","author":"K Madhava Chetty","year":"2008","unstructured":"Madhava Chetty K, Sivaji K, Tulasi RK (2008) Flowering plants of chittoor district\u2014Andhra Pradesh, India, 1st edn. Students Offset Printers, Tirupati","edition":"1"},{"key":"851_CR35","volume-title":"Indian material medica","author":"KM Nadkarni","year":"1976","unstructured":"Nadkarni KM (1976) Indian material medica, vol 1. Bombay Popular Prakashan, Bombay"},{"issue":"2","key":"851_CR36","doi-asserted-by":"publisher","first-page":"574","DOI":"10.1016\/j.intimp.2015.09.026","volume":"29","author":"SY Nam","year":"2015","unstructured":"Nam SY, Kim HM, Jeong HJ (2015) Attenuation of IL-32-induced caspase-1 and nuclear factor-\u03baB activations by acteoside. Int Immunopharmacol 29(2):574\u2013582","journal-title":"Int Immunopharmacol"},{"issue":"58","key":"851_CR37","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1016\/S0090-6980(99)00024-6","volume":"1999","author":"S Nishimaki","year":"1999","unstructured":"Nishimaki S, Seki K (1999) An imbalance between prostacyclin and thromboxane in relation to cerebral blood flow in neonates with maternal preeclampsia. Prostaglandins Other Lipid Mediat 1999(58):43\u201349","journal-title":"Prostaglandins Other Lipid Mediat"},{"issue":"1","key":"851_CR38","first-page":"296","volume":"2","author":"RB Nishith","year":"2012","unstructured":"Nishith RB, Himadri SP, Prasanna KK, Prakash KH, Subhankar N, Harikant T (2012) In vitro evaluation of antioxidant activity of Colebrookea oppositifolia Smith. Int J Drug Dis Herb Res 2(1):296\u2013300","journal-title":"Int J Drug Dis Herb Res"},{"issue":"902","key":"851_CR39","doi-asserted-by":"publisher","first-page":"264","DOI":"10.1016\/S0006-8993(01)02354-X","volume":"2001","author":"H Ohyama","year":"2001","unstructured":"Ohyama H, Hosomi N, Takahashi T, Mizushige K, Kohno M (2001) Thrombin inhibition attenuates neurodegeneration and cerebral edema formation following transient forebrain ischemia. Brain Res 2001(902):264\u2013271","journal-title":"Brain Res"},{"key":"851_CR40","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1016\/S0006-8993(00)02275-7","volume":"867","author":"LD Partridge","year":"2000","unstructured":"Partridge LD, Valenzuela CF (2000) Block of hippocampal CAN channels by flufenamate. Brain Res 867:143\u2013148","journal-title":"Brain Res"},{"issue":"7","key":"851_CR41","doi-asserted-by":"publisher","first-page":"1783","DOI":"10.2337\/db06-1601","volume":"56","author":"J Pi","year":"2007","unstructured":"Pi J, Bai Y, Zhang Q, Wong V, Floering LM, Daniel K, Collins S (2007) Reactive oxygen species as a signal in glucose-stimulated insulin secretion. Diabetes 56(7):1783\u20131791","journal-title":"Diabetes"},{"issue":"8","key":"851_CR42","doi-asserted-by":"publisher","first-page":"525","DOI":"10.1080\/09553000600876686","volume":"82","author":"KR Prabhakar","year":"2006","unstructured":"Prabhakar KR, Veerapur VP, Parihar KV, Priyadarsini KI, Rao BSS, Unnikrishnan MK (2006) Evaluation and optimization of radioprotective activity of Coronopus didymus Linn. in gamma-irradiated mice. Int J Radiat Biol 82(8):525\u2013536","journal-title":"Int J Radiat Biol"},{"issue":"4","key":"851_CR43","first-page":"109","volume":"10","author":"H Qiu","year":"2013","unstructured":"Qiu H, Fan W, Fu P, Zuo C, Feng P, Liu F et al (2013) General acteoside of Rehmanniae leaves in the treatment of primary chronic glomerulonephritis: a randomized controlled trial. Afr J Tradit Complem Alternat Med 10(4):109\u2013115","journal-title":"Afr J Tradit Complem Alternat Med"},{"key":"851_CR44","doi-asserted-by":"publisher","first-page":"2088","DOI":"10.1016\/j.jstrokecerebrovasdis.2015.05.009","volume":"24","author":"PW Ribeiro","year":"2015","unstructured":"Ribeiro PW, Cola PC, Gatto AR, da Silva RG, Luvizutto GJ, Braga GP et al (2015) Relationship between dysphagia, national institutes of health stroke scale score, and predictors of pneumonia after ischemic stroke. J Stroke Cerebrovasc Dis 24:2088\u20132094","journal-title":"J Stroke Cerebrovasc Dis"},{"key":"851_CR45","doi-asserted-by":"publisher","first-page":"1230","DOI":"10.1016\/j.biopha.2017.11.093","volume":"96","author":"FTS Rodrigues","year":"2017","unstructured":"Rodrigues FTS, de Sousa CNS, Ximenes NC, Almeida AB, Cabral LM, Patrocinio CFV (2017) Effects of standard ethanolic extract from Erythrina velutina in acute cerebral ischemia in mice. Biomed Pharmacother 96:1230\u20131239","journal-title":"Biomed Pharmacother"},{"issue":"1","key":"851_CR46","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1007\/s11064-014-1478-9","volume":"40","author":"MA Saad","year":"2015","unstructured":"Saad MA, Abdelsalam RM, Kenawy SA, Attia AS (2015) Montelukast, a cysteinyl leukotriene receptor-1 antagonist protects against hippocampal injury induced by transient global cerebral ischemia and reperfusion in rats. Neurochem Res 40(1):139\u2013150","journal-title":"Neurochem Res"},{"key":"851_CR47","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1016\/j.jep.2013.08.052","volume":"150","author":"J Sharma","year":"2013","unstructured":"Sharma J, Gairola S, Gaur RD, Painuli RM, Siddiqi TO (2013) Ethnomedicinal plants used for treating epilepsy by indigenous communities of sub-Himalayan region of Uttarakhand. India J Ethnopharmacol 150:353\u2013370","journal-title":"India J Ethnopharmacol"},{"issue":"4","key":"851_CR48","doi-asserted-by":"publisher","first-page":"895","DOI":"10.3390\/ijms18040895","volume":"18","author":"YJ Shiao","year":"2017","unstructured":"Shiao YJ, Su MH, Lin HC, Wu CR (2017) Acteoside and Isoacteoside protect amyloid \u03b2 peptide induced cytotoxicity, cognitive deficit and neurochemical disturbances in vitro and in vivo. Int J Mol Sci 18(4):895","journal-title":"Int J Mol Sci"},{"issue":"3","key":"851_CR49","doi-asserted-by":"publisher","first-page":"531","DOI":"10.1016\/S0306-4522(02)00954-5","volume":"117","author":"R Tanaka","year":"2003","unstructured":"Tanaka R, Komine-Kobayashi M, Mochizuki H, Yamada M, Furuya T, Migita M et al (2003) Migration of enhanced green fluorescent protein expressing bone marrow-derived microglia\/macrophage into the mouse brain following permanent focal ischemia. Neuroscience 117(3):531\u2013539","journal-title":"Neuroscience"},{"issue":"3","key":"851_CR50","doi-asserted-by":"publisher","first-page":"358","DOI":"10.1038\/jcbfm.1990.65","volume":"10","author":"F Tegtmeier","year":"1990","unstructured":"Tegtmeier F, Weber C, Heister U, Haker I, Scheller D, Nikolov R, H\u00f6ller M (1990) Eicosanoids in rat brain during ischemia and reperfusion\u2013correlation to DC depolarization. J Cereb Blood Flow Metab 10(3):358\u2013364","journal-title":"J Cereb Blood Flow Metab"},{"issue":"1","key":"851_CR51","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/BF00229648","volume":"95","author":"M Tsuchiya","year":"1993","unstructured":"Tsuchiya M, Sako K, Yura S, Yonemasu Y (1993) Local cerebral glucose utilisation following acute and chronic bilateral carotid artery ligation in Wistar rats: relation to changes in local cerebral blood flow. Exp Brain Res 95(1):1\u20137","journal-title":"Exp Brain Res"},{"issue":"1\u20133","key":"851_CR52","doi-asserted-by":"publisher","first-page":"286","DOI":"10.1016\/j.ejphar.2013.10.016","volume":"720","author":"GL Viswanatha","year":"2013","unstructured":"Viswanatha GL, Shylaja H, Mohan CG (2013) Alleviation of transient global ischemia\/reperfusion-induced brain injury in rats with 1,2,3,4,6-penta-O-galloyl-\u03b2-d-glucopyranose isolated from Mangifera indica. Eur J Pharmacol 720(1\u20133):286\u2013293","journal-title":"Eur J Pharmacol"},{"issue":"7\u20138","key":"851_CR53","doi-asserted-by":"publisher","first-page":"1008","DOI":"10.1016\/j.nut.2015.02.009","volume":"31","author":"GL Viswanatha","year":"2015","unstructured":"Viswanatha GL, Kumar LM, Rafiq M, Kavya KJ, Thippeswamy AH, Yuvaraj HC et al (2015) LC-MS\/MS profiling and neuroprotective effects of Mentat\u00ae against transient global ischemia and reperfusion-induced brain injury in rats. Nutrition 31(7\u20138):1008\u20131017","journal-title":"Nutrition"},{"key":"851_CR54","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1016\/j.jep.2018.05.009","volume":"223","author":"GL Viswanatha","year":"2018","unstructured":"Viswanatha GL, Venkataranganna MV, Prasad NBL, Hanumanthappa S (2018) Chemical characterization and cerebroprotective effect of methanolic root extract of Colebrookea oppositifolia in rats. J Ethnopharmacol 223:63\u201375","journal-title":"J Ethnopharmacol"},{"key":"851_CR55","first-page":"250","volume":"3","author":"GL Viswanatha","year":"2020","unstructured":"Viswanatha GL, Drishya M, Kishore DV, Shylaja H, Moolemath Y et al (2020a) Characterization and Anti-stroke Activity of Stem Extract of Colebrookea oppositifolia Smith. J. Biol. Active Products Nat. 3:250\u2013263","journal-title":"J. Biol. Active Products Nat."},{"issue":"4","key":"851_CR56","doi-asserted-by":"publisher","first-page":"1010","DOI":"10.1007\/s12640-020-00267-0","volume":"38","author":"GL Viswanatha","year":"2020","unstructured":"Viswanatha GL, Shylaja H, Kishore DV, Venkataranganna MV, Prasad NBL (2020b) Acteoside Isolated from Colebrookea oppositifolia Smith Attenuates Epilepsy in Mice Via Modulation of Gamma-Aminobutyric Acid Pathways. Neurotox Res 38(4):1010\u20131023","journal-title":"Neurotox Res"},{"issue":"4","key":"851_CR57","doi-asserted-by":"publisher","first-page":"368","DOI":"10.1007\/s12640-011-9292-5","volume":"21","author":"HQ Wang","year":"2012","unstructured":"Wang HQ, Xu YX, Zhu CQ (2012) Upregulation of heme oxygenase-1 by acteoside through ERK and PI3 K\/Akt pathway confer neuroprotection against beta-amyloid-induced neurotoxicity. Neurotox Res 21(4):368\u2013378","journal-title":"Neurotox Res"},{"key":"851_CR58","doi-asserted-by":"publisher","DOI":"10.1007\/s12013-020-00965-8","author":"W Wu","year":"2021","unstructured":"Wu W, Wu G, Cao D (2021) Acteoside presents protective effects on cerebral ischemia\/reperfusion injury through targeting CCL2, CXCL10, and ICAM1. Cell Biochem Biophys. https:\/\/doi.org\/10.1007\/s12013-020-00965-8","journal-title":"Cell Biochem Biophys"},{"issue":"11","key":"851_CR59","doi-asserted-by":"publisher","first-page":"1645","DOI":"10.1248\/bpb.b18-00210","volume":"41","author":"D Xia","year":"2018","unstructured":"Xia D, Zhang Z, Zhao Y (2018) Acteoside attenuates oxidative stress and neuronal apoptosis in rats with focal cerebral ischemia-reperfusion injury. Biol Pharm Bull 41(11):1645\u20131651","journal-title":"Biol Pharm Bull"},{"issue":"14","key":"851_CR60","doi-asserted-by":"publisher","first-page":"1443","DOI":"10.2174\/138161208784480144","volume":"2008","author":"H Yang","year":"2008","unstructured":"Yang H, Chen C (2008) Cyclooxygenase-2 in synaptic signaling. Curr Pharm Des 2008(14):1443\u20131451","journal-title":"Curr Pharm Des"},{"key":"851_CR61","unstructured":"Yoganarasimhan SN. Medicinal Plants of India, Vol. 2, Tamil Nadu: Bangalore: Cybermedia, 2000, 152"},{"issue":"1","key":"851_CR62","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1159\/000081072","volume":"73","author":"GL Yu","year":"2005","unstructured":"Yu GL, Wei EQ, Zhang SH, Xu HM, Chu LS, Zhang WP, Zhang Q, Chen Z, Mei RH, Zhao MH (2005) Montelukast, a cysteinyl leukotriene receptor-1 antagonist, dose- and time-dependently protects against focal cerebral ischemia in mice. Pharmacology 73(1):31\u201340","journal-title":"Pharmacology"},{"key":"851_CR63","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1186\/1744-9081-10-42","volume":"10","author":"L Yu","year":"2014","unstructured":"Yu L, Yang B, Wang J, Zhao L, Luo W, Jiang Q, Yang J (2014) Time course change of COX2-PGI2\/TXA2 following global cerebral ischemia reperfusion injury in rat hippocampus. Behavioral and Brain Functions\u202f: BBF 10:42. https:\/\/doi.org\/10.1186\/1744-9081-10-42","journal-title":"Behavioral and Brain Functions : BBF"},{"issue":"9","key":"851_CR64","doi-asserted-by":"publisher","first-page":"e0162696","DOI":"10.1371\/journal.pone.0162696","volume":"11","author":"J Yuan","year":"2016","unstructured":"Yuan J, Ren J, Wang Y, He X, Zhao Y (2016) Acteoside Binds to Caspase-3 and Exerts Neuroprotection in the Rotenone Rat Model of Parkinson\u2019s Disease. PLoS ONE 11(9):e0162696","journal-title":"PLoS ONE"},{"issue":"4","key":"851_CR65","doi-asserted-by":"publisher","first-page":"550","DOI":"10.1111\/j.2042-7158.2010.01238.x","volume":"63","author":"R Zhao","year":"2011","unstructured":"Zhao R, Shi WZ, Zhang YM, Fang SH, Wei EQ (2011) Montelukast, a cysteinyl leukotriene receptor-1 antagonist, attenuates chronic brain injury after focal cerebral ischaemia in mice and rats. J Pharm Pharmacol 63(4):550\u2013557","journal-title":"J Pharm Pharmacol"}],"container-title":["Inflammopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10787-021-00851-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10787-021-00851-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10787-021-00851-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,10,13]],"date-time":"2021-10-13T22:45:46Z","timestamp":1634165146000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10787-021-00851-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8,7]]},"references-count":65,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2021,10]]}},"alternative-id":["851"],"URL":"https:\/\/doi.org\/10.1007\/s10787-021-00851-6","relation":{},"ISSN":["0925-4692","1568-5608"],"issn-type":[{"value":"0925-4692","type":"print"},{"value":"1568-5608","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,8,7]]},"assertion":[{"value":"6 July 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 July 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 August 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Authors declare no conflicts of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflicts of interest"}}]}}