{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T14:38:11Z","timestamp":1784299091480,"version":"3.55.0"},"reference-count":42,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2021,11,7]],"date-time":"2021-11-07T00:00:00Z","timestamp":1636243200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2021,11,7]],"date-time":"2021-11-07T00:00:00Z","timestamp":1636243200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Inflammopharmacol"],"published-print":{"date-parts":[[2021,12]]},"DOI":"10.1007\/s10787-021-00887-8","type":"journal-article","created":{"date-parts":[[2021,11,7]],"date-time":"2021-11-07T16:02:10Z","timestamp":1636300930000},"page":"1795-1805","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Effects of hydroxychloroquine and its metabolites in patients with connective tissue diseases"],"prefix":"10.1007","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8564-1824","authenticated-orcid":false,"given":"Duygu","family":"Eryavuz Onmaz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dilek","family":"Tezcan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sedat","family":"Abusoglu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sema","family":"Yilmaz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatma Humeyra","family":"Yerlikaya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mustafa","family":"Onmaz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gulsum","family":"Abusoglu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Unlu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,11,7]]},"reference":[{"issue":"9","key":"887_CR1","doi-asserted-by":"publisher","first-page":"2569","DOI":"10.1002\/art.27584","volume":"62","author":"D Aletaha","year":"2010","unstructured":"Aletaha D, Neogi T, Silman AJ, Funovits J, Felson DT, Bingham CO 3rd, Birnbaum NS, Burmester GR, Bykerk VP, Cohen MD, Combe B, Costenbader KH, Dougados M, Emery P, Ferraccioli G, Hazes JM, Hobbs K, Huizinga TW, Kavanaugh A, Kay J, Kvien TK, Laing T, Mease P, M\u00e9nard HA, Moreland LW, Naden RL, Pincus T, Smolen JS, Stanislawska-Biernat E, Symmons D, Tak PP, Upchurch KS, Vencovsk\u00fd J, Wolfe F, Hawker G (2010) 2010 Rheumatoid arthritis classification criteria: an American college of rheumatology\/European league against rheumatism collaborative initiative. Arthritis Rheum 62(9):2569\u20132581. https:\/\/doi.org\/10.1002\/art.27584","journal-title":"Arthritis Rheum"},{"key":"887_CR2","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1111\/j.1542-474X.1997.tb00325.x","volume":"2","author":"H Bazett","year":"2006","unstructured":"Bazett H (2006) An analysis of the time relationships of electrocardiograms. Ann Noninvasive Electrocardiol 2:177\u2013194. https:\/\/doi.org\/10.1111\/j.1542-474X.1997.tb00325.x","journal-title":"Ann Noninvasive Electrocardiol"},{"issue":"1","key":"887_CR3","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1186\/s13075-020-02291-z","volume":"22","author":"B Blanchet","year":"2020","unstructured":"Blanchet B, Jallouli M, Allard M, Ghillani-Dalbin P, Galicier L, Auma\u00eetre O, Chasset F, Le Guern V, Liot\u00e9 F, Smail A, Limal N, Perard L, Desmurs-Clavel H, Le Thi HD, Asli B, Kahn J-E, Sailler L, Ackermann F, Papo T, Sacr\u00e9 K, Fain O, Stirnemann J, Cacoub P, Leroux G, Cohen-Bittan J, Sellam J, Mariette X, Goulvestre C, Hulot JS, Amoura Z, Vidal M, Piette J-C, Astudillo L, Belizna C, Belmatoug N, Benveniste O, Benyamine A, Bezanahary H, Blanco P, Bodaghi B, Bourgeois P, Brihaye B, Chatelus E, Damade R, Daugas E, De Gennes C, Delfraissy J-F, Delluc C, Delluc A, Duhaut P, Dupuy A, Durieu I, Ea HK, Farge D, Funck-Brentano C, Gandjbakhch F, Gellen-Dautremer J, Godeau B, Goujard C, Grandpeix C, Grange C, Grimaldi L, Guettrot-Imbert G, Guillevin L, Hachulla E, Harle J-R, Haroche J, Hausfater P, Jouquan J, Kaplanski G, Keshtmand H, Khellaf M, Lambotte O, Launay D, Lechat P, Levesque H, Lidove O, Liozon E, Ly K, Mahevas M, Mariampillai K, Mathian A, Mazodier K, Michel M, Morel N, Mouthon L, Musset L, Ngack R, Ninet J, Oksenhendler E, Pellegrin J-L, Peyr O, Piette A-M, Poindron V, Pourrat J, Roux F, Saadoun D, Sahali S, Saint-Marcoux B, Sarrot-Reynauld F, Schoindre Y, Sene D, Serratrice J, Seve P, Sibilia J, Simon C, Sordet C, Terrier B, Trad S, Viallard J-F, Vidal E, Wechsler B, Weiller P-J, Jourde-Chiche N, Costedoat-Chalumeau N (2020) Hydroxychloroquine levels in patients with systemic lupus erythematosus: whole blood is preferable but serum levels also detect non-adherence. Arthritis Res Ther 22(1):223. https:\/\/doi.org\/10.1186\/s13075-020-02291-z","journal-title":"Arthritis Res Ther"},{"issue":"1","key":"887_CR4","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1186\/s13075-020-02211-1","volume":"22","author":"H Carlsson","year":"2020","unstructured":"Carlsson H, Hjorton K, Abujrais S, R\u00f6nnblom L, \u00c5kerfeldt T, Kultima K (2020) Measurement of hydroxychloroquine in blood from SLE patients using LC-HRMS\u2014evaluation of whole blood, plasma, and serum as sample matrices. Arthritis Res Ther 22(1):125. https:\/\/doi.org\/10.1186\/s13075-020-02211-1","journal-title":"Arthritis Res Ther"},{"issue":"2","key":"887_CR5","doi-asserted-by":"publisher","first-page":"215","DOI":"10.3785\/j.issn.1008-9292.2020.03.03","volume":"49","author":"J Chen","year":"2020","unstructured":"Chen J, Liu D, Liu L, Liu P, Xu Q, Xia L, Ling Y, Huang D, Song S, Zhang D, Qian Z, Li T, Shen Y, Lu H (2020a) A pilot study of hydroxychloroquine in treatment of patients with moderate COVID-19. Zhejiang Da Xue Xue Bao Yi Xue Ban 49(2):215\u2013219. https:\/\/doi.org\/10.3785\/j.issn.1008-9292.2020.03.03","journal-title":"Zhejiang Da Xue Xue Bao Yi Xue Ban"},{"issue":"1","key":"887_CR6","doi-asserted-by":"publisher","first-page":"460","DOI":"10.1186\/s12967-020-02623-2","volume":"18","author":"Z Chen","year":"2020","unstructured":"Chen Z, Ding S, Wang YP, Chen L, Mao JY, Yang Y, Sun JT, Yang K (2020b) Association of carbamylated high-density lipoprotein with coronary artery disease in type 2 diabetes mellitus: carbamylated high-density lipoprotein of patients promotes monocyte adhesion. J Transl Med 18(1):460. https:\/\/doi.org\/10.1186\/s12967-020-02623-2","journal-title":"J Transl Med"},{"issue":"11","key":"887_CR7","doi-asserted-by":"publisher","first-page":"2092","DOI":"10.3899\/jrheum.150379","volume":"42","author":"L Durcan","year":"2015","unstructured":"Durcan L, Clarke WA, Magder LS, Petri M (2015) Hydroxychloroquine blood levels in systemic lupus erythematosus: clarifying dosing controversies and improving adherence. J Rheumatol 42(11):2092\u20132097. https:\/\/doi.org\/10.3899\/jrheum.150379","journal-title":"J Rheumatol"},{"issue":"1","key":"887_CR8","doi-asserted-by":"publisher","first-page":"105949","DOI":"10.1016\/j.ijantimicag.2020.105949","volume":"56","author":"P Gautret","year":"2020","unstructured":"Gautret P, Lagier J-C, Parola P, Hoang VT, Meddeb L, Mailhe M, Doudier B, Courjon J, Giordanengo V, Vieira VE, Tissot Dupont H, Honor\u00e9 S, Colson P, Chabri\u00e8re E, La Scola B, Rolain J-M, Brouqui P, Raoult D (2020) Hydroxychloroquine and azithromycin as a treatment of COVID-19: results of an open-label non-randomized clinical trial. Int J Antimicrob Agents 56(1):105949\u2013105949. https:\/\/doi.org\/10.1016\/j.ijantimicag.2020.105949","journal-title":"Int J Antimicrob Agents"},{"key":"887_CR9","unstructured":"Guidance for Industry, Bionanalytical Method Validation (2018) US Department of Health and Human Services\/Food and Drug Administration Centre for Drug Evaluation and Research (CDER)\/Centre for Veterinary Medicine (CVM)"},{"issue":"11","key":"887_CR10","doi-asserted-by":"publisher","first-page":"1930","DOI":"10.1016\/j.hrthm.2020.06.029","volume":"17","author":"M Hooks","year":"2020","unstructured":"Hooks M, Bart B, Vardeny O, Westanmo A, Adabag S (2020) Effects of hydroxychloroquine treatment on QT interval. Heart Rhythm 17(11):1930\u20131935. https:\/\/doi.org\/10.1016\/j.hrthm.2020.06.029","journal-title":"Heart Rhythm"},{"issue":"21","key":"887_CR11","doi-asserted-by":"publisher","first-page":"2030","DOI":"10.1056\/NEJMoa2022926","volume":"383","author":"P Horby","year":"2020","unstructured":"Horby P, Mafham M, Linsell L, Bell JL, Staplin N, Emberson JR, Wiselka M, Ustianowski A, Elmahi E, Prudon B, Whitehouse T, Felton T, Williams J, Faccenda J, Underwood J, Baillie JK, Chappell LC, Faust SN, Jaki T, Jeffery K, Lim WS, Montgomery A, Rowan K, Tarning J, Watson JA, White NJ, Juszczak E, Haynes R, Landray MJ (2020) Effect of hydroxychloroquine in hospitalized patients with Covid-19. N Engl J Med 383(21):2030\u20132040. https:\/\/doi.org\/10.1056\/NEJMoa2022926","journal-title":"N Engl J Med"},{"issue":"8","key":"887_CR12","doi-asserted-by":"publisher","first-page":"2176","DOI":"10.1002\/art.39194","volume":"67","author":"M Jallouli","year":"2015","unstructured":"Jallouli M, Galicier L, Zahr N, Auma\u00eetre O, Franc\u00e8s C, Le Guern V, Liot\u00e9 F, Smail A, Limal N, Perard L, Desmurs-Clavel H, Le Thi HD, Asli B, Kahn JE, Pourrat J, Sailler L, Ackermann F, Papo T, Sacr\u00e9 K, Fain O, Stirnemann J, Cacoub P, Leroux G, Cohen-Bittan J, Sellam J, Mariette X, Blanchet B, Hulot JS, Amoura Z, Piette JC, Costedoat-Chalumeau N (2015a) Determinants of hydroxychloroquine blood concentration variations in systemic lupus erythematosus. Arthritis Rheumatol 67(8):2176\u20132184. https:\/\/doi.org\/10.1002\/art.39194","journal-title":"Arthritis Rheumatol"},{"key":"887_CR13","doi-asserted-by":"publisher","first-page":"2176","DOI":"10.1002\/art.39194","volume":"67","author":"M Jallouli","year":"2015","unstructured":"Jallouli M, Galicier L, Zahr N, Auma\u00eetre O, Franc\u00e8s C, Le Guern V, Liot\u00e9 F, Smail A, Limal N, Perard L, Desmurs-Clavel H, Le Thi HD, Asli B, Kahn JE, Pourrat J, Sailler L, Ackermann F, Papo T, Sacr\u00e9 K, Fain O, Stirnemann J, Cacoub P, Leroux G, Cohen-Bittan J, Sellam J, Mariette X, Blanchet B, Hulot JS, Amoura Z, Piette JC, Costedoat-Chalumeau N, Plaquenil Lupus Systemic Study G (2015b) Determinants of hydroxychloroquine blood concentration variations in systemic lupus erythematosus. Arthritis Rheumatol 67:2176\u20132184. https:\/\/doi.org\/10.1002\/art.39194","journal-title":"Arthritis Rheumatol"},{"issue":"1","key":"887_CR14","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1208\/s12248-014-9685-5","volume":"17","author":"R Jenkins","year":"2015","unstructured":"Jenkins R, Duggan JX, Aubry AF, Zeng J, Lee JW, Cojocaru L, Dufield D, Garofolo F, Kaur S, Schultz GA, Xu K, Yang Z, Yu J, Zhang YJ, Vazvaei F (2015) Recommendations for validation of LC-MS\/MS bioanalytical methods for protein biotherapeutics. AAPS J 17(1):1\u201316. https:\/\/doi.org\/10.1208\/s12248-014-9685-5","journal-title":"AAPS J"},{"issue":"17","key":"887_CR15","doi-asserted-by":"publisher","first-page":"E450","DOI":"10.1503\/cmaj.200528","volume":"192","author":"DN Juurlink","year":"2020","unstructured":"Juurlink DN (2020) Safety considerations with chloroquine, hydroxychloroquine and azithromycin in the management of SARS-CoV-2 infection. Can Med Assoc J 192(17):E450. https:\/\/doi.org\/10.1503\/cmaj.200528","journal-title":"Can Med Assoc J"},{"key":"887_CR16","doi-asserted-by":"publisher","DOI":"10.1101\/2020.07.30.20165365","author":"SM Kamran","year":"2020","unstructured":"Kamran SM, Z-e-H M, Naseem A, Azam R, Ullah N, Saeed F, Alamgir W, Saleem S, Nisar S, Hussain M (2020) Clearing the fog: is hydroxychloroquine effective in reducing corona virus disease-2019 progression: a randomized controlled trial. MedRxiv. https:\/\/doi.org\/10.1101\/2020.07.30.20165365","journal-title":"MedRxiv"},{"issue":"7","key":"887_CR17","doi-asserted-by":"publisher","first-page":"600","DOI":"10.1093\/chromsci\/bmaa023","volume":"58","author":"X Luo","year":"2020","unstructured":"Luo X, Peng Y, Ge W (2020) A sensitive and optimized HPLC-FLD method for the simultaneous quantification of hydroxychloroquine and its two metabolites in blood of systemic lupus erythematosus patients. J Chromatogr Sci 58(7):600\u2013605. https:\/\/doi.org\/10.1093\/chromsci\/bmaa023","journal-title":"J Chromatogr Sci"},{"key":"887_CR18","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.635371","author":"MA Martinez","year":"2021","unstructured":"Martinez MA (2021) Lack of effectiveness of repurposed drugs for covid-19 treatment. Front Immunol. https:\/\/doi.org\/10.3389\/fimmu.2021.635371","journal-title":"Front Immunol"},{"issue":"9","key":"887_CR19","doi-asserted-by":"publisher","first-page":"1036","DOI":"10.1001\/jamacardio.2020.1834","volume":"5","author":"NJ Mercuro","year":"2020","unstructured":"Mercuro NJ, Yen CF, Shim DJ, Maher TR, McCoy CM, Zimetbaum PJ, Gold HS (2020) Risk of QT interval prolongation associated with use of hydroxychloroquine with or without concomitant azithromycin among hospitalized patients testing positive for coronavirus disease 2019 (COVID-19). JAMA Cardiol 5(9):1036\u20131041. https:\/\/doi.org\/10.1001\/jamacardio.2020.1834","journal-title":"JAMA Cardiol"},{"issue":"4","key":"887_CR20","doi-asserted-by":"publisher","first-page":"530","DOI":"10.1002\/acr.20393","volume":"63","author":"SJ Morris","year":"2011","unstructured":"Morris SJ, Wasko MC, Antohe JL, Sartorius JA, Kirchner HL, Dancea S, Bili A (2011) Hydroxychloroquine use associated with improvement in lipid profiles in rheumatoid arthritis patients. Arthritis Care Res (hoboken) 63(4):530\u2013534. https:\/\/doi.org\/10.1002\/acr.20393","journal-title":"Arthritis Care Res (hoboken)"},{"key":"887_CR21","doi-asserted-by":"publisher","DOI":"10.1007\/s40121-020-00325-2","author":"T Morrisette","year":"2020","unstructured":"Morrisette T, Lodise T, Scheetz M, Goswami S, Pogue J, Rybak M (2020) The pharmacokinetic and pharmacodynamic properties of hydroxychloroquine and dose selection for COVID-19: putting the cart before the horse. Infect Dis Ther. https:\/\/doi.org\/10.1007\/s40121-020-00325-2","journal-title":"Infect Dis Ther"},{"issue":"6","key":"887_CR22","doi-asserted-by":"publisher","first-page":"1460","DOI":"10.1002\/art.10307","volume":"46","author":"T Munster","year":"2002","unstructured":"Munster T, Gibbs JP, Shen D, Baethge BA, Botstein GR, Caldwell J, Dietz F, Ettlinger R, Golden HE, Lindsley H, McLaughlin GE, Moreland LW, Roberts WN, Rooney TW, Rothschild B, Sack M, Sebba AI, Weisman M, Welch KE, Yocum D, Furst DE (2002) Hydroxychloroquine concentration-response relationships in patients with rheumatoid arthritis. Arthritis Rheum 46(6):1460\u20131469. https:\/\/doi.org\/10.1002\/art.10307","journal-title":"Arthritis Rheum"},{"issue":"8","key":"887_CR23","doi-asserted-by":"publisher","DOI":"10.15252\/emmm.202012476","volume":"12","author":"EL Nirk","year":"2020","unstructured":"Nirk EL, Reggiori F, Mauthe M (2020) Hydroxychloroquine in rheumatic autoimmune disorders and beyond. EMBO Mol Med 12(8):e12476. https:\/\/doi.org\/10.15252\/emmm.202012476","journal-title":"EMBO Mol Med"},{"key":"887_CR24","doi-asserted-by":"publisher","first-page":"6","DOI":"10.36348\/sjm.2020.v05i01.002","volume":"05","author":"N Omri","year":"2020","unstructured":"Omri N, Mekouar F, Assoufi N, Maaroufi A, Charef A, Smaali J, Jira M, Fatihi J, Eljaoudi R (2020) Variation of hydroxychloroquine blood levels in moroccan patients with systemic lupus erythematosus; a pilot study. Saudi J Med 05:6\u201310. https:\/\/doi.org\/10.36348\/sjm.2020.v05i01.002","journal-title":"Saudi J Med"},{"issue":"8","key":"887_CR25","doi-asserted-by":"publisher","first-page":"2677","DOI":"10.1002\/art.34473","volume":"64","author":"M Petri","year":"2012","unstructured":"Petri M, Orbai AM, Alarc\u00f3n GS, Gordon C, Merrill JT, Fortin PR, Bruce IN, Isenberg D, Wallace DJ, Nived O, Sturfelt G, Ramsey-Goldman R, Bae SC, Hanly JG, S\u00e1nchez-Guerrero J, Clarke A, Aranow C, Manzi S, Urowitz M, Gladman D, Kalunian K, Costner M, Werth VP, Zoma A, Bernatsky S, Ruiz-Irastorza G, Khamashta MA, Jacobsen S, Buyon JP, Maddison P, Dooley MA, van Vollenhoven RF, Ginzler E, Stoll T, Peschken C, Jorizzo JL, Callen JP, Lim SS, Fessler BJ, Inanc M, Kamen DL, Rahman A, Steinsson K, Franks AG Jr, Sigler L, Hameed S, Fang H, Pham N, Brey R, Weisman MH, McGwin G Jr, Magder LS (2012) Derivation and validation of the systemic lupus international collaborating clinics classification criteria for systemic lupus erythematosus. Arthritis Rheum 64(8):2677\u20132686. https:\/\/doi.org\/10.1002\/art.34473","journal-title":"Arthritis Rheum"},{"issue":"6","key":"887_CR26","doi-asserted-by":"publisher","first-page":"830","DOI":"10.1002\/art.24538","volume":"61","author":"GJ Pons-Estel","year":"2009","unstructured":"Pons-Estel GJ, Alarc\u00f3n GS, McGwin G Jr, Danila MI, Zhang J, Bastian HM, Reveille JD, Vil\u00e1 LM (2009) Protective effect of hydroxychloroquine on renal damage in patients with lupus nephritis: LXV, data from a multiethnic US cohort. Arthritis Rheum 61(6):830\u2013839. https:\/\/doi.org\/10.1002\/art.24538","journal-title":"Arthritis Rheum"},{"key":"887_CR27","doi-asserted-by":"publisher","DOI":"10.4155\/fso.15.24","author":"Y Qu","year":"2015","unstructured":"Qu Y, Noe G, Breaud AR, Vidal M, Clarke WA, Zahr N, Dervieux T, Costedoat-Chalumeau N, Blanchet B (2015) Development and validation of a clinical HPLC method for the quantification of hydroxychloroquine and its metabolites in whole blood. Future Sci OA. https:\/\/doi.org\/10.4155\/fso.15.24","journal-title":"Future Sci OA"},{"issue":"1","key":"887_CR28","doi-asserted-by":"publisher","first-page":"9023","DOI":"10.1038\/s41598-021-88509-9","volume":"11","author":"\u00c1 R\u00e9a-Neto","year":"2021","unstructured":"R\u00e9a-Neto \u00c1, Bernardelli RS, C\u00e2mara BMD, Reese FB, Queiroga MVO, Oliveira MC (2021) An open-label randomized controlled trial evaluating the efficacy of chloroquine\/hydroxychloroquine in severe COVID-19 patients. Sci Rep 11(1):9023. https:\/\/doi.org\/10.1038\/s41598-021-88509-9","journal-title":"Sci Rep"},{"issue":"2","key":"887_CR29","doi-asserted-by":"publisher","first-page":"91","DOI":"10.5152\/eurjrheum.2015.0028","volume":"3","author":"E Sames","year":"2016","unstructured":"Sames E, Paterson H, Li C (2016) Hydroxychloroquine-induced agranulocytosis in a patient with long-term rheumatoid arthritis. Eur J Rheumatol 3(2):91\u201392. https:\/\/doi.org\/10.5152\/eurjrheum.2015.0028","journal-title":"Eur J Rheumatol"},{"issue":"5","key":"887_CR30","doi-asserted-by":"publisher","first-page":"6615","DOI":"10.18632\/oncotarget.23570","volume":"9","author":"M Shapiro","year":"2017","unstructured":"Shapiro M, Levy Y (2017) The association between hydroxychloroquine treatment and cardiovascular morbidity among rheumatoid arthritis patients. Oncotarget 9(5):6615\u20136622. https:\/\/doi.org\/10.18632\/oncotarget.23570","journal-title":"Oncotarget"},{"key":"887_CR31","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1002\/art.39859","volume":"69","author":"CH Shiboski","year":"2017","unstructured":"Shiboski CH, Shiboski SC, Seror R, Criswell LA, Labetoulle M, Lietman TM, Rasmussen A, Scofield H, Vitali C, Bowman SJ, Mariette X, International Sj\u00f6gren\u2019s Syndrome Criteria Working G (2017) 2016 American college of rheumatology\/european league against rheumatism classification criteria for primary Sj\u00f6gren\u2019s syndrome: a consensus and data-driven methodology involving three international patient cohorts. Arthritis Rheumatol 69:35\u201345. https:\/\/doi.org\/10.1002\/art.39859","journal-title":"Arthritis Rheumatol"},{"key":"887_CR32","doi-asserted-by":"publisher","first-page":"280","DOI":"10.1016\/j.cca.2020.06.017","volume":"509","author":"P Song","year":"2020","unstructured":"Song P, Li W, Xie J, Hou Y, You C (2020) Cytokine storm induced by SARS-CoV-2. Clin Chim Acta 509:280\u2013287. https:\/\/doi.org\/10.1016\/j.cca.2020.06.017","journal-title":"Clin Chim Acta"},{"issue":"9","key":"887_CR33","doi-asserted-by":"publisher","first-page":"968","DOI":"10.1111\/j.1445-5994.2012.02886.x","volume":"42","author":"C Tang","year":"2012","unstructured":"Tang C, Godfrey T, Stawell R, Nikpour M (2012) Hydroxychloroquine in lupus: emerging evidence supporting multiple beneficial effects. Intern Med J 42(9):968\u2013978. https:\/\/doi.org\/10.1111\/j.1445-5994.2012.02886.x","journal-title":"Intern Med J"},{"issue":"2","key":"887_CR34","doi-asserted-by":"publisher","first-page":"681","DOI":"10.1007\/s40744-021-00315-x","volume":"8","author":"W Tang","year":"2021","unstructured":"Tang W, Khalili L, Giles J, Gartshteyn Y, Kapoor T, Guo C, Chen T, Theodore D, Askanase A (2021) The rise and fall of hydroxychloroquine with the covid-19 pandemic: narrative review of selected data. Rheumatol Ther 8(2):681\u2013691. https:\/\/doi.org\/10.1007\/s40744-021-00315-x","journal-title":"Rheumatol Ther"},{"issue":"4","key":"887_CR35","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1136\/ard.58.4.253","volume":"58","author":"M Tishler","year":"1999","unstructured":"Tishler M, Yaron I, Shirazi I, Yaron M (1999) Hydroxychloroquine treatment for primary Sj\u00f6gren\u2019s syndrome: its effect on salivary and serum inflammatory markers. Ann Rheum Dis 58(4):253\u2013256. https:\/\/doi.org\/10.1136\/ard.58.4.253","journal-title":"Ann Rheum Dis"},{"issue":"11","key":"887_CR36","doi-asserted-by":"publisher","first-page":"1747","DOI":"10.1136\/annrheumdis-2013-204424","volume":"72","author":"F van den Hoogen","year":"2013","unstructured":"van den Hoogen F, Khanna D, Fransen J, Johnson SR, Baron M, Tyndall A, Matucci-Cerinic M, Naden RP, Medsger TA Jr, Carreira PE, Riemekasten G, Clements PJ, Denton CP, Distler O, Allanore Y, Furst DE, Gabrielli A, Mayes MD, van Laar JM, Seibold JR, Czirjak L, Steen VD, Inanc M, Kowal-Bielecka O, M\u00fcller-Ladner U, Valentini G, Veale DJ, Vonk MC, Walker UA, Chung L, Collier DH, Ellen Csuka M, Fessler BJ, Guiducci S, Herrick A, Hsu VM, Jimenez S, Kahaleh B, Merkel PA, Sierakowski S, Silver RM, Simms RW, Varga J, Pope JE (2013) 2013 classification criteria for systemic sclerosis: an American college of rheumatology\/European league against rheumatism collaborative initiative. Ann Rheum Dis 72(11):1747\u20131755. https:\/\/doi.org\/10.1136\/annrheumdis-2013-204424","journal-title":"Ann Rheum Dis"},{"key":"887_CR37","unstructured":"Wayne PA (2014) CLSI document C62-A Liquid Chromatography-Mass Spectrometry Methods; Approved Guidelines. Clinical and Laboratory Standards Institute, Pennsylvania"},{"issue":"9","key":"887_CR38","doi-asserted-by":"publisher","first-page":"e1003252","DOI":"10.1371\/journal.pmed.1003252","volume":"17","author":"NJ White","year":"2020","unstructured":"White NJ, Watson JA, Hoglund RM, Chan XHS, Cheah PY, Tarning J (2020) COVID-19 prevention and treatment: a critical analysis of chloroquine and hydroxychloroquine clinical pharmacology. PLoS Med 17(9):e1003252\u2013e1003252. https:\/\/doi.org\/10.1371\/journal.pmed.1003252","journal-title":"PLoS Med"},{"key":"887_CR42","unstructured":"Worldometer (2021) Coronavirus. https:\/\/www.worldometers.info\/coronavirus\/. Accessed 13 \u00a0Sept \u00a02021"},{"issue":"5","key":"887_CR39","doi-asserted-by":"publisher","first-page":"702","DOI":"10.2215\/CJN.11781017","volume":"13","author":"C-L Wu","year":"2018","unstructured":"Wu C-L, Chang C-C, Kor C-T, Yang T-H, Chiu P-F, Tarng D-C, Hsu C-C (2018) Hydroxychloroquine use and risk of CKD in patients with rheumatoid arthritis. Clin J Am Soc Nephrol CJASN 13(5):702\u2013709. https:\/\/doi.org\/10.2215\/CJN.11781017","journal-title":"Clin J Am Soc Nephrol CJASN"},{"key":"887_CR40","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2020-217728","author":"CY Wu","year":"2020","unstructured":"Wu CY, Tan M, Huang JY, Chiou JY, Wei JC (2020) Hydroxychloroquine is neutral in risk of chronic kidney disease in patients with systemic lupus erythematosus. Ann Rheum Dis. https:\/\/doi.org\/10.1136\/annrheumdis-2020-217728","journal-title":"Ann Rheum Dis"},{"issue":"10","key":"887_CR41","doi-asserted-by":"publisher","first-page":"161","DOI":"10.3390\/cells7100161","volume":"7","author":"H-Y Yap","year":"2018","unstructured":"Yap H-Y, Tee SZ-Y, Wong MM-T, Chow S-K, Peh S-C, Teow S-Y (2018) Pathogenic role of immune cells in rheumatoid arthritis: implications in clinical treatment and biomarker development. Cells 7(10):161. https:\/\/doi.org\/10.3390\/cells7100161","journal-title":"Cells"}],"container-title":["Inflammopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10787-021-00887-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10787-021-00887-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10787-021-00887-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,8]],"date-time":"2025-04-08T23:13:44Z","timestamp":1744154024000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10787-021-00887-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11,7]]},"references-count":42,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["887"],"URL":"https:\/\/doi.org\/10.1007\/s10787-021-00887-8","relation":{},"ISSN":["0925-4692","1568-5608"],"issn-type":[{"value":"0925-4692","type":"print"},{"value":"1568-5608","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,11,7]]},"assertion":[{"value":"4 October 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 October 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 November 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that they have no conflict of interest relevant to the content of this manuscript.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The study was approved by the Selcuk University local Ethics Committee (Number: 2020\/420, Date: 30\/09\/2020).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Informed consent of all patients was obtained.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}}]}}