{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T03:56:27Z","timestamp":1782273387740,"version":"3.54.5"},"reference-count":42,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,11,30]],"date-time":"2021-11-30T00:00:00Z","timestamp":1638230400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,11,30]],"date-time":"2021-11-30T00:00:00Z","timestamp":1638230400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100004901","name":"funda\u00e7\u00e3o de amparo \u00e0 pesquisa do estado de minas gerais","doi-asserted-by":"publisher","award":["FAPEMIG; APQ-03120-16"],"award-info":[{"award-number":["FAPEMIG; APQ-03120-16"]}],"id":[{"id":"10.13039\/501100004901","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"conselho nacional de desenvolvimento cient\u00edfico e tecnol\u00f3gico","doi-asserted-by":"publisher","award":["CNPq; 303307\/2018-8"],"award-info":[{"award-number":["CNPq; 303307\/2018-8"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"name":"coordena\u00e7\u00e3o de aperfei\u00e7oamento de pessoal de ensino superior","award":["CAPES; Finance Code 001"],"award-info":[{"award-number":["CAPES; Finance Code 001"]}]},{"DOI":"10.13039\/501100007375","name":"pr\u00f3-reitoria de pesquisa, universidade federal de minas gerais","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007375","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Inflammopharmacol"],"published-print":{"date-parts":[[2022,2]]},"DOI":"10.1007\/s10787-021-00899-4","type":"journal-article","created":{"date-parts":[[2021,11,30]],"date-time":"2021-11-30T20:53:41Z","timestamp":1638305621000},"page":"233-241","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Metformin effect in models of inflammation is associated with activation of ATP-dependent potassium channels and inhibition of tumor necrosis factor-\u03b1 production"],"prefix":"10.1007","volume":"30","author":[{"given":"Paulo S. A.","family":"Augusto","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamires C.","family":"Matsui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alysson V.","family":"Braga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felipe F.","family":"Rodrigues","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcela I.","family":"Morais","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcela M. G. B.","family":"Dutra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carla R. A.","family":"Batista","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivo S. F.","family":"Melo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah O. A. M.","family":"Costa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caryne M.","family":"Bertollo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00e1rcio M.","family":"Coelho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1284-1195","authenticated-orcid":false,"given":"Renes R.","family":"Machado","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,11,30]]},"reference":[{"key":"899_CR1","doi-asserted-by":"publisher","first-page":"1032","DOI":"10.1038\/s41393-018-0168-x","volume":"56","author":"K Afshari","year":"2018","unstructured":"Afshari K, Dehdashtian A, Haddadi NS, Haj-Mirzaian A, Iranmehr A, Ebrahimi MA, Tavangar SM, Faghir-Ghanesefat H, Mohammadi F, Rahimi N, Javidan AN, Dehpour AR (2018) Anti-inflammatory effects of metformin improve the neuropathic pain and locomotor activity in spinal cord injured rats: introduction of an alternative therapy. Spinal Cord 56:1032\u20131041. https:\/\/doi.org\/10.1038\/s41393-018-0168-x","journal-title":"Spinal Cord"},{"key":"899_CR2","doi-asserted-by":"publisher","first-page":"185","DOI":"10.3945\/jn.113.183657","volume":"144","author":"M Allegra","year":"2014","unstructured":"Allegra M, Ianaro A, Tersigni M, Panza E, Tesoriere L, Livrea MA (2014) Indicaxanthin from cactus pear fruit exerts anti-inflammatory effects in carrageenin-induced rat pleurisy. J Nutr 144:185\u2013192. https:\/\/doi.org\/10.3945\/jn.113.183657","journal-title":"J Nutr"},{"key":"899_CR3","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2019.172497","volume":"858","author":"PSA Augusto","year":"2019","unstructured":"Augusto PSA, Braga AV, Rodrigues FF, Morais MI, Dutra MMGB, Batista CRA, Melo ISF, Costa SOAM, Goulart FA, Coelho MM, Machado RR (2019) Metformin antinociceptive effect in models of nociceptive and neuropathic pain is partially mediated by activation of opioidergic mechanisms. Eur J Pharmacol 858:172497. https:\/\/doi.org\/10.1016\/j.ejphar.2019.172497","journal-title":"Eur J Pharmacol"},{"key":"899_CR4","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1002\/pdi.606","volume":"21","author":"CJ Bailey","year":"2004","unstructured":"Bailey CJ, Day C (2004) Metformin: its botanical background. Pract Diab Int 21:115\u2013117. https:\/\/doi.org\/10.1002\/pdi.606","journal-title":"Pract Diab Int"},{"key":"899_CR5","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1152\/ajpgi.00329.2014","volume":"309","author":"M Cahova","year":"2015","unstructured":"Cahova M, Palenickova E, Dankova H, Sticova E, Burian M, Drahota Z, Cervinkova Z, Kucera O, Gladkova C, Stopka P, Krizova J, Papackova Z, Oliyarnyk O, Kazdova L (2015) Metformin prevents ischemia reperfusion-induced oxidative stress in the fatty liver by attenuation of reactive oxygen species formation. Am J Physiol Gastrointest Liver Physiol 309:100\u2013111. https:\/\/doi.org\/10.1152\/ajpgi.00329.2014","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"899_CR6","doi-asserted-by":"publisher","first-page":"262","DOI":"10.1152\/ajplung.00389.2014","volume":"309","author":"X Chen","year":"2015","unstructured":"Chen X, Walther FJ, Sengers RM, Laghmani EH, Salam A, Folkerts G, Pera T, Wagenaar GT (2015) Metformin attenuates hyperoxia-induced lung injury in neonatal rats by reducing the inflammatory response. Am J Physiol Lung Cell Mol Physiol 309:262\u2013270. https:\/\/doi.org\/10.1152\/ajplung.00389.2014","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"899_CR7","first-page":"50","volume-title":"Robbins Pathologic basis of disease","author":"T Collins","year":"1999","unstructured":"Collins T (1999) Acute and chronic inflammation. In: Cotran RS, Kumar V, Collins T (eds) Robbins Pathologic basis of disease, 6th edn. Saunders, Philadelphia, pp 50\u201388","edition":"6"},{"key":"899_CR8","doi-asserted-by":"publisher","first-page":"240","DOI":"10.1016\/j.it.2017.12.003","volume":"39","author":"AD Cook","year":"2018","unstructured":"Cook AD, Christensen AD, Tewari D, McMahon SB, Hamilton JA (2018) Immune cytokines and their receptors in inflammatory pain. Trends Immunol 39:240\u2013255. https:\/\/doi.org\/10.1016\/j.it.2017.12.003","journal-title":"Trends Immunol"},{"key":"899_CR9","doi-asserted-by":"publisher","first-page":"392","DOI":"10.1111\/j.1475381.1971.tb07124.x","volume":"42","author":"P Crunkhorn","year":"1971","unstructured":"Crunkhorn P, Meacock SC (1971) Mediators of the inflammation induced in the rat paw by carrageenin. Br J Pharmacol 42:392\u2013402. https:\/\/doi.org\/10.1111\/j.1475381.1971.tb07124.x","journal-title":"Br J Pharmacol"},{"key":"899_CR10","doi-asserted-by":"publisher","first-page":"4930","DOI":"10.1182\/blood-2013-02-486217","volume":"121","author":"K De Filippo","year":"2013","unstructured":"De Filippo K, Dudeck A, Hasenberg M, Nye E, Van Rooijen N, Hartmann K, Gunzer M, Roers A, Hogg N (2013) Mast cell and macrophage chemokines CXCL1\/CXCL2 control the early stage of neutrophil recruitment during tissue inflammation. Blood 121:4930\u20134937. https:\/\/doi.org\/10.1182\/blood-2013-02-486217","journal-title":"Blood"},{"key":"899_CR11","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1111\/j.2042-7158.1972.tb08940.x","volume":"24","author":"M Di Rosa","year":"1972","unstructured":"Di Rosa M (1972) Biological properties of carrageenan. J Pharm Pharmacol 24:89\u2013102. https:\/\/doi.org\/10.1111\/j.2042-7158.1972.tb08940.x","journal-title":"J Pharm Pharmacol"},{"key":"899_CR12","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1006\/cyto.2000.0816","volume":"13","author":"TS Fr\u00f6de","year":"2001","unstructured":"Fr\u00f6de TS, Souza GE, Calixto JB (2001) The modulatory role played by TNF-alpha and IL-1 beta in the inflammatory responses induced by carrageenan in the mouse model of pleurisy. Cytokine 13:162\u2013168. https:\/\/doi.org\/10.1006\/cyto.2000.0816","journal-title":"Cytokine"},{"key":"899_CR13","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1006\/cyto.2001.0980","volume":"17","author":"TS Fr\u00f6de","year":"2002","unstructured":"Fr\u00f6de TS, Souza GE, Calixto JB (2002) The effects of IL-6 and IL-10 and their specific antibodies in the acute inflammatory responses induced by carrageenan in the mouse model of pleurisy. Cytokine 17:149\u2013156. https:\/\/doi.org\/10.1006\/cyto.2001.0980","journal-title":"Cytokine"},{"key":"899_CR14","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1080\/10739680802355897","volume":"16","author":"FS Gaskin","year":"2009","unstructured":"Gaskin FS, Kamada K, Yusof M, Durante W, Gross G, Korthuis RJ (2009) AICAR preconditioning prevents postischemic leukocyte rolling and adhesion: role of K(ATP) channels and hemeoxygenase. Microcirculation 16:167\u2013176. https:\/\/doi.org\/10.1080\/10739680802355897","journal-title":"Microcirculation"},{"key":"899_CR15","doi-asserted-by":"publisher","first-page":"10252","DOI":"10.18632\/aging.102453","volume":"11","author":"Y Han","year":"2019","unstructured":"Han Y, Yuan F, Deng C, He F, Zhang Y, Shen H, Chen Z, Qian L (2019) Metformin decreases LPS-induced inflammatory response in rabbit annulus fibrosus stem\/progenitor cells by blocking HMGB1 release. Aging 11:10252\u201310265. https:\/\/doi.org\/10.18632\/aging.102453","journal-title":"Aging"},{"key":"899_CR16","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1007\/s10787-016-0275-2","volume":"24","author":"A Hasanvand","year":"2016","unstructured":"Hasanvand A, Amini-Khoei H, Hadian MR, Abdollahi A, Tavangar SM, Dehpour AR, Semiei E, Mehr SE (2016) Anti-inflammatory effect of AMPK signaling pathway in rat model of diabetic neuropathy. Inflammopharmacology 24:207\u2013219. https:\/\/doi.org\/10.1007\/s10787-016-0275-2","journal-title":"Inflammopharmacology"},{"key":"899_CR17","doi-asserted-by":"publisher","first-page":"972","DOI":"10.1073\/pnas.1221055110","volume":"110","author":"HA Hirsch","year":"2013","unstructured":"Hirsch HA, Iliopulos D, Struhl K (2013) Metformin inhibits the inflammatory response associated with cellular transformation and cancer stem cell growth. Proc Natl Acad Sci USA 110:972\u2013977. https:\/\/doi.org\/10.1073\/pnas.1221055110","journal-title":"Proc Natl Acad Sci USA"},{"key":"899_CR18","doi-asserted-by":"publisher","first-page":"18132","DOI":"10.1073\/pnas.1106201108","volume":"108","author":"N Ikematsu","year":"2011","unstructured":"Ikematsu N, Dallas ML, Ross FA, Lewis RW, Rafferty JN, David JA, Suman R, Peers C, Hardie DG, Evans AM (2011) Phosphorylation of the voltage-gated potassium channel Kv2.1 by AMP-activated protein kinase regulates membrane excitability. Proc Natl Acad Sci USA 108:18132\u201318137. https:\/\/doi.org\/10.1073\/pnas.1106201108","journal-title":"Proc Natl Acad Sci USA"},{"key":"899_CR19","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1016\/j.intimp.2013.03.020","volume":"16","author":"KY Kang","year":"2013","unstructured":"Kang KY, Kim YK, Yi H, Kim J, Jung HR, Kim IJ, Cho JH, Park SH, Kim HY, Ju JH (2013) Metformin downregulates Th17 cells differentiation and attenuates murine autoimmune arthritis. Int Immunopharmacol 16:85\u201392. https:\/\/doi.org\/10.1016\/j.intimp.2013.03.020","journal-title":"Int Immunopharmacol"},{"key":"899_CR20","doi-asserted-by":"publisher","first-page":"632","DOI":"10.1055\/s-0030-1255033","volume":"42","author":"Y Kato","year":"2010","unstructured":"Kato Y, Koide N, Komatsu T, Tumurkhuu G, Dagvadorj J, Kato K, Yokochi T (2010) Metformin attenuates production of nitric oxide in response to lipopolysaccharide by inhibiting MyD88-independent pathway. Horm Metab Res 42:632\u2013636. https:\/\/doi.org\/10.1055\/s-0030-1255033","journal-title":"Horm Metab Res"},{"key":"899_CR21","doi-asserted-by":"publisher","first-page":"524","DOI":"10.4049\/jimmunol.167.1.524","volume":"167","author":"A Klein","year":"2001","unstructured":"Klein A, Talvani A, Silva PM, Martins MA, Wells TN, Proudfoot A, Luckacs NW, Teixeira MM (2001) Stem cell factor-induced leukotriene B4 production cooperates with eotaxin to mediate the recruitment of eosinophils during allergic pleurisy in mice. J Immunol 167:524\u2013531. https:\/\/doi.org\/10.4049\/jimmunol.167.1.524","journal-title":"J Immunol"},{"key":"899_CR22","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0135858","volume":"10","author":"SY Lee","year":"2015","unstructured":"Lee SY, Lee SH, Yang EJ, Kim EK, Kim JK, Shin DY, Cho ML (2015) Metformin ameliorates inflammatory bowel disease by suppression of the stat3 signaling pathway and regulation of the between th17\/Treg balance. PLoS ONE 10:e0135858. https:\/\/doi.org\/10.1371\/journal.pone.0135858","journal-title":"PLoS ONE"},{"key":"899_CR23","doi-asserted-by":"publisher","first-page":"446","DOI":"10.1007\/s00380-008-1137-7","volume":"24","author":"SN Li","year":"2009","unstructured":"Li SN, Wang X, Zeng QT, Feng YB, Cheng X, Mao XB, Wang TH, Deng HP (2009) Metformin inhibits nuclear factor kappa B activation and decreases serum high-sensitivity C-reactive protein level in experimental atherogenesis of rabbits. Heart Vessels 24:446\u2013453. https:\/\/doi.org\/10.1007\/s00380-008-1137-7","journal-title":"Heart Vessels"},{"key":"899_CR24","doi-asserted-by":"publisher","first-page":"1117","DOI":"10.1007\/s00011-012-0504-0","volume":"61","author":"C Luchese","year":"2012","unstructured":"Luchese C, Prigol M, Duarte MM, Nogueira CW (2012) Diphenyl diselenide reduces inflammation in the mouse model of pleurisy induced by carrageenan: reduction of pro-inflammatory markers and reactive species levels. Inflamm Res 61:1117\u20131124. https:\/\/doi.org\/10.1007\/s00011-012-0504-0","journal-title":"Inflamm Res"},{"key":"899_CR25","doi-asserted-by":"publisher","first-page":"292","DOI":"10.4103\/0253-7613.157127","volume":"47","author":"MT Mansouri","year":"2015","unstructured":"Mansouri MT, Hemmati AA, Naghizadeh B, Mard SA, Rezaie A, Ghorbanzadeh B (2015) A study of the mechanisms underlying the anti-inflammatory effect of ellagic acid in carrageenan-induced paw edema in rats. Indian J Pharmacol 47:292\u2013298. https:\/\/doi.org\/10.4103\/0253-7613.157127","journal-title":"Indian J Pharmacol"},{"key":"899_CR26","doi-asserted-by":"publisher","first-page":"306","DOI":"10.1016\/j.ejphar.2015.11.034","volume":"769","author":"TC Matsui","year":"2015","unstructured":"Matsui TC, Coura GME, Melo ISF, Batista CRA, Augusto PSA, Godin AM, Ara\u00fajo DP, C\u00e9sar IC, Ribeiro LS, Souza DGS, Klein A, F\u00e1tima A, Machado RR, Coelho MM (2015) Nicorandil inhibits neutrophil recruitment in carrageenan-induced experimental pleurisy in mice. Eur J Pharmacol 769:306\u2013312. https:\/\/doi.org\/10.1016\/j.ejphar.2015.11.034","journal-title":"Eur J Pharmacol"},{"key":"899_CR27","doi-asserted-by":"publisher","first-page":"1660","DOI":"10.1016\/j.bcp.2012.09.025","volume":"84","author":"CS Park","year":"2012","unstructured":"Park CS, Bang BR, Kwon HS, Moon KA, Kim TB, Lee KY, Moon HB, Cho YS (2012) Metformin reduces airway inflammation and remodeling via activation of AMP-activated protein kinase. Biochem Pharmacol 84:1660\u20131670. https:\/\/doi.org\/10.1016\/j.bcp.2012.09.025","journal-title":"Biochem Pharmacol"},{"key":"899_CR28","doi-asserted-by":"publisher","first-page":"387","DOI":"10.2119\/molmed.2013.00065","volume":"8","author":"DW Park","year":"2013","unstructured":"Park DW, Jiang S, Tadie JM, Stigler WS, Gao Y, Deshane J, Abraham E, Zmijewski JW (2013) Activation of AMPK enhances neutrophil chemotaxis and bacterial killing. Mol Med 8:387\u2013398. https:\/\/doi.org\/10.2119\/molmed.2013.00065","journal-title":"Mol Med"},{"key":"899_CR29","doi-asserted-by":"publisher","first-page":"1317","DOI":"10.1213\/ANE.0000000000001561","volume":"124","author":"UB Pecikoza","year":"2017","unstructured":"Pecikoza UB, Tomi\u0107 MA, Micov AM, Stepanovi\u0107-Petrovi\u0107 RM (2017) Metformin synergizes with conventional and adjuvant analgesic drugs to reduce inflammatory hyperalgesia in rats. Anesth Analg 124:1317\u20131329. https:\/\/doi.org\/10.1213\/ANE.0000000000001561","journal-title":"Anesth Analg"},{"key":"899_CR30","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1038\/sj.bjp.0705650","volume":"142","author":"I Posadas","year":"2004","unstructured":"Posadas I, Bucci M, Roviezzo F, Rossi A, Parente L, Sautebin L, Cirino G (2004) Carrageenan-induced mouse paw edema is biphasic, age-weight dependent and displays differential nitric oxide cyclooxygenase-2 expression. Br J Pharmacol 142:331\u2013338. https:\/\/doi.org\/10.1038\/sj.bjp.0705650","journal-title":"Br J Pharmacol"},{"key":"899_CR31","doi-asserted-by":"publisher","first-page":"2843","DOI":"10.3892\/mmr.2016.4821","volume":"13","author":"M Rameshrad","year":"2016","unstructured":"Rameshrad M, Soraya H, Maleki-Dizaji N, Vaez H, Garjani A (2016) A-769662, a direct AMPK activator, attenuates lipopolysaccharide-induced acute heart and lung inflammation in rats. Mol Med Rep 13:2843\u20132849. https:\/\/doi.org\/10.3892\/mmr.2016.4821","journal-title":"Mol Med Rep"},{"key":"899_CR32","doi-asserted-by":"publisher","first-page":"1330","DOI":"10.1016\/j.jpain.2013.05.012","volume":"14","author":"OQ Russe","year":"2013","unstructured":"Russe OQ, M\u00f6ser CV, Kynast KL, King TS, Stephan H, Geisslinger G, Niederberger E (2013) Activation of the AMP-activated protein kinase reduces inflammatory nociception. J Pain 14:1330\u20131340. https:\/\/doi.org\/10.1016\/j.jpain.2013.05.012","journal-title":"J Pain"},{"key":"899_CR33","doi-asserted-by":"publisher","first-page":"196","DOI":"10.2174\/1871530315666150316124019","volume":"15","author":"Y Saisho","year":"2015","unstructured":"Saisho Y (2015) Metformin and inflammation: its potential beyond glucose-lowering effect. Endocr Metab Immune Disor Drug Targets 15:196\u2013205. https:\/\/doi.org\/10.2174\/1871530315666150316124019","journal-title":"Endocr Metab Immune Disor Drug Targets"},{"key":"899_CR34","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1016\/j.neuroscience.2014.05.031","volume":"274","author":"KZ Shen","year":"2014","unstructured":"Shen KZ, Yakhnitsa V, Munhall AC, Johnson SW (2014) AMP kinase regulates K-ATP currents evoked by NMDA receptor stimulation in rat subthalamic nucleus neurons. Neuroscience 274:138\u2013152. https:\/\/doi.org\/10.1016\/j.neuroscience.2014.05.031","journal-title":"Neuroscience"},{"key":"899_CR35","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1016\/j.bpa.2003.12.002","volume":"18","author":"ER Sherwood","year":"2004","unstructured":"Sherwood ER, Toliver-Kinsky T (2004) Mechanisms of the inflammatory response. Best Pract Res Clin Anaesthesiol 18:385\u2013405. https:\/\/doi.org\/10.1016\/j.bpa.2003.12.002","journal-title":"Best Pract Res Clin Anaesthesiol"},{"key":"899_CR36","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1016\/j.nbd.2017.06.001","volume":"105","author":"RL Silva","year":"2017","unstructured":"Silva RL, Lopes AH, Guimar\u00e3es RM, Cunha TM (2017) CXCL1\/CXCR2 signaling in pathological pain: role in peripheral and central sensitization. Neurobiol Dis 105:109\u2013116. https:\/\/doi.org\/10.1016\/j.nbd.2017.06.001","journal-title":"Neurobiol Dis"},{"key":"899_CR37","doi-asserted-by":"publisher","first-page":"2028","DOI":"10.2337\/db14-1225","volume":"64","author":"SB Vasamsetti","year":"2015","unstructured":"Vasamsetti SB, Karnewar S, Kanugula AK, Thatipalli AR, Kumar JM, Kotamjaru S (2015) Metformin inhibits monocyte-to-macrophage differentiation via AMPK-mediated inhibition of STAT3 activation: potential role in atherosclerosis. Diabetes 64:2028\u20132041. https:\/\/doi.org\/10.2337\/db14-1225","journal-title":"Diabetes"},{"key":"899_CR38","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1159\/000087655","volume":"14","author":"J Wieseler-Frank","year":"2005","unstructured":"Wieseler-Frank J, Maier SF, Watkins LR (2005) Central proinflammatory cytokines and pain enhancement. Neurosignals 14:166\u2013174. https:\/\/doi.org\/10.1159\/000087655","journal-title":"Neurosignals"},{"key":"899_CR39","doi-asserted-by":"publisher","first-page":"1105","DOI":"10.1172\/JCI14178","volume":"108","author":"LA Witters","year":"2001","unstructured":"Witters LA (2001) The blooming of the French lilac. J Clin Invest 108:1105\u20131107. https:\/\/doi.org\/10.1172\/JCI14178","journal-title":"J Clin Invest"},{"key":"899_CR40","doi-asserted-by":"publisher","first-page":"682","DOI":"10.1016\/j.intimp.2012.01.015","volume":"12","author":"H Yuan","year":"2012","unstructured":"Yuan H, Li L, Zheng W, Wan J, Ge P, Li H, Zhang L (2012) Antidiabetic drug metformin alleviates endotoxin-induced fulminant liver injury in mice. Int Immunopharmacol 12:682\u2013688. https:\/\/doi.org\/10.1016\/j.intimp.2012.01.015","journal-title":"Int Immunopharmacol"},{"key":"899_CR41","doi-asserted-by":"publisher","first-page":"1167","DOI":"10.1172\/JCI13505","volume":"108","author":"G Zhou","year":"2001","unstructured":"Zhou G, Myers R, Li Y, Chen Y, Shen X, Fenyk-Melody J, Wu M, Ventre J, Doebber T, Fujii N, Musi N, Hirshman MF, Goodyear LJ, Moller DE (2001) Role of AMP- activated protein kinase in mechanism of metformin action. J Clin Invest 108:1167\u20131174. https:\/\/doi.org\/10.1172\/JCI13505","journal-title":"J Clin Invest"},{"key":"899_CR42","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1016\/0304-3959(83)90201-4","volume":"16","author":"M Zimmermann","year":"1983","unstructured":"Zimmermann M (1983) Ethical guidelines for investigations of experimental pain in conscious animals. Pain 16:109\u2013110. https:\/\/doi.org\/10.1016\/0304-3959(83)90201-4","journal-title":"Pain"}],"container-title":["Inflammopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10787-021-00899-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10787-021-00899-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10787-021-00899-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,11]],"date-time":"2022-03-11T11:22:31Z","timestamp":1646997751000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10787-021-00899-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11,30]]},"references-count":42,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,2]]}},"alternative-id":["899"],"URL":"https:\/\/doi.org\/10.1007\/s10787-021-00899-4","relation":{},"ISSN":["0925-4692","1568-5608"],"issn-type":[{"value":"0925-4692","type":"print"},{"value":"1568-5608","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,11,30]]},"assertion":[{"value":"12 July 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 November 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 November 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that they have no conflicts of interest to disclose.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}