{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T06:20:52Z","timestamp":1791440452903,"version":"4.3.3"},"reference-count":39,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2022,3,28]],"date-time":"2022-03-28T00:00:00Z","timestamp":1648425600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2022,3,28]],"date-time":"2022-03-28T00:00:00Z","timestamp":1648425600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Inflammopharmacol"],"published-print":{"date-parts":[[2022,6]]},"DOI":"10.1007\/s10787-022-00972-6","type":"journal-article","created":{"date-parts":[[2022,3,28]],"date-time":"2022-03-28T18:10:03Z","timestamp":1648491003000},"page":"1037-1045","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Role of triggering receptor expressed on myeloid cells-1 (TREM-1) in COVID-19 and other viral pneumonias: a systematic review and meta-analysis of clinical studies"],"prefix":"10.1007","volume":"30","author":[{"given":"Yrna Lorena Matos","family":"de Oliveira","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayane","family":"de S\u00e1 Resende","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8779-0727","authenticated-orcid":false,"given":"Paulo Ricardo","family":"Martins-Filho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatiana Rodrigues","family":"de Moura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,3,28]]},"reference":[{"key":"972_CR1","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1007\/978-81-322-2680-2_4","volume-title":"Biology of C reactive protein in health and disease","author":"W Ansar","year":"2016","unstructured":"Ansar W, Ghosh S (2016) Inflammation and inflammatory diseases, markers, and mediators: role of CRP in some inflammatory diseases. Biology of C reactive protein in health and disease. Springer India, New Delhi, pp 67\u2013107. https:\/\/doi.org\/10.1007\/978-81-322-2680-2_4"},{"key":"972_CR2","doi-asserted-by":"publisher","first-page":"651","DOI":"10.1016\/j.arcmed.2015.12.003","volume":"46","author":"L Arriaga-Pizano","year":"2015","unstructured":"Arriaga-Pizano L, Ferat-Osorio E, Rodr\u00edguez-Abrego G et al (2015) Differential immune profiles in two pandemic influenza A(H1N1)pdm09 virus waves at pandemic epicenter. Arch Med Res 46:651\u2013658. https:\/\/doi.org\/10.1016\/j.arcmed.2015.12.003","journal-title":"Arch Med Res"},{"key":"972_CR3","doi-asserted-by":"publisher","first-page":"571","DOI":"10.1007\/s00011-018-1149-4","volume":"67","author":"I Bellos","year":"2018","unstructured":"Bellos I, Fitrou G, Daskalakis G et al (2018) Soluble TREM-1 as a predictive factor of neonatal sepsis: a meta-analysis. Inflamm Res 67:571\u2013578. https:\/\/doi.org\/10.1007\/s00011-018-1149-4","journal-title":"Inflamm Res"},{"key":"972_CR4","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2017.02265","author":"LGS Bomfim","year":"2017","unstructured":"Bomfim LGS, Magalh\u00e3es LS, Santos-Filho MAA et al (2017) Leishmania infantum induces the release of sTREM-1 in visceral leishmaniasis. Front Microb. https:\/\/doi.org\/10.3389\/fmicb.2017.02265","journal-title":"Front Microb"},{"key":"972_CR5","doi-asserted-by":"publisher","first-page":"4991","DOI":"10.4049\/jimmunol.164.10.4991","volume":"164","author":"A Bouchon","year":"2000","unstructured":"Bouchon A, Dietrich J, Colonna M (2000) Cutting edge: inflammatory responses can be triggered by TREM-1, a novel receptor expressed on neutrophils and monocytes. J Immunol 164:4991\u20134995. https:\/\/doi.org\/10.4049\/jimmunol.164.10.4991","journal-title":"J Immunol"},{"key":"972_CR6","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1016\/j.socscimed.2017.04.051","volume":"199","author":"CG Colen","year":"2018","unstructured":"Colen CG, Ramey DM, Cooksey EC, Williams DR (2018) Racial disparities in health among nonpoor African Americans and Hispanics: the role of acute and chronic discrimination. Soc Sci Med 199:167\u2013180. https:\/\/doi.org\/10.1016\/j.socscimed.2017.04.051","journal-title":"Soc Sci Med"},{"key":"972_CR7","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1038\/nri1106","volume":"3","author":"M Colonna","year":"2003","unstructured":"Colonna M (2003) TREMs in the immune system and beyond. Nat Rev Immunol 3:445\u2013453. https:\/\/doi.org\/10.1038\/nri1106","journal-title":"Nat Rev Immunol"},{"key":"972_CR8","doi-asserted-by":"publisher","DOI":"10.1042\/BSR20210940","author":"AH de Nooijer","year":"2021","unstructured":"de Nooijer AH, Grondman I, Lambden S et al (2021) Increased sTREM-1 plasma concentrations are associated with poor clinical outcomes in patients with COVID-19. Biosci Rep. https:\/\/doi.org\/10.1042\/BSR20210940","journal-title":"Biosci Rep"},{"key":"972_CR9","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1080\/1040841X.2020.1751060","volume":"46","author":"A de Oliveira Matos","year":"2020","unstructured":"de Oliveira Matos A, dos Santos Dantas PH, Figueira Marques Silva-Sales M, Sales-Campos H (2020) The role of the triggering receptor expressed on myeloid cells-1 (TREM-1) in non-bacterial infections. Crit Rev Microb 46:237\u2013252. https:\/\/doi.org\/10.1080\/1040841X.2020.1751060","journal-title":"Crit Rev Microb"},{"key":"972_CR10","first-page":"722","volume":"20","author":"A de S\u00e1 Resende","year":"2021","unstructured":"de S\u00e1 Resende A, de Oliveira YLM, de Moura TR, Martins-Filho PR (2021) Potential role of triggering receptor expressed on myeloid cells-1 (Trem-1) in sars-cov-2 infection: first insights. EXCLI J 20:722\u2013723","journal-title":"EXCLI J"},{"key":"972_CR11","doi-asserted-by":"publisher","first-page":"1169","DOI":"10.1007\/s10753-016-0351-1","volume":"39","author":"Y Du","year":"2016","unstructured":"Du Y, Wu T, Zhou XJ et al (2016) Blockade of CD354 (TREM-1) ameliorates anti-GBM-induced nephritis. Inflammation 39:1169\u20131176. https:\/\/doi.org\/10.1007\/s10753-016-0351-1","journal-title":"Inflammation"},{"key":"972_CR12","doi-asserted-by":"publisher","first-page":"799","DOI":"10.1111\/jcpe.12925","volume":"45","author":"M Dubar","year":"2018","unstructured":"Dubar M, Carrasco K, Gibot S, Bisson C (2018) Effects of porphyromonas gingivalis LPS and LR12 peptide on TREM-1 expression by monocytes. J Clin Periodontol 45:799\u2013805. https:\/\/doi.org\/10.1111\/jcpe.12925","journal-title":"J Clin Periodontol"},{"key":"972_CR13","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1016\/j.autrev.2018.07.008","volume":"18","author":"S Gao","year":"2019","unstructured":"Gao S, Yi Y, Xia G et al (2019) The characteristics and pivotal roles of triggering receptor expressed on myeloid cells-1 in autoimmune diseases. Autoimmun Rev 18:25\u201335. https:\/\/doi.org\/10.1016\/j.autrev.2018.07.008","journal-title":"Autoimmun Rev"},{"key":"972_CR14","doi-asserted-by":"publisher","first-page":"485","DOI":"10.1186\/cc3732","volume":"9","author":"S Gibot","year":"2005","unstructured":"Gibot S (2005) Clinical review: role of triggering receptor expressed on myeloid cells-1 during sepsis. Crit Care 9:485\u2013489. https:\/\/doi.org\/10.1186\/cc3732","journal-title":"Crit Care"},{"key":"972_CR15","doi-asserted-by":"publisher","first-page":"817","DOI":"10.1016\/S0161-5890(02)00004-4","volume":"38","author":"MC Gingras","year":"2002","unstructured":"Gingras MC, Lapillonne H, Margolin JF (2002) TREM-1, MDL-1, and DAP12 expression is associated with a mature stage of myeloid development. Mol Immunol 38:817\u2013824. https:\/\/doi.org\/10.1016\/S0161-5890(02)00004-4","journal-title":"Mol Immunol"},{"key":"972_CR16","doi-asserted-by":"publisher","first-page":"4065","DOI":"10.4049\/jimmunol.179.6.4065","volume":"179","author":"V G\u00f3mez-Pi\u00f1a","year":"2007","unstructured":"G\u00f3mez-Pi\u00f1a V, Soares-Schanoski A, Rodr\u00edguez-Rojas A et al (2007) Metalloproteinases shed TREM-1 ectodomain from lipopolysaccharide-stimulated human monocytes. J Immunol 179:4065\u20134073. https:\/\/doi.org\/10.4049\/jimmunol.179.6.4065","journal-title":"J Immunol"},{"key":"972_CR17","doi-asserted-by":"publisher","first-page":"1539","DOI":"10.1002\/sim.1186","volume":"21","author":"JPT Higgins","year":"2002","unstructured":"Higgins JPT, Thompson SG (2002) Quantifying heterogeneity in a meta-analysis. Stat Med 21:1539\u20131558. https:\/\/doi.org\/10.1002\/sim.1186","journal-title":"Stat Med"},{"key":"972_CR18","unstructured":"Hodgens A, Gupta V (2022) Severe acute respiratory syndrome. http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/32644403. Accessed 20 Dec 2021"},{"key":"972_CR19","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1186\/1471-2288-5-13","volume":"5","author":"SP Hozo","year":"2005","unstructured":"Hozo SP, Djulbegovic B, Hozo I (2005) Estimating the mean and variance from the median, range, and the size of a sample. BMC Med Res Methodol 5:13. https:\/\/doi.org\/10.1186\/1471-2288-5-13","journal-title":"BMC Med Res Methodol"},{"key":"972_CR20","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1007\/s00005-017-0499-x","volume":"66","author":"M Jedynak","year":"2018","unstructured":"Jedynak M, Siemiatkowski A, Mroczko B et al (2018) Soluble TREM-1 serum level can early predict mortality of patients with sepsis, severe sepsis and septic shock. Arch Immunol Ther Exp (warsz) 66:299\u2013306. https:\/\/doi.org\/10.1007\/s00005-017-0499-x","journal-title":"Arch Immunol Ther Exp (warsz)"},{"key":"972_CR21","doi-asserted-by":"publisher","first-page":"587","DOI":"10.1007\/s00134-008-1333-z","volume":"35","author":"J Jiyong","year":"2009","unstructured":"Jiyong J, Tiancha H, Wei C, Huahao S (2009) Diagnostic value of the soluble triggering receptor expressed on myeloid cells-1 in bacterial infection: a meta-analysis. Intensive Care Med 35:587\u2013595. https:\/\/doi.org\/10.1007\/s00134-008-1333-z","journal-title":"Intensive Care Med"},{"key":"972_CR22","doi-asserted-by":"publisher","DOI":"10.1111\/ijcp.14697","author":"F Kerget","year":"2021","unstructured":"Kerget F, Kerget B, \u0130ba Y\u0131lmaz S, K\u0131z\u0131ltun\u00e7 A (2021) Evaluation of the relationship between TREM-1\/TREM-2 ratio and clinical course in COVID-19 pneumonia. Int J Clin Pract. https:\/\/doi.org\/10.1111\/ijcp.14697","journal-title":"Int J Clin Pract"},{"key":"972_CR23","doi-asserted-by":"publisher","DOI":"10.1111\/sji.12989","author":"X Luo","year":"2021","unstructured":"Luo X, Zhu Y, Mao J, Du R (2021) T cell immunobiology and cytokine storm of COVID-19. Scand J Immunol. https:\/\/doi.org\/10.1111\/sji.12989","journal-title":"Scand J Immunol"},{"key":"972_CR24","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1016\/j.ejim.2020.04.043","volume":"76","author":"PR Martins-Filho","year":"2020","unstructured":"Martins-Filho PR, Tavares CSS, Santos VS (2020) Factors associated with mortality in patients with COVID-19. a quantitative evidence synthesis of clinical and laboratory data. Eur J Intern Med 76:97\u201399. https:\/\/doi.org\/10.1016\/j.ejim.2020.04.043","journal-title":"Eur J Intern Med"},{"key":"972_CR25","doi-asserted-by":"publisher","first-page":"336","DOI":"10.1016\/j.ijsu.2010.02.007","volume":"8","author":"D Moher","year":"2010","unstructured":"Moher D, Liberati A, Tetzlaff J, Altman DG (2010) Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. Int J Surg 8:336\u2013341. https:\/\/doi.org\/10.1016\/j.ijsu.2010.02.007","journal-title":"Int J Surg"},{"key":"972_CR26","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1159\/000328413","volume":"83","author":"G Rohde","year":"2012","unstructured":"Rohde G, Radsak MP, Borg I et al (2012) Levels of soluble triggering receptor expressed on myeloid cells 1 in infectious exacerbations of chronic obstructive pulmonary disease. Respiration 83:133\u2013139. https:\/\/doi.org\/10.1159\/000328413","journal-title":"Respiration"},{"key":"972_CR27","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1186\/s13643-015-0004-8","volume":"4","author":"M Simmonds","year":"2015","unstructured":"Simmonds M (2015) Quantifying the risk of error when interpreting funnel plots. Syst Rev 4:24. https:\/\/doi.org\/10.1186\/s13643-015-0004-8","journal-title":"Syst Rev"},{"key":"972_CR28","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2015-010314","volume":"6","author":"L Su","year":"2016","unstructured":"Su L, Liu D, Chai W et al (2016) Role of sTREM-1 in predicting mortality of infection: a systematic review and meta-analysis. BMJ Open 6:e010314. https:\/\/doi.org\/10.1136\/bmjopen-2015-010314","journal-title":"BMJ Open"},{"key":"972_CR29","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1016\/j.pharmthera.2017.02.043","volume":"177","author":"A Tammaro","year":"2017","unstructured":"Tammaro A, Derive M, Gibot S et al (2017) TREM-1 and its potential ligands in non-infectious diseases: from biology to clinical perspectives. Pharm Ther 177:81\u201395. https:\/\/doi.org\/10.1016\/j.pharmthera.2017.02.043","journal-title":"Pharm Ther"},{"key":"972_CR30","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.570993","author":"L Tang","year":"2020","unstructured":"Tang L, Yin Z, Hu Y, Mei H (2020) Controlling cytokine storm is vital in COVID-19. Front Immunol. https:\/\/doi.org\/10.3389\/fimmu.2020.570993","journal-title":"Front Immunol"},{"key":"972_CR31","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1016\/j.jaci.2020.10.001","volume":"147","author":"M Van Singer","year":"2021","unstructured":"Van Singer M, Brahier T, Ngai M et al (2021) COVID-19 risk stratification algorithms based on sTREM-1 and IL-6 in emergency department. J Allergy Clin Immunol 147:99-106.e4. https:\/\/doi.org\/10.1016\/j.jaci.2020.10.001","journal-title":"J Allergy Clin Immunol"},{"key":"972_CR32","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1186\/1471-2288-14-135","volume":"14","author":"X Wan","year":"2014","unstructured":"Wan X, Wang W, Liu J, Tong T (2014) Estimating the sample mean and standard deviation from the sample size, median, range and\/or interquartile range. BMC Med Res Methodol 14:135. https:\/\/doi.org\/10.1186\/1471-2288-14-135","journal-title":"BMC Med Res Methodol"},{"key":"972_CR33","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1186\/s12916-020-01627-5","volume":"18","author":"SW Wright","year":"2020","unstructured":"Wright SW, Lovelace-Macon L, Hantrakun V et al (2020) sTREM-1 predicts mortality in hospitalized patients with infection in a tropical, middle-income country. BMC Med 18:159. https:\/\/doi.org\/10.1186\/s12916-020-01627-5","journal-title":"BMC Med"},{"key":"972_CR34","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1038\/s41392-020-00243-2","volume":"5","author":"L Yang","year":"2020","unstructured":"Yang L, Liu S, Liu J et al (2020) COVID-19: immunopathogenesis and Immunotherapeutics. Signal Transduct Target Ther 5:128. https:\/\/doi.org\/10.1038\/s41392-020-00243-2","journal-title":"Signal Transduct Target Ther"},{"key":"972_CR35","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmpb.2021.105996","volume":"202","author":"\u015e Ya\u015far","year":"2021","unstructured":"Ya\u015far \u015e, \u00c7olak C, Yolo\u011flu S (2021) Artificial intelligence-based prediction of Covid-19 severity on the results of protein profiling. Comput Methods Progr Biomed 202:105996. https:\/\/doi.org\/10.1016\/j.cmpb.2021.105996","journal-title":"Comput Methods Progr Biomed"},{"key":"972_CR36","doi-asserted-by":"publisher","first-page":"501","DOI":"10.1111\/resp.12270","volume":"19","author":"W Ye","year":"2014","unstructured":"Ye W, Hu Y, Zhang R, Ying K (2014) Diagnostic value of the soluble triggering receptor expressed on myeloid cells-1 in lower respiratory tract infections: a meta-analysis. Respirology 19:501\u2013507. https:\/\/doi.org\/10.1111\/resp.12270","journal-title":"Respirology"},{"key":"972_CR37","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1009804","volume":"17","author":"J Youngs","year":"2021","unstructured":"Youngs J, Provine NM, Lim N et al (2021) Identification of immune correlates of fatal outcomes in critically ill COVID-19 patients. Plos Pathog 17:e1009804. https:\/\/doi.org\/10.1371\/journal.ppat.1009804","journal-title":"Plos Pathog"},{"key":"972_CR38","doi-asserted-by":"publisher","first-page":"L426","DOI":"10.1152\/ajplung.00195.2015","volume":"310","author":"Z Yuan","year":"2016","unstructured":"Yuan Z, Syed M, Panchal D et al (2016) TREM-1-accentuated lung injury via miR-155 is inhibited by LP17 nanomedicine. Am J Physiol Cell Mol Physiol 310:L426\u2013L438. https:\/\/doi.org\/10.1152\/ajplung.00195.2015","journal-title":"Am J Physiol Cell Mol Physiol"},{"key":"972_CR39","doi-asserted-by":"publisher","first-page":"599","DOI":"10.7499\/j.issn.1008-8830.2016.07.006","volume":"18","author":"MF Zhong","year":"2016","unstructured":"Zhong MF, Zhao JM (2016) Diagnostic values of plasma CD64 and sTREM-1 for pediatric pneumonia. Zhongguo Dang Dai Er Ke Za Zhi 18:599\u2013602. https:\/\/doi.org\/10.7499\/j.issn.1008-8830.2016.07.006","journal-title":"Zhongguo Dang Dai Er Ke Za Zhi"}],"container-title":["Inflammopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10787-022-00972-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10787-022-00972-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10787-022-00972-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,26]],"date-time":"2022-05-26T11:26:28Z","timestamp":1653564388000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10787-022-00972-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3,28]]},"references-count":39,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2022,6]]}},"alternative-id":["972"],"URL":"https:\/\/doi.org\/10.1007\/s10787-022-00972-6","relation":{},"ISSN":["0925-4692","1568-5608"],"issn-type":[{"value":"0925-4692","type":"print"},{"value":"1568-5608","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,3,28]]},"assertion":[{"value":"13 February 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 March 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 March 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that there is no competing interest. All authors have approved the manuscript for submission.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}]}}