{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T13:56:27Z","timestamp":1787320587183,"version":"build-2736575974"},"reference-count":91,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Inflammopharmacol"],"published-print":{"date-parts":[[2022,6]]},"DOI":"10.1007\/s10787-022-00974-4","type":"journal-article","created":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T16:48:09Z","timestamp":1648831689000},"page":"737-748","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["Elucidating the role of hypoxia-inducible factor in rheumatoid arthritis"],"prefix":"10.1007","volume":"30","author":[{"given":"Essa M.","family":"Sabi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anuja","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziyad M.","family":"Althafar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0993-7708","authenticated-orcid":false,"given":"Tapan","family":"Behl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aayush","family":"Sehgal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sukhbir","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neelam","family":"Sharma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saurabh","family":"Bhatia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed","family":"Al-Harrasi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hosam M.","family":"Alqahtani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simona","family":"Bungau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,4,1]]},"reference":[{"key":"974_CR1","first-page":"20","volume":"64","author":"AM Abeles","year":"2006","unstructured":"Abeles AM, Pillinger MH (2006) The role of the synovial fibroblast in rheumatoid arthritis: cartilage destruction and the regulation of matrix metalloproteinases. Bull NYU Hosp Jt Dis 64:20\u201324","journal-title":"Bull NYU Hosp Jt Dis"},{"key":"974_CR2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2020.102645,52,(102645)","author":"A Achek","year":"2020","unstructured":"Achek A, Kwon H-K, Patra MC, Shah M, Hong R, Lee WH, Baek W-Y, Choi YS, Kim G-Y, Pham TLH, Suh C-H, Kim W, Hahm D-H, Choi S (2020) A peptide derived from the core \u03b2-sheet region of TIRAP decoys TLR4 and reduces inflammatory and autoimmune symptoms in murine models. EBioMedicine. https:\/\/doi.org\/10.1016\/j.ebiom.2020.102645,52,(102645)","journal-title":"EBioMedicine"},{"key":"974_CR3","doi-asserted-by":"publisher","first-page":"834","DOI":"10.1093\/rheumatology\/ken086","volume":"47","author":"JK Ahn","year":"2008","unstructured":"Ahn JK, Koh EM, Cha HS, Lee YS, Kim J, Bae EK et al (2008) Role of hypoxia-inducible factor-1alpha in hypoxia-induced expressions of IL-8, MMP-1 and MMP-3 in rheumatoid fibroblast-like synoviocytes. Rheumatology (oxford) 47:834\u2013839. https:\/\/doi.org\/10.1093\/rheumatology\/ken086","journal-title":"Rheumatology (oxford)"},{"key":"974_CR4","doi-asserted-by":"publisher","first-page":"R64","DOI":"10.1186\/ar2689","volume":"11","author":"MA Akhavani","year":"2009","unstructured":"Akhavani MA, Madden L, Buysschaert I, Sivakumar B, Kang N, Paleolog EM (2009) Hypoxia upregulates angiogenesis and synovial cell migration in rheumatoid arthritis. Arthritis Res Ther 11:R64. https:\/\/doi.org\/10.1186\/ar2689","journal-title":"Arthritis Res Ther"},{"issue":"3","key":"974_CR5","doi-asserted-by":"publisher","first-page":"336","DOI":"10.1124\/jpet.117.242503.PMID28928122","volume":"363","author":"JL Ariazi","year":"2017","unstructured":"Ariazi JL, Duffy KJ, Adams DF, Fitch DM, Luo L, Pappalardi M et al (2017) Discovery and preclinical characterization of GSK1278863 (Daprodustat), a small molecule hypoxia inducible factor-prolyl hydroxylase inhibitor for anemia. J Pharmacol Exp Ther 363(3):336\u2013347. https:\/\/doi.org\/10.1124\/jpet.117.242503.PMID28928122","journal-title":"J Pharmacol Exp Ther"},{"key":"974_CR6","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1111\/1756-185X.12280","volume":"17","author":"G Azizi","year":"2014","unstructured":"Azizi G, Boghozian R, Mirshafiey A (2014) The potential role of angiogenic factors in rheumatoid arthritis. Int J Rheum Dis 17:369\u2013383. https:\/\/doi.org\/10.1111\/1756-185X.12280","journal-title":"Int J Rheum Dis"},{"key":"974_CR7","doi-asserted-by":"publisher","first-page":"5549","DOI":"10.1074\/jbc.M113.500405","volume":"289","author":"J Bagnall","year":"2014","unstructured":"Bagnall J, Leedale J, Taylor SE, Spiller DG, White MR, Sharkey KJ, Bearon RN, See V (2014) Tight control of hypoxia-inducible factor-alpha transient dynamics is essential for cell survival in hypoxia. J Biol Chem 289:5549\u20135564","journal-title":"J Biol Chem"},{"key":"974_CR8","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1517\/13543776.2016.1146252","volume":"26","author":"HS Ban","year":"2016","unstructured":"Ban HS, Uto Y, Won M, Nakamura H (2016) Hypoxia-inducible factor (HIF) inhibitors: a patent survey (2011\u20132015). Expert Opin Ther Pat 26:309\u2013322. https:\/\/doi.org\/10.1517\/13543776.2016.1146252","journal-title":"Expert Opin Ther Pat"},{"key":"974_CR9","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1007\/s00109-011-0805-8","volume":"90","author":"CD Befani","year":"2012","unstructured":"Befani CD, Vlachostergios PJ, Hatzidaki E, Patrikidou A, Bonanou S, Simos G (2012) Bortezomib represses HIF-1\u03b1 protein expression and nuclear accumulation by inhibiting both PI3K\/Akt\/TOR and MAPK pathways in prostate cancer cells. J Mol Med 90:45\u201354","journal-title":"J Mol Med"},{"key":"974_CR10","doi-asserted-by":"publisher","first-page":"784","DOI":"10.1161\/01.RES.0000015588.70132.DC","volume":"90","author":"Y Ben-Yosef","year":"2002","unstructured":"Ben-Yosef Y, Lahat N, Shapiro S, Bitterman H, Miller A (2002) Regulation of endothelial matrix metalloproteinase-2 by hypoxia\/reoxygenation. Circ Res 90:784\u2013791. https:\/\/doi.org\/10.1161\/01.RES.0000015588.70132.DC","journal-title":"Circ Res"},{"key":"974_CR11","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2015-208476","author":"M Biniecka","year":"2016","unstructured":"Biniecka M, Canavan M, McGarry T, Gao W, McCormick J, Cregan S et al (2016) Dysregulated bioenergetics: a key regulator of joint inflammation. Ann Rheum Dis. https:\/\/doi.org\/10.1136\/annrheumdis-2015-208476","journal-title":"Ann Rheum Dis"},{"key":"974_CR12","doi-asserted-by":"publisher","first-page":"1833","DOI":"10.1002\/art.23516","volume":"58","author":"MC Bosco","year":"2008","unstructured":"Bosco MC, Delfino S, Ferlito F, Battaglia F, Puppo M, Gregorio A et al (2008) Hypoxic synovial environment and expression of macrophage inflammatory protein 3gamma\/CCL20 in juvenile idiopathic arthritis. Arthritis Rheum 58:1833\u20131838. https:\/\/doi.org\/10.1002\/art.23516","journal-title":"Arthritis Rheum"},{"key":"974_CR13","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1016\/j.cellimm.2005.04.018","volume":"233","author":"F Brentano","year":"2005","unstructured":"Brentano F, Kyburz D, Schorr O, Gay R, Gay S (2005) The role of Toll-like receptor signalling in the pathogenesis of arthritis. Cell Immunol 233:90\u201396. https:\/\/doi.org\/10.1016\/j.cellimm.2005.04.018","journal-title":"Cell Immunol"},{"key":"974_CR14","first-page":"945","volume":"27","author":"E Brouwer","year":"2009","unstructured":"Brouwer E, Gouw AS, Posthumus MD, van Leeuwen MA, Boerboom AL, Bijzet J et al (2009) Hypoxia inducible factor-1-alpha (HIF-1alpha) is related to both angiogenesis and inflammation in rheumatoid arthritis. Clin Exp Rheumatol 27:945\u2013951","journal-title":"Clin Exp Rheumatol"},{"key":"974_CR15","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1006\/excr.2001.5243","volume":"267","author":"MT Canning","year":"2001","unstructured":"Canning MT, Postovit LM, Clarke SH, Graham CH (2001) Oxygen-mediated regulation of gelatinase and tissue inhibitor of metalloproteinases-1 expression by invasive cells. Exp Cell Res 267:88\u201394. https:\/\/doi.org\/10.1006\/excr.2001.5243","journal-title":"Exp Cell Res"},{"key":"974_CR16","first-page":"593","volume":"21","author":"HS Cha","year":"2003","unstructured":"Cha HS, Ahn KS, Jeon CH, Kim J, Song YW, Koh EM (2003) Influence of hypoxia on the expression of matrix metalloproteinase-1, -3 and tissue inhibitor of metalloproteinase-1 in rheumatoid synovial fibroblasts. Clin Exp Rheumatol 21:593\u2013598","journal-title":"Clin Exp Rheumatol"},{"key":"974_CR17","doi-asserted-by":"publisher","first-page":"33714","DOI":"10.1074\/jbc.M704041200","volume":"282","author":"M Charbonneau","year":"2007","unstructured":"Charbonneau M, Harper K, Grondin F, Pelmus M, McDonald PP, Dubois CM (2007) Hypoxia-inducible factor mediates hypoxic and tumor necrosis factor alpha-induced increases in tumor necrosis factor-alpha converting enzyme\/ADAM17 expression by synovial cells. J Biol Chem 282:33714\u201333724. https:\/\/doi.org\/10.1074\/jbc.M704041200","journal-title":"J Biol Chem"},{"key":"974_CR18","doi-asserted-by":"publisher","first-page":"991","DOI":"10.2147\/IJN.S101872","volume":"11","author":"Z Chen","year":"2016","unstructured":"Chen Z, Zhang T, Wu B, Zhang X (2016) Insights into the therapeutic potential of hypoxia-inducible factor-1alpha small interfering RNA in malignant melanoma delivered via folate-decorated cationic liposomes. Int J Nanomed 11:991\u20131002. https:\/\/doi.org\/10.2147\/IJN.S101872","journal-title":"Int J Nanomed"},{"issue":"6204","key":"974_CR20","doi-asserted-by":"publisher","first-page":"1250684","DOI":"10.1126\/science.1250684","volume":"345","author":"SC Cheng","year":"2014","unstructured":"Cheng SC, Quintin J, Cramer RA et al (2014) mTOR-and HIF-1\u03b1\u2013mediated aerobic glycolysis as metabolic basis for trained immunity. Science 345(6204):1250684","journal-title":"Science"},{"key":"974_CR99","doi-asserted-by":"publisher","DOI":"10.1016\/j.abb.2020.108297","author":"Z Chi","year":"2020","unstructured":"Chi Z, Jun C, Weiwei W, Yuan D, Ping Z, Wei J, Chao W, Fei H (2020) Activation of GPR43 suppresses TNF-\u03b1-induced inflammatory response in human fibroblast like synoviocytes. Arch Biochem Biophys. https:\/\/doi.org\/10.1016\/j.abb.2020.108297","journal-title":"Arch Biochem Biophys"},{"key":"974_CR21","doi-asserted-by":"publisher","first-page":"645","DOI":"10.1016\/S0092-8674(03)00154-5","volume":"112","author":"T Cramer","year":"2003","unstructured":"Cramer T, Yamanishi Y, Clausen BE, F\u00f6rster I, Pawlinski R, Mackman N et al (2003) HIF-1\u03b1 is essential for myeloid cell-mediated inflammation. Cell 112:645\u2013657. https:\/\/doi.org\/10.1016\/S0092-8674(03)00154-5","journal-title":"Cell"},{"key":"974_CR22","doi-asserted-by":"publisher","first-page":"4853","DOI":"10.4049\/jimmunol.171.9.4853","volume":"171","author":"M De Bandt","year":"2003","unstructured":"De Bandt M, Ben Mahdi MH, Ollivier V, Grossin M, Dupuis M, Gaudry M et al (2003) Blockade of vascular endothelial growth factor receptor I (VEGF-RI), but not VEGF-RII, suppresses joint destruction in the K\/BxN model of rheumatoid arthritis. J Immunol 171:4853\u20134859. https:\/\/doi.org\/10.4049\/jimmunol.171.9.4853","journal-title":"J Immunol"},{"key":"974_CR23","doi-asserted-by":"publisher","first-page":"2926","DOI":"10.1002\/art.24844","volume":"60","author":"MJ del Rey","year":"2009","unstructured":"del Rey MJ, Izquierdo E, Caja S, Usategui A, Santiago B, Galindo M et al (2009) Human inflammatory synovial fibroblasts induce enhanced myeloid cell recruitment and angiogenesis through a hypoxia-inducible transcription factor 1alpha\/vascular endothelial growth factor-mediated pathway in immunodeficient mice. Arthritis Rheum 60:2926\u20132934. https:\/\/doi.org\/10.1002\/art.24844","journal-title":"Arthritis Rheum"},{"issue":"3","key":"974_CR24","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1111\/febs.13578","volume":"283","author":"L D'Ignazio","year":"2016","unstructured":"D\u2019Ignazio L, Bandarra D, Rocha S (2016) NF-\u03baB and HIF crosstalk in immune responses. Febs J 283(3):413\u2013424","journal-title":"Febs J"},{"key":"974_CR25","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1002\/art.11425","volume":"50","author":"JH Distler","year":"2004","unstructured":"Distler JH, Wenger RH, Gassmann M, Kurowska M, Hirth A, Gay S et al (2004) Physiologic responses to hypoxia and implications for hypoxia-inducible factors in the pathogenesis of rheumatoid arthritis. Arthritis Rheum 50:10\u201323. https:\/\/doi.org\/10.1002\/art.11425","journal-title":"Arthritis Rheum"},{"key":"974_CR26","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1007\/s10456-015-9477-2","volume":"18","author":"HA Elshabrawy","year":"2015","unstructured":"Elshabrawy HA, Chen Z, Volin MV, Ravella S, Virupannavar S, Shahrara S (2015) The pathogenic role of angiogenesis in rheumatoid arthritis. Angiogenesis 18:433\u2013448. https:\/\/doi.org\/10.1007\/s10456-015-9477-2","journal-title":"Angiogenesis"},{"key":"974_CR27","doi-asserted-by":"publisher","first-page":"656","DOI":"10.1056\/NEJMra0910283","volume":"364","author":"HK Eltzschig","year":"2011","unstructured":"Eltzschig HK, Carmeliet P (2011) Hypoxia and inflammation. N Engl J Med 364:656\u2013665. https:\/\/doi.org\/10.1056\/NEJMra0910283","journal-title":"N Engl J Med"},{"key":"974_CR28","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/","volume":"2014","author":"L Fan","year":"2014","unstructured":"Fan L, Li J, Yu Z, Dang X, Wang K (2014) The hypoxia-inducible factor pathway, prolyl hydroxylase domain protein inhibitors, and their roles in bone repair and regeneration. Biomed Res Int 2014:239356. https:\/\/doi.org\/10.1155\/2014\/","journal-title":"Biomed Res Int"},{"issue":"11","key":"974_CR29","doi-asserted-by":"publisher","first-page":"838","DOI":"10.1371\/journal.pone.0111838","volume":"9","author":"I Flamme","year":"2014","unstructured":"Flamme I, Oehme F, Ellinghaus P, Jeske M, Keldenich J, Thuss U (2014) Mimicking hypoxia to treat anemia: HIF-stabilizer BAY 85\u20133934 (Molidustat) stimulates erythropoietin production without hypertensive effects. PLoS ONE 9(11):838. https:\/\/doi.org\/10.1371\/journal.pone.0111838 (PMC\u00a04230943. PMID\u00a025392999)","journal-title":"PLoS ONE"},{"key":"974_CR30","doi-asserted-by":"publisher","first-page":"971","DOI":"10.1136\/ard.2004.031641","volume":"64","author":"T Gaber","year":"2005","unstructured":"Gaber T, Dziurla R, Tripmacher R, Burmester GR, Buttgereit F (2005) Hypoxia inducible factor (HIF) in rheumatology: low O2! See what HIF can do! Ann Rheum Dis 64:971\u2013980. https:\/\/doi.org\/10.1136\/ard.2004.031641","journal-title":"Ann Rheum Dis"},{"key":"974_CR31","doi-asserted-by":"publisher","first-page":"2104","DOI":"10.1002\/art.34397","volume":"64","author":"W Gao","year":"2012","unstructured":"Gao W, Sweeney C, Connolly M, Kennedy A, Ng CT, McCormick J et al (2012) Notch-1 mediates hypoxia-induced angiogenesis in rheumatoid arthritis. Arthritis Rheum 64:2104\u20132113. https:\/\/doi.org\/10.1002\/art.34397","journal-title":"Arthritis Rheum"},{"key":"974_CR32","doi-asserted-by":"publisher","first-page":"R193","DOI":"10.1186\/ar756","volume":"5","author":"A Giatromanolaki","year":"2003","unstructured":"Giatromanolaki A, Sivridis E, Maltezos E, Athanassou N, Papazoglou D, Gatter KC et al (2003) Upregulated hypoxia inducible factor-1\u03b1 and -2\u03b1 pathway in rheumatoid arthritis and osteoarthritis. Arthritis Res Ther 5:R193\u2013R201. https:\/\/doi.org\/10.1186\/ar756","journal-title":"Arthritis Res Ther"},{"key":"974_CR33","doi-asserted-by":"publisher","first-page":"563","DOI":"10.1007\/s00424-007-0310-7","volume":"455","author":"JS Gibson","year":"2008","unstructured":"Gibson JS, Milner PI, White R, Fairfax TP, Wilkins RJ (2008) Oxygen and reactive oxygen species in articular cartilage: modulators of ionic homeostasis. Pflug Arch 455:563\u2013573. https:\/\/doi.org\/10.1007\/s00424-007-0310-7","journal-title":"Pflug Arch"},{"key":"974_CR34","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1093\/rheumatology\/ker257","volume":"51","author":"FG Goh","year":"2012","unstructured":"Goh FG, Midwood KS (2012) Intrinsic danger: activation of Toll-like receptors in rheumatoid arthritis. Rheumatology (oxford) 51:7\u201323. https:\/\/doi.org\/10.1093\/rheumatology\/ker257","journal-title":"Rheumatology (oxford)"},{"issue":"Suppl. 2","key":"974_CR35","doi-asserted-by":"publisher","first-page":"ii11","DOI":"10.1093\/rheumatology\/keg327","volume":"42","author":"SR Goldring","year":"2003","unstructured":"Goldring SR (2003) Pathogenesis of bone and cartilage destruction in rheumatoid arthritis. Rheumatology 42(Suppl. 2):ii11\u2013ii16. https:\/\/doi.org\/10.1093\/rheumatology\/keg327","journal-title":"Rheumatology"},{"key":"974_CR36","doi-asserted-by":"publisher","first-page":"2448","DOI":"10.1038\/emboj.2012.125","volume":"31","author":"SN Greer","year":"2012","unstructured":"Greer SN, Metcalf JL, Wang Y, Ohh M (2012) The updated biology of hypoxia-inducible factor. EMBO J 31:2448\u20132460. https:\/\/doi.org\/10.1038\/emboj.2012.125","journal-title":"EMBO J"},{"key":"974_CR37","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1136\/annrheumdis-2014-eular","volume":"73","author":"W Hardy","year":"2014","unstructured":"Hardy W, Wright F, Hawtree S, Fearon U, Veale D, Perretti M et al (2014) Hypoxia-inducible factor 2a regulates macrophage function in rheumatoid arthritis. Ann Rheum Dis 73:174. https:\/\/doi.org\/10.1136\/annrheumdis-2014-eular","journal-title":"Ann Rheum Dis"},{"key":"974_CR39","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-030-12734-3_8","volume-title":"Hypoxia and cancer metastasis. Advances in experimental medicine and biology","author":"S Hatfield","year":"2019","unstructured":"Hatfield S, Veszeleiova K, Steingold J, Sethuraman J, Sitkovsky M (2019) Mechanistic justifications of systemic therapeutic oxygenation of tumors to weaken the hypoxia inducible factor 1\u03b1-mediated immunosuppression. In: Gilkes D (ed) Hypoxia and cancer metastasis. Advances in experimental medicine and biology, vol 1136. Springer, Cham. https:\/\/doi.org\/10.1007\/978-3-030-12734-3_8"},{"key":"974_CR40","doi-asserted-by":"publisher","first-page":"3885","DOI":"10.1007\/s00018-011-0679-5","volume":"68","author":"M Heikkila","year":"2011","unstructured":"Heikkila M, Pasanen A, Kivirikko KI, Myllyharju J (2011) Roles of the human hypoxia-inducible factor (HIF)-3 alpha variants in the hypoxia response. Cell Mol Life Sci 68:3885\u20133901","journal-title":"Cell Mol Life Sci"},{"issue":"5","key":"974_CR41","doi-asserted-by":"publisher","first-page":"468","DOI":"10.3390\/biomedicines9050468","volume":"9","author":"K Hirota","year":"2021","unstructured":"Hirota K (2021) HIF-\u03b1 prolyl hydroxylase inhibitors and their implications for biomedicine: a comprehensive review. Biomedicines 9(5):468. https:\/\/doi.org\/10.3390\/biomedicines9050468 (PMC8146675. PMID33923349)","journal-title":"Biomedicines"},{"key":"974_CR42","doi-asserted-by":"publisher","first-page":"2587","DOI":"10.1002\/art.10520","volume":"46","author":"C Hitchon","year":"2002","unstructured":"Hitchon C, Wong K, Ma G, Reed J, Lyttle D, El-Gabalawy H (2002) Hypoxia-induced production of stromal cell-derived factor 1 (CXCL12) and vascular endothelial growth factor by synovial fibroblasts. Arthritis Rheum 46:2587\u20132597. https:\/\/doi.org\/10.1002\/art.10520","journal-title":"Arthritis Rheum"},{"key":"974_CR43","doi-asserted-by":"publisher","first-page":"464","DOI":"10.1126\/science.1059817","volume":"292","author":"M Ivan","year":"2001","unstructured":"Ivan M, Kondo K, Yang H, Kim W, Valiando J, Ohh M, Salic A, Asara JM, Lane WS, Kaelin WG Jr (2001) HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: Implications for O2 sensing. Science 292:464\u2013468","journal-title":"Science"},{"key":"974_CR44","doi-asserted-by":"publisher","first-page":"468","DOI":"10.1126\/science.1059796","volume":"292","author":"P Jaakkola","year":"2001","unstructured":"Jaakkola P, Mole DR, Tian YM, Wilson MI, Gielbert J, Gaskell SJ, von Kriegsheim A, Hebestreit HF, Mukherji M, Schofield CJ et al (2001) Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation. Science 292:468\u2013472","journal-title":"Science"},{"issue":"5","key":"974_CR97","doi-asserted-by":"publisher","first-page":"3406","DOI":"10.1002\/jcp.30125","volume":"236","author":"X Jiaming","year":"2020","unstructured":"Jiaming X, Suarez JS, Minaai M, Shuangjing L, Gaudino G, Pass HI, Carbone M, Yang H (2020) HMGB1 as a therapeutic target in disease. J Cell Physiol 236(5):3406\u20133419. https:\/\/doi.org\/10.1002\/jcp.30125","journal-title":"J Cell Physiol"},{"key":"974_CR45","doi-asserted-by":"publisher","first-page":"2854","DOI":"10.1002\/art.22853","volume":"56","author":"W Kammouni","year":"2007","unstructured":"Kammouni W, Wong K, Ma G, Firestein GS, Gibson SB, ElGabalawy HS (2007) Regulation of apoptosis in fibroblast-like synoviocytes by the hypoxia-induced Bcl-2 family member Bcl-2\/adenovirus E1B 19-kd protein-interacting protein 3. Arthritis Rheum 56:2854\u20132863","journal-title":"Arthritis Rheum"},{"issue":"1","key":"974_CR46","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1007\/s40262-017-0551-3.PMC5766731.PMID28508936","volume":"57","author":"KA Kansagra","year":"2018","unstructured":"Kansagra KA, Parmar D, Jani RH, Srinivas NR, Lickliter J, Patel HV et al (2018) Phase I clinical study of ZYAN1, a novel prolyl-hydroxylase (PHD) inhibitor to evaluate the safety, tolerability, and pharmacokinetics following oral administration in healthy volunteers. Clin Pharmacokinet 57(1):87\u2013102. https:\/\/doi.org\/10.1007\/s40262-017-0551-3.PMC5766731.PMID28508936","journal-title":"Clin Pharmacokinet"},{"issue":"10","key":"974_CR47","doi-asserted-by":"publisher","first-page":"754","DOI":"10.1038\/ja.2016.20","volume":"69","author":"H Kobayashi","year":"2016","unstructured":"Kobayashi H, Ohyama T, Kitamura-Miyazaki M et al (2016) Studies on novel HIF activators, A-503451sII: biological activities of A-503451A. J Antibiot 69(10):754\u2013758","journal-title":"J Antibiot"},{"key":"974_CR48","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1158\/1535-7163.MCT-07-0463","volume":"7","author":"MY Koh","year":"2008","unstructured":"Koh MY, Spivak-Kroizman T, Venturini S, Welsh S, Williams RR, Kirkpatrick DL (2008) Molecular mechanisms for the activity of PX-478, an antitumor inhibitor of the hypoxia-inducible factor-1\u03b1. Mol Cancer Ther 7:90\u2013100","journal-title":"Mol Cancer Ther"},{"issue":"4","key":"974_CR49","doi-asserted-by":"publisher","first-page":"512","DOI":"10.1111\/imm.12380","volume":"143","author":"V Kumar","year":"2014","unstructured":"Kumar V, Gabrilovich DI (2014) Hypoxia-inducible factors in regulation of immune responses in tumour microenvironment. Immunology 143(4):512\u2013519","journal-title":"Immunology"},{"key":"974_CR50","doi-asserted-by":"publisher","first-page":"1466","DOI":"10.1101\/gad.991402","volume":"16","author":"D Lando","year":"2002","unstructured":"Lando D, Peet DJ, Gorman JJ, Whelan DA, Whitelaw ML, Bruick RK (2002) (2002) FIH-1 is an asparaginyl hydroxylase enzyme that regulates the transcriptional activity of hypoxia-inducible factor. Genes Dev 16:1466\u20131471","journal-title":"Genes Dev"},{"key":"974_CR51","doi-asserted-by":"publisher","first-page":"e118","DOI":"10.1016\/j.vph.2006.08.317","volume":"45","author":"H Larsen","year":"2006","unstructured":"Larsen H, Feldmann M, Paleolog EM (2006) (2006) Synovial fibroblasts are important mediators of synovial angiogenesis in the hypoxic rheumatoid joint. Vasc Pharmacol 45:e118","journal-title":"Vasc Pharmacol"},{"key":"974_CR52","doi-asserted-by":"publisher","first-page":"864","DOI":"10.1016\/j.molcel.2010.05.023","volume":"38","author":"JH Lim","year":"2010","unstructured":"Lim JH, Lee YM, Chun YS, Chen JJ, Kim JE, Park JW (2010) (2010) Sirtuin 1 modulates cellular responses to hypoxia by deacetylating hypoxia-inducible factor 1\u03b1. Mol Cell 38:864\u2013878","journal-title":"Mol Cell"},{"key":"974_CR53","doi-asserted-by":"publisher","first-page":"919","DOI":"10.4161\/cc.6.8.4133","volume":"6","author":"T Lofstedt","year":"2007","unstructured":"Lofstedt T, Fredlund E, Holmquist-Mengelbier L, Pietras A, Ovenberger M, Poellinger L, Pahlman S (2007) Hypoxia inducible factor-2alpha in cancer. Cell Cycle 6:919\u2013926","journal-title":"Cell Cycle"},{"key":"974_CR54","doi-asserted-by":"publisher","first-page":"2675","DOI":"10.1101\/gad.924501","volume":"15","author":"PC Mahon","year":"2001","unstructured":"Mahon PC, Hirota K, Semenza GL (2001) FIH-1: A novel protein that interacts with HIF-1alpha and VHL to mediate repression of HIF-1 transcriptional activity. Genes Dev 15:2675\u20132686","journal-title":"Genes Dev"},{"key":"974_CR55","doi-asserted-by":"publisher","first-page":"32405","DOI":"10.1074\/jbc.C200328200","volume":"277","author":"Y Makino","year":"2002","unstructured":"Makino Y, Kanopka A, Wilson WJ, Tanaka H, Poellinger L (2002) Inhibitory PAS domain protein (IPAS) is a hypoxia-inducible splicing variant of the hypoxia-inducible factor-3 alpha locus. J Biol Chem 277:32405\u201332408","journal-title":"J Biol Chem"},{"key":"974_CR56","doi-asserted-by":"publisher","first-page":"14073","DOI":"10.1074\/jbc.M700732200","volume":"282","author":"Y Makino","year":"2007","unstructured":"Makino Y, Uenishi R, Okamoto K, Isoe T, Hosono O, Tanaka H, Kanopka A, Poellinger L, Haneda M, Morimoto C (2007) Transcriptional up-regulation of inhibitory PAS domain protein gene expression by hypoxia-inducible factor 1 (HIF-1)\u2014a negative feedback regulatory circuit in HIF-1-mediated signaling in hypoxic cells. J Biol Chem 282:14073\u201314082","journal-title":"J Biol Chem"},{"key":"974_CR57","doi-asserted-by":"publisher","first-page":"5197","DOI":"10.1093\/emboj\/20.18.5197","volume":"20","author":"N Masson","year":"2001","unstructured":"Masson N, Willam C, Maxwell PH, Pugh CW, Ratcliffe PJ (2001) Independent function of two destruction domains in hypoxia-inducible factor-alpha chains activated by prolyl hydroxylation. EMBO J 20:5197\u20135206","journal-title":"EMBO J"},{"key":"974_CR58","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1038\/20459","volume":"399","author":"PH Maxwell","year":"1999","unstructured":"Maxwell PH, Wiesener MS, Chang GW, Clifford SC, Vaux EC, Cockman ME, Wykoff CC, Pugh CW, Maher ER, Ratcliffe PJ (1999) The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis. Nature 399:271\u2013275","journal-title":"Nature"},{"key":"974_CR59","doi-asserted-by":"publisher","first-page":"1396","DOI":"10.1096\/fj.05-3788com","volume":"19","author":"MA Maynard","year":"2005","unstructured":"Maynard MA, Evans AJ, Hosomi T, Hara S, Jewett MA, Ohh M (2005) Human HIF-3alpha4 is a dominant-negative regulator of HIF-1 and is down-regulated in renal cell carcinoma. FASEB J 19:1396\u20131406","journal-title":"FASEB J"},{"key":"974_CR60","doi-asserted-by":"publisher","first-page":"632","DOI":"10.1016\/j.trecan.2019.08.005","volume":"5","author":"D Mennerich","year":"2019","unstructured":"Mennerich D, Kubaichuk K, Kietzmann T (2019) DUBs, hypoxia, and cancer. Trends Cancer 5:632\u2013653","journal-title":"Trends Cancer"},{"key":"974_CR61","doi-asserted-by":"publisher","first-page":"2183","DOI":"10.1002\/hep.23597","volume":"51","author":"H Menrad","year":"2010","unstructured":"Menrad H, Werno C, Schmid T, Copanaki E, Deller T, Dehne N, Brune B (2010) Roles of hypoxia-inducible factor-1alpha (HIF-1alpha) versus HIF-2alpha in the survival of hepatocellular tumor spheroids. Hepatology 51:2183\u20132192","journal-title":"Hepatology"},{"key":"974_CR62","doi-asserted-by":"publisher","first-page":"355","DOI":"10.2174\/138945006776054979","volume":"7","author":"DG Nagle","year":"2006","unstructured":"Nagle DG, Zhou YD (2006) Natural product-based inhibitors of hypoxia-inducible factor-1 (HIF-1). Curr Drug Targets 7:355\u2013369","journal-title":"Curr Drug Targets"},{"key":"974_CR63","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1038\/35017054","volume":"2","author":"M Ohh","year":"2000","unstructured":"Ohh M, Park CW, Ivan M, Hoffman MA, Kim TY, Huang LE, Pavletich N, Chau V, Kaelin WG (2000) Ubiquitination of hypoxia-inducible factor requires direct binding to the beta-domain of the von Hippel-Lindau protein. Nat Cell Biol 2:423\u2013427","journal-title":"Nat Cell Biol"},{"issue":"1","key":"974_CR64","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1016\/j.cmet.2014.12.005","volume":"1","author":"EM Palsson-McDermott","year":"2015","unstructured":"Palsson-McDermott EM, Curtis AM, Goel G et al (2015) Pyruvate kinase M2 regulates Hif-1\u03b1 activity and IL-1\u03b2 induction and is a critical determinant of the warburg effect in LPS-activated macrophages. Cell Metab 1(1):65\u201380","journal-title":"Cell Metab"},{"key":"974_CR65","doi-asserted-by":"publisher","first-page":"604","DOI":"10.1038\/sj.onc.1209818","volume":"26","author":"S Paltoglou","year":"2007","unstructured":"Paltoglou S, Roberts BJ (2007) HIF-1alpha and EPAS ubiquitination mediated by the VHL tumour suppressor involves flexibility in the ubiquitination mechanism, similar to other RING E3 ligases. Oncogene 26:604\u2013609","journal-title":"Oncogene"},{"key":"974_CR66","doi-asserted-by":"publisher","first-page":"1189","DOI":"10.1016\/j.biocel.2010.04.008","volume":"42","author":"A Pasanen","year":"2010","unstructured":"Pasanen A, Heikkila M, Rautavuoma K, Hirsila M, Kivirikko KI, Myllyharju J (2010) Hypoxia-inducible factor (HIF)-3a is subject to extensive alternative splicing in human tissues and cancer cells and is regulated by HIF-1 but not HIF-2. Int J Biochem Cell Biol 42:1189\u20131200","journal-title":"Int J Biochem Cell Biol"},{"key":"974_CR67","doi-asserted-by":"publisher","first-page":"926","DOI":"10.1016\/j.tcb.2018.07.005","volume":"28","author":"D Ribet","year":"2018","unstructured":"Ribet D, Cossart P (2018) Ubiquitin, SUMO, and NEDD8: (2018) key targets of bacterial pathogens. Trends Cell Biol 28:926\u2013940","journal-title":"Trends Cell Biol"},{"issue":"7196","key":"974_CR68","doi-asserted-by":"publisher","first-page":"807","DOI":"10.1038\/nature06905","volume":"453","author":"J Rius","year":"2008","unstructured":"Rius J, Guma M, Schachtrup C et al (2008) (2008) NF-\u03baB links innate immunity to the hypoxic response through transcriptional regulation of HIF-1\u03b1. Nature 453(7196):807\u2013811","journal-title":"Nature"},{"issue":"8","key":"974_CR69","doi-asserted-by":"publisher","first-page":"901","DOI":"10.1080\/13543784.2016.1182981.PMID27122198.S2CID32493057","volume":"25","author":"H Schmid","year":"2016","unstructured":"Schmid H, Jelkmann W (2016) Investigational therapies for renal disease-induced anemia. Expert Opin Investig Drugs 25(8):901\u2013916. https:\/\/doi.org\/10.1080\/13543784.2016.1182981.PMID27122198.S2CID32493057","journal-title":"Expert Opin Investig Drugs"},{"key":"974_CR70","doi-asserted-by":"publisher","first-page":"53","DOI":"10.3389\/fonc.2016.00053","volume":"6","author":"AS Schober","year":"2016","unstructured":"Schober AS, Berra E (2016) DUBs, new members in the hypoxia signaling club. Front Oncol 6:53","journal-title":"Front Oncol"},{"key":"974_CR71","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1016\/j.yexcr.2017.03.041","volume":"356","author":"GL Semenza","year":"2017","unstructured":"Semenza GL (2017) A compendium of proteins that interact with HIF-1 alpha. Exp Cell Res 356:128\u2013135","journal-title":"Exp Cell Res"},{"issue":"1","key":"974_CR72","doi-asserted-by":"publisher","first-page":"e46401","DOI":"10.15252\/embr.201846401","volume":"20","author":"JA Smythies","year":"2019","unstructured":"Smythies JA, Sun M, Masson N, Salama R, Simpson PD, Murray E, Neumann V, Cockman ME, Choudhry H, Ratcliffe PJ, Mole DR (2019) Inherent DNA-binding specificities of the HIF-1\u03b1 and HIF-2\u03b1 transcription factors in chromatin. EMBO Rep 20(1):e46401. https:\/\/doi.org\/10.15252\/embr.201846401","journal-title":"EMBO Rep"},{"key":"974_CR73","first-page":"6130","volume":"63","author":"HM Sowter","year":"2003","unstructured":"Sowter HM, Raval RR, Moore JW, Ratcliffe PJ, Harris AL (2003) (2003) Predominant role of hypoxia-inducible transcription factor (Hif)- 1alpha versus Hif-2alpha in regulation of the transcriptional response to hypoxia. Cancer Res 63:6130\u20136134","journal-title":"Cancer Res"},{"key":"974_CR74","doi-asserted-by":"publisher","first-page":"23482","DOI":"10.1074\/jbc.M601719200","volume":"281","author":"DP Stiehl","year":"2006","unstructured":"Stiehl DP, Wirthner R, Koditz J, Spielmann P, Camenisch G, Wenger RH (2006) Increased prolyl 4-hydroxylase domain proteins compensate for decreased oxygen levels. Evidence for an autoregulatory oxygen-sensing system. J Biol Chem 281:23482\u201323491","journal-title":"J Biol Chem"},{"key":"974_CR75","doi-asserted-by":"publisher","first-page":"4298","DOI":"10.1093\/emboj\/19.16.4298","volume":"19","author":"K Tanimoto","year":"2000","unstructured":"Tanimoto K, Makino Y, Pereira T, Poellinger L (2000) Mechanism of regulation of the hypoxia-inducible factor-1 alpha by the von Hippel-Lindau tumor suppressor protein. EMBO J 19:4298\u20134309","journal-title":"EMBO J"},{"issue":"9","key":"974_CR76","doi-asserted-by":"publisher","first-page":"C580","DOI":"10.1152\/ajpcell.00204.2015","volume":"309","author":"JH Tao","year":"2015","unstructured":"Tao JH, Barbi J, Pan F (2015) Hypoxia-inducible factors in T lymphocyte differentiation and function. A review in the theme: cellular responses to hypoxia. Am J Physiol Cell Physiol 309(9):C580\u2013C589","journal-title":"Am J Physiol Cell Physiol"},{"issue":"9","key":"974_CR77","doi-asserted-by":"publisher","first-page":"160195","DOI":"10.1098\/rsob.160195","volume":"6","author":"SE Taylor","year":"2016","unstructured":"Taylor SE, Bagnall J, Mason D, Levy R, Fernig DG, See V (2016) Differential sub-nuclear distribution of hypoxia-inducible factors (HIF)-1 and -2 alpha impacts on their stability and mobility. Open Biol 6(9):160195. https:\/\/doi.org\/10.1098\/rsob.160195","journal-title":"Open Biol"},{"key":"974_CR78","first-page":"1014","volume":"7","author":"MM Thabet","year":"2006","unstructured":"Thabet MM, Huizinga TW (2006) Drug evaluation: apratastat, a novel TACE\/MMP inhibitor for rheumatoid arthritis. Curr Opin Invest Drugs 7:1014\u20131019","journal-title":"Curr Opin Invest Drugs"},{"issue":"Pt 1","key":"974_CR80","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1042\/bj3500307","volume":"350","author":"RD Thornton","year":"2000","unstructured":"Thornton RD, Lane P, Borghaei RC, Pease EA, Caro J, Mochan E (2000) Interleukin 1 induces hypoxia-inducible factor 1 in human gingival and synovial fibroblasts. Biochem J 350(Pt 1):307\u20133012. https:\/\/doi.org\/10.1042\/bj3500307","journal-title":"Biochem J"},{"key":"974_CR81","doi-asserted-by":"publisher","first-page":"3627","DOI":"10.1007\/s00018-019-03387-9","volume":"77","author":"JP Tolonen","year":"2020","unstructured":"Tolonen JP, Heikkila M, Malinen M, Lee HM, Palvimo JJ, Wei GH, Myllyharju J (2020) A long hypoxia-inducible factor 3 isoform 2 is a transcription activator that regulates erythropoietin. Cell Mol Life Sci 77:3627\u20133642","journal-title":"Cell Mol Life Sci"},{"key":"974_CR82","doi-asserted-by":"publisher","first-page":"1077","DOI":"10.1517\/14728222.2014.930440","volume":"18","author":"A Villalvilla","year":"2014","unstructured":"Villalvilla A, Gomez R, Roman-Blas JA, Largo R, Herrero-Beaumont G (2014) SDF-1 signaling: a promising target in rheumatic diseases. Expert Opin Ther Targets 18:1077\u20131087. https:\/\/doi.org\/10.1517\/14728222.2014.930440","journal-title":"Expert Opin Ther Targets"},{"key":"974_CR83","doi-asserted-by":"publisher","first-page":"3607","DOI":"10.1158\/1078-0432.CCR-07-2020","volume":"14","author":"Y Wang","year":"2008","unstructured":"Wang Y, Saad M, Pakunlu RI, Khandare JJ, Garbuzenko OB, Vetcher AA et al (2008) Nonviral nanoscale-based delivery of antisense oligonucleotides targeted to hypoxia-inducible factor 1 alpha enhances the efficacy of chemotherapy in drug-resistant tumor. Clin Cancer Res 14:3607\u20133616. https:\/\/doi.org\/10.1158\/1078-0432.CCR-07-2020","journal-title":"Clin Cancer Res"},{"key":"974_CR85","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1186\/1471-2474-11-61","volume":"11","author":"J Westra","year":"2010","unstructured":"Westra J, Brouwer E, van Roosmalen IA, Doornbos-van der Meer B, van Leeuwen MA, Posthumus MD et al (2010) Expression and regulation of HIF-1alpha in macrophages under inflammatory conditions; significant reduction of VEGF by CaMKII inhibitor. BMC Musculoskelet Disord 11:61. https:\/\/doi.org\/10.1186\/1471-2474-11-61","journal-title":"BMC Musculoskelet Disord"},{"key":"974_CR86","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2016.04.009","author":"C Wigerup","year":"2016","unstructured":"Wigerup C, P\u00e5hlman S, Bexell D (2016) Therapeutic targeting of hypoxia and hypoxia-inducible factors in cancer. Pharmacol Ther. https:\/\/doi.org\/10.1016\/j.pharmthera.2016.04.009","journal-title":"Pharmacol Ther"},{"key":"974_CR87","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1016\/j.ejmech.2012.01.033","volume":"49","author":"Y Xia","year":"2012","unstructured":"Xia Y, Choi H-K, Lee K (2012) (2012) Recent advances in hypoxia-inducible factor (HIF)-1 inhibitors. Eur J Med Chem 49:24\u201340","journal-title":"Eur J Med Chem"},{"key":"974_CR88","doi-asserted-by":"publisher","first-page":"10913","DOI":"10.1073\/pnas.0801898105","volume":"105","author":"D Xu","year":"2008","unstructured":"Xu D, Jiang HR, Kewin P, Li Y, Mu R, Fraser AR et al (2008) IL-33 exacerbates antigen-induced arthritis by activating mast cells. Proc Natl Acad Sci USA 105:10913\u201310918. https:\/\/doi.org\/10.1073\/pnas.0801898105","journal-title":"Proc Natl Acad Sci USA"},{"key":"974_CR89","doi-asserted-by":"publisher","first-page":"R170","DOI":"10.1186\/ar4357","volume":"15","author":"L Xu","year":"2013","unstructured":"Xu L, Feng X, Tan W, Gu W, Guo D, Zhang M et al (2013) IL-29 enhances Toll-like receptor-mediated IL-6 and IL-8 production by the synovial fibroblasts from rheumatoid arthritis patients. Arthritis Res Ther 15:R170. https:\/\/doi.org\/10.1186\/ar4357","journal-title":"Arthritis Res Ther"},{"key":"974_CR95","doi-asserted-by":"publisher","first-page":"174500","DOI":"10.1016\/j.ejphar.2021.174500","volume":"910","author":"W Yan","year":"2021","unstructured":"Yan W, Hong W, Ran D (2021) Angiogenesis as a potential treatment strategy for rheumatoid arthritis. Eur J Pharmacol 910:174500. https:\/\/doi.org\/10.1016\/j.ejphar.2021.174500","journal-title":"Eur J Pharmacol"},{"key":"974_CR100","doi-asserted-by":"publisher","first-page":"107993","DOI":"10.1016\/j.exer.2020.107993","volume":"193","author":"Y Yiyun","year":"2020","unstructured":"Yiyun Y, Yixuan Y, Anna MD, Ailing S, Ting S, Yanji Z, Xi S, Bing X (2020) Neutralization of Bombina variegata peptide 8 suppresses retinal neovascularization in two different murine models: the oxygen-induced retinopathy model and the rhodopsin promoter\/VEGF transgenic mouse model. Exp Eye Res 193:107993. https:\/\/doi.org\/10.1016\/j.exer.2020.107993","journal-title":"Exp Eye Res"},{"key":"974_CR101","doi-asserted-by":"publisher","DOI":"10.1007\/978-981-15-3984-8_14","author":"Z Yunhao","year":"2020","unstructured":"Yunhao Z, Janggun J, Guan X, Gandikota G, Elena S, Xueding W\n(2020) Application of LED-based photoacoustic imaging in diagnosis of human inflammatory arthritis, LED-based. Photoacoustic Imag. https:\/\/doi.org\/10.1007\/978-981-15-3984-8_14","journal-title":"Photoacoustic Imag"},{"key":"974_CR92","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1016\/j.jbspin.2014.10","volume":"82","author":"F-J Zhang","year":"2015","unstructured":"Zhang F-J, Luo W, Lei G-H (2015) Role of HIF-1\u03b1 and HIF-2\u03b1 in osteoarthritis. Jt Bone Spine 82:144\u2013147. https:\/\/doi.org\/10.1016\/j.jbspin.2014.10","journal-title":"Jt Bone Spine"}],"container-title":["Inflammopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10787-022-00974-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10787-022-00974-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10787-022-00974-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,26]],"date-time":"2022-05-26T12:25:22Z","timestamp":1653567922000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10787-022-00974-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4,1]]},"references-count":91,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2022,6]]}},"alternative-id":["974"],"URL":"https:\/\/doi.org\/10.1007\/s10787-022-00974-4","relation":{},"ISSN":["0925-4692","1568-5608"],"issn-type":[{"value":"0925-4692","type":"print"},{"value":"1568-5608","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,4,1]]},"assertion":[{"value":"25 January 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 March 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 April 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"None.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}},{"value":"Not Applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Not Applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to Participate"}},{"value":"All authors have given consent for publication of the current article.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to publish"}}]}}