{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T22:39:43Z","timestamp":1793227183943,"version":"4.5.0"},"reference-count":248,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2022,6,5]],"date-time":"2022-06-05T00:00:00Z","timestamp":1654387200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2022,6,5]],"date-time":"2022-06-05T00:00:00Z","timestamp":1654387200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Inflammopharmacol"],"published-print":{"date-parts":[[2022,10]]},"DOI":"10.1007\/s10787-022-01011-0","type":"journal-article","created":{"date-parts":[[2022,6,5]],"date-time":"2022-06-05T03:02:11Z","timestamp":1654398131000},"page":"1569-1596","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":83,"title":["Melatonin and multiple sclerosis: antioxidant, anti-inflammatory and immunomodulator mechanism of action"],"prefix":"10.1007","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7908-861X","authenticated-orcid":false,"given":"Ana","family":"Mu\u00f1oz-Jurado","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bego\u00f1a M.","family":"Escribano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier","family":"Caballero-Villarraso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"Galv\u00e1n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo","family":"Ag\u00fcera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abel","family":"Santamar\u00eda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4493-7087","authenticated-orcid":false,"given":"Isaac","family":"T\u00fanez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,6,5]]},"reference":[{"key":"1011_CR1","doi-asserted-by":"publisher","first-page":"386","DOI":"10.1007\/s12031-019-01425-6","volume":"70","author":"HA AboTaleb","year":"2020","unstructured":"AboTaleb HA, Alghamdi BS (2020) Neuroprotective effects of melatonin during demyelination and remyelination stages in a mouse model of multiple sclerosis. J Mol Neurosci 70:386\u2013402. https:\/\/doi.org\/10.1007\/s12031-019-01425-6","journal-title":"J Mol Neurosci"},{"key":"1011_CR2","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1034\/J.1600-079X.2001.300201.X","volume":"30","author":"D Acu\u00f1a-Castroviejo","year":"2001","unstructured":"Acu\u00f1a-Castroviejo D, Mart\u00edn M, Mac\u00edas M et al (2001) Melatonin, mitochondria, and cellular bioenergetics. J Pineal Res 30:65\u201374. https:\/\/doi.org\/10.1034\/J.1600-079X.2001.300201.X","journal-title":"J Pineal Res"},{"key":"1011_CR3","first-page":"235","volume":"67","author":"M Adamczyk-Sowa","year":"2016","unstructured":"Adamczyk-Sowa M, Sowa P, Adamczyk J et al (2016a) Effect of melatonin supplementation on plasma lipid hydroperoxides, homocysteine concentration and chronic fatigue syndrome in multiple sclerosis patients treated with interferons-beta and mitoxantrone. J Physiol Pharmacol 67:235\u2013242","journal-title":"J Physiol Pharmacol"},{"key":"1011_CR4","doi-asserted-by":"publisher","DOI":"10.12659\/MSM.895702","author":"M Adamczyk-Sowa","year":"2016","unstructured":"Adamczyk-Sowa M, Sowa P, Mucha S et al (2016) Changes in serum ceruloplasmin levels based on immunomodulatory treatments and melatonin supplementation in multiple sclerosis patients. Med Sci Monit. https:\/\/doi.org\/10.12659\/MSM.895702","journal-title":"Med Sci Monit"},{"key":"1011_CR5","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/7905148","author":"M Adamczyk-Sowa","year":"2017","unstructured":"Adamczyk-Sowa M, Galiniak S, Zyracka E et al (2017) Oxidative modification of blood serum proteins in multiple sclerosis after interferon beta and melatonin treatment. Oxid Med Cell Longev. https:\/\/doi.org\/10.1155\/2017\/7905148","journal-title":"Oxid Med Cell Longev"},{"key":"1011_CR6","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2020.00750","author":"E Ag\u00fcera","year":"2020","unstructured":"Ag\u00fcera E, Caballero-Villarraso J, Feij\u00f3o M et al (2020) Clinical and neurochemical effects of transcranial magnetic stimulation (TMS) in multiple sclerosis: a study protocol for a randomized clinical trial. Front Neurol. https:\/\/doi.org\/10.3389\/fneur.2020.00750","journal-title":"Front Neurol"},{"key":"1011_CR7","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1016\/j.psychres.2007.11.022","volume":"161","author":"Z Akpinar","year":"2008","unstructured":"Akpinar Z, Tokg\u00f6z S, G\u00f6kbel H et al (2008) The association of nocturnal serum melatonin levels with major depression in patients with acute multiple sclerosis. Psychiatry Res 161:253\u2013257. https:\/\/doi.org\/10.1016\/j.psychres.2007.11.022","journal-title":"Psychiatry Res"},{"key":"1011_CR8","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchemneu.2020.101902","author":"A Albazal","year":"2021","unstructured":"Albazal A, Delshad AA, Roghani M (2021) Melatonin reverses cognitive deficits in streptozotocin-induced type 1 diabetes in the rat through attenuation of oxidative stress and inflammation. J Chem Neuroanat. https:\/\/doi.org\/10.1016\/j.jchemneu.2020.101902","journal-title":"J Chem Neuroanat"},{"key":"1011_CR9","doi-asserted-by":"publisher","first-page":"229","DOI":"10.31083\/j.jin.2020.02.32","volume":"19","author":"BS Alghamdi","year":"2020","unstructured":"Alghamdi BS, AboTaleb HA (2020) Melatonin improves memory defects in a mouse model of multiple sclerosis by up-regulating cAMP-response element-binding protein and synapse-associated proteins in the prefrontal cortex. J Integr Neurosci 19:229\u2013237. https:\/\/doi.org\/10.31083\/j.jin.2020.02.32","journal-title":"J Integr Neurosci"},{"key":"1011_CR10","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1016\/j.bbi.2015.06.021","volume":"50","author":"N \u00c1lvarez-S\u00e1nchez","year":"2015","unstructured":"\u00c1lvarez-S\u00e1nchez N, Cruz-Chamorro I, L\u00f3pez-Gonz\u00e1lez A et al (2015) Melatonin controls experimental autoimmune encephalomyelitis by altering the T effector\/regulatory balance. Brain Behav Immun 50:101\u2013114. https:\/\/doi.org\/10.1016\/j.bbi.2015.06.021","journal-title":"Brain Behav Immun"},{"key":"1011_CR11","doi-asserted-by":"publisher","DOI":"10.1111\/jpi.12442","author":"N \u00c1lvarez-S\u00e1nchez","year":"2017","unstructured":"\u00c1lvarez-S\u00e1nchez N, Cruz-Chamorro I, D\u00edaz-S\u00e1nchez M et al (2017) Melatonin reduces inflammatory response in peripheral T helper lymphocytes from relapsing-remitting multiple sclerosis patients. J Pineal Res. https:\/\/doi.org\/10.1111\/jpi.12442","journal-title":"J Pineal Res"},{"key":"1011_CR12","doi-asserted-by":"publisher","DOI":"10.1002\/rmv.2109","author":"G Anderson","year":"2020","unstructured":"Anderson G, Reiter RJ (2020) Melatonin: roles in influenza, Covid-19, and other viral infections. Rev Med Virol. https:\/\/doi.org\/10.1002\/rmv.2109","journal-title":"Rev Med Virol"},{"issue":"21","key":"1011_CR13","doi-asserted-by":"publisher","first-page":"5500","DOI":"10.3390\/ijms20215500","volume":"20","author":"G Anderson","year":"2019","unstructured":"Anderson G, Rodriguez M, Reiter RJ (2019) Multiple sclerosis: melatonin, orexin, and ceramide interact with platelet activation coagulation factors and gut-microbiome-derived butyrate in the circadian dysregulation of mitochondria in glia and immune cells. Int J Mol Sci 20(21):5500. https:\/\/doi.org\/10.3390\/ijms20215500","journal-title":"Int J Mol Sci"},{"key":"1011_CR14","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3390\/biology9090249","volume":"9","author":"G Anderson","year":"2020","unstructured":"Anderson G, Carbone A, Mazzoccoli G (2020) Aryl hydrocarbon receptor role in co-ordinating sars-cov-2 entry and symptomatology: linking cytotoxicity changes in covid-19 and cancers; modulation by racial discrimination stress. Biology (basel) 9:1\u201331. https:\/\/doi.org\/10.3390\/biology9090249","journal-title":"Biology (basel)"},{"issue":"12 Suppl","key":"1011_CR15","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1586\/14737175.2013.865866","volume":"13","author":"A Ascherio","year":"2013","unstructured":"Ascherio A (2013) Environmental factors in multiple sclerosis. Expert Rev Neurother 13(12 Suppl):3\u20139. https:\/\/doi.org\/10.1586\/14737175.2013.865866","journal-title":"Expert Rev Neurother"},{"key":"1011_CR16","doi-asserted-by":"publisher","first-page":"599","DOI":"10.1016\/S1474-4422(10)70086-7","volume":"9","author":"A Ascherio","year":"2010","unstructured":"Ascherio A, Munger KL, Simon KC (2010) Vitamin D and multiple sclerosis. Lancet Neurol 9:599\u2013612","journal-title":"Lancet Neurol"},{"key":"1011_CR17","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1159\/000494262","volume":"80","author":"M Avila","year":"2018","unstructured":"Avila M, Bansal A, Culberson J, Peiris ANN (2018) The role of sex hormones in multiple sclerosis. Eur Neurol 80:93\u201399. https:\/\/doi.org\/10.1159\/000494262","journal-title":"Eur Neurol"},{"key":"1011_CR18","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1016\/j.jneuroim.2005.07.001","volume":"167","author":"D Azoulay","year":"2005","unstructured":"Azoulay D, Vachapova V, Shihman B et al (2005) Lower brain-derived neurotrophic factor in serum of relapsing remitting MS: reversal by glatiramer acetate. J Neuroimmunol 167:215\u2013218. https:\/\/doi.org\/10.1016\/j.jneuroim.2005.07.001","journal-title":"J Neuroimmunol"},{"key":"1011_CR19","doi-asserted-by":"publisher","first-page":"186","DOI":"10.1016\/j.jneuroim.2008.01.010","volume":"195","author":"D Azoulay","year":"2008","unstructured":"Azoulay D, Urshansky N, Karni A (2008) Low and dysregulated BDNF secretion from immune cells of MS patients is related to reduced neuroprotection. J Neuroimmunol 195:186\u2013193. https:\/\/doi.org\/10.1016\/j.jneuroim.2008.01.010","journal-title":"J Neuroimmunol"},{"key":"1011_CR20","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1016\/j.ejphar.2014.02.020","volume":"730","author":"C Bahamonde","year":"2014","unstructured":"Bahamonde C, Conde C, Ag\u00fcera E et al (2014) Elevated melatonin levels in natalizumab-treated female patients with relapsing-remitting multiple sclerosis: relationship to oxidative stress. Eur J Pharmacol 730:26\u201330. https:\/\/doi.org\/10.1016\/j.ejphar.2014.02.020","journal-title":"Eur J Pharmacol"},{"key":"1011_CR21","doi-asserted-by":"publisher","first-page":"981","DOI":"10.3390\/ijms18050981","volume":"18","author":"V Basoli","year":"2017","unstructured":"Basoli V, Santaniello S, Cruciani S et al (2017) Melatonin and vitamin D interfere with the adipogenic fate of adipose-derived stem cells. Int J Mol Sci 18:981. https:\/\/doi.org\/10.3390\/ijms18050981","journal-title":"Int J Mol Sci"},{"key":"1011_CR22","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2019.e01190","author":"N Beriwal","year":"2019","unstructured":"Beriwal N, Namgyal T, Sangay P, Al Quraan AM (2019) Role of immune-pineal axis in neurodegenerative diseases, unraveling novel hybrid dark hormone therapies. Heliyon. https:\/\/doi.org\/10.1016\/j.heliyon.2019.e01190","journal-title":"Heliyon"},{"key":"1011_CR23","doi-asserted-by":"publisher","DOI":"10.1177\/1352458517737396","author":"R Bove","year":"2018","unstructured":"Bove R, Gilmore W (2018) Hormones and MS: Risk factors, biomarkers, and therapeutic targets. Mult Scler. https:\/\/doi.org\/10.1177\/1352458517737396","journal-title":"Mult Scler"},{"key":"1011_CR24","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-030-24436-1_10","author":"MJ Bradshaw","year":"2020","unstructured":"Bradshaw MJ, Holick MF, Stankiewicz JM (2020) Vitamin D and multiple sclerosis. Curr Clin Neurol. https:\/\/doi.org\/10.1007\/978-3-030-24436-1_10","journal-title":"Curr Clin Neurol"},{"key":"1011_CR25","doi-asserted-by":"publisher","first-page":"1900","DOI":"10.1093\/brain\/awy131","volume":"141","author":"CR Camara-Lemarroy","year":"2018","unstructured":"Camara-Lemarroy CR, Metz L, Meddings JB et al (2018) The intestinal barrier in multiple sclerosis: implications for pathophysiology and therapeutics. Brain 141:1900\u20131916. https:\/\/doi.org\/10.1093\/brain\/awy131","journal-title":"Brain"},{"key":"1011_CR26","doi-asserted-by":"publisher","DOI":"10.4061\/2011\/262847","author":"GR Campbell","year":"2011","unstructured":"Campbell GR, Mahad DJ (2011) Mitochondria as crucial players in demyelinated axons: lessons from neuropathology and experimental demyelination. Autoimmune Dis. https:\/\/doi.org\/10.4061\/2011\/262847","journal-title":"Autoimmune Dis"},{"key":"1011_CR27","doi-asserted-by":"publisher","DOI":"10.1002\/ana.22109","author":"GR Campbell","year":"2011","unstructured":"Campbell GR, Ziabreva I, Reeve AK et al (2011) Mitochondrial DNA deletions and neurodegeneration in multiple sclerosis. Ann Neurol. https:\/\/doi.org\/10.1002\/ana.22109","journal-title":"Ann Neurol"},{"key":"1011_CR28","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2019.00480","author":"DP Cardinali","year":"2019","unstructured":"Cardinali DP (2019) Melatonin: clinical perspectives in neurodegeneration. Front Endocrinol (Lausanne). https:\/\/doi.org\/10.3389\/fendo.2019.00480","journal-title":"Front Endocrinol (Lausanne)"},{"key":"1011_CR29","doi-asserted-by":"publisher","first-page":"1563","DOI":"10.2174\/1381612824666180426112832","volume":"24","author":"L Carrascal","year":"2018","unstructured":"Carrascal L, Nunez-Abades P, Ayala A, Cano M (2018) Role of melatonin in the inflammatory process and its therapeutic potential. Curr Pharm Des 24:1563\u20131588. https:\/\/doi.org\/10.2174\/1381612824666180426112832","journal-title":"Curr Pharm Des"},{"key":"1011_CR30","doi-asserted-by":"publisher","first-page":"400","DOI":"10.1111\/j.1600-079X.2005.00265.x","volume":"39","author":"A Carrillo-Vico","year":"2005","unstructured":"Carrillo-Vico A, Lardone PJ, Naji L et al (2005) Beneficial pleiotropic actions of melatonin in an experimental model of septic shock in mice: regulation of pro-\/anti-inflammatory cytokine network, protection against oxidative damage and anti-apoptotic effects. J Pineal Res 39:400\u2013408. https:\/\/doi.org\/10.1111\/j.1600-079X.2005.00265.x","journal-title":"J Pineal Res"},{"key":"1011_CR31","doi-asserted-by":"publisher","first-page":"1425","DOI":"10.1177\/1352458514533400","volume":"20","author":"AN Carvalho","year":"2014","unstructured":"Carvalho AN, Lim JL, Nijland PG et al (2014) Glutathione in multiple sclerosis: more than just an antioxidant? Mult Scler J 20:1425\u20131431. https:\/\/doi.org\/10.1177\/1352458514533400","journal-title":"Mult Scler J"},{"key":"1011_CR32","doi-asserted-by":"publisher","first-page":"1227","DOI":"10.1111\/j.1471-4159.2005.03457.x","volume":"95","author":"LMR Castro","year":"2005","unstructured":"Castro LMR, Gallant M, Niles LP (2005) Novel targets for valproic acid: up-regulation of melatonin receptors and neurotrophic factors in C6 glioma cells. J Neurochem 95:1227\u20131236. https:\/\/doi.org\/10.1111\/j.1471-4159.2005.03457.x","journal-title":"J Neurochem"},{"key":"1011_CR33","doi-asserted-by":"publisher","first-page":"312","DOI":"10.1111\/J.1600-079X.2011.00945.X","volume":"52","author":"C Chang","year":"2012","unstructured":"Chang C, Huang H, Lee H et al (2012) Melatonin attenuates kainic acid-induced neurotoxicity in mouse hippocampus via inhibition of autophagy and \u03b1-synuclein aggregation. J Pineal Res 52:312\u2013321. https:\/\/doi.org\/10.1111\/J.1600-079X.2011.00945.X","journal-title":"J Pineal Res"},{"key":"1011_CR34","doi-asserted-by":"publisher","first-page":"21147","DOI":"10.18632\/aging.103785","volume":"12","author":"T Chang","year":"2020","unstructured":"Chang T, Niu C, Sun C et al (2020) Melatonin exerts immunoregulatory effects by balancing peripheral effector and regulatory T helper cells in myasthenia gravis. Aging (Albany NY) 12:21147\u201321160. https:\/\/doi.org\/10.18632\/aging.103785","journal-title":"Aging (Albany NY)"},{"key":"1011_CR35","doi-asserted-by":"publisher","DOI":"10.1038\/srep28484","author":"J Chen","year":"2016","unstructured":"Chen J, Chia N, Kalari KR et al (2016) Multiple sclerosis patients have a distinct gut microbiota compared to healthy controls. Sci Rep. https:\/\/doi.org\/10.1038\/srep28484","journal-title":"Sci Rep"},{"key":"1011_CR36","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3390\/biom10081158","volume":"10","author":"D Chen","year":"2020","unstructured":"Chen D, Zhang T, Lee TH (2020) Cellular mechanisms of melatonin: Insight from neurodegenerative diseases. Biomolecules 10:1\u201326. https:\/\/doi.org\/10.3390\/biom10081158","journal-title":"Biomolecules"},{"key":"1011_CR37","doi-asserted-by":"publisher","first-page":"63","DOI":"10.4449\/aib.v144i2.882","volume":"144","author":"V Chisu","year":"2006","unstructured":"Chisu V, Manca P, Lepore G et al (2006) Testosterone induces neuroprotection from oxidative stress. Effects on catalase activity and 3-nitro-L-tyrosine incorporation into \u03b1-tubulin in a mouse neuroblastoma cell line. Arch Ital Biol 144:63\u201373. https:\/\/doi.org\/10.4449\/aib.v144i2.882","journal-title":"Arch Ital Biol"},{"key":"1011_CR38","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3390\/biom10091211","volume":"10","author":"DM Chitimus","year":"2020","unstructured":"Chitimus DM, Popescu MR, Voiculescu SE et al (2020) Melatonin\u2019s impact on antioxidative and anti-inflammatory reprogramming in homeostasis and disease. Biomolecules 10:1\u201328. https:\/\/doi.org\/10.3390\/biom10091211","journal-title":"Biomolecules"},{"key":"1011_CR39","doi-asserted-by":"publisher","first-page":"192","DOI":"10.1016\/J.CLIM.2013.03.014","volume":"149","author":"T Chitnis","year":"2013","unstructured":"Chitnis T (2013) Role of puberty in multiple sclerosis risk and course. Clin Immunol 149:192\u2013200. https:\/\/doi.org\/10.1016\/J.CLIM.2013.03.014","journal-title":"Clin Immunol"},{"key":"1011_CR40","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1016\/J.NEUCHI.2015.03.002","volume":"61","author":"B Claustrat","year":"2015","unstructured":"Claustrat B, Leston J (2015) Melatonin: physiological effects in humans. Neurochirurgie 61:77\u201384. https:\/\/doi.org\/10.1016\/J.NEUCHI.2015.03.002","journal-title":"Neurochirurgie"},{"key":"1011_CR41","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1016\/j.smrv.2004.08.001","volume":"9","author":"B Claustrat","year":"2005","unstructured":"Claustrat B, Brun J, Chazot G (2005) The basic physiology and pathophysiology of melatonin. Sleep Med Rev 9:11\u201324. https:\/\/doi.org\/10.1016\/j.smrv.2004.08.001","journal-title":"Sleep Med Rev"},{"key":"1011_CR42","doi-asserted-by":"publisher","first-page":"495","DOI":"10.2174\/1570159x14666160330105132","volume":"15","author":"S Cobianchi","year":"2016","unstructured":"Cobianchi S, Arbat-Plana A, Lopez-Alvarez VM, Navarro X (2016) Neuroprotective effects of exercise treatments after injury: the dual role of neurotrophic factors. Curr Neuropharmacol 15:495\u2013518. https:\/\/doi.org\/10.2174\/1570159x14666160330105132","journal-title":"Curr Neuropharmacol"},{"issue":"1","key":"1011_CR43","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1503\/jpn.130009","volume":"39","author":"S Comai","year":"2014","unstructured":"Comai S, Gobbi G (2014) Unveiling the role of melatonin MT2 receptors in sleep, anxiety and other neuropsychiatric diseases: a novel target in psychopharmacology. J Psychiatry Neurosci 39(1):6\u201321. https:\/\/doi.org\/10.1503\/jpn.130009","journal-title":"J Psychiatry Neurosci"},{"key":"1011_CR44","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1590\/S0100-879X2011007500165","volume":"45","author":"ER Comini-Frota","year":"2012","unstructured":"Comini-Frota ER, Rodrigues DH, Miranda EC et al (2012) Serum levels of brain-derived neurotrophic factor correlate with the number of T2 MRI lesions in multiple sclerosis. Brazilian J Med Biol Res 45:68\u201371. https:\/\/doi.org\/10.1590\/S0100-879X2011007500165","journal-title":"Brazilian J Med Biol Res"},{"key":"1011_CR45","doi-asserted-by":"publisher","first-page":"1221","DOI":"10.1016\/S0140-6736(02)08220-X","volume":"359","author":"A Compston","year":"2002","unstructured":"Compston A, Coles A (2002) Multiple sclerosis. Lancet 359:1221\u20131231. https:\/\/doi.org\/10.1016\/S0140-6736(02)08220-X","journal-title":"Lancet"},{"key":"1011_CR46","doi-asserted-by":"publisher","first-page":"1502","DOI":"10.1016\/S0140-6736(08)61620-7","volume":"372","author":"A Compston","year":"2008","unstructured":"Compston A, Coles A (2008) Multiple sclerosis. Lancet 372:1502\u20131517. https:\/\/doi.org\/10.1016\/S0140-6736(08)61620-7","journal-title":"Lancet"},{"key":"1011_CR47","doi-asserted-by":"publisher","DOI":"10.3390\/nu11102448","author":"C Conde","year":"2019","unstructured":"Conde C, Escribano BM, Luque E et al (2019) Extra-virgin olive oil modifies the changes induced in non-nervous organs and tissues by experimental autoimmune encephalomyelitis models. Nutrients. https:\/\/doi.org\/10.3390\/nu11102448","journal-title":"Nutrients"},{"key":"1011_CR48","doi-asserted-by":"publisher","DOI":"10.1159\/000164122","author":"CS Constantinescu","year":"1997","unstructured":"Constantinescu CS, Hilliard B, Ventura E, Rostami A (1997) Luzindole, a melatonin receptor antagonist, suppresses experimental autoimmune encephalomyelitis. Pathobiology. https:\/\/doi.org\/10.1159\/000164122","journal-title":"Pathobiology"},{"key":"1011_CR49","doi-asserted-by":"publisher","DOI":"10.1111\/jpi.12335","author":"I Crespo","year":"2016","unstructured":"Crespo I, San-Miguel B, S\u00e1nchez DI et al (2016) Melatonin inhibits the sphingosine kinase 1\/sphingosine-1-phosphate signaling pathway in rabbits with fulminant hepatitis of viral origin. J Pineal Res. https:\/\/doi.org\/10.1111\/jpi.12335","journal-title":"J Pineal Res"},{"key":"1011_CR50","doi-asserted-by":"publisher","first-page":"1201","DOI":"10.1016\/0896-6273(95)90267-8","volume":"14","author":"R Curtis","year":"1995","unstructured":"Curtis R, Adryan KM, Stark JL et al (1995) Differential role of the low affinity neurotrophin receptor (p75) in retrograde axonal transport of the neurotrophins. Neuron 14:1201\u20131211. https:\/\/doi.org\/10.1016\/0896-6273(95)90267-8","journal-title":"Neuron"},{"key":"1011_CR51","doi-asserted-by":"publisher","first-page":"825","DOI":"10.1016\/S0889-857X(05)70171-X","volume":"26","author":"M Cutolo","year":"2000","unstructured":"Cutolo M, Wilder RL (2000) Different roles for androgens and estrogens in the susceptibility to autoimmune rheumatic diseases. Rheum Dis Clin North Am 26:825\u2013839. https:\/\/doi.org\/10.1016\/S0889-857X(05)70171-X","journal-title":"Rheum Dis Clin North Am"},{"key":"1011_CR52","doi-asserted-by":"publisher","DOI":"10.1177\/1759091420981204","author":"R Das","year":"2020","unstructured":"Das R, Balmik AA, Chinnathambi S (2020) Melatonin reduces GSK3\u03b2-mediated Tau phosphorylation, enhances Nrf2 nuclear translocation and anti-inflammation. ASN Neuro. https:\/\/doi.org\/10.1177\/1759091420981204","journal-title":"ASN Neuro"},{"key":"1011_CR53","doi-asserted-by":"publisher","first-page":"e12502","DOI":"10.1111\/jne.12502","volume":"30","author":"AF De Nicola","year":"2018","unstructured":"De Nicola AF, Garay LI, Meyer M et al (2018) Neurosteroidogenesis and progesterone anti-inflammatory\/neuroprotective effects. J Neuroendocrinol 30:e12502. https:\/\/doi.org\/10.1111\/jne.12502","journal-title":"J Neuroendocrinol"},{"issue":"Suppl","key":"1011_CR54","doi-asserted-by":"publisher","first-page":"S111","DOI":"10.1002\/ANA.410320719","volume":"32","author":"D Di Monte","year":"1992","unstructured":"Di Monte D, Chan P, Sandy M (1992) Glutathione in Parkinson\u2019s disease: a link between oxidative stress and mitochondrial damage? Ann Neurol 32(Suppl):S111\u2013S115. https:\/\/doi.org\/10.1002\/ANA.410320719","journal-title":"Ann Neurol"},{"key":"1011_CR55","doi-asserted-by":"publisher","DOI":"10.1016\/j.msard.2020.102540","author":"A Di Stadio","year":"2020","unstructured":"Di Stadio A, Romani L, Bernitsas E (2020) Could sars-Cov2 affect MS progression? Mult Scler Relat Disord. https:\/\/doi.org\/10.1016\/j.msard.2020.102540","journal-title":"Mult Scler Relat Disord"},{"key":"1011_CR56","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s42003-021-01669-2","volume":"4","author":"V Diez","year":"2021","unstructured":"Diez V, Traikov S, Schmeisser K et al (2021) Glycolate combats massive oxidative stress by restoring redox potential in caenorhabditis elegans. Commun Biol 4:1\u201313. https:\/\/doi.org\/10.1038\/s42003-021-01669-2","journal-title":"Commun Biol"},{"key":"1011_CR57","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2020.110827","author":"Z Ding","year":"2020","unstructured":"Ding Z, Wu X, Wang Y et al (2020) Melatonin prevents LPS-induced epithelial-mesenchymal transition in human alveolar epithelial cells via the GSK-3\u03b2\/Nrf2 pathway. Biomed Pharmacother. https:\/\/doi.org\/10.1016\/j.biopha.2020.110827","journal-title":"Biomed Pharmacother"},{"key":"1011_CR58","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1016\/J.MRFMMM.2005.01.033","volume":"591","author":"M Dizdaroglu","year":"2005","unstructured":"Dizdaroglu M (2005) Base-excision repair of oxidative DNA damage by DNA glycosylases. Mutat Res 591:45\u201359. https:\/\/doi.org\/10.1016\/J.MRFMMM.2005.01.033","journal-title":"Mutat Res"},{"key":"1011_CR59","doi-asserted-by":"publisher","first-page":"356","DOI":"10.1016\/j.ecoenv.2018.07.089","volume":"163","author":"J Duan","year":"2018","unstructured":"Duan J, Kang J, Qin W et al (2018) Exposure to formaldehyde and diisononyl phthalate exacerbate neuroinflammation through NF-\u03baB activation in a mouse asthma model. Ecotoxicol Environ Saf 163:356\u2013364. https:\/\/doi.org\/10.1016\/j.ecoenv.2018.07.089","journal-title":"Ecotoxicol Environ Saf"},{"key":"1011_CR60","doi-asserted-by":"publisher","DOI":"10.1186\/s13293-021-00358-3","author":"ML Dupuis","year":"2021","unstructured":"Dupuis ML, Pagano MT, Pierdominici M, Ortona E (2021) The role of vitamin D in autoimmune diseases: could sex make the difference? Biol Sex Differ. https:\/\/doi.org\/10.1186\/s13293-021-00358-3","journal-title":"Biol Sex Differ"},{"key":"1011_CR61","doi-asserted-by":"publisher","DOI":"10.1016\/j.msard.2020.102732","author":"K El-Salem","year":"2021","unstructured":"El-Salem K, Khalil H, Al-Sharman A et al (2021) Serum vitamin d inversely correlates with depression scores in people with multiple sclerosis. Mult Scler Relat Disord. https:\/\/doi.org\/10.1016\/j.msard.2020.102732","journal-title":"Mult Scler Relat Disord"},{"key":"1011_CR62","doi-asserted-by":"publisher","first-page":"1096","DOI":"10.2174\/1871527313666140806160400","volume":"13","author":"BM Escribano","year":"2014","unstructured":"Escribano BM, Colin-Gonzalez A, Santamaria A, Tunez I (2014) The role of melatonin in multiple sclerosis, Huntington\u2019s disease and cerebral ischemia. CNS Neurol Disord - Drug Targets 13:1096\u20131119. https:\/\/doi.org\/10.2174\/1871527313666140806160400","journal-title":"CNS Neurol Disord - Drug Targets"},{"key":"1011_CR63","doi-asserted-by":"publisher","DOI":"10.1007\/s13311-016-0480-0","author":"BM Escribano","year":"2017","unstructured":"Escribano BM, Medina-Fern\u00e1ndez FJ, Aguilar-Luque M et al (2017) Lipopolysaccharide binding protein and oxidative stress in a multiple sclerosis model. Neurotherapeutics. https:\/\/doi.org\/10.1007\/s13311-016-0480-0","journal-title":"Neurotherapeutics"},{"key":"1011_CR64","doi-asserted-by":"publisher","first-page":"103520","DOI":"10.1016\/J.MSARD.2022.103520","volume":"58","author":"BM Escribano","year":"2022","unstructured":"Escribano BM, Mu\u00f1oz-Jurado A, Caballero-Villarraso J et al (2022) Protective effects of melatonin on changes occurring in the experimental autoimmune encephalomyelitis model of multiple sclerosis. Mult Scler Relat Disord 58:103520. https:\/\/doi.org\/10.1016\/J.MSARD.2022.103520","journal-title":"Mult Scler Relat Disord"},{"key":"1011_CR65","doi-asserted-by":"publisher","first-page":"228","DOI":"10.2174\/157015910792246155","volume":"8","author":"E Esposito","year":"2010","unstructured":"Esposito E, Cuzzocrea S (2010) Antiinflammatory activity of melatonin in central nervous system. Curr Neuropharmacol 8:228\u2013242. https:\/\/doi.org\/10.2174\/157015910792246155","journal-title":"Curr Neuropharmacol"},{"key":"1011_CR66","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1007\/s12640-015-9544-x","volume":"28","author":"C Estrada","year":"2015","unstructured":"Estrada C, L\u00f3pez D, Conesa A et al (2015) Cognitive impairment after sleep deprivation rescued by transcranial magnetic stimulation application in octodon degus. Neurotox Res 28:361\u2013371. https:\/\/doi.org\/10.1007\/s12640-015-9544-x","journal-title":"Neurotox Res"},{"key":"1011_CR67","doi-asserted-by":"publisher","first-page":"905","DOI":"10.1038\/s41573-019-0035-2","volume":"18","author":"S Faissner","year":"2019","unstructured":"Faissner S, Plemel JR, Gold R, Yong VW (2019) Progressive multiple sclerosis: from pathophysiology to therapeutic strategies. Nat Rev Drug Discov 18:905\u2013922. https:\/\/doi.org\/10.1038\/s41573-019-0035-2","journal-title":"Nat Rev Drug Discov"},{"key":"1011_CR68","doi-asserted-by":"publisher","first-page":"1338","DOI":"10.1016\/j.cell.2015.08.025","volume":"162","author":"MF Farez","year":"2015","unstructured":"Farez MF, Mascanfroni ID, M\u00e9ndez-Huergo SP et al (2015) Melatonin contributes to the seasonality of multiple sclerosis relapses. Cell 162:1338\u20131352. https:\/\/doi.org\/10.1016\/j.cell.2015.08.025","journal-title":"Cell"},{"key":"1011_CR69","doi-asserted-by":"publisher","first-page":"1016","DOI":"10.1002\/bies.201600018","volume":"38","author":"MF Farez","year":"2016","unstructured":"Farez MF, Calandri IL, Correale J, Quintana FJ (2016) Anti-inflammatory effects of melatonin in multiple sclerosis. BioEssays 38:1016\u20131026. https:\/\/doi.org\/10.1002\/bies.201600018","journal-title":"BioEssays"},{"key":"1011_CR70","doi-asserted-by":"publisher","DOI":"10.3389\/fvets.2020.585789","author":"S Fatima","year":"2020","unstructured":"Fatima S, Zaidi SS, Alsharidah AS et al (2020) Possible prophylactic approach for SARS-CoV-2 infection by combination of melatonin, vitamin C and Zinc in animals. Front Vet Sci. https:\/\/doi.org\/10.3389\/fvets.2020.585789","journal-title":"Front Vet Sci"},{"key":"1011_CR71","doi-asserted-by":"publisher","first-page":"1395","DOI":"10.4161\/AUTO.25468","volume":"9","author":"Y Feng","year":"2013","unstructured":"Feng Y, Jia Y, Su L et al (2013) Decreased mitochondrial DNA copy number in the hippocampus and peripheral blood during opiate addiction is mediated by autophagy and can be salvaged by melatonin. Autophagy 9:1395\u20131406. https:\/\/doi.org\/10.4161\/AUTO.25468","journal-title":"Autophagy"},{"key":"1011_CR72","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2021.111428","author":"YS Feng","year":"2021","unstructured":"Feng YS, Tan ZX, Wu LY et al (2021) The involvement of NLRP3 inflammasome in the treatment of neurodegenerative diseases. Biomed Pharmacother. https:\/\/doi.org\/10.1016\/j.biopha.2021.111428","journal-title":"Biomed Pharmacother"},{"key":"1011_CR73","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3390\/antiox9121187","volume":"9","author":"M Fern\u00e1ndez-Ortiz","year":"2020","unstructured":"Fern\u00e1ndez-Ortiz M, Sayed RKA, Fern\u00e1ndez-Mart\u00ednez J et al (2020) Melatonin\/Nrf2\/NLRP3 connection in mouse heart mitochondria during aging. Antioxidants 9:1\u201322. https:\/\/doi.org\/10.3390\/antiox9121187","journal-title":"Antioxidants"},{"key":"1011_CR74","doi-asserted-by":"publisher","DOI":"10.1128\/mcb.01191-13","author":"T Fukutomi","year":"2014","unstructured":"Fukutomi T, Takagi K, Mizushima T et al (2014) Kinetic, thermodynamic, and structural characterizations of the association between Nrf2-DLGex degron and keap1. Mol Cell Biol. https:\/\/doi.org\/10.1128\/mcb.01191-13","journal-title":"Mol Cell Biol"},{"key":"1011_CR75","doi-asserted-by":"publisher","first-page":"3863","DOI":"10.1096\/fj.15-273656","volume":"29","author":"JA Garc\u00eda","year":"2015","unstructured":"Garc\u00eda JA, Volt H, Venegas C et al (2015) Disruption of the NF-\u03baB\/NLRP3 connection by melatonin requires retinoid-related orphan receptor-a and blocks the septic response in mice. FASEB J 29:3863\u20133875. https:\/\/doi.org\/10.1096\/fj.15-273656","journal-title":"FASEB J"},{"key":"1011_CR76","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1111\/1440-1681.12678","volume":"44","author":"M Ghareghani","year":"2017","unstructured":"Ghareghani M, Dokoohaki S, Ghanbari A et al (2017a) Melatonin exacerbates acute experimental autoimmune encephalomyelitis by enhancing the serum levels of lactate: a potential biomarker of multiple sclerosis progression. Clin Exp Pharmacol Physiol 44:52\u201361. https:\/\/doi.org\/10.1111\/1440-1681.12678","journal-title":"Clin Exp Pharmacol Physiol"},{"key":"1011_CR77","doi-asserted-by":"publisher","first-page":"1319","DOI":"10.1007\/S10571-016-0450-4","volume":"37","author":"M Ghareghani","year":"2017","unstructured":"Ghareghani M, Sadeghi H, Zibara K et al (2017b) Melatonin increases oligodendrocyte differentiation in cultured neural stem cells. Cell Mol Neurobiol 37:1319\u20131324. https:\/\/doi.org\/10.1007\/S10571-016-0450-4","journal-title":"Cell Mol Neurobiol"},{"key":"1011_CR78","doi-asserted-by":"publisher","first-page":"2484","DOI":"10.3389\/fimmu.2018.02484","volume":"9","author":"M Ghareghani","year":"2018","unstructured":"Ghareghani M, Reiter RJ, Zibara K, Farhadi N (2018) Latitude, vitamin D, melatonin, and gut microbiota act in concert to initiate multiple sclerosis: a new mechanistic pathway. Front Immunol 9:2484. https:\/\/doi.org\/10.3389\/fimmu.2018.02484","journal-title":"Front Immunol"},{"key":"1011_CR79","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2019.00147","author":"M Ghareghani","year":"2019","unstructured":"Ghareghani M, Scavo L, Jand Y et al (2019) Melatonin therapy modulates cerebral metabolism and enhances remyelination by increasing PDK4 in a mouse model of multiple sclerosis. Front Pharmacol. https:\/\/doi.org\/10.3389\/fphar.2019.00147","journal-title":"Front Pharmacol"},{"key":"1011_CR80","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1159\/000097258","volume":"13","author":"A Giannoulia-Karantana","year":"2007","unstructured":"Giannoulia-Karantana A, Vlachou A, Polychronopoulou S et al (2007) Melatonin and immunomodulation: connections and potential clinical applications. NeuroImmunoModulation 13:133\u2013144. https:\/\/doi.org\/10.1159\/000097258","journal-title":"NeuroImmunoModulation"},{"key":"1011_CR81","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1007\/s12026-007-0069-0","volume":"39","author":"TL Gioannini","year":"2007","unstructured":"Gioannini TL, Weiss JP (2007) Regulation of interactions of Gram-negative bacterial endotoxins with mammalian cells. Immunol Res 39:249\u2013260. https:\/\/doi.org\/10.1007\/s12026-007-0069-0","journal-title":"Immunol Res"},{"key":"1011_CR82","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2013.04.010","author":"D Golan","year":"2013","unstructured":"Golan D, Staun-Ram E, Glass-Marmor L et al (2013) The influence of vitamin D supplementation on melatonin status in patients with multiple sclerosis. Brain Behav Immun. https:\/\/doi.org\/10.1016\/j.bbi.2013.04.010","journal-title":"Brain Behav Immun"},{"key":"1011_CR83","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1016\/S0079-6123(09)17516-7","volume":"175","author":"SM Gold","year":"2009","unstructured":"Gold SM, Voskuhl RR (2009) Estrogen and testosterone therapies in multiple sclerosis. Prog Brain Res 175:239\u2013251. https:\/\/doi.org\/10.1016\/S0079-6123(09)17516-7","journal-title":"Prog Brain Res"},{"key":"1011_CR84","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1016\/S0165-5728(03)00121-8","volume":"138","author":"SM Gold","year":"2003","unstructured":"Gold SM, Schulz KH, Hartmann S et al (2003) Basal serum levels and reactivity of nerve growth factor and brain-derived neurotrophic factor to standardized acute exercise in multiple sclerosis and controls. J Neuroimmunol 138:99\u2013105. https:\/\/doi.org\/10.1016\/S0165-5728(03)00121-8","journal-title":"J Neuroimmunol"},{"key":"1011_CR85","first-page":"175","volume":"37","author":"MM Goldenberg","year":"2012","unstructured":"Goldenberg MM (2012) Multiple sclerosis review. PT 37:175\u2013184","journal-title":"PT"},{"key":"1011_CR86","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1177\/1352458507080111","volume":"14","author":"R Gonsette","year":"2008","unstructured":"Gonsette R (2008) Oxidative stress and excitotoxicity: a therapeutic issue in multiple sclerosis? Mult Scler 14:22\u201334. https:\/\/doi.org\/10.1177\/1352458507080111","journal-title":"Mult Scler"},{"key":"1011_CR87","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1159\/000058094","volume":"57","author":"MM Grumbach","year":"2002","unstructured":"Grumbach MM (2002) The neuroendocrinology of human puberty revisited. Horm Res Paediatr 57:2\u201314. https:\/\/doi.org\/10.1159\/000058094","journal-title":"Horm Res Paediatr"},{"key":"1011_CR88","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1016\/j.neurol.2019.07.025","volume":"176","author":"M Gunata","year":"2020","unstructured":"Gunata M, Parlakpinar H, Acet HA (2020) Melatonin: a review of its potential functions and effects on neurological diseases. Rev Neurol (paris) 176:148\u2013165. https:\/\/doi.org\/10.1016\/j.neurol.2019.07.025","journal-title":"Rev Neurol (paris)"},{"key":"1011_CR89","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/725370","author":"L Haider","year":"2015","unstructured":"Haider L (2015) Inflammation, iron, energy failure, and oxidative stress in the pathogenesis of multiple sclerosis. Oxid Med Cell Longev. https:\/\/doi.org\/10.1155\/2015\/725370","journal-title":"Oxid Med Cell Longev"},{"key":"1011_CR90","doi-asserted-by":"publisher","DOI":"10.1177\/1756285613488434","author":"HF Harbo","year":"2013","unstructured":"Harbo HF, Gold R, Tintora M (2013) Sex and gender issues in multiple sclerosis. Ther Adv Neurol Disord. https:\/\/doi.org\/10.1177\/1756285613488434","journal-title":"Ther Adv Neurol Disord"},{"key":"1011_CR91","first-page":"141","volume":"28","author":"A Hassanpour-Dehkordi","year":"2014","unstructured":"Hassanpour-Dehkordi A, Jivad N (2014) Comparison of regular aerobic and yoga on the quality of life in patients with multiple sclerosis. Med J Islam Repub Iran 28:141","journal-title":"Med J Islam Repub Iran"},{"key":"1011_CR92","first-page":"2611","volume-title":"Harrison\u2019s principles of internal medicine","author":"S Hauser","year":"2008","unstructured":"Hauser S, Goodwin D (2008) Multiple sclerosis and other demyelinating diseases. Harrison\u2019s principles of internal medicine, 17th edn. McGraw-Hill Medical, New York, pp 2611\u20132621","edition":"17"},{"key":"1011_CR93","doi-asserted-by":"publisher","DOI":"10.1084\/jem.170.2.607","author":"FM Hofman","year":"1989","unstructured":"Hofman FM, Hinton DR, Johnson K, Merrill JE (1989) Tumor necrosis factor identified in multiple sclerosis brain. J Exp Med. https:\/\/doi.org\/10.1084\/jem.170.2.607","journal-title":"J Exp Med"},{"key":"1011_CR94","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/61.3.638S","author":"MF Holick","year":"1995","unstructured":"Holick MF (1995) Environmental factors that influence the cutaneous production of vitamin D. Am J Clin Nutr. https:\/\/doi.org\/10.1093\/ajcn\/61.3.638S","journal-title":"Am J Clin Nutr"},{"key":"1011_CR95","doi-asserted-by":"publisher","first-page":"1012","DOI":"10.1177\/1352458519893925","volume":"26","author":"KF Holton","year":"2020","unstructured":"Holton KF, Kirkland AE (2020) Moving past antioxidant supplementation for the dietary treatment of multiple sclerosis. Mult Scler J 26:1012\u20131023. https:\/\/doi.org\/10.1177\/1352458519893925","journal-title":"Mult Scler J"},{"key":"1011_CR96","doi-asserted-by":"publisher","first-page":"2509","DOI":"10.1210\/JCEM.85.7.6689","volume":"85","author":"MB HorlickK","year":"2000","unstructured":"HorlickK MB, Rosenbaum M, Nicholson M et al (2000) Effect of puberty on the relationship between circulating leptin and body composition. J Clin Endocrinol Metab 85:2509\u20132518. https:\/\/doi.org\/10.1210\/JCEM.85.7.6689","journal-title":"J Clin Endocrinol Metab"},{"key":"1011_CR97","doi-asserted-by":"publisher","first-page":"3163","DOI":"10.3892\/etm.2017.4410","volume":"13","author":"WJ Huang","year":"2017","unstructured":"Huang WJ, Chen WW, Zhang X (2017) Multiple sclerosis: pathology, diagnosis and treatments (review). Exp Ther Med 13:3163\u20133166. https:\/\/doi.org\/10.3892\/etm.2017.4410","journal-title":"Exp Ther Med"},{"key":"1011_CR98","doi-asserted-by":"publisher","DOI":"10.1016\/j.jff.2019.04.062","author":"SH Huang","year":"2019","unstructured":"Huang SH, Liao CL, Chen SJ et al (2019) Melatonin possesses an anti-influenza potential through its immune modulatory effect. J Funct Foods. https:\/\/doi.org\/10.1016\/j.jff.2019.04.062","journal-title":"J Funct Foods"},{"key":"1011_CR99","doi-asserted-by":"publisher","DOI":"10.1016\/j.smrv.2020.101379","author":"LM Huiberts","year":"2021","unstructured":"Huiberts LM, Smolders KCHJ (2021) Effects of vitamin D on mood and sleep in the healthy population: interpretations from the serotonergic pathway. Sleep Med Rev. https:\/\/doi.org\/10.1016\/j.smrv.2020.101379","journal-title":"Sleep Med Rev"},{"key":"1011_CR100","doi-asserted-by":"publisher","DOI":"10.1371\/JOURNAL.PPAT.1008811","author":"A Iannucci","year":"2020","unstructured":"Iannucci A, Caneparo V, Raviola S et al (2020) Toll-like receptor 4-mediated inflammation triggered by extracellular IFI16 is enhanced by lipopolysaccharide binding. PLoS Pathog. https:\/\/doi.org\/10.1371\/JOURNAL.PPAT.1008811","journal-title":"PLoS Pathog"},{"key":"1011_CR101","doi-asserted-by":"publisher","DOI":"10.1016\/j.chest.2020.05.580","author":"L Jehi","year":"2020","unstructured":"Jehi L, Ji X, Milinovich A et al (2020) Individualizing risk prediction for positive coronavirus disease 2019 testing: results from 11,672 patients. Chest. https:\/\/doi.org\/10.1016\/j.chest.2020.05.580","journal-title":"Chest"},{"key":"1011_CR102","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1016\/S0022-510X(00)00408-1","volume":"181","author":"YP Jin","year":"2000","unstructured":"Jin YP, De Pedro-Cuesta J, S\u00f6derstr\u00f6m M et al (2000) Seasonal patterns in optic neuritis and multiple sclerosis: a meta-analysis. J Neurol Sci 181:56\u201364. https:\/\/doi.org\/10.1016\/S0022-510X(00)00408-1","journal-title":"J Neurol Sci"},{"key":"1011_CR103","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kfp274","author":"DA Johnson","year":"2009","unstructured":"Johnson DA, Amirahmadi S, Ward C et al (2009) The absence of the pro-antioxidant transcription factor Nrf2 exacerbates experimental autoimmune encephalomyelitis. Toxicol Sci. https:\/\/doi.org\/10.1093\/toxsci\/kfp274","journal-title":"Toxicol Sci"},{"key":"1011_CR104","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2020.101211","author":"H Kahroba","year":"2021","unstructured":"Kahroba H, Ramezani B, Maadi H et al (2021) The role of Nrf2 in neural stem\/progenitors cells: from maintaining stemness and self-renewal to promoting differentiation capability and facilitating therapeutic application in neurodegenerative disease. Ageing Res Rev. https:\/\/doi.org\/10.1016\/j.arr.2020.101211","journal-title":"Ageing Res Rev"},{"key":"1011_CR105","doi-asserted-by":"publisher","DOI":"10.1002\/cbf.1055","author":"A Kamanli","year":"2004","unstructured":"Kamanli A, Naziro\u01e7lu M, Aydilek N, Hacievliyagil C (2004) Plasma lipid peroxidation and antioxidant levels in patients with rheumatoid arthritis. Cell Biochem Funct. https:\/\/doi.org\/10.1002\/cbf.1055","journal-title":"Cell Biochem Funct"},{"key":"1011_CR106","doi-asserted-by":"publisher","DOI":"10.4142\/jvs.2001.2.2.85","author":"JC Kang","year":"2001","unstructured":"Kang JC, Ahn M, Kim YS et al (2001) Melatonin ameliorates autoimmune encephalomyelitis through suppression of intercellular adhesion molecule-1. J Vet Sci (Suwon-si, Korea). https:\/\/doi.org\/10.4142\/jvs.2001.2.2.85","journal-title":"J Vet Sci (Suwon-si, Korea)"},{"key":"1011_CR107","doi-asserted-by":"publisher","DOI":"10.1016\/j.ensci.2020.100287","author":"S Kataria","year":"2020","unstructured":"Kataria S, Tandon M, Melnic V, Sriwastava S (2020) A case series and literature review of multiple sclerosis and COVID-19: clinical characteristics, outcomes and a brief review of immunotherapies. eNeurologicalSci. https:\/\/doi.org\/10.1016\/j.ensci.2020.100287","journal-title":"eNeurologicalSci"},{"key":"1011_CR108","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1016\/j.gene.2016.03.058","volume":"586","author":"F Katsuoka","year":"2016","unstructured":"Katsuoka F, Yamamoto M (2016) Small maf proteins (MafF, MafG, MafK): history, structure and function. Gene 586:197\u2013205. https:\/\/doi.org\/10.1016\/j.gene.2016.03.058","journal-title":"Gene"},{"key":"1011_CR109","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1038\/ni.1863","volume":"11","author":"T Kawai","year":"2010","unstructured":"Kawai T, Akira S (2010) The role of pattern-recognition receptors in innate immunity: update on toll-like receptors. Nat Immunol 11:373\u2013384. https:\/\/doi.org\/10.1038\/ni.1863","journal-title":"Nat Immunol"},{"key":"1011_CR110","doi-asserted-by":"publisher","DOI":"10.1038\/nm1651","author":"H Kebir","year":"2007","unstructured":"Kebir H, Kreymborg K, Ifergan I et al (2007) Human TH17 lymphocytes promote blood-brain barrier disruption and central nervous system inflammation. Nat Med. https:\/\/doi.org\/10.1038\/nm1651","journal-title":"Nat Med"},{"key":"1011_CR111","doi-asserted-by":"publisher","first-page":"1547","DOI":"10.1007\/s00109-019-01821-w","volume":"97","author":"S Kern","year":"2019","unstructured":"Kern S, Geiger M, Paucke M et al (2019) Clinical relevance of circadian melatonin release in relapsing-remitting multiple sclerosis. J Mol Med 97:1547\u20131555. https:\/\/doi.org\/10.1007\/s00109-019-01821-w","journal-title":"J Mol Med"},{"key":"1011_CR112","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-59314-7","author":"SW Kim","year":"2020","unstructured":"Kim SW, Kim S, Son M et al (2020) Melatonin controls microbiota in colitis by goblet cell differentiation and antimicrobial peptide production through Toll-like receptor 4 signalling. Sci Rep. https:\/\/doi.org\/10.1038\/s41598-020-59314-7","journal-title":"Sci Rep"},{"key":"1011_CR113","doi-asserted-by":"publisher","first-page":"765","DOI":"10.2165\/11534530-000000000-00000","volume":"40","author":"K Knaepen","year":"2010","unstructured":"Knaepen K, Goekint M, Heyman EM, Meeusen R (2010) Neuroplasticity exercise-induced response of peripheral brain-derived neurotrophic factor: a systematic review of experimental studies in human subjects. Sport Med 40:765\u2013801. https:\/\/doi.org\/10.2165\/11534530-000000000-00000","journal-title":"Sport Med"},{"key":"1011_CR114","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20080159","author":"MA Kroenke","year":"2008","unstructured":"Kroenke MA, Carlson TJ, Andjelkovic AV, Segal BM (2008) IL-12- and IL-23-modulated T cells induce distinct types of EAE based on histology, CNS chemokine profile, and response to cytokine inhibition. J Exp Med. https:\/\/doi.org\/10.1084\/jem.20080159","journal-title":"J Exp Med"},{"key":"1011_CR115","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41598-017-14520-8","volume":"7","author":"E Kubo","year":"2017","unstructured":"Kubo E, Chhunchha B, Singh P et al (2017) Sulforaphane reactivates cellular antioxidant defense by inducing Nrf2\/ARE\/Prdx6 activity during aging and oxidative stress. Sci Rep 7:1\u201317. https:\/\/doi.org\/10.1038\/s41598-017-14520-8","journal-title":"Sci Rep"},{"key":"1011_CR116","doi-asserted-by":"publisher","first-page":"771","DOI":"10.1016\/j.bbi.2020.11.004","volume":"91","author":"B Lahooti","year":"2021","unstructured":"Lahooti B, Chhibber T, Bagchi S et al (2021) Therapeutic role of inflammasome inhibitors in neurodegenerative disorders. Brain Behav Immun 91:771\u2013783. https:\/\/doi.org\/10.1016\/j.bbi.2020.11.004","journal-title":"Brain Behav Immun"},{"key":"1011_CR117","doi-asserted-by":"publisher","first-page":"432","DOI":"10.1002\/cbin.11500","volume":"45","author":"J Langhnoja","year":"2021","unstructured":"Langhnoja J, Buch L, Pillai P (2021) Potential role of NGF, BDNF, and their receptors in oligodendrocytes differentiation from neural stem cell: an in vitro study. Cell Biol Int 45:432\u2013446. https:\/\/doi.org\/10.1002\/cbin.11500","journal-title":"Cell Biol Int"},{"key":"1011_CR118","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2015.09.018","author":"H Lassmann","year":"2016","unstructured":"Lassmann H, van Horssen J (2016) Oxidative stress and its impact on neurons and glia in multiple sclerosis lesions. Biochim Biophys Acta - Mol Basis Dis. https:\/\/doi.org\/10.1016\/j.bbadis.2015.09.018","journal-title":"Biochim Biophys Acta - Mol Basis Dis"},{"key":"1011_CR119","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1111\/j.1750-3639.2007.00064.x","volume":"17","author":"H Lassmann","year":"2007","unstructured":"Lassmann H, Br\u00fcck W, Lucchinetti CF (2007) The immunopathology of multiple sclerosis: an overview. Brain Pathol 17:210\u2013218. https:\/\/doi.org\/10.1111\/j.1750-3639.2007.00064.x","journal-title":"Brain Pathol"},{"key":"1011_CR120","doi-asserted-by":"publisher","first-page":"647","DOI":"10.1038\/NRNEUROL.2012.168","volume":"8","author":"H Lassmann","year":"2012","unstructured":"Lassmann H, van Horssen J, Mahad D (2012) Progressive multiple sclerosis: pathology and pathogenesis. Nat Rev Neurol 8:647\u2013656. https:\/\/doi.org\/10.1038\/NRNEUROL.2012.168","journal-title":"Nat Rev Neurol"},{"key":"1011_CR121","doi-asserted-by":"publisher","first-page":"765","DOI":"10.1016\/J.LFS.2004.03.003","volume":"75","author":"J Leon","year":"2004","unstructured":"Leon J, Acu\u00f1a-Castroviejo D, Sainz R et al (2004) Melatonin and mitochondrial function. Life Sci 75:765\u2013790. https:\/\/doi.org\/10.1016\/J.LFS.2004.03.003","journal-title":"Life Sci"},{"key":"1011_CR122","doi-asserted-by":"publisher","first-page":"11208","DOI":"10.3390\/ijms140611208","volume":"14","author":"DY Li","year":"2013","unstructured":"Li DY, Smith DG, Hardel R et al (2013) Melatonin receptor genes in vertebrates. Int J Mol Sci 14:11208\u201311223. https:\/\/doi.org\/10.3390\/ijms140611208","journal-title":"Int J Mol Sci"},{"key":"1011_CR123","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1007\/s00401-015-1452-x","volume":"130","author":"S Licht-Mayer","year":"2015","unstructured":"Licht-Mayer S, Wimmer I, Traffehn S et al (2015) Cell type-specific Nrf2 expression in multiple sclerosis lesions. Acta Neuropathol 130:263\u2013277. https:\/\/doi.org\/10.1007\/s00401-015-1452-x","journal-title":"Acta Neuropathol"},{"key":"1011_CR124","doi-asserted-by":"publisher","first-page":"2513","DOI":"10.1093\/humrep\/dez215","volume":"34","author":"J Liebenthron","year":"2019","unstructured":"Liebenthron J, Reinsberg J, Van Der Ven K et al (2019) Serum anti-m\u00fcllerian hormone concentration and follicle density throughout reproductive life and in different diseases - implications in fertility preservation. Hum Reprod 34:2513\u20132522. https:\/\/doi.org\/10.1093\/humrep\/dez215","journal-title":"Hum Reprod"},{"key":"1011_CR125","doi-asserted-by":"publisher","first-page":"11742","DOI":"10.3390\/ijms140611742","volume":"14","author":"GJ Lin","year":"2013","unstructured":"Lin GJ, Huang SH, Chen SJ et al (2013) Modulation by melatonin of the pathogenesis of inflammatory autoimmune diseases. Int J Mol Sci 14:11742\u201311766. https:\/\/doi.org\/10.3390\/ijms140611742","journal-title":"Int J Mol Sci"},{"key":"1011_CR126","doi-asserted-by":"publisher","DOI":"10.1038\/nm0502-500","author":"C Lock","year":"2002","unstructured":"Lock C, Hermans G, Pedotti R et al (2002) Gene-microarray analysis of multiple sclerosis lesions yields new targets validated in autoimmune encephalomyelitis. Nat Med. https:\/\/doi.org\/10.1038\/nm0502-500","journal-title":"Nat Med"},{"key":"1011_CR127","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1096\/FSB2FASEBJ.12.1.57","volume":"12","author":"S Loffreda","year":"1998","unstructured":"Loffreda S, Yang SQ, Lin HZ et al (1998) Leptin regulates proinflammatory immune responses. FASEB J 12:57\u201365. https:\/\/doi.org\/10.1096\/FSB2FASEBJ.12.1.57","journal-title":"FASEB J"},{"key":"1011_CR128","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1007\/s12031-017-1022-x","volume":"64","author":"T Long","year":"2018","unstructured":"Long T, Yang Y, Peng L, Li Z (2018) Neuroprotective effects of melatonin on experimental allergic encephalomyelitis mice via anti-oxidative stress activity. J Mol Neurosci 64:233\u2013241. https:\/\/doi.org\/10.1007\/s12031-017-1022-x","journal-title":"J Mol Neurosci"},{"key":"1011_CR129","doi-asserted-by":"publisher","first-page":"209","DOI":"10.18632\/genesandcancer.107","volume":"7","author":"J Lopes","year":"2016","unstructured":"Lopes J, Arnosti D, Trosko JE et al (2016) Melatonin decreases estrogen receptor binding to estrogen response elements sites on the oct4 gene in human breast cancer stem cells. Genes and Cancer 7:209\u2013217. https:\/\/doi.org\/10.18632\/genesandcancer.107","journal-title":"Genes and Cancer"},{"key":"1011_CR130","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2019.3365","author":"G Luna","year":"2020","unstructured":"Luna G, Alping P, Burman J et al (2020) Infection risks among patients with multiple sclerosis treated with fingolimod, natalizumab, rituximab, and injectable therapies. JAMA Neurol. https:\/\/doi.org\/10.1001\/jamaneurol.2019.3365","journal-title":"JAMA Neurol"},{"key":"1011_CR131","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2019.117191","author":"J Luo","year":"2020","unstructured":"Luo J, Zhang Z, Sun H et al (2020) Effect of melatonin on T\/B cell activation and immune regulation in pinealectomy mice. Life Sci. https:\/\/doi.org\/10.1016\/j.lfs.2019.117191","journal-title":"Life Sci"},{"key":"1011_CR132","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1007\/S12035-018-1051-7\/TABLES\/5","volume":"56","author":"M Maes","year":"2019","unstructured":"Maes M, Landucci Bonifacio K, Morelli NR et al (2019) Major differences in neurooxidative and neuronitrosative stress pathways between major depressive disorder and types I and II bipolar disorder. Mol Neurobiol 56:141\u2013156. https:\/\/doi.org\/10.1007\/S12035-018-1051-7\/TABLES\/5","journal-title":"Mol Neurobiol"},{"key":"1011_CR133","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1016\/S1474-4422(14)70256-X","volume":"14","author":"DH Mahad","year":"2015","unstructured":"Mahad DH, Trapp BD, Lassmann H (2015) Pathological mechanisms in progressive multiple sclerosis. Lancet Neurol 14:183\u2013193. https:\/\/doi.org\/10.1016\/S1474-4422(14)70256-X","journal-title":"Lancet Neurol"},{"key":"1011_CR134","doi-asserted-by":"publisher","first-page":"282","DOI":"10.1016\/j.phrs.2009.11.014","volume":"62","author":"MD Maldonado","year":"2010","unstructured":"Maldonado MD, Mora-Santos M, Naji L et al (2010) Evidence of melatonin synthesis and release by mast cells. Possible modulatory role on inflammation. Pharmacol Res 62:282\u2013287. https:\/\/doi.org\/10.1016\/j.phrs.2009.11.014","journal-title":"Pharmacol Res"},{"key":"1011_CR135","doi-asserted-by":"publisher","first-page":"799","DOI":"10.3389\/fnins.2018.00799","volume":"12","author":"JM Marcus","year":"2018","unstructured":"Marcus JM, Andrabi SA (2018) SIRT3 Regulation under cellular stress: making sense of the ups and downs. Front Neurosci 12:799. https:\/\/doi.org\/10.3389\/fnins.2018.00799","journal-title":"Front Neurosci"},{"key":"1011_CR136","doi-asserted-by":"publisher","first-page":"1677","DOI":"10.1096\/FJ.99-0865FJE","volume":"14","author":"M Mart\u00edn","year":"2000","unstructured":"Mart\u00edn M, Mac\u00edas M, Escames G et al (2000a) Melatonin but not vitamins C and E maintains glutathione homeostasis in t-butyl hydroperoxide-induced mitochondrial oxidative stress. FASEB J 14:1677\u20131679. https:\/\/doi.org\/10.1096\/FJ.99-0865FJE","journal-title":"FASEB J"},{"key":"1011_CR137","doi-asserted-by":"publisher","first-page":"242","DOI":"10.1034\/J.1600-079X.2000.280407.X","volume":"28","author":"M Mart\u00edn","year":"2000","unstructured":"Mart\u00edn M, Mac\u00edas M, Escames G et al (2000b) Melatonin-induced increased activity of the respiratory chain complexes I and IV can prevent mitochondrial damage induced by ruthenium red in vivo. J Pineal Res 28:242\u2013248. https:\/\/doi.org\/10.1034\/J.1600-079X.2000.280407.X","journal-title":"J Pineal Res"},{"key":"1011_CR138","doi-asserted-by":"publisher","first-page":"348","DOI":"10.1016\/S1357-2725(01)00138-8","volume":"34","author":"M Mart\u00edn","year":"2002","unstructured":"Mart\u00edn M, Mac\u00edas M, Le\u00f3n J et al (2002) Melatonin increases the activity of the oxidative phosphorylation enzymes and the production of ATP in rat brain and liver mitochondria. Int J Biochem Cell Biol 34:348\u2013357. https:\/\/doi.org\/10.1016\/S1357-2725(01)00138-8","journal-title":"Int J Biochem Cell Biol"},{"key":"1011_CR139","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2020.117808","author":"VM Mart\u00edn Gim\u00e9nez","year":"2020","unstructured":"Mart\u00edn Gim\u00e9nez VM, Inserra F, Tajer CD et al (2020) Lungs as target of COVID-19 infection: protective common molecular mechanisms of vitamin D and melatonin as a new potential synergistic treatment. Life Sci. https:\/\/doi.org\/10.1016\/j.lfs.2020.117808","journal-title":"Life Sci"},{"key":"1011_CR140","doi-asserted-by":"publisher","first-page":"1220","DOI":"10.4103\/1673-5374.272572","volume":"15","author":"B Martinez","year":"2020","unstructured":"Martinez B, Peplow PV (2020) Protective effects of pharmacological therapies in animal models of multiple sclerosis: a review of studies 2014\u20132019. Neural Regen Res 15:1220\u20131234. https:\/\/doi.org\/10.4103\/1673-5374.272572","journal-title":"Neural Regen Res"},{"key":"1011_CR141","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1016\/j.nrl.2020.03.001","volume":"35","author":"J Mat\u00edas-Guiu","year":"2020","unstructured":"Mat\u00edas-Guiu J, Gomez-Pinedo U, Montero-Escribano P et al (2020) Should we expect neurological symptoms in the SARS-CoV-2 epidemic? Neurologia 35:170\u2013175. https:\/\/doi.org\/10.1016\/j.nrl.2020.03.001","journal-title":"Neurologia"},{"key":"1011_CR142","doi-asserted-by":"publisher","first-page":"507","DOI":"10.1515\/revneuro-2013-0024","volume":"24","author":"FJ Medina","year":"2013","unstructured":"Medina FJ, T\u00fanez I (2013) Mechanisms and pathways underlying the therapeutic effect of transcranial magnetic stimulation. Rev Neurosci 24:507\u2013525. https:\/\/doi.org\/10.1515\/revneuro-2013-0024","journal-title":"Rev Neurosci"},{"key":"1011_CR143","doi-asserted-by":"publisher","first-page":"460","DOI":"10.1080\/10715762.2017.1324955","volume":"51","author":"F Medina-Fernandez","year":"2017","unstructured":"Medina-Fernandez F, Escribano B, Ag\u00fcera E et al (2017) Effects of transcranial magnetic stimulation on oxidative stress in experimental autoimmune encephalomyelitis. Free Radic Res 51:460\u2013469. https:\/\/doi.org\/10.1080\/10715762.2017.1324955","journal-title":"Free Radic Res"},{"key":"1011_CR144","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1016\/J.BRAINRESBULL.2017.11.018","volume":"137","author":"F Medina-Fernandez","year":"2018","unstructured":"Medina-Fernandez F, Escribano B, Luque E et al (2018) Comparative of transcranial magnetic stimulation and other treatments in experimental autoimmune encephalomyelitis. Brain Res Bull 137:140\u2013145. https:\/\/doi.org\/10.1016\/J.BRAINRESBULL.2017.11.018","journal-title":"Brain Res Bull"},{"key":"1011_CR145","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2016.11.011","author":"FJ Medina-Fern\u00e1ndez","year":"2017","unstructured":"Medina-Fern\u00e1ndez FJ, Luque E, Aguilar-Luque M et al (2017) Transcranial magnetic stimulation modifies astrocytosis, cell density and lipopolysaccharide levels in experimental autoimmune encephalomyelitis. Life Sci. https:\/\/doi.org\/10.1016\/j.lfs.2016.11.011","journal-title":"Life Sci"},{"key":"1011_CR146","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1080\/10715762.2018.1434313","volume":"52","author":"F Medina-Fern\u00e1ndez","year":"2018","unstructured":"Medina-Fern\u00e1ndez F, Escribano B, Padilla-Del-Campo C et al (2018) Transcranial magnetic stimulation as an antioxidant. Free Radic Res 52:381\u2013389. https:\/\/doi.org\/10.1080\/10715762.2018.1434313","journal-title":"Free Radic Res"},{"key":"1011_CR248","unstructured":"Melatonin in Patients With Multiple Sclerosis (MS). - Full Text View - ClinicalTrials.gov. https:\/\/clinicaltrials.gov\/ct2\/show\/NCT3498131\/. Accessed 3 Sep 2021"},{"key":"1011_CR147","doi-asserted-by":"publisher","first-page":"781","DOI":"10.1007\/s00702-017-1732-9","volume":"125","author":"AS Mendiola","year":"2018","unstructured":"Mendiola AS, Cardona AE (2018) The IL-1\u03b2 phenomena in neuroinflammatory diseases. J Neural Transm 125:781\u2013795. https:\/\/doi.org\/10.1007\/s00702-017-1732-9","journal-title":"J Neural Transm"},{"key":"1011_CR148","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1038\/s41577-020-0331-4","volume":"20","author":"M Merad","year":"2020","unstructured":"Merad M, Martin JC (2020) Pathological inflammation in patients with COVID-19: a key role for monocytes and macrophages. Nat Rev Immunol 20:355\u2013362. https:\/\/doi.org\/10.1038\/s41577-020-0331-4","journal-title":"Nat Rev Immunol"},{"key":"1011_CR149","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2020.172973","author":"D Michali\u010dkov\u00e1","year":"2020","unstructured":"Michali\u010dkov\u00e1 D, Hrn\u010d\u00ed\u0159 T, Canov\u00e1 NK, Slana\u0159 O (2020a) Targeting Keap1\/Nrf2\/ARE signaling pathway in multiple sclerosis. Eur J Pharmacol. https:\/\/doi.org\/10.1016\/j.ejphar.2020.172973","journal-title":"Eur J Pharmacol"},{"key":"1011_CR150","doi-asserted-by":"publisher","first-page":"1","DOI":"10.33549\/physiolres.934276","volume":"69","author":"D Michali\u010dkov\u00e1","year":"2020","unstructured":"Michali\u010dkov\u00e1 D, \u0160\u00edma M, Slana\u0159 O (2020) New insights in the mechanisms of impaired redox signaling and its interplay with inflammation and immunity in multiple sclerosis. Physiol Res 69:1\u201319. https:\/\/doi.org\/10.33549\/physiolres.934276","journal-title":"Physiol Res"},{"key":"1011_CR151","doi-asserted-by":"publisher","first-page":"223","DOI":"10.3109\/15622975.2010.518626","volume":"12","author":"E Miller","year":"2011","unstructured":"Miller E, Mrowicka M, Malinowska K et al (2011) Effects of whole-body cryotherapy on a total antioxidative status and activities of antioxidative enzymes in blood of depressive multiple sclerosis patients. World J Biol Psychiatry 12:223\u2013227. https:\/\/doi.org\/10.3109\/15622975.2010.518626","journal-title":"World J Biol Psychiatry"},{"key":"1011_CR152","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1016\/J.JNEUROIM.2013.02.012","volume":"257","author":"E Miller","year":"2013","unstructured":"Miller E, Walczak A, Majsterek I, K\u0119dziora J (2013) Melatonin reduces oxidative stress in the erythrocytes of multiple sclerosis patients with secondary progressive clinical course. J Neuroimmunol 257:97\u2013101. https:\/\/doi.org\/10.1016\/J.JNEUROIM.2013.02.012","journal-title":"J Neuroimmunol"},{"key":"1011_CR153","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0137429","author":"S Miyake","year":"2015","unstructured":"Miyake S, Kim S, Suda W et al (2015) Dysbiosis in the gut microbiota of patients with multiple sclerosis, with a striking depletion of species belonging to clostridia XIVa and IV clusters. PLoS ONE. https:\/\/doi.org\/10.1371\/journal.pone.0137429","journal-title":"PLoS ONE"},{"key":"1011_CR154","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsbmb.2020.105595","author":"FJ Mocayar-Mar\u00f3n","year":"2020","unstructured":"Mocayar-Mar\u00f3n FJ, Ferder L, Reiter RJ, Manucha W (2020) Daily and seasonal mitochondrial protection: unraveling common possible mechanisms involving vitamin D and melatonin. J Steroid Biochem Mol Biol. https:\/\/doi.org\/10.1016\/j.jsbmb.2020.105595","journal-title":"J Steroid Biochem Mol Biol"},{"key":"1011_CR155","doi-asserted-by":"publisher","first-page":"2158","DOI":"10.1007\/s12035-020-02212-w","volume":"58","author":"G Morris","year":"2021","unstructured":"Morris G, Walker AJ, Walder K et al (2021) Increasing Nrf2 activity as a treatment approach in neuropsychiatry. Mol Neurobiol 58:2158\u20132182. https:\/\/doi.org\/10.1007\/s12035-020-02212-w","journal-title":"Mol Neurobiol"},{"key":"1011_CR156","doi-asserted-by":"publisher","DOI":"10.1002\/hipo.1105","author":"U Musshoff","year":"2002","unstructured":"Musshoff U, Riewenherm D, Berger E et al (2002) Melatonin receptors in rat hippocampus: molecular and functional investigations. Hippocampus. https:\/\/doi.org\/10.1002\/hipo.1105","journal-title":"Hippocampus"},{"key":"1011_CR157","doi-asserted-by":"publisher","first-page":"2251","DOI":"10.1002\/acn3.51215","volume":"7","author":"Y Naegelin","year":"2020","unstructured":"Naegelin Y, Saeuberli K, Schaedelin S et al (2020) Levels of brain-derived neurotrophic factor in patients with multiple sclerosis. Ann Clin Transl Neurol 7:2251\u20132261. https:\/\/doi.org\/10.1002\/acn3.51215","journal-title":"Ann Clin Transl Neurol"},{"key":"1011_CR158","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0170028","author":"HC Nien","year":"2017","unstructured":"Nien HC, Hsu SJ, Su TH et al (2017) High serum lipopolysaccharide-binding protein level in chronic hepatitis C viral infection is reduced by anti-viral treatments. PLoS ONE. https:\/\/doi.org\/10.1371\/journal.pone.0170028","journal-title":"PLoS ONE"},{"key":"1011_CR159","doi-asserted-by":"publisher","DOI":"10.1186\/1471.2202-5-41","author":"LP Niles","year":"2004","unstructured":"Niles LP, Armstrong KJ, Rinc\u00f3n Castro LM et al (2004) Neural stem cells express melatonin receptors and neurotrophic factors: colocalization of the MT1 receptor with neuronal and glial markers. BMC Neurosci. https:\/\/doi.org\/10.1186\/1471.2202-5-41","journal-title":"BMC Neurosci"},{"key":"1011_CR160","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2020.108380","author":"D Noto","year":"2020","unstructured":"Noto D, Miyake S (2020) Gut dysbiosis and multiple sclerosis. Clin Immunol. https:\/\/doi.org\/10.1016\/j.clim.2020.108380","journal-title":"Clin Immunol"},{"key":"1011_CR161","doi-asserted-by":"publisher","DOI":"10.1002\/ana.22344","author":"J Ochoa-Rep\u00e1raz","year":"2011","unstructured":"Ochoa-Rep\u00e1raz J, Mielcarz DW, Begum- Haque S, Kasper LH (2011) Gut, bugs, and brain: role of commensal bacteria in the control of central nervous system disease. Ann Neurol. https:\/\/doi.org\/10.1002\/ana.22344","journal-title":"Ann Neurol"},{"key":"1011_CR162","doi-asserted-by":"publisher","first-page":"945","DOI":"10.1016\/j.pharep.2016.04.003","volume":"68","author":"EA Og\u0142odek","year":"2016","unstructured":"Og\u0142odek EA, Just MJ, Szromek AR, Araszkiewicz A (2016) Melatonin and neurotrophins NT-3, BDNF, NGF in patients with varying levels of depression severity. Pharmacol Reports 68:945\u2013951. https:\/\/doi.org\/10.1016\/j.pharep.2016.04.003","journal-title":"Pharmacol Reports"},{"key":"1011_CR163","doi-asserted-by":"publisher","first-page":"563","DOI":"10.2174\/1570159x18666191230114339","volume":"18","author":"OJ Onaolapo","year":"2019","unstructured":"Onaolapo OJ, Onaolapo AY, Olowe OA et al (2019) Melatonin and melatonergic influence on neuronal transcription factors: implications for the development of novel therapies for neurodegenerative disorders. Curr Neuropharmacol 18:563\u2013577. https:\/\/doi.org\/10.2174\/1570159x18666191230114339","journal-title":"Curr Neuropharmacol"},{"key":"1011_CR164","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1146\/annurev-med-042910-135833","volume":"63","author":"D Ontaneda","year":"2012","unstructured":"Ontaneda D, Hyland M, Cohen JA (2012) Multiple sclerosis: new insights in pathogenesis and novel therapeutics. Annu Rev Med 63:389\u2013404. https:\/\/doi.org\/10.1146\/annurev-med-042910-135833","journal-title":"Annu Rev Med"},{"key":"1011_CR165","doi-asserted-by":"publisher","DOI":"10.1186\/s41983-021-00296-2","author":"MI Oraby","year":"2021","unstructured":"Oraby MI, El Masry HA, Abd El Shafy SS, Abdul Galil EM (2021) Serum level of brain-derived neurotrophic factor in patients with relapsing\u2013remitting multiple sclerosis: a potential biomarker for disease activity. Egypt J Neurol Psychiatry Neurosurg. https:\/\/doi.org\/10.1186\/s41983-021-00296-2","journal-title":"Egypt J Neurol Psychiatry Neurosurg"},{"key":"1011_CR166","doi-asserted-by":"publisher","first-page":"1815","DOI":"10.3390\/JCM8111815","volume":"8","author":"R Padureanu","year":"2019","unstructured":"Padureanu R, Albu CV, Mititelu RR et al (2019) Oxidative stress and inflammation interdependence in multiple sclerosis. J Clin Med 8:1815. https:\/\/doi.org\/10.3390\/JCM8111815","journal-title":"J Clin Med"},{"key":"1011_CR167","doi-asserted-by":"publisher","DOI":"10.1016\/j.msard.2020.102377","author":"M Palao","year":"2020","unstructured":"Palao M, Fern\u00e1ndez-D\u00edaz E, Gracia-Gil J et al (2020) Multiple sclerosis following SARS-CoV-2 infection. Mult Scler Relat Disord. https:\/\/doi.org\/10.1016\/j.msard.2020.102377","journal-title":"Mult Scler Relat Disord"},{"key":"1011_CR168","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0231379","author":"ACS Palmer","year":"2020","unstructured":"Palmer ACS, Zortea M, Souza A et al (2020) Clinical impact of melatonin on breast cancer patients undergoing chemotherapy; effects on cognition, sleep and depressive symptoms: a randomized, double-blind, placebo-controlled trial. PLoS ONE. https:\/\/doi.org\/10.1371\/journal.pone.0231379","journal-title":"PLoS ONE"},{"key":"1011_CR169","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2009.01.009","author":"A Pandit","year":"2009","unstructured":"Pandit A, Vadnal J, Houston S et al (2009) Impaired regulation of electron transport chain subunit genes by nuclear respiratory factor 2 in multiple sclerosis. J Neurol Sci. https:\/\/doi.org\/10.1016\/j.jns.2009.01.009","journal-title":"J Neurol Sci"},{"key":"1011_CR170","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1111\/j.1600-079X.2010.00759.x","volume":"48","author":"G Paradies","year":"2010","unstructured":"Paradies G, Petrosillo G, Paradies V et al (2010) Melatonin, cardiolipin and mitochondrial bioenergetics in health and disease. J Pineal Res 48:297\u2013310. https:\/\/doi.org\/10.1111\/j.1600-079X.2010.00759.x","journal-title":"J Pineal Res"},{"key":"1011_CR171","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3390\/ANTIOX9100978","volume":"9","author":"JS Park","year":"2020","unstructured":"Park JS, Piao J, Park G, Hong HS (2020) Substance-P restores cellular activity of adsc impaired by oxidative stress. Antioxidants 9:1\u201310. https:\/\/doi.org\/10.3390\/ANTIOX9100978","journal-title":"Antioxidants"},{"key":"1011_CR172","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1003926","author":"NA Patsopoulos","year":"2013","unstructured":"Patsopoulos NA, Barcellos LF, Hintzen RQ et al (2013) Fine-mapping the genetic association of the major histocompatibility complex in multiple sclerosis: HLA and Non-HLA effects. PLoS Genet. https:\/\/doi.org\/10.1371\/journal.pgen.1003926","journal-title":"PLoS Genet"},{"key":"1011_CR173","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/7191080","author":"V Pegoretti","year":"2020","unstructured":"Pegoretti V, Swanson KA, Bethea JR et al (2020) Inflammation and oxidative stress in multiple sclerosis: consequences for therapy development. Oxid Med Cell Longev. https:\/\/doi.org\/10.1155\/2020\/7191080","journal-title":"Oxid Med Cell Longev"},{"key":"1011_CR174","doi-asserted-by":"publisher","DOI":"10.1212\/NXI.0000000000000120","author":"C Pozzilli","year":"2015","unstructured":"Pozzilli C, De Giglio L, Barletta VT et al (2015) Oral contraceptives combined with interferon b in multiple sclerosis. Neurol Neuroimmunol NeuroInflammation. https:\/\/doi.org\/10.1212\/NXI.0000000000000120","journal-title":"Neurol Neuroimmunol NeuroInflammation"},{"key":"1011_CR175","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1111\/j.1600-079X.2010.00824.x","volume":"50","author":"S Proietti","year":"2011","unstructured":"Proietti S, Cucina A, D\u2019Anselmi F et al (2011) Melatonin and vitamin D 3 synergistically down-regulate Akt and MDM2 leading to TGF\u03b2-1-dependent growth inhibition of breast cancer cells. J Pineal Res 50:150\u2013158. https:\/\/doi.org\/10.1111\/j.1600-079X.2010.00824.x","journal-title":"J Pineal Res"},{"key":"1011_CR176","doi-asserted-by":"publisher","first-page":"881","DOI":"10.1002\/ana.22678","volume":"70","author":"SV Ramagopalan","year":"2011","unstructured":"Ramagopalan SV, Dyment DA, Cader MZ et al (2011) Rare variants in the CYP27B1 gene are associated with multiple sclerosis. Ann Neurol 70:881\u2013886. https:\/\/doi.org\/10.1002\/ana.22678","journal-title":"Ann Neurol"},{"key":"1011_CR177","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/709493","author":"V Ramirez-Ramirez","year":"2013","unstructured":"Ramirez-Ramirez V, Macias-Islas MA, Ortiz GG et al (2013) Efficacy of fish oil on serum of TNF \u03b1, IL-1 \u03b2, and IL-6 oxidative stress markers in multiple sclerosis treated with interferon beta-1b. Oxid Med Cell Longev. https:\/\/doi.org\/10.1155\/2013\/709493","journal-title":"Oxid Med Cell Longev"},{"key":"1011_CR178","doi-asserted-by":"publisher","DOI":"10.1016\/j.nrl.2018.01.007","author":"EJ Ramos Gonz\u00e1lez","year":"2018","unstructured":"Ramos Gonz\u00e1lez EJ, Ramirez Jirano LJ, Garc\u00eda Mart\u00ednez DZ et al (2018) Estudio comparativo de melatonina contra los tratamientos inmunomoduladores (interfer\u00f3n beta y acetato de glatir\u00e1mero) en un modelo murino de esclerosis m\u00faltiple. Neurologia. https:\/\/doi.org\/10.1016\/j.nrl.2018.01.007","journal-title":"Neurologia"},{"key":"1011_CR179","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1779\/excli2016-763","volume":"16","author":"EE Rateb","year":"2017","unstructured":"Rateb EE, Amin SN, El-Tablawy N et al (2017) Effect of melatonin supplemented at the light or dark period on recovery of sciatic nerve injury in rats. EXCLI J 16:138\u2013150. https:\/\/doi.org\/10.1779\/excli2016-763","journal-title":"EXCLI J"},{"key":"1011_CR180","doi-asserted-by":"publisher","first-page":"376","DOI":"10.1111\/J.1749-6632.2000.TB05402.X","volume":"917","author":"R Reiter","year":"2000","unstructured":"Reiter R, Calvo J, Karbownik M et al (2000) Melatonin and its relation to the immune system and inflammation. Ann N Y Acad Sci 917:376\u2013386. https:\/\/doi.org\/10.1111\/J.1749-6632.2000.TB05402.X","journal-title":"Ann N Y Acad Sci"},{"key":"1011_CR181","doi-asserted-by":"publisher","DOI":"10.3390\/ijms19082439","author":"RJ Reiter","year":"2018","unstructured":"Reiter RJ, Tan DX, Rosales-Corral S et al (2018) Melatonin mitigates mitochondrial meltdown: Interactions with SIRT3. Int J Mol Sci. https:\/\/doi.org\/10.3390\/ijms19082439","journal-title":"Int J Mol Sci"},{"key":"1011_CR182","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0122686","author":"KA Ribbons","year":"2015","unstructured":"Ribbons KA, McElduff P, Boz C et al (2015) Male sex is independently associated with faster disability accumulation in relapse-onset MS but not in primary progressive MS. PLoS ONE. https:\/\/doi.org\/10.1371\/journal.pone.0122686","journal-title":"PLoS ONE"},{"key":"1011_CR183","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1007\/s10571-020-00938-8","volume":"42","author":"A Romero","year":"2020","unstructured":"Romero A, Ramos E, L\u00f3pez-Mu\u00f1oz F et al (2020) Coronavirus disease 2019 (COVID-19) and Its neuroinvasive capacity: is it time for melatonin? Cell Mol Neurobiol 42:489\u2013500. https:\/\/doi.org\/10.1007\/s10571-020-00938-8","journal-title":"Cell Mol Neurobiol"},{"issue":"6","key":"1011_CR184","first-page":"589","volume":"14","author":"T Roostaei","year":"2015","unstructured":"Roostaei T, Sahraian MA, Hajeaghaee S et al (2015) Impact of melatonin on motor, cognitive and neuroimaging indices in patients with multiple sclerosis. Iran J Allergy, Asthma Immunol 14(6):589\u201395","journal-title":"Iran J Allergy, Asthma Immunol"},{"key":"1011_CR185","doi-asserted-by":"publisher","DOI":"10.1038\/S41467-021-27427-W","author":"T Roostaei","year":"2021","unstructured":"Roostaei T, Klein H-U, Ma Y et al (2021) Proximal and distal effects of genetic susceptibility to multiple sclerosis on the T cell epigenome. Nat Commun. https:\/\/doi.org\/10.1038\/S41467-021-27427-W","journal-title":"Nat Commun"},{"key":"1011_CR186","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1111\/J.1600-079X.2011.00937.X","volume":"52","author":"S Rosales-Corral","year":"2012","unstructured":"Rosales-Corral S, Acu\u00f1a-Castroviejo D, Coto-Montes A et al (2012) Alzheimer\u2019s disease: pathological mechanisms and the beneficial role of melatonin. J Pineal Res 52:167\u2013202. https:\/\/doi.org\/10.1111\/J.1600-079X.2011.00937.X","journal-title":"J Pineal Res"},{"key":"1011_CR187","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1016\/j.immuni.2016.11.007","volume":"46","author":"JK Ryu","year":"2017","unstructured":"Ryu JK, Kim SJ, Rah SH et al (2017) Reconstruction of LPS transfer cascade reveals structural determinants within LBP, CD14, and TLR4-MD2 for efficient LPS recognition and transfer. Immunity 46:38\u201350. https:\/\/doi.org\/10.1016\/j.immuni.2016.11.007","journal-title":"Immunity"},{"key":"1011_CR188","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1007\/s11940-019-0544-7","volume":"21","author":"GK Sakkas","year":"2019","unstructured":"Sakkas GK, Giannaki CD, Karatzaferi C, Manconi M (2019) Sleep abnormalities in multiple sclerosis. Curr Treat Options Neurol 21:4. https:\/\/doi.org\/10.1007\/s11940-019-0544-7","journal-title":"Curr Treat Options Neurol"},{"key":"1011_CR189","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1016\/j.arcmed.2018.12.004","volume":"49","author":"AL S\u00e1nchez-L\u00f3pez","year":"2018","unstructured":"S\u00e1nchez-L\u00f3pez AL, Ortiz GG, Pacheco-Moises FP et al (2018) Efficacy of melatonin on serum pro-inflammatory cytokines and oxidative stress markers in relapsing remitting multiple sclerosis. Arch Med Res 49:391\u2013398. https:\/\/doi.org\/10.1016\/j.arcmed.2018.12.004","journal-title":"Arch Med Res"},{"key":"1011_CR190","doi-asserted-by":"publisher","first-page":"300","DOI":"10.1016\/0304-4165(90)90092-B","volume":"1035","author":"G Sandri","year":"1990","unstructured":"Sandri G, Panfili E, Ernster L (1990) Hydrogen peroxide production by monoamine oxidase in isolated rat-brain mitochondria: its effect on glutathione levels and Ca2+ efflux. Biochim Biophys Acta 1035:300\u2013305. https:\/\/doi.org\/10.1016\/0304-4165(90)90092-B","journal-title":"Biochim Biophys Acta"},{"key":"1011_CR191","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1177\/1352458506070146","volume":"13","author":"P Sarchielli","year":"2007","unstructured":"Sarchielli P, Zaffaroni M, Floridi A et al (2007) Production of brain-derived neurotrophic factor by mononuclear cells of patients with multiple sclerosis treated with glatiramer acetate, interferon-\u03b2 1a, and high doses of immunoglobulins. Mult Scler 13:313\u2013331. https:\/\/doi.org\/10.1177\/1352458506070146","journal-title":"Mult Scler"},{"key":"1011_CR192","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1016\/J.EXGER.2007.10.017","volume":"43","author":"V Senthil Kumaran","year":"2008","unstructured":"Senthil Kumaran V, Arulmathi K, Srividhya R, Kalaiselvi P (2008) Repletion of antioxidant status by EGCG and retardation of oxidative damage induced macromolecular anomalies in aged rats. Exp Gerontol 43:176\u2013183. https:\/\/doi.org\/10.1016\/J.EXGER.2007.10.017","journal-title":"Exp Gerontol"},{"key":"1011_CR193","doi-asserted-by":"publisher","first-page":"564","DOI":"10.1177\/1352458515602339","volume":"22","author":"M Sep\u00falveda","year":"2016","unstructured":"Sep\u00falveda M, Ros C, Mart\u00ednez-Lapiscina EH et al (2016) Pituitary-ovary axis and ovarian reserve in fertile women with multiple sclerosis: a pilot study. Mult Scler 22:564\u2013568. https:\/\/doi.org\/10.1177\/1352458515602339","journal-title":"Mult Scler"},{"key":"1011_CR194","doi-asserted-by":"publisher","first-page":"374","DOI":"10.3109\/0886022X.2012.760409","volume":"35","author":"G Sezgin","year":"2013","unstructured":"Sezgin G, \u00d6zt\u00fcrk G, G\u00fcney \u015e et al (2013) Protective effect of melatonin and 1,25-dihydroxyvitamin d3 on renal ischemia-reperfusion injury in rats. Ren Fail 35:374\u2013379. https:\/\/doi.org\/10.3109\/0886022X.2012.760409","journal-title":"Ren Fail"},{"key":"1011_CR195","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1111\/cns.12588","volume":"23","author":"SA Shah","year":"2017","unstructured":"Shah SA, Khan M, Jo MH et al (2017) Melatonin stimulates the SIRT1\/Nrf2 signaling pathway counteracting lipopolysaccharide (LPS)-induced oxidative stress to rescue postnatal rat brain. CNS Neurosci Ther 23:33\u201344. https:\/\/doi.org\/10.1111\/cns.12588","journal-title":"CNS Neurosci Ther"},{"key":"1011_CR196","doi-asserted-by":"publisher","DOI":"10.1056\/nejm199108153250704","author":"MK Sharief","year":"1991","unstructured":"Sharief MK, Hentges R (1991) Association between tumor Necrosis factor-\u03b1 and disease progression in patients with multiple sclerosis. N Engl J Med. https:\/\/doi.org\/10.1056\/nejm199108153250704","journal-title":"N Engl J Med"},{"issue":"8","key":"1011_CR197","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1007\/S10522-006-9033-Y","volume":"82","author":"PH Shih","year":"2006","unstructured":"Shih PH (2006) Yen GC (2006) differential expressions of antioxidant status in aging rats: the role of transcriptional factor Nrf2 and MAPK signaling pathway. Biogerontology 82(8):71\u201380. https:\/\/doi.org\/10.1007\/S10522-006-9033-Y","journal-title":"Biogerontology"},{"key":"1011_CR198","doi-asserted-by":"publisher","first-page":"683","DOI":"10.1001\/archneur.64.5.683","volume":"64","author":"NL Sicotte","year":"2007","unstructured":"Sicotte NL, Giesser BS, Tandon V et al (2007) Testosterone treatment in multiple sclerosis: a pilot study. Arch Neurol 64:683\u2013688. https:\/\/doi.org\/10.1001\/archneur.64.5.683","journal-title":"Arch Neurol"},{"key":"1011_CR199","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1016\/j.mce.2017.04.013","volume":"450","author":"F Silvagno","year":"2017","unstructured":"Silvagno F, Pescarmona G (2017) Spotlight on vitamin D receptor, lipid metabolism and mitochondria: some preliminary emerging issues. Mol Cell Endocrinol 450:24\u201331. https:\/\/doi.org\/10.1016\/j.mce.2017.04.013","journal-title":"Mol Cell Endocrinol"},{"key":"1011_CR200","doi-asserted-by":"publisher","first-page":"246","DOI":"10.1097\/WCO.0b013e3283533a7e","volume":"25","author":"KC Simon","year":"2012","unstructured":"Simon KC, Munger KL, Ascherio A (2012) Vitamin D and multiple sclerosis: epidemiology, immunology, and genetics. Curr Opin Neurol 25:246\u2013251. https:\/\/doi.org\/10.1097\/WCO.0b013e3283533a7e","journal-title":"Curr Opin Neurol"},{"key":"1011_CR201","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1159\/000444488","volume":"73","author":"\u015e \u015eim\u015fek","year":"2016","unstructured":"\u015eim\u015fek \u015e, Gen\u00e7o\u01e7lan S, Y\u00fcksel T et al (2016) Oxidative stress and DNA damage in untreated first-episode psychosis in adolescents. Neuropsychobiology 73:92\u201397. https:\/\/doi.org\/10.1159\/000444488","journal-title":"Neuropsychobiology"},{"key":"1011_CR202","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2019.00086","author":"M Siotto","year":"2019","unstructured":"Siotto M, Filippi MM, Simonelli I et al (2019) Oxidative stress related to iron metabolism in relapsing remitting multiple sclerosis patients with low disability. Front Neurosci. https:\/\/doi.org\/10.3389\/fnins.2019.00086","journal-title":"Front Neurosci"},{"key":"1011_CR203","doi-asserted-by":"publisher","first-page":"769","DOI":"10.1007\/s10072-019-04137-2","volume":"41","author":"C Skarlis","year":"2020","unstructured":"Skarlis C, Anagnostouli M (2020) The role of melatonin in multiple sclerosis. Neurol Sci 41:769\u2013781","journal-title":"Neurol Sci"},{"key":"1011_CR204","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1016\/j.msard.2019.01.023","volume":"29","author":"JL Soares","year":"2019","unstructured":"Soares JL, Oliveira EM, Pontillo A (2019) Variants in NLRP3 and NLRC4 inflammasome associate with susceptibility and severity of multiple sclerosis. Mult Scler Relat Disord 29:26\u201334. https:\/\/doi.org\/10.1016\/j.msard.2019.01.023","journal-title":"Mult Scler Relat Disord"},{"key":"1011_CR205","doi-asserted-by":"publisher","first-page":"616","DOI":"10.1016\/J.FREERADBIOMED.2017.09.005","volume":"112","author":"C Song","year":"2017","unstructured":"Song C, Zhao J, Fu B et al (2017) Melatonin-mediated upregulation of Sirt3 attenuates sodium fluoride-induced hepatotoxicity by activating the MT1-PI3K\/AKT-PGC-1\u03b1 signaling pathway. Free Radic Biol Med 112:616\u2013630. https:\/\/doi.org\/10.1016\/J.FREERADBIOMED.2017.09.005","journal-title":"Free Radic Biol Med"},{"key":"1011_CR206","doi-asserted-by":"publisher","first-page":"15","DOI":"10.2174\/1573395514666171226154300","volume":"14","author":"AP Soto-Brambila","year":"2017","unstructured":"Soto-Brambila AP, Gabriel Ortiz G, Rivero-Moragrega P et al (2017) Relapsing remitting multiple sclerosis and its relationship with the immune system and oxidative stress. Curr Immunol Rev 14:15\u201323. https:\/\/doi.org\/10.2174\/1573395514666171226154300","journal-title":"Curr Immunol Rev"},{"key":"1011_CR207","doi-asserted-by":"publisher","first-page":"880","DOI":"10.1002\/ANA.24287","volume":"76","author":"T Spelman","year":"2014","unstructured":"Spelman T, Gray O, Trojano M et al (2014) Seasonal variation of relapse rate in multiple sclerosis is latitude dependent. Ann Neurol 76:880\u2013890. https:\/\/doi.org\/10.1002\/ANA.24287","journal-title":"Ann Neurol"},{"key":"1011_CR208","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1093\/brain\/awf015","volume":"125","author":"C Stadelmann","year":"2002","unstructured":"Stadelmann C, Kerschensteiner M, Misgeld T et al (2002) BDNF and gp145trkB in multiple sclerosis brain lesions: neuroprotective interactions between immune and neuronal cells? Brain 125:75\u201385. https:\/\/doi.org\/10.1093\/brain\/awf015","journal-title":"Brain"},{"key":"1011_CR209","doi-asserted-by":"publisher","first-page":"521","DOI":"10.1210\/er.2007-0001","volume":"28","author":"RH Straub","year":"2007","unstructured":"Straub RH (2007) The complex role of estrogens in inflammation. Endocr Rev 28:521\u2013574. https:\/\/doi.org\/10.1210\/er.2007-0001","journal-title":"Endocr Rev"},{"key":"1011_CR210","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1002\/npr2.12125","volume":"40","author":"A Sugiyama","year":"2020","unstructured":"Sugiyama A, Kato H, Takakura H et al (2020) Effects of physical activity and melatonin on brain-derived neurotrophic factor and cytokine expression in the cerebellum of high-fat diet-fed rats. Neuropsychopharmacol Reports 40:291\u2013296. https:\/\/doi.org\/10.1002\/npr2.12125","journal-title":"Neuropsychopharmacol Reports"},{"key":"1011_CR211","doi-asserted-by":"publisher","first-page":"4410","DOI":"10.3390\/molecules25194410","volume":"25","author":"DX Tan","year":"2020","unstructured":"Tan DX, Hardeland R (2020) Targeting host defense system and rescuing compromised mitochondria to increase tolerance against pathogens by melatonin may impact outcome of deadly virus infection pertinent to COVID-19. Molecules 25:4410. https:\/\/doi.org\/10.3390\/molecules25194410","journal-title":"Molecules"},{"key":"1011_CR212","doi-asserted-by":"publisher","DOI":"10.3390\/MOLECULES23020301","author":"DX Tan","year":"2018","unstructured":"Tan DX, Xu B, Zhou X, Reiter RJ (2018) Pineal calcification, melatonin production, aging, associated health consequences and rejuvenation of the pineal gland. Mol A J Synth Chem Nat Prod Chem. https:\/\/doi.org\/10.3390\/MOLECULES23020301","journal-title":"Mol A J Synth Chem Nat Prod Chem"},{"key":"1011_CR213","doi-asserted-by":"publisher","DOI":"10.1007\/s11064-010-0172-9","author":"I Tasset","year":"2010","unstructured":"Tasset I, Drucker-Col\u00edn R, Pe\u00f1a J et al (2010) Antioxidant-like effects and protective action of transcranial magnetic stimulation in depression caused by olfactory bulbectomy. Neurochem Res. https:\/\/doi.org\/10.1007\/s11064-010-0172-9","journal-title":"Neurochem Res"},{"key":"1011_CR214","doi-asserted-by":"publisher","first-page":"1944","DOI":"10.1016\/j.pnpbp.2011.09.005","volume":"35","author":"I Tasset","year":"2011","unstructured":"Tasset I, Ag\u00fcera E, Olmo-Camacho R et al (2011) Melatonin improves 3-nitropropionic acid induced behavioral alterations and neurotrophic factors levels. Prog Neuro-Psychopharmacology Biol Psychiatry 35:1944\u20131949. https:\/\/doi.org\/10.1016\/j.pnpbp.2011.09.005","journal-title":"Prog Neuro-Psychopharmacology Biol Psychiatry"},{"key":"1011_CR215","doi-asserted-by":"publisher","first-page":"440","DOI":"10.1016\/J.CLINBIOCHEM.2012.01.023","volume":"45","author":"I Tasset","year":"2012","unstructured":"Tasset I, Ag\u00fcera E, S\u00e1nchez-L\u00f3pez F et al (2012) Peripheral oxidative stress in relapsing-remitting multiple sclerosis. Clin Biochem 45:440\u2013444. https:\/\/doi.org\/10.1016\/J.CLINBIOCHEM.2012.01.023","journal-title":"Clin Biochem"},{"key":"1011_CR216","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1177\/1352458514540843","volume":"21","author":"J Th\u00f6ne","year":"2015","unstructured":"Th\u00f6ne J, Kollar S, Nousome D et al (2015) Serum anti-M\u00fcllerian hormone levels in reproductive-age women with relapsing-remitting multiple sclerosis. Mult Scler J 21:41\u201347. https:\/\/doi.org\/10.1177\/1352458514540843","journal-title":"Mult Scler J"},{"key":"1011_CR217","doi-asserted-by":"publisher","first-page":"47","DOI":"10.3306\/MEDICINABALEAR.32.02.47","volume":"32","author":"M Torrens-Mas","year":"2017","unstructured":"Torrens-Mas M, Roca P, Sastre-Serra J, Margalida Torrens-Mas C (2017) Importancia de la sirtuina 3 en el estr\u00e9s oxidativo y el c\u00e1ncer Role of sirtuin 3 in oxidative stress and cancer. Med Balear 32:47\u201352. https:\/\/doi.org\/10.3306\/MEDICINABALEAR.32.02.47","journal-title":"Med Balear"},{"key":"1011_CR218","doi-asserted-by":"publisher","first-page":"1343","DOI":"10.1089\/ARS.2007.1957","volume":"10","author":"D Trachootham","year":"2008","unstructured":"Trachootham D, Lu W, Ogasawara MA et al (2008) Redox regulation of cell survival. Antioxid Redox Signal 10:1343. https:\/\/doi.org\/10.1089\/ARS.2007.1957","journal-title":"Antioxid Redox Signal"},{"key":"1011_CR219","doi-asserted-by":"publisher","first-page":"252","DOI":"10.1111\/j.1600-079X.2004.00163.x","volume":"37","author":"I T\u00fanez","year":"2004","unstructured":"T\u00fanez I, Montilla P, Mu\u00f1oz MDC et al (2004) Protective effect of melatonin on 3-nitropropionic acid-induced oxidative stress in synaptosomes in an animal model of Huntington\u2019s disease. J Pineal Res 37:252\u2013256. https:\/\/doi.org\/10.1111\/j.1600-079X.2004.00163.x","journal-title":"J Pineal Res"},{"key":"1011_CR220","doi-asserted-by":"publisher","first-page":"858","DOI":"10.3389\/fphys.2018.00858","volume":"9","author":"G Valacchi","year":"2018","unstructured":"Valacchi G, Virgili F, Cervellati C, Pecorelli A (2018) OxInflammation: from subclinical condition to pathological biomarker. Front Physiol 9:858. https:\/\/doi.org\/10.3389\/fphys.2018.00858","journal-title":"Front Physiol"},{"key":"1011_CR221","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2017.01081","author":"WJ van den Hoogen","year":"2017","unstructured":"van den Hoogen WJ, Laman JD, Hart T, BA, (2017) Modulation of multiple sclerosis and its animal model experimental autoimmune encephalomyelitis by food and gut microbiota. Front Immunol. https:\/\/doi.org\/10.3389\/fimmu.2017.01081","journal-title":"Front Immunol"},{"key":"1011_CR222","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/873278","author":"R Villanueva","year":"2013","unstructured":"Villanueva R (2013) Neurobiology of major depressive disorder. Neural Plast. https:\/\/doi.org\/10.1155\/2013\/873278","journal-title":"Neural Plast"},{"key":"1011_CR223","doi-asserted-by":"publisher","DOI":"10.1002\/mds.20628","author":"JM Walshe","year":"2005","unstructured":"Walshe JM (2005) Diagnostic significance of reduced serum caeruloplasmin concentration in neurological disease. Mov Disord. https:\/\/doi.org\/10.1002\/mds.20628","journal-title":"Mov Disord"},{"key":"1011_CR224","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1111\/j.1755-5949.2009.00105.x","volume":"15","author":"X Wang","year":"2009","unstructured":"Wang X (2009) The antiapoptotic activity of melatonin in neurodegenerative diseases. CNS Neurosci Ther 15:345. https:\/\/doi.org\/10.1111\/j.1755-5949.2009.00105.x","journal-title":"CNS Neurosci Ther"},{"key":"1011_CR225","doi-asserted-by":"publisher","first-page":"1363","DOI":"10.1007\/S10753-013-9676-1","volume":"36","author":"Y Wang","year":"2013","unstructured":"Wang Y, Liu X, Wang W et al (2013) The expression of inflammatory cytokines on the aorta endothelia are up-regulated in pinealectomized rats. Inflammation 36:1363\u20131373. https:\/\/doi.org\/10.1007\/S10753-013-9676-1","journal-title":"Inflammation"},{"key":"1011_CR226","doi-asserted-by":"publisher","DOI":"10.1111\/jpi.12666","author":"Y Wang","year":"2020","unstructured":"Wang Y, Han D, Zhou T et al (2020) Melatonin ameliorates aortic valve calcification via the regulation of circular RNA CircRIC3\/miR-204-5p\/DPP4 signaling in valvular interstitial cells. J Pineal Res. https:\/\/doi.org\/10.1111\/jpi.12666","journal-title":"J Pineal Res"},{"key":"1011_CR227","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1177\/1352458517737393","volume":"24","author":"E Waubant","year":"2018","unstructured":"Waubant E (2018) Effect of puberty on multiple sclerosis risk and course. Mult Scler 24:32\u201335. https:\/\/doi.org\/10.1177\/1352458517737393","journal-title":"Mult Scler"},{"key":"1011_CR228","doi-asserted-by":"publisher","first-page":"683","DOI":"10.1016\/j.coi.2013.09.009","volume":"25","author":"H Wekerle","year":"2013","unstructured":"Wekerle H, Berer K, Krishnamoorthy G (2013) Remote control-triggering of brain autoimmune disease in the gut. Curr Opin Immunol 25:683\u2013689. https:\/\/doi.org\/10.1016\/j.coi.2013.09.009","journal-title":"Curr Opin Immunol"},{"key":"1011_CR229","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2017-317493","author":"JMA Wijnands","year":"2018","unstructured":"Wijnands JMA, Zhu F, Kingwell E et al (2018) Disease-modifying drugs for multiple sclerosis and infection risk: a cohort study. J Neurol Neurosurg Psychiatry. https:\/\/doi.org\/10.1136\/jnnp-2017-317493","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"1011_CR230","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-020-09822-3","author":"MD Willis","year":"2020","unstructured":"Willis MD, Robertson NP (2020) Multiple sclerosis and the risk of infection: considerations in the threat of the novel coronavirus, COVID-19\/SARS-CoV-2. J Neurol. https:\/\/doi.org\/10.1007\/s00415-020-09822-3","journal-title":"J Neurol"},{"key":"1011_CR231","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3390\/antiox10010047","volume":"10","author":"P Wongchitrat","year":"2021","unstructured":"Wongchitrat P, Shukla M, Sharma R et al (2021) Role of melatonin on virus-induced neuropathogenesis\u2014a concomitant therapeutic strategy to understand SARS-CoV-2 infection. Antioxidants 10:1\u201331. https:\/\/doi.org\/10.3390\/antiox10010047","journal-title":"Antioxidants"},{"key":"1011_CR232","doi-asserted-by":"publisher","first-page":"4789","DOI":"10.1210\/jcem.86.10.7912","volume":"86","author":"MMM Woo","year":"2001","unstructured":"Woo MMM, Tai CJ, Kang SK et al (2001) Direct action of melatonin in human granulosa-luteal cells. J Clin Endocrinol Metab 86:4789\u20134797. https:\/\/doi.org\/10.1210\/jcem.86.10.7912","journal-title":"J Clin Endocrinol Metab"},{"key":"1011_CR233","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2019.117067","author":"HHM Wu","year":"2019","unstructured":"Wu HHM, Xie QQM, Zhao CCC et al (2019) Melatonin biosynthesis restored by CpG oligodeoxynucleotides attenuates allergic airway inflammation via regulating NLRP3 inflammasome. Life Sci. https:\/\/doi.org\/10.1016\/j.lfs.2019.117067","journal-title":"Life Sci"},{"key":"1011_CR234","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-34011-8","author":"X Xu","year":"2018","unstructured":"Xu X, Wang G, Ai L et al (2018) Melatonin suppresses TLR9-triggered proinflammatory cytokine production in macrophages by inhibiting ERK1\/2 and AKT activation. Sci Rep. https:\/\/doi.org\/10.1038\/s41598-018-34011-8","journal-title":"Sci Rep"},{"key":"1011_CR235","doi-asserted-by":"publisher","first-page":"607","DOI":"10.1007\/s40261-019-00793-6","volume":"39","author":"M Yeganeh-Salehpour","year":"2019","unstructured":"Yeganeh-Salehpour M, Mollica A, Momtaz S et al (2019) Melatonin and multiple sclerosis: from plausible neuropharmacological mechanisms of action to experimental and clinical evidence. Clin Drug Investig 39:607\u2013624. https:\/\/doi.org\/10.1007\/s40261-019-00793-6","journal-title":"Clin Drug Investig"},{"key":"1011_CR236","doi-asserted-by":"publisher","DOI":"10.3892\/ETM.2021.10828","author":"S Yi","year":"2021","unstructured":"Yi S, Yang Y (2021) Melatonin attenuates low shear stress-induced pyroptosis and endothelial cell dysfunction via the ROR\u03b1\/miR-223\/STAT-3 signalling pathway. Exp Ther Med. https:\/\/doi.org\/10.3892\/ETM.2021.10828","journal-title":"Exp Ther Med"},{"key":"1011_CR237","doi-asserted-by":"publisher","first-page":"649","DOI":"10.18502\/ijaai.v18i6.2177","volume":"18","author":"M Yosefifard","year":"2019","unstructured":"Yosefifard M, Vaezi G, Malekirad AA et al (2019) A randomized control trial study to determine the effect of melatonin on serum levels of IL-1\u03b2 and TNF-\u03b1 in patients with multiple sclerosis. Iran J Allergy, Asthma Immunol 18:649\u2013654. https:\/\/doi.org\/10.18502\/ijaai.v18i6.2177","journal-title":"Iran J Allergy, Asthma Immunol"},{"key":"1011_CR238","doi-asserted-by":"publisher","first-page":"19","DOI":"10.32598\/ijt.14.1.19","volume":"14","author":"M Yosefi-Fard","year":"2020","unstructured":"Yosefi-Fard M, Vaezi G, Maleki-Rad AA et al (2020) Effect of melatonin on serum levels of inf-1\u00df and vitamin b12 in patients with multiple sclerosis: a randomized controlled trial. Iran J Toxicol 14:19\u201324. https:\/\/doi.org\/10.32598\/ijt.14.1.19","journal-title":"Iran J Toxicol"},{"key":"1011_CR239","doi-asserted-by":"publisher","DOI":"10.1126\/science.1243884","author":"X Yu","year":"2013","unstructured":"Yu X, Rollins D, Ruhn KA et al (2013) TH17 cell differentiation is regulated by the circadian clock. Science (80-). https:\/\/doi.org\/10.1126\/science.1243884","journal-title":"Science (80-)"},{"key":"1011_CR240","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0178525","author":"GM Yu","year":"2017","unstructured":"Yu GM, Kubota H, Okita M, Maeda T (2017) The anti-inflammatory and antioxidant effects of melatonin on LPS-stimulated bovine mammary epithelial cells. PLoS ONE. https:\/\/doi.org\/10.1371\/journal.pone.0178525","journal-title":"PLoS ONE"},{"key":"1011_CR241","doi-asserted-by":"publisher","first-page":"1507","DOI":"10.4103\/1673-5374.237109","volume":"13","author":"Y Yue","year":"2018","unstructured":"Yue Y, Stone S, Lin W (2018) Role of nuclear factor \u03bab in multiple sclerosis and experimental autoimmune encephalomyelitis. Neural Regen Res 13:1507\u20131515. https:\/\/doi.org\/10.4103\/1673-5374.237109","journal-title":"Neural Regen Res"},{"key":"1011_CR242","doi-asserted-by":"publisher","DOI":"10.1093\/braincomms\/fcaa185","author":"B Zeydan","year":"2020","unstructured":"Zeydan B, Atkinson EJ, Weis DM et al (2020) Reproductive history and progressive multiple sclerosis risk in women. Brain Commun. https:\/\/doi.org\/10.1093\/braincomms\/fcaa185","journal-title":"Brain Commun"},{"key":"1011_CR243","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1016\/J.BBR.2013.07.051","volume":"256","author":"L Zhang","year":"2013","unstructured":"Zhang L, Zhang H, Liang X et al (2013) Melatonin ameliorates cognitive impairment induced by sleep deprivation in rats: role of oxidative stress, BDNF and CaMKII. Behav Brain Res 256:72\u201381. https:\/\/doi.org\/10.1016\/J.BBR.2013.07.051","journal-title":"Behav Brain Res"},{"key":"1011_CR244","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2020.117583","volume":"250","author":"R Zhang","year":"2020","unstructured":"Zhang R, Wang X, Ni L et al (2020) COVID-19: melatonin as a potential adjuvant treatment. Life Sci 250:117583. https:\/\/doi.org\/10.1016\/j.lfs.2020.117583","journal-title":"Life Sci"},{"key":"1011_CR245","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.cytogfr.2019.07.002","volume":"48","author":"C Zhao","year":"2019","unstructured":"Zhao C, Wang P, Mao YM et al (2019) Potential role of melatonin in autoimmune diseases. Cytokine Growth Factor Rev 48:1\u201310. https:\/\/doi.org\/10.1016\/j.cytogfr.2019.07.002","journal-title":"Cytokine Growth Factor Rev"},{"key":"1011_CR246","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/4019619","author":"W Zhou","year":"2019","unstructured":"Zhou W, Liu Y, Shen J et al (2019) Melatonin increases bone mass around the prostheses of OVX rats by ameliorating mitochondrial oxidative stress via the SIRT3\/SOD2 signaling pathway. Oxid Med Cell Longev. https:\/\/doi.org\/10.1155\/2019\/4019619","journal-title":"Oxid Med Cell Longev"},{"key":"1011_CR247","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.3000970","author":"Y Zhou","year":"2020","unstructured":"Zhou Y, Hou Y, Shen J et al (2020) A network medicine approach to investigation and population-based validation of disease manifestations and drug repurposing for COVID-19. PLoS Biol. https:\/\/doi.org\/10.1371\/journal.pbio.3000970","journal-title":"PLoS Biol"}],"container-title":["Inflammopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10787-022-01011-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10787-022-01011-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10787-022-01011-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,9]],"date-time":"2025-04-09T08:36:05Z","timestamp":1744187765000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10787-022-01011-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6,5]]},"references-count":248,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2022,10]]}},"alternative-id":["1011"],"URL":"https:\/\/doi.org\/10.1007\/s10787-022-01011-0","relation":{},"ISSN":["0925-4692","1568-5608"],"issn-type":[{"value":"0925-4692","type":"print"},{"value":"1568-5608","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,6,5]]},"assertion":[{"value":"5 January 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 May 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 June 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors have no relevant financial or non-financial interests to disclose.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}