{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T02:06:50Z","timestamp":1791770810466,"version":"4.3.4"},"reference-count":35,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2022,8,9]],"date-time":"2022-08-09T00:00:00Z","timestamp":1660003200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2022,8,9]],"date-time":"2022-08-09T00:00:00Z","timestamp":1660003200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100006606","name":"Natural Science Foundation of Tianjin City","doi-asserted-by":"publisher","award":["16JCQNJC13800"],"award-info":[{"award-number":["16JCQNJC13800"]}],"id":[{"id":"10.13039\/501100006606","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Inflammopharmacol"],"published-print":{"date-parts":[[2022,10]]},"DOI":"10.1007\/s10787-022-01044-5","type":"journal-article","created":{"date-parts":[[2022,8,9]],"date-time":"2022-08-09T04:02:52Z","timestamp":1660017772000},"page":"1717-1728","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Therapeutic effect of the sulforaphane derivative JY4 on ulcerative colitis through the NF-\u03baB-p65 pathway"],"prefix":"10.1007","volume":"30","author":[{"given":"Xiu-Juan","family":"Zhao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-Ran","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen-Fei","family":"Bai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tong-Yan","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Fen","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tong-Xin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9810-0637","authenticated-orcid":false,"given":"Cui-Gai","family":"Bai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,8,9]]},"reference":[{"key":"1044_CR1","doi-asserted-by":"publisher","first-page":"591","DOI":"10.1111\/j.1365-2796.2008.01953.x","volume":"263","author":"I Atreya","year":"2008","unstructured":"Atreya I, Atreya R, Neurath MF (2008) NF-kappaB in inflammatory bowel disease. J Intern Med 263:591\u2013596","journal-title":"J Intern Med"},{"key":"1044_CR2","doi-asserted-by":"publisher","first-page":"521","DOI":"10.1038\/nri1132","volume":"3","author":"G Bouma","year":"2003","unstructured":"Bouma G, Strober W (2003) The immunological and genetic basis of inflammatory bowel disease. Nat Rev Immunol 3:521\u2013533","journal-title":"Nat Rev Immunol"},{"key":"1044_CR3","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1007\/s12079-017-0401-y","volume":"12","author":"R Bayat Mokhtari","year":"2017","unstructured":"Bayat Mokhtari R, Baluch N, Homayouni TS, Morgatskaya E, Kumar S, Kazemi P et al (2017) The role of Sulforaphane in cancer chemoprevention and health benefits: a mini-review. J Cell Commun Signal 12:91\u2013101","journal-title":"J Cell Commun Signal"},{"key":"1044_CR4","doi-asserted-by":"publisher","first-page":"860","DOI":"10.1038\/nature01322","volume":"420","author":"LM Coussens","year":"2002","unstructured":"Coussens LM, Werb Z (2002) Inflammation and cancer. Nature 420:860\u2013867","journal-title":"Nature"},{"key":"1044_CR5","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1016\/j.jnutbio.2013.10.007","volume":"25","author":"KM Choi","year":"2014","unstructured":"Choi KM, Lee YS, Kim W, Kim SJ, Shin KO, Yu JY et al (2014) Sulforaphane attenuates obesity by inhibiting adipogenesis and activating the AMPK pathway in obese mice. J Nutr Biochem 25:201\u2013207","journal-title":"J Nutr Biochem"},{"key":"1044_CR6","doi-asserted-by":"publisher","first-page":"426","DOI":"10.1016\/j.jff.2015.08.030","volume":"19","author":"R Checker","year":"2015","unstructured":"Checker R, Gambhir L, Thoh M, Sharma D, Sandur SK (2015) Sulforaphane, a naturally occurring isothiocyanate, exhibits anti-inflammatory effects by targeting GSK3\u03b2\/Nrf-2 and NF-\u03baB pathways in T cells. J Funct Foods 19:426\u2013438","journal-title":"J Funct Foods"},{"key":"1044_CR7","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1007\/s12072-014-9604-y","volume":"9","author":"X Chi","year":"2015","unstructured":"Chi X, Zhang R, Shen N, Jin Y, Alina A, Yang S et al (2015) Sulforaphane reduces apoptosis and oncosis along with protecting liver injury-induced ischemic reperfusion by activating the Nrf2\/ARE pathway. Hepatol Int 9:321\u2013329","journal-title":"Hepatol Int"},{"key":"1044_CR8","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1016\/j.tifs.2017.02.002","volume":"3","author":"AT Dinkova-Kostova","year":"2017","unstructured":"Dinkova-Kostova AT, Fahey JW, Kostov RV, Kensler TW (2017) KEAP1 and done? Targeting the NRF2 pathway with sulforaphane. Trends Food Sci Technol 3:257\u2013269","journal-title":"Trends Food Sci Technol"},{"key":"1044_CR9","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1038\/mi.2008.40","volume":"10","author":"IJ Fuss","year":"2008","unstructured":"Fuss IJ, Strober W (2008) The role of IL-13 and NK T cells in experimental and human ulcerative colitis. Mucosal Immunol 10:31\u201333","journal-title":"Mucosal Immunol"},{"key":"1044_CR10","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1016\/j.jff.2014.04.015","volume":"9","author":"L Guo","year":"2014","unstructured":"Guo L, Yang R, Wang Z, Guo Q, Gu Z (2014) Gl32ucoraphanin, sulforaphane and myrosinase activity in germinating broccoli sprouts as affected by growth temperature and plant organs. J Funct Foods 9:70\u201377","journal-title":"J Funct Foods"},{"key":"1044_CR11","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1189\/jlb.3A0415-155RR","volume":"99","author":"AJ Greaney","year":"2016","unstructured":"Greaney AJ, Maier NK, Leppla SH, Moayeri M (2016) Sulforaphane inhibits multiple inflammasomes through an Nrf2-independent mechanism. J Leukocyte Biol 99:1\u201311","journal-title":"J Leukocyte Biol"},{"key":"1044_CR12","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1007\/s00535-003-1139-2","volume":"38","author":"T Hibi","year":"2003","unstructured":"Hibi T, Inoue N, Ogata H, Naganuma M (2003) Introduction and overview: recent advances in the immunotherapy of inflammatory bowel disease. J Gastroenterol 38:36\u201342","journal-title":"J Gastroenterol"},{"key":"1044_CR13","doi-asserted-by":"publisher","first-page":"484","DOI":"10.1152\/ajpgi.00477.2011","volume":"302","author":"SA Ingersoll","year":"2012","unstructured":"Ingersoll SA, Ayyadurai S, Charania MA, Laroui H, Yan Y, Merlin D (2012) The role and pathophysiological relevance of membrane transporter PepT1 in intestinal inflammation and inflammatory bowel disease. Am J Physiol Gastrointest Liver Physiol 302:484\u2013492","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"1044_CR14","first-page":"734","volume":"28","author":"Y Jiang","year":"2018","unstructured":"Jiang Y, Li HY, Li XH, Lu J, Zhang Q, Bai CG et al (2018) Therapeutic effects of isothiocyanate prodrugs on rheumatoid arthritis. Bioorg Med Chem Lett 28:734\u2013741","journal-title":"Bioorg Med Chem Lett"},{"key":"1044_CR15","doi-asserted-by":"publisher","first-page":"573","DOI":"10.1146\/annurev-immunol-030409-101225","volume":"28","author":"A Kaser","year":"2010","unstructured":"Kaser A, Zeissig S, Blumberg RS (2010) Inflammatory bowel disease. Annu Rev Immunol 28:573\u2013621","journal-title":"Annu Rev Immunol"},{"key":"1044_CR16","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1016\/j.neuint.2016.08.011","volume":"100","author":"L Kong","year":"2016","unstructured":"Kong L, Liu B, Zhang C, Wang B, Wang H, Song X et al (2016) The therapeutic potential of sulforaphane on light-induced photoreceptor degeneration through antiapoptosis and antioxidant protection. Neurochem Int 100:52\u201361","journal-title":"Neurochem Int"},{"key":"1044_CR17","first-page":"1825","volume":"91","author":"WD Liang","year":"2011","unstructured":"Liang WD, Li JS, Li KS, Jin J, Yan J, Yang JF et al (2011) Association of IL-8 gene polymorphisms with inflammatory bowel disease in Chinese patients. Zhonghua Yi Xue Za Zhi 91:1825\u20131829","journal-title":"Zhonghua Yi Xue Za Zhi"},{"key":"1044_CR18","doi-asserted-by":"publisher","first-page":"492","DOI":"10.1016\/j.bbrc.2012.08.107","volume":"426","author":"JH Lee","year":"2012","unstructured":"Lee JH, Moon MH, Jeong JK, Park YG, Lee YJ, Seol JW et al (2012) Sulforaphane induced adipolysis via hormone sensitive lipase activation, regulated by AMPK signaling pathway. Biochem Bioph Res Co 426:492\u2013497","journal-title":"Biochem Bioph Res Co"},{"key":"1044_CR19","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1016\/j.expneurol.2013.10.002","volume":"250","author":"B Li","year":"2013","unstructured":"Li B, Cui W, Liu J, Li R, Liu Q, Xie XH et al (2013) Sulforaphane ameliorates the development of experimental autoimmune encephalomyelitis by antagonizing oxidative stress and Th17-related inflammation in mice. Exp Neurol 250:239\u2013249","journal-title":"Exp Neurol"},{"key":"1044_CR20","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1007\/s00228-012-1389-0","volume":"69","author":"D Lacruz-Guzman","year":"2013","unstructured":"Lacruz-Guzman D, Torres-Moreno D, Pedrero F, Romero-Cara P, Garcia-Tercero I, Trujillo-Santos J et al (2013) Influence of polymorphisms and TNF and IL1beta serum concentration on the infliximab response in Crohn\u2019s disease and ulcerative colitis. Eur J Clin Pharmacol 69:431\u2013438","journal-title":"Eur J Clin Pharmacol"},{"key":"1044_CR21","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1146\/annurev-pathol-012615-044152","volume":"11","author":"TC Liu","year":"2016","unstructured":"Liu TC, Stappenbeck TS (2016) Enetics and pathogenesis of inflammatory bowel disease. Annu Rev Pathol Mech Dis 11:127\u2013148","journal-title":"Annu Rev Pathol Mech Dis"},{"key":"1044_CR22","doi-asserted-by":"publisher","first-page":"824","DOI":"10.1016\/j.jnutbio.2014.03.011","volume":"25","author":"P Nallasamy","year":"2014","unstructured":"Nallasamy P, Si H, Babu PVA, Pan D, Fu Y, Brooke EA et al (2014) Sulforaphane reduces vascular inflammation in mice and prevents TNF-\u03b1-induced monocyte adhesion to primary endothelial cells through interfering with the NF-\u03baB pathway. J Nutr Biochem 25:824\u2013833","journal-title":"J Nutr Biochem"},{"key":"1044_CR23","doi-asserted-by":"publisher","first-page":"114186","DOI":"10.1371\/journal.pone.0114186","volume":"9","author":"H Pan","year":"2014","unstructured":"Pan H, He M, Liu R, Brecha NC, Yu ACH, Pu M et al (2014) Sulforaphane protects rodent retinas against ischemia-reperfusion injury through the activation of the Nrf2\/HO-1 antioxidant pathway. PLoS ONE 9:114186\u2013114210","journal-title":"PLoS ONE"},{"key":"1044_CR24","doi-asserted-by":"publisher","first-page":"182","DOI":"10.3892\/ijmm.2015.2396","volume":"37","author":"T Qi","year":"2016","unstructured":"Qi T, Xu F, Yan X, Li S, Li H (2016) Sulforaphane exerts anti-inflammatory effects against lipopolysaccharide-induced acute lung injury in mice through the Nrf2\/ARE pathway. Int J Mol Med 37:182\u2013188","journal-title":"Int J Mol Med"},{"key":"1044_CR25","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1016\/S0016-5085(98)70202-1","volume":"115","author":"G Rogler","year":"1998","unstructured":"Rogler G, Brand K, Vogl D, Page S, Hofmeister R, Andus T et al (1998) Nuclear factor kappaB is activated in macropHages and epithelial cells of inflamed intestinal mucosa. Gastroenterology 115:357\u2013369","journal-title":"Gastroenterology"},{"key":"1044_CR26","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1007\/s10620-006-9322-y","volume":"52","author":"KP Reddy","year":"2007","unstructured":"Reddy KP, Markowitz JE, Ruchelli ED, Baldassano RN, Brown KA (2007) Lamina propria and circulating interleukin-8 in newly and previously diagnosed pediatric inflammatory bowel disease patients. Dig Dis Sci 52:365\u2013372","journal-title":"Dig Dis Sci"},{"key":"1044_CR27","doi-asserted-by":"publisher","first-page":"440","DOI":"10.1016\/j.intimp.2014.12.037","volume":"24","author":"SA Reddy","year":"2015","unstructured":"Reddy SA, Shelar SB, Dang TM, Lee BNC, Yang H, Ong SM et al (2015) Sulforaphane and its methylcarbonyl analogs inhibit the LPS-stimulated inflammatory response in human monocytes through modulating cytokine production, suppressing chemotactic migration and phagocytosis in a NF-\u03baB- and MAPK-dependent manner. Int Immunopharmacol 24:440\u2013450","journal-title":"Int Immunopharmacol"},{"key":"1044_CR28","doi-asserted-by":"publisher","first-page":"3399","DOI":"10.1084\/jem.20170261","volume":"214","author":"BM Rezende","year":"2017","unstructured":"Rezende BM, Athayde RM, Gon\u00e7alves WA, Resende CB, de Tol\u00eado T, Bernardes P, Perez DA et al (2017) Inhibition of 5-lipoxygenase alleviates graft-versus-host disease. J Exp Med 214:3399\u20133415","journal-title":"J Exp Med"},{"key":"1044_CR29","doi-asserted-by":"publisher","first-page":"426","DOI":"10.1177\/1535370215609695","volume":"241","author":"GS Shehatou","year":"2016","unstructured":"Shehatou GS, Suddek GM (2016) Sulforaphane attenuates the development of atherosclerosis and improves endothelial dysfunction in hypercholesterolemic rabbits. Exp Biol Med 241:426\u2013436","journal-title":"Exp Biol Med"},{"key":"1044_CR30","doi-asserted-by":"publisher","first-page":"185","DOI":"10.2147\/DDDT.S11290","volume":"5","author":"JK Triantafillidis","year":"2011","unstructured":"Triantafillidis JK, Merikas E, Georgopoulos F (2011) Current and emerging drugs for the treatment of inflammatory bowel disease. Drug Des Dev Ther 5:185\u2013210","journal-title":"Drug Des Dev Ther"},{"key":"1044_CR31","doi-asserted-by":"publisher","first-page":"21132","DOI":"10.1074\/jbc.273.33.21132","volume":"273","author":"M Uhlik","year":"1998","unstructured":"Uhlik M, Good L, Xiao G, Harhaj EW, Zandi E, Karin M et al (1998) NF-\u03baB-inducing Kinase and I\u03baB kinase participate in human T-cell leukemia virus I tax-mediated NF-\u03baB activation. J Biol Chem 273:21132\u201321136","journal-title":"J Biol Chem"},{"key":"1044_CR32","doi-asserted-by":"publisher","first-page":"1746","DOI":"10.1007\/s12325-018-0795-9","volume":"35","author":"R Weisshof","year":"2018","unstructured":"Weisshof R, Jurdi EI, Zmeter N, Rubin DT (2018) Emerging therapies for inflammatory bowel disease. Adv Ther 35:1746\u20131762","journal-title":"Adv Ther"},{"key":"1044_CR33","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1007\/s11882-012-0300-5","volume":"13","author":"A Zubair","year":"2013","unstructured":"Zubair A, Frieri M (2013) Role of nuclear factor-\u0138B in breast and colorectal cancer. Curr Aller Asthma Rep 13:44\u201349","journal-title":"Curr Aller Asthma Rep"},{"key":"1044_CR34","doi-asserted-by":"publisher","first-page":"91","DOI":"10.3748\/wjg.v20.i1.91","volume":"20","author":"YZ Zhang","year":"2014","unstructured":"Zhang YZ, Li YY (2014) Inflammatory bowel disease: pathogenesis. World J Gastroenterol 20:91\u201399","journal-title":"World J Gastroenterol"},{"key":"1044_CR35","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1016\/j.jnutbio.2016.10.004","volume":"39","author":"JC Zhang","year":"2017","unstructured":"Zhang JC, Yao W, Dong C, Yang C, Ren Q, Ma M et al (2017) Prophylactic effects of sulforaphane on depression-like behavior and dendritic changes in mice after inflammation. J Nutr Biochem 39:134\u2013144","journal-title":"J Nutr Biochem"}],"container-title":["Inflammopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10787-022-01044-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10787-022-01044-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10787-022-01044-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,9,22]],"date-time":"2022-09-22T11:29:34Z","timestamp":1663846174000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10787-022-01044-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8,9]]},"references-count":35,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2022,10]]}},"alternative-id":["1044"],"URL":"https:\/\/doi.org\/10.1007\/s10787-022-01044-5","relation":{},"ISSN":["0925-4692","1568-5608"],"issn-type":[{"value":"0925-4692","type":"print"},{"value":"1568-5608","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,8,9]]},"assertion":[{"value":"23 March 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 June 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 August 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"All experiments using animals reported herein were approved by the Animal Care and Use Committee of Tianjin international Joint Academy of BioMedicine (Tjab 2017\u20130301).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}]}}