{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T03:08:20Z","timestamp":1773112100863,"version":"3.50.1"},"reference-count":90,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2022,8,27]],"date-time":"2022-08-27T00:00:00Z","timestamp":1661558400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2022,8,27]],"date-time":"2022-08-27T00:00:00Z","timestamp":1661558400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Inflammopharmacol"],"published-print":{"date-parts":[[2022,10]]},"DOI":"10.1007\/s10787-022-01051-6","type":"journal-article","created":{"date-parts":[[2022,8,27]],"date-time":"2022-08-27T06:05:01Z","timestamp":1661580301000},"page":"1555-1567","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Exploring the pivotal role of endothelin in rheumatoid arthritis"],"prefix":"10.1007","volume":"30","author":[{"given":"Aayush","family":"Sehgal","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0993-7708","authenticated-orcid":false,"given":"Tapan","family":"Behl","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sukhbir","family":"Singh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neelam","family":"Sharma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammed","family":"Albratty","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hassan A.","family":"Alhazmi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdulkarim M.","family":"Meraya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lotfi","family":"Aleya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aditi","family":"Sharma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simona","family":"Bungau","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2022,8,27]]},"reference":[{"key":"1051_CR1","unstructured":"Alvarez-Cienfuegos A, Cantero-Nieto L, Garc\u00eda-G\u00f3mez JA, R\u00edos-Fern\u00e1ndez R, Mart\u00edn J, Gonz\u00e1lez-Gay MA, Ortego-Centeno N. (2019). Endothelin-1 serum levels in women with rheumatoid arthritis. Acta Reumatol Port 44:250\u2013257. http:\/\/hdl.handle.net\/10261\/226842"},{"key":"1051_CR2","doi-asserted-by":"publisher","first-page":"2097","DOI":"10.1084\/jem.182.6.2097","volume":"182","author":"AR Amin","year":"1995","unstructured":"Amin AR, Di Cesare PE, Vyas P, Attur M, Tzeng E, Billiar TR, Stuchin SA, Abramson SB (1995) The expression and regulation of nitric oxide synthase in human osteoarthritis-affected chondrocytes: evidence for up-regulated neuronal nitric oxide synthase. J Exp Med 182:2097\u20132102. https:\/\/doi.org\/10.1084\/jem.182.6.2097","journal-title":"J Exp Med"},{"key":"1051_CR3","first-page":"1306","volume":"57","author":"A Bagnato","year":"1997","unstructured":"Bagnato A, Tecce R, Di Castro V, Catt KJ (1997) Activation of mitogenic signaling by endothelin 1 in ovarian carcinoma cells. Cancer Res 57:1306\u20131311","journal-title":"Cancer Res"},{"key":"1051_CR4","doi-asserted-by":"publisher","first-page":"522","DOI":"10.3390\/ijms18030522","volume":"18","author":"B Bakrania","year":"2017","unstructured":"Bakrania B, Duncan J, Warrington JP, Granger JP (2017) The endothelin type A receptor as a potential therapeutic target in preeclampsia. Int J Mol Sci 18:522. https:\/\/doi.org\/10.3390\/ijms18030522","journal-title":"Int J Mol Sci"},{"key":"1051_CR5","doi-asserted-by":"publisher","DOI":"10.1038\/srep27236","author":"K Batumalaie","year":"2016","unstructured":"Batumalaie K, Amin MA, Murugan DD, Sattar MZ, Abdullah NA, Withaferin A (2016) Protects against palmitic acid-induced endothelial insulin resistance and dysfunction through suppression of oxidative stress and inflammation. Sci Rep. https:\/\/doi.org\/10.1038\/srep27236 (PMID: 27250532; PMCID: PMC4890118)","journal-title":"Sci Rep"},{"key":"1051_CR6","volume-title":"14 Sarafotoxins, the Snake Venom homologs of the endothelins","author":"SP Mackessy","year":"2021","unstructured":"Mackessy SP (2021) 14 Sarafotoxins, the Snake Venom homologs of the endothelins. Handbook of venoms and toxins of reptiles. London, New York"},{"key":"1051_CR7","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2020.118459","volume":"261","author":"T Behl","year":"2020","unstructured":"Behl T, Chadha S, Sachdeva M, Kumar A, Hafeez A, Mehta V, Bungau S (2020) Ubiquitination in rheumatoid arthritis. Life Sci 261:118459. https:\/\/doi.org\/10.1016\/j.lfs.2020.118459","journal-title":"Life Sci"},{"key":"1051_CR8","first-page":"3","volume":"46","author":"G Bogdanov","year":"2015","unstructured":"Bogdanov G, Metodieva R, Boyadjieva N (2015) New research on endothelins and their receptors. S\u2019rdechno-S\u2019 Dovi Zabolyavaniya\/medical Review-Cardiovascular Diseases 46:3\u20138","journal-title":"S'rdechno-S' Dovi Zabolyavaniya\/medical Review-Cardiovascular Diseases"},{"key":"1051_CR9","doi-asserted-by":"publisher","first-page":"R1288","DOI":"10.1152\/ajpregu.00397.2010","volume":"300","author":"SL Bourque","year":"2011","unstructured":"Bourque SL, Davidge ST, Adams MA (2011) The interaction between endothelin-1 and nitric oxide in the vasculature: new perspectives. Am J Physiol Regul Integr Comp Physiol 300:R1288\u2013R1295. https:\/\/doi.org\/10.1152\/ajpregu.00397.2010","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"1051_CR10","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1016\/j.retram.2020.05.002","volume":"68","author":"S Chadha","year":"2020","unstructured":"Chadha S, Behl T, Kumar A, Khullar G, Arora S (2020) Role of Nrf2 in rheumatoid arthritis. Curr Res Transl Med 68:171\u2013181. https:\/\/doi.org\/10.1016\/j.retram.2020.05.002","journal-title":"Curr Res Transl Med"},{"key":"1051_CR11","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s10753-020-01324-8","volume":"44","author":"S Chadha","year":"2021","unstructured":"Chadha S, Behl T, Bungau S, Kumar A, Kaur R, Venkatachalam T, Gupta A, Kandhwal M, Chandel D (2021) Focus on the multimodal role of autophagy in rheumatoid arthritis. Inflammation 44:1\u20132. https:\/\/doi.org\/10.1007\/s10753-020-01324-8","journal-title":"Inflammation"},{"key":"1051_CR12","doi-asserted-by":"publisher","first-page":"1119","DOI":"10.1016\/S0140-6736(01)06250-X","volume":"358","author":"RN Channick","year":"2001","unstructured":"Channick RN, Simonneau G, Sitbon O, Robbins IM, Frost A, Tapson VF, Badesch DB, Roux S, Rainisio M, Bodin F, Rubin LJ (2001) Effects of the dual endothelin-receptor antagonist bosentan in patients with pulmonary hypertension: a randomised placebocontrolled study. Lancet 358:1119\u20131123. https:\/\/doi.org\/10.1016\/S0140-6736(01)06250-X","journal-title":"Lancet"},{"key":"1051_CR13","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.641874","author":"Z Chen","year":"2021","unstructured":"Chen Z, Zhang X, Lv S, Xing Z, Shi M, Li X, Chen M, Zuo S, Tao Y, Xiao G, Liu J, He Y (2021) Treatment with endothelin-A receptor antagonist BQ123 attenuates acute inflammation in mice through T cell-dependent polymorphonuclear myeloid-derived suppressor cell activation. Front Immunol. https:\/\/doi.org\/10.3389\/fimmu.2021.641874 (PMID: 33828553; PMCID: PMC8019801)","journal-title":"Front Immunol"},{"key":"1051_CR14","doi-asserted-by":"publisher","first-page":"29","DOI":"10.5339\/gcsp.2014.29","volume":"2014","author":"AH Chester","year":"2014","unstructured":"Chester AH, Yacoub MH (2014) The role of endothelin-1 in pulmonary arterial hypertension. Glob Cardiol Sci Pract 2014:29. https:\/\/doi.org\/10.5339\/gcsp.2014.29","journal-title":"Glob Cardiol Sci Pract"},{"key":"1051_CR15","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1007\/s00011-016-1001-7","volume":"66","author":"RF Claudino","year":"2017","unstructured":"Claudino RF, Leite DF, Bento AF, Chichorro JG, Calixto JB, Rae GA (2017) Potential role for ET-2 acting through ETA receptors in experimental colitis in mice. Inflamm Res 66:141\u2013155. https:\/\/doi.org\/10.1007\/s00011-016-1001-7","journal-title":"Inflamm Res"},{"key":"1051_CR16","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1080\/07853890410018925","volume":"37","author":"M Clozel","year":"2005","unstructured":"Clozel M, Salloukh H (2005) Role of endothelin in fibrosis and anti-fibrotic potential of bosentan. Ann Med 37:2\u201312. https:\/\/doi.org\/10.1080\/07853890410018925","journal-title":"Ann Med"},{"key":"1051_CR17","doi-asserted-by":"publisher","first-page":"652","DOI":"10.1189\/jlb.1207827","volume":"84","author":"FD Conte","year":"2008","unstructured":"Conte FD, Barja-Fidalgo C, Verri WA Jr, Cunha FQ, Rae GA, Penido C, Henriques MD (2008) Endothelins modulate inflammatory reaction in zymosan-induced arthritis: participation of LTB4, TNF-\u03b1, and CXCL-1. J Leukoc Biol 84:652\u2013660. https:\/\/doi.org\/10.1189\/jlb.1207827","journal-title":"J Leukoc Biol"},{"key":"1051_CR18","doi-asserted-by":"publisher","first-page":"911","DOI":"10.1111\/j.1476-5381.2010.00950.x","volume":"161","author":"FP Conte","year":"2010","unstructured":"Conte FP, Menezes-de-Lima O Jr, Verri WA Jr, Cunha FQ, Penido C, Henriques MG (2010) Lipoxin A4 attenuates zymosan-induced arthritis by modulating endothelin-1 and its effects. Br J Pharm 161:911\u2013924. https:\/\/doi.org\/10.1111\/j.1476-5381.2010.00950.x","journal-title":"Br J Pharm"},{"key":"1051_CR19","doi-asserted-by":"publisher","first-page":"1173","DOI":"10.1089\/jmf.2010.0272","volume":"10","author":"T Coppa","year":"2011","unstructured":"Coppa T, Lazz\u00e8 MC, Cazzalini O, Perucca P, Pizzala R, Bianchi L, Stivala LA, Forti L, Maccario C, Vannini V, Savio M (2011) Structure-activity relationship of resveratrol and its analogue, 4,4\u2019-dihydroxy-trans-stilbene, toward the endothelin axis in human endothelial cells. J Med Food 10:1173\u20131180. https:\/\/doi.org\/10.1089\/jmf.2010.0272 (Epub 2011 May 9 PMID: 21554123)","journal-title":"J Med Food"},{"key":"1051_CR20","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1124\/pr.115.011833","volume":"68","author":"AP Davenport","year":"2016","unstructured":"Davenport AP, Hyndman KA, Dhaun N, Southan C, Kohan DE, Pollock JS, Pollock DM, Webb DJ, Maguire JJ (2016) Endothelin. Pharm Rev 68:357\u2013418. https:\/\/doi.org\/10.1124\/pr.115.011833","journal-title":"Pharm Rev"},{"key":"1051_CR21","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1016\/j.brainres.2011.04.028","volume":"1395","author":"R Del Rio","year":"2011","unstructured":"Del Rio R, Moya EA, Iturriaga R (2011) Differential expression of pro-inflammatory cytokines, endothelin-1 and nitric oxide synthases in the rat carotid body exposed to intermittent hypoxia. Brain Res 1395:74\u201385. https:\/\/doi.org\/10.1016\/j.brainres.2011.04.028","journal-title":"Brain Res"},{"key":"1051_CR22","doi-asserted-by":"publisher","first-page":"1212","DOI":"10.1053\/j.jvca.2013.01.023","volume":"27","author":"AY Denault","year":"2013","unstructured":"Denault AY, Pearl RG, Michler RE, Rao V, Tsui SS, Seitelberger R, Cromie M, Lindberg E, D\u2019Armini AM (2013) Tezosentan and right ventricular failure in patients with pulmonary hypertension undergoing cardiac surgery: the TACTICS trial. J Cardiothorac Vasc Anesth 27:1212\u20131217. https:\/\/doi.org\/10.1053\/j.jvca.2013.01.023","journal-title":"J Cardiothorac Vasc Anesth"},{"key":"1051_CR23","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1007\/s00011-011-0415-5","volume":"61","author":"PB Donate","year":"2012","unstructured":"Donate PB, Cunha TM, Verri WA, Junta CM, Lima FO, Vieira SM, Peres RS, Bombonato-Prado KF, Louzada P, Ferreira SH, Donadi EA (2012) Bosentan, an endothelin receptor antagonist, ameliorates collagen-induced arthritis: the role of TNF-\u03b1 in the induction of endothelin system genes. Inflamm Res 61:337\u2013348. https:\/\/doi.org\/10.1007\/s00011-011-0415-5","journal-title":"Inflamm Res"},{"key":"1051_CR24","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1016\/j.pharmthera.2018.10.001","volume":"194","author":"P D'Orl\u00e9ans-Juste","year":"2019","unstructured":"D\u2019Orl\u00e9ans-Juste P, Ndunge OB, Desbiens L, Tanowitz HB, Desruisseaux MS (2019) Endothelins in inflammatory neurological diseases. Pharmacol Ther 194:145\u2013160. https:\/\/doi.org\/10.1016\/j.pharmthera.2018.10.001","journal-title":"Pharmacol Ther"},{"key":"1051_CR25","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/147616","author":"T Elisa","year":"2015","unstructured":"Elisa T, Antonio P, Giuseppe P, Alessandro B, Giuseppe A, Federico C, Marzia D, Ruggero B, Giacomo M, Andrea O, Daniela R (2015) Endothelin receptors expressed by immune cells are involved in modulation of inflammation and in fibrosis: relevance to the pathogenesis of systemic sclerosis. J Immunol Res. https:\/\/doi.org\/10.1155\/2015\/147616","journal-title":"J Immunol Res"},{"key":"1051_CR26","doi-asserted-by":"publisher","first-page":"264","DOI":"10.1080\/1061186X.2016.1245308","volume":"25","author":"V Fattori","year":"2017","unstructured":"Fattori V, Serafim KG, Zarpelon AC, Borghi SM, Pinho-Ribeiro FA, Alves-Filho JC, Cunha TM, Cunha FQ, Casagrande R, Verri WA Jr (2017) Differential regulation of oxidative stress and cytokine production by endothelin ETA and ETB receptors in superoxide anion-induced inflammation and pain in mice. J Drug Target 25:264\u2013274. https:\/\/doi.org\/10.1080\/1061186X.2016.1245308","journal-title":"J Drug Target"},{"key":"1051_CR27","doi-asserted-by":"publisher","first-page":"645","DOI":"10.1080\/1061186X.2016.1245308","volume":"110","author":"M Felx","year":"2006","unstructured":"Felx M, Guyot MC, Isler M, Turcotte RE, Doyon J, Khatib AM, Leclerc S, Moreau A, Moldovan F (2006) Endothelin-1 (ET-1) promotes MMP-2 and MMP-9 induction involving the transcription factor NF-\u03baB in human osteosarcoma. Clin Sci 110:645\u2013654. https:\/\/doi.org\/10.1080\/1061186X.2016.1245308","journal-title":"Clin Sci"},{"key":"1051_CR28","doi-asserted-by":"publisher","first-page":"111","DOI":"10.3389\/fimmu.2020.00111","volume":"11","author":"TL Fernandes","year":"2020","unstructured":"Fernandes TL, Gomoll AH, Lattermann C, Hernandez AJ, Bueno DF, Amano MT (2020) Macrophage: a potential target on cartilage regeneration. Front Immunol 11:111. https:\/\/doi.org\/10.3389\/fimmu.2020.00111","journal-title":"Front Immunol"},{"key":"1051_CR29","doi-asserted-by":"publisher","first-page":"L659","DOI":"10.1152\/ajplung.2001.280.4.L659","volume":"280","author":"F Finsnes","year":"2001","unstructured":"Finsnes F, Lyberg T, Christensen G, Skj\u00f8nsberg OH (2001) Effect of endothelin antagonism on the production of cytokines in eosinophilic airway inflammation. Am J Physiol Lung Cell Mol Physiol 280:L659\u2013L665. https:\/\/doi.org\/10.1152\/ajplung.2001.280.4.L659","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"1051_CR30","doi-asserted-by":"publisher","first-page":"2130","DOI":"10.1093\/cvr\/27.12.2130","volume":"27","author":"E Guarda","year":"1993","unstructured":"Guarda E, Katwa LC, Myers PR, Tyagi SC, Weber KT (1993) Effects of endothelins on collagen turnover in cardiac fibroblasts. Cardiovasc Res 27:2130\u20132134. https:\/\/doi.org\/10.1093\/cvr\/27.12.2130","journal-title":"Cardiovasc Res"},{"key":"1051_CR31","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1016\/j.npep.2007.12.001","volume":"42","author":"G Hans","year":"2008","unstructured":"Hans G, Deseure K, Adriaensen H (2008) Endothelin-1-induced pain and hyperalgesia: a review of pathophysiology, clinical manifestations and future therapeutic options. Neuropeptides 42:119\u2013132. https:\/\/doi.org\/10.1016\/j.npep.2007.12.001","journal-title":"Neuropeptides"},{"key":"1051_CR32","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1016\/bs.apha.2016.05.002","volume":"77","author":"M Houde","year":"2016","unstructured":"Houde M, Desbiens L, D\u2019Orl\u00e9ans-Juste P (2016) Endothelin-1: biosynthesis, signaling and vasoreactivity. Adv Pharmacol 77:143\u2013175. https:\/\/doi.org\/10.1016\/bs.apha.2016.05.002","journal-title":"Adv Pharmacol"},{"key":"1051_CR33","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1038\/ki.1996.25","volume":"49","author":"AK Hughes","year":"1996","unstructured":"Hughes AK, Stricklett PK, Padilla E, Kohan DE (1996) Effect of reactive oxygen species on endothelin-1 production by human mesangial l cells. Kidney Int 49:181\u2013189. https:\/\/doi.org\/10.1038\/ki.1996.25","journal-title":"Kidney Int"},{"key":"1051_CR34","doi-asserted-by":"publisher","DOI":"10.1186\/ar3372","author":"AK Imhof","year":"2011","unstructured":"Imhof AK, Gl\u00fcck L, Gajda M, Br\u00e4uer R, Schaible HG, Schulz S (2011) Potent anti-inflammatory and antinociceptive activity of the endothelin receptor antagonist bosentan in monoarthritic mice. Arthritis Res Ther. https:\/\/doi.org\/10.1186\/ar3372 (PMID: 21689431; PMCID: PMC3218912)","journal-title":"Arthritis Res Ther"},{"key":"1051_CR35","doi-asserted-by":"crossref","unstructured":"Jarvis MF, Wessale JL, Zhu CZ, Lynch J. (2000) ABT-627 An endothelin ETA receptor selective antagonist, attenuates tactile allodynia in a diabetic rat model of neuropathic pain. Eur J Pharmacol. https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S0014299999008651","DOI":"10.1016\/S0014-2999(99)00865-1"},{"key":"1051_CR36","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1684\/ecn.2015.0360","volume":"26","author":"J Jing","year":"2015","unstructured":"Jing J, Dou TT, Yang JQ, Chen XB, Cao HL, Min M, Cai SQ, Zheng M, Man XY (2015) Role of endothelin-1 in the skin fibrosis of systemic sclerosis. Eur Cytokine Netw 26:10\u201314. https:\/\/doi.org\/10.1684\/ecn.2015.0360","journal-title":"Eur Cytokine Netw"},{"key":"1051_CR37","doi-asserted-by":"publisher","first-page":"1695","DOI":"10.1007\/s00296-009-1285-9","volume":"30","author":"JB Jun","year":"2010","unstructured":"Jun JB, Na YI, Kim TH et al (2010) Dietary flavonoid apigenin inhibits endothelin-1-induced contraction of collagen gel. Rheumatol Int 30:1695\u20131697. https:\/\/doi.org\/10.1007\/s00296-009-1285-9","journal-title":"Rheumatol Int"},{"issue":"1","key":"1051_CR38","doi-asserted-by":"publisher","first-page":"15931","DOI":"10.1038\/s41598-020-72960-1","volume":"10","author":"L Kappes","year":"2020","unstructured":"Kappes L, Amer RL, Sommerlatte S, Bashir G, Plattfaut C, Gieseler F, Gemoll T, Busch H, Altahrawi A, Al-Sbiei A, Haneefa SM, Arafat K, Schimke LF, Khawanky NE, Schulze-Forster K, Heidecke H, Kerstein-Staehle A, Marschner G, Pitann S, Ochs HD, Mueller A, Attoub S, Fernandez-Cabezudo MJ, Riemekasten G, Al-Ramadi BK, Cabral-Marques O (2020) Ambrisentan, an endothelin receptor type a-selective antagonist, inhibits cancer cell migration, invasion, and metastasis. Sci Rep 10(1):15931. https:\/\/doi.org\/10.1038\/s41598-020-72960-1","journal-title":"Sci Rep"},{"key":"1051_CR39","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2020.118164","volume":"258","author":"I Kaur","year":"2020","unstructured":"Kaur I, Behl T, Bungau S, Kumar A, Mehta V, Setia D, Uddin MS, Zengin G, Aleya L, Arora S (2020) Exploring the therapeutic promise of targeting HMGB1 in rheumatoid arthritis. Life Sci 258:118164. https:\/\/doi.org\/10.1016\/j.lfs.2020.118164","journal-title":"Life Sci"},{"key":"1051_CR40","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1007\/s00018-010-0518-0","volume":"68","author":"Y Kawanabe","year":"2011","unstructured":"Kawanabe Y, Nauli SM (2011) Endothelin. Cell Mol Life Sci 68:195\u2013203. https:\/\/doi.org\/10.1007\/s00018-010-0518-0","journal-title":"Cell Mol Life Sci"},{"key":"1051_CR41","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1007\/s00005-014-0310-1","volume":"63","author":"A Kowalczyk","year":"2015","unstructured":"Kowalczyk A, Kleniewska P, Kolodziejczyk M, Skibska B, Goraca A (2015) The role of endothelin-1 and endothelin receptor antagonists in inflammatory response and sepsis. Arch Immunol Ther Exp 63:41\u201352. https:\/\/doi.org\/10.1007\/s00005-014-0310-1","journal-title":"Arch Immunol Ther Exp"},{"issue":"8","key":"1051_CR42","doi-asserted-by":"publisher","first-page":"1613","DOI":"10.1271\/bbb.69.1613","volume":"69","author":"T Kozakai","year":"2005","unstructured":"Kozakai T, Yamanaka A, Ichiba T, Toyokawa T, Kamada Y, Tamamura T, Ichimura T (2005) Luteolin inhibits endothelin-1 secretion in cultured endothelial cells. Biosci Biotechnol Biochem 69(8):1613\u20131615. https:\/\/doi.org\/10.1271\/bbb.69.1613","journal-title":"Biosci Biotechnol Biochem"},{"key":"1051_CR43","doi-asserted-by":"publisher","first-page":"314","DOI":"10.1007\/s10067-005-0007-2","volume":"25","author":"A Kuryliszyn-Moskal","year":"2006","unstructured":"Kuryliszyn-Moskal A, Klimiuk PA, Sierakowski S, Ciolkiewicz M (2006) A study on vascular endothelial growth factor and endothelin-1 in patients with extra-articular involvement of rheumatoid arthritis. Clin Rheumatol 25:314\u2013319. https:\/\/doi.org\/10.1007\/s10067-005-0007-2","journal-title":"Clin Rheumatol"},{"key":"1051_CR44","doi-asserted-by":"publisher","first-page":"1042","DOI":"10.1111\/j.1600-6143.2005.00807.x","volume":"5","author":"T Lattmann","year":"2005","unstructured":"Lattmann T, Hein M, Horber S, Ortmann J, Teixeira MM, Souza DG, Haas E, Tornillo L, M\u00fcnter K, Vetter W, Barton M (2005) Activation of pro-inflammatory and anti-inflammatory cytokines in host organs during chronic allograft rejection: role of endothelin receptor signaling. Am J Transpl 5:1042\u20131049. https:\/\/doi.org\/10.1111\/j.1600-6143.2005.00807.x","journal-title":"Am J Transpl"},{"key":"1051_CR45","doi-asserted-by":"publisher","first-page":"1675","DOI":"10.1161\/CIRCRESAHA.110.217737","volume":"106","author":"A Leask","year":"2010","unstructured":"Leask A (2010) Potential therapeutic targets for cardiac fibrosis: TGF\u03b2, angiotensin, endothelin, CCN2, and PDGF, partners in fibroblast activation. Circ Res 106:1675\u20131680. https:\/\/doi.org\/10.1161\/CIRCRESAHA.110.217737","journal-title":"Circ Res"},{"key":"1051_CR47","doi-asserted-by":"publisher","first-page":"618","DOI":"10.1902\/jop.2013.130195","volume":"85","author":"L Liang","year":"2014","unstructured":"Liang L, Yu J, Zhou W, Liu N, L E, Wang DS, Liu H (2014) Endothelin-1 stimulates proinflammatory cytokine expression in human periodontal ligament cells via mitogen-activated protein kinase pathway. J Periodontol 85:618\u2013626. https:\/\/doi.org\/10.1902\/jop.2013.130195","journal-title":"J Periodontol"},{"key":"1051_CR48","doi-asserted-by":"crossref","unstructured":"Liu K, Zhao W, Gao X, Huang F. (2012) Diosgenin ameliorates palmitate-induced endothelial dysfunction and insulin resistance via blocking IKK\u03b2 and IRS-1 pathways. Atherosclerosis. 2012 August. https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S0021915012003875","DOI":"10.1016\/j.atherosclerosis.2012.06.012"},{"key":"1051_CR49","doi-asserted-by":"publisher","first-page":"1058","DOI":"10.1124\/jpet.105.091728","volume":"315","author":"ED Loomis","year":"2005","unstructured":"Loomis ED, Sullivan JC, Osmond DA, Pollock DM, Pollock JS (2005) Endothelin mediates superoxide production and vasoconstriction through activation of NADPH oxidase and uncoupled nitric-oxide synthase in the rat aorta. J Pharmacol 315:1058\u20131064. https:\/\/doi.org\/10.1124\/jpet.105.091728","journal-title":"J Pharmacol"},{"key":"1051_CR50","doi-asserted-by":"publisher","first-page":"434","DOI":"10.1136\/ard.2008.105692","volume":"69","author":"E Lozano","year":"2010","unstructured":"Lozano E, Segarra M, Corbera-Bellalta M, Garc\u00eda-Mart\u00ednez A, Esp\u00edgol-Frigol\u00e9 G, Pl\u00e0-Campo A, Hern\u00e1ndez-Rodr\u00edguez J, Cid MC (2010) Increased expression of the endothelin system in arterial lesions from patients with giant-cell arteritis: association between elevated plasma endothelin levels and the development of ischaemic events. Ann Rheum Dis 69:434\u2013442. https:\/\/doi.org\/10.1136\/ard.2008.105692","journal-title":"Ann Rheum Dis"},{"issue":"4","key":"1051_CR51","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0153015","volume":"11","author":"MF Manchope","year":"2016","unstructured":"Manchope MF, Calixto-Campos C, Coelho-Silva L, Zarpelon AC, Pinho-Ribeiro FA, Georgetti SR, Baracat MM, Casagrande R, Verri WA Jr (2016) Naringenin inhibits superoxide anion-induced inflammatory pain: role of oxidative stress, cytokines, Nrf-2 and the NO-cGMP-PKG-KATP channel signaling pathway. PLoS One 11(4):e0153015. https:\/\/doi.org\/10.1371\/journal.pone.0153015","journal-title":"PLoS One"},{"key":"1051_CR52","doi-asserted-by":"publisher","first-page":"80","DOI":"10.4103\/2152-7806.73804","volume":"1","author":"JC Maroon","year":"2010","unstructured":"Maroon JC, Bost JW, Maroon A (2010) Natural anti-inflammatory agents for pain relief. Surg Neurol Int 1:80. https:\/\/doi.org\/10.4103\/2152-7806.73804","journal-title":"Surg Neurol Int"},{"key":"1051_CR53","doi-asserted-by":"publisher","first-page":"2205","DOI":"10.1056\/NEJMra1004965","volume":"365","author":"IB McInnes","year":"2011","unstructured":"McInnes IB, Schett G (2011) The pathogenesis of rheumatoid arthritis. N Engl J Med 365:2205\u20132219. https:\/\/doi.org\/10.1056\/NEJMra1004965","journal-title":"N Engl J Med"},{"key":"1051_CR54","doi-asserted-by":"publisher","first-page":"386","DOI":"10.1016\/j.pharmthera.2005.08.012","volume":"110","author":"S Motte","year":"2006","unstructured":"Motte S, McEntee K, Naeije R (2006) Endothelin receptor antagonists. Pharm Ther 110:386\u2013414. https:\/\/doi.org\/10.1016\/j.pharmthera.2005.08.012","journal-title":"Pharm Ther"},{"key":"1051_CR55","doi-asserted-by":"publisher","first-page":"4624","DOI":"10.2174\/1381612826666200413082353","volume":"26","author":"K Mourouzis","year":"2020","unstructured":"Mourouzis K, Oikonomou E, Siasos G, Tsalamadris S, Vogiatzi G, Antonopoulos A, Fountoulakis P, Goliopoulou A, Papaioannou S, Tousoulis D (2020) Pro-inflammatory cytokines in acute coronary syndromes. Curr Pharm Des 26:4624\u20134647. https:\/\/doi.org\/10.2174\/1381612826666200413082353","journal-title":"Curr Pharm Des"},{"key":"1051_CR56","doi-asserted-by":"publisher","first-page":"282","DOI":"10.1161\/01.HYP.36.2.282","volume":"36","author":"DN Muller","year":"2000","unstructured":"Muller DN, Mervaala EM, Schmidt F, Park JK, Dechend R, Genersch E, Breu V, L\u00f6ffler BM, Ganten D, Schneider W, Haller H (2000) Effect of bosentan on NF-\u03baB, inflammation, and tissue factor in angiotensin II\u2013induced end-organ damage. Hypertension 36:282\u2013290. https:\/\/doi.org\/10.1161\/01.HYP.36.2.282","journal-title":"Hypertension"},{"key":"1051_CR57","doi-asserted-by":"publisher","first-page":"330","DOI":"10.1111\/j.1365-2222.1994.tb00243.x","volume":"24","author":"J Nakano","year":"1994","unstructured":"Nakano J, Takizawa H, Ohtoshi T, Shoji S, Yamaguchi M, Ishii A, Yanagisawa M, Ito K (1994) Endotoxin and pro-inflammatory cytokines stimulate endothelin-I expression and release by airway epithelial cells. Clin Exp Allergy 24:330\u2013336. https:\/\/doi.org\/10.1111\/j.1365-2222.1994.tb00243.x","journal-title":"Clin Exp Allergy"},{"key":"1051_CR58","doi-asserted-by":"publisher","first-page":"535","DOI":"10.1080\/1744666X.2017.1295850","volume":"13","author":"M Narazaki","year":"2017","unstructured":"Narazaki M, Tanaka T, Kishimoto T (2017) The role and therapeutic targeting of IL-6 in rheumatoid arthritis. Expert Rev Clin Immunol 13:535\u2013551. https:\/\/doi.org\/10.1080\/1744666X.2017.1295850","journal-title":"Expert Rev Clin Immunol"},{"key":"1051_CR59","doi-asserted-by":"publisher","first-page":"326","DOI":"10.1016\/B978-0-12-801028-0.00036-2","volume-title":"In handbook of hormones","author":"HE Ohtaki","year":"2016","unstructured":"Ohtaki HE (2016) In handbook of hormones. Academic Press, Cambrige, pp 326-e36"},{"key":"1051_CR60","doi-asserted-by":"publisher","first-page":"872","DOI":"10.5604\/17322693.1214386","volume":"70","author":"J Olender","year":"2016","unstructured":"Olender J, Nowakowska-Zajdel E, Walkiewicz K, Muc-Wierzgo\u0144 M (2016) Endothelins and carcinogenesis. Postepy Hig Med Dosw 70:872\u2013880. https:\/\/doi.org\/10.5604\/17322693.1214386","journal-title":"Postepy Hig Med Dosw"},{"key":"1051_CR61","first-page":"94","volume":"23","author":"A Parida","year":"2013","unstructured":"Parida A, Nayak V (2013) Endothelins: Their current status and future prospects. Int J Pharm Sci Rev Res 23:94\u201397","journal-title":"Int J Pharm Sci Rev Res"},{"key":"1051_CR62","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1016\/j.peptides.2007.11.015","volume":"29","author":"H Peng","year":"2008","unstructured":"Peng H, Chen P, Cai Y, Chen Y, Wu QH, Li Y, Zhou R, Fang X (2008) Endothelin-1 increases expression of cyclooxygenase-2 and production of interlukin-8 in hunan pulmonary epithelial cells. Peptides 29:419\u2013424. https:\/\/doi.org\/10.1016\/j.peptides.2007.11.015","journal-title":"Peptides"},{"key":"1051_CR63","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1016\/j.cbi.2017.12.024","volume":"281","author":"AR Phull","year":"2018","unstructured":"Phull AR, Nasir B, ul Haq I, Kim SJ (2018) Oxidative stress, consequences and ROS mediated cellular signaling in rheumatoid arthritis. Chem Biol Interact 281:121\u2013136. https:\/\/doi.org\/10.1016\/j.cbi.2017.12.024","journal-title":"Chem Biol Interact"},{"key":"1051_CR64","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1097\/MNH.0b013e32834f0092","volume":"21","author":"Y Rautureau","year":"2012","unstructured":"Rautureau Y, Schiffrin EL (2012) Endothelin in hypertension: an update. Curr Opin Nephrol Hypertens 21:128\u2013136. https:\/\/doi.org\/10.1097\/MNH.0b013e32834f0092","journal-title":"Curr Opin Nephrol Hypertens"},{"key":"1051_CR65","doi-asserted-by":"publisher","first-page":"322","DOI":"10.1016\/S1091-255X(01)80055-X","volume":"5","author":"R Ricciardi","year":"2001","unstructured":"Ricciardi R, Schafer BK, Shah SA, Quarfordt SH, Banner BF, Wheeler SM, Donahue SE, Meyers WC, Chari RS (2001) Bosentan, an endothelin antagonist, augments hepatic graft function by reducing graft circulatory impairment following ischemia\/reperfusion injury. J Gastrointest Surg 5:322\u2013329. https:\/\/doi.org\/10.1016\/S1091-255X(01)80055-X","journal-title":"J Gastrointest Surg"},{"key":"1051_CR66","doi-asserted-by":"crossref","unstructured":"Sah SK, Kin B, Park GT, Kim S (2013) Novel isonahocol E3 exhibits anti-inflammatory and anti-angiogenic effects in endothelin-1-stimulated human keratinocytes. Eur J Pharm. https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S0014299913007838","DOI":"10.1016\/j.ejphar.2013.09.077"},{"key":"1051_CR67","doi-asserted-by":"publisher","first-page":"5682","DOI":"10.1111\/bph.12870","volume":"171","author":"A S\u00e1nchez","year":"2014","unstructured":"S\u00e1nchez A, Mart\u00ednez P, Mu\u00f1oz M, Benedito S, Garc\u00eda-Sacrist\u00e1n A, Hern\u00e1ndez M, Prieto D (2014) Endothelin-1 contributes to endothelial dysfunction and enhanced vasoconstriction through augmented superoxide production in penile arteries from insulin-resistant obese rats: role of ETA and ETB receptors. Br J Pharm 171:5682\u20135695. https:\/\/doi.org\/10.1111\/bph.12870","journal-title":"Br J Pharm"},{"key":"1051_CR68","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2013.09.025","author":"A Sato","year":"2013","unstructured":"Sato A, Ebina K (2013) Common mechanism in endothelin-3 and PAF receptor function for anti-inflammatory responses. Eur J Pharm. https:\/\/doi.org\/10.1016\/j.ejphar.2013.09.025 (Epub. PMID: 24055926)","journal-title":"Eur J Pharm"},{"key":"1051_CR69","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41598-017-14202-5","volume":"7","author":"S Shinagawa","year":"2017","unstructured":"Shinagawa S, Okazaki T, Ikeda M, Yudoh K, Kisanuki YY, Yanagisawa M, Kawahata K, Ozaki S (2017) T cells upon activation promote endothelin 1 production in monocytes via IFN-\u03b3 and TNF-\u03b1. Sci Rep 7:1\u20138. https:\/\/doi.org\/10.1038\/s41598-017-14202-5","journal-title":"Sci Rep"},{"key":"1051_CR70","doi-asserted-by":"publisher","first-page":"702","DOI":"10.1016\/j.jpain.2008.12.005","volume":"10","author":"S Shrestha","year":"2009","unstructured":"Shrestha S, Gracias NG, Mujenda F, Khodorova A, Vasko MR, Strichartz GR (2009) Local antinociception induced by endothelin-1 in the hairy skin of the rat\u2019s back. J Pain 10:702\u2013714. https:\/\/doi.org\/10.1016\/j.jpain.2008.12.005","journal-title":"J Pain"},{"key":"1051_CR71","doi-asserted-by":"publisher","first-page":"516","DOI":"10.1016\/j.joca.2014.11.002","volume":"23","author":"A Sin","year":"2015","unstructured":"Sin A, Tang W, Wen CY, Chung SK, Chiu KY (2015) The emerging role of endothelin-1 in the pathogenesis of subchondral bone disturbance and osteoarthritis. Osteoarthr Cartil 23:516\u2013524. https:\/\/doi.org\/10.1016\/j.joca.2014.11.002","journal-title":"Osteoarthr Cartil"},{"key":"1051_CR72","doi-asserted-by":"publisher","first-page":"1111","DOI":"10.1136\/annrheumdis-2017-eular.5857","volume":"76","author":"S Soldano","year":"2017","unstructured":"Soldano S, Montagna P, Brizzolara R, Trombetta AC, Corallo C, Pizzorni C, Paolino S, Sulli A, Ghio M, Smith V, Giordano N (2017) AB0185 Endothelin-1 stimulates the profibrotic alternative activated phenotype in cultured human macrophages isolated from systemic sclerosis patients. Ann Rheum Dis 76:1111\u20131111. https:\/\/doi.org\/10.1136\/annrheumdis-2017-eular.5857","journal-title":"Ann Rheum Dis"},{"key":"1051_CR73","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1016\/S0021-9150(02)00013-8","volume":"163","author":"F Squadrito","year":"2002","unstructured":"Squadrito F, Altavilla D, Morabito N, Crisafulli A, D\u2019Anna R, Corrado F, Ruggeri P, Campo GM, Calapai G, Caputi AP, Squadrito G (2002) The effect of the phytoestrogen genistein on plasma nitric oxide concentrations, endothelin-1 levels and endothelium dependent vasodilation in postmenopausal women. Atherosclerosis 163:339\u2013347. https:\/\/doi.org\/10.1016\/S0021-9150(02)00013-8","journal-title":"Atherosclerosis"},{"key":"1051_CR74","doi-asserted-by":"publisher","DOI":"10.1080\/1028415X.2015.1119377","author":"DL Stankowska","year":"2017","unstructured":"Stankowska DL, Krishnamoorthy VR, Ellis DZ, Krishnamoorthy RR (2017) Neuroprotective effects of curcumin on endothelin-1 mediated cell death in hippocampal neurons. Nutr Neurosci. https:\/\/doi.org\/10.1080\/1028415X.2015.1119377 (Epub 2015 Dec 12. PMID: 26651837)","journal-title":"Nutr Neurosci"},{"key":"1051_CR75","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1096\/fj.10-161612","volume":"25","author":"LR Stow","year":"2011","unstructured":"Stow LR, Jacobs ME, Wingo CS, Cain BD (2011) Endothelin-1 gene regulation. FASEB J 25:16\u201328. https:\/\/doi.org\/10.1096\/fj.10-161612","journal-title":"FASEB J"},{"key":"1051_CR76","doi-asserted-by":"publisher","first-page":"266","DOI":"10.4193\/Rhino15.059","volume":"54","author":"A Tatar","year":"2016","unstructured":"Tatar A, Yayla M, Kose D, Halici Z, Yoruk O, Polat E (2016) The role of endothelin-1 and endothelin receptor antagonists in allergic rhinitis inflammation: ovalbumin-induced rat model. Rhinology 54:266\u2013272. https:\/\/doi.org\/10.4193\/Rhino15.059","journal-title":"Rhinology"},{"key":"1051_CR77","first-page":"876","volume":"32","author":"EV Tchetina","year":"2005","unstructured":"Tchetina EV, Squires G, Poole AR (2005) Increased type II collagen degradation and very early focal cartilage degeneration is associated with upregulation of chondrocyte differentiation related genes in early human articular cartilage lesions. J Rheumatol 32:876\u2013886","journal-title":"J Rheumatol"},{"key":"1051_CR78","doi-asserted-by":"publisher","first-page":"3490","DOI":"10.1167\/iovs.11-9415","volume":"53","author":"M Tonari","year":"2012","unstructured":"Tonari M, Kurimoto T, Horie T et al (2012) Blocking endothelin-B receptors rescues retinal ganglion cells from optic nerve injury through suppression of neuroinflammation. Invest Ophthalmol vis Sci 53:3490\u20133500","journal-title":"Invest Ophthalmol vis Sci"},{"issue":"8","key":"1051_CR79","doi-asserted-by":"publisher","first-page":"1613","DOI":"10.1271\/bbb.69.1613","volume":"69","author":"W Urbanowicz","year":"2005","unstructured":"Urbanowicz W, Sogni P, Moreau R (2005) Tezosentan, an endothelin receptor antagonist, limits liver injury in endotoxin challenged cirrhotic rats. Biosci Biotechnol Biochem 69(8):1613\u20131615. https:\/\/doi.org\/10.1271\/bbb.69.1613","journal-title":"Biosci Biotechnol Biochem"},{"key":"1051_CR80","doi-asserted-by":"publisher","first-page":"322","DOI":"10.1124\/jpet.116.234930","volume":"361","author":"M Vercauteren","year":"2017","unstructured":"Vercauteren M, Trensz F, Pasquali A, Cattaneo C, Strasser DS, Hess P, Iglarz M, Clozel M (2017) Endothelin ETA receptor blockade, by activating ETB receptors, increases vascular permeability and induces exaggerated fluid retention. J Pharm Exp Ther 361:322\u2013333. https:\/\/doi.org\/10.1124\/jpet.116.234930","journal-title":"J Pharm Exp Ther"},{"key":"1051_CR81","doi-asserted-by":"publisher","first-page":"519","DOI":"10.1016\/j.phrs.2011.01.002","volume":"63","author":"R Wang","year":"2011","unstructured":"Wang R, Dashwood RH (2011) Endothelins and their receptors in cancer: identification of therapeutic targets. Pharm Res 63:519\u2013524. https:\/\/doi.org\/10.1016\/j.phrs.2011.01.002","journal-title":"Pharm Res"},{"key":"1051_CR82","doi-asserted-by":"publisher","unstructured":"Wenzel RR, Littke T, Kuranoff S, J\u00fcrgens C, Bruck H, Ritz E, Philipp T, Mitchell A. (2009) SPP301 (Avosentan) endothelin antagonist Evaluation in Diabetic Nephropathy Study Investigators. Avosentan reduces albumin excretion in diabetics with macroalbuminuria. J Am Soc Nephrol 20(3):655\u201364 https:\/\/doi.org\/10.1681\/ASN.2008050482Epub 2009 Jan 14. PMID: 19144760; PMCID: PMC2653691","DOI":"10.1681\/ASN.2008050482"},{"key":"1051_CR83","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0161988","volume":"11","author":"PJ Wermuth","year":"2016","unstructured":"Wermuth PJ, Li Z, Mendoza FA, Jimenez SA (2016) Stimulation of transforming growth factor-\u03b21-induced endothelial-to-mesenchymal transition and tissue fibrosis by endothelin-1 (ET-1): a novel profibrotic effect of ET-1. PLoS One 11:e0161988. https:\/\/doi.org\/10.1371\/journal.pone.0161988","journal-title":"PLoS One"},{"key":"1051_CR84","doi-asserted-by":"publisher","first-page":"5620","DOI":"10.1002\/anie.201200984","volume":"51","author":"CT Wong","year":"2012","unstructured":"Wong CT, Rowlands DK, Wong CH, Lo TW, Nguyen GK, Li HY, Tam JP (2012) Orally active peptidic bradykinin B1 receptor antagonists engineered from a cyclotide scaffold for inflammatory pain treatment. Angew Chem Int Ed 51:5620\u20135624. https:\/\/doi.org\/10.1002\/anie.201200984","journal-title":"Angew Chem Int Ed"},{"key":"1051_CR85","doi-asserted-by":"publisher","first-page":"290","DOI":"10.1177\/000456329803500215","volume":"35","author":"H Yoshida","year":"1998","unstructured":"Yoshida H, Imafuku Y, Ohhara M, Miyata M, Kasukawa R, Ohsumi K, Horiuchi J (1998) Endothelin-1 production by human synoviocytes. Ann Clin Biochem 35:290\u2013294. https:\/\/doi.org\/10.1177\/000456329803500215","journal-title":"Ann Clin Biochem"},{"key":"1051_CR86","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1080\/0886022X.2021.1871921","volume":"43","author":"J Yu","year":"2021","unstructured":"Yu J, Chen X, Li Y, Wang Y, Cao X, Liu Z, Shen B, Zou J, Ding X (2021) Pro-inflammatory cytokines as potential predictors for intradialytic hypotension. Ren Fail 43:198\u2013205. https:\/\/doi.org\/10.1080\/0886022X.2021.1871921","journal-title":"Ren Fail"},{"key":"1051_CR87","unstructured":"Yuzugulen J. (2016) Characterisation of proendothelin-1 derived peptides and evaluation of their utility as biomarkers of vascular and renal pathologies (Doctoral dissertation, Queen Mary University of London)"},{"key":"1051_CR88","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1111\/bph.12110","volume":"169","author":"AC Zarpelon","year":"2013","unstructured":"Zarpelon AC, Cunha TM, Alves-Filho JC, Pinto LG, Ferreira SH, McInnes IB, Xu D, Liew FY, Cunha FQ, Verri WA Jr (2013) IL-33\/ST 2 signalling contributes to carrageenin-induced innate inflammation and inflammatory pain: role of cytokines, endothelin-1 and prostaglandin E 2. Br J Pharm 169:90\u2013101. https:\/\/doi.org\/10.1111\/bph.12110","journal-title":"Br J Pharm"},{"key":"1051_CR89","doi-asserted-by":"publisher","first-page":"1040","DOI":"10.1016\/j.yexcr.2010.12.026","volume":"317","author":"S Zhan","year":"2011","unstructured":"Zhan S, Rockey DC (2011) Tumor necrosis factor \u03b1 stimulates endothelin-1 synthesis in rat hepatic stellate cells in hepatic wound healing through a novel IKK\/JNK pathway. Exp Cell Res 317:1040\u20131048. https:\/\/doi.org\/10.1016\/j.yexcr.2010.12.026","journal-title":"Exp Cell Res"},{"key":"1051_CR90","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.00176","author":"S Zhang","year":"2019","unstructured":"Zhang S, Lin X (2019) CARMA3: Scaffold protein involved in NF-\u03baB signaling. Front Immunol. https:\/\/doi.org\/10.3389\/fimmu.2019.00176","journal-title":"Front Immunol"},{"key":"1051_CR91","doi-asserted-by":"publisher","first-page":"872","DOI":"10.1002\/jcla.22094","volume":"64","author":"Z Zhao","year":"2016","unstructured":"Zhao Z, Li E, Cao Q, Sun J, Ma B (2016) Endothelin-1 concentrations are correlated with the severity of knee osteoarthritis. J Investig Med 64:872\u2013874. https:\/\/doi.org\/10.1002\/jcla.22094","journal-title":"J Investig Med"}],"container-title":["Inflammopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10787-022-01051-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10787-022-01051-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10787-022-01051-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,9,22]],"date-time":"2022-09-22T11:33:12Z","timestamp":1663846392000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10787-022-01051-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8,27]]},"references-count":90,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2022,10]]}},"alternative-id":["1051"],"URL":"https:\/\/doi.org\/10.1007\/s10787-022-01051-6","relation":{},"ISSN":["0925-4692","1568-5608"],"issn-type":[{"value":"0925-4692","type":"print"},{"value":"1568-5608","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,8,27]]},"assertion":[{"value":"11 March 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 July 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 August 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"None.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"All authors have given consent for publication of the current article.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to publish"}}]}}