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These changes cause hypoxia and cytokine storm with the development of cardio-pulmonary complications. Bioactive lipids and other polyunsaturated fatty acids participate in a vital role in the SARS-CoV-2 infection process. One of these mediators is the anti-inflammatory compound, lipoxin (LX). LXs are produced from arachidonic acid (AA) by collaboration between 5-lipoxygenase (5-LO) and 12\u201315 LO during cell interactions. Thus, our goal was to review the probable role of LXs in COVID-19 regarding the effects of LXs on the inflammatory signaling pathways that are linked with COVID-19 pathogenesis and complications.<\/jats:p>","DOI":"10.1007\/s10787-022-01070-3","type":"journal-article","created":{"date-parts":[[2022,9,16]],"date-time":"2022-09-16T12:03:10Z","timestamp":1663329790000},"page":"1993-2001","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Potential role of lipoxin in the management of COVID-19: a narrative review"],"prefix":"10.1007","volume":"30","author":[{"given":"Gaber El-Saber","family":"Batiha","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali I.","family":"Al-Gareeb","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8287-1026","authenticated-orcid":false,"given":"Engy","family":"Elekhnawy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hayder M.","family":"Al-kuraishy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,9,16]]},"reference":[{"issue":"149","key":"1070_CR1","doi-asserted-by":"publisher","DOI":"10.1016\/j.prostaglandins.2020.106428","volume":"1","author":"W Abma","year":"2020","unstructured":"Abma W, Noreby M, Wheelock CE, Dahlen SE, Adner M, S\u00e4fholm J (2020) Lipoxin A4 reduces house dust mite and TNF\u03b1-induced hyperreactivity in the mouse trachea. 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