{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T16:14:41Z","timestamp":1789748081066,"version":"4.0.1"},"reference-count":96,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2022,11,21]],"date-time":"2022-11-21T00:00:00Z","timestamp":1668988800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2022,11,21]],"date-time":"2022-11-21T00:00:00Z","timestamp":1668988800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Inflammopharmacol"],"published-print":{"date-parts":[[2023,2]]},"DOI":"10.1007\/s10787-022-01100-0","type":"journal-article","created":{"date-parts":[[2022,11,22]],"date-time":"2022-11-22T22:02:35Z","timestamp":1669154555000},"page":"119-128","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Exploring the role of exosomes in rheumatoid arthritis"],"prefix":"10.1007","volume":"31","author":[{"given":"Anuja","family":"Singh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0993-7708","authenticated-orcid":false,"given":"Tapan","family":"Behl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aayush","family":"Sehgal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sukhbir","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neelam","family":"Sharma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maaz","family":"Naqwi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anil","family":"Mavi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Randhir","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,11,21]]},"reference":[{"issue":"7","key":"1100_CR1","doi-asserted-by":"publisher","first-page":"940","DOI":"10.1016\/j.bbagen.2012.03.017","volume":"1820","author":"VV Alexander","year":"2012","unstructured":"Alexander VV, Susan M, Robert S, Rick C (2012) Exosomes: current knowledge of their composition, biological functions, and diagnostic and therapeutic potentials. Biochim Biophys Acta (BBA) 1820(7):940\u2013948. https:\/\/doi.org\/10.1016\/j.bbagen.2012.03.017","journal-title":"Biochim Biophys Acta (BBA)"},{"key":"1100_CR2","doi-asserted-by":"publisher","first-page":"557","DOI":"10.1042\/cs0940557","volume":"94","author":"PJ Barnes","year":"1998","unstructured":"Barnes PJ (1998) Anti-inflammatory actions of glucocorticoids: molecular mechanisms. Clin Sci 94:557\u2013572","journal-title":"Clin Sci"},{"key":"1100_CR3","doi-asserted-by":"publisher","first-page":"3266","DOI":"10.1002\/stem.2093","volume":"33","author":"MJ Barter","year":"2015","unstructured":"Barter MJ, Tselepi M, Gomez R, Woods S, Hui W, Smith GR, Shanley DP, Clark IM, Young DA (2015) Genome-wide MicroRNA and gene analysis of mesenchymal stem cell chondrogenesis identifies an essential role and multiple targets for miR-140-5p. Stem Cells 33:3266\u20133280","journal-title":"Stem Cells"},{"key":"1100_CR4","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1186\/s12951-019-0504-0","volume":"17","author":"CM Beez","year":"2019","unstructured":"Beez CM, Haag M, Klein O, Sophie VL, Michael S, Martina S (2019) Extracellular vesicles from regenerative human cardiac cells act as potent immune modulators by priming monocytes. J Nanobiotechnol 17:72\u201390","journal-title":"J Nanobiotechnol"},{"key":"1100_CR5","doi-asserted-by":"publisher","first-page":"1659","DOI":"10.1111\/j.1600-0854.2011.01225.x","volume":"12","author":"A Bobrie","year":"2011","unstructured":"Bobrie A, Colombo M, Raposo G, Thery C (2011) Exosome secretion: molecular mechanisms and roles in immune responses. Traffic 12:1659\u20131668","journal-title":"Traffic"},{"issue":"2","key":"1100_CR6","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1016\/j.imlet.2015.06.007","volume":"168","author":"S Bruno","year":"2015","unstructured":"Bruno S, Deregibus MC, Camussi G (2015) The secretome of mesenchymal stromal cells: Role of extracellular vesicles in immunomodulation. Immunol Lett 168(2):154\u2013158. https:\/\/doi.org\/10.1016\/j.imlet.2015.06.007","journal-title":"Immunol Lett"},{"key":"1100_CR7","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1186\/s12951-018-0403-9","volume":"16","author":"EJ Bunggulawa","year":"2018","unstructured":"Bunggulawa EJ, Wang W, Yin T, Wang N, Durkan C, Wang Y, Wang G (2018) Recent advancements in the use of exosomes as drug delivery systems. J Nanobiotechnol 16:81\u201394","journal-title":"J Nanobiotechnol"},{"key":"1100_CR8","doi-asserted-by":"publisher","first-page":"39","DOI":"10.3389\/fvets.2017.00039","volume":"4","author":"JG Casado","year":"2017","unstructured":"Casado JG, Blazquez R, Vela FJ, Alvarez V, Tarazona R, Sanchez-Margallo FM (2017) Mesenchymal stem cell-derived exosomes: immunomodulatory evaluation in an antigen-induced synovitis porcine model. Front Vet Sci 4:39","journal-title":"Front Vet Sci"},{"key":"1100_CR9","doi-asserted-by":"publisher","first-page":"831","DOI":"10.1007\/s12026-016-8798-6","volume":"64","author":"W Chen","year":"2016","unstructured":"Chen W, Huang Y, Han J, Yu L, Li Y, Lu Z, Li H, Liu Z, Shi C, Duan F, Xiao Y (2016) Immunomodulatory effects of mesenchymal stromal cells-derived exosome. Immunol Res 64:831\u2013840","journal-title":"Immunol Res"},{"key":"1100_CR10","doi-asserted-by":"publisher","first-page":"1551","DOI":"10.3892\/or.2012.1967","volume":"28","author":"M Chiba","year":"2012","unstructured":"Chiba M (2012) Exosomes secreted from human colorectal cancer cell lines contain mRNAs, microRNAs and natural antisense RNAs, that can transfer into the human hepatoma HepG2 and lung cancer A549 cell lines. Oncol Rep 28:1551\u20131558","journal-title":"Oncol Rep"},{"key":"1100_CR11","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1146\/annurev-cellbio-101512-122326","volume":"30","author":"M Colombo","year":"2014","unstructured":"Colombo M, Raposo G, Thery C (2014) Biogenesis, secretion, and intercellular interactions of exosomes and other extracellular vesicles. Annu Rev Cell Dev Biol 30:255\u2013289","journal-title":"Annu Rev Cell Dev Biol"},{"key":"1100_CR12","doi-asserted-by":"publisher","first-page":"16214","DOI":"10.1038\/s41598-017-15376-8","volume":"7","author":"S Cosenza","year":"2017","unstructured":"Cosenza S, Ruiz M, Toupet K, Jorgensen C, Noel D (2017) Mesenchymal stem cells derived exosomes and microparticles protect cartilage and bone from degradation in osteoarthritis. Sci Rep 7:16214","journal-title":"Sci Rep"},{"key":"1100_CR13","doi-asserted-by":"publisher","first-page":"7254","DOI":"10.1002\/anie.201202713","volume":"51","author":"BJ Crielaard","year":"2012","unstructured":"Crielaard BJ, Rijcken CJF, Quan L, Vander WS, Altintas I, Pot MVD, Kruijtzer JAW, Liskamp RMJ, Schiffelers RM, Nostrum CFV et al (2012) Glucocorticoid-loaded core-cross-linked polymeric micelles with tailorable release kinetics for targeted therapy of rheumatoid arthritis. Angew Chem Int Ed Engl 51:7254\u20137258","journal-title":"Angew Chem Int Ed Engl"},{"key":"1100_CR14","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/4814987","author":"R Domenis","year":"2017","unstructured":"Domenis R, Zanutel R, Caponnetto F, Toffoletto B, Cifu A, Pistis C, Di Benedetto P, Causero A, Pozzi M, Bassini F, Fabris M, Niazi KR, Soon-Shiong P, Curcio F (2017) Characterization of the pro-inflammatory profile of synovial fluid-derived exosomes of patients with osteoarthritis. Mediat Inflamm. https:\/\/doi.org\/10.1155\/2017\/4814987","journal-title":"Mediat Inflamm"},{"key":"1100_CR15","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1038\/nrd3978","volume":"12","author":"S Ela","year":"2013","unstructured":"Ela S, Mager I, Breakefield XO, Wood MJ (2013) Extracellular vesicles: biology and emerging therapeutic opportunities. Nat Rev Drug Discov 12:347\u2013357","journal-title":"Nat Rev Drug Discov"},{"key":"1100_CR16","doi-asserted-by":"publisher","first-page":"1122","DOI":"10.3390\/ijms18061122","volume":"18","author":"KE Gilligan","year":"2017","unstructured":"Gilligan KE, Dwyer RM (2017) Engineering exosomes for cancer therapy. Int J Mol Sci 18:1122","journal-title":"Int J Mol Sci"},{"key":"1100_CR17","doi-asserted-by":"publisher","first-page":"1262","DOI":"10.7150\/ijbs.16150","volume":"12","author":"SC Guo","year":"2016","unstructured":"Guo SC, Tao SC, Yin WJ, Qi X, Sheng JG, Zhang CQ (2016) Exosomes from human synovial-derived mesenchymal stem cells prevent glucocorticoid-induced osteonecrosis of the femoral head in the rat. Int J Biol Sci 12:1262\u20131272","journal-title":"Int J Biol Sci"},{"key":"1100_CR18","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/j.apsb.2016.02.001","volume":"6","author":"D Ha","year":"2016","unstructured":"Ha D, Yang N, Nadithe V (2016) Exosomes as therapeutic drug carriers and delivery vehicles across biological membranes: current perspectives and future challenges. Acta Pharm Sin B 6:9","journal-title":"Acta Pharm Sin B"},{"key":"1100_CR19","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2016\/7653489","volume":"2016","author":"C Han","year":"2016","unstructured":"Han C, Sun X, Liu L, Jiang H, Shen Y, Xu X, Li J, Zhang G, Huang J, Lin Z, Xiong N, Wang T (2016) Exosomes and their therapeutic potentials of stem cells. Stem Cells Int 2016:1\u201311. https:\/\/doi.org\/10.1155\/2016\/7653489","journal-title":"Stem Cells Int"},{"key":"1100_CR20","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1016\/j.jconrel.2015.03.033","volume":"207","author":"MJ Haney","year":"2015","unstructured":"Haney MJ, Klyachko NL, Zhao Y, Gupta R, Plotnikova EG, He Z, Patel T, Piroyan A, Sokolsky M, Kabanov AV, Batrakova EV (2015) Exosomes as drug delivery vehicles for Parkinson\u2019s disease therapy. JCR 207:18\u201330","journal-title":"JCR"},{"key":"1100_CR21","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1007\/s00018-017-2595-9","volume":"75","author":"NP Hessvik","year":"2018","unstructured":"Hessvik NP, Llorente A (2018) Current knowledge on exosome biogenesis and release. Cell Mol Life Sci 75:193\u2013208","journal-title":"Cell Mol Life Sci"},{"key":"1100_CR22","doi-asserted-by":"publisher","first-page":"583","DOI":"10.3389\/fphar.2017.00583","volume":"8","author":"KW Hon","year":"2017","unstructured":"Hon KW, Abu N, Ab Mutalib NS, Jamal R (2017) Exosomes as potential biomarkers and targeted therapy in colorectal cancer: a mini-review. Front Pharmacolo 8:583","journal-title":"Front Pharmacolo"},{"key":"1100_CR23","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1016\/j.ab.2013.12.001","volume":"448","author":"JL Hood","year":"2014","unstructured":"Hood JL, Scott MJ, Wickline SA (2014) Maximizing exosome colloidal stability following electroporation. Anal Biochem 448:41\u201349","journal-title":"Anal Biochem"},{"key":"1100_CR24","doi-asserted-by":"publisher","first-page":"240","DOI":"10.1159\/000484677","volume":"44","author":"F Huang","year":"2017","unstructured":"Huang F, Wan J, Hu W, Hao S (2017) Enhancement of anti-leukemia immunity by leukemia-derived exosomes via downregulation of TGF-beta1 expression. Cell Physiol Biochem 44:240\u2013254","journal-title":"Cell Physiol Biochem"},{"key":"1100_CR25","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1038\/gt.2017.8","volume":"24","author":"L Jiang","year":"2017","unstructured":"Jiang L, Vader P, Schiffelers RM (2017) Extracellular vesicles for nucleic acid delivery: progress and prospects for safe RNA-based gene therapy. Gene Ther 24:157\u2013166","journal-title":"Gene Ther"},{"key":"1100_CR26","doi-asserted-by":"publisher","first-page":"2125","DOI":"10.1007\/s10616-016-9952-7","volume":"68","author":"KB Johnsen","year":"2016","unstructured":"Johnsen KB, Gudbergsson JM, Skov MN, Christiansen G, Gurevich L, Moos T, Duroux M (2016) Evaluation of electroporation-induced adverse effects on adipose-derived stem cell exosomes. Cytotechnology 68:2125\u20132138","journal-title":"Cytotechnology"},{"issue":"2","key":"1100_CR27","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1016\/j.bcmd.2005.12.001","volume":"36","author":"RM Johnstone","year":"2006","unstructured":"Johnstone RM (2006) Exosomes biological significance: a concise review. Blood Cells Mol Dis 36(2):315\u2013321. https:\/\/doi.org\/10.1016\/j.bcmd.2005.12.001","journal-title":"Blood Cells Mol Dis"},{"key":"1100_CR28","doi-asserted-by":"publisher","first-page":"769","DOI":"10.3892\/ijmm.2013.1269","volume":"31","author":"J Ju","year":"2013","unstructured":"Ju J (2013) Temporal differential effects of proinflammatory cytokines on osteoclastogenesis. Int J Mol Med 31:769\u2013777","journal-title":"Int J Mol Med"},{"key":"1100_CR29","doi-asserted-by":"publisher","first-page":"R163","DOI":"10.1186\/ar4679","volume":"16","author":"T Kato","year":"2014","unstructured":"Kato T, Miyaki S, Ishitobi H, Nakamura Y, Nakasa T, Lotz MK, Ochi M (2014) Exosomes from IL-1beta stimulated synovial fibroblasts induce osteoarthritic changes in articular chondrocytes. Arthritis Res Ther 16:R163","journal-title":"Arthritis Res Ther"},{"key":"1100_CR30","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1016\/j.tips.2015.02.001","volume":"36","author":"MI Koenders","year":"2015","unstructured":"Koenders MI, VandenBerg WB (2015) Novel therapeutic targets in rheumatoid arthritis. Trends Pharmacol Sci 36:189\u2013195","journal-title":"Trends Pharmacol Sci"},{"key":"1100_CR31","doi-asserted-by":"publisher","first-page":"2029","DOI":"10.1038\/s41598-017-01905-y","volume":"7","author":"R Kolhe","year":"2017","unstructured":"Kolhe R, Hunter M, Liu S, Jadeja RN, Pundkar C, Mondal AK, Mendhe B, Drewry M, Rojiani MV, Liu Y, Isales CM, Guldberg RE, Hamrick MW, Fulzele S (2017) Gender-specific differential expression of exosomal miRNA in synovial fluid of patients with osteoarthritis. Sci Rep 7:2029","journal-title":"Sci Rep"},{"key":"1100_CR32","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1016\/j.jconrel.2016.01.009","volume":"224","author":"SAA Kooijmans","year":"2016","unstructured":"Kooijmans SAA, Fliervoet LAL, van der Meel R, Fens MHAM, Heijnen HFG, van Bergen HPMP, Vader P, Schiffelers RM (2016) PEGylated and targeted extracellular vesicles display enhanced cell specificity and circulation time. JCR 224:77\u201385","journal-title":"JCR"},{"key":"1100_CR33","doi-asserted-by":"publisher","first-page":"543","DOI":"10.1016\/j.biotechadv.2012.08.008","volume":"31","author":"RC Lai","year":"2012","unstructured":"Lai RC, Yeo RWY, Tan KH, Lim SK (2012) Exosomes for drug delivery\u2014a novel application for the mesenchymal stem cell. Biotechnol Adv 31:543\u2013551","journal-title":"Biotechnol Adv"},{"key":"1100_CR34","doi-asserted-by":"publisher","first-page":"594","DOI":"10.1016\/j.autrev.2017.04.005","volume":"16","author":"A Leblond","year":"2017","unstructured":"Leblond A, Allanore Y, Avouac J (2017) Targeting synovial neoangiogenesis in rheumatoid arthritis. Autoimmun Rew 16:594\u2013601","journal-title":"Autoimmun Rew"},{"key":"1100_CR35","doi-asserted-by":"publisher","first-page":"1770","DOI":"10.1158\/0008-5472.CAN-15-1625","volume":"76","author":"L Li","year":"2016","unstructured":"Li L, Li C, Wang S, Wang Z, Jiang J, Wang W, Li X, Chen J, Liu K, Li C, Zhu G (2016) Exosomes derived from hypoxic oral squamous cell carcinoma cells deliver miR-21 to normoxic cells to elicit a prometastatic phenotype. Cancer Res 76:1770\u20131780","journal-title":"Cancer Res"},{"key":"1100_CR36","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1016\/j.jconrel.2016.12.027","volume":"246","author":"C Li","year":"2017","unstructured":"Li C, Li H, Wang Q, Zhou M, Li M, Gong T, Zhang Z, Sun X (2017a) pH-sensitive polymeric micelles for targeted delivery to inflamed joints. JCR 246:133\u2013141","journal-title":"JCR"},{"key":"1100_CR37","doi-asserted-by":"publisher","first-page":"1379","DOI":"10.1002\/cbin.10869","volume":"41","author":"H Li","year":"2017","unstructured":"Li H, Liu D, Li C, Zhou S, Tian D, Xiao D, Zhang H, Gao F, Huang J (2017b) Exosomes secreted from mutant-HIF-1alpha-modified bone-marrow-derived mesenchymal stem cells attenuate early steroid-induced avascular necrosis of femoral head in rabbit. Cell Biol Int 41:1379\u20131390","journal-title":"Cell Biol Int"},{"key":"1100_CR38","doi-asserted-by":"publisher","first-page":"1741","DOI":"10.1159\/000485780","volume":"44","author":"XJ Li","year":"2017","unstructured":"Li XJ, Ren ZJ, Tang JH, Yu Q (2017c) Exosomal microRNA MiR-1246 promotes cell proliferation, invasion and drug resistance by targeting CCNG2 in breast cancer. Cell Physiol Biochem 44:1741\u20131817","journal-title":"Cell Physiol Biochem"},{"key":"1100_CR39","doi-asserted-by":"publisher","first-page":"1145","DOI":"10.1016\/j.apsb.2019.08.003","volume":"9","author":"C Li","year":"2019","unstructured":"Li C, Wang J, Wang Y, Gao H, Wei G, Huang Y, Yu H, Gan Y, Wang Y, Mei L, Chen H, Hu H, Zhang Z, Jin Y (2019) Recent progress in drug delivery. Acta Pharm Sin b 9:1145\u20131162","journal-title":"Acta Pharm Sin b"},{"key":"1100_CR40","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1016\/j.jconrel.2019.08.037","volume":"311","author":"Q Lin","year":"2019","unstructured":"Lin Q, Qu M, Zhou B, Patra HK, Sun Z, Luo Q, Yang W, Wu Y, Zhang Y, Li L et al (2019) Exosome-like Nano-platform modified with targeting ligand improves anti-cancer and anti-inflammation effects of imperialine. JCR 311:104\u2013116","journal-title":"JCR"},{"key":"1100_CR41","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0107001","volume":"9","author":"I Linero","year":"2014","unstructured":"Linero I, Chaparro O (2014) Paracrine effect of mesenchymal stem cells derived from human adipose tissue in bone regeneration. PLoS ONE 9:e107001","journal-title":"PLoS ONE"},{"key":"1100_CR42","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1159\/000480317","volume":"43","author":"L Liu","year":"2017","unstructured":"Liu L, Jin X, Hu CF, Li R, Zhou Z, Shen CX (2017a) Exosomes derived from mesenchymal stem cells rescue myocardial ischaemia\/reperfusion injury by inducing cardiomyocyte autophagy via AMPK and Akt pathways. Cell Physiol Biochem 43:52\u201368","journal-title":"Cell Physiol Biochem"},{"key":"1100_CR43","doi-asserted-by":"publisher","first-page":"232","DOI":"10.7150\/ijbs.16951","volume":"13","author":"X Liu","year":"2017","unstructured":"Liu X, Li Q, Niu X, Hu B, Chen S, Song W, Ding J, Zhang C, Wang Y (2017b) Exosomes secreted from human-induced pluripotent stem cell-derived mesenchymal stem cells prevent osteonecrosis of the femoral head by promoting angiogenesis. Int J Biol Sci 13:232\u2013244","journal-title":"Int J Biol Sci"},{"key":"1100_CR44","doi-asserted-by":"publisher","first-page":"4430","DOI":"10.1039\/C7NR00352H","volume":"9","author":"XL Liu","year":"2017","unstructured":"Liu XL, Yang YL, Li Y, Niu X, Zhao BZ, Wang Y, Bao CY, Xie ZP, Lin QN, Zhu LY (2017c) Integration of stem cell-derived exosomes with in situ hydrogel glue as a promising tissue patch for articular cartilage regeneration. Nanoscale 9:4430\u20134438","journal-title":"Nanoscale"},{"key":"1100_CR45","doi-asserted-by":"publisher","first-page":"27031","DOI":"10.3402\/jev.v4.27031","volume":"4","author":"RJ Lobb","year":"2015","unstructured":"Lobb RJ, Becker M, Wen SW, Wong CS, Wiegmans AP, Leimgruber A, Moller A (2015) Optimized exosome isolation protocol for cell culture supernatant and human plasma. J Extracell Vesicles 4:27031","journal-title":"J Extracell Vesicles"},{"key":"1100_CR46","doi-asserted-by":"publisher","first-page":"2105","DOI":"10.1159\/000485949","volume":"44","author":"Q Luo","year":"2017","unstructured":"Luo Q, Guo D, Liu G, Chen G, Hang M, Jin M (2017) Exosomes from MiR-126-overexpressing Adscs are therapeutic in relieving acute myocardial ischaemic injury. Cell Physiol Biochem 44:2105\u20132116","journal-title":"Cell Physiol Biochem"},{"key":"1100_CR47","doi-asserted-by":"publisher","first-page":"386","DOI":"10.1049\/iet-nbt.2015.0018","volume":"9","author":"N Mehrotra","year":"2015","unstructured":"Mehrotra N, Tripathi RM (2015) Short interfering RNA therapeutics: nanocarriers, prospects and limitations. IET Nanobiotechnol 9:386\u2013395","journal-title":"IET Nanobiotechnol"},{"key":"1100_CR48","doi-asserted-by":"publisher","first-page":"967","DOI":"10.1016\/0092-8674(83)90040-5","volume":"33","author":"BT Pan","year":"1983","unstructured":"Pan BT, Johnstone RM (1983) Fate of the transferrin receptor during maturation of sheep reticulocytes in vitro: selective externalization of the receptor. Cell 33:967\u2013978","journal-title":"Cell"},{"key":"1100_CR49","doi-asserted-by":"publisher","first-page":"2453","DOI":"10.1007\/s00198-014-2779-1","volume":"25","author":"JL Pathak","year":"2014","unstructured":"Pathak JL, Bravenboer N, Verschueren P, Lems WF, Luyten FP, Klein-Nulend J, Bakker AD (2014) Inflammatory factors in the circulation of patients with active rheumatoid arthritis stimulate osteoclastogenesis via endogenous cytokine production by osteoblasts. Osteoporos Int 25:2453\u20132463","journal-title":"Osteoporos Int"},{"key":"1100_CR50","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0138618","volume":"10","author":"J Perez-Hernandez","year":"2015","unstructured":"Perez-Hernandez J, Forner MJ, Pinto C, Chaves FJ, Cortes R, Redon J (2015) Increased urinary exosomal microRNAs in patients with systemic lupus erythematosus. PLoS ONE 10:e0138618","journal-title":"PLoS ONE"},{"key":"1100_CR51","doi-asserted-by":"publisher","first-page":"1","DOI":"10.2217\/nnm.15.45","volume":"10","author":"LK Prasad","year":"2015","unstructured":"Prasad LK, O\u2019Mary H, Cui Z (2015) Nanomedicine delivers promising treatments for rheumatoid arthritis. Nanomed 10:1\u201312","journal-title":"Nanomed"},{"key":"1100_CR52","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1016\/j.jconrel.2018.08.035","volume":"287","author":"M Qu","year":"2018","unstructured":"Qu M, Lin Q, Huang L, Fu Y, Wang L, He S, Fu Y, Yang S, Zhang Z, Zhang L, Sun X (2018) Dopamine-loaded blood exosomes targeted to brain for better treatment of Parkinson\u2019s disease. JCR 287:156\u2013166","journal-title":"JCR"},{"key":"1100_CR53","doi-asserted-by":"publisher","first-page":"458","DOI":"10.1021\/nn4048205","volume":"8","author":"L Quan","year":"2014","unstructured":"Quan L, Zhang Y, Crielaard BJ, Dusad A, Lele SM, Rijcken CJF, Metselaar JM, Kostkova H, Etrych T, Ulbrich K et al (2014) Nanomedicines for inflammatory arthritis: head-to-head comparison of glucocorticoid-containing polymers, micelles, and liposomes. ACS Nano 8:458\u2013466","journal-title":"ACS Nano"},{"key":"1100_CR54","doi-asserted-by":"publisher","first-page":"186","DOI":"10.1007\/s11095-015-1776-1","volume":"33","author":"L Quan","year":"2016","unstructured":"Quan L, Zhang Y, Dusad A, Ren K, Purdue PE, Goldring SR, Wang D (2016) The evaluation of the therapeutic efficacy and side effects of a macromolecular dexamethasone prodrug in the collagen-induced arthritis mouse model. Pharm Res 33:186\u2013193","journal-title":"Pharm Res"},{"key":"1100_CR55","first-page":"147","volume":"5","author":"A Reumson","year":"2015","unstructured":"Reumson A, Kim DY, Hun PS, Yong J, Kim K, Ju KB, Yin XY, Kim JH, Min BH, Han DK, Kim MS (2015) Direct chemotherapeutic dual drug delivery through intra-articular injection for synergistic enhancement of rheumatoid arthritis treatment. Sci Rep 5:147\u2013153","journal-title":"Sci Rep"},{"key":"1100_CR56","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1000341","volume":"7","author":"B Rhodes","year":"2010","unstructured":"Rhodes B, Merriman ME, Harrison A, Nissen MJ, Smith M, Stamp L, Steer S, Merriman TR, Vyse TJ (2010) A genetic association study of serum acute-phase C-reactive protein levels in rheumatoid arthritis: implications for clinical interpretation. PLoS Med 7:e1000341","journal-title":"PLoS Med"},{"key":"1100_CR57","doi-asserted-by":"publisher","first-page":"594","DOI":"10.3899\/jrheum.111073","volume":"39","author":"I Sari","year":"2012","unstructured":"Sari I, Bozkaya G, Kirbiyik H, Alacacioglu A, Ates H, Sop G, Can G, Taylan A, Piskin O, Yildiz Y, Akkoc N (2012) Evaluation of circulating endothelial and platelet microparticles in men with ankylosing spondylitis. J Rheumatol 39:594\u2013599","journal-title":"J Rheumatol"},{"key":"1100_CR58","first-page":"275","volume":"26","author":"P Siafaka","year":"2015","unstructured":"Siafaka P, Betsiou M, Tsolou A, Angelou E, Bikiari D (2015) Synthesis of folate-pegylated polyester nanoparticles encapsulating ixabepilone for targeting folate receptor overexpressing breast cancer cells. Deliv Sys 26:275\u2013289","journal-title":"Deliv Sys"},{"issue":"4","key":"1100_CR59","doi-asserted-by":"publisher","first-page":"575","DOI":"10.1016\/j.ceb.2009.03.007","volume":"21","author":"M Simons","year":"2009","unstructured":"Simons M, Raposo G (2009) Exosomes\u2014vesicular carriers for intercellular communication. Curr Opin Cell Biol 21(4):575\u2013581. https:\/\/doi.org\/10.1016\/j.ceb.2009.03.007","journal-title":"Curr Opin Cell Biol"},{"key":"1100_CR60","doi-asserted-by":"publisher","first-page":"777","DOI":"10.4049\/jimmunol.1103638","volume":"189","author":"PP Singh","year":"2012","unstructured":"Singh PP, Smith VL, Karakousis PC, Schorey JS (2012) Exosomes isolated from mycobacteria-infected mice or cultured macrophages can recruit and activate immune cells in vitro and in vivo. J Immunol 189:777\u2013785","journal-title":"J Immunol"},{"key":"1100_CR61","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1016\/j.plipres.2017.03.001","volume":"66","author":"T Skotland","year":"2017","unstructured":"Skotland T, Sandvig K, Llorente A (2017) Lipids in exosomes: current knowledge and the way forward. Prog Lipid Res 66:30\u201341","journal-title":"Prog Lipid Res"},{"key":"1100_CR62","doi-asserted-by":"publisher","first-page":"462","DOI":"10.1016\/j.apsb.2019.11.004","volume":"10","author":"HS Son","year":"2020","unstructured":"Son HS, Lee J, Lee HI, Kim N, Jo YJ, Lee GR et al (2020) Benzydamine inhibits osteoclast differentiation and bone resorption via down-regulation of interleukin-1\u03b2 expression. Acta Pharm Sin b 10:462\u2013474","journal-title":"Acta Pharm Sin b"},{"key":"1100_CR63","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1007\/s10238-013-0271-4","volume":"15","author":"J Song","year":"2015","unstructured":"Song J, Kim D, Han J, Kim Y, Lee M, Jin EJ (2015) PBMC and exosome-derived Hotair is a critical regulator and potent marker for rheumatoid arthritis. Clin Exp Med 15:121\u2013126","journal-title":"Clin Exp Med"},{"issue":"5","key":"1100_CR64","doi-asserted-by":"publisher","first-page":"1432","DOI":"10.1016\/j.celrep.2014.07.035","volume":"8","author":"ML Squadrito","year":"2014","unstructured":"Squadrito ML, Baer C, Burdet F, Maderna C, Gilfillan GD, Lyle R, Ibberson M, De Palma M (2014) Endogenous RNAs modulate microRNA sorting to exosomes and transfer to acceptor cells. Cell Rep 8(5):1432\u20131446. https:\/\/doi.org\/10.1016\/j.celrep.2014.07.035","journal-title":"Cell Rep"},{"key":"1100_CR65","doi-asserted-by":"publisher","first-page":"4740","DOI":"10.7150\/thno.33520","volume":"9","author":"TT Tang","year":"2019","unstructured":"Tang TT, Lv LL, Wang B, Cao JY, Feng Y, Li ZL, Li ZL, Wu M, Wang FM, Wen Y et al (2019) Employing macrophage-derived microvesicle for kidney-targeted delivery of dexamethasone: an efficient therapeutic strategy against renal inflammation and fibrosis. Theranostics 9:4740\u20134755","journal-title":"Theranostics"},{"key":"1100_CR66","doi-asserted-by":"publisher","first-page":"733","DOI":"10.7150\/thno.17450","volume":"7","author":"SC Tao","year":"2017","unstructured":"Tao SC, Yuan T, Rui BY, Zhu ZZ, Guo SC, Zhang CQ (2017a) Exosomes derived from human platelet-rich plasma prevent apoptosis induced by glucocorticoid-associated endoplasmic reticulum stress in rat osteonecrosis of the femoral head via the Akt\/Bad\/Bcl-2 signal pathway. Theranostics 7:733\u2013750","journal-title":"Theranostics"},{"key":"1100_CR67","doi-asserted-by":"publisher","first-page":"180","DOI":"10.7150\/thno.17133","volume":"7","author":"SC Tao","year":"2017","unstructured":"Tao SC, Yuan T, Zhang YL, Yin WJ, Guo SC, Zhang CQ (2017b) Exosomes derived from miR-140-5p-overexpressing human synovial mesenchymal stem cells enhance cartilage tissue regeneration and prevent osteoarthritis of the knee in a rat model. Theranostics 7:180\u2013195","journal-title":"Theranostics"},{"key":"1100_CR68","doi-asserted-by":"publisher","first-page":"2671","DOI":"10.1002\/art.30459","volume":"63","author":"TP Thomas","year":"2011","unstructured":"Thomas TP, Goonewardena SN, Majoros IJ, Kotlyar A, Cao Z, Leroueil PR, Baker JR (2011) Folate-targeted nanoparticles show efficacy in the treatment of inflammatory arthritis. Arthritis Rheum 63:2671\u20132780","journal-title":"Arthritis Rheum"},{"key":"1100_CR69","doi-asserted-by":"publisher","first-page":"2383","DOI":"10.1016\/j.biomaterials.2013.11.083","volume":"35","author":"Y Tian","year":"2014","unstructured":"Tian Y, Li S, Song J, Ji T, Zhu M, Anderson GJ (2014) A doxorubicin delivery platform using engineered natural membrane vesicle exosomes for targeted tumor therapy. Biomaterials 35:2383\u20132390","journal-title":"Biomaterials"},{"key":"1100_CR70","doi-asserted-by":"publisher","first-page":"1226","DOI":"10.1016\/j.cell.2016.01.043","volume":"164","author":"M Tkach","year":"2016","unstructured":"Tkach M, Thery C (2016) Communication by extracellular vesicles: where we are and where we need to go. Cell 164:1226\u20131232","journal-title":"Cell"},{"issue":"1","key":"1100_CR71","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1016\/j.clim.2015.03.021","volume":"160","author":"T-H Tran","year":"2015","unstructured":"Tran T-H, Mattheolabakis G, Aldawsari H, Amiji M (2015) Exosomes as nanocarriers for immunotherapy of cancer and inflammatory diseases. Clin Immunol 160(1):46\u201358. https:\/\/doi.org\/10.1016\/j.clim.2015.03.021","journal-title":"Clin Immunol"},{"key":"1100_CR72","doi-asserted-by":"publisher","first-page":"654","DOI":"10.1038\/ncb1596","volume":"9","author":"H Valadi","year":"2007","unstructured":"Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO (2007) Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells. Nat Cell Biol 9:654-U672","journal-title":"Nat Cell Biol"},{"key":"1100_CR73","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1016\/j.tem.2017.10.010","volume":"29","author":"J Vandewalle","year":"2017","unstructured":"Vandewalle J, Luypaert A, Bosscher KD, Libert C (2017) Therapeutic mechanisms of glucocorticoids. Trends Endocrinol Metab 29:42\u2013544","journal-title":"Trends Endocrinol Metab"},{"key":"1100_CR74","doi-asserted-by":"publisher","first-page":"1407","DOI":"10.1039\/C7BM00254H","volume":"5","author":"Q Wang","year":"2017","unstructured":"Wang Q, Sun X (2017) Recent advances in nanomedicines for the treatment of rheumatoid arthritis. Biomater Sci 5:1407\u20131420","journal-title":"Biomater Sci"},{"key":"1100_CR75","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1016\/j.jconrel.2016.03.035","volume":"230","author":"Q Wang","year":"2016","unstructured":"Wang Q, Jiang J, Chen W, Jiang H, Zhang Z, Sun X (2016) Targeted delivery of low-dose dexamethasone using PCL\u2013PEG micelles for effective treatment of rheumatoid arthritis. JCR 230:64\u201372","journal-title":"JCR"},{"key":"1100_CR76","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1016\/j.biomaterials.2017.01.008","volume":"122","author":"Q Wang","year":"2017","unstructured":"Wang Q, Jiang H, Li Y, Chen W, Li H, Peng K, Zhang Z, Sun X (2017a) Targeting NF-kB signaling with polymeric hybrid micelles that co-deliver siRNA and dexamethasone for arthritis therapy. Biomaterials 122:10\u201322","journal-title":"Biomaterials"},{"key":"1100_CR77","doi-asserted-by":"publisher","first-page":"48460","DOI":"10.18632\/oncotarget.17223","volume":"8","author":"Y Wang","year":"2017","unstructured":"Wang Y, Wang Q, Wei X, Shao J, Zhao J, Zhang Z, Chen Z, Bai Y, Wang N, Wang Y, Li M, Zhai X (2017b) Global scientific trends on exosome research during 2007\u20132016: a bibliometric analysis. Oncotarget 8:48460\u201348470","journal-title":"Oncotarget"},{"issue":"8","key":"1100_CR78","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1186\/s13287-017-0632-0","volume":"14","author":"YF Wang","year":"2017","unstructured":"Wang YF, Yu DS, Liu ZM, Zhou F, Dai J, Wu BB, Zhou J, Heng BC, Zou XH, Ouyang HW, Liu H (2017c) Exosomes from embryonic mesenchymal stem cells alleviate osteoarthritis through balancing synthesis and degradation of cartilage extracellular matrix. Stem Cell Res Therap 14(8):189","journal-title":"Stem Cell Res Therap"},{"key":"1100_CR79","doi-asserted-by":"publisher","first-page":"708","DOI":"10.7150\/thno.30418","volume":"9","author":"Y Wang","year":"2019","unstructured":"Wang Y, Liu Z, Li T, Chen L, Lyu J, Li C, Lin Y, Hao N, Zhou M, Zhong Z (2019) Enhanced therapeutic effect of RGD-modified polymeric micelles loaded with low-dose methotrexate and nimesulide on rheumatoid arthritis. Theranostics 9:708\u2013720","journal-title":"Theranostics"},{"key":"1100_CR80","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1007\/s00011-017-1116-5","volume":"67","author":"B Williams","year":"2018","unstructured":"Williams B, Dharmapatni A, Crotti T (2018) Intracellular apoptotic pathways: a potential target for reducing joint damage in rheumatoid arthritis. Inflamm Res 67:219\u2013231","journal-title":"Inflamm Res"},{"key":"1100_CR81","first-page":"456","volume":"15","author":"J Wu","year":"2018","unstructured":"Wu J, Xin W, Gang Z, Josselyn G, Xiaoyan W, Liu Y, Dhruvkumar MS, Purdue PE, Mikuls TR, Goldring SR, Wang D (2018) Development of a Janus Kinase (JAK) inhibitor prodrug for the treatment of rheumatoid arthritis. Mol Pharm 15:456\u20133467","journal-title":"Mol Pharm"},{"key":"1100_CR82","doi-asserted-by":"publisher","first-page":"4068","DOI":"10.1002\/anie.201913700","volume":"59","author":"G Wu","year":"2020","unstructured":"Wu G, Zhang J, Zhao Q, Zhuang W, Ding J, Zhang C, Gao H, Pang D, Pu K, Xie H (2020) Molecularly engineered macrophage-derived exosomes with inflammation tropism and intrinsic heme biosynthesis for atherosclerosis treatment. Angew Chem Int Ed Engl 59:4068\u20134074","journal-title":"Angew Chem Int Ed Engl"},{"key":"1100_CR83","doi-asserted-by":"publisher","first-page":"1717","DOI":"10.1007\/s10853-012-6930-0","volume":"48","author":"KK Yang","year":"2013","unstructured":"Yang KK, Kong M, Wei YN, Liu Y, Cheng XJ, Li J, Park HJ, Chen XG (2013) Folate-modified\u2013chitosan-coated liposomes for tumor-targeted drug delivery. J Mater Sci 48:1717\u20131728","journal-title":"J Mater Sci"},{"key":"1100_CR84","doi-asserted-by":"publisher","first-page":"2003","DOI":"10.1007\/s11095-014-1593-y","volume":"32","author":"T Yang","year":"2015","unstructured":"Yang T, Martin P, Fogarty B, Brown A, Schurman K, Phipps R (2015) Exosome delivered anticancer drugs across the blood-brain barrier for brain cancer therapy in Danio Rerio. Pharmac Res 32:2003\u20132144","journal-title":"Pharmac Res"},{"key":"1100_CR85","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1186\/s13075-017-1334-9","volume":"19","author":"J Yoo","year":"2017","unstructured":"Yoo J, Lee SK, Lim M, Sheen D, Choi EH, Kim SA (2017) Exosomal amyloid A and lymphatic vessel endothelial hyaluronic acid receptor-1 proteins are associated with disease activity in rheumatoid arthritis. Arthritis Res Ther 19:119","journal-title":"Arthritis Res Ther"},{"key":"1100_CR86","doi-asserted-by":"publisher","first-page":"1902","DOI":"10.1093\/rheumatology\/kex270","volume":"56","author":"D Yu","year":"2017","unstructured":"Yu D, Jordan KP, Bedson J, Englund M, Blyth F, Turkiewicz A, Prieto-Alhambra D, Peat G (2017) Population trends in the incidence and initial management of osteoarthritis: age-period-cohort analysis of the clinical practice research datalink, 1992\u20132013. Rheumatology (oxford) 56:1902\u20131917","journal-title":"Rheumatology (oxford)"},{"key":"1100_CR87","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.biomaterials.2017.07.011","volume":"142","author":"D Yuan","year":"2017","unstructured":"Yuan D, Zhao Y, Banks WA, Bullock KM, Haney M, Batrakova E, Kabanov AV (2017) Macrophage exosomes as natural nanocarriers for protein delivery to inflamed brain. Biomaterials 142:1\u201312","journal-title":"Biomaterials"},{"key":"1100_CR88","doi-asserted-by":"publisher","first-page":"7385","DOI":"10.4049\/jimmunol.176.12.7385","volume":"176","author":"HG Zhang","year":"2006","unstructured":"Zhang HG, Liu C, Su K, Yu S, Zhang L, Zhang S, Wang J, Cao X, Grizzle W, Kimberly RP (2006) A membrane form of TNF-alpha presented by exosomes delays T cell activation-induced cell death. J Immunol 176:7385\u20137393","journal-title":"J Immunol"},{"key":"1100_CR89","doi-asserted-by":"publisher","first-page":"1701","DOI":"10.3892\/ol.2014.2373","volume":"8","author":"Z Zhang","year":"2014","unstructured":"Zhang Z, Wang C, Li T, Liu Z, Li L (2014) Comparison of ultracentrifugation and density gradient separation methods for isolating Tca8113 human tongue cancer cell line derived exosomes. Oncol Lett 8:1701\u20131706","journal-title":"Oncol Lett"},{"key":"1100_CR90","doi-asserted-by":"publisher","first-page":"2135","DOI":"10.1016\/j.joca.2016.06.022","volume":"24","author":"S Zhang","year":"2016","unstructured":"Zhang S, Chu WC, Lai RC, Lim SK, Hui JH, Toh WS (2016) Exosomes derived from human embryonic mesenchymal stem cells promote osteochondral regeneration. Osteoarthr Cartil 24:2135\u20132140","journal-title":"Osteoarthr Cartil"},{"key":"1100_CR91","doi-asserted-by":"publisher","first-page":"755","DOI":"10.1159\/000458736","volume":"41","author":"W Zhang","year":"2017","unstructured":"Zhang W, Xia W, Lv Z, Ni C, Xin Y, Yang L (2017) Liquid biopsy for cancer: circulating tumor cells, circulating free DNA or exosomes? Cell Physiol Biochem 41:755\u2013768","journal-title":"Cell Physiol Biochem"},{"key":"1100_CR92","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.jconrel.2019.12.005","volume":"318","author":"L Zhao","year":"2020","unstructured":"Zhao L, Gu C, Gan Y, Shao L, Chen H, Zhu H (2020) Exosome-mediated siRNA delivery to suppress postoperative breast cancer metastasis. JCR 318:1\u201315","journal-title":"JCR"},{"key":"1100_CR93","doi-asserted-by":"publisher","first-page":"758","DOI":"10.1002\/wrna.1363","volume":"7","author":"Y Zhou","year":"2016","unstructured":"Zhou Y, Zhou G, Tian C, Jiang W, Jin L, Zhang C, Chen X (2016) Exosome-mediated small RNA delivery for gene therapy. Wiley Interdiscip Rev RNA 7:758\u2013771","journal-title":"Wiley Interdiscip Rev RNA"},{"key":"1100_CR94","doi-asserted-by":"publisher","first-page":"716","DOI":"10.1080\/10717544.2018.1447050","volume":"25","author":"M Zhou","year":"2018","unstructured":"Zhou M, Hou J, Zhong Z, Hao N, Lin Y, Li C (2018) Targeted delivery of hyaluronic acid-coated solid lipid nanoparticles for rheumatoid arthritis therapy. Drug Deliv 25:716\u2013722","journal-title":"Drug Deliv"},{"key":"1100_CR95","doi-asserted-by":"publisher","first-page":"276","DOI":"10.1302\/2046-3758.56.BJR-2015-0014.R1","volume":"5","author":"HY Zhu","year":"2016","unstructured":"Zhu HY, Gao YC, Wang Y, Zhang CQ (2016) Circulating exosome levels in the diagnosis of steroid-induced osteonecrosis of the femoral head. Bone Joint Res 5:276\u2013279","journal-title":"Bone Joint Res"},{"key":"1100_CR96","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1186\/s13287-017-0510-9","volume":"8","author":"Y Zhu","year":"2017","unstructured":"Zhu Y, Wang Y, Zhao B, Niu X, Hu B, Li Q, Zhang J, Ding J, Chen Y, Wang Y (2017) Comparison of exosomes secreted by induced pluripotent stem cell-derived mesenchymal stem cells and synovial membrane-derived mesenchymal stem cells for the treatment of osteoarthritis. Stem Cell Res Ther 8:64","journal-title":"Stem Cell Res Ther"}],"container-title":["Inflammopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10787-022-01100-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10787-022-01100-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10787-022-01100-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,24]],"date-time":"2023-02-24T10:24:29Z","timestamp":1677234269000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10787-022-01100-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11,21]]},"references-count":96,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2023,2]]}},"alternative-id":["1100"],"URL":"https:\/\/doi.org\/10.1007\/s10787-022-01100-0","relation":{},"ISSN":["0925-4692","1568-5608"],"issn-type":[{"value":"0925-4692","type":"print"},{"value":"1568-5608","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,11,21]]},"assertion":[{"value":"7 July 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 November 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 November 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declared that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"All authors have given consent for publication of the current article.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to publish"}}]}}