{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T16:01:41Z","timestamp":1787500901132,"version":"build-2736575974"},"reference-count":50,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2022,11,29]],"date-time":"2022-11-29T00:00:00Z","timestamp":1669680000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2022,11,29]],"date-time":"2022-11-29T00:00:00Z","timestamp":1669680000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Inflammopharmacol"],"published-print":{"date-parts":[[2023,2]]},"DOI":"10.1007\/s10787-022-01103-x","type":"journal-article","created":{"date-parts":[[2022,11,29]],"date-time":"2022-11-29T02:24:31Z","timestamp":1669688671000},"page":"411-422","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Pharmacological evaluation of antinociceptive and anti-inflammatory activities of LQFM202: a new piperazine derivative"],"prefix":"10.1007","volume":"31","author":[{"given":"Aline N.","family":"Martins","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dionys","family":"de Souza Almeida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iziara F.","family":"Florentino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorrane K.","family":"da Silva Moreira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Larissa C.","family":"Turones","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel C.","family":"Batista","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucas S.","family":"Machado","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boniek G.","family":"Vaz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luciano M.","family":"Li\u00e3o","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerlon","family":"de Almeida Ribeiro Oliveira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Lu\u00eds Rodrigues","family":"Martins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James Oluwagbamigbe","family":"Fajemiroye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricardo","family":"Menegatti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elson A.","family":"Costa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8003-7740","authenticated-orcid":false,"given":"Daiany P. B.","family":"da Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,11,29]]},"reference":[{"issue":"886","key":"1103_CR1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2020.173388","volume":"5","author":"DS Almeida","year":"2020","unstructured":"Almeida DS, da Silva DPB, Moreira LKDS, Menegatti R, Li\u00e3o LM, Sanz G, Vaz BG, Ghedini PC, Costa EA, Florentino IF (2020) Investigation of anti-inflammatory potential of 5-(3,5-di-tert-butyl-4-hydroxybenzylidene)-2-thioxodihydropyrimidine-4,6(1H,5H)-dione compound. Eur J Pharmacol 5(886):173388. https:\/\/doi.org\/10.1016\/j.ejphar.2020.173388","journal-title":"Eur J Pharmacol"},{"key":"1103_CR2","doi-asserted-by":"publisher","DOI":"10.35333\/jrp.2020.157","author":"TG Altunta\u015f","year":"2020","unstructured":"Altunta\u015f TG, Baydar A, Kili\u00e7-Kurt Z, Acar C, Sarialtin SY, \u00c7oban T (2020) Novel piperazine substituted indole derivatives: synthesis, anti-inflammatory and antioxidant activities and molecular docking. J Res Pharm. https:\/\/doi.org\/10.35333\/jrp.2020.157","journal-title":"J Res Pharm"},{"key":"1103_CR3","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/5276130","author":"P Arulselvan","year":"2016","unstructured":"Arulselvan P, Fard MT, Tan WS, Gothai S, Fakurazi S, Norhaizan ME, Kumar SS (2016) Role of antioxidants and natural products in inflammation. Oxid Med Cell Longev. https:\/\/doi.org\/10.1155\/2016\/5276130","journal-title":"Oxid Med Cell Longev"},{"issue":"2012","key":"1103_CR4","doi-asserted-by":"publisher","first-page":"9451","DOI":"10.3390\/molecules17089451","volume":"17","author":"C Barea","year":"2012","unstructured":"Barea C, Pab\u00f3n A, Galiano S, P\u00e9rez-Silanes S, Gonzalez G, Deyssard C, Monge A, Deharo E, Aldana I (2012) Antiplasmodial and leishmanicidal activities of 2-cyano-3-(4-phenylpiperazine-1-carboxamido) quinoxaline 1,4-dioxide derivatives. Molecules 17(2012):9451\u20139461","journal-title":"Molecules"},{"issue":"1","key":"1103_CR5","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1007\/s10787-017-0390-8","volume":"26","author":"DC Batista","year":"2018","unstructured":"Batista DC, Silva DPB, Florentino IF, Cardoso CS, Gon\u00e7alves MP, Valadares MC, Li\u00e3o LM, Sanz G, Vaz BG, Costa EA, Menegatti R (2018) Anti-inflammatory effect of a new piperazine derivative: (4-methylpiperazin-1-yl)(1-phenyl-1H-pyrazol-4-yl)methanone. Inflammopharmacology 26(1):217\u2013226. https:\/\/doi.org\/10.1007\/s10787-017-0390-8 (Epub 2017 Aug 20 PMID: 28825161)","journal-title":"Inflammopharmacology"},{"issue":"4","key":"1103_CR6","doi-asserted-by":"publisher","first-page":"877","DOI":"10.1007\/s10787-020-00685-8","volume":"28","author":"CS Cardoso","year":"2020","unstructured":"Cardoso CS, Silva DPB, Silva DM, Florentino IF, Fajemiroye JO, Moreira LKS, Vasconcelos JP, Sanz G, Vaz BG, Li\u00e3o LM, Lima DDS, Dos Santos FCA, Menegatti R, Costa EA (2020) Mechanisms involved in the antinociceptive and anti-inflammatory effects of a new triazole derivative: 5-[1-(4-fluorophenyl)-1H-1,2,3-triazol-4-yl]-1H-tetrazole (LQFM-096). Inflammopharmacology 28(4):877\u2013892. https:\/\/doi.org\/10.1007\/s10787-020-00685-8","journal-title":"Inflammopharmacology"},{"key":"1103_CR7","first-page":"137","volume":"11","author":"TP Cera","year":"2012","unstructured":"Cera TP, Pancote CG (2012) Planejamento de F\u00e1rmacos. Revista Cient\u00edfica Unilago 11:137\u2013148","journal-title":"Revista Cient\u00edfica Unilago"},{"issue":"2012","key":"1103_CR8","doi-asserted-by":"publisher","first-page":"2434","DOI":"10.1016\/j.bmcl.2012.02.023","volume":"22","author":"E Chae","year":"2012","unstructured":"Chae E, Yi H, Choi Y, Cho H, Lee K, Moon H (2012) Synthesis and pharmacological evaluation of carbamic acid 1-phenyl-3-(4-phenyl-piperazine-1-yl)-propyl ester derivatives as new analgesic agents. Bioorg Med Chem Lett 22(2012):2434\u20132439","journal-title":"Bioorg Med Chem Lett"},{"key":"1103_CR9","doi-asserted-by":"publisher","DOI":"10.1016\/s0223-5234(03)00115-6","author":"C Charlier","year":"2003","unstructured":"Charlier C, Michaux C (2003) Dual inhibition of cyclooxygenase-2 (COX-2) and 5-lipoxygenase (5-LOX) as a new strategy to provide safer non-steroidal anti-inflammatory drugs. Eur J Med Chem. https:\/\/doi.org\/10.1016\/s0223-5234(03)00115-6","journal-title":"Eur J Med Chem"},{"issue":"2011","key":"1103_CR10","doi-asserted-by":"publisher","first-page":"5785","DOI":"10.3390\/molecules16075785","volume":"16","author":"Y Chen","year":"2011","unstructured":"Chen Y, Wang G, Xu X, Liu BF, Li J, Zhang G (2011) Design, synthesis and biological activity evaluation of arylpiperazine derivatives for the treatment of neuropathic pain. Molecules 16(2011):5785\u20135806","journal-title":"Molecules"},{"issue":"1","key":"1103_CR11","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1016\/j.clim.2004.05.008","volume":"113","author":"R Di Paola","year":"2004","unstructured":"Di Paola R, Di Marco R, Mazzon E, Genovese T, Bendtzen K, Macri B, Nicoletti F, Cuzzocrea S (2004) Prevention of carrageenan-induced pleurisy in mice by anti-CD30 ligand monoclonal antibody. Clin Immunol 113(1):64\u201373. https:\/\/doi.org\/10.1016\/j.clim.2004.05.008","journal-title":"Clin Immunol"},{"key":"1103_CR12","doi-asserted-by":"publisher","unstructured":"Dzoyem JP, McGaw LJ, Kuete V, Bakowsky U (2017) Chapter 9 - anti-inflammatory and anti-nociceptive activities of African medicinal spices and vegetables. In: Victor K (ed) Medicinal spices and vegetables from Africa. Academic Press, p 239\u2013270. https:\/\/doi.org\/10.1016\/B978-0-12-809286-6.00009-1.","DOI":"10.1016\/B978-0-12-809286-6.00009-1"},{"issue":"11","key":"1103_CR13","doi-asserted-by":"publisher","first-page":"1433","DOI":"10.1016\/s0006-2952(01)00747-x","volume":"62","author":"S Fiorucci","year":"2001","unstructured":"Fiorucci S, Meli R, Bucci M, Cirino G (2001) Dual inhibitors of cyclooxygenase and 5-lipoxygenase. A new avenue in anti-inflammatory therapy? Biochem Pharmacol 62(11):1433\u20131438. https:\/\/doi.org\/10.1016\/s0006-2952(01)00747-x","journal-title":"Biochem Pharmacol"},{"issue":"3","key":"1103_CR14","doi-asserted-by":"publisher","first-page":"987","DOI":"10.1590\/S0001-37652013000300011","volume":"85","author":"IF Florentino","year":"2013","unstructured":"Florentino IF, Nascimento MV, Galdino PM, De Brito AF, Da Rocha FF, Tonussi CR, De Lima TC, De Paula JR, Costa EA (2013) Evaluation of analgesic and anti-inflammatory activities of Hydrocotyle umbellata L., Araliaceae (acari\u00e7oba) in mice. An Acad Bras Cienc 85(3):987\u2013997. https:\/\/doi.org\/10.1590\/S0001-37652013000300011","journal-title":"An Acad Bras Cienc"},{"key":"1103_CR15","doi-asserted-by":"publisher","first-page":"106893","DOI":"10.1016\/j.intimp.2020.106893","volume":"88","author":"GM Galv\u00e3o","year":"2020","unstructured":"Galv\u00e3o GM, Florentino IF, Sanz G, Vaz BG, Li\u00e3o LM, Sabino JR, Cardoso CS, da Silva DPB, Costa EA, Silva ALP, da Silva ACG, Valadares MC, Leite JA, de S Gil E, Menegatti R (2020) Anti-inflammatory and antinociceptive activity profile of a new lead compound - LQFM219. Int Immunopharmacol 88:106893. https:\/\/doi.org\/10.1016\/j.intimp.2020.106893","journal-title":"Int Immunopharmacol"},{"issue":"4","key":"1103_CR16","doi-asserted-by":"publisher","first-page":"348","DOI":"10.4103\/0976-500X.103699.PMID:23326113;PMCID:PMC3543562","volume":"3","author":"SP Gawade","year":"2012","unstructured":"Gawade SP (2012) Acetic acid induced painful endogenous infliction in writhing test on mice. J Pharmacol Pharmacother 3(4):348. https:\/\/doi.org\/10.4103\/0976-500X.103699.PMID:23326113;PMCID:PMC3543562","journal-title":"J Pharmacol Pharmacother"},{"issue":"6","key":"1103_CR17","doi-asserted-by":"publisher","first-page":"472","DOI":"10.3390\/80600472","volume":"8","author":"A Geronikaki","year":"2003","unstructured":"Geronikaki A, Hadjipavlou-Litina D, Chatziopoulos C, Soloupis G (2003) Synthesis and biological evaluation of new 4,5-disubstituted-thiazolyl amides, derivatives of 4-hydroxy-piperidine or of 4-n-methyl piperazine. Molecules 8(6):472\u2013479. https:\/\/doi.org\/10.3390\/80600472","journal-title":"Molecules"},{"key":"1103_CR18","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/536962","author":"R Ghosh","year":"2015","unstructured":"Ghosh R, Alajbegovic A, Gomes AV (2015) NSAIDs and cardiovascular diseases: role of reactive oxygen species. Oxid Med Cell Longev. https:\/\/doi.org\/10.1155\/2015\/536962","journal-title":"Oxid Med Cell Longev"},{"key":"1103_CR19","doi-asserted-by":"publisher","DOI":"10.1111\/jfbc.13880","author":"CCF Gomes","year":"2021","unstructured":"Gomes CCF, Oliveira LS, Rodrigues DC, Ribeiro PRV, Canuto KM, Duarte ASG, E\u00e7a KS, de Figueiredo RW (2021) Evidence for antioxidant and anti-inflammatory potential of mango (Mangifera indica L.) in naproxen-induced gastric lesions in rat. J Food Biochem. https:\/\/doi.org\/10.1111\/jfbc.13880","journal-title":"J Food Biochem"},{"key":"1103_CR20","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpain.2013.06.008","author":"N Gregory","year":"2013","unstructured":"Gregory N, Harris AL, Robinson CR, Dougherty PM, Fuchs PN, Sluka KA (2013) An overview of animal models of pain: disease models and outcome measures. J Pain. https:\/\/doi.org\/10.1016\/j.jpain.2013.06.008","journal-title":"J Pain"},{"issue":"3","key":"1103_CR21","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1258\/acb.2011.010249","volume":"50","author":"A Hasmann","year":"2013","unstructured":"Hasmann A, Wehrsch\u00fctz-sigl E, Marold A, Wiesbauer H, Schoeftner R, Gewe\u00dfler U, Guebitz GM (2013) Analysis of myeloperoxidase activity in wound fluids as a marker of infection. Ann Clin Biochem 50(3):245\u2013254. https:\/\/doi.org\/10.1258\/acb.2011.010249","journal-title":"Ann Clin Biochem"},{"issue":"1","key":"1103_CR22","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1016\/j.clim.2004.05.008","volume":"66","author":"GA Higgs","year":"1980","unstructured":"Higgs GA, Eakins KE, Mugridge KG, Moncada S, Vane JR (1980) The effects of non steroid anti-inflammatory drugs on leukocyte migration in carrageenin-induced inflammation. Eur J Pharmacol 66(1):81\u201386. https:\/\/doi.org\/10.1016\/j.clim.2004.05.008","journal-title":"Eur J Pharmacol"},{"issue":"1","key":"1103_CR23","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1016\/0304-3959(87)90088-1","volume":"30","author":"S Hunskaar","year":"1987","unstructured":"Hunskaar S, Hole K (1987) The formalin test in mice: dissociation between inflammatory and non-inflammatory pain. Pain 30(1):103\u2013114. https:\/\/doi.org\/10.1016\/0304-3959(87)90088-1","journal-title":"Pain"},{"issue":"2","key":"1103_CR24","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1055\/a-1323-2813","volume":"71","author":"A Jain","year":"2021","unstructured":"Jain A, Chaudhary J, Khaira H, Chopra B, Dhingra A (2021) Piperazine: a promising scaffold with analgesic and anti-inflammatory potential. Drug Res (stuttg) 71(2):62\u201372. https:\/\/doi.org\/10.1055\/a-1323-2813 (Epub 2020 Dec 17 PMID: 33336346)","journal-title":"Drug Res (stuttg)"},{"issue":"1","key":"1103_CR25","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1016\/j.molimm.2012.10.027","volume":"54","author":"LI Jiang","year":"2013","unstructured":"Jiang LI, Sternweis PC, Wang JE (2013) Zymosan activates protein kinase A via adenylyl cyclase VII to modulate innate immune responses during inflammation. Mol Immunol 54(1):14\u201322. https:\/\/doi.org\/10.1016\/j.molimm.2012.10.027","journal-title":"Mol Immunol"},{"issue":"19","key":"1103_CR26","doi-asserted-by":"publisher","first-page":"5915","DOI":"10.1021\/jm800935u","volume":"51","author":"J Jin","year":"2008","unstructured":"Jin J, Budzik B, Wang Y, Shi D, Wang F, Xie H, Wan Z, Zhu C, Foley JJ, Webb EF, Berlanga M, Burman M, Sarau HM, Morrow DM, Moore ML, Rivero RA, Palovich M, Salmon M, Belmonte KE, Lain\u00e9 DI (2008) Discovery of biphenyl piperazines as novel and long acting muscarinic acetylcholine receptor antagonists. J Med Chem 51(19):5915\u20135918. https:\/\/doi.org\/10.1021\/jm800935u (Epub 2008 Sep 18 PMID: 18798607)","journal-title":"J Med Chem"},{"key":"1103_CR27","first-page":"1","volume":"21","author":"L Jingfen","year":"2016","unstructured":"Jingfen L, Yong Y, Lisheng W et al (2016) Synthesis, characterization, and anti-inflammatory activities of methyl salicylate derivatives bearing piperazine moiety. Molecules 21:1\u201311","journal-title":"Molecules"},{"key":"1103_CR28","doi-asserted-by":"publisher","first-page":"633","DOI":"10.2174\/1389557043403747","volume":"4","author":"F Jul\u00e9mont","year":"2004","unstructured":"Jul\u00e9mont F, Dogn\u00e9 JM, Pirotte B, de Leval X (2004) Recent development in the field of dual COX \/ 5-LOX inhibitors. Mini Rev Med Chem 4:633\u2013638","journal-title":"Mini Rev Med Chem"},{"issue":"4","key":"1103_CR29","doi-asserted-by":"publisher","first-page":"1096","DOI":"10.1111\/j.1476-5381.1992.tb13413.x","volume":"107","author":"A Kawabata","year":"1992","unstructured":"Kawabata A, Nishimura Y, Takagi H (1992) L-leucyl-L-arginine, naltrindole and D-arginine block antinociception elicited by L-arginine in mice with carrageenin-induced hyperalgesia. Br J Pharmacol 107(4):1096\u20131101. https:\/\/doi.org\/10.1111\/j.1476-5381.1992.tb13413.x","journal-title":"Br J Pharmacol"},{"issue":"27","key":"1103_CR30","doi-asserted-by":"publisher","first-page":"1610136","DOI":"10.3389\/pore.2021.1610136.PMID:35058736;PMCID:PMC8763665","volume":"4","author":"AL Kiss","year":"2022","unstructured":"Kiss AL (2022) Inflammation in focus: the beginning and the end. Pathol Oncol Res 4(27):1610136. https:\/\/doi.org\/10.3389\/pore.2021.1610136.PMID:35058736;PMCID:PMC8763665","journal-title":"Pathol Oncol Res"},{"key":"1103_CR31","first-page":"412","volume":"18","author":"R Koster","year":"1959","unstructured":"Koster R, Anderson M, Beer ED (1959) Acetic acid for analgesic screening. Fed Proc 18:412\u2013421","journal-title":"Fed Proc"},{"issue":"83","key":"1103_CR32","doi-asserted-by":"publisher","first-page":"534","DOI":"10.1016\/j.ejmech.2014.06.032","volume":"18","author":"D \u0141a\u017cewska","year":"2014","unstructured":"\u0141a\u017cewska D, Wi\u0119cek M, Ner J, Kami\u0144ska K, Kottke T, Schwed JS, Zygmunt M, Karcz T, Olejarz A, Kuder K, Latacz G, Grosicki M, Sapa J, Karolak-Wojciechowska J, Stark H, Kie\u0107-Kononowicz K (2014) Aryl-1,3,5-triazine derivatives as histamine H4 receptor ligands. Eur J Med Chem 18(83):534\u2013546. https:\/\/doi.org\/10.1016\/j.ejmech.2014.06.032 (Epub 2014 Jun 17 PMID: 24996140)","journal-title":"Eur J Med Chem"},{"issue":"11","key":"1103_CR33","doi-asserted-by":"publisher","first-page":"1544","DOI":"10.3390\/molecules21111544.PMID:27886112;PMCID:PMC6273818","volume":"21","author":"J Li","year":"2016","unstructured":"Li J, Yin Y, Wang L, Liang P, Li M, Liu X, Wu L, Yang H (2016) Synthesis, characterization, and anti-inflammatory activities of methyl salicylate derivatives bearing piperazine moiety. Molecules 21(11):1544. https:\/\/doi.org\/10.3390\/molecules21111544.PMID:27886112;PMCID:PMC6273818","journal-title":"Molecules"},{"key":"1103_CR34","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1111\/j.2042-7158.2012.01582.x","volume":"65","author":"RC Lino","year":"2012","unstructured":"Lino RC, Martins FI, Florentino IF, Nascimento MVM, Galdino PM, Andrade CH et al (2012) Anti-inflammatory effect of (E)-4-(3,7-dimethylocta-2, 6-dienylamino)phenol, a new derivative of 4-nerolidylcatechol. J Pharm Pharmacol 65:133\u2013141","journal-title":"J Pharm Pharmacol"},{"key":"1103_CR35","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1111\/j.2042-7158.2012.01582.x","volume":"65","author":"RC Lino","year":"2013","unstructured":"Lino RC, Martins FI, Florentino IF, Nascimento MVM, Galdino PM, Andrade CH, Rezende KR, Menegatti R, Costa EA (2013) Anti-inflammatory effect of (E)-4-(3,7-dimethylocta-2,6-dienylamino)phenol, a new derivative of 4-nerolidylcatechol. J Pharm Pharmacol 65:133\u2013141. https:\/\/doi.org\/10.1111\/j.2042-7158.2012.01582.x","journal-title":"J Pharm Pharmacol"},{"key":"1103_CR36","doi-asserted-by":"publisher","unstructured":"Mittal M, Siddiqui MR, Tran K, Reddy SP, Malik AB. Reactive oxygen species in inflammation and tissue injury. Antioxid Redox Signal. 2014 20(7):1126\u201367. doi: https:\/\/doi.org\/10.1089\/ars.2012.5149.","DOI":"10.1089\/ars.2012.5149"},{"key":"1103_CR37","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1016\/j.ejphar.2007.07.062","volume":"575","author":"G Munron","year":"2007","unstructured":"Munron G (2007) Dopamine D(1) and D(2) receptor agonism enhances antinociception mediated by the serotonin and noradrenaline reuptake inhibitor duloxetine in the rat formalin test. Eur J Pharmacol 575:66\u201374","journal-title":"Eur J Pharmacol"},{"issue":"8","key":"1103_CR38","doi-asserted-by":"publisher","first-page":"791","DOI":"10.1016\/j.lfs.2006.02.026","volume":"79","author":"S Pieretti","year":"2006","unstructured":"Pieretti S, Dominici L, Di Giannuario A, Cesari N, Piaz VD (2006) Local anti-inflammatory effect and behavioral studies on new PDE4 inhibitors. Life Sci 79(8):791\u2013800. https:\/\/doi.org\/10.1016\/j.lfs.2006.02.026","journal-title":"Life Sci"},{"issue":"12","key":"1103_CR39","doi-asserted-by":"publisher","first-page":"174480691664167","DOI":"10.1177\/1744806916641678.PMID:27053601;PMCID:PMC4956396","volume":"6","author":"Z Pudukulatham","year":"2016","unstructured":"Pudukulatham Z, Zhang FX, Gadotti VM, M\u2019Dahoma S, Swami P, Tamboli Y, Zamponi GW (2016) Synthesis and characterization of a disubstituted piperazine derivative with T-type channel blocking action and analgesic properties. Mol Pain 6(12):1744806916641678. https:\/\/doi.org\/10.1177\/1744806916641678.PMID:27053601;PMCID:PMC4956396","journal-title":"Mol Pain"},{"key":"1103_CR40","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1016\/S0014-2999(99)00790-6","volume":"387","author":"RA Ribeiro","year":"2000","unstructured":"Ribeiro RA, Vale M, Thomazzi SM, Paschoalato AB, Poole S, Ferreira SH, Cunha FQ (2000) Involvement of resident macrophages and mast cells in the writhing nociceptive response induced by zymosan and acetic acid in mice. Eur J Pharmacol 387:111\u2013118","journal-title":"Eur J Pharmacol"},{"issue":"12","key":"1103_CR41","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1016\/j.bjae.2018.09.003","volume":"18","author":"J Royds","year":"2018","unstructured":"Royds J, McCrory C (2018) Neuroimmunity and chronic pain. BJA Educ 18(12):377\u2013383","journal-title":"BJA Educ"},{"issue":"2013","key":"1103_CR42","first-page":"622","volume":"5","author":"EX She","year":"2013","unstructured":"She EX, Hao Z (2013) A novel piperazine derivative potently induces caspase-dependent apoptosis of cancer cells via inhibition of multiple cancer signaling pathways. Am J Transl Res 5(2013):622\u2013633","journal-title":"Am J Transl Res"},{"key":"1103_CR43","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1016\/j.pbb.2015.08.008","volume":"137","author":"DP Silva","year":"2015","unstructured":"Silva DP, Florentino IF, Oliveira LP, Lino RC, Galdino PM, Menegatti R, Costa EA (2015) Anti-nociceptive and anti-inflammatory activities of 4-[(1-phenyl-1H-pyrazol-4-yl) methyl] 1-piperazine carboxylic acid ethyl ester: a new piperazine derivative. Pharmacol Biochem Behav 137:86\u201392. https:\/\/doi.org\/10.1016\/j.pbb.2015.08.008","journal-title":"Pharmacol Biochem Behav"},{"issue":"5","key":"1103_CR44","doi-asserted-by":"publisher","first-page":"1189","DOI":"10.1007\/s10787-018-0516-7","volume":"26","author":"DPB Silva","year":"2018","unstructured":"Silva DPB, Florentino IF, da Silva DM, Lino RC, Cardoso CS, Moreira LKS, Vasconcelos GA, Vinhal DC, Cardoso ACD, Villavicencio B, Verli H, Vaz BG, Li\u00e3o LM, da Cunha LC, Menegatti R, Costa EA (2018a) Molecular docking and pharmacological\/toxicological assessment of a new compound designed from celecoxib and paracetamol by molecular hybridization. Inflammopharmacology 26(5):1189\u20131206. https:\/\/doi.org\/10.1007\/s10787-018-0516-7 (Epub 2018 Jul 23 PMID: 30039481)","journal-title":"Inflammopharmacology"},{"key":"1103_CR45","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1016\/j.jep.2017.11.021","volume":"213","author":"DPB Silva","year":"2018","unstructured":"Silva DPB, Florentino IF, da Silva Moreira LK, Brito AF, Carvalho VV, Rodrigues MF, Vasconcelos GA, Vaz BG, Pereira-Junior MA, Fernandes KF, Costa EA (2018b) Chemical characterization and pharmacological assessment of polysaccharide free, standardized cashew gum extract (Anacardium occidentale L.). J Ethnopharmacol 213:395\u2013402. https:\/\/doi.org\/10.1016\/j.jep.2017.11.021","journal-title":"J Ethnopharmacol"},{"issue":"3","key":"1103_CR46","doi-asserted-by":"publisher","first-page":"1072","DOI":"10.1124\/jpet.103.057489","volume":"307","author":"K Takeshita","year":"2003","unstructured":"Takeshita K, Sakai K, Bacon KB, Gantner F (2003) Critical role of histamine H4 receptor in leukotriene B4 production and mast cell-dependent neutrophil recruitment induced by zymosan in vivo. J Pharmacol Exp Ther 307(3):1072\u20131078. https:\/\/doi.org\/10.1124\/jpet.103.057489","journal-title":"J Pharmacol Exp Ther"},{"issue":"1","key":"1103_CR47","doi-asserted-by":"publisher","first-page":"272","DOI":"10.1124\/jpet.103.063776","volume":"310","author":"K Takeshita","year":"2004","unstructured":"Takeshita K, Bacon KB, Gantner F (2004) Critical role of L-selectin and histamine H4 receptor in zymosan-induced neutrophil recruitment from the bone marrow: comparison with carrageenan. J Pharmacol Exp Ther 310(1):272\u2013280. https:\/\/doi.org\/10.1124\/jpet.103.063776","journal-title":"J Pharmacol Exp Ther"},{"issue":"1","key":"1103_CR48","doi-asserted-by":"publisher","first-page":"404","DOI":"10.1124\/jpet.103.061754","volume":"309","author":"RL Thurmond","year":"2004","unstructured":"Thurmond RL, Desai PJ, Dunford PJ, Fung-Leung WP, Hofstra CL, Jiang W, Nguyen S, Riley JP, Sun S, Williams KN, Edwards JP, Karlsson L (2004) A potent and selective histamine H4 receptor antagonist with anti-inflammatory properties. J Pharmacol Exp Ther 309(1):404\u2013413. https:\/\/doi.org\/10.1124\/jpet.103.061754 (Epub 2004 Jan 13)","journal-title":"J Pharmacol Exp Ther"},{"issue":"4","key":"1103_CR49","first-page":"655","volume":"10","author":"A Zarghi","year":"2011","unstructured":"Zarghi A, Arfaei S (2011) Selective COX-2 inhibitors: a review of their structure-activity relationships. Iran J Pharm Res 10(4):655\u2013683","journal-title":"Iran J Pharm Res"},{"issue":"1","key":"1103_CR50","doi-asserted-by":"publisher","first-page":"1165","DOI":"10.1080\/14756366.2021.1931861.PMID:34080510;PMCID:PMC8183565","volume":"36","author":"RH Zhang","year":"2021","unstructured":"Zhang RH, Guo HY, Deng H, Li J, Quan ZS (2021) Piperazine skeleton in the structural modification of natural products: a review. J Enzyme Inhib Med Chem 36(1):1165\u20131197. https:\/\/doi.org\/10.1080\/14756366.2021.1931861.PMID:34080510;PMCID:PMC8183565","journal-title":"J Enzyme Inhib Med Chem"}],"container-title":["Inflammopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10787-022-01103-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10787-022-01103-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10787-022-01103-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,24]],"date-time":"2023-02-24T04:36:07Z","timestamp":1677213367000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10787-022-01103-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11,29]]},"references-count":50,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2023,2]]}},"alternative-id":["1103"],"URL":"https:\/\/doi.org\/10.1007\/s10787-022-01103-x","relation":{},"ISSN":["0925-4692","1568-5608"],"issn-type":[{"value":"0925-4692","type":"print"},{"value":"1568-5608","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,11,29]]},"assertion":[{"value":"21 August 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 November 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 November 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no conflicts of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"Animal handling was performed according to the experimental protocols approved by the Ethics Committee on Animal Use (CEUA No. 093\/19) of UFG.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}]}}