{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T15:40:36Z","timestamp":1786981236989,"version":"build-2736575974"},"reference-count":49,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2022,12,21]],"date-time":"2022-12-21T00:00:00Z","timestamp":1671580800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2022,12,21]],"date-time":"2022-12-21T00:00:00Z","timestamp":1671580800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100002386","name":"Cairo University","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100002386","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Inflammopharmacol"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Plant resins or oleoresins comprise a chemically complex mixture of different classes of compounds. Oleoresin of the genus\n                    <jats:italic>Araucaria<\/jats:italic>\n                    combines essential oil (EO) and resin. It possesses gastroprotective, cytotoxic, and timicrobial, antipyretic, and anti-inflammatory activities. The study aimed to investigate the EOs from the oleoresins of two\n                    <jats:italic>Araucaria<\/jats:italic>\n                    species,\n                    <jats:italic>A. bidwillii<\/jats:italic>\n                    and\n                    <jats:italic>A. heterophylla,<\/jats:italic>\n                    chemically and biologically for their gastroprotective, anti-inflammatory, antioxidant, and anti-\n                    <jats:italic>Helicobacter pylori<\/jats:italic>\n                    potentials. The chemical composition of both species cultivated in Egypt was analyzed with GC-MS and compared with those cultivated abroad using principal component analysis (PCA). There were 37 and 17 secondary metabolites identified in\n                    <jats:italic>A. heterophylla<\/jats:italic>\n                    and\n                    <jats:italic>A. bidwillii<\/jats:italic>\n                    , respectively. The EOs of both species showed a pronounced inhibitory effect on Helicobacter pylori activity in vitro. The gastroprotective effect was assessed in vivo using ethanol-induced gastric ulcer model in rats. Inflammatory cytokines, oxidative stress, and the nuclear factor-kappa B (NF-\u03baB) biomarkers were assessed in the stomach tissues. The ulcer index and percentage of ulcer protection were determined. Stomach sections were examined histopathologically by staining with (H\/E) and periodic acid Schiff (PAS). Moreover, the proliferative index was determined using the Ki-67 immunostaining. The treatment of rats with EOs (50, 100, and 200\u00a0mg\/kg, orally) 1\u00a0hour prior to ethanol administration showed promising gastroprotective, anti-inflammatory, and antioxidant potentials. These findings declared the gastroprotective role played by both EOs with the superiority of\n                    <jats:italic>A. bidwillii<\/jats:italic>\n                    over\n                    <jats:italic>A. heterophylla<\/jats:italic>\n                    via modulation of oxidative stress\/NF-\u03baB\/inflammatory cytokines. Their use can be recommended to protect against the recurrence of peptic ulcers.\n                  <\/jats:p>","DOI":"10.1007\/s10787-022-01112-w","type":"journal-article","created":{"date-parts":[[2022,12,21]],"date-time":"2022-12-21T03:03:52Z","timestamp":1671591832000},"page":"465-483","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Gastroprotective and anti-Helicobacter pylori potentials of essential oils from the oleoresins of Araucaria bidwillii and Araucaria heterophylla"],"prefix":"10.1007","volume":"31","author":[{"given":"Dalia E.","family":"Ali","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marwa M.","family":"Abd el-Aziz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sherihan Salaheldin Abdelhamid","family":"Ibrahim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eman","family":"Sheta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0617-1420","authenticated-orcid":false,"given":"Essam","family":"Abdel-Sattar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,12,21]]},"reference":[{"key":"1112_CR1","doi-asserted-by":"publisher","first-page":"2893","DOI":"10.1016\/j.bmcl.2016.04.046","volume":"26","author":"EKA Abdelall","year":"2016","unstructured":"Abdelall EKA, Lamie PF, Ali WAM (2016) Cyclooxygenase-2 and 15-lipoxygenase inhibition, synthesis, anti-inflammatory activity and ulcer liability of new celecoxib analogues: determination of region-specific pyrazole ring formation by NOESY. Bioorg Med Chem Lett 26:2893\u20132899. https:\/\/doi.org\/10.1016\/j.bmcl.2016.04.046","journal-title":"Bioorg Med Chem Lett"},{"key":"1112_CR2","doi-asserted-by":"publisher","first-page":"5833","DOI":"10.3390\/molecules26195833","volume":"26","author":"MF Abdelhameed","year":"2021","unstructured":"Abdelhameed MF, Asaad GF, Ragab TI, Ahmed RF, El Gendy AE-NG, Abd El-Rahman SS et al (2021) Oral and topical anti-inflammatory and antipyretic potentialities of Araucaria bidiwillii shoot essential oil and its nanoemulsion in relation to chemical composition. Molecules 26:5833. https:\/\/doi.org\/10.3390\/molecules26195833","journal-title":"Molecules"},{"key":"1112_CR3","doi-asserted-by":"publisher","first-page":"819","DOI":"10.1515\/znc-2009-11-1211","volume":"64","author":"E Abdel-Sattar","year":"2009","unstructured":"Abdel-Sattar E, Monem ARA, Ezzat SM, El-Halawany AM, Mouneir SM (2009) Chemical and biological investigation of Araucaria heterophylla Salisb. Resin Zeitschrift F\u00fcr Naturforschung C 64:819\u2013823. https:\/\/doi.org\/10.1515\/znc-2009-11-1211","journal-title":"Resin Zeitschrift F\u00fcr Naturforschung C"},{"key":"1112_CR4","volume-title":"Identification of essential oil components by gas chromatography\/mass spectrometry","author":"RP Adams","year":"2007","unstructured":"Adams RP (2007) Identification of essential oil components by gas chromatography\/mass spectrometry, 4th edn. Allured Publishing Corporation, Carol Stream","edition":"4"},{"key":"1112_CR5","doi-asserted-by":"publisher","first-page":"3506207","DOI":"10.1155\/2020\/3506207","volume":"2020","author":"AF Ajayi","year":"2020","unstructured":"Ajayi AF, Olaleye SB (2020) Immunohistochemical studies of age-related changes in cell proliferation and angiogenesis during the healing of acetic acid-induced gastric ulcers in rats. Sci World J 2020:3506207. https:\/\/doi.org\/10.1155\/2020\/3506207","journal-title":"Sci World J"},{"key":"1112_CR6","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0122417","volume":"10","author":"HH Arab","year":"2015","unstructured":"Arab HH, Salama SA, Omar HA, Arafa E-SA, Maghrabi IA (2015) Diosmin protects against ethanol-induced gastric injury in rats: novel anti-ulcer actions. PLoS ONE 10:e0122417. https:\/\/doi.org\/10.1371\/journal.pone.0122417","journal-title":"PLoS ONE"},{"key":"1112_CR7","doi-asserted-by":"publisher","first-page":"651","DOI":"10.4314\/tjpr.v12i4.31","volume":"12","author":"MS Aslam","year":"2013","unstructured":"Aslam MS, Choudhary BA, Uzair M, Ijaz AS (2013) Phytochemical and ethno-pharmacological review of the genus Araucaria\u2013review. Trop J Pharm Res 12:651\u2013659. https:\/\/doi.org\/10.4314\/tjpr.v12i4.31","journal-title":"Trop J Pharm Res"},{"key":"1112_CR8","doi-asserted-by":"publisher","first-page":"554","DOI":"10.1016\/j.biopha.2018.12.002","volume":"110","author":"RS Aziz","year":"2019","unstructured":"Aziz RS, Siddiqua A, Shahzad M, Shabbir A, Naseem N (2019) Oxyresveratrol ameliorates ethanol-induced gastric ulcer via downregulation of IL-6, TNF-\u03b1, NF-\u0138B, and COX-2 levels, and upregulation of TFF-2 levels. Biomed Pharmacother 110:554\u2013560. https:\/\/doi.org\/10.1016\/j.biopha.2018.12.002","journal-title":"Biomed Pharmacother"},{"key":"1112_CR9","doi-asserted-by":"publisher","DOI":"10.1016\/j.btre.2020.e00470","volume":"26","author":"DA Baker","year":"2020","unstructured":"Baker DA (2020) Plants against Helicobacter pylori to combat resistance: an ethnopharmacological review. Biotechnology Reports 26:e00470. https:\/\/doi.org\/10.1016\/j.btre.2020.e00470","journal-title":"Biotechnology Reports"},{"key":"1112_CR10","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1186\/1472-6882-9-2","volume":"9","author":"C Bonacorsi","year":"2009","unstructured":"Bonacorsi C, Raddi MSG, Carlos IZ, Sannomiya M, Vilegas W (2009) Anti-Helicobacter pylori activity and immunostimulatory effect of extracts from Byrsonima crassa Nied. (Malpighiaceae). BMC Complement Altern Med 9:2. https:\/\/doi.org\/10.1186\/1472-6882-9-2","journal-title":"BMC Complement Altern Med"},{"key":"1112_CR11","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0201561","volume":"13","author":"SA Brito","year":"2018","unstructured":"Brito SA, Barbosa IS, de Almeida CL, de Medeiros JW, Silva Neto JC, Rolim LA et al (2018) Evaluation of gastroprotective and ulcer healing activities of yellow mombin juice from Spondias mombin L. PLoS ONE 13:e0201561. https:\/\/doi.org\/10.1371\/journal.pone.0201561","journal-title":"PLoS ONE"},{"key":"1112_CR12","doi-asserted-by":"publisher","first-page":"6810369","DOI":"10.1155\/2018\/6810369","volume":"2018","author":"X Chen","year":"2018","unstructured":"Chen X, Hu L, Wu H, Liu W, Chen S, Zhou A et al (2018) Anti-<i>Helicobacter pylori<\/i> and anti-inflammatory effects and constituent analysis of modified xiaochaihutang for the treatment of chronic gastritis and gastric ulcer. Evid-Based Complement Altern Med 2018:6810369. https:\/\/doi.org\/10.1155\/2018\/6810369","journal-title":"Evid-Based Complement Altern Med"},{"key":"1112_CR13","doi-asserted-by":"publisher","first-page":"255","DOI":"10.26538\/tjnpr\/v4i7.1","volume":"4","author":"AR de Ali","year":"2020","unstructured":"de Ali AR, El Gedaily RA, Ezzat SM, Meselhy MR, Abdel-Sattar E (2020) Evaluation of the anti-inflammatory and antioxidant activities of selected resin exudates. Trop J Nat Prod Res 4:255\u2013261. https:\/\/doi.org\/10.26538\/tjnpr\/v4i7.1","journal-title":"Trop J Nat Prod Res"},{"key":"1112_CR14","doi-asserted-by":"publisher","first-page":"1230","DOI":"10.1111\/j.2042-7158.2011.01321.x","volume":"63","author":"AP de Oliveira","year":"2011","unstructured":"de Oliveira AP, Santin JR, Lemos M, Klein J\u00fanior LC, Couto AG, da Silva Bittencourt CM et al (2011) Gastroprotective activity of methanol extract and marrubiin obtained from leaves of Marrubium vulgare L.(Lamiaceae). J Pharm Pharmacol 63:1230\u20131237. https:\/\/doi.org\/10.1111\/j.2042-7158.2011.01321.x","journal-title":"J Pharm Pharmacol"},{"key":"1112_CR15","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1080\/07391102.2021.1885494","volume":"40","author":"SS El-Hawary","year":"2021","unstructured":"El-Hawary SS, Rabeh MA, Raey MAE, El-Kadder EMA, Sobeh M, Abdelmohsen UR et al (2021) Metabolomic profiling of three Araucaria species, and their possible potential role against COVID-19. J Biomol Struct Dyn 40:1\u201313. https:\/\/doi.org\/10.1080\/07391102.2021.1885494","journal-title":"J Biomol Struct Dyn"},{"key":"1112_CR16","doi-asserted-by":"publisher","first-page":"188","DOI":"10.1016\/j.indcrop.2018.03.051","volume":"118","author":"WM Elkady","year":"2018","unstructured":"Elkady WM, Ayoub IM (2018) Chemical profiling and antiproliferative effect of essential oils of two Araucaria species cultivated in Egypt. Ind Crops Prod 118:188\u2013195. https:\/\/doi.org\/10.1016\/j.indcrop.2018.03.051","journal-title":"Ind Crops Prod"},{"key":"1112_CR17","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1016\/j.cbi.2015.01.015","volume":"229","author":"SA El-Maraghy","year":"2015","unstructured":"El-Maraghy SA, Rizk SM, Shahin NN (2015) Gastroprotective effect of crocin in ethanol-induced gastric injury in rats. Chem Biol Interact 229:26\u201335. https:\/\/doi.org\/10.1016\/j.cbi.2015.01.015","journal-title":"Chem Biol Interact"},{"key":"1112_CR18","doi-asserted-by":"publisher","DOI":"10.1016\/j.indcrop.2020.112272","volume":"148","author":"AI Elshamy","year":"2020","unstructured":"Elshamy AI, Ammar NM, Hassan HA, Al-Rowaily SL, Ragab TI, El Gendy AE-NG et al (2020a) Essential oil and its nanoemulsion of Araucaria heterophylla resin: chemical characterization, anti-inflammatory, and antipyretic activities. Ind Crops Prod 148:112272. https:\/\/doi.org\/10.1016\/j.indcrop.2020.112272","journal-title":"Ind Crops Prod"},{"key":"1112_CR19","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1007\/s00044-019-02465-8","volume":"29","author":"AI Elshamy","year":"2020","unstructured":"Elshamy AI, Farrag A-RH, Mohamed SH, Ali NA, Mohamed TA, Menshawy MM et al (2020b) Gastroprotective effects of ursolic acid isolated from Ochrosia elliptica on ethanol-induced gastric ulcer in rats. Med Chem Res 29:113\u2013125. https:\/\/doi.org\/10.1007\/s00044-019-02465-8","journal-title":"Med Chem Res"},{"key":"1112_CR20","doi-asserted-by":"publisher","first-page":"888","DOI":"10.3390\/plants9070888","volume":"9","author":"C Frezza","year":"2020","unstructured":"Frezza C, Venditti A, De Vita D, Toniolo C, Franceschin M, Ventrone A et al (2020) Phytochemistry, chemotaxonomy, and biological activities of the Araucariaceae family\u2014a review. Plants 9:888. https:\/\/doi.org\/10.3390\/plants9070888","journal-title":"Plants"},{"key":"1112_CR21","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2022.108673","author":"Y-H Fu","year":"2022","unstructured":"Fu Y-H, Duan Y-Z, Sun X-Y, Chen S-Q (2022) Gastroprotective effect of an active ingredients group of Lindera reflexa Hemsl on ethanol-induced gastric ulcers in rats: involvement of VEGFR2\/ERK and TLR-2\/Myd88 signaling pathway. Int Immunopharmacol. https:\/\/doi.org\/10.1016\/j.intimp.2022.108673","journal-title":"Int Immunopharmacol"},{"key":"1112_CR22","doi-asserted-by":"publisher","first-page":"763","DOI":"10.3390\/nu10060763","volume":"10","author":"O Guzm\u00e1n-G\u00f3mez","year":"2018","unstructured":"Guzm\u00e1n-G\u00f3mez O, Garc\u00eda-Rodr\u00edguez RV, Quevedo-Corona L, P\u00e9rez-Past\u00e9n-Borja R, Rivero-Ram\u00edrez NL, R\u00edos-Castro E et al (2018) Amelioration of ethanol-induced gastric ulcers in rats pretreated with phycobiliproteins of Arthrospira (Spirulina) Maxima. Nutrients 10:763. https:\/\/doi.org\/10.3390\/nu10060763","journal-title":"Nutrients"},{"key":"1112_CR23","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2020.110578","volume":"130","author":"EBA J\u00fanior","year":"2020","unstructured":"J\u00fanior EBA, de Oliveira Formiga R, de Lima Serafim CA, Araruna MEC, de Souza Pessoa ML, Vasconcelos RC et al (2020) Estragole prevents gastric ulcers via cytoprotective, antioxidant and immunoregulatory mechanisms in animal models. Biomed Pharmacother 130:110578. https:\/\/doi.org\/10.1016\/j.biopha.2020.110578","journal-title":"Biomed Pharmacother"},{"key":"1112_CR24","doi-asserted-by":"publisher","first-page":"586","DOI":"10.3390\/molecules25030586","volume":"25","author":"I Korona-Glowniak","year":"2020","unstructured":"Korona-Glowniak I, Glowniak-Lipa A, Ludwiczuk A, Baj T, Malm A (2020) The in vitro activity of essential oils against Helicobacter pylori growth and urease activity. Molecules (basel, Switzerland) 25:586. https:\/\/doi.org\/10.3390\/molecules25030586","journal-title":"Molecules (basel, Switzerland)"},{"key":"1112_CR25","doi-asserted-by":"publisher","first-page":"179","DOI":"10.3390\/jcm8020179","volume":"8","author":"L Kuna","year":"2019","unstructured":"Kuna L, Jakab J, Smolic R, Raguz-Lucic N, Vcev A, Smolic M (2019) Peptic ulcer disease: a brief review of conventional therapy and herbal treatment options. J Clin Med 8:179. https:\/\/doi.org\/10.3390\/jcm8020179","journal-title":"J Clin Med"},{"key":"1112_CR26","doi-asserted-by":"publisher","first-page":"11985","DOI":"10.3390\/ijms222111985","volume":"22","author":"W-S Li","year":"2021","unstructured":"Li W-S, Lin S-C, Chu C-H, Chang Y-K, Zhang X, Lin C-C et al (2021) The gastroprotective effect of naringenin against ethanol-induced gastric ulcers in mice through inhibiting oxidative and inflammatory responses. Int J Mol Sci 22:11985. https:\/\/doi.org\/10.3390\/ijms222111985","journal-title":"Int J Mol Sci"},{"key":"1112_CR27","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1016\/S0254-6272(17)30027-4","volume":"37","author":"Z Memariani","year":"2017","unstructured":"Memariani Z, Sharifzadeh M, Bozorgi M, Hajimahmoodi M, Farzaei MH, Gholami M et al (2017) Protective effect of essential oil of Pistacia atlantica Desf. on peptic ulcer: role of \u03b1-pinene. J Tradit Chin Med 37:57\u201363. https:\/\/doi.org\/10.1016\/S0254-6272(17)30027-4","journal-title":"J Tradit Chin Med"},{"key":"1112_CR28","first-page":"1","volume":"1","author":"O Ode","year":"2011","unstructured":"Ode O, Asuzu O (2011) Investigation of cassia singueana leaf extract for antiulcer effects using ethanol-induced gastric ulcer model in rats. Int J Plant, Anim Environ Sci 1:1\u20137","journal-title":"Int J Plant, Anim Environ Sci"},{"key":"1112_CR29","doi-asserted-by":"publisher","first-page":"976","DOI":"10.1111\/j.1440-1746.2008.05333.x","volume":"23","author":"SW Park","year":"2008","unstructured":"Park SW, Oh TY, Kim YS, Sim H, Park SJ, Jang EJ et al (2008) Artemisia asiatica extracts protect against ethanol-induced injury in gastric mucosa of rats. J Gastroenterol Hepatol 23:976\u2013984. https:\/\/doi.org\/10.1111\/j.1440-1746.2008.05333.x","journal-title":"J Gastroenterol Hepatol"},{"key":"1112_CR30","doi-asserted-by":"publisher","first-page":"265","DOI":"10.3390\/biom10020265","volume":"10","author":"LL P\u00e9rico","year":"2020","unstructured":"P\u00e9rico LL, Em\u00edlio-Silva MT, Ohara R, Rodrigues VP, Bueno G, Barbosa-Filho JM et al (2020) Systematic analysis of monoterpenes: advances and challenges in the treatment of peptic ulcer diseases. Biomolecules 10:265. https:\/\/doi.org\/10.3390\/biom10020265","journal-title":"Biomolecules"},{"key":"1112_CR31","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/1472-6882-6-39.20","volume":"6","author":"S Prabuseenivasan","year":"2006","unstructured":"Prabuseenivasan S, Jayakumar M, Ignacimuthu S (2006) In vitro antibacterial activity of some plant essential oils. BMC Complement Altern Med 6:1\u20138. https:\/\/doi.org\/10.1186\/1472-6882-6-39.20","journal-title":"BMC Complement Altern Med"},{"key":"1112_CR32","doi-asserted-by":"publisher","first-page":"547","DOI":"10.1177\/0960327119895559","volume":"39","author":"Z Rahman","year":"2020","unstructured":"Rahman Z, Dwivedi D, Jena G (2020) Ethanol-induced gastric ulcer in rats and intervention of tert-butylhydroquinone: involvement of Nrf2\/HO-1 signalling pathway. Hum Exp Toxicol 39:547\u2013562. https:\/\/doi.org\/10.1177\/0960327119895559","journal-title":"Hum Exp Toxicol"},{"key":"1112_CR33","doi-asserted-by":"publisher","first-page":"101","DOI":"10.3389\/fphar.2021.622815","volume":"12","author":"M Raish","year":"2021","unstructured":"Raish M, Shahid M, Bin Jardan YA, Ansari MA, Alkharfy KM, Ahad A et al (2021) Gastroprotective effect of sinapic acid on ethanol-induced gastric ulcers in rats: involvement of Nrf2\/HO-1 and NF-\u03baB signaling and antiapoptotic role. Front Pharmacol 12:101. https:\/\/doi.org\/10.3389\/fphar.2021.622815","journal-title":"Front Pharmacol"},{"key":"1112_CR34","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0071762","volume":"8","author":"E Sangiovanni","year":"2013","unstructured":"Sangiovanni E, Vrhovsek U, Rossoni G, Colombo E, Brunelli C, Brembati L et al (2013) Ellagitannins from Rubus berries for the control of gastric inflammation: in vitro and in vivo studies. PLoS ONE 8:e71762. https:\/\/doi.org\/10.1371\/journal.pone.0071762","journal-title":"PLoS ONE"},{"key":"1112_CR35","doi-asserted-by":"publisher","first-page":"511","DOI":"10.1515\/znc-2005-7-801","volume":"60","author":"G Schmeda-Hirschmanna","year":"2005","unstructured":"Schmeda-Hirschmanna G, Astudillo L, Sep\u00falveda B, Rodr\u00edguez JA, Theoduloz C, Y\u00e1\u00f1ez T et al (2005) Gastroprotective effect and cytotoxicity of natural and semisynthetic labdane diterpenes from Araucaria araucana resin. Zeitschrift F\u00fcr Naturforschung C 60:511\u2013522. https:\/\/doi.org\/10.1515\/znc-2005-7-801","journal-title":"Zeitschrift F\u00fcr Naturforschung C"},{"key":"1112_CR36","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1210\/en.2002-220756","volume":"144","author":"V Sibilia","year":"2003","unstructured":"Sibilia V, Rindi G, Pagani F, Rapetti D, Locatelli V, Torsello A et al (2003) Ghrelin protects against ethanol-induced gastric ulcers in rats: studies on the mechanisms of action. Endocrinology 144:353\u2013359. https:\/\/doi.org\/10.1210\/en.2002-220756","journal-title":"Endocrinology"},{"key":"1112_CR37","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/1472-6882-13-183","volume":"13","author":"HMA Sidahmed","year":"2013","unstructured":"Sidahmed HMA, Azizan AHS, Mohan S, Abdulla MA, Abdelwahab SI, Taha MME et al (2013) Gastroprotective effect of desmosdumotin C isolated from Mitrella kentii against ethanol-induced gastric mucosal hemorrhage in rats: possible involvement of glutathione, heat-shock protein-70, sulfhydryl compounds, nitric oxide, and anti-Helicobacter pylori activity. BMC Complement Altern Med 13:1\u201315","journal-title":"BMC Complement Altern Med"},{"key":"1112_CR38","doi-asserted-by":"publisher","first-page":"8022","DOI":"10.1016\/S0021-9258(17)37154-5","volume":"269","author":"J Sikkema","year":"1994","unstructured":"Sikkema J, de Bont JA, Poolman B (1994) Interactions of cyclic hydrocarbons with biological membranes. J Biol Chem 269:8022\u20138028","journal-title":"J Biol Chem"},{"key":"1112_CR39","doi-asserted-by":"publisher","first-page":"1734","DOI":"10.1016\/j.fct.2010.04.001","volume":"48","author":"P Singh","year":"2010","unstructured":"Singh P, Shukla R, Prakash B, Kumar A, Singh S, Mishra PK et al (2010) Chemical profile, antifungal, antiaflatoxigenic and antioxidant activity of Citrus maxima Burm. and Citrus sinensis (L.) Osbeck essential oils and their cyclic monoterpene. DL-Limonene Food Chem Toxicol 48:1734\u20131740. https:\/\/doi.org\/10.1016\/j.fct.2010.04.001","journal-title":"DL-Limonene Food Chem Toxicol"},{"key":"1112_CR40","doi-asserted-by":"publisher","first-page":"64","DOI":"10.3390\/medicina55030064","volume":"55","author":"N Sistani Karampour","year":"2019","unstructured":"Sistani Karampour N, Arzi A, Rezaie A, Pashmforoosh M, Kordi F (2019) Gastroprotective effect of zingerone on ethanol-induced gastric ulcers in rats. Medicina 55:64. https:\/\/doi.org\/10.3390\/medicina55030064","journal-title":"Medicina"},{"key":"1112_CR41","doi-asserted-by":"publisher","first-page":"49423","DOI":"10.1039\/C7RA10283F","volume":"7","author":"M Su","year":"2017","unstructured":"Su M, Li C-Y, Zhou L, Yan Y-Y, Ao L-Y, Wang G-J et al (2017) Anti-ulcerogenic effect of KFP-H008 against ethanol-induced gastric ulcer via p38 MAPK\/NF-\u03baB pathway. RSC Adv 7:49423\u201349435. https:\/\/doi.org\/10.1039\/C7RA10283F","journal-title":"RSC Adv"},{"key":"1112_CR42","doi-asserted-by":"publisher","first-page":"G1296","DOI":"10.1152\/ajpgi.2001.280.6.G1296","volume":"280","author":"S Takahashi","year":"2001","unstructured":"Takahashi S, Fujita T, Yamamoto A (2001) Role of nuclear factor-\u03baB in gastric ulcer healing in rats. Am J Physiol-Gastrointest Liver Physiol 280:G1296\u2013G1304. https:\/\/doi.org\/10.1152\/ajpgi.2001.280.6.G1296","journal-title":"Am J Physiol-Gastrointest Liver Physiol"},{"key":"1112_CR43","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1016\/j.jep.2018.07.026","volume":"226","author":"AN Talaat","year":"2018","unstructured":"Talaat AN, Ebada SS, Labib RM, Esmat A, Youssef FS, Singab ANB (2018) Verification of the anti-inflammatory activity of the polyphenolic-rich fraction of Araucaria bidwillii Hook using phytohaemagglutinin-stimulated human peripheral blood mononuclear cells and virtual screening. J Ethnopharmacol 226:44\u201347. https:\/\/doi.org\/10.1016\/j.jep.2018.07.026","journal-title":"J Ethnopharmacol"},{"key":"1112_CR44","doi-asserted-by":"publisher","first-page":"410","DOI":"10.1016\/j.indcrop.2014.07.040","volume":"61","author":"RS Verma","year":"2014","unstructured":"Verma RS, Padalia RC, Goswami P, Verma SK, Chauhan A, Darokar MP (2014) Chemical composition and antibacterial activity of foliage and resin essential oils of Araucaria cunninghamii Aiton ex D. Don and Araucaria heterophylla (Salisb.) Franco from India. Ind Crops Prod 61:410\u2013416. https:\/\/doi.org\/10.1016\/j.indcrop.2014.07.040","journal-title":"Ind Crops Prod"},{"key":"1112_CR45","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2021.819506","author":"Y-H Wang","year":"2022","unstructured":"Wang Y-H, Gong X-L, Liu D-W, Zeng R, Zhou L-F, Sun X-Y et al (2022) Characteristics of Helicobacter pylori heteroresistance in gastric biopsies and its clinical relevance. Front Cell Infect Microbiol. https:\/\/doi.org\/10.3389\/fcimb.2021.819506","journal-title":"Front Cell Infect Microbiol"},{"key":"1112_CR46","doi-asserted-by":"publisher","first-page":"1362","DOI":"10.1016\/j.fct.2010.03.002","volume":"48","author":"WA Wannes","year":"2010","unstructured":"Wannes WA, Mhamdi B, Sriti J, Jemia MB, Ouchikh O, Hamdaoui G et al (2010) Antioxidant activities of the essential oils and methanol extracts from myrtle (Myrtus communis var. italica L.) leaf, stem and flower. Food Chem Toxicol 48:1362\u20131370. https:\/\/doi.org\/10.1016\/j.fct.2010.03.002","journal-title":"Food Chem Toxicol"},{"key":"1112_CR47","doi-asserted-by":"publisher","first-page":"808","DOI":"10.3390\/nu12030808","volume":"12","author":"J-H Yoo","year":"2020","unstructured":"Yoo J-H, Park E-J, Kim SH, Lee H-J (2020) Gastroprotective effects of fermented lotus root against ethanol\/HCl-induced gastric mucosal acute toxicity in rats. Nutrients 12:808. https:\/\/doi.org\/10.3390\/nu12030808","journal-title":"Nutrients"},{"key":"1112_CR48","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/7395032","author":"W-C Zhao","year":"2017","unstructured":"Zhao W-C, Xu Y-S, Chen G, Guo Y, Wang D-Y, Meng G-B (2017) Veronicastrum axillare alleviates ethanol-induced injury on gastric epithelial cells via downregulation of the NF-kB signaling pathway. Gastroenterol Res Pract. https:\/\/doi.org\/10.1155\/2017\/7395032","journal-title":"Gastroenterol Res Pract"},{"key":"1112_CR49","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2020.110075","volume":"126","author":"D Zhou","year":"2020","unstructured":"Zhou D, Yang Q, Tian T, Chang Y, Li Y, Duan L-R et al (2020) Gastroprotective effect of gallic acid against ethanol-induced gastric ulcer in rats: involvement of the Nrf2\/HO-1 signaling and anti-apoptosis role. Biomed Pharmacother 126:110075. https:\/\/doi.org\/10.1016\/j.biopha.2020.110075","journal-title":"Biomed Pharmacother"}],"container-title":["Inflammopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10787-022-01112-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10787-022-01112-w\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10787-022-01112-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,24]],"date-time":"2023-02-24T04:40:01Z","timestamp":1677213601000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10787-022-01112-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12,21]]},"references-count":49,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2023,2]]}},"alternative-id":["1112"],"URL":"https:\/\/doi.org\/10.1007\/s10787-022-01112-w","relation":{},"ISSN":["0925-4692","1568-5608"],"issn-type":[{"value":"0925-4692","type":"print"},{"value":"1568-5608","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,12,21]]},"assertion":[{"value":"13 September 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 December 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 December 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors have no relevant financial or non-financial interests to disclose.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"All experimental procedures were approved by the \u201cUnit of Research Ethics Approval Committee, Pharos University in Alexandria\u201d (PUA01202206263035). All the procedures followed the Guidelines for the Care and Use of Laboratory Animals (NIH) and the Animal Research: Reporting of in vivo Experiments (ARRIVE).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}]}}