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Ebselen (EB), a synthesized versatile organo-selenium compound, protects cells from reactive oxygen species (ROS)-induced injury by mimicking glutathione peroxidase (GPx) action. This study aimed to investigate the antioxidant and anti-inflammatory effects of EB in an arthritic irradiated model. This goal was achieved by subjecting adjuvant-induced arthritis (AIA) rats to fractionated whole body \u03b3-irradiation (2\u00a0Gy\/fraction once per week for 3 consecutive weeks, for a total dose of 6\u00a0Gy) and treating them with EB (20\u00a0mg\/kg\/day, p.o) or methotrexate (MTX; 0.05\u00a0mg\/kg; twice\/week, i.p) as a reference anti-RA drug. The arthritic clinical signs, oxidative stress and antioxidant biomarkers, inflammatory response, expression of NOD-like receptor protein-3 (NLRP-3) inflammasome, receptor activator of nuclear factor \u03baB ligand (RANKL), nuclear factor-\u03baB (NF-\u03baB), apoptotic indicators (caspase 1 and caspase 3), cartilage integrity marker (collagen-II), and histopathological examination of ankle joints were assessed. EB notably improved the severity of arthritic clinical signs, alleviated joint histopathological lesions, modulated oxidative stress and inflammation in serum and synovium, as well as reduced NLRP-3, RANKL, and caspase3 expression while boosting collagen-II expression in the ankle joints of arthritic and arthritic irradiated rats with comparable potency to MTX. Our findings suggest that EB, through its antioxidant and anti-inflammatory properties, has anti-arthritic and radioprotective properties in an arthritic irradiated model.<\/jats:p>","DOI":"10.1007\/s10787-023-01238-5","type":"journal-article","created":{"date-parts":[[2023,5,2]],"date-time":"2023-05-02T18:07:48Z","timestamp":1683050868000},"page":"1929-1949","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Fractionated whole body \u03b3-irradiation aggravates arthritic severity via boosting NLRP3 and RANKL expression in adjuvant-induced arthritis model: the mitigative potential of ebselen"],"prefix":"10.1007","volume":"31","author":[{"given":"Noura M.","family":"Thabet","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7091-8955","authenticated-orcid":false,"given":"Mohamed K.","family":"Abdel-Rafei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed M.","family":"Amin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,5,2]]},"reference":[{"key":"1238_CR1","doi-asserted-by":"publisher","first-page":"118410","DOI":"10.1016\/j.lfs.2020.118410","volume":"260","author":"MK Abdel-Rafei","year":"2020","unstructured":"Abdel-Rafei MK, Thabet NM (2020) Modulatory effect of methylsulfonylmethane against BPA\/\u03b3-radiation induced neurodegenerative alterations in rats: influence of TREM-2\/DAP-12\/Syk pathway. 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