{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T20:35:41Z","timestamp":1791837341022,"version":"4.3.4"},"reference-count":48,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2023,7,17]],"date-time":"2023-07-17T00:00:00Z","timestamp":1689552000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2023,7,17]],"date-time":"2023-07-17T00:00:00Z","timestamp":1689552000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Heliopolis University"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Inflammopharmacol"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Necroptosis, a programmed form of necrotic cell death carried out by receptor-interacting serine\/threonine protein kinase 1 (RIPK1) and RIPK3, has been found to be implicated in the pathogenesis of Alzheimer\u2019s disease (AD). An FDA-approved anti-cancer drug, pazopanib, is reported to possess potent inhibitory effect against necroptosis via interfering with RIPK1. So far, there are no existing data on the influence of pazopanib on necroptotic pathway in AD. Thus, this study was designed to explore the impact of pazopanib on cognitive impairment provoked by ovariectomy (OVX) together with D-galactose (D-Gal) administration in rats and to scrutinize the putative signaling pathways underlying pazopanib-induced effects. Animals were allocated into four groups; the first and second groups were exposed to sham operation and administered normal saline and pazopanib (5\u00a0mg\/kg\/day, i.p.), respectively, for 6\u00a0weeks, while the third and fourth groups underwent OVX then were injected with D-Gal (150\u00a0mg\/kg\/day, i.p.); concomitantly with pazopanib in the fourth group for 6\u00a0weeks. Pazopanib ameliorated cognitive deficits as manifested by improved performance in the Morris water maze besides reversing the histological abnormalities. Pazopanib produced a significant decline in p-Tau and amyloid beta (A\u03b2) plaques. The neuroprotective effect of pazopanib was revealed by hampering neuroinflammation, mitigating neuronal death and suppressing RIPK1\/RIPK3\/MLKL necroptosis signaling pathway. Accordingly, hindering neuroinflammation and the necroptotic RIPK1\/RIPK3\/MLKL pathway could contribute to the neuroprotective effect of pazopanib in D-Gal\/OVX rat model. Therefore, this study reveals pazopanib as a valuable therapeutic agent in AD that warrants future inspection to provide further data regarding its neuroprotective effect.<\/jats:p>","DOI":"10.1007\/s10787-023-01269-y","type":"journal-article","created":{"date-parts":[[2023,7,17]],"date-time":"2023-07-17T07:02:12Z","timestamp":1689577332000},"page":"2719-2729","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Cognitive enhancing effects of pazopanib in D\u2011galactose\/ovariectomized Alzheimer\u2019s rat model: insights into the role of RIPK1\/RIPK3\/MLKL necroptosis signaling pathway"],"prefix":"10.1007","volume":"31","author":[{"given":"Rasha","family":"Abdelhady","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nancy S.","family":"Younis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omaima","family":"Ali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samah","family":"Shehata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rabab H.","family":"Sayed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4619-685X","authenticated-orcid":false,"given":"Rania I.","family":"Nadeem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,7,17]]},"reference":[{"key":"1269_CR1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0265961","author":"SS Abd El-Rahman","year":"2022","unstructured":"Abd El-Rahman SS, Fayed HM (2022) Improved cognition impairment by activating cannabinoid receptor type 2: Modulating CREB\/BDNF expression and impeding TLR-4\/ NF\u03baBp65\/M1 microglia signaling pathway in D-galactose-injected ovariectomized rats. PLoS ONE. https:\/\/doi.org\/10.1371\/journal.pone.0265961","journal-title":"PLoS ONE"},{"key":"1269_CR2","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1002\/alz.12328","volume":"17","author":"Alzheimer's Association Report","year":"2021","unstructured":"Alzheimer\u2019s Association Report (2021) Alzheimer\u2019s disease facts and figures. Alzheimer\u2019s Association Report 17:327\u2013406. https:\/\/doi.org\/10.1002\/alz.12328","journal-title":"Alzheimer's Association Report"},{"key":"1269_CR3","doi-asserted-by":"crossref","unstructured":"Bu\u00e9e L, Bussi\u00e8re T, Bu\u00e9e-Scherrer V, et al (2000) Tau protein isoforms, phosphorylation and role in neurodegenerative disorders. Brain Res Rev 33","DOI":"10.1016\/S0165-0173(00)00019-9"},{"key":"1269_CR4","doi-asserted-by":"publisher","DOI":"10.1038\/nn.4608","author":"A Caccamo","year":"2017","unstructured":"Caccamo A, Branca C, Piras IS et al (2017) Necroptosis activation in Alzheimer\u2019s disease. Nat Neurosci. https:\/\/doi.org\/10.1038\/nn.4608","journal-title":"Nat Neurosci"},{"issue":"1","key":"1269_CR5","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1159\/000481795","volume":"63","author":"B Cetin","year":"2018","unstructured":"Cetin B, Y\u0131lmaz GE, Armagan B, Afsar B, Demirci U, Gulbahar O, Gumusay O, Bilgetekin I, Ozet A, Uner A (2018) Pazopanib-Induced hepatotoxicity in an experimental rat model. Chemotherapy 63(1):39\u201345. https:\/\/doi.org\/10.1159\/000481795","journal-title":"Chemotherapy"},{"key":"1269_CR6","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2009.05.037","author":"YS Cho","year":"2009","unstructured":"Cho YS, Challa S, Moquin D et al (2009) Phosphorylation-driven assembly of the RIP1-RIP3 complex regulates programmed necrosis and virus-induced inflammation. Cell. https:\/\/doi.org\/10.1016\/j.cell.2009.05.037","journal-title":"Cell"},{"key":"1269_CR7","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2012.64","author":"DE Christofferson","year":"2012","unstructured":"Christofferson DE, Li Y, Hitomi J et al (2012) A novel role for RIP1 kinase in mediating TNFa production. Cell Death Dis. https:\/\/doi.org\/10.1038\/cddis.2012.64","journal-title":"Cell Death Dis"},{"key":"1269_CR8","volume-title":"Handbook of histopathological and histochemical techniques","author":"CFA Culling","year":"1974","unstructured":"Culling CFA (1974) Handbook of histopathological and histochemical techniques, 3rd edn. Butterworth-Heinemann","edition":"3"},{"key":"1269_CR9","doi-asserted-by":"publisher","DOI":"10.1038\/nchembio711","author":"A Degterev","year":"2005","unstructured":"Degterev A, Huang Z, Boyce M et al (2005) Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury. Nat Chem Biol. https:\/\/doi.org\/10.1038\/nchembio711","journal-title":"Nat Chem Biol"},{"key":"1269_CR10","doi-asserted-by":"publisher","DOI":"10.1038\/nchembio.83","author":"A Degterev","year":"2008","unstructured":"Degterev A, Hitomi J, Germscheid M et al (2008) Identification of RIP1 kinase as a specific cellular target of necrostatins. Nat Chem Biol. https:\/\/doi.org\/10.1038\/nchembio.83","journal-title":"Nat Chem Biol"},{"key":"1269_CR11","doi-asserted-by":"crossref","unstructured":"Deture MA, Dickson DW (2019) The neuropathological diagnosis of Alzheimer\u2019s disease. Mol Neurodegener 14","DOI":"10.1186\/s13024-019-0333-5"},{"key":"1269_CR12","doi-asserted-by":"crossref","unstructured":"Dhuriya YK, Sharma D (2018) Necroptosis: A regulated inflammatory mode of cell death. J Neuroinflammation 15","DOI":"10.1186\/s12974-018-1235-0"},{"key":"1269_CR13","doi-asserted-by":"publisher","DOI":"10.1007\/s00210-015-1157-7","author":"M Elshal","year":"2015","unstructured":"Elshal M, Abu-Elsaad N, El-Karef A, Ibrahim TM (2015) The multi-kinase inhibitor pazopanib targets hepatic stellate cell activation and apoptosis alleviating progression of liver fibrosis. Naunyn Schmiedebergs Arch Pharmacol. https:\/\/doi.org\/10.1007\/s00210-015-1157-7","journal-title":"Naunyn Schmiedebergs Arch Pharmacol"},{"key":"1269_CR14","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2015.130","author":"A Fauster","year":"2015","unstructured":"Fauster A, Rebsamen M, Huber KVM et al (2015) A cellular screen identifies ponatinib and pazopanib as inhibitors of necroptosis. Cell Death Dis. https:\/\/doi.org\/10.1038\/cddis.2015.130","journal-title":"Cell Death Dis"},{"key":"1269_CR15","doi-asserted-by":"publisher","first-page":"103516","DOI":"10.1016\/J.JDDST.2022.103516","volume":"74","author":"HA Gad","year":"2022","unstructured":"Gad HA, Mansour M, Abbas H et al (2022) \u201cPlurol will not miss the boat\u201d: A new manifesto of galantamine conveyance. J Drug Deliv Sci Technol 74:103516. https:\/\/doi.org\/10.1016\/J.JDDST.2022.103516","journal-title":"J Drug Deliv Sci Technol"},{"key":"1269_CR16","doi-asserted-by":"publisher","first-page":"918","DOI":"10.1016\/j.cell.2010.02.016","volume":"140","author":"CK Glass","year":"2010","unstructured":"Glass CK, Saijo K, Winner B et al (2010) Mechanisms Underlying inflammation in neurodegeneration. Cell 140:918","journal-title":"Cell"},{"key":"1269_CR17","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2007.02.030","author":"X Hua","year":"2007","unstructured":"Hua X, Lei M, Zhang Y et al (2007) Long-term d-galactose injection combined with ovariectomy serves as a new rodent model for Alzheimer\u2019s disease. Life Sci. https:\/\/doi.org\/10.1016\/j.lfs.2007.02.030","journal-title":"Life Sci"},{"key":"1269_CR18","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-46558-1","author":"WW Ibrahim","year":"2019","unstructured":"Ibrahim WW, Abdelkader NF, Ismail HM, Khattab MM (2019) Escitalopram ameliorates cognitive impairment in D-Galactose-injected ovariectomized rats: modulation of JNK, GSK-3\u03b2, and ERK signalling pathways. Sci Rep. https:\/\/doi.org\/10.1038\/s41598-019-46558-1","journal-title":"Sci Rep"},{"key":"1269_CR19","doi-asserted-by":"publisher","first-page":"115028","DOI":"10.1016\/J.TAAP.2020.115028","volume":"398","author":"WW Ibrahim","year":"2020","unstructured":"Ibrahim WW, Ismail HM, Khattab MM, Abdelkader NF (2020) Cognitive enhancing effect of diapocynin in D-galactose-ovariectomy-induced Alzheimer\u2019s-like disease in rats: Role of ERK, GSK-3\u03b2, and JNK signaling. Toxicol Appl Pharmacol 398:115028. https:\/\/doi.org\/10.1016\/J.TAAP.2020.115028","journal-title":"Toxicol Appl Pharmacol"},{"key":"1269_CR20","doi-asserted-by":"publisher","first-page":"2505","DOI":"10.1007\/s10787-022-00973-5","volume":"30","author":"WW Ibrahim","year":"2022","unstructured":"Ibrahim WW, Kamel AS, Wahid AAN (2022) Dapagliflozin as an autophagic enhancer via LKB1\/AMPK\/SIRT1 pathway in ovariectomized\/D-galactose Alzheimer\u2019s rat model. Inflammopharmacology 30:2505\u20132520. https:\/\/doi.org\/10.1007\/s10787-022-00973-5","journal-title":"Inflammopharmacology"},{"key":"1269_CR21","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaf6803","author":"Y Ito","year":"1979","unstructured":"Ito Y, Ofengeim D, Najafov A et al (1979) (2016) RIPK1 mediates axonal degeneration by promoting inflammation and necroptosis in ALS. Science. https:\/\/doi.org\/10.1126\/science.aaf6803","journal-title":"Science"},{"key":"1269_CR22","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-170429","author":"M Javidnia","year":"2017","unstructured":"Javidnia M, Hebron ML, Xin Y et al (2017) Pazopanib reduces phosphorylated tau levels and alters astrocytes in a mouse model of tauopathy. J Alzheimer\u2019s Dis. https:\/\/doi.org\/10.3233\/JAD-170429","journal-title":"J Alzheimer\u2019s Dis"},{"key":"1269_CR23","doi-asserted-by":"publisher","DOI":"10.1186\/s40478-021-01264-w","author":"A Jayaraman","year":"2021","unstructured":"Jayaraman A, Htike TT, James R et al (2021) TNF-mediated neuroinflammation is linked to neuronal necroptosis in Alzheimer\u2019s disease hippocampus. Acta Neuropathol Commun. https:\/\/doi.org\/10.1186\/s40478-021-01264-w","journal-title":"Acta Neuropathol Commun"},{"key":"1269_CR24","doi-asserted-by":"crossref","unstructured":"Khajuria DK, Razdan R, Mahapatra DR (2012) Description of a new method of ovariectomy in female rats. Rev Bras Reumatol 52:","DOI":"10.1590\/S0482-50042012000300016"},{"key":"1269_CR25","doi-asserted-by":"crossref","unstructured":"Khan SS, Bloom GS (2016) Tau: The Center of a Signaling Nexus in Alzheimer\u2019s Disease. Front Neurosci 10","DOI":"10.3389\/fnins.2016.00031"},{"key":"1269_CR26","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhq002","author":"J Lu","year":"2010","unstructured":"Lu J, Wu DM, Zheng YL et al (2010) Ursolic acid attenuates D-galactose-induced inflammatory response in mouse prefrontal cortex through inhibiting AGEs\/RAGE\/NF-\u03baB pathway activation. Cereb Cortex. https:\/\/doi.org\/10.1093\/cercor\/bhq002","journal-title":"Cereb Cortex"},{"key":"1269_CR27","doi-asserted-by":"crossref","unstructured":"Mandrekar S, Landreth GE (2010) Microglia and Inflammation in Alzheimer\u2019s Disease. CNS Neurol Disord Drug Targets 9:","DOI":"10.2174\/187152710791012071"},{"key":"1269_CR28","doi-asserted-by":"publisher","DOI":"10.1016\/0023-9690(81)90020-5","author":"RGM Morris","year":"1981","unstructured":"Morris RGM (1981) Spatial localization does not require the presence of local cues. Learn Motiv. https:\/\/doi.org\/10.1016\/0023-9690(81)90020-5","journal-title":"Learn Motiv"},{"issue":"2","key":"1269_CR29","doi-asserted-by":"publisher","first-page":"27","DOI":"10.4103\/0976-0105.177703","volume":"7","author":"AB Nair","year":"2016","unstructured":"Nair AB, Jacob S (2016) A simple practice guide for dose conversion between animals and human. J Basic Clin Pharm 7(2):27\u201331. https:\/\/doi.org\/10.4103\/0976-0105.177703","journal-title":"J Basic Clin Pharm"},{"key":"1269_CR30","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2016.06.007","author":"M Najjar","year":"2016","unstructured":"Najjar M, Saleh D, Zelic M et al (2016) RIPK1 and RIPK3 kinases promote cell-death-independent inflammation by toll-like receptor 4. Immunity. https:\/\/doi.org\/10.1016\/j.immuni.2016.06.007","journal-title":"Immunity"},{"key":"1269_CR31","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2015.02.051","author":"D Ofengeim","year":"2015","unstructured":"Ofengeim D, Ito Y, Najafov A et al (2015) Activation of necroptosis in multiple sclerosis. Cell Rep. https:\/\/doi.org\/10.1016\/j.celrep.2015.02.051","journal-title":"Cell Rep"},{"key":"1269_CR32","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1714175114","author":"D Ofengeim","year":"2017","unstructured":"Ofengeim D, Mazzitelli S, Ito Y et al (2017) RIPK1 mediates a disease-associated microglial response in Alzheimer\u2019s disease. Proc Natl Acad Sci USA. https:\/\/doi.org\/10.1073\/pnas.1714175114","journal-title":"Proc Natl Acad Sci USA"},{"key":"1269_CR33","doi-asserted-by":"crossref","unstructured":"Ofengeim D, Yuan J (2013) Regulation of RIP1 kinase signalling at the crossroads of inflammation and cell death. Nat Rev Mol Cell Biol 14","DOI":"10.1038\/nrm3683"},{"key":"1269_CR34","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2014.01.011","author":"DB Re","year":"2014","unstructured":"Re DB, Le Verche V, Yu C et al (2014) Necroptosis drives motor neuron death in models of both sporadic and familial ALS. Neuron. https:\/\/doi.org\/10.1016\/j.neuron.2014.01.011","journal-title":"Neuron"},{"key":"1269_CR35","doi-asserted-by":"crossref","unstructured":"Rubio-Perez JM, Morillas-Ruiz JM (2012) A review: Inflammatory process in Alzheimer\u2019s disease, role of cytokines. The Scientific World Journal 2012","DOI":"10.1100\/2012\/756357"},{"key":"1269_CR36","first-page":"21","volume-title":"Alzheimer\u2019s Disease. Current clinical neurology","author":"C Schultz","year":"2004","unstructured":"Schultz C, Del Tredici K, Braak H (2004) Neuropathology of Alzheimer\u2019s disease. In: Richter RW, Ritcher BZ (eds) Alzheimer\u2019s Disease. Current clinical neurology. Humana Press, Totowa, NJ, pp 21\u201331"},{"key":"1269_CR37","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a006189","author":"A Serrano-Pozo","year":"2011","unstructured":"Serrano-Pozo A, Frosch MP, Masliah E, Hyman BT (2011) Neuropathological alterations in Alzheimer disease. Cold Spring Harb Perspect Med. https:\/\/doi.org\/10.1101\/cshperspect.a006189","journal-title":"Cold Spring Harb Perspect Med"},{"key":"1269_CR38","doi-asserted-by":"publisher","DOI":"10.22034\/APJCP.2017.18.11.2977","author":"LV Spirina","year":"2017","unstructured":"Spirina LV, Usynin EA, Yurmazov ZA et al (2017) Effect of targeted therapy with Pazopanib on expression levels of transcription, growth factors and components of AKT\/m-TOR signaling pathway in patients with renal cell carcinoma. Asian Pacific J Cancer Prev. https:\/\/doi.org\/10.22034\/APJCP.2017.18.11.2977","journal-title":"Asian Pacific J Cancer Prev"},{"key":"1269_CR39","doi-asserted-by":"crossref","unstructured":"Tamagno E, Guglielmotto M, Monteleone D, et al (2012) Transcriptional and post-transcriptional regulation of \u03b2-secretase. IUBMB Life 64","DOI":"10.1002\/iub.1099"},{"key":"1269_CR40","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2014.03.003","author":"H Wang","year":"2014","unstructured":"Wang H, Sun L, Su L et al (2014) Mixed lineage kinase domain-like protein MLKL causes necrotic membrane disruption upon phosphorylation by RIP3. Mol Cell. https:\/\/doi.org\/10.1016\/j.molcel.2014.03.003","journal-title":"Mol Cell"},{"key":"1269_CR41","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.7798","author":"YJ Wang","year":"2016","unstructured":"Wang YJ, Ren QG, Gong WG et al (2016) Escitalopram attenuates \u03b2-amyloid-induced tau hyperphosphorylation in primary hippocampal neurons through the 5-HT1A receptor mediated Akt\/GSK-3\u03b2 pathway. Oncotarget. https:\/\/doi.org\/10.18632\/oncotarget.7798","journal-title":"Oncotarget"},{"key":"1269_CR42","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1038\/nrm.2016.149","volume":"18","author":"R Weinlich","year":"2017","unstructured":"Weinlich R, Oberst A, Beere HM, Green DR (2017) Necroptosis in development, inflammation and disease. Nat Rev Mol Cell Biol 18:127","journal-title":"Nat Rev Mol Cell Biol"},{"key":"1269_CR43","doi-asserted-by":"publisher","first-page":"a006171","DOI":"10.1101\/cshperspect.a006171","volume":"2","author":"S Weintraub","year":"2012","unstructured":"Weintraub S, Wicklund AH, Salmon DP (2012) The neuropsychological profile of Alzheimer disease. Cold Spring Harb Perspect Med 2:a006171","journal-title":"Cold Spring Harb Perspect Med"},{"key":"1269_CR44","doi-asserted-by":"publisher","DOI":"10.1039\/c4sc03416c","author":"Y Yang","year":"2015","unstructured":"Yang Y, Li G, Zhao D et al (2015) Computational discovery and experimental verification of tyrosine kinase inhibitor pazopanib for the reversal of memory and cognitive deficits in rat model neurodegeneration. Chem Sci. https:\/\/doi.org\/10.1039\/c4sc03416c","journal-title":"Chem Sci"},{"key":"1269_CR45","doi-asserted-by":"publisher","DOI":"10.15252\/emmm.201606566","author":"S Yang","year":"2017","unstructured":"Yang S, Lee DK, Shin J et al (2017) Nec-1 alleviates cognitive impairment with reduction of A\u03b2 and tau abnormalities in APP \/ PS 1 mice. EMBO Mol Med. https:\/\/doi.org\/10.15252\/emmm.201606566","journal-title":"EMBO Mol Med"},{"key":"1269_CR46","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1038\/s41583-018-0093-1","volume":"20","author":"J Yuan","year":"2019","unstructured":"Yuan J, Amin P, Ofengeim D (2019) Necroptosis and RIPK1-mediated neuroinflammation in CNS diseases. Nat Rev Neurosci 20:19\u201333","journal-title":"Nat Rev Neurosci"},{"key":"1269_CR47","doi-asserted-by":"publisher","first-page":"2181","DOI":"10.7150\/ijbs.57078","volume":"17","author":"H Zhang","year":"2021","unstructured":"Zhang H, Wei W, Zhao M et al (2021) Interaction between a\u03b2 and tau in the pathogenesis of alzheimer\u2019s disease. Int J Biol Sci 17:2181\u20132192. https:\/\/doi.org\/10.7150\/ijbs.57078","journal-title":"Int J Biol Sci"},{"key":"1269_CR48","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2014.00167","author":"Y Zhao","year":"2014","unstructured":"Zhao Y, Hill JM, Bhattacharjee S et al (2014) Aluminum-induced amyloidogenesis and impairment in the clearance of amyloid peptides from the central nervous system (cns) in Alzheimer\u2019s disease (AD). Front Neurol. https:\/\/doi.org\/10.3389\/fneur.2014.00167","journal-title":"Front Neurol"}],"container-title":["Inflammopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10787-023-01269-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10787-023-01269-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10787-023-01269-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T21:12:34Z","timestamp":1695589954000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10787-023-01269-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7,17]]},"references-count":48,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2023,10]]}},"alternative-id":["1269"],"URL":"https:\/\/doi.org\/10.1007\/s10787-023-01269-y","relation":{},"ISSN":["0925-4692","1568-5608"],"issn-type":[{"value":"0925-4692","type":"print"},{"value":"1568-5608","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,7,17]]},"assertion":[{"value":"7 May 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 June 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 July 2023","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The protocol of this study was conducted in accordance with the ethical procedures and policies approved by the Ethics Committee for Animal Experimentation at Faculty of Pharmacy, Cairo University; PT (2991) and complied with the terms of the US National Institutes of Health guide for the Care and Use of Laboratory Animals (NIH Publication No. 85\u201323, revised 1996).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}]}}