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One of the factors leading to the imbalance between the pathways of tryptophan metabolism is inflammation. The aim of our study was to assess the impact of treatment with tumor necrosis factor-alpha (TNF\u03b1)-inhibitors on tryptophan metabolism in patients with ankylosing spondylitis (AS). Forty patients with AS (twenty-eight males, twelve females; mean age 40\u2009\u00b1\u200911\u00a0years), qualified to receive anti-TNF-\u03b1 treatment, were prospectively assessed. As a control group, 20 healthy volunteers (7 males and 13 females, mean age 38\u2009\u00b1\u20095\u00a0years) were recruited from the general population. Patients underwent full clinical and biochemical assessment before and after 6\u00a0months of therapy. Disease activity was assessed by the Bath Ankylosing Spondylitis Disease Activity Index (BASDAI). The presence of depressive disorders was assessed with Beck's Depression Inventory (BDI) scale. Serum concentrations of tryptophan, serotonin, kynurenine, and quinolinic acid were measured. The predominance of the kynurenine pathway in AS patients (compared to the control group) was demonstrated (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). Surprisingly, no significant changes in serum levels of tryptophan and its metabolites in AS patients after treatment were found, despite clinical improvement. Moreover, the components of tryptophan metabolism did not correlate significantly with the clinical activity of AS, depression nor laboratory inflammatory markers. Probably some other factors influence the pathways of tryptophan metabolism in patients with ankylosing spondylitis.<\/jats:p>","DOI":"10.1007\/s10787-023-01317-7","type":"journal-article","created":{"date-parts":[[2023,8,30]],"date-time":"2023-08-30T09:02:16Z","timestamp":1693386136000},"page":"2393-2400","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Treatment of ankylosing spondylitis with TNF\u03b1 inhibitors does not affect serum levels of tryptophan metabolites"],"prefix":"10.1007","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-2319-8353","authenticated-orcid":false,"given":"Joanna","family":"Witoszy\u0144ska-Sobkowiak","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7326-6916","authenticated-orcid":false,"given":"Dorota","family":"Sikorska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafa\u0142","family":"Rutkowski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karolina","family":"Niklas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iwona","family":"\u017bychowska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0338-894X","authenticated-orcid":false,"given":"W\u0142odzimierz","family":"Samborski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,8,30]]},"reference":[{"issue":"1","key":"1317_CR1","doi-asserted-by":"publisher","first-page":"e000254","DOI":"10.1136\/lupus-2017-000254","volume":"5","author":"K \u00c5kesson","year":"2018","unstructured":"\u00c5kesson K, Pettersson S, St\u00e5hl S, Surowiec I, Hedenstr\u00f6m M, Eketj\u00e4ll S et al (2018) Kynurenine pathway is altered in patients with SLE and associated with severe fatigue. 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