{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T02:12:44Z","timestamp":1791425564558,"version":"4.3.3"},"reference-count":55,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2023,10,17]],"date-time":"2023-10-17T00:00:00Z","timestamp":1697500800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2023,10,17]],"date-time":"2023-10-17T00:00:00Z","timestamp":1697500800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"6 October University"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Inflammopharmacol"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Objective<\/jats:title>\n                <jats:p>Sesamol (SES) is a phenolic compound found in sesame seed oil. Several studies have revealed its anti-inflammatory and antioxidant properties. However, its complete underlying mechanistic perspective about cerebral ischemia\/reperfusion (I\/R) lesions has not yet been disclosed. Consequently, we aimed to scrutinize its neuroprotective mechanism against cerebral injury during a global cerebral I\/R in a rat model, considering its impact on autophagy and Notch1\/NLRP3 inflammasome signaling regulation.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>To affirm our purpose<jats:bold>,<\/jats:bold> adult Wistar rats were allotted into five groups: sham and the other four groups in which transient global cerebral ischemia was induced by bilateral common ligation (2VO) for 1 h, then reperfusion for either 24 h or 5 days: I\/R (1\/24), I\/R (1\/5), SES\u2009+\u2009I\/R (1\/24), and SES\u2009+\u2009I\/R (1\/5). In treated groups, SES (100 mg\/kg, <jats:italic>p.o.<\/jats:italic>, for 21 days) was administered before cerebral I\/R induction. The assessment of histopathological changes in brain tissues, immunohistochemistry, biochemical assays, ELISA, and qRT-PCR were utilized to investigate our hypothesis.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Advantageously, SES halted the structural neuronal damage with lessened demyelination induced by cerebral I\/R injury. Restoring oxidant\/antioxidant balance was evident by boosting the total antioxidant capacity and waning lipid peroxidation. Furthermore, SES reduced inflammatory and apoptosis markers. Additionally, SES recovered GFAP, Cx43, and autophagy signaling, which in turn switched off the Notch-1\/NLRP3 inflammasome trajectory.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>Our results revealed the neuroprotective effect of SES against cerebral I\/R injury through alleviating injurious events and boosting autophagy, consequently abolishing Notch1\/NLRP3 inflammasome signaling.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s10787-023-01355-1","type":"journal-article","created":{"date-parts":[[2023,10,17]],"date-time":"2023-10-17T20:01:50Z","timestamp":1697572910000},"page":"629-642","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Sesamol defends neuronal damage following cerebral ischemia\/reperfusion: a crosstalk of autophagy and Notch1\/NLRP3 inflammasome signaling"],"prefix":"10.1007","volume":"32","author":[{"given":"Shorouk Mohamed","family":"El-Sayyad","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dina M. Abo","family":"El-Ella","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed M.","family":"Hafez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asmaa K.","family":"Al-Mokaddem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bassam Mohamed","family":"Ali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magdy M.","family":"Awny","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3712-4659","authenticated-orcid":false,"given":"Soad Z.","family":"El-Emam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,10,17]]},"reference":[{"key":"1355_CR1","doi-asserted-by":"publisher","first-page":"7501","DOI":"10.2147\/JIR.S342097","volume":"14","author":"L Amalia","year":"2021","unstructured":"Amalia L (2021) Glial fibrillary acidic protein (GFAP): neuroinflammation biomarker in acute ischemic stroke. J Inflamm Res 14:7501\u20137506. https:\/\/doi.org\/10.2147\/JIR.S342097","journal-title":"J Inflamm Res"},{"key":"1355_CR2","volume-title":"Theory and practice of histological techniques","author":"JD Bancroft","year":"2008","unstructured":"Bancroft JD, Gamble M (2008) Theory and practice of histological techniques. Elsevier"},{"key":"1355_CR3","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0153418","author":"HS Basrai","year":"2016","unstructured":"Basrai HS, Christie KJ, Turbic A et al (2016) Suppressor of cytokine signaling-2 (SOCS2) regulates the microglial response and improves functional outcome after traumatic brain injury in mice. PLoS ONE. https:\/\/doi.org\/10.1371\/journal.pone.0153418","journal-title":"PLoS ONE"},{"key":"1355_CR4","doi-asserted-by":"publisher","first-page":"2883","DOI":"10.3892\/MMR.2016.5641\/HTML","volume":"14","author":"Z Cai","year":"2016","unstructured":"Cai Z, Zhao B, Deng Y et al (2016) Notch signaling in cerebrovascular diseases (Review). Mol Med Rep 14:2883\u20132898. https:\/\/doi.org\/10.3892\/MMR.2016.5641\/HTML","journal-title":"Mol Med Rep"},{"key":"1355_CR5","doi-asserted-by":"publisher","DOI":"10.1016\/J.BIOPHA.2022.113587","volume":"154","author":"M Campanile","year":"2022","unstructured":"Campanile M, Cuomo O, Brancaccio P et al (2022) Ruta graveolens water extract (RGWE) ameliorates ischemic damage and improves neurological deficits in a rat model of transient focal brain ischemia. Biomed Pharmacother 154:113587. https:\/\/doi.org\/10.1016\/J.BIOPHA.2022.113587","journal-title":"Biomed Pharmacother"},{"key":"1355_CR6","doi-asserted-by":"publisher","DOI":"10.1016\/J.EXPNEUROL.2019.113117","volume":"324","author":"S Carloni","year":"2020","unstructured":"Carloni S, Balduini W (2020) Simvastatin preconditioning confers neuroprotection against hypoxia-ischemia induced brain damage in neonatal rats via autophagy and silent information regulator 1 (SIRT1) activation. Exp Neurol 324:113117. https:\/\/doi.org\/10.1016\/J.EXPNEUROL.2019.113117","journal-title":"Exp Neurol"},{"key":"1355_CR7","doi-asserted-by":"publisher","first-page":"339","DOI":"10.3389\/FNCEL.2018.00339\/BIBTEX","volume":"12","author":"L Casares-Crespo","year":"2018","unstructured":"Casares-Crespo L, Calatayud-Baselga I, Garc\u00eda-Corzo L, Mira H (2018) On the role of Basal autophagy in adult neural stem cells and neurogenesis. Front Cell Neurosci 12:339. https:\/\/doi.org\/10.3389\/FNCEL.2018.00339\/BIBTEX","journal-title":"Front Cell Neurosci"},{"key":"1355_CR8","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1016\/J.BRAINRES.2012.12.006","volume":"1495","author":"Y Chen","year":"2013","unstructured":"Chen Y, Yi Q, Liu G et al (2013) Cerebral white matter injury and damage to myelin sheath following whole-brain ischemia. Brain Res 1495:11\u201317. https:\/\/doi.org\/10.1016\/J.BRAINRES.2012.12.006","journal-title":"Brain Res"},{"key":"1355_CR9","doi-asserted-by":"publisher","first-page":"2136","DOI":"10.3389\/FCELL.2021.715200\/BIBTEX","volume":"9","author":"S Chen","year":"2021","unstructured":"Chen S, Wang W, Tan HY et al (2021) Role of autophagy in the maintenance of stemness in adult stem cells: a disease-relevant mechanism of action. Front Cell Dev Biol 9:2136. https:\/\/doi.org\/10.3389\/FCELL.2021.715200\/BIBTEX","journal-title":"Front Cell Dev Biol"},{"key":"1355_CR10","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2021.636651","author":"RC Choudhary","year":"2021","unstructured":"Choudhary RC, Shoaib M, Sohnen S et al (2021) Pharmacological approach for neuroprotection after cardiac arrest\u2014a narrative review of current therapies and future neuroprotective cocktail. Front Med. https:\/\/doi.org\/10.3389\/fmed.2021.636651","journal-title":"Front Med"},{"key":"1355_CR11","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1016\/j.ejphar.2005.11.049","volume":"530","author":"M Collino","year":"2006","unstructured":"Collino M, Aragno M, Mastrocola R et al (2006) Modulation of the oxidative stress and inflammatory response by PPAR-\u03b3 agonists in the hippocampus of rats exposed to cerebral ischemia\/reperfusion. Eur J Pharmacol 530:70\u201380. https:\/\/doi.org\/10.1016\/j.ejphar.2005.11.049","journal-title":"Eur J Pharmacol"},{"key":"1355_CR12","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1016\/J.NEUROSCIENCE.2020.05.011","volume":"438","author":"B Du","year":"2020","unstructured":"Du B, Liang M, Zheng H et al (2020) Anti-mouse CX3CR1 antibody alleviates cognitive impairment, neuronal loss and myelin deficits in an animal model of brain ischemia. Neuroscience 438:169\u2013181. https:\/\/doi.org\/10.1016\/J.NEUROSCIENCE.2020.05.011","journal-title":"Neuroscience"},{"key":"1355_CR13","doi-asserted-by":"publisher","DOI":"10.1016\/J.BIOPHA.2022.114075","volume":"157","author":"H Du","year":"2023","unstructured":"Du H, He Y, Zhu J et al (2023) Danhong injection alleviates cerebral ischemia-reperfusion injury by inhibiting mitochondria-dependent apoptosis pathway and improving mitochondrial function in hyperlipidemia rats. Biomed Pharmacother 157:114075. https:\/\/doi.org\/10.1016\/J.BIOPHA.2022.114075","journal-title":"Biomed Pharmacother"},{"key":"1355_CR14","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1016\/J.BBI.2020.12.009","volume":"92","author":"M Franke","year":"2021","unstructured":"Franke M, Bieber M, Kraft P et al (2021) The NLRP3 inflammasome drives inflammation in ischemia\/reperfusion injury after transient middle cerebral artery occlusion in mice. Brain Behav Immun 92:223\u2013233. https:\/\/doi.org\/10.1016\/J.BBI.2020.12.009","journal-title":"Brain Behav Immun"},{"key":"1355_CR15","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1007\/s00011-016-0981-7","volume":"66","author":"L Gao","year":"2017","unstructured":"Gao L, Dong Q, Song Z et al (2017a) NLRP3 inflammasome: a promising target in ischemic stroke. Inflamm Res 66:17\u201324","journal-title":"Inflamm Res"},{"key":"1355_CR16","doi-asserted-by":"publisher","first-page":"841","DOI":"10.3892\/etm.2017.4550","volume":"14","author":"X-J Gao","year":"2017","unstructured":"Gao X-J, Xie G-N, Liu L et al (2017b) Sesamol attenuates oxidative stress, apoptosis and inflammation in focal cerebral ischemia\/reperfusion injury. Exp Ther Med 14:841\u2013847. https:\/\/doi.org\/10.3892\/etm.2017.4550","journal-title":"Exp Ther Med"},{"key":"1355_CR17","doi-asserted-by":"publisher","DOI":"10.1016\/J.JNS.2021.117355","volume":"423","author":"A Genchi","year":"2021","unstructured":"Genchi A, Semerano A, Gullotta GS et al (2021) Cerebral thrombi of cardioembolic etiology have an increased content of neutrophil extracellular traps. J Neurol Sci 423:117355. https:\/\/doi.org\/10.1016\/J.JNS.2021.117355","journal-title":"J Neurol Sci"},{"key":"1355_CR18","doi-asserted-by":"publisher","DOI":"10.1186\/S12974-018-1282-6","author":"Z Gong","year":"2018","unstructured":"Gong Z, Pan J, Shen Q et al (2018) Mitochondrial dysfunction induces NLRP3 inflammasome activation during cerebral ischemia\/reperfusion injury. J Neuroinflammation. https:\/\/doi.org\/10.1186\/S12974-018-1282-6","journal-title":"J Neuroinflammation"},{"key":"1355_CR19","doi-asserted-by":"publisher","DOI":"10.1016\/J.YEXCR.2023.113469","volume":"423","author":"W He","year":"2023","unstructured":"He W, Tong G, Fan H et al (2023) Exendin-4 alleviates myocardial ischemia reperfusion injury by enhancing autophagy through promoting nuclear translocation of TFEB. Exp Cell Res 423:113469. https:\/\/doi.org\/10.1016\/J.YEXCR.2023.113469","journal-title":"Exp Cell Res"},{"key":"1355_CR20","doi-asserted-by":"publisher","DOI":"10.1016\/J.BRAINRES.2022.148132","volume":"1798","author":"Q Hu","year":"2023","unstructured":"Hu Q, Luo L, Yang P et al (2023) Neuroprotection of boropinol-B in cerebral ischemia-reperfusion injury by inhibiting inflammation and apoptosis. Brain Res 1798:148132. https:\/\/doi.org\/10.1016\/J.BRAINRES.2022.148132","journal-title":"Brain Res"},{"key":"1355_CR21","doi-asserted-by":"publisher","DOI":"10.1016\/J.BIOPHA.2019.109452","author":"Z Jin","year":"2019","unstructured":"Jin Z, Guo P, Li X et al (2019) Neuroprotective effects of irisin against cerebral ischemia\/ reperfusion injury via Notch signaling pathway. Biomed Pharmacother. https:\/\/doi.org\/10.1016\/J.BIOPHA.2019.109452","journal-title":"Biomed Pharmacother"},{"key":"1355_CR22","doi-asserted-by":"publisher","first-page":"1245","DOI":"10.1038\/S41423-019-0318-X","volume":"17","author":"Y Jin","year":"2020","unstructured":"Jin Y, Li C, Xu D et al (2020) Jagged1-mediated myeloid Notch1 signaling activates HSF1\/Snail and controls NLRP3 inflammasome activation in liver inflammatory injury. Cell Mol Immunol 17:1245\u20131256. https:\/\/doi.org\/10.1038\/S41423-019-0318-X","journal-title":"Cell Mol Immunol"},{"key":"1355_CR23","doi-asserted-by":"publisher","first-page":"656","DOI":"10.1016\/J.BIOPHA.2018.08.037","volume":"107","author":"R Keowkase","year":"2018","unstructured":"Keowkase R, Shoomarom N, Bunargin W et al (2018) Sesamin and sesamolin reduce amyloid-\u03b2 toxicity in a transgenic Caenorhabditis elegans. Biomed Pharmacother 107:656\u2013664. https:\/\/doi.org\/10.1016\/J.BIOPHA.2018.08.037","journal-title":"Biomed Pharmacother"},{"key":"1355_CR24","doi-asserted-by":"publisher","first-page":"224","DOI":"10.1016\/j.bbamem.2017.03.018","volume":"1860","author":"Y Kim","year":"2018","unstructured":"Kim Y, Davidson JO, Green CR et al (2018) Connexins and pannexins in cerebral ischemia. Biochim Biophys Acta - Biomembr 1860:224\u2013236. https:\/\/doi.org\/10.1016\/j.bbamem.2017.03.018","journal-title":"Biochim Biophys Acta - Biomembr"},{"issue":"13","key":"1355_CR25","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1038\/nri3452","volume":"136","author":"E Latz","year":"2013","unstructured":"Latz E, Xiao TS (2013) Stutz A (2013) Activation and regulation of the inflammasomes. Nat Rev Immunol 136(13):397\u2013411. https:\/\/doi.org\/10.1038\/nri3452","journal-title":"Nat Rev Immunol"},{"key":"1355_CR26","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3390\/IJMS21218050","volume":"21","author":"S Lee","year":"2020","unstructured":"Lee S, Kim SK, Park H et al (2020) Contribution of autophagy-notch1-mediated NLRP3 inflammasome activation to chronic inflammation and fibrosis in keloid fibroblasts. Int J Mol Sci 21:1\u201314. https:\/\/doi.org\/10.3390\/IJMS21218050","journal-title":"Int J Mol Sci"},{"key":"1355_CR27","doi-asserted-by":"publisher","first-page":"703","DOI":"10.3389\/FNEUR.2020.00703\/BIBTEX","volume":"11","author":"Z Liang","year":"2020","unstructured":"Liang Z, Wang X, Hao Y et al (2020) The multifaceted role of astrocyte connexin 43 in ischemic stroke through forming hemichannels and gap junctions. Front Neurol 11:703. https:\/\/doi.org\/10.3389\/FNEUR.2020.00703\/BIBTEX","journal-title":"Front Neurol"},{"issue":"7","key":"1355_CR28","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/srep45728","volume":"71","author":"Z Liu","year":"2017","unstructured":"Liu Z, Ren B, Wang Y et al (2017) Sesamol induces human hepatocellular carcinoma cells apoptosis by impairing mitochondrial function and suppressing autophagy. Sci Rep 71(7):1\u201312. https:\/\/doi.org\/10.1038\/srep45728","journal-title":"Sci Rep"},{"key":"1355_CR29","doi-asserted-by":"publisher","first-page":"11845","DOI":"10.1096\/FJ.201900727R","volume":"33","author":"R Lu","year":"2019","unstructured":"Lu R, Zhang YG, Xia Y, Sun J (2019) Imbalance of autophagy and apoptosis in intestinal epithelium lacking the vitamin D receptor. FASEB J 33:11845\u201311856. https:\/\/doi.org\/10.1096\/FJ.201900727R","journal-title":"FASEB J"},{"key":"1355_CR30","doi-asserted-by":"publisher","DOI":"10.1016\/J.INTIMP.2021.108146","volume":"100","author":"J Luo","year":"2021","unstructured":"Luo J, Chen J, Yang C et al (2021) 6-Gingerol protects against cerebral ischemia\/reperfusion injury by inhibiting NLRP3 inflammasome and apoptosis via TRPV1 \/ FAF1 complex dissociation-mediated autophagy. Int Immunopharmacol 100:108146. https:\/\/doi.org\/10.1016\/J.INTIMP.2021.108146","journal-title":"Int Immunopharmacol"},{"key":"1355_CR31","doi-asserted-by":"publisher","first-page":"728","DOI":"10.1016\/J.CELL.2011.10.026","volume":"147","author":"N Mizushima","year":"2011","unstructured":"Mizushima N, Komatsu M (2011) Autophagy: renovation of cells and tissues. Cell 147:728\u2013741. https:\/\/doi.org\/10.1016\/J.CELL.2011.10.026","journal-title":"Cell"},{"key":"1355_CR32","doi-asserted-by":"publisher","first-page":"1388","DOI":"10.4103\/1673-5374.274331","volume":"15","author":"Y Mo","year":"2020","unstructured":"Mo Y, Sun YY, Liu KY (2020) Autophagy and inflammation in ischemic stroke. Neural Regen Res 15:1388. https:\/\/doi.org\/10.4103\/1673-5374.274331","journal-title":"Neural Regen Res"},{"key":"1355_CR33","doi-asserted-by":"publisher","first-page":"855","DOI":"10.1080\/14728222.2019.1673368","volume":"23","author":"OO Mugisho","year":"2019","unstructured":"Mugisho OO, Rupenthal ID, Paquet-Durand F et al (2019) Targeting connexin hemichannels to control the inflammasome: the correlation between connexin43 and NLRP3 expression in chronic eye disease. Expert Opin Ther Targets 23:855\u2013863. https:\/\/doi.org\/10.1080\/14728222.2019.1673368","journal-title":"Expert Opin Ther Targets"},{"key":"1355_CR34","doi-asserted-by":"publisher","first-page":"182","DOI":"10.1080\/10408363.2019.1575333","volume":"56","author":"SF Nabavi","year":"2019","unstructured":"Nabavi SF, Sureda A, Sanches-Silva A et al (2019) Novel therapeutic strategies for stroke: the role of autophagy. Crit Rev Clin Lab Sci 56:182\u2013199. https:\/\/doi.org\/10.1080\/10408363.2019.1575333","journal-title":"Crit Rev Clin Lab Sci"},{"key":"1355_CR35","doi-asserted-by":"publisher","first-page":"1040","DOI":"10.1097\/00004647-200007000-00003","volume":"20","author":"H Nawashiro","year":"2000","unstructured":"Nawashiro H, Brenner M, Fukui S et al (2000) High Susceptibility to cerebral ischemia in GFAP-null mice. J Cereb Blood Flow Metab 20:1040\u20131044. https:\/\/doi.org\/10.1097\/00004647-200007000-00003","journal-title":"J Cereb Blood Flow Metab"},{"key":"1355_CR36","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1016\/J.EXPNEUROL.2018.02.013","volume":"304","author":"C Ren","year":"2018","unstructured":"Ren C, Yao Y, Han R et al (2018) Cerebral ischemia induces angiogenesis in the peri-infarct regions via Notch1 signaling activation. Exp Neurol 304:30\u201340. https:\/\/doi.org\/10.1016\/J.EXPNEUROL.2018.02.013","journal-title":"Exp Neurol"},{"key":"1355_CR37","doi-asserted-by":"publisher","first-page":"3099","DOI":"10.1021\/ACS.JAFC.9B07598","volume":"68","author":"B Ren","year":"2020","unstructured":"Ren B, Yuan T, Zhang X et al (2020) Protective effects of sesamol on systemic inflammation and cognitive impairment in aging mice. J Agric Food Chem 68:3099\u20133111. https:\/\/doi.org\/10.1021\/ACS.JAFC.9B07598","journal-title":"J Agric Food Chem"},{"key":"1355_CR38","doi-asserted-by":"publisher","first-page":"1393","DOI":"10.1007\/s00134-021-06548-2","volume":"47","author":"C Sandroni","year":"2021","unstructured":"Sandroni C, Cronberg T, Sekhon M (2021) Brain injury after cardiac arrest: pathophysiology, treatment, and prognosis. Intensive Care Med 47:1393\u20131414. https:\/\/doi.org\/10.1007\/s00134-021-06548-2","journal-title":"Intensive Care Med"},{"key":"1355_CR39","doi-asserted-by":"publisher","DOI":"10.1016\/J.PHANU.2020.100217","volume":"14","author":"T Sharma","year":"2020","unstructured":"Sharma T, Airao V, Buch P et al (2020) Sesamol protects hippocampal CA1 neurons and reduces neuronal infarction in global model of cerebral ischemia in rats. PharmaNutrition 14:100217. https:\/\/doi.org\/10.1016\/J.PHANU.2020.100217","journal-title":"PharmaNutrition"},{"key":"1355_CR40","doi-asserted-by":"publisher","DOI":"10.1016\/J.OBMED.2020.100269","volume":"19","author":"TG Singh","year":"2020","unstructured":"Singh TG, Singh HP, Kaur S, Dhiman S (2020) Protective effects of sesamol against cisplatin-induced nephrotoxicity in rats: a mechanistic approach. Obes Med 19:100269. https:\/\/doi.org\/10.1016\/J.OBMED.2020.100269","journal-title":"Obes Med"},{"key":"1355_CR41","doi-asserted-by":"publisher","DOI":"10.3389\/FPHAR.2020.00084","author":"X Sun","year":"2020","unstructured":"Sun X, Wang D, Zhang T et al (2020) Eugenol attenuates cerebral ischemia-reperfusion injury by enhancing autophagy via AMPK-mTOR-P70S6K pathway. Front Pharmacol. https:\/\/doi.org\/10.3389\/FPHAR.2020.00084","journal-title":"Front Pharmacol"},{"key":"1355_CR42","doi-asserted-by":"publisher","first-page":"1384","DOI":"10.3390\/ANTIOX10091384","volume":"10","author":"J Vongsfak","year":"2021","unstructured":"Vongsfak J, Pratchayasakul W, Apaijai N et al (2021) The alterations in mitochondrial dynamics following cerebral ischemia\/reperfusion injury. Antioxidants 10:1384. https:\/\/doi.org\/10.3390\/ANTIOX10091384","journal-title":"Antioxidants"},{"key":"1355_CR43","doi-asserted-by":"publisher","DOI":"10.1016\/J.BIOPHA.2020.110125","author":"X Wang","year":"2020","unstructured":"Wang X, Feng L, Xin M et al (2020) Mechanisms underlying astrocytic connexin-43 autophagy degradation during cerebral ischemia injury and the effect on neuroinflammation and cell apoptosis. Biomed Pharmacother. https:\/\/doi.org\/10.1016\/J.BIOPHA.2020.110125","journal-title":"Biomed Pharmacother"},{"key":"1355_CR44","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.202300012","author":"Y Wang","year":"2023","unstructured":"Wang Y, Zhang Y, Wang X et al (2023) Sesamol mitigates chronic iron overload-induced cognitive impairment and systemic inflammation via IL-6 and DMT1 regulation. Mol Nutr Food Res. https:\/\/doi.org\/10.1002\/mnfr.202300012","journal-title":"Mol Nutr Food Res"},{"key":"1355_CR45","doi-asserted-by":"publisher","first-page":"10533","DOI":"10.1038\/ncomms10533","volume":"7","author":"X Wu","year":"2016","unstructured":"Wu X, Fleming A, Ricketts T et al (2016) Autophagy regulates Notch degradation and modulates stem cell development and neurogenesis. Nat Commun 7:10533. https:\/\/doi.org\/10.1038\/ncomms10533","journal-title":"Nat Commun"},{"key":"1355_CR46","doi-asserted-by":"publisher","first-page":"28","DOI":"10.3389\/FNMOL.2020.00028\/BIBTEX","volume":"13","author":"L Wu","year":"2020","unstructured":"Wu L, Xiong X, Wu X et al (2020) Targeting oxidative stress and inflammation to prevent ischemia-reperfusion injury. Front Mol Neurosci 13:28. https:\/\/doi.org\/10.3389\/FNMOL.2020.00028\/BIBTEX","journal-title":"Front Mol Neurosci"},{"key":"1355_CR47","doi-asserted-by":"publisher","DOI":"10.1016\/J.ENVPOL.2022.120988","volume":"319","author":"J Wu","year":"2023","unstructured":"Wu J, Chen H, Guo T et al (2023) Sesamol alleviates manganese-induced neuroinflammation and cognitive impairment via regulating the microglial cGAS-STING\/NF-\u03baB pathway. Environ Pollut 319:120988. https:\/\/doi.org\/10.1016\/J.ENVPOL.2022.120988","journal-title":"Environ Pollut"},{"key":"1355_CR48","doi-asserted-by":"publisher","first-page":"2865","DOI":"10.1039\/D1FO03888E","volume":"13","author":"B Xia","year":"2022","unstructured":"Xia B, Liu X, Li X et al (2022) Sesamol ameliorates dextran sulfate sodium-induced depression-like and anxiety-like behaviors in colitis mice: the potential involvement of the gut\u2013brain axis. Food Funct 13:2865\u20132883. https:\/\/doi.org\/10.1039\/D1FO03888E","journal-title":"Food Funct"},{"key":"1355_CR49","doi-asserted-by":"publisher","DOI":"10.1016\/J.BMCL.2021.128121","volume":"44","author":"Y Xie","year":"2021","unstructured":"Xie Y, Liu J, Shi Y et al (2021) The combination of sesamol and clofibric acid moieties leads to a novel potent hypolipidemic agent with antioxidant, anti-inflammatory and hepatoprotective activity. Bioorg Med Chem Lett 44:128121. https:\/\/doi.org\/10.1016\/J.BMCL.2021.128121","journal-title":"Bioorg Med Chem Lett"},{"key":"1355_CR50","doi-asserted-by":"publisher","first-page":"996","DOI":"10.1097\/ALN.0B013E31826CB469","volume":"117","author":"Q Yang","year":"2012","unstructured":"Yang Q, Yan W, Li X et al (2012) Activation of canonical notch signaling pathway is involved in the ischemic tolerance induced by sevoflurane preconditioning in mice. Anesthesiology 117:996\u20131005. https:\/\/doi.org\/10.1097\/ALN.0B013E31826CB469","journal-title":"Anesthesiology"},{"key":"1355_CR51","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/S12974-020-01978-Z\/FIGURES\/9","volume":"17","author":"H Yu","year":"2020","unstructured":"Yu H, Cao X, Li W et al (2020) Targeting connexin 43 provides anti-inflammatory effects after intracerebral hemorrhage injury by regulating YAP signaling. J Neuroinflammation 17:1\u201319. https:\/\/doi.org\/10.1186\/S12974-020-01978-Z\/FIGURES\/9","journal-title":"J Neuroinflammation"},{"key":"1355_CR52","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1186\/1471-2105-7-85","volume":"7","author":"JS Yuan","year":"2006","unstructured":"Yuan JS, Reed A, Chen F, Stewart CN (2006) Statistical analysis of real-time PCR data. BMC Bioinformatics 7:85. https:\/\/doi.org\/10.1186\/1471-2105-7-85","journal-title":"BMC Bioinformatics"},{"key":"1355_CR53","doi-asserted-by":"publisher","DOI":"10.1016\/J.BIOPHA.2020.110543","volume":"130","author":"Y Yuan","year":"2020","unstructured":"Yuan Y, Shan X, Men W et al (2020) The effect of crocin on memory, hippocampal acetylcholine level, and apoptosis in a rat model of cerebral ischemia. Biomed Pharmacother 130:110543. https:\/\/doi.org\/10.1016\/J.BIOPHA.2020.110543","journal-title":"Biomed Pharmacother"},{"key":"1355_CR54","doi-asserted-by":"publisher","DOI":"10.1016\/J.BIOPHA.2022.113696","volume":"155","author":"M Zeng","year":"2022","unstructured":"Zeng M, Zhang R, Yang Q et al (2022) Pharmacological therapy to cerebral ischemia-reperfusion injury: focus on saponins. Biomed Pharmacother 155:113696. https:\/\/doi.org\/10.1016\/J.BIOPHA.2022.113696","journal-title":"Biomed Pharmacother"},{"key":"1355_CR55","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/1471-2202-15-25\/TABLES\/6","volume":"15","author":"L Zhao","year":"2014","unstructured":"Zhao L, Guo Y, Ji X, Zhang M (2014) The neuroprotective effect of picroside II via regulating the expression of myelin basic protein after cerebral ischemia injury in rats. BMC Neurosci 15:1\u20139. https:\/\/doi.org\/10.1186\/1471-2202-15-25\/TABLES\/6","journal-title":"BMC Neurosci"}],"container-title":["Inflammopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10787-023-01355-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10787-023-01355-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10787-023-01355-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,2]],"date-time":"2024-03-02T02:38:44Z","timestamp":1709347124000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10787-023-01355-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10,17]]},"references-count":55,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,2]]}},"alternative-id":["1355"],"URL":"https:\/\/doi.org\/10.1007\/s10787-023-01355-1","relation":{},"ISSN":["0925-4692","1568-5608"],"issn-type":[{"value":"0925-4692","type":"print"},{"value":"1568-5608","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,10,17]]},"assertion":[{"value":"16 April 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 September 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 October 2023","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that there are no conflicts of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The ethical approval code is PRE-Ph-230200.4.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"All authors agree to publish.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}}]}}