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Nevertheless, an antifibrotic drug that could suppress the development of hepatic fibrosis does not exist yet. The current study aimed to evaluate the effect of resveratrol, a natural polyphenol with multiple biological activities, on <jats:italic>Schistosoma mansoni<\/jats:italic> (<jats:italic>S. mansoni<\/jats:italic>)-induced hepatic fibrosis and delineate the underlying molecular mechanism. Swiss male albino mice were randomly assigned into infected and non-infected groups. Hepatic schistosomiasis infection was induced via exposure to <jats:italic>S. mansoni<\/jats:italic> cercariae. 6\u00a0weeks later, resveratrol was administrated either as 20\u00a0mg\/kg\/day or 100\u00a0mg\/kg\/day for 4\u00a0weeks to two infected groups. Another group received vehicle and served as infected control group. At the end of the study, portal hemodynamic, biochemical, and histopathological evaluation of liver tissues were conducted. Remarkably, resveratrol significantly reduced portal pressure, portal and mesenteric flow in a dose-dependent manner. It improved several key features of hepatic injury as evidenced biochemically by a significant reduction of bilirubin and liver enzymes, and histologically by amelioration of the granulomatous and inflammatory reactions. In line, resveratrol reduced the expression of pro-inflammatory markers; TNF-\u03b1, IL-1\u03b2 and MCP-1 mRNA, together with fibrotic markers; collagen-1, TGF-\u03b21 and \u03b1-SMA. Moreover, resveratrol restored SIRT1\/NF-\u03baB balance in hepatic tissues which is the main switch-off control for all the fibrotic and inflammatory mechanisms. Taken together, it can be inferred that resveratrol possesses a possible anti-fibrotic effect that can halt the progression of hepatic schistosomiasis via targeting SIRT1\/ NF-\u03baB signaling.<\/jats:p>","DOI":"10.1007\/s10787-023-01382-y","type":"journal-article","created":{"date-parts":[[2023,12,2]],"date-time":"2023-12-02T11:01:49Z","timestamp":1701514909000},"page":"763-775","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Resveratrol protects against Schistosoma mansoni-induced liver fibrosis by targeting the Sirt-1\/NF-\u03baB axis"],"prefix":"10.1007","volume":"32","author":[{"given":"Dalia Kamal","family":"Mostafa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maha M.","family":"Eissa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Doaa A.","family":"Ghareeb","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaymaa","family":"Abdulmalek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8287-4179","authenticated-orcid":false,"given":"Wafaa A.","family":"Hewedy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,12,2]]},"reference":[{"issue":"41","key":"1382_CR1","doi-asserted-by":"publisher","first-page":"6577","DOI":"10.3748\/wjg.v12.i41.6577","volume":"12","author":"JG Abraldes","year":"2006","unstructured":"Abraldes JG, Pasar\u00edn M, Carlos Garc\u00eda-Pag\u00e1n J (2006) Animal models of portal hypertension. 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