{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T03:07:51Z","timestamp":1791256071135,"version":"4.1.0"},"reference-count":83,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2023,12,12]],"date-time":"2023-12-12T00:00:00Z","timestamp":1702339200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2023,12,12]],"date-time":"2023-12-12T00:00:00Z","timestamp":1702339200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Inflammopharmacol"],"published-print":{"date-parts":[[2024,2]]},"DOI":"10.1007\/s10787-023-01392-w","type":"journal-article","created":{"date-parts":[[2023,12,12]],"date-time":"2023-12-12T10:07:45Z","timestamp":1702375665000},"page":"307-317","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Targeting cardiovascular risk factors with eugenol: an anti-inflammatory perspective"],"prefix":"10.1007","volume":"32","author":[{"given":"Sushma","family":"Devi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samrat","family":"Chauhan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashi","family":"Mannan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2979-1590","authenticated-orcid":false,"given":"Thakur Gurjeet","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,12,12]]},"reference":[{"key":"1392_CR1","doi-asserted-by":"publisher","DOI":"10.1007\/s00210-023-02620-4","author":"DH Adeyemi","year":"2023","unstructured":"Adeyemi DH, Obembe OO, Hamed MA, Akhigbe RE (2023) Sodium acetate ameliorates doxorubicin-induced cardiac injury via upregulation of Nrf2\/HO-1 signaling and downregulation of NFkB-mediated apoptotic signaling in Wistar rats. Naunyn Schmiedebergs Arch Pharmacol. https:\/\/doi.org\/10.1007\/s00210-023-02620-4","journal-title":"Naunyn Schmiedebergs Arch Pharmacol"},{"key":"1392_CR2","doi-asserted-by":"publisher","first-page":"3957262","DOI":"10.1155\/2018\/3957262","volume":"2018","author":"JN Barboza","year":"2018","unstructured":"Barboza JN, da Silva-Maia-Bezerra-Filho C, Silva RO et al (2018) An overview on the anti-inflammatory potential and antioxidant profile of eugenol. Oxid Med Cell Longev 2018:3957262. https:\/\/doi.org\/10.1155\/2018\/3957262","journal-title":"Oxid Med Cell Longev"},{"key":"1392_CR3","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2020.110714","volume":"130","author":"T Behl","year":"2020","unstructured":"Behl T, Bungau S, Kumar K et al (2020) Pleotropic effects of polyphenols in cardiovascular system. Biomed Pharmacother 130:110714. https:\/\/doi.org\/10.1016\/j.biopha.2020.110714","journal-title":"Biomed Pharmacother"},{"key":"1392_CR4","doi-asserted-by":"publisher","first-page":"2282","DOI":"10.1021\/acs.jnatprod.1c00386","volume":"84","author":"MI Bittencourt-Mernak","year":"2021","unstructured":"Bittencourt-Mernak MI, Pinheiro NM, da Silva RC et al (2021) Effects of eugenol and dehydrodieugenol b from nectandra leucantha against lipopolysaccharide (LPS)-induced experimental acute lung inflammation. J Nat Prod 84:2282\u20132294. https:\/\/doi.org\/10.1021\/acs.jnatprod.1c00386","journal-title":"J Nat Prod"},{"key":"1392_CR5","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1002\/(SICI)1098-2299(199703)40:3<239::AID-DDR4>3.0.CO;2-L","volume":"40","author":"S-J Chen","year":"1997","unstructured":"Chen S-J, Huang Y-C, Wu B-N, Chen I-J (1997) Eugenolol: an eugenol-derived \u03b2-adrenoceptor blocker with partial \u03b22-agonist and calcium mobilization inhibition associated vasorelaxant activities. Drug Dev Res 40:239\u2013250. https:\/\/doi.org\/10.1002\/(SICI)1098-2299(199703)40:3%3c239::AID-DDR4%3e3.0.CO;2-L","journal-title":"Drug Dev Res"},{"key":"1392_CR6","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1016\/j.brainres.2008.09.030","volume":"1243","author":"JS Cho","year":"2008","unstructured":"Cho JS, Kim TH, Lim J-M, Song J-H (2008) Effects of eugenol on Na+ currents in rat dorsal root ganglion neurons. Brain Res 1243:53\u201362. https:\/\/doi.org\/10.1016\/j.brainres.2008.09.030","journal-title":"Brain Res"},{"key":"1392_CR7","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1007\/s11010-006-2386-3","volume":"283","author":"R Choudhary","year":"2006","unstructured":"Choudhary R, Mishra KP, Subramanyam C (2006) Interrelations between oxidative stress and calcineurin in the attenuation of cardiac apoptosis by eugenol. Mol Cell Biochem 283:115\u2013122. https:\/\/doi.org\/10.1007\/s11010-006-2386-3","journal-title":"Mol Cell Biochem"},{"key":"1392_CR8","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1177\/154405910808700201","volume":"87","author":"G Chung","year":"2008","unstructured":"Chung G, Rhee JN, Jung SJ et al (2008) Modulation of CaV2.3 calcium channel currents by eugenol. J Dent Res 87:137\u2013141. https:\/\/doi.org\/10.1177\/154405910808700201","journal-title":"J Dent Res"},{"key":"1392_CR9","doi-asserted-by":"publisher","first-page":"709","DOI":"10.1007\/s00424-011-1023-5","volume":"462","author":"V Comunanza","year":"2011","unstructured":"Comunanza V, Carbone E, Marcantoni A et al (2011) Calcium-dependent inhibition of T-type calcium channels by TRPV1 activation in rat sensory neurons. Pflugers Arch 462:709\u2013722. https:\/\/doi.org\/10.1007\/s00424-011-1023-5","journal-title":"Pflugers Arch"},{"key":"1392_CR10","doi-asserted-by":"publisher","first-page":"618","DOI":"10.3390\/microorganisms9030618","volume":"9","author":"RA Corb Aron","year":"2021","unstructured":"Corb Aron RA, Abid A, Vesa CM et al (2021) Recognizing the benefits of pre-\/probiotics in metabolic syndrome and type 2 diabetes mellitus considering the influence of akkermansia muciniphila as a key gut bacterium. Microorganisms 9:618. https:\/\/doi.org\/10.3390\/microorganisms9030618","journal-title":"Microorganisms"},{"key":"1392_CR11","doi-asserted-by":"publisher","first-page":"3670","DOI":"10.1016\/j.bbagen.2013.02.008","volume":"1830","author":"GM Cragg","year":"2013","unstructured":"Cragg GM, Newman DJ (2013) Natural products: a continuing source of novel drug leads. Biochim Biophys Acta 1830:3670\u20133695. https:\/\/doi.org\/10.1016\/j.bbagen.2013.02.008","journal-title":"Biochim Biophys Acta"},{"key":"1392_CR12","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1016\/s1537-1891(02)00311-7","volume":"40","author":"CEN Damiani","year":"2003","unstructured":"Damiani CEN, Rossoni LV, Vassallo DV (2003) Vasorelaxant effects of eugenol on rat thoracic aorta. Vascul Pharmacol 40:59\u201366. https:\/\/doi.org\/10.1016\/s1537-1891(02)00311-7","journal-title":"Vascul Pharmacol"},{"key":"1392_CR13","doi-asserted-by":"publisher","DOI":"10.1590\/S0102-695X2009000200006","author":"AN Daniel","year":"2009","unstructured":"Daniel AN, Sartoretto SM, Becerra-Schmidt G et al (2009) Anti-inflammatory and antinociceptive activities A of eugenol essential oil in experimental animal models. Rev Bras. https:\/\/doi.org\/10.1590\/S0102-695X2009000200006","journal-title":"Rev Bras"},{"key":"1392_CR14","doi-asserted-by":"publisher","first-page":"16204","DOI":"10.1038\/s41598-020-73203-z","volume":"10","author":"F das Chagas Pereira de Andrade","year":"2020","unstructured":"das Chagas Pereira de Andrade F, Mendes AN (2020) Computational analysis of eugenol inhibitory activity in lipoxygenase and cyclooxygenase pathways. Sci Rep 10:16204. https:\/\/doi.org\/10.1038\/s41598-020-73203-z","journal-title":"Sci Rep"},{"key":"1392_CR15","doi-asserted-by":"publisher","first-page":"133","DOI":"10.2174\/157489007780832560","volume":"2","author":"S Das","year":"2007","unstructured":"Das S, Das DK (2007) Resveratrol: a therapeutic promise for cardiovascular diseases. Recent Pat Cardiovasc Drug Discov 2:133\u2013138. https:\/\/doi.org\/10.2174\/157489007780832560","journal-title":"Recent Pat Cardiovasc Drug Discov"},{"key":"1392_CR16","doi-asserted-by":"publisher","first-page":"109890","DOI":"10.1016\/j.cbi.2022.109890","volume":"359","author":"DM de Dantas","year":"2022","unstructured":"de Dantas DM, de Silva AA, Pereira-de-Morais L et al (2022) Characterization of the vasodilator effect of eugenol in isolated human umbilical cord arteries. Chemico-Biol Interact 359:109890. https:\/\/doi.org\/10.1016\/j.cbi.2022.109890","journal-title":"Chemico-Biol Interact"},{"key":"1392_CR17","unstructured":"de F\u00e1tima Leal Interaminense de Andrade L (2007) RI UFPE: Estudo dos efeitos cardiovasculares do \u00f3leo essencial do Ocimum gratissimum e de seu principal constituinte, Eugenol, em ratos hipertensos DOCA-sal, acordados"},{"key":"1392_CR18","doi-asserted-by":"publisher","first-page":"645","DOI":"10.1152\/physrev.00026.2014","volume":"95","author":"S Earley","year":"2015","unstructured":"Earley S, Brayden JE (2015) Transient receptor potential channels in the vasculature. Physiol Rev 95:645\u2013690. https:\/\/doi.org\/10.1152\/physrev.00026.2014","journal-title":"Physiol Rev"},{"key":"1392_CR19","doi-asserted-by":"publisher","DOI":"10.3390\/molecules27227893","author":"MF Elsebai","year":"2022","unstructured":"Elsebai MF, Albalawi MA (2022) Essential oils and COVID-19. Molecules. https:\/\/doi.org\/10.3390\/molecules27227893","journal-title":"Molecules"},{"key":"1392_CR20","doi-asserted-by":"publisher","first-page":"567","DOI":"10.1007\/s11418-014-0839-7","volume":"68","author":"CF Estev\u00e3o-Silva","year":"2014","unstructured":"Estev\u00e3o-Silva CF, Kummer R, Fachini-Queiroz FC et al (2014) Anethole and eugenol reduce in vitro and in vivo leukocyte migration induced by fMLP, LTB4, and carrageenan. J Nat Med 68:567\u2013575. https:\/\/doi.org\/10.1007\/s11418-014-0839-7","journal-title":"J Nat Med"},{"key":"1392_CR21","doi-asserted-by":"publisher","first-page":"3464","DOI":"10.3892\/etm.2018.6598","volume":"16","author":"W Feng","year":"2018","unstructured":"Feng W, Jin L, Xie Q et al (2018) Eugenol protects the transplanted heart against ischemia\/reperfusion injury in rats by inhibiting the inflammatory response and apoptosis. Exp Ther Med 16:3464\u20133470. https:\/\/doi.org\/10.3892\/etm.2018.6598","journal-title":"Exp Ther Med"},{"key":"1392_CR22","doi-asserted-by":"publisher","first-page":"209","DOI":"10.3109\/00498259009047156","volume":"20","author":"IU Fischer","year":"1990","unstructured":"Fischer IU, von Unruh GE, Dengler HJ (1990) The metabolism of eugenol in man. Xenobiotica 20:209\u2013222. https:\/\/doi.org\/10.3109\/00498259009047156","journal-title":"Xenobiotica"},{"key":"1392_CR23","doi-asserted-by":"publisher","first-page":"4871","DOI":"10.3390\/nu14224871","volume":"14","author":"AI Foudah","year":"2022","unstructured":"Foudah AI, Devi S, Alqarni MH et al (2022) Quercetin attenuates nitroglycerin-induced migraine headaches by inhibiting oxidative stress and inflammatory mediators. Nutrients 14:4871. https:\/\/doi.org\/10.3390\/nu14224871","journal-title":"Nutrients"},{"key":"1392_CR24","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1016\/s0300-483x(02)00194-4","volume":"177","author":"S Fujisawa","year":"2002","unstructured":"Fujisawa S, Atsumi T, Kadoma Y, Sakagami H (2002) Antioxidant and prooxidant action of eugenol-related compounds and their cytotoxicity. Toxicology 177:39\u201354. https:\/\/doi.org\/10.1016\/s0300-483x(02)00194-4","journal-title":"Toxicology"},{"key":"1392_CR25","doi-asserted-by":"publisher","first-page":"483","DOI":"10.3390\/diagnostics10070483","volume":"10","author":"G Gheorghe","year":"2020","unstructured":"Gheorghe G, Toth PP, Bungau S et al (2020) Cardiovascular risk and statin therapy considerations in women. Diagnostics (basel) 10:483. https:\/\/doi.org\/10.3390\/diagnostics10070483","journal-title":"Diagnostics (basel)"},{"key":"1392_CR26","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1111\/j.1365-2885.2006.00740.x","volume":"29","author":"SA Guenette","year":"2006","unstructured":"Guenette SA, Beaudry F, Marier JF, Vachon P (2006) Pharmacokinetics and anesthetic activity of eugenol in male Sprague-Dawley rats. J Vet Pharmacol Ther 29:265\u2013270. https:\/\/doi.org\/10.1111\/j.1365-2885.2006.00740.x","journal-title":"J Vet Pharmacol Ther"},{"key":"1392_CR27","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1016\/j.ejphar.2007.01.044","volume":"562","author":"SA Gu\u00e9nette","year":"2007","unstructured":"Gu\u00e9nette SA, Ross A, Marier J-F et al (2007) Pharmacokinetics of eugenol and its effects on thermal hypersensitivity in rats. Eur J Pharmacol 562:60\u201367. https:\/\/doi.org\/10.1016\/j.ejphar.2007.01.044","journal-title":"Eur J Pharmacol"},{"key":"1392_CR28","first-page":"46","volume-title":"Handbook of antioxidants","author":"B Halliwell","year":"2001","unstructured":"Halliwell B (2001) Food-derived antioxidants: how to evaluate their importance in food and in vivo. Handbook of antioxidants, 2nd edn. CRC Press, p 46","edition":"2"},{"key":"1392_CR29","doi-asserted-by":"publisher","DOI":"10.1063\/1.5141313","volume":"2199","author":"CD Hamdin","year":"2019","unstructured":"Hamdin CD, Utami SW, Muliasari H et al (2019) Histological pattern on pancreas and liver of diabetic rats after treatment of eugenol isolated from leaves of Syzygium aromaticum. AIP Conf Proc 2199:060004. https:\/\/doi.org\/10.1063\/1.5141313","journal-title":"AIP Conf Proc"},{"key":"1392_CR30","doi-asserted-by":"publisher","first-page":"1619","DOI":"10.1080\/13880209.2017.1314513","volume":"55","author":"X Han","year":"2017","unstructured":"Han X, Parker TL (2017) Anti-inflammatory activity of clove (Eugenia caryophyllata) essential oil in human dermal fibroblasts. Pharm Biol 55:1619\u20131622. https:\/\/doi.org\/10.1080\/13880209.2017.1314513","journal-title":"Pharm Biol"},{"key":"1392_CR31","doi-asserted-by":"publisher","first-page":"14003","DOI":"10.1038\/s41598-019-50352-4","volume":"9","author":"AA Harb","year":"2019","unstructured":"Harb AA, Bustanji YK, Almasri IM, Abdalla SS (2019) Eugenol reduces LDL cholesterol and hepatic steatosis in hypercholesterolemic rats by modulating TRPV1 receptor. Sci Rep 9:14003. https:\/\/doi.org\/10.1038\/s41598-019-50352-4","journal-title":"Sci Rep"},{"key":"1392_CR32","doi-asserted-by":"publisher","first-page":"635","DOI":"10.4236\/ijcm.2015.69084","volume":"06","author":"S Hosseinzadeh","year":"2015","unstructured":"Hosseinzadeh S, Jafarikukhdan A, Hosseini A, Armand R (2015) The application of medicinal plants in traditional and modern medicine: a review of Thymus vulgaris. Int J Clin Med 06:635. https:\/\/doi.org\/10.4236\/ijcm.2015.69084","journal-title":"Int J Clin Med"},{"key":"1392_CR33","doi-asserted-by":"publisher","first-page":"27","DOI":"10.3892\/br.2016.680","volume":"5","author":"G Hu","year":"2016","unstructured":"Hu G, Li X, Zhang S, Wang X (2016) Association of rat thoracic aorta dilatation by astragaloside IV with the generation of endothelium-derived hyperpolarizing factors and nitric oxide, and the blockade of Ca2+ channels. Biomed Rep 5:27\u201334. https:\/\/doi.org\/10.3892\/br.2016.680","journal-title":"Biomed Rep"},{"key":"1392_CR34","doi-asserted-by":"publisher","first-page":"3849","DOI":"10.1039\/D2FO03904D","volume":"14","author":"S Hu","year":"2023","unstructured":"Hu S, Liu B, Yang M et al (2023) Carnosic acid protects against doxorubicin-induced cardiotoxicity through enhancing the Nrf2\/HO-1 pathway. Food Funct 14:3849\u20133862. https:\/\/doi.org\/10.1039\/D2FO03904D","journal-title":"Food Funct"},{"key":"1392_CR35","doi-asserted-by":"publisher","first-page":"906","DOI":"10.1111\/bph.14592","volume":"176","author":"M-Z Huang","year":"2019","unstructured":"Huang M-Z, Yang Y-J, Liu X-W et al (2019) Aspirin eugenol ester attenuates oxidative injury of vascular endothelial cells by regulating NOS and Nrf2 signalling pathways. Br J Pharmacol 176:906\u2013918. https:\/\/doi.org\/10.1111\/bph.14592","journal-title":"Br J Pharmacol"},{"key":"1392_CR36","unstructured":"Hussain S, Rahman R, Mushtaq A, Zerey-Belaskri AE (2017) Clove: a review of a precious species with multiple uses"},{"key":"1392_CR37","doi-asserted-by":"publisher","first-page":"1513","DOI":"10.3390\/biom10111513","volume":"10","author":"S-M Hwang","year":"2020","unstructured":"Hwang S-M, Lee K, Im S-T et al (2020) Co-application of eugenol and QX-314 elicits the prolonged blockade of voltage-gated sodium channels in nociceptive trigeminal ganglion neurons. Biomolecules 10:1513. https:\/\/doi.org\/10.3390\/biom10111513","journal-title":"Biomolecules"},{"key":"1392_CR38","doi-asserted-by":"crossref","unstructured":"Isaksson M, Rustemeyer T, Antelmi A (2020) Dental materials and implants. In: Contact dermatitis. pp 1\u201340","DOI":"10.1007\/978-3-319-72451-5_39-1"},{"key":"1392_CR39","doi-asserted-by":"publisher","first-page":"2208777","DOI":"10.1080\/10641963.2023.2208777","volume":"45","author":"K Jiao","year":"2023","unstructured":"Jiao K, Su P, Li Y (2023) FGFR2 modulates the Akt\/Nrf2\/ARE signaling pathway to improve angiotensin II-induced hypertension-related endothelial dysfunction. Clin Exp Hypertens 45:2208777. https:\/\/doi.org\/10.1080\/10641963.2023.2208777","journal-title":"Clin Exp Hypertens"},{"key":"1392_CR40","doi-asserted-by":"publisher","first-page":"6303","DOI":"10.1021\/jf060608c","volume":"54","author":"L Jirovetz","year":"2006","unstructured":"Jirovetz L, Buchbauer G, Stoilova I et al (2006) Chemical composition and antioxidant properties of clove leaf essential oil. J Agric Food Chem 54:6303\u20136307. https:\/\/doi.org\/10.1021\/jf060608c","journal-title":"J Agric Food Chem"},{"key":"1392_CR41","doi-asserted-by":"publisher","first-page":"1867","DOI":"10.2174\/1381612054021024","volume":"11","author":"GAR Johnston","year":"2005","unstructured":"Johnston GAR (2005) GABA(A) receptor channel pharmacology. Curr Pharm Des 11:1867\u20131885. https:\/\/doi.org\/10.2174\/1381612054021024","journal-title":"Curr Pharm Des"},{"key":"1392_CR42","doi-asserted-by":"crossref","unstructured":"Karuppasamy V, Sekar SK, Kandhasamy S, et al (2022) The anti-integrity activity of eugenol on inflammatory markers of chronic atherosclerosis (In Review)","DOI":"10.21203\/rs.3.rs-1068261\/v3"},{"key":"1392_CR43","doi-asserted-by":"publisher","first-page":"599","DOI":"10.1007\/s13213-010-0092-6","volume":"60","author":"B Kouidhi","year":"2010","unstructured":"Kouidhi B, Zmantar T, Bakhrouf A (2010) Anticariogenic and cytotoxic activity of clove essential oil (Eugenia caryophyllata) against a large number of oral pathogens. Ann Microbiol 60:599\u2013604. https:\/\/doi.org\/10.1007\/s13213-010-0092-6","journal-title":"Ann Microbiol"},{"key":"1392_CR44","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1038\/s41401-022-00942-2","volume":"44","author":"B Kuang","year":"2023","unstructured":"Kuang B, Wang Z, Hou S et al (2023) Methyl eugenol protects the kidney from oxidative damage in mice by blocking the Nrf2 nuclear export signal through activation of the AMPK\/GSK3\u03b2 axis. Acta Pharmacol Sin 44:367\u2013380. https:\/\/doi.org\/10.1038\/s41401-022-00942-2","journal-title":"Acta Pharmacol Sin"},{"key":"1392_CR45","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2020.118661","volume":"264","author":"S Kumar","year":"2021","unstructured":"Kumar S, Behl T, Sachdeva M et al (2021) Implicating the effect of ketogenic diet as a preventive measure to obesity and diabetes mellitus. Life Sci 264:118661. https:\/\/doi.org\/10.1016\/j.lfs.2020.118661","journal-title":"Life Sci"},{"key":"1392_CR46","first-page":"12","volume":"8","author":"R Kummer","year":"2015","unstructured":"Kummer R, Estev\u00e3o-Silva CF, Bastos RL et al (2015) Alpha-pinene reduces in vitro and in vivo leukocyte migration during acute inflammation. Int J Appl Res Nat Prod 8:12\u201317","journal-title":"Int J Appl Res Nat Prod"},{"key":"1392_CR47","doi-asserted-by":"publisher","first-page":"845","DOI":"10.1152\/japplphysiol.00560.2009","volume":"108","author":"CB Magalh\u00e3es","year":"2010","unstructured":"Magalh\u00e3es CB, Riva DR, DePaula LJ et al (2010) In vivo anti-inflammatory action of eugenol on lipopolysaccharide-induced lung injury. J Appl Physiol 108:845\u2013851. https:\/\/doi.org\/10.1152\/japplphysiol.00560.2009","journal-title":"J Appl Physiol"},{"key":"1392_CR48","doi-asserted-by":"publisher","first-page":"668","DOI":"10.1080\/1040841X.2017.1295225","volume":"43","author":"A Marchese","year":"2017","unstructured":"Marchese A, Barbieri R, Coppo E et al (2017) Antimicrobial activity of eugenol and essential oils containing eugenol: a mechanistic viewpoint. Crit Rev Microbiol 43:668\u2013689. https:\/\/doi.org\/10.1080\/1040841X.2017.1295225","journal-title":"Crit Rev Microbiol"},{"key":"1392_CR49","doi-asserted-by":"publisher","first-page":"729","DOI":"10.1016\/0030-4220(92)90020-q","volume":"73","author":"K Markowitz","year":"1992","unstructured":"Markowitz K, Moynihan M, Liu M, Kim S (1992) Biologic properties of eugenol and zinc oxide-eugenol. A clinically oriented review. Oral Surg Oral Med Oral Pathol 73:729\u2013737. https:\/\/doi.org\/10.1016\/0030-4220(92)90020-q","journal-title":"Oral Surg Oral Med Oral Pathol"},{"key":"1392_CR50","doi-asserted-by":"publisher","first-page":"225","DOI":"10.3109\/13813455.2013.822521","volume":"119","author":"K Mnafgui","year":"2013","unstructured":"Mnafgui K, Kaanich F, Derbali A et al (2013) Inhibition of key enzymes related to diabetes and hypertension by eugenol in vitro and in alloxan-induced diabetic rats. Arch Physiol Biochem 119:225\u2013233. https:\/\/doi.org\/10.3109\/13813455.2013.822521","journal-title":"Arch Physiol Biochem"},{"key":"1392_CR51","doi-asserted-by":"publisher","first-page":"201","DOI":"10.4274\/tjps.62207","volume":"14","author":"S Mohammadi Nejad","year":"2017","unstructured":"Mohammadi Nejad S, \u00d6zg\u00fcne\u015f H, Ba\u015faran N (2017) Pharmacological and toxicological properties of eugenol. Turk J Pharm Sci 14:201\u2013206. https:\/\/doi.org\/10.4274\/tjps.62207","journal-title":"Turk J Pharm Sci"},{"key":"1392_CR52","doi-asserted-by":"publisher","first-page":"617","DOI":"10.3109\/10715769509065281","volume":"23","author":"E Nagababu","year":"1995","unstructured":"Nagababu E, Sesikeran B, Lakshmaiah N (1995) The protective effects of eugenol on carbon tetrachloride induced hepatotoxicity in rats. Free Radic Res 23:617\u2013627. https:\/\/doi.org\/10.3109\/10715769509065281","journal-title":"Free Radic Res"},{"key":"1392_CR53","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1007\/978-1-60327-029-8_10","volume":"610","author":"E Nagababu","year":"2010","unstructured":"Nagababu E, Rifkind JM, Boindala S, Nakka L (2010) Assessment of antioxidant activity of eugenol in vitro and in vivo. Methods Mol Biol 610:165\u2013180. https:\/\/doi.org\/10.1007\/978-1-60327-029-8_10","journal-title":"Methods Mol Biol"},{"key":"1392_CR54","doi-asserted-by":"publisher","first-page":"2497354","DOI":"10.1155\/2021\/2497354","volume":"2021","author":"MF Nisar","year":"2021","unstructured":"Nisar MF, Khadim M, Rafiq M et al (2021) Pharmacological properties and health benefits of eugenol: a comprehensive review. Oxid Med Cell Longev 2021:2497354. https:\/\/doi.org\/10.1155\/2021\/2497354","journal-title":"Oxid Med Cell Longev"},{"key":"1392_CR55","doi-asserted-by":"publisher","first-page":"1737","DOI":"10.1177\/00220345970760110401","volume":"76","author":"T Ohkubo","year":"1997","unstructured":"Ohkubo T, Kitamura K (1997) Eugenol activates Ca(2+)-permeable currents in rat dorsal root ganglion cells. J Dent Res 76:1737\u20131744. https:\/\/doi.org\/10.1177\/00220345970760110401","journal-title":"J Dent Res"},{"key":"1392_CR56","doi-asserted-by":"publisher","first-page":"1385","DOI":"10.1007\/s10753-015-0110-8","volume":"38","author":"C Pan","year":"2015","unstructured":"Pan C, Dong Z (2015) Antiasthmatic effects of eugenol in a mouse model of allergic asthma by regulation of vitamin D3 upregulated protein 1\/NF-\u03baB pathway. Inflammation 38:1385\u20131393. https:\/\/doi.org\/10.1007\/s10753-015-0110-8","journal-title":"Inflammation"},{"key":"1392_CR57","doi-asserted-by":"crossref","unstructured":"Parija SC, Jandhyam H, Mohanty BP, et al (2020) Eugenol induces potent vasorelaxation in uterine arteries from pregnant goats\u2014a promising natural therapeutic agent for hypertensive disorders of pregnancy. 2020.09.22.307629","DOI":"10.1101\/2020.09.22.307629"},{"key":"1392_CR58","doi-asserted-by":"publisher","first-page":"889","DOI":"10.1016\/j.ejmech.2018.06.053","volume":"155","author":"RV Patel","year":"2018","unstructured":"Patel RV, Mistry BM, Shinde SK et al (2018) Therapeutic potential of quercetin as a cardiovascular agent. Eur J Med Chem 155:889\u2013904. https:\/\/doi.org\/10.1016\/j.ejmech.2018.06.053","journal-title":"Eur J Med Chem"},{"key":"1392_CR59","first-page":"1999","volume":"5","author":"K Pramod","year":"2010","unstructured":"Pramod K, Ansari SH, Ali J (2010) Eugenol: a natural compound with versatile pharmacological actions. Nat Prod Commun 5:1999\u20132006","journal-title":"Nat Prod Commun"},{"key":"1392_CR60","doi-asserted-by":"publisher","first-page":"623","DOI":"10.13005\/bpj\/2401","volume":"15","author":"J Qar","year":"2022","unstructured":"Qar J, Al-Trad B, Khmaiseh A et al (2022) The effect of eugenol treatment on diabetic cardiomyopathy in streptozotocin-induced diabetic rats. Biomed Pharmacol J 15:623\u2013633","journal-title":"Biomed Pharmacol J"},{"key":"1392_CR61","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1016\/j.lfs.2015.12.043","volume":"145","author":"M Rameshrad","year":"2016","unstructured":"Rameshrad M, Babaei H, Azarmi Y, Fouladi DF (2016) Rat aorta as a pharmacological tool for in vitro and in vivo studies. Life Sci 145:190\u2013204. https:\/\/doi.org\/10.1016\/j.lfs.2015.12.043","journal-title":"Life Sci"},{"key":"1392_CR62","doi-asserted-by":"publisher","DOI":"10.1016\/j.hermed.2021.100430","volume":"27","author":"P Rathod","year":"2021","unstructured":"Rathod P, Yadav RP (2021) Anti-diabesity potential of various multifunctional natural molecules. J Herb Med 27:100430. https:\/\/doi.org\/10.1016\/j.hermed.2021.100430","journal-title":"J Herb Med"},{"key":"1392_CR63","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1080\/14786410802242679","volume":"23","author":"TG Rodrigues","year":"2009","unstructured":"Rodrigues TG, Fernandes A, Sousa JPB et al (2009) In vitro and in vivo effects of clove on pro-inflammatory cytokines production by macrophages. Nat Prod Res 23:319\u2013326. https:\/\/doi.org\/10.1080\/14786410802242679","journal-title":"Nat Prod Res"},{"key":"1392_CR64","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1186\/2008-2231-21-7","volume":"21","author":"A Sankhyan","year":"2013","unstructured":"Sankhyan A, Pawar PK (2013) Metformin loaded non-ionic surfactant vesicles: optimization of formulation, effect of process variables and characterization. Daru 21:7. https:\/\/doi.org\/10.1186\/2008-2231-21-7","journal-title":"Daru"},{"key":"1392_CR65","doi-asserted-by":"publisher","first-page":"S117","DOI":"10.1016\/s0272-6386(00)70239-3","volume":"35","author":"MJ Sarnak","year":"2000","unstructured":"Sarnak MJ, Levey AS (2000) Cardiovascular disease and chronic renal disease: a new paradigm. Am J Kidney Dis 35:S117-131. https:\/\/doi.org\/10.1016\/s0272-6386(00)70239-3","journal-title":"Am J Kidney Dis"},{"key":"1392_CR66","unstructured":"Savsani HH (2020) Pharmacological modulation of calcium in selective cardiovascular disorders through store operated calcium entry inhibitors. Vadodara"},{"key":"1392_CR67","doi-asserted-by":"publisher","first-page":"1089","DOI":"10.1038\/sj.bjp.0703673","volume":"131","author":"O Sensch","year":"2000","unstructured":"Sensch O, Vierling W, Brandt W, Reiter M (2000) Effects of inhibition of calcium and potassium currents in guinea-pig cardiac contraction: comparison of beta-caryophyllene oxide, eugenol, and nifedipine. Br J Pharmacol 131:1089\u20131096. https:\/\/doi.org\/10.1038\/sj.bjp.0703673","journal-title":"Br J Pharmacol"},{"key":"1392_CR68","doi-asserted-by":"publisher","first-page":"314","DOI":"10.1159\/000139248","volume":"49","author":"JN Sharma","year":"1994","unstructured":"Sharma JN, Srivastava KC, Gan EK (1994) Suppressive effects of eugenol and ginger oil on arthritic rats. Pharmacology 49:314\u2013318. https:\/\/doi.org\/10.1159\/000139248","journal-title":"Pharmacology"},{"key":"1392_CR69","doi-asserted-by":"publisher","first-page":"1055","DOI":"10.2174\/1385272826666220620152557","volume":"26","author":"A Singh","year":"2022","unstructured":"Singh A, Singh KS (2022) Bioactive compounds from polar regions: an account of chemical ecology and biotechnological applications. Curr Org Chem 26:1055\u20131087","journal-title":"Curr Org Chem"},{"key":"1392_CR70","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1016\/0952-3278(89)90129-4","volume":"38","author":"KC Srivastava","year":"1989","unstructured":"Srivastava KC, Mustafa T (1989) Spices: antiplatelet activity and prostanoid metabolism. Prostaglandins Leukot Essent Fatty Acids 38:255\u2013266. https:\/\/doi.org\/10.1016\/0952-3278(89)90129-4","journal-title":"Prostaglandins Leukot Essent Fatty Acids"},{"key":"1392_CR71","doi-asserted-by":"publisher","first-page":"123","DOI":"10.2478\/acph-2022-0002","volume":"72","author":"J Tan","year":"2022","unstructured":"Tan J, Yadav MK, Devi S, Kumar M (2022) Neuroprotective effects of arbutin against oxygen and glucose deprivation-induced oxidative stress and neuroinflammation in rat cortical neurons. Acta Pharm 72:123\u2013134. https:\/\/doi.org\/10.2478\/acph-2022-0002","journal-title":"Acta Pharm"},{"key":"1392_CR72","doi-asserted-by":"publisher","DOI":"10.3389\/fvets.2021.628445","volume":"8","author":"LO Tedeschi","year":"2021","unstructured":"Tedeschi LO, Muir JP, Naumann HD et al (2021) Nutritional aspects of ecologically relevant phytochemicals in ruminant production. Front Vet Sci 8:628445. https:\/\/doi.org\/10.3389\/fvets.2021.628445","journal-title":"Front Vet Sci"},{"key":"1392_CR73","doi-asserted-by":"publisher","first-page":"603","DOI":"10.3390\/scipharm84040603","volume":"84","author":"G Thakur","year":"2016","unstructured":"Thakur G, Singh A, Singh I (2016) Chitosan-montmorillonite polymer composites: formulation and evaluation of sustained release tablets of aceclofenac. Sci Pharm 84:603\u2013618. https:\/\/doi.org\/10.3390\/scipharm84040603","journal-title":"Sci Pharm"},{"key":"1392_CR74","doi-asserted-by":"publisher","first-page":"529","DOI":"10.1093\/cvr\/cvy023","volume":"114","author":"RM Touyz","year":"2018","unstructured":"Touyz RM, Alves-Lopes R, Rios FJ et al (2018) Vascular smooth muscle contraction in hypertension. Cardiovasc Res 114:529\u2013539. https:\/\/doi.org\/10.1093\/cvr\/cvy023","journal-title":"Cardiovasc Res"},{"key":"1392_CR75","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2021.e08404","volume":"7","author":"OC Ugbogu","year":"2021","unstructured":"Ugbogu OC, Emmanuel O, Agi GO et al (2021) A review on the traditional uses, phytochemistry, and pharmacological activities of clove basil (Ocimum gratissimum L.). Heliyon 7:e08404. https:\/\/doi.org\/10.1016\/j.heliyon.2021.e08404","journal-title":"Heliyon"},{"key":"1392_CR76","doi-asserted-by":"publisher","first-page":"276","DOI":"10.1016\/j.biopha.2016.03.028","volume":"80","author":"K Venkadeswaran","year":"2016","unstructured":"Venkadeswaran K, Thomas PA, Geraldine P (2016) An experimental evaluation of the anti-atherogenic potential of the plant, Piper betle, and its active constitutent, eugenol, in rats fed an atherogenic diet. Biomed Pharmacother 80:276\u2013288. https:\/\/doi.org\/10.1016\/j.biopha.2016.03.028","journal-title":"Biomed Pharmacother"},{"key":"1392_CR77","doi-asserted-by":"publisher","first-page":"1145","DOI":"10.1016\/j.biopha.2017.08.009","volume":"94","author":"ZW Wong","year":"2017","unstructured":"Wong ZW, Thanikachalam PV, Ramamurthy S (2017) Molecular understanding of the protective role of natural products on isoproterenol-induced myocardial infarction: a review. Biomed Pharmacother 94:1145\u20131166. https:\/\/doi.org\/10.1016\/j.biopha.2017.08.009","journal-title":"Biomed Pharmacother"},{"key":"1392_CR78","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2021.733789","volume":"12","author":"L Xiao-Rong","year":"2021","unstructured":"Xiao-Rong L, Ning M, Xi-Wang L et al (2021) Untargeted and targeted metabolomics reveal the underlying mechanism of aspirin eugenol ester ameliorating rat hyperlipidemia via inhibiting FXR to induce CYP7A1. Front Pharmacol 12:733789. https:\/\/doi.org\/10.3389\/fphar.2021.733789","journal-title":"Front Pharmacol"},{"key":"1392_CR79","doi-asserted-by":"publisher","first-page":"1282","DOI":"10.1053\/j.gastro.2007.06.015","volume":"133","author":"G-Y Xu","year":"2007","unstructured":"Xu G-Y, Winston JH, Shenoy M et al (2007) Transient receptor potential vanilloid 1 mediates hyperalgesia and is up-regulated in rats with chronic pancreatitis. Gastroenterology 133:1282\u20131292. https:\/\/doi.org\/10.1053\/j.gastro.2007.06.015","journal-title":"Gastroenterology"},{"key":"1392_CR80","doi-asserted-by":"publisher","first-page":"738","DOI":"10.1038\/nm1758","volume":"14","author":"S Yamamoto","year":"2008","unstructured":"Yamamoto S, Shimizu S, Kiyonaka S et al (2008) TRPM2-mediated Ca2+ influx induces chemokine production in monocytes that aggravates inflammatory neutrophil infiltration. Nat Med 14:738\u2013747. https:\/\/doi.org\/10.1038\/nm1758","journal-title":"Nat Med"},{"key":"1392_CR81","doi-asserted-by":"publisher","first-page":"781","DOI":"10.1177\/154405910308201004","volume":"82","author":"BH Yang","year":"2003","unstructured":"Yang BH, Piao ZG, Kim Y-B et al (2003) Activation of vanilloid receptor 1 (VR1) by eugenol. J Dent Res 82:781\u2013785. https:\/\/doi.org\/10.1177\/154405910308201004","journal-title":"J Dent Res"},{"key":"1392_CR82","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1177\/039463201102400208","volume":"24","author":"JL Yeh","year":"2011","unstructured":"Yeh JL, Hsu JH, Hong YS et al (2011) Eugenolol and glyceryl-isoeugenol suppress LPS-induced iNOS expression by down-regulating NF-kappaB AND AP-1 through inhibition of MAPKS and AKT\/IkappaBalpha signaling pathways in macrophages. Int J Immunopathol Pharmacol 24:345\u2013356. https:\/\/doi.org\/10.1177\/039463201102400208","journal-title":"Int J Immunopathol Pharmacol"},{"key":"1392_CR83","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1016\/j.tox.2009.12.018","volume":"268","author":"B Yogalakshmi","year":"2010","unstructured":"Yogalakshmi B, Viswanathan P, Anuradha CV (2010) Investigation of antioxidant, anti-inflammatory and DNA-protective properties of eugenol in thioacetamide-induced liver injury in rats. Toxicology 268:204\u2013212. https:\/\/doi.org\/10.1016\/j.tox.2009.12.018","journal-title":"Toxicology"}],"container-title":["Inflammopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10787-023-01392-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10787-023-01392-w\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10787-023-01392-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,2]],"date-time":"2024-03-02T02:47:31Z","timestamp":1709347651000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10787-023-01392-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12,12]]},"references-count":83,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,2]]}},"alternative-id":["1392"],"URL":"https:\/\/doi.org\/10.1007\/s10787-023-01392-w","relation":{},"ISSN":["0925-4692","1568-5608"],"issn-type":[{"value":"0925-4692","type":"print"},{"value":"1568-5608","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,12,12]]},"assertion":[{"value":"27 July 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 November 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 December 2023","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"There are no conflicts of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"The paper is submitted with the consent of all listed authors.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to Publish"}},{"value":"Not applicable.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"Not applicable.","order":6,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}}]}}