{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T00:25:15Z","timestamp":1774311915428,"version":"3.50.1"},"reference-count":36,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2024,2,17]],"date-time":"2024-02-17T00:00:00Z","timestamp":1708128000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,2,17]],"date-time":"2024-02-17T00:00:00Z","timestamp":1708128000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Inflammopharmacol"],"published-print":{"date-parts":[[2024,4]]},"DOI":"10.1007\/s10787-024-01430-1","type":"journal-article","created":{"date-parts":[[2024,2,17]],"date-time":"2024-02-17T16:02:27Z","timestamp":1708185747000},"page":"1187-1201","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Ameliorative effects of Atriplex crassifolia (C.A.Mey) on pain and inflammation through modulation of inflammatory biomarkers and GC\u2013MS-based metabolite profiling"],"prefix":"10.1007","volume":"32","author":[{"given":"Sarah","family":"Rehman","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1749-1956","authenticated-orcid":false,"given":"Saiqa","family":"Ishtiaq","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muhammad","family":"Khalil-Ur-Rehman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sairah Hafeez","family":"Kamran","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,2,17]]},"reference":[{"key":"1430_CR1","first-page":"75","volume":"5","author":"Q Abbas","year":"2014","unstructured":"Abbas Q, Khan SW, Khatoon S, Hussain SA, Hassan SN, Hussain A, Qureshi R, Hussain I (2014) Floristic biodiversity and traditional uses of medicinal plants of Haramosh valley Central Karakoram National Park of Gilgit district. Gilgit-Baltistan Pakistan J Bio Env Sci 5:75\u201386","journal-title":"Gilgit-Baltistan Pakistan J Bio Env Sci"},{"issue":"6","key":"1430_CR2","first-page":"81","volume":"8","author":"AE Al-Snafi","year":"2018","unstructured":"Al-Snafi AE (2018) Arabian medicinal plants with analgesic and antipyretic effects-plant based review (Part 1). IOSR J Pharm 8(6):81\u2013102","journal-title":"IOSR J Pharm"},{"issue":"3","key":"1430_CR3","doi-asserted-by":"publisher","first-page":"454","DOI":"10.1016\/j.jep.2007.12.008","volume":"116","author":"G Amresh","year":"2018","unstructured":"Amresh G, Singh PN, Rao CV (2018) Toxicological screening of traditional medicine Laghupatha (Cissampelos pareira) in experimental animals. J Ethnopharmacol 116(3):454\u2013460. https:\/\/doi.org\/10.1016\/j.jep.2007.12.008","journal-title":"J Ethnopharmacol"},{"key":"1430_CR4","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s40816-019-0137-8","volume":"5","author":"GN Anyasor","year":"2019","unstructured":"Anyasor GN, Okanlawon AA, Ogunbiyi B (2019) Evaluation of anti-inflammatory activity of Justicia secunda Vahl leaf extract using in vitro and in vivo inflammation models. Clin Phytoscience 5:1\u20133","journal-title":"Clin Phytoscience"},{"issue":"3","key":"1430_CR5","doi-asserted-by":"publisher","first-page":"434","DOI":"10.1111\/j.1747-0285.2012.01418.x","volume":"80","author":"V Aparna","year":"2012","unstructured":"Aparna V, Dileep KV, Mandal PK, Karthe P, Sadasivan C, Haridas M (2012) Anti-inflammatory property of n-hexadecanoic acid: structural evidence and kinetic assessment. Chem Biol Drug Des 80(3):434\u2013439. https:\/\/doi.org\/10.1111\/j.1747-0285.2012.01418.x","journal-title":"Chem Biol Drug Des"},{"key":"1430_CR6","first-page":"1","volume":"3","author":"A Asif","year":"2023","unstructured":"Asif A, Ishtiaq S, Kamran SH, Waseem R, Fatima SF, Rehman S (2023) UHPLC\u2013MS and GC\u2013MS phytochemical profiling, amelioration of pain and inflammation with chloroform extract of Funaria hygrometrica Hedw. via modulation of inflammatory biomarkers. Inflammopharmacology 3:1\u20134","journal-title":"Inflammopharmacology"},{"issue":"1","key":"1430_CR7","first-page":"33","volume":"3","author":"M Biswas","year":"2011","unstructured":"Biswas M, Biswas K, Karan TK, Bhattacharya S, Ghosh AK, Haldar PK (2011) Evaluation of analgesic and anti-inflammatory activities of Terminalia arjuna leaf. J Phytol 3(1):33\u201338","journal-title":"J Phytol"},{"issue":"1","key":"1430_CR8","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1016\/j.jpha.2021.07.004","volume":"12","author":"A Bouyahya","year":"2022","unstructured":"Bouyahya A, Guaouguaou FE, El Omari N, El Menyiy N, Balahbib A, El-Shazly M, Bakri Y (2022) Anti-inflammatory and analgesic properties of Moroccan medicinal plants: Phytochemistry, in vitro and in vivo investigations, mechanism insights, clinical evidences and perspectives. J Pharm Anal 12(1):35\u201357. https:\/\/doi.org\/10.1016\/j.jpha.2021.07.004","journal-title":"J Pharm Anal"},{"issue":"1\u20132","key":"1430_CR9","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1016\/j.vetimm.2012.08.002","volume":"150","author":"M Caroprese","year":"2012","unstructured":"Caroprese M, Albenzio M, Ciliberti MG, Francavilla M, Sevi A (2012) A mixture of phytosterols from Dunaliella tertiolecta affects proliferation of peripheral blood mononuclear cells and cytokine production in sheep. Vet Immunol Immunopathol 150(1\u20132):27\u201335. https:\/\/doi.org\/10.1016\/j.vetimm.2012.08.002","journal-title":"Vet Immunol Immunopathol"},{"key":"1430_CR11","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodres.2020.109975","volume":"140","author":"X Fan","year":"2021","unstructured":"Fan X, Jiao X, Liu J, Jia M, Blanchard C, Zhou Z (2021) Characterizing the volatile compounds of different sorghum cultivars by both GC-MS and HS-GC-IMS. Food Res Int 140:109975. https:\/\/doi.org\/10.1016\/j.foodres.2020.109975","journal-title":"Food Res Int"},{"issue":"2","key":"1430_CR12","doi-asserted-by":"publisher","first-page":"142","DOI":"10.3329\/bjp.v13i2.33313","volume":"13","author":"UH Hasan","year":"2018","unstructured":"Hasan UH (2018) Antiarthritic efficacy of Clematis orientalis. Bangladesh J Pharmacol 13(2):142\u2013148. https:\/\/doi.org\/10.3329\/bjp.v13i2.33313","journal-title":"Bangladesh J Pharmacol"},{"key":"1430_CR13","doi-asserted-by":"publisher","first-page":"112966","DOI":"10.1016\/j.jep.2020.112966","volume":"259","author":"F Javed","year":"2020","unstructured":"Javed F, Jabeen Q, Aslam N, Awan AM (2020) Pharmacological evaluation of analgesic, anti-inflammatory and antipyretic activities of ethanolic extract of Indigofera argentea Burm. f. J Ethnopharmacol 259:112966","journal-title":"J Ethnopharmacol"},{"key":"1430_CR14","unstructured":"Jin F.\u00a0(2012) The pharmaceutical potential of compounds from Tasmanian Clematis species. Doctoral dissertation, University of Tasmania"},{"issue":"1","key":"1430_CR15","first-page":"123","volume":"2","author":"NA John","year":"2012","unstructured":"John NA, Shobana G (2012) Anti-inflammatory activity of Talinum fruticosum l. on formalin induced paw edema in albino rats. J Appl Pharm Sci 2(1):123\u2013127","journal-title":"J Appl Pharm Sci"},{"issue":"14","key":"1430_CR16","doi-asserted-by":"publisher","first-page":"1551","DOI":"10.2174\/1381612824666180403122003","volume":"24","author":"S Kazemi","year":"2014","unstructured":"Kazemi S, Shirzad H, Rafieian-Kopaei M (2014) Recent findings in molecular basis of inflammation and anti-inflammatory plants. Curr Pharm Des 24(14):1551\u20131562. https:\/\/doi.org\/10.2174\/1381612824666180403122003","journal-title":"Curr Pharm Des"},{"key":"1430_CR17","doi-asserted-by":"publisher","first-page":"1597","DOI":"10.1007\/s11250-017-1364-y","volume":"49","author":"BA Lone","year":"2017","unstructured":"Lone BA, Chishti MZ, Bhat FA, Tak H, Bandh SA, Khan A (2017) Evaluation of anthelmintic antimicrobial and antioxidant activity of Chenopodium album. Trop Anim Health Prod 49:1597\u20131605. https:\/\/doi.org\/10.1007\/s11250-017-1364-y","journal-title":"Trop Anim Health Prod"},{"issue":"12","key":"1430_CR18","doi-asserted-by":"publisher","first-page":"1343","DOI":"10.1080\/14786419.2015.1062761","volume":"30","author":"F Maione","year":"2016","unstructured":"Maione F, Russo R, Khan H, Mascolo N (2016) Medicinal plants with anti-inflammatory activities. Nat Prod Res 30(12):1343\u20131352","journal-title":"Nat Prod Res"},{"issue":"7203","key":"1430_CR19","doi-asserted-by":"publisher","first-page":"428","DOI":"10.1038\/nature07201","volume":"454","author":"R Medzhitov","year":"2008","unstructured":"Medzhitov R (2008) Origin and physiological roles of inflammation. Nature 454(7203):428\u2013435. https:\/\/doi.org\/10.1038\/nature07201","journal-title":"Nature"},{"issue":"1","key":"1430_CR20","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1093\/rheumatology\/ken395","volume":"48","author":"F Montecucco","year":"2009","unstructured":"Montecucco F, Mach F (2009) Common inflammatory mediators orchestrate pathophysiological processes in rheumatoid arthritis and atherosclerosis. Rheumatology 48(1):11\u201322. https:\/\/doi.org\/10.1093\/rheumatology\/ken395","journal-title":"Rheumatology"},{"key":"1430_CR21","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2014\/810615","volume":"2014","author":"K Mubashir","year":"2014","unstructured":"Mubashir K, Ganai BA, Ghazanfar K, Akbar S (2014) Evaluation of antiarthritic potential of methanolic extract of Gentiana kurroo Royle. Arthritis 2014:1\u20136. https:\/\/doi.org\/10.1155\/2014\/810615","journal-title":"Arthritis"},{"key":"1430_CR22","doi-asserted-by":"publisher","first-page":"109753","DOI":"10.1016\/j.biopha.2019.109753","volume":"123","author":"T Nguyen","year":"2020","unstructured":"Nguyen T, Chen X, Chai J, Li R, Han X, Chen X, Liu S, Chen M, Xu X (2020) Antipyretic, anti-inflammatory and analgesic activities of Periplaneta americana extract and underlying mechanisms. Biomed Pharmacother 123:109753. https:\/\/doi.org\/10.1016\/j.biopha.2019.109753","journal-title":"Biomed Pharmacother"},{"key":"1430_CR23","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1007\/s10787-009-0010-3","volume":"17","author":"J Niazi","year":"2009","unstructured":"Niazi J, Singh P, Bansal Y, Goel RK (2009) Anti-inflammatory, analgesic and antipyretic activity of aqueous extract of fresh leaves of Coccinia indica. Inflammopharmacol 17:239\u2013244. https:\/\/doi.org\/10.1007\/s10787-009-0010-3","journal-title":"Inflammopharmacol"},{"issue":"11","key":"1430_CR25","doi-asserted-by":"publisher","first-page":"1478","DOI":"10.3109\/13880209.2014.898078","volume":"52","author":"NN Okoye","year":"2014","unstructured":"Okoye NN, Ajaghaku DL, Okeke HN, Ilodigwe EE, Nworu CS, Okoye FB (2014) Beta-Amyrin and alpha-amyrin acetate isolated from the stem bark of Alstonia boonei display profound anti-inflammatory activity. Pharm Biol 52(11):1478\u20131486. https:\/\/doi.org\/10.3109\/13880209.2014.898078","journal-title":"Pharm Biol"},{"issue":"3","key":"1430_CR27","doi-asserted-by":"publisher","first-page":"2379","DOI":"10.1021\/acsomega.0c05698","volume":"6","author":"S Qasim","year":"2021","unstructured":"Qasim S, Alamgeer SM, Alotaibi NH, Bukhari SN, Alharbi KS, Irfan HM, Anwar R (2021) Appraisal of the antiarthritic potential of prazosin via inhibition of proinflammatory cytokine TNF-\u03b1: a key player in rheumatoid arthritis. ACS Omega 6(3):2379\u20132388. https:\/\/doi.org\/10.1021\/acsomega.0c05698","journal-title":"ACS Omega"},{"issue":"1","key":"1430_CR28","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1007\/s13596-019-00404-x","volume":"20","author":"M Rajamanickam","year":"2020","unstructured":"Rajamanickam M, Rajamohan S (2020) Analgesic activity of flavonoids isolated from Persicaria glabra (wild). Adv Tradit Med 20(1):71\u201376. https:\/\/doi.org\/10.1007\/s13596-019-00404-x","journal-title":"Adv Tradit Med"},{"key":"1430_CR29","unstructured":"Ratheesh M, Helen A (2007) Anti-inflammatory activity of Ruta graveolens Linn on carrageenan induced paw edema in wistar male rats. Afr J Biotechnol 6(10). eISSN: 1684\u20135315"},{"issue":"18","key":"1430_CR30","doi-asserted-by":"publisher","first-page":"1775","DOI":"10.1080\/14786419.2014.999336","volume":"29","author":"A Rauf","year":"2015","unstructured":"Rauf A, Khan R, Khan H, Tokuda H (2015) Cytotoxic, antitumour-promoting and inhibition of protein denaturation effects of flavonoids, isolated from Potentilla evestita Th. Wolf Nat Prod Res 29(18):1775\u20131778. https:\/\/doi.org\/10.1080\/14786419.2014.999336","journal-title":"Wolf Nat Prod Res"},{"issue":"6","key":"1430_CR31","doi-asserted-by":"publisher","first-page":"429","DOI":"10.52711\/0974-4150.2022.00075","volume":"15","author":"SA Rokade","year":"2022","unstructured":"Rokade SA, Jadhav RV (2022) Review on analgesic activity using tail immersion method. Asian J Res Chem 15(6):429\u2013432. https:\/\/doi.org\/10.52711\/0974-4150.2022.00075","journal-title":"Asian J Res Chem"},{"issue":"5","key":"1430_CR32","doi-asserted-by":"publisher","first-page":"24","DOI":"10.21010\/ajtcam.v14i5.4","volume":"14","author":"A Saleem","year":"2017","unstructured":"Saleem A, Javeed A, Ashraf M, Akhtar MF, Akhtar B, Sharif A, Akhtar K, Raza M, Hamid I, Peerzada S, Ahmad S (2017) Anti-inflammatory, anti-nociceptive and antipyretic potential of Terminalia citrina fruit extracts. Afr J Tradit Complement Altern Med 14(5):24\u201330. https:\/\/doi.org\/10.21010\/ajtcam.v14i5.4","journal-title":"Afr J Tradit Complement Altern Med"},{"issue":"31","key":"1430_CR100","first-page":"1167","volume":"3","author":"A Saleem","year":"2019","unstructured":"Saleem A, Saleem M, Akhtar MF, Sharif A, Javaid Z, Sohail K (2019) In vitro and in vivo anti-arthritic evaluation of Polystichum braunii to validate its folkloric claim. Pak J Pharm Sci 3(32):1167\u20131173","journal-title":"Pak J Pharm Sci"},{"key":"1430_CR33","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1016\/j.ejphar.2014.05.045","volume":"738","author":"A Shabbir","year":"2014","unstructured":"Shabbir A, Shahzad M, Ali A, Zia-ur-Rehman M (2014) Anti-arthritic activity of N\u2032-[(2, 4-dihydroxyphenyl) methylidene]-2-(3, 4-dimethyl-5, 5-dioxidopyrazolo [4, 3-c][1, 2] benzothiazin-1 (4H)-yl) acetohydrazide. Eur J Pharmacol 738:263\u2013272. https:\/\/doi.org\/10.1016\/j.ejphar.2014.05.045","journal-title":"Eur J Pharmacol"},{"issue":"4","key":"1430_CR34","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1111\/fcp.12049","volume":"28","author":"RO Silva","year":"2014","unstructured":"Silva RO, Sousa FB, Damasceno SR, Carvalho NS, Silva VG, Oliveira FR, Sousa DP, Arag\u00e3o KS, Barbosa AL, Freitas RM, Medeiros JV (2014) Phytol, a diterpene alcohol, inhibits the inflammatory response by reducing cytokine production and oxidative stress. Fundam Clin Pharmacol 28(4):455\u2013464. https:\/\/doi.org\/10.1111\/fcp.12049","journal-title":"Fundam Clin Pharmacol"},{"issue":"1","key":"1430_CR35","doi-asserted-by":"publisher","first-page":"3","DOI":"10.3126\/jbs.v4i1.20572","volume":"4","author":"VB Tatipamula","year":"2017","unstructured":"Tatipamula VB, Vedula GS (2017) Anti-inflammatory properties of Dirinaria consimilis extracts in albino rats. J Biomed Sci 4(1):3\u20138. https:\/\/doi.org\/10.3126\/jbs.v4i1.20572","journal-title":"J Biomed Sci"},{"issue":"4","key":"1430_CR36","doi-asserted-by":"publisher","first-page":"636","DOI":"10.1016\/S0254-6272(18)30897-5","volume":"38","author":"AM Uttra","year":"2018","unstructured":"Uttra AM, Ahsan H, Hasan UH, Chaudhary MA (2018) Traditional medicines of plant origin used for the treatment of inflammatory disorders in Pakistan: a review. J Tradit Chin Med 38(4):636\u2013656. https:\/\/doi.org\/10.1016\/S0254-6272(18)30897-5","journal-title":"J Tradit Chin Med"},{"issue":"8","key":"1430_CR37","doi-asserted-by":"publisher","first-page":"4334","DOI":"10.1016\/j.sjbs.2021.04.020","volume":"28","author":"S Wahid","year":"2021","unstructured":"Wahid S, Alqahtani A, Khan RA (2021) Analgesic and anti-inflammatory effects and safety profile of Cucurbita maxima and Cucumis sativus seeds. Saudi J Biol Sci 28(8):4334\u20134341. https:\/\/doi.org\/10.1016\/j.sjbs.2021.04.020","journal-title":"Saudi J Biol Sci"},{"issue":"1","key":"1430_CR39","doi-asserted-by":"publisher","first-page":"502","DOI":"10.1021\/acsnano.1c07556","volume":"16","author":"H Yu","year":"2021","unstructured":"Yu H, Fan J, Shehla N, Qiu Y, Lin Y, Wang Z, Cao L, Li B, Daniyal M, Qin Y, Peng C (2021) Biomimetic hybrid membrane-coated xuetongsu assisted with laser irradiation for efficient rheumatoid arthritis therapy. ACS Nano 16(1):502\u2013521. https:\/\/doi.org\/10.1021\/acsnano.1c07556","journal-title":"ACS Nano"}],"container-title":["Inflammopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10787-024-01430-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10787-024-01430-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10787-024-01430-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,10]],"date-time":"2024-04-10T13:32:06Z","timestamp":1712755926000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10787-024-01430-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2,17]]},"references-count":36,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2024,4]]}},"alternative-id":["1430"],"URL":"https:\/\/doi.org\/10.1007\/s10787-024-01430-1","relation":{},"ISSN":["0925-4692","1568-5608"],"issn-type":[{"value":"0925-4692","type":"print"},{"value":"1568-5608","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,2,17]]},"assertion":[{"value":"16 September 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 January 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 February 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors have not disclosed any competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"All data generated or investigated in the study are included in this article.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Data availability"}}]}}