{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T03:47:03Z","timestamp":1784864823143,"version":"3.55.0"},"reference-count":117,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2024,5,9]],"date-time":"2024-05-09T00:00:00Z","timestamp":1715212800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,5,9]],"date-time":"2024-05-09T00:00:00Z","timestamp":1715212800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/100014718","name":"Innovative Research Group Project of the National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82173462"],"award-info":[{"award-number":["82173462"]}],"id":[{"id":"10.13039\/100014718","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014718","name":"Innovative Research Group Project of the National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81972968"],"award-info":[{"award-number":["81972968"]}],"id":[{"id":"10.13039\/100014718","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Inflammopharmacol"],"published-print":{"date-parts":[[2024,8]]},"DOI":"10.1007\/s10787-024-01485-0","type":"journal-article","created":{"date-parts":[[2024,5,9]],"date-time":"2024-05-09T13:01:47Z","timestamp":1715259707000},"page":"2203-2217","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Monomeric compounds from natural products for the treatment of pulmonary fibrosis: a review"],"prefix":"10.1007","volume":"32","author":[{"given":"Zhuqing","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanyong","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9792-8248","authenticated-orcid":false,"given":"Fu","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,5,9]]},"reference":[{"key":"1485_CR1","doi-asserted-by":"publisher","first-page":"1857","DOI":"10.3390\/ijms24031857","volume":"24","author":"J Adamcakova","year":"2023","unstructured":"Adamcakova J, Balentova S, Barosova R, Hanusrichterova J, Mikolka P, Prso K, Mokry J, Tatarkova Z, Kalenska D, Mokra D (2023) Effects of green tea polyphenol epigallocatechin-3-gallate on markers of inflammation and fibrosis in a rat model of pulmonary silicosis. Int J Mol Sci 24:1857","journal-title":"Int J Mol Sci"},{"key":"1485_CR2","doi-asserted-by":"publisher","first-page":"1402","DOI":"10.1007\/s10753-012-9453-6","volume":"35","author":"Y Agackiran","year":"2012","unstructured":"Agackiran Y, Gul H, Gunay E, Akyurek N, Memis L, Gunay S, Sirin YS, Ide T (2012) The efficiency of proanthocyanidin in an experimental pulmonary fibrosis model: comparison with taurine. Inflammation 35:1402\u20131410","journal-title":"Inflammation"},{"key":"1485_CR3","doi-asserted-by":"publisher","first-page":"109568","DOI":"10.1016\/j.cbi.2021.109568","volume":"345","author":"KS Alharbi","year":"2021","unstructured":"Alharbi KS, Fuloria NK, Fuloria S, Rahman SB, Al-Malki WH, Javed S, Thangavelu L, Singh SK, Rama RA, Jha NK, Chellappan DK, Dua K, Gupta G (2021) Nuclear factor-kappa B and its role in inflammatory lung disease. Chem Biol Interact 345:109568","journal-title":"Chem Biol Interact"},{"key":"1485_CR4","doi-asserted-by":"publisher","first-page":"886","DOI":"10.1007\/s10753-018-0743-5","volume":"41","author":"J Ameeramja","year":"2018","unstructured":"Ameeramja J, Perumal E (2018) Possible modulatory effect of tamarind seed coat extract on fluoride-induced pulmonary inflammation and fibrosis in rats. Inflammation 41:886\u2013895","journal-title":"Inflammation"},{"key":"1485_CR5","doi-asserted-by":"publisher","first-page":"1831","DOI":"10.1089\/ars.2018.7569","volume":"30","author":"L An","year":"2019","unstructured":"An L, Peng LY, Sun NY, Yang YL, Zhang XW, Li B, Liu BL, Li P, Chen J (2019) Tanshinone IIA activates nuclear factor-erythroid 2-related factor 2 to restrain pulmonary fibrosis via regulation of redox homeostasis and glutaminolysis. Antioxid Redox Signal 30:1831\u20131848","journal-title":"Antioxid Redox Signal"},{"key":"1485_CR6","doi-asserted-by":"publisher","first-page":"715","DOI":"10.3389\/fphar.2019.00715","volume":"10","author":"L Avila-Carrasco","year":"2019","unstructured":"Avila-Carrasco L, Majano P, Sanchez-Tomero JA, Selgas R, Lopez-Cabrera M, Aguilera A, Gonzalez MG (2019) Natural plants compounds as modulators of epithelial-to-mesenchymal transition. Front Pharmacol 10:715","journal-title":"Front Pharmacol"},{"key":"1485_CR7","doi-asserted-by":"publisher","first-page":"119","DOI":"10.3390\/antiox9020119","volume":"9","author":"T Bacchetti","year":"2020","unstructured":"Bacchetti T, Morresi C, Bellachioma L, Ferretti G (2020) Antioxidant and pro-oxidant properties of carthamus tinctorius, hydroxy safflor yellow A, and safflor yellow A. Antioxidants 9:119","journal-title":"Antioxidants"},{"key":"1485_CR8","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1183\/09059180.00001013","volume":"22","author":"J Behr","year":"2013","unstructured":"Behr J (2013) Evidence-based treatment strategies in idiopathic pulmonary fibrosis. Eur Respir Rev 22:163\u2013168","journal-title":"Eur Respir Rev"},{"key":"1485_CR9","doi-asserted-by":"publisher","first-page":"476","DOI":"10.1016\/S2213-2600(20)30554-3","volume":"9","author":"J Behr","year":"2021","unstructured":"Behr J, Prasse A, Kreuter M, Johow J, Rabe KF, Bonella F, Bonnet R, Grohe C, Held M, Wilkens H, Hammerl P, Koschel D, Blaas S, Wirtz H, Ficker JH, Neumeister W, Schonfeld N, Claussen M, Kneidinger N, Frankenberger M, Hummler S, Kahn N, Tello S, Freise J, Welte T, Neuser P, Gunther A, Investigators R (2021) Pirfenidone in patients with progressive fibrotic interstitial lung diseases other than idiopathic pulmonary fibrosis (RELIEF): a double-blind, randomised, placebo-controlled, phase 2b trial. Lancet Respir Med 9:476\u2013486","journal-title":"Lancet Respir Med"},{"key":"1485_CR10","doi-asserted-by":"publisher","first-page":"3961","DOI":"10.3390\/molecules24213961","volume":"24","author":"ME Bergman","year":"2019","unstructured":"Bergman ME, Davis B, Phillips MA (2019) Medically useful plant terpenoids: biosynthesis, occurrence, and mechanism of action. Molecules 24:3961","journal-title":"Molecules"},{"key":"1485_CR11","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2021.111404","volume":"137","author":"Z Bi","year":"2021","unstructured":"Bi Z, Wang Y, Zhang W (2021) A comprehensive review of tanshinone IIA and its derivatives in fibrosis treatment. Biomed Pharmacother 137:111404","journal-title":"Biomed Pharmacother"},{"key":"1485_CR12","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1016\/j.matbio.2018.03.015","volume":"68\u201369","author":"A Burman","year":"2018","unstructured":"Burman A, Tanjore H, Blackwell TS (2018) Endoplasmic reticulum stress in pulmonary fibrosis. Matrix Biol 68\u201369:355\u2013365","journal-title":"Matrix Biol"},{"key":"1485_CR13","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1007\/s10753-016-0475-3","volume":"40","author":"PS Chauhan","year":"2017","unstructured":"Chauhan PS, Dash D, Singh R (2017) Intranasal curcumin inhibits pulmonary fibrosis by modulating matrix metalloproteinase-9 (MMP-9) in ovalbumin-induced chronic asthma. Inflammation 40:248\u2013258","journal-title":"Inflammation"},{"key":"1485_CR14","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.toxlet.2017.11.030","volume":"284","author":"H Chen","year":"2018","unstructured":"Chen H, Chen Q, Jiang CM, Shi GY, Sui BW, Zhang W, Yang LZ, Li ZY, Liu L, Su YM, Zhao WC, Sun HQ, Li ZZ, Fu Z (2018) Triptolide suppresses paraquat induced idiopathic pulmonary fibrosis by inhibiting TGFB1-dependent epithelial mesenchymal transition. Toxicol Lett 284:1\u20139","journal-title":"Toxicol Lett"},{"key":"1485_CR15","doi-asserted-by":"publisher","first-page":"178","DOI":"10.1016\/j.toxlet.2013.03.009","volume":"219","author":"P Chitra","year":"2013","unstructured":"Chitra P, Saiprasad G, Manikandan R, Sudhandiran G (2013) Berberine attenuates bleomycin induced pulmonary toxicity and fibrosis via suppressing NF-kappaB dependant TGF-beta activation: a biphasic experimental study. Toxicol Lett 219:178\u2013193","journal-title":"Toxicol Lett"},{"key":"1485_CR16","doi-asserted-by":"publisher","first-page":"1015","DOI":"10.1007\/s00109-015-1283-1","volume":"93","author":"P Chitra","year":"2015","unstructured":"Chitra P, Saiprasad G, Manikandan R, Sudhandiran G (2015) Berberine inhibits Smad and non-Smad signaling cascades and enhances autophagy against pulmonary fibrosis. J Mol Med (berl) 93:1015\u20131031","journal-title":"J Mol Med (berl)"},{"key":"1485_CR17","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1186\/s12931-015-0211-9","volume":"16","author":"IH Cho","year":"2015","unstructured":"Cho IH, Choi YJ, Gong JH, Shin D, Kang MK, Kang YH (2015) Astragalin inhibits autophagy-associated airway epithelial fibrosis. Respir Res 16:51","journal-title":"Respir Res"},{"key":"1485_CR18","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1016\/j.taap.2018.09.007","volume":"358","author":"X Cui","year":"2018","unstructured":"Cui X, Sun X, Lu F, Jiang X (2018) Baicalein represses TGF-beta1-induced fibroblast differentiation through the inhibition of miR-21. Toxicol Appl Pharmacol 358:35\u201342","journal-title":"Toxicol Appl Pharmacol"},{"key":"1485_CR19","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1111\/bcpt.12975","volume":"123","author":"T Divya","year":"2018","unstructured":"Divya T, Velavan B, Sudhandiran G (2018) Regulation of transforming growth factor-\u03b2\/smad-mediated epithelial-mesenchymal transition by celastrol provides protection against bleomycin-induced pulmonary fibrosis. Basic Clin Pharmacol Toxicol 123:122\u2013129","journal-title":"Basic Clin Pharmacol Toxicol"},{"key":"1485_CR20","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1007\/s10495-021-01684-y","volume":"26","author":"C El-Baba","year":"2021","unstructured":"El-Baba C, Baassiri A, Kiriako G, Dia B, Fadlallah S, Moodad S, Darwiche N (2021) Terpenoids\u2019 anti-cancer effects: focus on autophagy. Apoptosis 26:491\u2013511","journal-title":"Apoptosis"},{"key":"1485_CR21","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2020.109024","volume":"319","author":"F Feng","year":"2020","unstructured":"Feng F, Cheng P, Xu S, Li N, Wang H, Zhang Y, Wang W (2020) Tanshinone IIA attenuates silica-induced pulmonary fibrosis via Nrf2-mediated inhibition of EMT and TGF-beta1\/Smad signaling. Chem Biol Interact 319:109024","journal-title":"Chem Biol Interact"},{"key":"1485_CR22","doi-asserted-by":"publisher","first-page":"649","DOI":"10.1016\/j.pupt.2013.03.006","volume":"26","author":"Y Gao","year":"2013","unstructured":"Gao Y, Lu J, Zhang Y, Chen Y, Gu Z, Jiang X (2013) Baicalein attenuates bleomycin-induced pulmonary fibrosis in rats through inhibition of miR-21. Pulm Pharmacol Ther 26:649\u2013654","journal-title":"Pulm Pharmacol Ther"},{"key":"1485_CR23","doi-asserted-by":"publisher","first-page":"35696","DOI":"10.1038\/srep35696","volume":"6","author":"R Guan","year":"2016","unstructured":"Guan R, Wang X, Zhao X, Song N, Zhu J, Wang J, Wang J, Xia C, Chen Y, Zhu D, Shen L (2016) Emodin ameliorates bleomycin-induced pulmonary fibrosis in rats by suppressing epithelial-mesenchymal transition and fibroblast activation. Sci Rep 6:35696","journal-title":"Sci Rep"},{"key":"1485_CR24","first-page":"1","volume":"2017","author":"S Guan","year":"2017","unstructured":"Guan S, Liu Q, Han F, Gu W, Song L, Zhang Y, Guo X, Xu W (2017) Ginsenoside Rg1 ameliorates cigarette smoke-induced airway fibrosis by suppressing the TGF-\u03b21\/smad pathway in vivo and in vitro. Biomed Res Int 2017:1\u201312","journal-title":"Biomed Res Int"},{"key":"1485_CR25","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1016\/j.bbrc.2020.04.023","volume":"527","author":"K Guo","year":"2020","unstructured":"Guo K, Chen J, Chen Z, Luo G, Yang S, Zhang M, Hong J, Zhang L, Chen C (2020) Triptolide alleviates radiation-induced pulmonary fibrosis via inhibiting IKKbeta stimulated LOX production. Biochem Biophys Res Commun 527:283\u2013288","journal-title":"Biochem Biophys Res Commun"},{"key":"1485_CR26","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1016\/j.matbio.2017.12.004","volume":"73","author":"AJ Haak","year":"2018","unstructured":"Haak AJ, Tan Q, Tschumperlin DJ (2018) Matrix biomechanics and dynamics in pulmonary fibrosis. Matrix Biol 73:64\u201376","journal-title":"Matrix Biol"},{"key":"1485_CR27","doi-asserted-by":"publisher","first-page":"1481","DOI":"10.3390\/molecules27051481","volume":"27","author":"M Hasan","year":"2022","unstructured":"Hasan M, Paul NC, Paul SK, Saikat ASM, Akter H, Mandal M, Lee S-S (2022) Natural product-based potential therapeutic interventions of pulmonary fibrosis. Molecules 27:1481","journal-title":"Molecules"},{"key":"1485_CR28","doi-asserted-by":"publisher","first-page":"4190","DOI":"10.3892\/mmr.2015.3333","volume":"11","author":"H He","year":"2015","unstructured":"He H, Tang H, Gao L, Wu Y, Feng Z, Lin H, Wu T (2015) Tanshinone IIA attenuates bleomycin-induced pulmonary fibrosis in rats. Mol Med Rep 11:4190\u20134196","journal-title":"Mol Med Rep"},{"key":"1485_CR29","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1016\/j.matbio.2018.03.021","volume":"71\u201372","author":"JC Hewlett","year":"2018","unstructured":"Hewlett JC, Kropski JA, Blackwell TS (2018) Idiopathic pulmonary fibrosis: epithelial-mesenchymal interactions and emerging therapeutic targets. Matrix Biol 71\u201372:112\u2013127","journal-title":"Matrix Biol"},{"key":"1485_CR30","doi-asserted-by":"publisher","first-page":"1454","DOI":"10.1016\/j.biopha.2018.08.111","volume":"107","author":"S Hosseini","year":"2018","unstructured":"Hosseini S, Imenshahidi M, Hosseinzadeh H, Karimi G (2018) Effects of plant extracts and bioactive compounds on attenuation of bleomycin-induced pulmonary fibrosis. Biomed Pharmacother 107:1454\u20131465","journal-title":"Biomed Pharmacother"},{"key":"1485_CR31","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1186\/s12890-016-0294-1","volume":"16","author":"X Huang","year":"2016","unstructured":"Huang X, He Y, Chen Y, Wu P, Gui D, Cai H, Chen A, Chen M, Dai C, Yao D, Wang L (2016) Baicalin attenuates bleomycin-induced pulmonary fibrosis via adenosine A2a receptor related TGF-beta1-induced ERK1\/2 signaling pathway. BMC Pulm Med 16:132","journal-title":"BMC Pulm Med"},{"key":"1485_CR32","first-page":"2213","volume":"44","author":"XT Huang","year":"2019","unstructured":"Huang XT, Liu W, Zhou Y, Hao CX, Zhou Y, Zhang CY, Sun CC, Luo ZQ, Tang SY (2019) Dihydroartemisinin attenuates lipopolysaccharide-induced acute lung injury in mice by suppressing NF-\u03baB signaling in an Nrf2-dependent manner. Int J Mol Med 44:2213\u20132222","journal-title":"Int J Mol Med"},{"key":"1485_CR33","doi-asserted-by":"publisher","first-page":"853","DOI":"10.1017\/S0007114515002597","volume":"114","author":"D Impellizzeri","year":"2015","unstructured":"Impellizzeri D, Talero E, Siracusa R, Alcaide A, Cordaro M, Maria ZJ, Bruschetta G, Crupi R, Esposito E, Cuzzocrea S, Motilva V (2015) Protective effect of polyphenols in an inflammatory process associated with experimental pulmonary fibrosis in mice. Br J Nutr 114:853\u2013865","journal-title":"Br J Nutr"},{"key":"1485_CR34","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1016\/j.biopha.2016.04.027","volume":"81","author":"SA Javad-Mousavi","year":"2016","unstructured":"Javad-Mousavi SA, Hemmati AA, Mehrzadi S, Hosseinzadeh A, Houshmand G, Rashidi NMR, Mehrabani M, Goudarzi M (2016) Protective effect of Berberis vulgaris fruit extract against Paraquat-induced pulmonary fibrosis in rats. Biomed Pharmacother 81:329\u2013336","journal-title":"Biomed Pharmacother"},{"key":"1485_CR35","doi-asserted-by":"publisher","first-page":"794","DOI":"10.1038\/aps.2016.36","volume":"37","author":"Y Ji","year":"2016","unstructured":"Ji Y, Dou Y-N, Zhao Q-W, Zhang J-Z, Yang Y, Wang T, Xia Y-F, Dai Y, Wei Z-F (2016) Paeoniflorin suppresses TGF-\u03b2 mediated epithelial-mesenchymal transition in pulmonary fibrosis through a Smad-dependent pathway. Acta Pharmacol Sin 37:794\u2013804","journal-title":"Acta Pharmacol Sin"},{"key":"1485_CR36","doi-asserted-by":"publisher","first-page":"836","DOI":"10.1007\/s11655-012-1151-6","volume":"19","author":"M Jin","year":"2013","unstructured":"Jin M, Sun C-Y, Pei C-Q, Wang L, Zhang P-C (2013) Effect of safflor yellow injection on inhibiting lipopolysaccharide-induced pulmonary inflammatory injury in mice. Chin J Integr Med 19:836\u2013843","journal-title":"Chin J Integr Med"},{"key":"1485_CR37","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a022293","volume":"10","author":"KK Kim","year":"2018","unstructured":"Kim KK, Sheppard D, Chapman HA (2018) TGF-\u03b21 signaling and tissue fibrosis. Cold Spring Harb Perspect Biol 10:a022293","journal-title":"Cold Spring Harb Perspect Biol"},{"key":"1485_CR38","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1164\/rccm.200501-017PP","volume":"172","author":"VL Kinnula","year":"2005","unstructured":"Kinnula VL, Fattman CL, Tan RJ, Oury TD (2005) Oxidative stress in pulmonary fibrosis: a possible role for redox modulatory therapy. Am J Respir Crit Care Med 172:417\u2013422","journal-title":"Am J Respir Crit Care Med"},{"key":"1485_CR39","doi-asserted-by":"publisher","first-page":"1248","DOI":"10.1002\/jcp.22448","volume":"226","author":"I Kolosova","year":"2011","unstructured":"Kolosova I, Nethery D, Kern JA (2011) Role of Smad2\/3 and p38 MAP kinase in TGF-\u03b21-induced epithelial-mesenchymal transition of pulmonary epithelial cells. J Cell Physiol 226:1248\u20131254","journal-title":"J Cell Physiol"},{"key":"1485_CR40","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2019.104541","volume":"151","author":"X Lan","year":"2020","unstructured":"Lan X, Zhao J, Zhang Y, Chen Y, Liu Y, Xu F (2020) Oxymatrine exerts organ- and tissue-protective effects by regulating inflammation, oxidative stress, apoptosis, and fibrosis: from bench to bedside. Pharmacol Res 151:104541","journal-title":"Pharmacol Res"},{"key":"1485_CR41","doi-asserted-by":"publisher","first-page":"590","DOI":"10.1667\/RR1522.1","volume":"173","author":"JC Lee","year":"2010","unstructured":"Lee JC, Kinniry PA, Arguiri E, Serota M, Kanterakis S, Chatterjee S, Solomides CC, Javvadi P, Koumenis C, Cengel KA, Christofidou-Solomidou M (2010) Dietary curcumin increases antioxidant defenses in lung, ameliorates radiation-induced pulmonary fibrosis, and improves survival in mice. Radiat Res 173:590\u2013601","journal-title":"Radiat Res"},{"key":"1485_CR42","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1111\/fcp.12232","volume":"31","author":"L Li","year":"2017","unstructured":"Li L, Hou X, Xu R, Liu C, Tu M (2017) Research review on the pharmacological effects of astragaloside IV. Fundam Clin Pharmacol 31:17\u201336","journal-title":"Fundam Clin Pharmacol"},{"key":"1485_CR43","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1186\/s12931-018-0806-z","volume":"19","author":"XH Li","year":"2018","unstructured":"Li XH, Xiao T, Yang JH, Qin Y, Gao JJ, Liu HJ, Zhou HG (2018) Parthenolide attenuated bleomycin-induced pulmonary fibrosis via the NF-kappaB\/Snail signaling pathway. Respir Res 19:111","journal-title":"Respir Res"},{"key":"1485_CR44","doi-asserted-by":"publisher","first-page":"10501","DOI":"10.1111\/jcmm.15665","volume":"24","author":"J Li","year":"2020","unstructured":"Li J, Liu J, Yue W, Xu K, Cai W, Cui F, Li Z, Wang W, He J (2020a) Andrographolide attenuates epithelial-mesenchymal transition induced by TGF-\u03b21 in alveolar epithelial cells. J Cell Mol Med 24:10501\u201310511","journal-title":"J Cell Mol Med"},{"key":"1485_CR45","doi-asserted-by":"publisher","first-page":"386","DOI":"10.1016\/j.jgr.2019.12.003","volume":"44","author":"X Li","year":"2020","unstructured":"Li X, Mo N, Li Z (2020b) Ginsenosides: potential therapeutic source for fibrosis-associated human diseases. J Ginseng Res 44:386\u2013398","journal-title":"J Ginseng Res"},{"key":"1485_CR46","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12906-016-0991-6","volume":"16","author":"M-W Liu","year":"2015","unstructured":"Liu M-W, Liu R, Wu H-Y, Li Y-Y, Su M-X, Dong M-N, Zhang W, Qian C-Y (2015) Radix puerariae extracts ameliorate paraquat-induced pulmonary fibrosis by attenuating follistatin-like 1 and nuclear factor erythroid 2p45-related factor-2 signalling pathways through downregulation of miRNA-21 expression. BMC Complement Altern Med 16:1\u20135","journal-title":"BMC Complement Altern Med"},{"key":"1485_CR47","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1016\/j.taap.2016.08.004","volume":"309","author":"B Liu","year":"2016","unstructured":"Liu B, Cao B, Zhang D, Xiao N, Chen H, Li GQ, Peng SC, Wei LQ (2016a) Salvianolic acid B protects against paraquat-induced pulmonary injury by mediating Nrf2\/Nox4 redox balance and TGF-beta1\/Smad3 signaling. Toxicol Appl Pharmacol 309:111\u2013120","journal-title":"Toxicol Appl Pharmacol"},{"key":"1485_CR48","doi-asserted-by":"publisher","first-page":"27610","DOI":"10.1038\/srep27610","volume":"6","author":"Q Liu","year":"2016","unstructured":"Liu Q, Chu H, Ma Y, Wu T, Qian F, Ren X, Tu W, Zhou X, Jin L, Wu W, Wang J (2016b) Salvianolic acid B attenuates experimental pulmonary fibrosis through inhibition of the TGF-\u03b2 signaling pathway. Sci Rep 6:27610","journal-title":"Sci Rep"},{"key":"1485_CR49","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/j.ejphar.2018.09.030","volume":"840","author":"Q Liu","year":"2018","unstructured":"Liu Q, Shi X, Tang L, Xu W, Jiang S, Ding W, Feng Q, Chu H, Ma Y, Li Y, Lu J, Pu W, Zhou X, Jin L, Wang J, Wu W (2018) Salvianolic acid B attenuates experimental pulmonary inflammation by protecting endothelial cells against oxidative stress injury. Eur J Pharmacol 840:9\u201319","journal-title":"Eur J Pharmacol"},{"key":"1485_CR50","doi-asserted-by":"publisher","first-page":"1418","DOI":"10.1089\/dna.2019.4941","volume":"38","author":"H Liu","year":"2019","unstructured":"Liu H, Yu H, Cao Z, Gu J, Pei L, Jia M, Su M (2019a) Kaempferol modulates autophagy and alleviates silica-induced pulmonary fibrosis. DNA Cell Biol 38:1418\u20131426","journal-title":"DNA Cell Biol"},{"key":"1485_CR51","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1186\/s12890-019-0799-5","volume":"19","author":"MW Liu","year":"2019","unstructured":"Liu MW, Su MX, Tang DY, Hao L, Xun XH, Huang YQ (2019b) Ligustrazin increases lung cell autophagy and ameliorates paraquat-induced pulmonary fibrosis by inhibiting PI3K\/Akt\/mTOR and hedgehog signalling via increasing miR-193a expression. BMC Pulm Med 19:35","journal-title":"BMC Pulm Med"},{"key":"1485_CR52","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1111\/jgh.14299","volume":"34","author":"T Liu","year":"2019","unstructured":"Liu T, Xu L, Wang C, Chen K, Xia Y, Li J, Li S, Wu L, Feng J, Xu S, Wang W, Lu X, Fan X, Mo W, Zhou Y, Zhao Y, Guo C (2019c) Alleviation of hepatic fibrosis and autophagy via inhibition of transforming growth factor-\u03b2 1\/Smads pathway through shikonin. J Gastroenterol Hepatol 34:263\u2013276","journal-title":"J Gastroenterol Hepatol"},{"key":"1485_CR53","first-page":"447","volume":"17","author":"P Lu","year":"2022","unstructured":"Lu P, Li J, Liu C, Yang J, Peng H, Xue Z, Liu Z (2022) Salvianolic acid B dry powder inhaler for the treatment of idiopathic pulmonary fibrosis. Asian J Pharm Sci 17:447\u2013461","journal-title":"Asian J Pharm Sci"},{"key":"1485_CR54","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1186\/s12931-021-01711-1","volume":"22","author":"F Luppi","year":"2021","unstructured":"Luppi F, Kalluri M, Faverio P, Kreuter M, Ferrara G (2021) Idiopathic pulmonary fibrosis beyond the lung: understanding disease mechanisms to improve diagnosis and management. Respir Res 22:109","journal-title":"Respir Res"},{"key":"1485_CR55","first-page":"442","volume":"10","author":"X Ma","year":"2013","unstructured":"Ma X, Chen R, Liu X, Xie J, Si K, Duan L (2013) Effects of matrine on JAK-STAT signaling transduction pathways in bleomycin-induced pulmonary fibrosis. Afr J Tradit Complement Altern Med 10:442\u2013448","journal-title":"Afr J Tradit Complement Altern Med"},{"key":"1485_CR56","doi-asserted-by":"publisher","first-page":"3317","DOI":"10.3390\/cells11203317","volume":"11","author":"MW Millar","year":"2022","unstructured":"Millar MW, Fazal F, Rahman A (2022) Therapeutic targeting of NF-\u03baB in acute lung injury: a double-edged sword. Cells 11:3317","journal-title":"Cells"},{"key":"1485_CR57","doi-asserted-by":"publisher","first-page":"515","DOI":"10.1146\/annurev-pathol-042320-030240","volume":"17","author":"BJ Moss","year":"2022","unstructured":"Moss BJ, Ryter SW, Rosas IO (2022) Pathogenic mechanisms underlying idiopathic pulmonary fibrosis. Annu Rev Pathol 17:515\u2013546","journal-title":"Annu Rev Pathol"},{"key":"1485_CR58","doi-asserted-by":"publisher","first-page":"L14","DOI":"10.1152\/ajplung.00400.2018","volume":"317","author":"J-P Ng-Blichfeldt","year":"2019","unstructured":"Ng-Blichfeldt J-P, de Jong T, Kortekaas RK, Wu X, Lindner M, Guryev V, Hiemstra PS, Stolk J, K\u00f6nigshoff M, Gosens R (2019) TGF-\u03b2 activation impairs fibroblast ability to support adult lung epithelial progenitor cell organoid formation. Am J Physiol-Lung Cell Mol Physiol 317:L14\u2013L28","journal-title":"Am J Physiol-Lung Cell Mol Physiol"},{"key":"1485_CR59","doi-asserted-by":"publisher","first-page":"1119","DOI":"10.1016\/j.biopha.2017.09.023","volume":"95","author":"Y Nie","year":"2017","unstructured":"Nie Y, Yang Y, Zhang J, Cai G, Chang Y, Chai G, Guo C (2017) Shikonin suppresses pulmonary fibroblasts proliferation and activation by regulating Akt and p38 MAPK signaling pathways. Biomed Pharmacother 95:1119\u20131128","journal-title":"Biomed Pharmacother"},{"key":"1485_CR60","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2019.105696","volume":"74","author":"Y Nie","year":"2019","unstructured":"Nie Y, Zhang D, Qian F, Wu Y (2019) Baccatin III ameliorates bleomycin-induced pulmonary fibrosis via suppression of TGF-beta1 production and TGF-beta1-induced fibroblast differentiation. Int Immunopharmacol 74:105696","journal-title":"Int Immunopharmacol"},{"key":"1485_CR61","doi-asserted-by":"publisher","first-page":"1061","DOI":"10.1016\/j.pharep.2015.03.012","volume":"67","author":"J Nikbakht","year":"2015","unstructured":"Nikbakht J, Hemmati AA, Arzi A, Mansouri MT, Rezaie A, Ghafourian M (2015) Protective effect of gallic acid against bleomycin-induced pulmonary fibrosis in rats. Pharmacol Rep 67:1061\u20131067","journal-title":"Pharmacol Rep"},{"key":"1485_CR62","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1002\/j.2040-4603.2020.tb00120.x","volume":"10","author":"E Otoupalova","year":"2020","unstructured":"Otoupalova E, Smith S, Cheng G, Thannickal VJ (2020) Oxidative stress in pulmonary fibrosis. Compr Physiol 10:509\u2013547","journal-title":"Compr Physiol"},{"key":"1485_CR63","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2020.107277","volume":"91","author":"X Pang","year":"2021","unstructured":"Pang X, Shao L, Nie X, Yan H, Li C, Yeo AJ, Lavin MF, Xia Q, Shao H, Yu G, Jia Q, Peng C (2021) Emodin attenuates silica-induced lung injury by inhibition of inflammation, apoptosis and epithelial-mesenchymal transition. Int Immunopharmacol 91:107277","journal-title":"Int Immunopharmacol"},{"key":"1485_CR64","doi-asserted-by":"publisher","first-page":"2269","DOI":"10.3390\/ijms21072269","volume":"21","author":"T Parimon","year":"2020","unstructured":"Parimon T, Yao C, Stripp BR, Noble PW, Chen P (2020) Alveolar epithelial type II Cells as drivers of lung fibrosis in idiopathic pulmonary fibrosis. Int J Mol Sci 21:2269","journal-title":"Int J Mol Sci"},{"key":"1485_CR65","doi-asserted-by":"publisher","first-page":"548","DOI":"10.1101\/gad.237081.113","volume":"28","author":"V Pekovic-Vaughan","year":"2014","unstructured":"Pekovic-Vaughan V, Gibbs J, Yoshitane H, Yang N, Pathiranage D, Guo B, Sagami A, Taguchi K, Bechtold D, Loudon A, Yamamoto M, Chan J, van der Horst GTJ, Fukada Y, Meng Q-J (2014) The circadian clock regulates rhythmic activation of the NRF2\/glutathione-mediated antioxidant defense pathway to modulate pulmonary fibrosis. Genes Dev 28:548\u2013560","journal-title":"Genes Dev"},{"key":"1485_CR66","doi-asserted-by":"publisher","first-page":"978","DOI":"10.1038\/s41419-020-03178-2","volume":"11","author":"L Peng","year":"2020","unstructured":"Peng L, Wen L, Shi Q-F, Gao F, Huang B, Meng J, Hu C-P, Wang C-M (2020) Scutellarin ameliorates pulmonary fibrosis through inhibiting NF-\u03baB\/NLRP3-mediated epithelial\u2013mesenchymal transition and inflammation. Cell Death Dis 11:978","journal-title":"Cell Death Dis"},{"key":"1485_CR67","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1186\/s12943-022-01569-x","volume":"21","author":"D Peng","year":"2022","unstructured":"Peng D, Fu M, Wang M, Wei Y, Wei X (2022) Targeting TGF-\u03b2 signal transduction for fibrosis and cancer therapy. Mol Cancer 21:104","journal-title":"Mol Cancer"},{"key":"1485_CR68","doi-asserted-by":"publisher","first-page":"2031","DOI":"10.1007\/s00018-020-03693-7","volume":"78","author":"THG Phan","year":"2021","unstructured":"Phan THG, Paliogiannis P, Nasrallah GK, Giordo R, Eid AH, Fois AG, Zinellu A, Mangoni AA, Pintus G (2021) Emerging cellular and molecular determinants of idiopathic pulmonary fibrosis. Cell Mol Life Sci 78:2031\u20132057","journal-title":"Cell Mol Life Sci"},{"key":"1485_CR69","doi-asserted-by":"publisher","first-page":"4390","DOI":"10.3390\/molecules25194390","volume":"25","author":"XM Piao","year":"2020","unstructured":"Piao XM, Huo Y, Kang JP, Mathiyalagan R, Zhang H, Yang DU, Kim M, Yang DC, Kang SC, Wang YP (2020) Diversity of ginsenoside profiles produced by various processing technologies. Molecules 25:4390","journal-title":"Molecules"},{"key":"1485_CR70","doi-asserted-by":"publisher","first-page":"4354","DOI":"10.1111\/jcmm.13725","volume":"22","author":"W Qian","year":"2018","unstructured":"Qian W, Cai X, Qian Q, Zhang W, Wang D (2018) Astragaloside<scp>IV<\/scp>modulates<scp>TGF<\/scp>-\u03b21-dependent epithelial-mesenchymal transition in bleomycin-induced pulmonary fibrosis. J Cell Mol Med 22:4354\u20134365","journal-title":"J Cell Mol Med"},{"key":"1485_CR71","doi-asserted-by":"publisher","first-page":"1010","DOI":"10.3390\/jof8101010","volume":"8","author":"VQ Resende","year":"2022","unstructured":"Resende VQ, Reis-Goes KH, Finato AC, de F\u00e1tima Almeida-Donanzam D, dos Santos AR, Perico J, Amorim BC, Venturini J (2022) Combined silymarin and cotrimoxazole therapy attenuates pulmonary fibrosis in experimental paracoccidioidomycosis. J Fungi 8:1010","journal-title":"J Fungi"},{"key":"1485_CR72","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s10020-019-0096-z","volume":"25","author":"LR Rodriguez","year":"2019","unstructured":"Rodriguez LR, Bui SN, Beuschel RT, Ellis E, Liberti EM, Chhina MK, Cannon B, Lemma M, Nathan SD, Grant GM (2019) Curcumin induced oxidative stress attenuation by N-acetylcysteine co-treatment: a fibroblast and epithelial cell in-vitro study in idiopathic pulmonary fibrosis. Mol Med 25:1\u201312","journal-title":"Mol Med"},{"key":"1485_CR73","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1016\/j.pupt.2016.07.009","volume":"40","author":"P Rogliani","year":"2016","unstructured":"Rogliani P, Calzetta L, Cavalli F, Matera MG, Cazzola M (2016) Pirfenidone, nintedanib and N-acetylcysteine for the treatment of idiopathic pulmonary fibrosis: a systematic review and meta-analysis. Pulm Pharmacol Ther 40:95\u2013103","journal-title":"Pulm Pharmacol Ther"},{"key":"1485_CR74","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1016\/j.cell.2016.06.028","volume":"166","author":"H Ruby","year":"2016","unstructured":"Ruby H, Rebecca J, Jean T (2016) EMT: 2016. Cell 166:21\u201345","journal-title":"Cell"},{"key":"1485_CR75","doi-asserted-by":"publisher","first-page":"1571","DOI":"10.1164\/rccm.201612-2480OC","volume":"196","author":"C Ryu","year":"2017","unstructured":"Ryu C, Sun H, Gulati M, Herazo-Maya JD, Chen Y, Osafo-Addo A, Brandsdorfer C, Winkler J, Blaul C, Faunce J, Pan H, Woolard T, Tzouvelekis A, Antin-Ozerkis DE, Puchalski JT, Slade M, Gonzalez AL, Bogenhagen DF, Kirillov V, Feghali-Bostwick C, Gibson K, Lindell K, Herzog RI, Dela Cruz CS, Mehal W, Kaminski N, Herzog EL, Trujillo G (2017) Extracellular mitochondrial DNA is generated by fibroblasts and predicts death in idiopathic pulmonary fibrosis. Am J Respirat Crit Care Med 196:1571\u20131581","journal-title":"Am J Respirat Crit Care Med"},{"key":"1485_CR76","doi-asserted-by":"publisher","first-page":"14959","DOI":"10.3390\/ijms232314959","volume":"23","author":"IA Savin","year":"2022","unstructured":"Savin IA, Zenkova MA, Sen\u2019kova AV (2022) Pulmonary fibrosis as a result of acute lung inflammation: molecular mechanisms, relevant in vivo models, prognostic and therapeutic approaches. Int J Mol Sci 23:14959","journal-title":"Int J Mol Sci"},{"key":"1485_CR77","doi-asserted-by":"publisher","first-page":"7044","DOI":"10.1021\/acs.jmedchem.2c00223","volume":"65","author":"KA Scott","year":"2022","unstructured":"Scott KA, Cox PB, Njardarson JT (2022) Phenols in pharmaceuticals: analysis of a recurring motif. J Med Chem 65:7044\u20137072","journal-title":"J Med Chem"},{"key":"1485_CR78","doi-asserted-by":"publisher","first-page":"106676","DOI":"10.1016\/j.intimp.2020.106676","volume":"85","author":"SB Shaikh","year":"2020","unstructured":"Shaikh SB, Prabhakar Bhandary Y (2020) Effect of curcumin on IL-17A mediated pulmonary AMPK kinase\/cyclooxygenase-2 expressions via activation of NF\u03baB in bleomycin-induced acute lung injury in vivo. Int Immunopharmacol 85:106676","journal-title":"Int Immunopharmacol"},{"key":"1485_CR79","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2021.112442","volume":"146","author":"H Slika","year":"2022","unstructured":"Slika H, Mansour H, Wehbe N, Nasser SA, Iratni R, Nasrallah G, Shaito A, Ghaddar T, Kobeissy F, Eid AH (2022) Therapeutic potential of flavonoids in cancer: ROS-mediated mechanisms. Biomed Pharmacother 146:112442","journal-title":"Biomed Pharmacother"},{"key":"1485_CR80","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1016\/j.pupt.2008.12.010","volume":"22","author":"N Sriram","year":"2009","unstructured":"Sriram N, Kalayarasan S, Sudhandiran G (2009) Epigallocatechin-3-gallate augments antioxidant activities and inhibits inflammation during bleomycin-induced experimental pulmonary fibrosis through Nrf2-Keap1 signaling. Pulm Pharmacol Ther 22:221\u2013236","journal-title":"Pulm Pharmacol Ther"},{"key":"1485_CR81","doi-asserted-by":"publisher","first-page":"1096","DOI":"10.1111\/resp.13415","volume":"23","author":"AG Stewart","year":"2018","unstructured":"Stewart AG, Thomas B, Koff J (2018) TGF-beta: master regulator of inflammation and fibrosis. Respirology 23:1096\u20131097","journal-title":"Respirology"},{"key":"1485_CR82","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2022.106419","volume":"184","author":"Q Sun","year":"2022","unstructured":"Sun Q, Liu Q, Zhou X, Wang X, Li H, Zhang W, Yuan H, Sun C (2022) Flavonoids regulate tumor-associated macrophages\u2014from structure-activity relationship to clinical potential (Review). Pharmacol Res 184:106419","journal-title":"Pharmacol Res"},{"key":"1485_CR83","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2016\/7601393","volume":"2016","author":"NH Turgut","year":"2016","unstructured":"Turgut NH, Kara H, Elagoz S, Deveci K, Gungor H, Arslanbas E (2016) The protective effect of naringin against bleomycin-induced pulmonary fibrosis in wistar rats. Pulm Med 2016:1\u201312","journal-title":"Pulm Med"},{"key":"1485_CR84","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1016\/j.taap.2017.10.001","volume":"336","author":"C Veith","year":"2017","unstructured":"Veith C, Drent M, Bast A, van Schooten FJ, Boots AW (2017) The disturbed redox-balance in pulmonary fibrosis is modulated by the plant flavonoid quercetin. Toxicol Appl Pharmacol 336:40\u201348","journal-title":"Toxicol Appl Pharmacol"},{"key":"1485_CR85","doi-asserted-by":"publisher","first-page":"511","DOI":"10.1248\/bpb.34.511","volume":"34","author":"L Wang","year":"2011","unstructured":"Wang L, Jin M, Zang B-X, Wu Y (2011) Inhibitory effect of safflor yellow on pulmonary fibrosis. Biol Pharm Bull 34:511\u2013516","journal-title":"Biol Pharm Bull"},{"key":"1485_CR86","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0070725","volume":"8","author":"C Wang","year":"2013","unstructured":"Wang C, Song X, Li Y, Han F, Gao S, Wang X, Xie S, Lv C (2013) Low-dose paclitaxel ameliorates pulmonary fibrosis by suppressing TGF-\u03b21\/Smad3 pathway via miR-140 upregulation. PLoS ONE 8:e70725","journal-title":"PLoS ONE"},{"key":"1485_CR87","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1016\/j.biopha.2018.05.104","volume":"105","author":"J Wang","year":"2018","unstructured":"Wang J, He F, Chen L, Li Q, Jin S, Zheng H, Lin J, Zhang H, Ma S, Mei J, Yu J (2018a) Resveratrol inhibits pulmonary fibrosis by regulating miR-21 through MAPK\/AP-1 pathways. Biomed Pharmacother 105:37\u201344","journal-title":"Biomed Pharmacother"},{"key":"1485_CR88","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1080\/13880209.2018.1492620","volume":"56","author":"Z-L Wang","year":"2018","unstructured":"Wang Z-L, Wang S, Kuang Y, Hu Z-M, Qiao X, Ye M (2018b) A comprehensive review on phytochemistry, pharmacology, and flavonoid biosynthesis of Scutellaria baicalensis. Pharm Biol 56:465\u2013484","journal-title":"Pharm Biol"},{"key":"1485_CR89","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2021.734450","volume":"12","author":"J Wang","year":"2021","unstructured":"Wang J, Wu Q, Ding L, Song S, Li Y, Shi L, Wang T, Zhao D, Wang Z, Li X (2021a) Therapeutic effects and molecular mechanisms of bioactive compounds against respiratory diseases: traditional chinese medicine theory and high-frequency use. Front Pharmacol 12:734450","journal-title":"Front Pharmacol"},{"key":"1485_CR90","doi-asserted-by":"publisher","first-page":"4605","DOI":"10.18632\/aging.202420","volume":"13","author":"Z Wang","year":"2021","unstructured":"Wang Z, Li X, Chen H, Han L, Ji X, Wang Q, Wei L, Miu Y, Wang J, Mao J, Zhang Z (2021b) Resveratrol alleviates bleomycin-induced pulmonary fibrosis via suppressing HIF-1\u03b1 and NF-\u03baB expression. Aging 13:4605\u20134616","journal-title":"Aging"},{"key":"1485_CR91","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1016\/j.apsb.2021.07.023","volume":"12","author":"J Wang","year":"2022","unstructured":"Wang J, Hu K, Cai X, Yang B, He Q, Wang J, Weng Q (2022a) Targeting PI3K\/AKT signaling for treatment of idiopathic pulmonary fibrosis. Acta Pharm Sin B 12:18\u201332","journal-title":"Acta Pharm Sin B"},{"key":"1485_CR92","doi-asserted-by":"publisher","first-page":"1063","DOI":"10.1142\/S0192415X22500434","volume":"50","author":"L Wang","year":"2022","unstructured":"Wang L, Zhu T, Feng D, Li R, Zhang C (2022b) Polyphenols from chinese herbal medicine: molecular mechanisms and therapeutic targets in pulmonary fibrosis. Am J Chin Med 50:1063\u20131094","journal-title":"Am J Chin Med"},{"key":"1485_CR93","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1002\/biof.1432","volume":"44","author":"X Wei","year":"2018","unstructured":"Wei X, Chen Y, Huang W (2018) Ginsenoside Rg1 ameliorates liver fibrosis via suppressing epithelial to mesenchymal transition and reactive oxygen species production in vitro and in vivo. BioFactors 44:327\u2013335","journal-title":"BioFactors"},{"key":"1485_CR94","doi-asserted-by":"publisher","first-page":"1155","DOI":"10.1007\/s00210-023-02390-z","volume":"396","author":"Y Wei","year":"2023","unstructured":"Wei Y, Sun L, Liu C, Li L (2023) Naringin regulates endoplasmic reticulum stress and mitophagy through the ATF3\/PINK1 signaling axis to alleviate pulmonary fibrosis. Naunyn-Schmiedeberg\u2019s Arch Pharmacol 396:1155\u20131169","journal-title":"Naunyn-Schmiedeberg\u2019s Arch Pharmacol"},{"key":"1485_CR95","doi-asserted-by":"publisher","first-page":"1434","DOI":"10.1183\/09031936.00174914","volume":"45","author":"L Wollin","year":"2015","unstructured":"Wollin L, Wex E, Pautsch A, Schnapp G, Hostettler KE, Stowasser S, Kolb M (2015) Mode of action of nintedanib in the treatment of idiopathic pulmonary fibrosis. Eur Respir J 45:1434\u20131445","journal-title":"Eur Respir J"},{"key":"1485_CR96","doi-asserted-by":"publisher","first-page":"578","DOI":"10.7150\/ijms.8365","volume":"11","author":"H Wu","year":"2014","unstructured":"Wu H, Li Y, Wang Y, Xu D, Li C, Liu M, Sun X, Li Z (2014) Tanshinone IIA attenuates bleomycin-induced pulmonary fibrosis via modulating angiotensin-converting enzyme 2\/ angiotensin-(1\u20137) axis in rats. Int J Med Sci 11:578\u2013586","journal-title":"Int J Med Sci"},{"key":"1485_CR97","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2020.117552","volume":"250","author":"Y Xiao","year":"2020","unstructured":"Xiao Y, Zhou L, Zhang T, Qin C, Wei P, Luo L, Luo L, Huang G, Chen A, Liu G (2020) Anti-fibrosis activity of quercetin attenuates rabbit tracheal stenosis via the TGF-beta\/AKT\/mTOR signaling pathway. Life Sci 250:117552","journal-title":"Life Sci"},{"key":"1485_CR98","doi-asserted-by":"publisher","first-page":"5883","DOI":"10.1002\/ptr.7253","volume":"35","author":"Z Xue","year":"2021","unstructured":"Xue Z, Zhao F, Sang X, Qiao Y, Shao R, Wang Y, Gao S, Fan G, Zhu Y, Yang J (2021) Combination therapy of tanshinone <scp>IIA<\/scp> and puerarin for pulmonary fibrosis via targeting <scp>IL6-JAK2-STAT3<\/scp> \/ <scp>STAT1<\/scp> signaling pathways. Phytother Res 35:5883\u20135898","journal-title":"Phytother Res"},{"key":"1485_CR99","doi-asserted-by":"publisher","first-page":"4643","DOI":"10.3892\/mmr.2016.5838","volume":"14","author":"T Yang","year":"2016","unstructured":"Yang T, Wang J, Pang Y, Dang X, Ren H, Liu Y, Chen M, Shang D (2016) Emodin suppresses silica-induced lung fibrosis by promoting Sirt1 signaling via direct contact. Mol Med Rep 14:4643\u20134649","journal-title":"Mol Med Rep"},{"key":"1485_CR100","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1016\/j.lfs.2018.05.022","volume":"205","author":"DX Yang","year":"2018","unstructured":"Yang DX, Qiu J, Zhou HH, Yu Y, Zhou DL, Xu Y, Zhu MZ, Ge XP, Li JM, Lv CJ, Zhang HQ, Yuan WD (2018) Dihydroartemisinin alleviates oxidative stress in bleomycin-induced pulmonary fibrosis. Life Sci 205:176\u2013183","journal-title":"Life Sci"},{"key":"1485_CR101","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3892\/mmr.2020.11726","volume":"23","author":"J Yao","year":"2020","unstructured":"Yao J, Fang X, Zhang C, Yang Y, Wang D, Chen Q, Zhong G (2020) Astragaloside IV attenuates hypoxia-induced pulmonary vascular remodeling via the Notch signaling pathway. Mol Med Rep 23:1","journal-title":"Mol Med Rep"},{"key":"1485_CR102","doi-asserted-by":"publisher","first-page":"92","DOI":"10.3892\/ijmm.2014.1745","volume":"34","author":"H You","year":"2014","unstructured":"You H, Wei L, Sun W-L, Wang L, Yang Z-L, Liu Y, Zheng K, Wang Y, Zhang W-J (2014) The green tea extract epigallocatechin-3-gallate inhibits irradiation-induced pulmonary fibrosis in adult rats. Int J Mol Med 34:92\u2013102","journal-title":"Int J Mol Med"},{"key":"1485_CR103","doi-asserted-by":"publisher","first-page":"1110","DOI":"10.18632\/aging.203874","volume":"14","author":"X You","year":"2022","unstructured":"You X, Jiang X, Zhang C, Jiang K, Zhao X, Guo T, Zhu X, Bao J, Dou H (2022) Dihydroartemisinin attenuates pulmonary inflammation and fibrosis in rats by suppressing JAK2\/STAT3 signaling. Aging 14:1110\u20131127","journal-title":"Aging"},{"key":"1485_CR104","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1038\/s41392-020-00312-6","volume":"5","author":"H Yu","year":"2020","unstructured":"Yu H, Lin L, Zhang Z, Zhang H, Hu H (2020) Targeting NF-\u03baB pathway for the therapy of diseases: mechanism and clinical study. Signal Transduct Target Ther 5:209","journal-title":"Signal Transduct Target Ther"},{"key":"1485_CR105","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioorg.2019.103417","volume":"94","author":"L Yuan","year":"2020","unstructured":"Yuan L, Zou C, Ge W, Liu Y, Hu B, Wang J, Lin B, Li Y, Ma E (2020) A novel cathepsin L inhibitor prevents the progression of idiopathic pulmonary fibrosis. Bioorg Chem 94:103417","journal-title":"Bioorg Chem"},{"key":"1485_CR106","doi-asserted-by":"publisher","first-page":"1284","DOI":"10.1248\/bpb.b16-00046","volume":"39","author":"H Zhan","year":"2016","unstructured":"Zhan H, Huang F, Ma W, Zhao Z, Zhang H, Zhang C (2016) Protective effect of ginsenoside Rg1 on bleomycin-induced pulmonary fibrosis in rats: involvement of caveolin-1 and TGF-beta1 signal pathway. Biol Pharm Bull 39:1284\u20131292","journal-title":"Biol Pharm Bull"},{"key":"1485_CR107","doi-asserted-by":"publisher","first-page":"022129","DOI":"10.1101\/cshperspect.a022129","volume":"9","author":"YE Zhang","year":"2017","unstructured":"Zhang YE (2017) Non-smad signaling pathways of the TGF-\u03b2 family. Cold Spring Harbor Perspect Biol 9:022129","journal-title":"Cold Spring Harbor Perspect Biol"},{"key":"1485_CR108","doi-asserted-by":"publisher","first-page":"752","DOI":"10.1016\/j.clnu.2014.08.014","volume":"34","author":"YQ Zhang","year":"2015","unstructured":"Zhang YQ, Liu YJ, Mao YF, Dong WW, Zhu XY, Jiang L (2015) Resveratrol ameliorates lipopolysaccharide-induced epithelial mesenchymal transition and pulmonary fibrosis through suppression of oxidative stress and transforming growth factor-beta1 signaling. Clin Nutr 34:752\u2013760","journal-title":"Clin Nutr"},{"key":"1485_CR109","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1038\/s41419-017-0198-x","volume":"9","author":"Z Zhang","year":"2018","unstructured":"Zhang Z, Qu J, Zheng C, Zhang P, Zhou W, Cui W, Mo X, Li L, Xu L, Gao J (2018) Nrf2 antioxidant pathway suppresses Numb-mediated epithelial-mesenchymal transition during pulmonary fibrosis. Cell Death Dis 9:83","journal-title":"Cell Death Dis"},{"key":"1485_CR110","doi-asserted-by":"publisher","first-page":"111072","DOI":"10.1016\/j.biopha.2020.111072","volume":"133","author":"Y Zhang","year":"2021","unstructured":"Zhang Y, Lu P, Qin H, Zhang Y, Sun X, Song X, Liu J, Peng H, Liu Y, Nwafor EO, Li J, Liu Z (2021) Traditional Chinese medicine combined with pulmonary drug delivery system and idiopathic pulmonary fibrosis: Rationale and therapeutic potential. Biomed Pharmacother 133:111072","journal-title":"Biomed Pharmacother"},{"key":"1485_CR111","first-page":"2321","volume":"21","author":"H Zhao","year":"2020","unstructured":"Zhao H, Li C, Li L, Liu J, Gao Y, Mu K, Chen D, Lu A, Ren Y, Li Z (2020) Baicalin alleviates bleomycin-induced pulmonary fibrosis and fibroblast proliferation in rats via the PI3K\/AKT signaling pathway. Mol Med Rep 21:2321\u20132334","journal-title":"Mol Med Rep"},{"key":"1485_CR112","doi-asserted-by":"publisher","first-page":"1096","DOI":"10.1172\/JCI66700","volume":"123","author":"Y Zhou","year":"2013","unstructured":"Zhou Y, Huang X, Hecker L, Kurundkar D, Kurundkar A, Liu H, Jin TH, Desai L, Bernard K, Thannickal VJ (2013) Inhibition of mechanosensitive signaling in myofibroblasts ameliorates experimental pulmonary fibrosis. J Clin Invest 123:1096\u20131108","journal-title":"J Clin Invest"},{"key":"1485_CR113","doi-asserted-by":"publisher","first-page":"961","DOI":"10.1002\/ptr.5083","volume":"28","author":"YX Zhou","year":"2014","unstructured":"Zhou YX, Zhang H, Peng C (2014) Puerarin: a review of pharmacological effects. Phytother Res 28:961\u2013975","journal-title":"Phytother Res"},{"key":"1485_CR114","doi-asserted-by":"publisher","first-page":"2734","DOI":"10.1021\/acschembio.2c00099","volume":"17","author":"Y Zhou","year":"2022","unstructured":"Zhou Y, Li M, Shen T, Yang T, Shi G, Wei Y, Chen C, Wang D, Wang Y, Zhang T (2022) Celastrol targets cullin-associated and neddylation-dissociated 1 to prevent fibroblast-myofibroblast transformation against pulmonary fibrosis. ACS Chem Biol 17:2734\u20132743","journal-title":"ACS Chem Biol"},{"key":"1485_CR115","doi-asserted-by":"publisher","first-page":"23581","DOI":"10.3390\/ijms141223581","volume":"14","author":"T Zhu","year":"2013","unstructured":"Zhu T, Zhang W, Xiao M, Chen H, Jin H (2013) Protective role of andrographolide in bleomycin-induced pulmonary fibrosis in mice. Int J Mol Sci 14:23581\u201323596","journal-title":"Int J Mol Sci"},{"key":"1485_CR116","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1016\/j.ejmech.2018.01.097","volume":"147","author":"J Zou","year":"2018","unstructured":"Zou J, Gao P, Hao X, Xu H, Zhan P, Liu X (2018) Recent progress in the structural modification and pharmacological activities of ligustrazine derivatives. Eur J Med Chem 147:150\u2013162","journal-title":"Eur J Med Chem"},{"key":"1485_CR117","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexcr.2020.111886","volume":"391","author":"M Zou","year":"2020","unstructured":"Zou M, Zhang G, Zou J, Liu Y, Liu B, Hu X, Cheng Z (2020) Inhibition of the ERK1\/2-ubiquitous calpains pathway attenuates experimental pulmonary fibrosis in vivo and in vitro. Exp Cell Res 391:111886","journal-title":"Exp Cell Res"}],"container-title":["Inflammopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10787-024-01485-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10787-024-01485-0","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10787-024-01485-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T10:02:27Z","timestamp":1783504947000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10787-024-01485-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5,9]]},"references-count":117,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2024,8]]}},"alternative-id":["1485"],"URL":"https:\/\/doi.org\/10.1007\/s10787-024-01485-0","relation":{},"ISSN":["0925-4692","1568-5608"],"issn-type":[{"value":"0925-4692","type":"print"},{"value":"1568-5608","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,5,9]]},"assertion":[{"value":"9 January 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 April 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 May 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors have not disclosed any competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}