{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T19:40:31Z","timestamp":1785526831628,"version":"3.56.0"},"reference-count":69,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2024,8,10]],"date-time":"2024-08-10T00:00:00Z","timestamp":1723248000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,8,10]],"date-time":"2024-08-10T00:00:00Z","timestamp":1723248000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100023981","name":"CSIR-North East Institute of Science and Technology","doi-asserted-by":"publisher","award":["OLP 2083"],"award-info":[{"award-number":["OLP 2083"]}],"id":[{"id":"10.13039\/501100023981","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Inflammopharmacol"],"published-print":{"date-parts":[[2024,10]]},"DOI":"10.1007\/s10787-024-01539-3","type":"journal-article","created":{"date-parts":[[2024,8,10]],"date-time":"2024-08-10T09:02:31Z","timestamp":1723280551000},"page":"3411-3428","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Anti-inflammatory potential of Piper betleoides C. DC., a promising Piper species of Northeast India: in vitro and in vivo evidence and mechanistic insight"],"prefix":"10.1007","volume":"32","author":[{"given":"Rikraj","family":"Loying","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bhaben","family":"Sharmah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiranmoy","family":"Barman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anupriya","family":"Borah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Himangsu Kousik","family":"Bora","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jatin","family":"Kalita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1952-6531","authenticated-orcid":false,"given":"Prasenjit","family":"Manna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,8,10]]},"reference":[{"key":"1539_CR1","doi-asserted-by":"publisher","first-page":"592","DOI":"10.2174\/1570159X11311060003","volume":"11","author":"F Amaya","year":"2013","unstructured":"Amaya F, Izumi Y, Matsuda M, Sasaki M (2013) Tissue injury and related mediators of pain exacerbation. Curr Neuropharmacol 11:592\u2013597","journal-title":"Curr Neuropharmacol"},{"key":"1539_CR2","first-page":"40","volume":"2","author":"MD Anju Jaishi","year":"2015","unstructured":"Anju Jaishi MD, Purba JS, Hirendra NS (2015) Secondary root extract of Piper Betleoides causes changes in structural organization of graafian follicle and uterine epithelium in rat during estrus and early gestational period. J Bioresour 2:40\u201349","journal-title":"J Bioresour"},{"key":"1539_CR3","first-page":"41","volume":"2","author":"B Bak\u0131r","year":"2008","unstructured":"Bak\u0131r B, Him A, \u00d6zbek H, D\u00fcz E, T\u00fct\u00fcnc\u00fc M (2008) Investigation of the anti-inflammatory and analgesic activities of \u03b2-caryophyllene. Int J Essent Oil Ther 2:41\u201344","journal-title":"Int J Essent Oil Ther"},{"key":"1539_CR4","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1111\/j.1365-3083.2008.02096.x","volume":"67","author":"M Berglund","year":"2008","unstructured":"Berglund M, Thomas J, H\u00f6rnquist E, Hultgren OH (2008) Toll-like receptor cross-hyporesponsiveness is functional in interleukin-1-receptor-associated kinase-1 (IRAK-1)-deficient macrophages: differential role played by IRAK-1 in regulation of tumour necrosis factor and interleukin-10 production. Scand J Immunol 67:473\u2013479","journal-title":"Scand J Immunol"},{"key":"1539_CR5","doi-asserted-by":"publisher","first-page":"3083","DOI":"10.1111\/jcmm.17323","volume":"26","author":"P Biswas","year":"2022","unstructured":"Biswas P, Anand U, Saha SC, Kant N, Mishra T, Masih H, Bar A, Pandey DK, Jha NK, Majumder M (2022a) Betelvine (Piper betle L.): a comprehensive insight into its ethnopharmacology, phytochemistry, and pharmacological, biomedical and therapeutic attributes. J Cell Mol Med 26:3083\u20133119","journal-title":"J Cell Mol Med"},{"key":"1539_CR6","doi-asserted-by":"publisher","first-page":"4425","DOI":"10.1002\/ptr.7649","volume":"36","author":"P Biswas","year":"2022","unstructured":"Biswas P, Ghorai M, Mishra T, Gopalakrishnan AV, Roy D, Mane AB, Mundhra A, Das N, Mohture VM, Patil MT (2022b) Piper longum L.: a comprehensive review on traditional uses, phytochemistry, pharmacology, and health-promoting activities. Phytother Res 36:4425\u20134476","journal-title":"Phytother Res"},{"key":"1539_CR7","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1016\/j.jnutbio.2019.05.006","volume":"70","author":"J Bordoloi","year":"2019","unstructured":"Bordoloi J, Ozah D, Bora T, Kalita J, Manna P (2019) Gamma-glutamyl carboxylated Gas6 mediates the beneficial effect of vitamin K on lowering hyperlipidemia via regulating the AMPK\/SREBP1\/PPAR\u03b1 signaling cascade of lipid metabolism. J Nutr Biochem 70:174\u2013184","journal-title":"J Nutr Biochem"},{"key":"1539_CR8","doi-asserted-by":"publisher","first-page":"1107","DOI":"10.1021\/acs.jnatprod.9b01116","volume":"83","author":"AM Carvalho","year":"2020","unstructured":"Carvalho AM, Heimfarth L, Pereira EWM, Oliveira FS, Menezes IR, Coutinho HD, Picot L, Antoniolli AR, Quintans JS, Quintans-J\u00fanior LJ (2020) Phytol, a chlorophyll component, produces antihyperalgesic, anti-inflammatory, and antiarthritic effects: possible NF\u03baB pathway involvement and reduced levels of the proinflammatory cytokines TNF-\u03b1 and IL-6. J Nat Prod 83:1107\u20131117","journal-title":"J Nat Prod"},{"key":"1539_CR9","first-page":"6","volume":"1","author":"SS Dahham","year":"2015","unstructured":"Dahham SS, Tabana YM, Ahamed MBK, Majid A (2015) In vivo anti-inflammatory activity of \u03b2-caryophyllene, evaluated by molecular imaging. Mol Med Chem 1:6","journal-title":"Mol Med Chem"},{"key":"1539_CR10","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1007\/978-3-319-41334-1_8","volume":"2016","author":"G Derosa","year":"2016","unstructured":"Derosa G, Maffioli P, Sahebkar A (2016) Piperine and its role in chronic diseases. Adv Exp Med Biol 2016:173\u2013184","journal-title":"Adv Exp Med Biol"},{"key":"1539_CR11","doi-asserted-by":"publisher","DOI":"10.1201\/9781420040463","volume-title":"Handbook of medicinal herbs","author":"JA Duke","year":"2002","unstructured":"Duke JA (2002) Handbook of medicinal herbs. CRC Press"},{"key":"1539_CR12","doi-asserted-by":"publisher","DOI":"10.1007\/978-0-387-30599-8","volume-title":"Piper: a model genus for studies of phytochemistry, ecology, and evolution","author":"LA Dyer","year":"2004","unstructured":"Dyer LA, Palmer AD (2004) Piper: a model genus for studies of phytochemistry, ecology, and evolution. Springer"},{"key":"1539_CR13","volume-title":"Plant resources of South-East Asia (PROSEA) No. 9: plants yielding non-seed carbohydrates","author":"M Flach","year":"1996","unstructured":"Flach M, Rumawas F (1996) Plant resources of South-East Asia (PROSEA) No. 9: plants yielding non-seed carbohydrates. Blackhuys, Leyden"},{"key":"1539_CR14","volume-title":"World checklist of cyperaceae","author":"R Govaerts","year":"2015","unstructured":"Govaerts R, Jim\u00e9nez-Mej\u00edas P, Koopman J, Simpson D, Goetghebeur P, Wilson K, Egorova T, Bruhl J (2015) World checklist of cyperaceae. Royal Botanic Gardens, Kew"},{"key":"1539_CR15","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2024.155859","author":"S Guo","year":"2024","unstructured":"Guo S, Zhang J, Zhang Q, Xu S, Liu Y, Ma S, Hu X, Liu Y, Zhang X, Jiang R, Zhang Z (2024) Polygala tenuifolia willd. extract alleviates LPS-induced acute lung injury in rats via TLR4\/NF-\u03baB pathway and NLRP3 inflammasome suppression. Phytomed. https:\/\/doi.org\/10.1016\/j.phymed.2024.155859","journal-title":"Phytomed"},{"key":"1539_CR16","doi-asserted-by":"publisher","first-page":"756","DOI":"10.3390\/s6070756","volume":"6","author":"XJ Huang","year":"2006","unstructured":"Huang XJ, Choi YK, Im HS, Yarimaga O, Yoon E, Kim HS (2006) Aspartate aminotransferase (AST\/GOT) and alanine aminotransferase (ALT\/GPT) detection techniques. Sensors 6:756\u2013782","journal-title":"Sensors"},{"issue":"3","key":"1539_CR17","doi-asserted-by":"publisher","first-page":"1957","DOI":"10.1021\/ac303787p","volume":"85","author":"RA Hunter","year":"2013","unstructured":"Hunter RA, Storm WL, Coneski PN, Schoenfisch MH (2013) Inaccuracies of nitric oxide measurement methods in biological media. Anal Chem 85(3):1957\u20131963","journal-title":"Anal Chem"},{"key":"1539_CR18","doi-asserted-by":"publisher","first-page":"1025","DOI":"10.1007\/s10753-016-0332-4","volume":"39","author":"A Jangra","year":"2016","unstructured":"Jangra A, Kwatra M, Singh T, Pant R, Kushwah P, Sharma Y, Saroha B, Datusalia AK, Bezbaruah BK (2016) Piperine augments the protective effect of curcumin against lipopolysaccharide-induced neurobehavioral and neurochemical deficits in mice. Inflammation 39:1025\u20131038","journal-title":"Inflammation"},{"key":"1539_CR19","doi-asserted-by":"publisher","first-page":"1097","DOI":"10.3389\/fimmu.2020.01097","volume":"11","author":"V Jaumouill\u00e9","year":"2020","unstructured":"Jaumouill\u00e9 V, Waterman CM (2020) Physical constraints and forces involved in phagocytosis. Front Immunol 11:1097","journal-title":"Front Immunol"},{"key":"1539_CR20","doi-asserted-by":"publisher","first-page":"533","DOI":"10.1038\/nrd4334","volume":"13","author":"RR Ji","year":"2014","unstructured":"Ji RR, Xu ZZ, Gao YJ (2014) Emerging targets in neuroinflammation-driven chronic pain. Nat Rev Drug Discov 13:533\u2013548","journal-title":"Nat Rev Drug Discov"},{"key":"1539_CR21","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1038\/35093019","volume":"413","author":"D Julius","year":"2001","unstructured":"Julius D, Basbaum AI (2001) Molecular mechanisms of nociception. Nat 413:203\u2013210","journal-title":"Nat"},{"key":"1539_CR22","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1002\/ffj.3537","volume":"35","author":"P Kemprai","year":"2020","unstructured":"Kemprai P, Bora PK, Mahanta BP, Sut D, Saikia SP, Banik D, Haldar S (2020) Piper betleoides C. DC.: edible source of betel-scented sesquiterpene-rich essential oil. Flavour Fragr J 35:70\u201378","journal-title":"Flavour Fragr J"},{"key":"1539_CR23","doi-asserted-by":"publisher","first-page":"4606459","DOI":"10.1155\/2017\/4606459","volume":"2017","author":"YJ Kim","year":"2017","unstructured":"Kim YJ, Deok J, Kim S, Yoon DH, Sung GH, Aravinthan A, Lee S, Lee MN, Hong S, Kim JH (2017) Anti-inflammatory effect of Piper attenuatum methanol extract in LPS-stimulated inflammatory responses. Evid-Based Complement Alter Med 2017:4606459","journal-title":"Evid-Based Complement Alter Med"},{"key":"1539_CR24","first-page":"922","volume":"99","author":"N Kumar","year":"2010","unstructured":"Kumar N, Misra P, Dube A, Bhattacharya S, Dikshit M, Ranade S (2010) Piper betle Linn. a maligned pan-Asiatic plant with an array of pharmacological activities and prospects for drug discovery. Curr Sci 99:922\u2013932","journal-title":"Curr Sci"},{"key":"1539_CR25","doi-asserted-by":"publisher","first-page":"504","DOI":"10.1016\/j.etap.2014.12.021","volume":"39","author":"A Kumar","year":"2015","unstructured":"Kumar A, Sasmal D, Sharma N (2015) Immunomodulatory role of piperine in deltamethrin induced thymic apoptosis and altered immune functions. Environ Toxicol Pharmacol 39:504\u2013514","journal-title":"Environ Toxicol Pharmacol"},{"key":"1539_CR26","doi-asserted-by":"publisher","first-page":"104762","DOI":"10.1016\/j.yrtph.2020.104762","volume":"117","author":"MM Leitao","year":"2020","unstructured":"Leitao MM, Radai JA, Ferrari IC, Negrao FJ, Silva-Filho SE, Oliveira RJ, Mota JDS, Kassuya CA (2020) Effects of an ethanolic extract and fractions from Piper glabratum (Piperaceae) leaves on pain and inflammation. Regul Toxicol Pharmacol 117:104762","journal-title":"Regul Toxicol Pharmacol"},{"issue":"3","key":"1539_CR27","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1080\/15548627.2021.1937897","volume":"18","author":"R Li","year":"2022","unstructured":"Li R, Lu Y, Zhang Q, Liu W, Yang R, Jiao J, Liu J, Gao G, Yang H (2022) Piperine promotes autophagy flux by P2RX4 activation in SNCA\/\u03b1-synuclein-induced Parkinson disease model. Autophagy 18(3):559\u2013575","journal-title":"Autophagy"},{"issue":"11","key":"1539_CR28","doi-asserted-by":"publisher","first-page":"6067","DOI":"10.1073\/pnas.1904532117","volume":"117","author":"WC Liang","year":"2020","unstructured":"Liang WC, Ren JL, Yu QX, Li J, Ng TK, Chu WK, Qin YJ, Chu KO, Schally AV, Pang CP, Chan SO (2020) Signaling mechanisms of growth hormone-releasing hormone receptor in LPS-induced acute ocular inflammation. Proc Nat Acad Sci 117(11):6067\u20136074","journal-title":"Proc Nat Acad Sci"},{"key":"1539_CR29","doi-asserted-by":"publisher","first-page":"1374","DOI":"10.3390\/molecules21101374","volume":"21","author":"D Lin","year":"2016","unstructured":"Lin D, Xiao M, Zhao J, Li Z, Xing B, Li X, Kong M, Li L, Zhang Q, Liu Y (2016) An overview of plant phenolic compounds and their importance in human nutrition and management of type 2 diabetes. Molecules 21:1374","journal-title":"Molecules"},{"issue":"5","key":"1539_CR30","doi-asserted-by":"publisher","first-page":"411","DOI":"10.3390\/life11050411","volume":"11","author":"CY Lin","year":"2021","unstructured":"Lin CY, Kao SH, Hung LC, Chien HJ, Wang WH, Chang YW, Chen YH (2021) Lipopolysaccharide-induced nitric oxide and prostaglandin E2 production is inhibited by tellimagrandin II in mouse and human macrophages. Life 11(5):411","journal-title":"Life"},{"key":"1539_CR31","doi-asserted-by":"publisher","first-page":"1642","DOI":"10.3390\/antiox10101642","volume":"10","author":"SV Luca","year":"2021","unstructured":"Luca SV, Gawe\u0142-B\u0119ben K, Strz\u0119pek-Gom\u00f3\u0142ka M, Czech K, Trifan A, Zengin G, Korona-Glowniak I, Minceva M, Gertsch J, Skalicka-Wo\u017aniak K (2021) Insights into the phytochemical and multifunctional biological profile of spices from the genus Piper. Antioxidants 10:1642","journal-title":"Antioxidants"},{"key":"1539_CR32","doi-asserted-by":"publisher","first-page":"118462","DOI":"10.1016\/j.jep.2024.118462","volume":"333","author":"X Lv","year":"2024","unstructured":"Lv X, Xie Z, Wang H, Lu G, Li M, Chen D, Lin T, Jiang C (2024) In vivo and in vitro anti-inflammation of rhapontici radix extract on mastitis via TMEM59 and GPR161. J Ethnopharmacol 333:118462","journal-title":"J Ethnopharmacol"},{"key":"1539_CR33","doi-asserted-by":"publisher","first-page":"2609","DOI":"10.1002\/ptr.6715","volume":"34","author":"M Madhumita","year":"2020","unstructured":"Madhumita M, Guha P, Nag A (2020) Bio-actives of betel leaf (Piper betle L.): a comprehensive review on extraction, isolation, characterization, and biological activity. Phytother Res 34:2609\u20132627","journal-title":"Phytother Res"},{"key":"1539_CR34","doi-asserted-by":"publisher","first-page":"1747","DOI":"10.1007\/s00436-011-2695-7","volume":"110","author":"LG Magalh\u00e3es","year":"2012","unstructured":"Magalh\u00e3es LG, de Souza JM, Wakabayashi KA, da Laurentiz SR, Vinh\u00f3lis AH, Rezende KC, Simaro GV, Bastos JK, Rodrigues V, Esperandim VR (2012) In vitro efficacy of the essential oil of Piper cubeba L. (Piperaceae) against Schistosoma mansoni. Parasitol Res 110:1747\u20131754","journal-title":"Parasitol Res"},{"issue":"46","key":"1539_CR35","doi-asserted-by":"publisher","first-page":"39848","DOI":"10.1074\/jbc.M111.270884","volume":"286","author":"P Manna","year":"2011","unstructured":"Manna P, Jain SK (2011) Hydrogen sulfide and L-cysteine increase phosphatidylinositol 3, 4, 5-trisphosphate (PIP3) and glucose utilization by inhibiting phosphatase and tensin homolog (PTEN) protein and activating phosphoinositide 3-kinase (PI3K)\/serine\/threonine protein kinase (AKT)\/protein kinase C\u03b6\/\u03bb (PKC\u03b6\/\u03bb) in 3T3l1 adipocytes. J Biol Chem 286(46):39848\u201339859","journal-title":"J Biol Chem"},{"issue":"10","key":"1539_CR36","doi-asserted-by":"publisher","first-page":"2334","DOI":"10.1002\/jcb.24578","volume":"114","author":"P Manna","year":"2013","unstructured":"Manna P, Jain SK (2013) L-cysteine and hydrogen sulfide increase PIP3 and AMPK\/PPAR\u03b3 expression and decrease ROS and vascular inflammation markers in high glucose treated human U937 monocytes. J Cell Biochem 114(10):2334\u20132345","journal-title":"J Cell Biochem"},{"key":"1539_CR37","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1016\/j.sajb.2017.05.007","volume":"112","author":"EE Mgbeahuruike","year":"2017","unstructured":"Mgbeahuruike EE, Yrj\u00f6nen T, Vuorela H, Holm Y (2017) Bioactive compounds from medicinal plants: focus on Piper species. S Afr J Bot 112:54\u201369","journal-title":"S Afr J Bot"},{"key":"1539_CR38","doi-asserted-by":"publisher","first-page":"240","DOI":"10.1128\/CMR.00046-08","volume":"22","author":"TH Mogensen","year":"2009","unstructured":"Mogensen TH (2009) Pathogen recognition and inflammatory signaling in innate immune defenses. Clin Microbiol Rev 22:240\u2013273","journal-title":"Clin Microbiol Rev"},{"key":"1539_CR39","doi-asserted-by":"publisher","first-page":"1021","DOI":"10.1016\/j.jep.2010.11.037","volume":"133","author":"S Mohamad","year":"2011","unstructured":"Mohamad S, Zin NM, Wahab HA, Ibrahim P, Sulaiman SF, Zahariluddin ASM, Noor SSM (2011) Antituberculosis potential of some ethnobotanically selected Malaysian plants. J Ethnopharmacol 133:1021\u20131026","journal-title":"J Ethnopharmacol"},{"key":"1539_CR40","doi-asserted-by":"publisher","first-page":"1348","DOI":"10.1007\/s10753-012-9448-3","volume":"35","author":"V Murunikkara","year":"2012","unstructured":"Murunikkara V, Pragasam SJ, Kodandaraman G, Sabina EP, Rasool M (2012) Anti-inflammatory effect of piperine in adjuvant-induced arthritic rats\u2014a biochemical approach. Inflammation 35:1348\u20131356","journal-title":"Inflammation"},{"key":"1539_CR41","first-page":"2991","volume":"4","author":"K Nagori","year":"2011","unstructured":"Nagori K, Singh MK, Alexander A, Kumar T, Dewangan D, Badwaik H, Tripathi D (2011) Piper betle L.: a review on its ethnobotany, phytochemistry, pharmacological profile and profiling by new hyphenated technique DART-MS (direct analysis in real time mass spectrometry). J Pharm Res 4:2991\u20132997","journal-title":"J Pharm Res"},{"key":"1539_CR42","doi-asserted-by":"publisher","first-page":"5473","DOI":"10.1007\/s12035-021-02497-5","volume":"58","author":"R Nasrnezhad","year":"2021","unstructured":"Nasrnezhad R, Halalkhor S, Sadeghi F, Pourabdolhossein F (2021) Piperine improves experimental autoimmune encephalomyelitis (EAE) in lewis rats through its neuroprotective, anti-inflammatory, and antioxidant effects. Mol Neurobiol 58:5473\u20135493","journal-title":"Mol Neurobiol"},{"key":"1539_CR43","doi-asserted-by":"publisher","first-page":"3439","DOI":"10.3390\/ijms21103439","volume":"21","author":"TQ Nguyen","year":"2020","unstructured":"Nguyen TQ, Duy Binh T, Pham TL, Nguyen YD, Dai Trang TX, Nguyen TT, Kanaori K, Kamei K (2020) Anti-inflammatory effects of Lasia spinosa leaf extract in lipopolysaccharide-induced RAW 2647 macrophages. Int J Mol Sci 21:3439","journal-title":"Int J Mol Sci"},{"key":"1539_CR44","first-page":"277","volume":"22","author":"E Okoro","year":"2023","unstructured":"Okoro E (2023) Ameliorative effects of Cnestis ferruginea root extract on carbon tetrachloride nephrotoxicity in albino Wistar rats. Sci Afr 22:277\u2013286","journal-title":"Sci Afr"},{"key":"1539_CR45","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1016\/j.etap.2009.02.003","volume":"28","author":"N Pathak","year":"2009","unstructured":"Pathak N, Khandelwal S (2009) Immunomodulatory role of piperine in cadmium induced thymic atrophy and splenomegaly in mice. Environ Toxicol Pharmacol 28:52\u201360","journal-title":"Environ Toxicol Pharmacol"},{"key":"1539_CR46","doi-asserted-by":"publisher","first-page":"54722","DOI":"10.1371\/journal.pone.0054722","volume":"8","author":"A Di Penta","year":"2013","unstructured":"Di Penta A, Moreno B, Reix S, Fernandez-Diez B, Villanueva M, Errea O, Escala N, Vandenbroeck K, Comella JX, Villoslada P (2013) Oxidative stress and proinflammatory cytokines contribute to demyelination and axonal damage in a cerebellar culture model of neuroinflammation. PLoS ONE 8:54722","journal-title":"PLoS ONE"},{"key":"1539_CR47","doi-asserted-by":"publisher","first-page":"406","DOI":"10.1002\/jcp.22289","volume":"225","author":"KJ Porter","year":"2010","unstructured":"Porter KJ, Gonipeta B, Parvataneni S, Appledorn DM, Patial S, Sharma D, Gangur V, Amalfitano A, Parameswaran N (2010) Regulation of lipopolysaccharide-induced inflammatory response and endotoxemia by \u03b2-arrestins. J Cell Physiol 225:406\u2013416","journal-title":"J Cell Physiol"},{"key":"1539_CR48","doi-asserted-by":"publisher","first-page":"100063","DOI":"10.1016\/j.crimmu.2023.100063","volume":"4","author":"M Rafiyan","year":"2023","unstructured":"Rafiyan M, Sadeghmousavi S, Akbarzadehmoallemkolaei M, Rezaei N (2023) Experimental animal models of chronic inflammation. Curr Res Immunol 4:100063","journal-title":"Curr Res Immunol"},{"key":"1539_CR49","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1016\/j.jff.2015.04.034","volume":"16","author":"M Rana","year":"2015","unstructured":"Rana M, Reddy SS, Maurya P, Singh V, Chaturvedi S, Kaur K, Agarwal H, Ahmad H, Naqvi A, Dwivedi AK, Dikshit M (2015) Turmerone enriched standardized Curcuma longa extract alleviates LPS induced inflammation and cytokine production by regulating TLR4\u2013IRAK1\u2013ROS\u2013MAPK\u2013NF\u03baB axis. J Funct Foods 16:152\u2013163","journal-title":"J Funct Foods"},{"key":"1539_CR50","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1159\/000324009","volume":"17","author":"JA Russell","year":"2011","unstructured":"Russell JA, Boyd J, Nakada T, Thair S, Walley KR (2011) Molecular mechanisms of sepsis. Sepsis-pro-Inflamm Anti-Inflamm Res 17:48\u201385","journal-title":"Sepsis-pro-Inflamm Anti-Inflamm Res"},{"key":"1539_CR51","first-page":"127","volume":"7","author":"G Saha","year":"2013","unstructured":"Saha G, Biswas R, Das A (2013) Survey of medicinal plants in the Gorumara national park, Jalpaiguri, West Bengal, India. Pleione 7:127\u2013137","journal-title":"Pleione"},{"key":"1539_CR52","doi-asserted-by":"publisher","first-page":"89","DOI":"10.21010\/ajtcam.v14i1.10","volume":"14","author":"A Sanubol","year":"2017","unstructured":"Sanubol A, Chaveerach A, Tanee T, Sudmoon R (2017) Pre-clinical evaluation of extracts and essential oils from betel-like scent Piper species identified potential cancer treatment. Afr J Trad Complement Alter Med 14:89\u2013102","journal-title":"Afr J Trad Complement Alter Med"},{"key":"1539_CR53","doi-asserted-by":"publisher","first-page":"878","DOI":"10.1016\/j.bbamcr.2011.01.034","volume":"1813","author":"J Scheller","year":"2011","unstructured":"Scheller J, Chalaris A, Schmidt-Arras D, Rose-John S (2011) The pro-and anti-inflammatory properties of the cytokine interleukin-6. Biochim Biophys Acta (BBA) Mol Cell Res 1813:878\u2013888","journal-title":"Biochim Biophys Acta (BBA) Mol Cell Res"},{"key":"1539_CR54","doi-asserted-by":"publisher","first-page":"1361","DOI":"10.1038\/nn1992","volume":"10","author":"J Scholz","year":"2007","unstructured":"Scholz J, Woolf CJ (2007) The neuropathic pain triad: neurons, immune cells and glia. Nat Neurosci 10:1361\u20131368","journal-title":"Nat Neurosci"},{"key":"1539_CR55","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1016\/j.ejphar.2015.04.057","volume":"785","author":"J Schumann","year":"2016","unstructured":"Schumann J (2016) It is all about fluidity: fatty acids and macrophage phagocytosis. Eur J Pharmacol 785:18\u201323","journal-title":"Eur J Pharmacol"},{"key":"1539_CR57","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1080\/10496475.2013.818606","volume":"19","author":"P Sharkar","year":"2013","unstructured":"Sharkar P, Rahman MM, Haque Masum GZ, Nayeem MA, Hossen MM, Azad AK (2013) Ethnomedicinal importance of the plants in villages in Kushtia Sador and Mirpur Upozila, Bangladesh. J Herbs Spices Med Plants 19:401\u2013417","journal-title":"J Herbs Spices Med Plants"},{"key":"1539_CR58","doi-asserted-by":"publisher","first-page":"252","DOI":"10.1007\/s10787-007-0013-x","volume":"15","author":"JN Sharma","year":"2007","unstructured":"Sharma JN, Al-Omran A, Parvathy SS (2007) Role of nitric oxide in inflammatory diseases. Inflammopharmacology 15:252\u2013259","journal-title":"Inflammopharmacology"},{"key":"1539_CR59","doi-asserted-by":"publisher","first-page":"818326","DOI":"10.3389\/fphar.2021.818326","volume":"12","author":"J Shi","year":"2022","unstructured":"Shi J, Xia Y, Wang H, Yi Z, Zhang R, Zhang X (2022) Piperlongumine is an NLRP3 inhibitor with anti-inflammatory activity. Front Pharmacol 12:818326","journal-title":"Front Pharmacol"},{"key":"1539_CR60","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1111\/fcp.12049","volume":"28","author":"RO Silva","year":"2014","unstructured":"Silva RO, Sousa FBM, Damasceno SR, Carvalho NS, Silva VG, Oliveira FRM, Sousa DP, Arag\u00e3o KS, Barbosa AL, Freitas RM (2014) Phytol, a diterpene alcohol, inhibits the inflammatory response by reducing cytokine production and oxidative stress. Fundam Clin Pharmacol 28:455\u2013464","journal-title":"Fundam Clin Pharmacol"},{"key":"1539_CR61","doi-asserted-by":"publisher","first-page":"3153527","DOI":"10.1155\/2018\/3153527","volume":"2018","author":"AL Stefanson","year":"2018","unstructured":"Stefanson AL, Bakovic M (2018) Falcarinol is a potent inducer of heme oxygenase-1 and was more effective than sulforaphane in attenuating intestinal inflammation at diet-achievable doses. Oxid Me Cell Longev 2018:3153527","journal-title":"Oxid Me Cell Longev"},{"key":"1539_CR62","doi-asserted-by":"publisher","DOI":"10.13057\/asianjethnobiol\/y030204","author":"M Taram","year":"2020","unstructured":"Taram M, Borah D, Mipun P, Taram V, Das AP (2020) Evaluation of ethnobotanical knowledge in Komkar-Adi biocultural landscape of Eastern Himalayan Region of India. Asian J Ethnobiol. https:\/\/doi.org\/10.13057\/asianjethnobiol\/y030204","journal-title":"Asian J Ethnobiol"},{"key":"1539_CR63","doi-asserted-by":"publisher","first-page":"400","DOI":"10.3923\/ijp.2007.400.405","volume":"3","author":"Y Vaghasiya","year":"2007","unstructured":"Vaghasiya Y, Nair R, Chanda S (2007) Investigation of some piper species for anti\u2014bacterial and anti\u2014inflammatory property. Int J Pharmacol 3:400\u2013405","journal-title":"Int J Pharmacol"},{"key":"1539_CR64","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/B978-0-12-380995-7.00001-X","volume":"108","author":"AF Valledor","year":"2010","unstructured":"Valledor AF, Comalada M, Santamar\u00eda-Babi LF, Lloberas J, Celada A (2010) Macrophage proinflammatory activation and deactivation: a question of balance. Adv Immunol 108:1\u201320","journal-title":"Adv Immunol"},{"key":"1539_CR65","doi-asserted-by":"publisher","first-page":"834","DOI":"10.1038\/nrd1852","volume":"4","author":"FA White","year":"2005","unstructured":"White FA, Bhangoo SK, Miller RJ (2005) Chemokines: integrators of pain and inflammation. Nat Rev Drug Discov 4:834\u2013844","journal-title":"Nat Rev Drug Discov"},{"key":"1539_CR66","doi-asserted-by":"publisher","first-page":"956","DOI":"10.1007\/s10753-014-9816-2","volume":"37","author":"X Xu","year":"2014","unstructured":"Xu X, Yin P, Wan C, Chong X, Liu M, Cheng P, Chen J, Liu F, Xu J (2014) Punicalagin inhibits inflammation in LPS-induced RAW264. 7 macrophages via the suppression of TLR4-mediated MAPKs and NF-\u03baB activation. Inflammation 37:956\u2013965","journal-title":"Inflammation"},{"key":"1539_CR67","doi-asserted-by":"publisher","first-page":"380218","DOI":"10.1155\/2015\/380218","volume":"2015","author":"X Xu","year":"2015","unstructured":"Xu X, Li H, Hou X, Li D, He S, Wan C, Yin P, Liu M, Liu F, Xu J (2015) Punicalagin induces Nrf2\/HO-1 expression via upregulation of PI3K\/AKT pathway and inhibits LPS-induced oxidative stress in RAW264. 7 macrophages. Mediat Inflamm 2015:380218","journal-title":"Mediat Inflamm"},{"key":"1539_CR68","doi-asserted-by":"publisher","first-page":"559","DOI":"10.3390\/molecules21050559","volume":"21","author":"H Yuan","year":"2016","unstructured":"Yuan H, Ma Q, Ye L, Piao G (2016) The traditional medicine and modern medicine from natural products. Molecules 21:559","journal-title":"Molecules"},{"key":"1539_CR69","doi-asserted-by":"publisher","first-page":"8597208","DOI":"10.1155\/2016\/8597208","volume":"2016","author":"WJ Zhai","year":"2016","unstructured":"Zhai WJ, Zhang ZB, Xu NN, Guo YF, Qiu C, Li CY, Deng GZ, Guo MY (2016) Piperine plays an anti-inflammatory role in Staphylococcus aureus endometritis by inhibiting activation of NF-\u03baB and MAPK pathways in mice. Evid-Based Complement Alter Med 2016:8597208","journal-title":"Evid-Based Complement Alter Med"},{"issue":"2","key":"1539_CR70","doi-asserted-by":"publisher","first-page":"742","DOI":"10.1016\/j.foodchem.2012.02.172","volume":"134","author":"Y Zhong","year":"2012","unstructured":"Zhong Y, Chiou YS, Pan MH, Shahidi F (2012) Anti-inflammatory activity of lipophilic epigallocatechin gallate (EGCG) derivatives in LPS-stimulated murine macrophages. Food Chem 134(2):742\u2013748","journal-title":"Food Chem"}],"updated-by":[{"DOI":"10.1007\/s10787-026-02352-w","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T00:00:00Z","timestamp":1785283200000}}],"container-title":["Inflammopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10787-024-01539-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10787-024-01539-3","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10787-024-01539-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T18:03:45Z","timestamp":1785521025000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10787-024-01539-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8,10]]},"references-count":69,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2024,10]]}},"alternative-id":["1539"],"URL":"https:\/\/doi.org\/10.1007\/s10787-024-01539-3","relation":{},"ISSN":["0925-4692","1568-5608"],"issn-type":[{"value":"0925-4692","type":"print"},{"value":"1568-5608","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,8,10]]},"assertion":[{"value":"4 May 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 July 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 August 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 July 2026","order":5,"name":"change_date","label":"Change Date","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Correction","order":6,"name":"change_type","label":"Change Type","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"A Correction to this paper has been published:","order":7,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"https:\/\/doi.org\/10.1007\/s10787-026-02352-w","URL":"https:\/\/doi.org\/10.1007\/s10787-026-02352-w","order":8,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The author affirms that there are no conflicting financial interests or personal relationships that may have influenced the findings reported in this paper.","order":1,"name":"Ethics","label":"Conflict of interest","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This article includes the animal studies with proper ethical approval from Institutional Animal Ethical Committee.","order":2,"name":"Ethics","label":"Ethical approval","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All authors have seen the final manuscript and provided consent for its publication.","order":3,"name":"Ethics","label":"Consent for publication","group":{"name":"EthicsHeading","label":"Declarations"}}]}}