{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,25]],"date-time":"2026-10-25T00:50:08Z","timestamp":1792889408846,"version":"4.5.0"},"reference-count":118,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2024,8,10]],"date-time":"2024-08-10T00:00:00Z","timestamp":1723248000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,8,10]],"date-time":"2024-08-10T00:00:00Z","timestamp":1723248000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Inflammopharmacol"],"published-print":{"date-parts":[[2024,10]]},"DOI":"10.1007\/s10787-024-01544-6","type":"journal-article","created":{"date-parts":[[2024,8,10]],"date-time":"2024-08-10T07:02:32Z","timestamp":1723273352000},"page":"3499-3519","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Gastroprotective role of a flavonoid-rich subfraction from Fridericia chica (Bonpl.) L. G. Lohmann: a medicinal plant used in the Amazon region"],"prefix":"10.1007","volume":"32","author":[{"given":"Daniela","family":"Miorando","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda M.","family":"Steffler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristian A. Dalla","family":"Vecchia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Viviane L.","family":"Simomura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaqueline J.","family":"Veloso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maike V.","family":"Buzatto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruan K. S.","family":"Nunes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lincon B.","family":"Somensi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Max V.","family":"Guti\u00e9rrez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorane I. S. H.","family":"Melim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franco M. M.","family":"Pontes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luisa M.","family":"Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anzhela","family":"Veselinova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lola","family":"Gonz\u00e1lez-S\u00e1nchez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pablo G.","family":"Jambrina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8363-8795","authenticated-orcid":false,"given":"Walter A. Roman","family":"Junior","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,8,10]]},"reference":[{"key":"1544_CR1","doi-asserted-by":"publisher","first-page":"895","DOI":"10.1016\/j.biopha.2018.11.004","volume":"110","author":"A Abdeen","year":"2019","unstructured":"Abdeen A, Aboubakr M, Elgazzar D et al (2019) Rosuvastatin attenuates piroxicam-mediated gastric ulceration and hepato-renal toxicity in rats. Biomed Pharmacother 110:895\u2013905. https:\/\/doi.org\/10.1016\/j.biopha.2018.11.004","journal-title":"Biomed Pharmacother"},{"key":"1544_CR2","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1016\/S0076-6879(84)05016-3","volume":"105","author":"H Aebi","year":"1984","unstructured":"Aebi H (1984) Catalase in Vitro Methods in Enzimology 105:121\u2013126. https:\/\/doi.org\/10.1016\/S0076-6879(84)05016-3","journal-title":"Catalase in Vitro Methods in Enzimology"},{"key":"1544_CR3","doi-asserted-by":"publisher","DOI":"10.1038\/s41389-017-0025-3","author":"N Allocati","year":"2018","unstructured":"Allocati N, Masulli M, Di Ilio C et al (2018) Glutathione transferases: Substrates, inihibitors and pro-drugs in cancer and neurodegenerative diseases. Oncogenesis. https:\/\/doi.org\/10.1038\/s41389-017-0025-3","journal-title":"Oncogenesis"},{"issue":"1","key":"1544_CR4","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3390\/toxins15010036","volume":"15","author":"N Alvarez-Ortega","year":"2023","unstructured":"Alvarez-Ortega N, Caballero-Gallardo K, Juan C et al (2023) Cytoprotective, antiproliferative, and anti-oxidant potential of the hydroethanolic extract of fridericia chica leaves on human cancer cell lines exposed to \u03b1- and \u03b2-Zearalenol. Toxins 15(1):1\u201312. https:\/\/doi.org\/10.3390\/toxins15010036","journal-title":"Toxins"},{"issue":"2","key":"1544_CR5","doi-asserted-by":"publisher","first-page":"312","DOI":"10.1111\/j.1365-2249.2006.03207.x","volume":"146","author":"MC Andrade","year":"2006","unstructured":"Andrade MC, Menezes JS, Cassali GD et al (2006) Alcohol-induced gastritis prevents oral tolerance induction in mice. CEI 146(2):312\u2013322. https:\/\/doi.org\/10.1111\/j.1365-2249.2006.03207.x","journal-title":"CEI"},{"issue":"1","key":"1544_CR6","doi-asserted-by":"publisher","first-page":"21","DOI":"10.2174\/1871530322666220829142124","volume":"23","author":"AZ Ansari","year":"2023","unstructured":"Ansari AZ, Bhatia NY, Gharat SA et al (2023) Exploring cytokines as potential target in peptic ulcer disease: a systematic update. Endocr Metab Immune Disord Drug Targets 23(1):21\u201334. https:\/\/doi.org\/10.2174\/1871530322666220829142124","journal-title":"Endocr Metab Immune Disord Drug Targets"},{"issue":"1","key":"1544_CR7","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1085\/jgp.22.1.79","volume":"22","author":"ML Anson","year":"1938","unstructured":"Anson ML (1938) The estimation of pepsin, trypsin, papain, and cathepsin with hemoglobin. J Gen Physiol 22(1):79\u201389. https:\/\/doi.org\/10.1085\/jgp.22.1.79","journal-title":"J Gen Physiol"},{"key":"1544_CR8","unstructured":"Anvisa - Ag\u00eancia Nacional de Vigil\u00e2ncia Sanit\u00e1ria (2010) Farmacopeia Brasileira. https:\/\/antigo.anvisa.gov.br\/documents\/33832\/260079\/5%C2%AA+edi%C3%A7%C3%A3o+-+Volume+1\/4c530f86-fe83-4c4a-b907-6a96b5c2d2fc. Accessed 14 December 2023."},{"issue":"10","key":"1544_CR9","doi-asserted-by":"publisher","first-page":"905","DOI":"10.1055\/s-2003-45098","volume":"69","author":"J Arrieta","year":"2003","unstructured":"Arrieta J, Benitez J, Flores E et al (2003) Purification of gastroprotective triterpenoids from the stem bark of Amphipterygium adstringens; role of prostaglandins, sulfhydryls, nitric oxide and capsaicin-sensitive neurons. Planta Med 69(10):905\u2013909. https:\/\/doi.org\/10.1055\/s-2003-45098","journal-title":"Planta Med"},{"issue":"10","key":"1544_CR10","doi-asserted-by":"publisher","first-page":"23760","DOI":"10.3390\/ijms161023760","volume":"16","author":"EFLC Bail\u00e3o","year":"2015","unstructured":"Bail\u00e3o EFLC, Devilla IA, Concei\u00e7\u00e3o EC et al (2015) Bioactive compound found in brazilian cerrado fruits. Int J Mol Sci 16(10):23760\u201323783. https:\/\/doi.org\/10.3390\/ijms161023760","journal-title":"Int J Mol Sci"},{"key":"1544_CR11","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1007\/s11010-017-3110-1","volume":"438","author":"SMA Bastaki","year":"2018","unstructured":"Bastaki SMA, Padol IT, Amir N et al (2018) Effect of Aspirin and ibuprofen either alone or in combination on gastric mucosa and bleeding time and on serum prostaglandin E2 and thromboxane A2 levels in the anaesthetized rats in vivo. Mol Cell Biochem 438:25\u201334. https:\/\/doi.org\/10.1007\/s11010-017-3110-1","journal-title":"Mol Cell Biochem"},{"issue":"9","key":"1544_CR12","doi-asserted-by":"publisher","first-page":"12","DOI":"10.3390\/biom12091208","volume":"12","author":"ADSJ Batalha","year":"2022","unstructured":"Batalha ADSJ, Souza DCM, Ubiera RD et al (2022) Therapeutic potential of leaves from Fridericia chica (Bonpl) L G Lohmann: botanical aspects, phytochemical and biological, anti-inflammatory. Antioxidant Heal Action Biomol 12(9):12. https:\/\/doi.org\/10.3390\/biom12091208","journal-title":"Antioxidant Heal Action Biomol"},{"issue":"391","key":"1544_CR13","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12906-015-0923-x","volume":"15","author":"LM Batista","year":"2015","unstructured":"Batista LM, Lima GRM, Almeida ABA et al (2015) Ulcer healing and mechanism(s) of action involved in the gastroprotective activity of fractions obtained from Syngonanthus arthrotrichus and Syngonanthus bisulcatus. BMC Complement Altern Med 15(391):1\u20139. https:\/\/doi.org\/10.1186\/s12906-015-0923-x","journal-title":"BMC Complement Altern Med"},{"key":"1544_CR14","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2019.112473","volume":"250","author":"RC Benvenutti","year":"2020","unstructured":"Benvenutti RC, Vecchia CAD, Locateli G et al (2020) Gastroprotective activity of hydroalcoholic extract of the leaves of Urera baccifera in rodents. J Ethnopharmacol 250:112473. https:\/\/doi.org\/10.1016\/j.jep.2019.112473","journal-title":"J Ethnopharmacol"},{"issue":"13","key":"1544_CR15","doi-asserted-by":"publisher","first-page":"6957","DOI":"10.1021\/jf2003267","volume":"59","author":"AMSS Beserra","year":"2011","unstructured":"Beserra AMSS, Calegari PI, Souza MC et al (2011) Gastroprotective and ulcer-healing mechanisms of Ellagic acid in experimental rats. J Agric Food Chem 59(13):6957\u20136965. https:\/\/doi.org\/10.1021\/jf2003267","journal-title":"J Agric Food Chem"},{"issue":"9","key":"1544_CR16","doi-asserted-by":"publisher","first-page":"3257","DOI":"10.1021\/ct300400x","volume":"8","author":"RB Best","year":"2012","unstructured":"Best RB, Zhu X, Shim J (2012) Optimization of the additive CHARMM all-atom protein force field targeting improved sampling of the backbone, and side-chain and dihedral angles. J Chem Theory Comput 8(9):3257\u20133273. https:\/\/doi.org\/10.1021\/ct300400x","journal-title":"J Chem Theory Comput"},{"issue":"2","key":"1544_CR17","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1152\/physrev.00040.2012","volume":"92","author":"A Bhattacharyya","year":"2014","unstructured":"Bhattacharyya A, Chattopadhyay R, Mitra S et al (2014) Oxidative stress: as essential factor in the pathogenesis of gastrointestinal mucosal diseases. Physiol Rev 92(2):329\u2013254. https:\/\/doi.org\/10.1152\/physrev.00040.2012","journal-title":"Physiol Rev"},{"issue":"D1","key":"1544_CR18","doi-asserted-by":"publisher","first-page":"D313","DOI":"10.1093\/nar\/gkw1132","volume":"45","author":"S Bienert","year":"2017","unstructured":"Bienert S, Waterhouse A, Beer TAP et al (2017) The SWISS-MODEL repository-new features and functionality. Nucleic Acids Res 45(D1):D313\u2013D319. https:\/\/doi.org\/10.1093\/nar\/gkw1132","journal-title":"Nucleic Acids Res"},{"key":"1544_CR19","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1016\/j.jep.2015.07.025","volume":"173","author":"IGC Bieski","year":"2015","unstructured":"Bieski IGC, Leonti M, Arnason JT (2015) Ethnobotanical study of medicinal plants by population of Valley of Juruena Region, Legal Amazon, Mato Grosso, Brazil. J Ethnopharmacol 173:383\u2013423. https:\/\/doi.org\/10.1016\/j.jep.2015.07.025","journal-title":"J Ethnopharmacol"},{"key":"1544_CR20","unstructured":"Brasil (2014) MS elabora Rela\u00e7\u00e3o Nacional de Plantas Medicinais de Interesse ao SUS;. https:\/\/bvsms.saude.gov.br\/bvs\/sus\/pdf\/marco\/ms_relacao_plantas_medicinais_sus_0603.pdf. Accessed 05 December 2023"},{"key":"1544_CR21","unstructured":"CGenFF Interface at Paramchem.org (2018) https:\/\/cgenff.silcsbio.com\/. Accessed 1 Jan 2024"},{"key":"1544_CR22","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1016\/0016-5085(78)90356-6","volume":"74","author":"TK Chaudhury","year":"1978","unstructured":"Chaudhury TK, Jacobson ED (1978) Prostaglandin cytoprotection of gastric mucosa. Gastroenterol 74:58\u201363. https:\/\/doi.org\/10.1016\/0016-5085(78)90356-6","journal-title":"Gastroenterol"},{"issue":"3","key":"1544_CR23","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1093\/gastro\/gov004","volume":"3","author":"S Dacha","year":"2015","unstructured":"Dacha S, Razvi M, Massaad J et al (2015) Hypergastrinemia Gastroenterol Rep 3(3):201\u2013208. https:\/\/doi.org\/10.1093\/gastro\/gov004","journal-title":"Hypergastrinemia Gastroenterol Rep"},{"key":"1544_CR24","doi-asserted-by":"publisher","first-page":"10089","DOI":"10.1063\/1.464397","volume":"98","author":"T Darden","year":"1993","unstructured":"Darden T, York D, Pedersen L (1993) Particle mesh Ewald: An N\u22c5log(N) method for ewald sums in large systems. J Chem Phys 98:10089\u201310092. https:\/\/doi.org\/10.1063\/1.464397","journal-title":"J Chem Phys"},{"issue":"1","key":"1544_CR25","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1016\/s0891-5849(96)00547-3","volume":"23","author":"D Das","year":"1997","unstructured":"Das D, Bandyopadhyay D, Bhattacharjee M et al (1997) Hydroxyl radical is the major causative factor in stress-induced gastric ulceration. Free Radic Biol Med 23(1):8\u201318. https:\/\/doi.org\/10.1016\/s0891-5849(96)00547-3","journal-title":"Free Radic Biol Med"},{"issue":"93","key":"1544_CR26","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3389\/fchem.2020.00093","volume":"8","author":"LR De Souza Neto","year":"2020","unstructured":"De Souza Neto LR, Moreira-Filho JT, Neves BJ et al (2020) In silico strategies to support fragmente-to-lead optimization in drug discovery. Front Chem 8(93):1\u201318. https:\/\/doi.org\/10.3389\/fchem.2020.00093","journal-title":"Front Chem"},{"issue":"1","key":"1544_CR27","doi-asserted-by":"publisher","first-page":"234","DOI":"10.1016\/j.jep.2011.11.007","volume":"139","author":"FM De-Faria","year":"2012","unstructured":"De-Faria FM, Almeida ACA, Luiz-Ferreira A et al (2012) Mechanisms of action underlying the gastric antiulcer activity of the Rhizophora mangle L. J Ethnopharmacol 139(1):234\u2013243. https:\/\/doi.org\/10.1016\/j.jep.2011.11.007","journal-title":"J Ethnopharmacol"},{"key":"1544_CR28","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2020.173579","volume":"887","author":"P Dejban","year":"2020","unstructured":"Dejban P, Eslami F, Rahimi N et al (2020) Involvement of nitric oxide pathway in the anti-inflammatory effect of modafinil on indomethacin-, stress-, and ethanol -induced gastric mucosal injury in rat. Eur J Pharmacol 887:173579. https:\/\/doi.org\/10.1016\/j.ejphar.2020.173579","journal-title":"Eur J Pharmacol"},{"issue":"2","key":"1544_CR29","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1002\/pca.632","volume":"13","author":"B Devia","year":"2002","unstructured":"Devia B, Llabres G, Wouters J et al (2002) New 3-deoxyanthocyanidins from leaves of Arrabidaea chica. Phytochem Anal 13(2):114\u2013120. https:\/\/doi.org\/10.1002\/pca.632","journal-title":"Phytochem Anal"},{"issue":"3","key":"1544_CR30","doi-asserted-by":"publisher","first-page":"33","DOI":"10.3390\/biom6030033","volume":"6","author":"HO Duarte","year":"2016","unstructured":"Duarte HO, Freitas D, Gomes C et al (2016) Mucin-Type O-Glycosylation in gastric carcinogenesis. Biomolecules 6(3):33. https:\/\/doi.org\/10.3390\/biom6030033","journal-title":"Biomolecules"},{"issue":"5","key":"1544_CR31","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1097\/SGA.0000000000000478","volume":"42","author":"JJ Dunlap","year":"2019","unstructured":"Dunlap JJ, Patterson S (2019) Peptic ulcer disease. Gastroenterol Nurs 42(5):451\u2013454. https:\/\/doi.org\/10.1097\/SGA.0000000000000478","journal-title":"Gastroenterol Nurs"},{"key":"1544_CR32","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jcim.1c00203","author":"J Eberhardt","year":"2021","unstructured":"Eberhardt J, Santos-Martins D, Tillack AF (2021) AutoDock vina 1.2.0: new docking methods, expanded force field, and python bindings. J Chem Inf Model. https:\/\/doi.org\/10.1021\/acs.jcim.1c00203","journal-title":"J Chem Inf Model"},{"key":"1544_CR33","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1016\/j.jep.2005.04.020","volume":"101","author":"I Esteves","year":"2005","unstructured":"Esteves I, Souza IR, Rodrigues M et al (2005) Gastric antiulcer and anti-inflammatory activities of the essential oil from Casearia sylvestris Sw. J Ethnopharmacol 101:191\u2013196. https:\/\/doi.org\/10.1016\/j.jep.2005.04.020","journal-title":"J Ethnopharmacol"},{"issue":"8","key":"1544_CR34","doi-asserted-by":"publisher","first-page":"1175","DOI":"10.1136\/gut.2007.121533","volume":"56","author":"M Feldman","year":"2007","unstructured":"Feldman M, Friedman LS, Brandt LJ (2007) Sleisenger and Fordtran\u2019s Gastrointestinal and Liver Disease. Gut 56(8):1175. https:\/\/doi.org\/10.1136\/gut.2007.121533","journal-title":"Gut"},{"key":"1544_CR35","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2023.116338","author":"FF Figueiredo","year":"2023","unstructured":"Figueiredo FF, Damazo AS, Arunachalam K et al (2023) Evaluation of the gastroprotective and ulcer healing properties by Fridericia chica (Bonpl) L.G. Lohmann hydroethanolic extract of leaves. J Ethnopharmacol. https:\/\/doi.org\/10.1016\/j.jep.2023.116338","journal-title":"J Ethnopharmacol"},{"key":"1544_CR36","doi-asserted-by":"publisher","first-page":"258","DOI":"10.1016\/j.jprot.2018.09.007","volume":"192","author":"F Finamore","year":"2019","unstructured":"Finamore F, Reny JL, Malacarne S et al (2019) A high glucose leve lis associated with decreased aspirin-mediated acetylation of platelet cycloocygenase (COX)-1 at serine 529: a pilot study. J Proteom 192:258\u2013266. https:\/\/doi.org\/10.1016\/j.jprot.2018.09.007","journal-title":"J Proteom"},{"issue":"6","key":"1544_CR37","doi-asserted-by":"publisher","first-page":"557","DOI":"10.1590\/1516-3180.2018.0019220318","volume":"136","author":"M Forgerini","year":"2018","unstructured":"Forgerini M, Mieli S, Mastroianni PC (2018) Safety assessment of omeprazole use: a review. S\u00e3o Paulo Med J 136(6):557\u2013570. https:\/\/doi.org\/10.1590\/1516-3180.2018.0019220318","journal-title":"S\u00e3o Paulo Med J"},{"issue":"4","key":"1544_CR38","doi-asserted-by":"publisher","first-page":"706","DOI":"10.1053\/j.gastro.2017.01.031","volume":"152","author":"DE Freedberg","year":"2017","unstructured":"Freedberg DE, Kim LS, Yang YX (2017) The risks and benefits of long-term use of proton pump inhibitors: expert review and best practice advice from the American Gastroenterological Association. Gastroenterol 152(4):706\u2013715. https:\/\/doi.org\/10.1053\/j.gastro.2017.01.031","journal-title":"Gastroenterol"},{"issue":"10","key":"1544_CR39","doi-asserted-by":"publisher","first-page":"1031","DOI":"10.1080\/17512433.2018.1516143","volume":"11","author":"G Garc\u00eda-Rayado","year":"2018","unstructured":"Garc\u00eda-Rayado G, Navarro M, Lanas A (2018) NSAID induced gastrointestinal damage and designing GI-sparing NSAIDs. Expert Rev Clin Pharmacol 11(10):1031\u20131043. https:\/\/doi.org\/10.1080\/17512433.2018.1516143","journal-title":"Expert Rev Clin Pharmacol"},{"issue":"11","key":"1544_CR40","doi-asserted-by":"publisher","first-page":"700","DOI":"10.1038\/nchembio.115","volume":"4","author":"ED Garcin","year":"2008","unstructured":"Garcin ED, Arvai AS, Rosenfeld RJ et al (2008) Anchored plasticity opens doors for selective inhibitor design in nitric oxide synthase. Nat Chem Biol 4(11):700\u2013707. https:\/\/doi.org\/10.1038\/nchembio.115","journal-title":"Nat Chem Biol"},{"issue":"2","key":"1544_CR41","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1002\/biof.1699","volume":"47","author":"F Gendrisch","year":"2021","unstructured":"Gendrisch F, Esser PR, Schempp CM et al (2021) Luteolin as a modulator of skin aging and inflammation. BioFactors 47(2):170\u2013180. https:\/\/doi.org\/10.1002\/biof.1699","journal-title":"BioFactors"},{"key":"1544_CR42","doi-asserted-by":"publisher","DOI":"10.1021\/ct200723y","author":"K Hart","year":"2012","unstructured":"Hart K, Foloppe N, Baker CM et al (2012) Optimization of the CHARMM additive force field for DNA: Improved treatment of the BI\/BII conformational equilibrium. J Chem Theory Comput. https:\/\/doi.org\/10.1021\/ct200723y","journal-title":"J Chem Theory Comput"},{"issue":"3","key":"1544_CR43","doi-asserted-by":"publisher","first-page":"3203","DOI":"10.3390\/ijms13033203","volume":"13","author":"NZT Jesus","year":"2012","unstructured":"Jesus NZT, Falc\u00e3o HS, Gomes IF et al (2012) Tannins, peptic ulcers and related mechanisms. Int J Mol Sci 13(3):3203\u20133228. https:\/\/doi.org\/10.3390\/ijms13033203","journal-title":"Int J Mol Sci"},{"issue":"3","key":"1544_CR44","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1016\/j.jep.2008.04.024","volume":"118","author":"MP Jorge","year":"2008","unstructured":"Jorge MP, Madjarof C, Ruiz ALTG et al (2008) Evaluation of wound healing properties of Arrabidaea chica Verlot extract. J Ethnopharmacol 118(3):361\u2013366. https:\/\/doi.org\/10.1016\/j.jep.2008.04.024","journal-title":"J Ethnopharmacol"},{"issue":"1","key":"1544_CR45","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1002\/pro.3280","volume":"27","author":"E Jurrus","year":"2018","unstructured":"Jurrus E, Engel D, Star K et al (2018) Improvements to the APBS biomolecular solvation software suite. Protein Sci 27(1):112\u2013128. https:\/\/doi.org\/10.1002\/pro.3280","journal-title":"Protein Sci"},{"issue":"4","key":"1544_CR46","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1007\/s00535-021-01769-0","volume":"56","author":"T Kamada","year":"2021","unstructured":"Kamada T, Satoh K, Itoh T et al (2021) Evidence-based clinical practice guidelines for peptic ulcer disease 2020. J Gastroenterol 56(4):303\u2013322. https:\/\/doi.org\/10.1007\/s00535-021-01769-0","journal-title":"J Gastroenterol"},{"issue":"3","key":"1544_CR47","doi-asserted-by":"publisher","first-page":"64","DOI":"10.3390\/medicina55030064","volume":"55","author":"NS Karampour","year":"2019","unstructured":"Karampour NS, Arzi A, Rezaie A et al (2019) Gastroprotective effect of zingerone on ethanol-induced gastric ulcers in rats. Medicina 55(3):64. https:\/\/doi.org\/10.3390\/medicina55030064","journal-title":"Medicina"},{"issue":"4","key":"1544_CR48","doi-asserted-by":"publisher","first-page":"447","DOI":"10.1016\/j.amjmed.2018.12.009","volume":"132","author":"RT Kavitt","year":"2019","unstructured":"Kavitt RT, Lipowska AM, Anyane-Yeboa A et al (2019) Diagnosis and treatment of peptic ulcer disease. Am J Med 132(4):447\u2013456. https:\/\/doi.org\/10.1016\/j.amjmed.2018.12.009","journal-title":"Am J Med"},{"issue":"10","key":"1544_CR49","doi-asserted-by":"publisher","first-page":"436","DOI":"10.1016\/S1359-6446(97)01099","volume":"2","author":"T Kennedy","year":"1997","unstructured":"Kennedy T (1997) Managing the drug discovery\/development interface. Drug Discov Today 2(10):436\u2013444. https:\/\/doi.org\/10.1016\/S1359-6446(97)01099","journal-title":"Drug Discov Today"},{"key":"1544_CR50","volume-title":"Berne & Levy","author":"BM Koeppen","year":"2009","unstructured":"Koeppen BM, Stanton BA (2009) Berne & Levy. Fisiologia, Elsevier, Rio de Janeiro"},{"issue":"2","key":"1544_CR51","doi-asserted-by":"publisher","first-page":"179","DOI":"10.3390\/jcm8020179","volume":"8","author":"L Kuna","year":"2019","unstructured":"Kuna L, Jakab J, Smolic R et al (2019) Peptic ulcer disease: a brief review of conventional therapy and herbal treatment options. J Clin Med 8(2):179. https:\/\/doi.org\/10.3390\/jcm8020179","journal-title":"J Clin Med"},{"issue":"2","key":"1544_CR52","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1016\/j.jaim.2016.06.003","volume":"7","author":"L Lawrence","year":"2016","unstructured":"Lawrence L, Menon S, Vincent S et al (2016) Radical scavenging and gastroprotective activity of methanolic extract of Gmelina arborea stem bark. J-AIM 7(2):78\u201382. https:\/\/doi.org\/10.1016\/j.jaim.2016.06.003","journal-title":"J-AIM"},{"issue":"1\u20132","key":"1544_CR53","doi-asserted-by":"publisher","first-page":"214","DOI":"10.1016\/j.mrfmmm.2005.03.027","volume":"579","author":"JS Lee","year":"2005","unstructured":"Lee JS, Oh TY, Kim YK et al (2005) Protective effects of green tea polyphenol extracts against ethanol-induced gastric mucosal damages in rats: stress-responsive transcription factors and MAP kinases as potential targets. Mutat Res 579(1\u20132):214\u2013224. https:\/\/doi.org\/10.1016\/j.mrfmmm.2005.03.027","journal-title":"Mutat Res"},{"issue":"3","key":"1544_CR54","doi-asserted-by":"publisher","first-page":"246","DOI":"10.1093\/abbs\/gmy002","volume":"50","author":"Q Li","year":"2018","unstructured":"Li Q, Hu X, Xuan Y et al (2018) Kaempferol protects ethanol-induced gastric ulcers in mice via pro-inflammatory cytokines and NO. ABBS 50(3):246\u2013253. https:\/\/doi.org\/10.1093\/abbs\/gmy002","journal-title":"ABBS"},{"issue":"21","key":"1544_CR55","doi-asserted-by":"publisher","first-page":"11985","DOI":"10.3390\/ijms222111985","volume":"22","author":"WS Li","year":"2021","unstructured":"Li WS, Lin SC, Chu CH et al (2021) The gastroprotective effect of naringenin against ethanol-induced gastric ulcers in mice through inhibiting oxidative and inflammatory responses. Int J Mol Sci 22(21):11985. https:\/\/doi.org\/10.3390\/ijms222111985","journal-title":"Int J Mol Sci"},{"key":"1544_CR56","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1515\/jbcpp-2013-0165","volume":"26","author":"VB Liju","year":"2015","unstructured":"Liju VB, Jeena K, Kuttan R et al (2015) Gastroprotective activity of essential oils from turmeric and ginger. J Basic Clin Physiol Pharmacol 26:95\u2013103. https:\/\/doi.org\/10.1515\/jbcpp-2013-0165","journal-title":"J Basic Clin Physiol Pharmacol"},{"issue":"1\u20133","key":"1544_CR57","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/S0169-409X(96)00423-1","volume":"23","author":"CA Lipinski","year":"1997","unstructured":"Lipinski CA, Lombardo F, Dominy BW et al (1997) Experimental and computacional approaches to estimate solubility and permeability in drug discovery and development settings. Adv Drug Deliv Rev 23(1\u20133):3\u201325. https:\/\/doi.org\/10.1016\/S0169-409X(96)00423-1","journal-title":"Adv Drug Deliv Rev"},{"key":"1544_CR58","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1016\/j.freeradbiomed.2021.03.037","volume":"168","author":"Z Liu","year":"2021","unstructured":"Liu Z, Yao X, Sun B et al (2021) Pretreatment with kaempferol attenuates microglia-mediate neuroinflammation by inhibiting MAPKs-NF-\u03baB signaling pathway and pyroptosis after secondary spinal cord injury. Free Radic Biol Med 168:142\u2013154. https:\/\/doi.org\/10.1016\/j.freeradbiomed.2021.03.037","journal-title":"Free Radic Biol Med"},{"key":"1544_CR59","volume-title":"Plantas Medicinais do Brasil: nativas e ex\u00f3ticas","author":"H Lorenzi","year":"2008","unstructured":"Lorenzi H, Matos FJA (2008) Plantas Medicinais do Brasil: nativas e ex\u00f3ticas, 2nd edn. Instituto Plantarum, USA, Nova Odessa, SP","edition":"2"},{"key":"1544_CR60","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2013.09.008","author":"L Mafioleti","year":"2013","unstructured":"Mafioleti L, Silva Junior IF, Colodel EM et al (2013) Evaluation of the toxicity and antimicrobial activity of hydroethanolic extract of Arrabidaea chica (Humb & Bonpl) B. Verl J Ethnopharmacol. https:\/\/doi.org\/10.1016\/j.jep.2013.09.008","journal-title":"Verl J Ethnopharmacol"},{"issue":"5","key":"1544_CR61","doi-asserted-by":"publisher","first-page":"9099","DOI":"10.3390\/molecules20059099","volume":"20","author":"M Magierowski","year":"2015","unstructured":"Magierowski M, Magierowska K, Kwiecien S et al (2015) Gaseous mediators nitric oxide and hydrogen sulfide in the mechanism of gastrointestinal integrity, protection and ulcer healing. Molecules 20(5):9099\u20139123. https:\/\/doi.org\/10.3390\/molecules20059099","journal-title":"Molecules"},{"issue":"3","key":"1544_CR62","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1111\/j.1432-1033.1974.tb03714.x","volume":"47","author":"S Marklund","year":"1974","unstructured":"Marklund S, Marklund G (1974) Involvement of the superoxide anion radical in the atoxidation of pyrogallol and a convenient assay for superoxide dismutase. Eur J Biochem 47(3):469\u2013474. https:\/\/doi.org\/10.1111\/j.1432-1033.1974.tb03714.x","journal-title":"Eur J Biochem"},{"issue":"2","key":"1544_CR63","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1016\/s0024-3205(99)00241-6","volume":"65","author":"H Matsuda","year":"1999","unstructured":"Matsuda H, Li Y, Yoshikawa M (1999) Roles of capsaicin-sensitive sensory nerves, endogenous nitric oxide, sulfhydrys, and prostaglandins in gastroprotection by momordin Ic, an oleanolic acid oligoglycoside, on ethanol-induced gastric mucosal lesions in rats. Life Sci 65(2):27\u201332. https:\/\/doi.org\/10.1016\/s0024-3205(99)00241-6","journal-title":"Life Sci"},{"issue":"12","key":"1544_CR64","doi-asserted-by":"publisher","first-page":"1745","DOI":"10.1016\/s0891-5849(00)232-x","volume":"28","author":"EA Meagher","year":"2000","unstructured":"Meagher EA, Fitzgerald GA (2000) Indices of lipid peroxidation in vivo: Strengths and limitations. Free Radic Biol Med 28(12):1745\u20131750. https:\/\/doi.org\/10.1016\/s0891-5849(00)232-x","journal-title":"Free Radic Biol Med"},{"key":"1544_CR65","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1007\/978-1-61779-080-5_20","volume":"731","author":"JV Meerloo","year":"2011","unstructured":"Meerloo JV, Kaspers GJL, Cloos J (2011) Cell sensitivity assays: the MTT assay. Methods Mol Biol 731:237\u2013245. https:\/\/doi.org\/10.1007\/978-1-61779-080-5_20","journal-title":"Methods Mol Biol"},{"key":"1544_CR66","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1016\/j.jep.2015.02.011","volume":"165","author":"AFRM Michel","year":"2015","unstructured":"Michel AFRM, Melo MM, Campos PP et al (2015) Evaluation of anti-inflammatory, antiangiogenic and antiproliferative activities of Arrabidaea chica crude extracts. J Ethnopharmacol 165:29\u201338. https:\/\/doi.org\/10.1016\/j.jep.2015.02.011","journal-title":"J Ethnopharmacol"},{"issue":"3","key":"1544_CR67","doi-asserted-by":"publisher","first-page":"175","DOI":"10.2174\/1574884714666190312143846","volume":"14","author":"AP Mishra","year":"2019","unstructured":"Mishra AP, Bajpai A, Chandra S (2019) A comprehensive review on the screening models for the pharmacological assessment of antiulcer drugs. Curr Clin Pharmacol 14(3):175\u2013196. https:\/\/doi.org\/10.2174\/1574884714666190312143846","journal-title":"Curr Clin Pharmacol"},{"issue":"15","key":"1544_CR68","doi-asserted-by":"publisher","first-page":"3547","DOI":"10.3390\/molecules25153547","volume":"25","author":"CJ Moragas-Tellis","year":"2020","unstructured":"Moragas-Tellis CJ, Almeida-Souza F, Chagas MSS et al (2020) The influence of anthocyanidin profile on antileishmanial activity of Arrabidaea chica morphotypes. Molecules 25(15):3547. https:\/\/doi.org\/10.3390\/molecules25153547","journal-title":"Molecules"},{"issue":"4","key":"1544_CR69","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1254\/jjp.57.495","volume":"57","author":"Y Morimoto","year":"1991","unstructured":"Morimoto Y, Shimohara K, Oshima S et al (1991) Effects of the new anti-ulcer agent KB-5492 on experimental gastric mucosal lesions and gastric mucosal defensive factors, as compared to those of teprenone and cimetidine. Jpn J Pharmacol 57(4):495\u2013505. https:\/\/doi.org\/10.1254\/jjp.57.495","journal-title":"Jpn J Pharmacol"},{"key":"1544_CR70","first-page":"628","volume":"32","author":"RW Mowry","year":"1956","unstructured":"Mowry RW, Winkler CH (1956) The coloration of acidic carbohydrates of bacteria and fungi in tissue sections, with special reference to capsules of cryptococcus neoformans, pneumococci, and staphylococci. Am J Path 32:628\u2013629","journal-title":"Am J Path"},{"key":"1544_CR71","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1055\/s-2006-960103","volume":"57","author":"S Murakami","year":"1991","unstructured":"Murakami S, Isobe Y, Kijima H et al (1991) Inhibition of gastric H+, K(+)-ATPase and acid secretion by ellagic acid. Planta Med 57:305\u2013308. https:\/\/doi.org\/10.1055\/s-2006-960103","journal-title":"Planta Med"},{"issue":"14","key":"1544_CR72","doi-asserted-by":"publisher","first-page":"2053","DOI":"10.3748\/wjg.v13.i14.2053","volume":"13","author":"L Nagy","year":"2007","unstructured":"Nagy L, Nagata M, Szabo S (2007) Protein and non-protein sulfhydryls and disulfides in gastric mucosa and liver after gastroxic chemicals and sucralfate: possible new targets of pharmacologic agents. World J Gastroenterol 13(14):2053\u20132060. https:\/\/doi.org\/10.3748\/wjg.v13.i14.2053","journal-title":"World J Gastroenterol"},{"key":"1544_CR73","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jnatprod.9b01285","author":"DJ Newman","year":"2020","unstructured":"Newman DJ, Cragg GM (2020) Natural Products as sources of new drugs over the nearly four decades from 01\/1981 to 09\/2019. J Nat Prod. https:\/\/doi.org\/10.1021\/acs.jnatprod.9b01285","journal-title":"J Nat Prod"},{"issue":"3","key":"1544_CR74","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1016\/S0378-8741(00)00261-0","volume":"72","author":"PA Nwafor","year":"2000","unstructured":"Nwafor PA, Okwuasaba FK, Binda LG (2000) Antidiarrheal and antiulcerogenic effects of methanolic extract of Asparagus pubescens root in rats. J Ethnopharmacol 72(3):421\u2013427. https:\/\/doi.org\/10.1016\/S0378-8741(00)00261-0","journal-title":"J Ethnopharmacol"},{"issue":"2","key":"1544_CR75","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1016\/0003-2697(79)90738-3","volume":"95","author":"H Ohkawa","year":"1979","unstructured":"Ohkawa H, Ohishi N, Yagi K (1979) Assay for lipid peroxides in animal tissue by thiobarbituric acid reaction. Anal Biochem 95(2):351\u2013358. https:\/\/doi.org\/10.1016\/0003-2697(79)90738-3","journal-title":"Anal Biochem"},{"key":"1544_CR76","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2022.115660","volume":"298","author":"BMM Oliveira","year":"2022","unstructured":"Oliveira BMM, Serpa PZ, Zanatta MEC (2022) Gastroprotective and gastric healing effects of the aqueous extract of Casearia sylvestris in rodents: ultrasound, histological and biochemical analyzes. J Ethnopharmacol 298:115660. https:\/\/doi.org\/10.1016\/j.jep.2022.115660","journal-title":"J Ethnopharmacol"},{"key":"1544_CR77","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.3000410","author":"N Percie du Sert","year":"2020","unstructured":"Percie du Sert N, Hurst V, Ahluwalia A et al (2020) The ARRIVE guidelines 2.0: Updated guidelines for reporting animal research. PLoS Biol. https:\/\/doi.org\/10.1371\/journal.pbio.3000410","journal-title":"PLoS Biol"},{"key":"1544_CR78","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1016\/j.ijpddr.2019.10.004","volume":"11","author":"Y P\u00e9rez-Pertejo","year":"2019","unstructured":"P\u00e9rez-Pertejo Y, Escudero-Mart\u00ednez JM, Reguera RM et al (2019) Antileishmanial activity of terpenylquinones on Leishmania infantum and their effects on Leishmania topoisomerase IB. Int J Parasitol Drugs Drug Resist 11:70\u201379. https:\/\/doi.org\/10.1016\/j.ijpddr.2019.10.004","journal-title":"Int J Parasitol Drugs Drug Resist"},{"key":"1544_CR79","first-page":"109","volume":"65","author":"BM Peskar","year":"1980","unstructured":"Peskar BM (1980) Effect of carbenoxolone on prostaglandin synthesizing and metabolizing enzymes and correlation with gastric mucosal carbenoxolone concentrations. Scand J Gastroenterol 65:109\u2013114","journal-title":"Scand J Gastroenterol"},{"issue":"2","key":"1544_CR80","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1159\/000481399","volume":"36","author":"KU Petersen","year":"2018","unstructured":"Petersen KU (2018) Pepsin and its importance for functional dyspepsia: relic, regulator or remedy? Dig Dis 36(2):98\u2013105. https:\/\/doi.org\/10.1159\/000481399","journal-title":"Dig Dis"},{"issue":"4","key":"1544_CR81","doi-asserted-by":"publisher","DOI":"10.1063\/5.0014475","volume":"153","author":"JC Phillips","year":"2020","unstructured":"Phillips JC, Hardy DJ, Maia JDC et al (2020) Scalable molecular dynamics on CPU and GPU architectures with NAMD. J Chem Phys 153(4):044130. https:\/\/doi.org\/10.1063\/5.0014475","journal-title":"J Chem Phys"},{"issue":"7","key":"1544_CR82","doi-asserted-by":"publisher","first-page":"2466","DOI":"10.3390\/molecules14072466","volume":"14","author":"A Plazoni\u0107","year":"2009","unstructured":"Plazoni\u0107 A, Buncar F, Males Z et al (2009) Using high-performance liquid chromatography with diode array detection and electrospray ionization mass spectrometry. Molecules 14(7):2466\u20132490. https:\/\/doi.org\/10.3390\/molecules14072466","journal-title":"Molecules"},{"key":"1544_CR83","doi-asserted-by":"publisher","DOI":"10.1590\/s0102-865020190100000001","author":"KBF Rocha","year":"2019","unstructured":"Rocha KBF, Oliveira CN, Azevedo IM et al (2019) Effect of Arrabidaea chica extract against chemically induced breast cancer in animal model. Acta Cir Bras. https:\/\/doi.org\/10.1590\/s0102-865020190100000001","journal-title":"Acta Cir Bras"},{"issue":"3","key":"1544_CR84","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1016\/j.cnur.2013.05.001","volume":"48","author":"A Rundio Junior","year":"2013","unstructured":"Rundio Junior A (2013) Understanding alcoholism. Nurs Clin North Am 48(3):385\u2013390. https:\/\/doi.org\/10.1016\/j.cnur.2013.05.001","journal-title":"Nurs Clin North Am"},{"key":"1544_CR85","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1016\/j.jim.2017.07.003","volume":"449","author":"M Russell","year":"2017","unstructured":"Russell M, Prokoph N, Henderson N et al (2017) Determining myeloperoxidase activity and protein concentration in a single assay: utility in biomarker and therapeutic studies. J Immunol Methods 449:76\u201379. https:\/\/doi.org\/10.1016\/j.jim.2017.07.003","journal-title":"J Immunol Methods"},{"issue":"3","key":"1544_CR86","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1016\/0021-9991(77)90098-5","volume":"23","author":"JP Ryckaert","year":"1977","unstructured":"Ryckaert JP, Ciccotti G, Berendsen HJC (1977) Numerical integration of the cartesian equations of motion of a system with constraints: molecular dynamics of n-alkanes. J Comput Phys 23(3):327\u2013341. https:\/\/doi.org\/10.1016\/0021-9991(77)90098-5","journal-title":"J Comput Phys"},{"issue":"1","key":"1544_CR87","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1097\/MCG.0000000000000432","volume":"50","author":"JM Scheiman","year":"2016","unstructured":"Scheiman JM (2016) NSAID-induced gastrointestinal injury: a focused update for clinicians. J Clin Gastroenterol 50(1):5\u201310. https:\/\/doi.org\/10.1097\/MCG.0000000000000432","journal-title":"J Clin Gastroenterol"},{"issue":"1","key":"1544_CR88","doi-asserted-by":"publisher","first-page":"192","DOI":"10.1016\/0003-2697(68)90092-4","volume":"25","author":"J Sedlak","year":"1968","unstructured":"Sedlak J, Lindsay R, H, (1968) Estimation of total protein-bound and nonprotein sulfhydril groups in tissues with Ellman\u2019s reagent. Anal Biochem 25(1):192\u2013205. https:\/\/doi.org\/10.1016\/0003-2697(68)90092-4","journal-title":"Anal Biochem"},{"key":"1544_CR89","doi-asserted-by":"publisher","DOI":"10.1016\/j.compbiomed.2021.104851","volume":"137","author":"B Shaker","year":"2021","unstructured":"Shaker B, Ahmad S, Lee J et al (2021) In silico methods and tools for drug discovery. Comput Biol Med 137:104851. https:\/\/doi.org\/10.1016\/j.compbiomed.2021.104851","journal-title":"Comput Biol Med"},{"key":"1544_CR90","first-page":"43","volume":"5","author":"H Shay","year":"1945","unstructured":"Shay H, Komarov SA, Fels SS (1945) A simple method for the uniform production of gastric ulceration in the rat. Gastroenterology 5:43\u201361","journal-title":"Gastroenterology"},{"issue":"33","key":"1544_CR91","doi-asserted-by":"publisher","first-page":"7069","DOI":"10.1021\/bi1003298","volume":"49","author":"RS Sidhu","year":"2010","unstructured":"Sidhu RS, Lee JY, Yuan C et al (2010) Comparison of cyclooxygenase-1 crystal structures: cross-talk between monomers comprising cyclooxygenase-1 homodimers. Biochemistry 49(33):7069\u20137079. https:\/\/doi.org\/10.1021\/bi1003298","journal-title":"Biochemistry"},{"key":"1544_CR92","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2021.111910","volume":"141","author":"JV Silva-Silva","year":"2021","unstructured":"Silva-Silva JV, Moragas-Tellis CJ, Chagas MSS (2021) Carajurin: a anthocyanidin from Arrabidaea chica as a potential biological marker of leishmanial activity. Biomed Pharmacother 141:111910. https:\/\/doi.org\/10.1016\/j.biopha.2021.111910","journal-title":"Biomed Pharmacother"},{"issue":"3","key":"1544_CR93","doi-asserted-by":"publisher","first-page":"331","DOI":"10.3390\/ph15030331","volume":"15","author":"JV Silva-Silva","year":"2022","unstructured":"Silva-Silva JV, Moragas-Tellis CJ, Chagas MSS et al (2022) Carajurin induces apoptosis in Leishmania amazonensis Promastigotes through reactive oxygen species production and mitochondrial dysfunction. Pharmaceuticals 15(3):331. https:\/\/doi.org\/10.3390\/ph15030331","journal-title":"Pharmaceuticals"},{"key":"1544_CR94","unstructured":"Soares VR, Rocha AD, Henriques BO (2016) Sabonete l\u00edquido com extrato etan\u00f3lico da esp\u00e9cie vegetal Arrabidaea chica. RACF, 1(1)."},{"key":"1544_CR95","doi-asserted-by":"publisher","DOI":"10.14309\/ajg.0000000000000517","author":"A Sonnenberg","year":"2020","unstructured":"Sonnenberg A, Turner KO, Genta RM (2020) Low prevalence of Helicobacter pylori-positive peptic ulcers in private outpatient endoscopy centers in the United States. Am J Gastroenterol. https:\/\/doi.org\/10.14309\/ajg.0000000000000517","journal-title":"Am J Gastroenterol"},{"issue":"6","key":"1544_CR96","doi-asserted-by":"publisher","first-page":"791","DOI":"10.1136\/gut.2002.012930","volume":"53","author":"MHLP Souza","year":"2004","unstructured":"Souza MHLP, Lemos HP, Oliveira RB et al (2004) Gastric damage and granulocyte infiltration induced by indomethacin in tumour necrosis factor receptor 1 (TNF-R1) or inducible nitric oxide synthase (iNOS) deficient mice. Gut 53(6):791\u2013796. https:\/\/doi.org\/10.1136\/gut.2002.012930","journal-title":"Gut"},{"issue":"1","key":"1544_CR97","doi-asserted-by":"publisher","first-page":"S5","DOI":"10.4103\/0974-8490.178649","volume":"8","author":"YH Syed","year":"2016","unstructured":"Syed YH, Khan M (2016) Chromatographic profiling of ellagic acid in woodfordia fruticosa flowers and their gastroprotective potential in ethanol-induced ulcers in rats. Pharmacognosy Res 8(1):S5\u2013S11. https:\/\/doi.org\/10.4103\/0974-8490.178649","journal-title":"Pharmacognosy Res"},{"key":"1544_CR98","doi-asserted-by":"publisher","DOI":"10.1080\/01480545.2019.1685537","author":"M Tahir","year":"2019","unstructured":"Tahir M, Rahman A, Khushtar M (2019) Gastroprotective effect of Hyssopus officinalis L. leaves via reduction of oxidative stress in indomethacin-induced gastric ulcer in experimental rats. Drug Chem Toxicol. https:\/\/doi.org\/10.1080\/01480545.2019.1685537","journal-title":"Drug Chem Toxicol"},{"issue":"8","key":"1544_CR99","doi-asserted-by":"publisher","first-page":"1964","DOI":"10.3390\/cells10081964","volume":"10","author":"AS Tarnawski","year":"2021","unstructured":"Tarnawski AS, Ahluwalia A (2021) The critical role of growth factors in gastric ulcer healing: the cellular and molecular mechanisms and potential clinical implications. Cells 10(8):1964. https:\/\/doi.org\/10.3390\/cells10081964","journal-title":"Cells"},{"issue":"2","key":"1544_CR100","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1002\/jcc.21334","volume":"31","author":"O Trott","year":"2010","unstructured":"Trott O, Olson AJ (2010) AutoDock Vina: improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading. J Comput Chem 31(2):455\u2013461. https:\/\/doi.org\/10.1002\/jcc.21334","journal-title":"J Comput Chem"},{"issue":"22","key":"1544_CR101","doi-asserted-by":"publisher","first-page":"3954","DOI":"10.3748\/wjg.v23.i22.3954","volume":"23","author":"E Utzeri","year":"2017","unstructured":"Utzeri E, Usai P (2017) Role of non-steroidal anti-inflammatory drugs on intestinal permeability and nonalcoholic fatty liver disease. World J Gastroenterol 23(22):3954\u20133963. https:\/\/doi.org\/10.3748\/wjg.v23.i22.3954","journal-title":"World J Gastroenterol"},{"key":"1544_CR102","doi-asserted-by":"publisher","first-page":"671","DOI":"10.1002\/jcc.21367","volume":"31","author":"K Vanommeslaeghe","year":"2010","unstructured":"Vanommeslaeghe K, Hatcher E, Acharya C et al (2010) CHARMM general force field: a force field for drug-like molecules compatible with the CHARMM all-atom additive biological force fields. J Comput Chem 31:671\u2013690. https:\/\/doi.org\/10.1002\/jcc.21367","journal-title":"J Comput Chem"},{"issue":"19","key":"1544_CR103","doi-asserted-by":"publisher","first-page":"4717","DOI":"10.3390\/ijms20194717","volume":"20","author":"CC Vasconcelos","year":"2019","unstructured":"Vasconcelos CC, Lopes AJO, Sousa ELF (2019) Effects of extract of Arrabidaea chica Verlot on an experimental model of osteoarthritis. Int J Mol Sci 20(19):4717. https:\/\/doi.org\/10.3390\/ijms20194717","journal-title":"Int J Mol Sci"},{"key":"1544_CR104","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/7413231","author":"CAD Vecchia","year":"2022","unstructured":"Vecchia CAD, Locateli G, Serpa PZ et al (2022) Sonchus oleraceus L promotes gastroprotection in rodents via antioxidant, anti-inflammatory, and antisecretory activities. Evid Based Complent Alternat Med. https:\/\/doi.org\/10.1155\/2022\/7413231","journal-title":"Evid Based Complent Alternat Med"},{"key":"1544_CR105","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1016\/j.biopha.2017.12.020","volume":"98","author":"L Venzon","year":"2018","unstructured":"Venzon L, Mariano LNB, Somensi LB et al (2018) Essential oil of Cymbopogon citratus (lemongrass) and geraniol, but not citral, promote gastric healing activity in mice. Biomed Pharmacother 98:118\u2013124. https:\/\/doi.org\/10.1016\/j.biopha.2017.12.020","journal-title":"Biomed Pharmacother"},{"issue":"1","key":"1544_CR106","doi-asserted-by":"publisher","DOI":"10.1016\/j.indcrop.2020.112412","volume":"152","author":"M Vidal-Guti\u00e9rrez","year":"2020","unstructured":"Vidal-Guti\u00e9rrez M, Robles-Zepeda RE, Vilegas W et al (2020) Phenolic composition and antioxidant activity of Bursera microphylla A. Gray Ind Crops Prod 152(1):112412. https:\/\/doi.org\/10.1016\/j.indcrop.2020.112412","journal-title":"Gray Ind Crops Prod"},{"key":"1544_CR107","doi-asserted-by":"publisher","first-page":"1547","DOI":"10.1152\/physrev.00004.2008","volume":"88","author":"JL Wallace","year":"2008","unstructured":"Wallace JL (2008) Prostaglandins, NSAIDs, and gastric mucosal protection: why doesn\u2019t the stomach digest itself? Physiol Rev 88:1547\u20131565. https:\/\/doi.org\/10.1152\/physrev.00004.2008","journal-title":"Physiol Rev"},{"issue":"2","key":"1544_CR108","doi-asserted-by":"publisher","first-page":"512","DOI":"10.1053\/gast.2000.9304","volume":"119","author":"JL Wallace","year":"2000","unstructured":"Wallace JL, Miller MJ (2000) Nitric oxide in mucosal defense: a little goes a long way. Gastroenterol 119(2):512\u2013520. https:\/\/doi.org\/10.1053\/gast.2000.9304","journal-title":"Gastroenterol"},{"issue":"43","key":"1544_CR109","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000027656","volume":"100","author":"H Wang","year":"2021","unstructured":"Wang H, Jiang H, Zhao J et al (2021) Acupuncture therapy for gastric ulcer: a protocol for systematic review and meta-analysis. Medicine 100(43):e27656. https:\/\/doi.org\/10.1097\/MD.0000000000027656","journal-title":"Medicine"},{"issue":"W1","key":"1544_CR110","doi-asserted-by":"publisher","first-page":"W296","DOI":"10.1093\/nar\/gky427","volume":"46","author":"A Waterhouse","year":"2018","unstructured":"Waterhouse A, Bertoni M, Bienert S et al (2018) SWISS-MODEL: homology modelling of protein structures and complexes. Nucleic Acids Res 46(W1):W296\u2013W303. https:\/\/doi.org\/10.1093\/nar\/gky427","journal-title":"Nucleic Acids Res"},{"key":"1544_CR111","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2021.111308","volume":"137","author":"Q Wu","year":"2021","unstructured":"Wu Q, Li W, Zhao J (2021) Apigenin ameliorates doxorubicin-induced renal injury via inhibition of oxidative stress and inflammation. Biomed Pharmacother 137:111308. https:\/\/doi.org\/10.1016\/j.biopha.2021.111308","journal-title":"Biomed Pharmacother"},{"issue":"19","key":"1544_CR112","doi-asserted-by":"publisher","first-page":"4251","DOI":"10.1021\/jf500180u","volume":"62","author":"J Xie","year":"2014","unstructured":"Xie J, Schaich KM (2014) Re-evaluation of the 2,2-diphenyl-1-picrylhydrazyl free radical (DPPH) assay for antioxidant activity. J Agric Food Chem 62(19):4251\u20134260. https:\/\/doi.org\/10.1021\/jf500180u","journal-title":"J Agric Food Chem"},{"issue":"5","key":"1544_CR113","doi-asserted-by":"publisher","first-page":"327","DOI":"10.2133\/dmpk.19.327","volume":"19","author":"F Yamashita","year":"2004","unstructured":"Yamashita F, Hashida M (2004) In silico approaches for predicting ADME properties of drugs. Drug Metab Pharmacokinet 19(5):327\u2013338. https:\/\/doi.org\/10.2133\/dmpk.19.327","journal-title":"Drug Metab Pharmacokinet"},{"key":"1544_CR114","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-84892-5","author":"MH Yim","year":"2021","unstructured":"Yim MH, Kim KH, Lee BJ (2021) The number of household members as a risk factor for peptic ulcer disease. Sci Rep. https:\/\/doi.org\/10.1038\/s41598-021-84892-5","journal-title":"Sci Rep"},{"issue":"3\u20134","key":"1544_CR115","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1007\/BF01967298","volume":"26","author":"L Young","year":"1989","unstructured":"Young L, M, De, Kheifets, J, B, Ballaron, S, J, Young, J, M (1989) Edema and cell infiltration in the phorbol ester-treated mouse ear are temporally separate and can be differentially modulated by pharmacologic agentes. Agents Actions 26(3\u20134):335\u2013341. https:\/\/doi.org\/10.1007\/BF01967298","journal-title":"Agents Actions"},{"key":"1544_CR116","doi-asserted-by":"publisher","first-page":"8987232","DOI":"10.1155\/2021\/8987232","volume":"1","author":"MEC Zanatta","year":"2021","unstructured":"Zanatta MEC, Miorando D, Stefller AM et al (2021) (2021) Gastroprotective effects of the aqueous extract from Taraxacum officinale in rats using ultrasound, histology, and biochemical analysis. Evid Based Complement Alternat Med 1:8987232. https:\/\/doi.org\/10.1155\/2021\/8987232","journal-title":"Evid Based Complement Alternat Med"},{"key":"1544_CR117","volume-title":"Citotoxicidade da Uncaria tomentosa, na forma de solu\u00e7\u00e3o, avaliada em culturas de c\u00e9lulas L929, por meio do teste MTT","author":"JO Zoccolotti","year":"2014","unstructured":"Zoccolotti JO, Pavarina AC, Barbugli PA et al (2014) Citotoxicidade da Uncaria tomentosa, na forma de solu\u00e7\u00e3o, avaliada em culturas de c\u00e9lulas L929, por meio do teste MTT. Universidade Estadual Paulista, Araraquara, XXVI Congresso de Inicia\u00e7\u00e3o Cient\u00edfica da Unesp"},{"issue":"8","key":"1544_CR118","doi-asserted-by":"publisher","first-page":"831","DOI":"10.1016\/s0031-9422(01)00038-3","volume":"56","author":"B Zorn","year":"2001","unstructured":"Zorn B, Garc\u00eda-Pi\u00f1eres AJ, Castro V et al (2001) 3-Desoxyanthocyanidins from Arrabidaea chica. Phytochemistry 56(8):831\u2013835. https:\/\/doi.org\/10.1016\/s0031-9422(01)00038-3","journal-title":"Phytochemistry"}],"container-title":["Inflammopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10787-024-01544-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10787-024-01544-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10787-024-01544-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,21]],"date-time":"2024-09-21T16:08:55Z","timestamp":1726934935000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10787-024-01544-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8,10]]},"references-count":118,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2024,10]]}},"alternative-id":["1544"],"URL":"https:\/\/doi.org\/10.1007\/s10787-024-01544-6","relation":{},"ISSN":["0925-4692","1568-5608"],"issn-type":[{"value":"0925-4692","type":"print"},{"value":"1568-5608","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,8,10]]},"assertion":[{"value":"22 May 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 July 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 August 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no conflicts of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflicts of interest"}}]}}