{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T10:18:34Z","timestamp":1792059514605,"version":"4.4.0"},"reference-count":119,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2024,8,21]],"date-time":"2024-08-21T00:00:00Z","timestamp":1724198400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,8,21]],"date-time":"2024-08-21T00:00:00Z","timestamp":1724198400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Inflammopharmacol"],"published-print":{"date-parts":[[2024,10]]},"DOI":"10.1007\/s10787-024-01550-8","type":"journal-article","created":{"date-parts":[[2024,8,22]],"date-time":"2024-08-22T15:30:49Z","timestamp":1724340649000},"page":"2781-2800","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Brain resident microglia in Alzheimer\u2019s disease: foe or friends"],"prefix":"10.1007","volume":"32","author":[{"given":"Simranjit","family":"Kaur","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malleshwari","family":"K.","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anamika","family":"Sharma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vijayasree V.","family":"Giridharan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5412-7547","authenticated-orcid":false,"given":"Manoj P.","family":"Dandekar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,8,21]]},"reference":[{"issue":"9","key":"1550_CR1","doi-asserted-by":"publisher","first-page":"548","DOI":"10.1136\/jclinpath-2020-206927","volume":"74","author":"MA Al Barashdi","year":"2021","unstructured":"Al Barashdi MA, Ali A, McMullin MF, Mills K (2021) Protein tyrosine phosphatase receptor type C (PTPRC or CD45).\u00a0J Clin Pathol 74(9):548\u2013552.\u00a0https:\/\/doi.org\/10.1136\/jclinpath-2020-206927","journal-title":"J Clin Pathol"},{"issue":"10","key":"1550_CR2","doi-asserted-by":"publisher","first-page":"1289","DOI":"10.1016\/j.bbabio.2008.07.004","volume":"1777","author":"A Atlante","year":"2008","unstructured":"Atlante A, Amadoro G, Bobba A, De Bari L, Corsetti V, Pappalardo G, Passarella SJB (2008) A peptide containing residues 26\u201344 of tau protein impairs mitochondrial oxidative phosphorylation acting at the level of the adenine nucleotide translocator. Biochimica Et Biophysica Acta BBA Bioenergetics 1777(10):1289\u20131300","journal-title":"Biochimica Et Biophysica Acta BBA Bioenergetics"},{"issue":"8","key":"1550_CR3","doi-asserted-by":"publisher","first-page":"2044","DOI":"10.1016\/j.celrep.2018.10.092","volume":"25","author":"J Baardman","year":"2018","unstructured":"Baardman J, Verberk SG, Prange KH, van Weeghel M, van der Velden S, Ryan DG, Denis SWJC, r. (2018) A defective pentose phosphate pathway reduces inflammatory macrophage responses during hypercholesterolemia. Cell Rep 25(8):2044-2052.e2045","journal-title":"Cell Rep"},{"issue":"3","key":"1550_CR4","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1016\/j.cmet.2019.06.005","volume":"30","author":"SH Baik","year":"2019","unstructured":"Baik SH, Kang S, Lee W, Choi H, Chung S, Kim J-I, Mook-Jung IJC (2019) A breakdown in metabolic reprogramming causes microglia dysfunction in Alzheimer\u2019s disease. Cell Metab 30(3):493-507.e496","journal-title":"Cell Metab"},{"issue":"16","key":"1550_CR5","doi-asserted-by":"publisher","first-page":"1567","DOI":"10.1056\/nejmc1306509","volume":"369","author":"BA Benitez","year":"2013","unstructured":"Benitez BA, Cruchaga C (2013) TREM2 and neurodegenerative disease. The New England journal of medicine 369(16):1567\u20131568.\u00a0https:\/\/doi.org\/10.1056\/nejmc1306509","journal-title":"The New England journal of medicine"},{"key":"1550_CR6","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2022.110019","volume":"363","author":"A Bi","year":"2022","unstructured":"Bi A, Wang Y, Chen L, Yin Z, Luo L (2022) \u03b3-Glutamylcysteine attenuates amyloid-\u03b2 oligomers-induced neuroinflammation in microglia via blocking NF-\u03baB signaling pathway. Chem Biol Interact 363:110019. https:\/\/doi.org\/10.1016\/j.cbi.2022.110019","journal-title":"Chem Biol Interact"},{"issue":"5","key":"1550_CR7","doi-asserted-by":"publisher","first-page":"826","DOI":"10.1002\/glia.22966","volume":"64","author":"K Bisht","year":"2016","unstructured":"Bisht K, Sharma KP, Lecours C, Gabriela S\u00e1nchez M, El Hajj H, Milior G, Vallieres LJG (2016) Dark microglia: a new phenotype predominantly associated with pathological states. Glia 64(5):826\u2013839","journal-title":"Glia"},{"issue":"1","key":"1550_CR8","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1146\/annurev-genet-112618-043515","volume":"53","author":"CJ Bohlen","year":"2019","unstructured":"Bohlen CJ, Friedman BA, Dejanovic B, Sheng MJAR (2019) Microglia in brain development, homeostasis and neurodegeneration. Annu Rev Genet 53(1):263\u2013288","journal-title":"Annu Rev Genet"},{"issue":"16","key":"1550_CR9","doi-asserted-by":"publisher","first-page":"4283","DOI":"10.1523\/jneurosci.4814-07.2008","volume":"28","author":"T Bolmont","year":"2008","unstructured":"Bolmont T, Haiss F, Eicke D, Radde R, Mathis CA, Klunk WE, Calhoun ME (2008) Dynamics of the microglial\/amyloid interaction indicate a role in plaque maintenance. J Neurosci 28(16):4283\u20134292. https:\/\/doi.org\/10.1523\/jneurosci.4814-07.2008","journal-title":"J Neurosci"},{"key":"1550_CR10","doi-asserted-by":"publisher","first-page":"177","DOI":"10.3389\/fnagi.2019.00177","volume":"11","author":"N Braidy","year":"2019","unstructured":"Braidy N, Zarka M, Jugder BE, Welch J, Jayasena T, Chan DKY, Bridge W (2019) The precursor to glutathione (GSH), gamma-glutamylcysteine (GGC), can ameliorate oxidative damage and neuroinflammation induced by abeta(40) oligomers in human astrocytes. Front Aging Neurosci 11:177. https:\/\/doi.org\/10.3389\/fnagi.2019.00177","journal-title":"Front Aging Neurosci"},{"issue":"1","key":"1550_CR11","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1038\/nn.3599","volume":"17","author":"O Butovsky","year":"2014","unstructured":"Butovsky O, Jedrychowski MP, Moore CS, Cialic R, Lanser AJ, Gabriely G, Doykan CEJN (2014) Identification of a unique TGF-\u03b2\u2013dependent molecular and functional signature in microglia. Nat Neurosci 17(1):131\u2013143","journal-title":"Nat Neurosci"},{"key":"1550_CR12","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioorg.2022.105854","author":"C-Y Cao","year":"2022","unstructured":"Cao C-Y, Yang Y-X, Xie Z, Chen X, Shi X-W, Yin X, Gao J-MJBC (2022) Derivatives of sarcodonin A isolated from Sarcodon scabrosus reversed LPS-induced M1 polarization in microglia through MAPK\/NF-\u03baB pathway. Bioorganic Chem. https:\/\/doi.org\/10.1016\/j.bioorg.2022.105854","journal-title":"Bioorganic Chem"},{"key":"1550_CR13","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2014.06.004","author":"Y Chen","year":"2014","unstructured":"Chen Y, Zhao Y, Dai C-L, Liang Z, Run X, Iqbal K, Gong C-XJE (2014) Intranasal insulin restores insulin signaling, increases synaptic proteins, and reduces A\u03b2 level and microglia activation in the brains of 3xTg-AD mice. Exp Neurol. https:\/\/doi.org\/10.1016\/j.expneurol.2014.06.004","journal-title":"Exp Neurol"},{"issue":"3","key":"1550_CR14","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1038\/nm.3806","volume":"21","author":"RC Coll","year":"2015","unstructured":"Coll RC, Robertson AA, Chae JJ, Higgins SC, Mu\u00f1oz-Planillo R, Inserra MC, Stutz AJN (2015) A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases. Nat Med 21(3):248\u2013255","journal-title":"Nat Med"},{"key":"1550_CR15","unstructured":"Conejo Gonz\u00e1lez C. (2015) Neuroinflammation in Alzheimer's disease and Down syndrome"},{"issue":"16","key":"1550_CR16","doi-asserted-by":"publisher","first-page":"3295","DOI":"10.1093\/hmg\/ddq221","volume":"19","author":"JJ Corneveaux","year":"2010","unstructured":"Corneveaux JJ, Myers AJ, Allen AN, Pruzin JJ, Ramirez M, Engel A, ... Huentelman MJ (2010) Association of CR1, CLU and PICALM with Alzheimer's disease in a cohort of clinically characterized and neuropathologically verified individuals.\u00a0Hum Mol Genet 19(16):3295\u20133301.\u00a0https:\/\/doi.org\/10.1093\/hmg\/ddq221","journal-title":"Hum Mol Genet"},{"issue":"3","key":"1550_CR17","doi-asserted-by":"publisher","first-page":"306","DOI":"10.1111\/j.1365-2990.2008.01006.x","volume":"35","author":"M Cosenza-Nashat","year":"2009","unstructured":"Cosenza-Nashat M, Zhao ML, Suh HS, Morgan J, Natividad R, Morgello S (2009) Expression of the translocator protein of 18 kDa by microglia, macrophages and astrocytes based on immunohistochemical localization in abnormal human brain. Neuropathol App Neurobiol 35(3):306\u2013328","journal-title":"Neuropathol App Neurobiol"},{"key":"1550_CR18","doi-asserted-by":"publisher","first-page":"444","DOI":"10.3389\/fnins.2020.00444","volume":"14","author":"W Cui","year":"2020","unstructured":"Cui W, Sun C, Ma Y, Wang S, Wang X, Zhang Y (2020) Inhibition of TLR4 Induces M2 microglial polarization and provides neuroprotection via the NLRP3 inflammasome in Alzheimer\u2019s disease. Front Neurosci 14:444. https:\/\/doi.org\/10.3389\/fnins.2020.00444","journal-title":"Front Neurosci"},{"issue":"5","key":"1550_CR19","doi-asserted-by":"publisher","first-page":"1073","DOI":"10.1016\/j.cell.2018.05.003","volume":"173","author":"A Deczkowska","year":"2018","unstructured":"Deczkowska A, Keren-Shaul H, Weiner A, Colonna M, Schwartz M, Amit I (2018) Disease-associated microglia: a universal immune sensor of neurodegeneration. Cell 173(5):1073\u20131081. https:\/\/doi.org\/10.1016\/j.cell.2018.05.003","journal-title":"Cell"},{"key":"1550_CR20","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2016.12.014","author":"C Dempsey","year":"2017","unstructured":"Dempsey C, Araiz AR, Bryson K, Finucane O, Larkin C, Mills E (2017) Inhibiting the NLRP3 inflammasome with MCC950 promotes non-phlogistic clearance of amyloid-\u03b2 and cognitive function in APP\/PS1 mice. Brain Behav Immunity. https:\/\/doi.org\/10.1016\/j.bbi.2016.12.014","journal-title":"Brain Behav Immunity"},{"key":"1550_CR119","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1186\/1742-2094-11-48","volume":"11","author":"D Doens","year":"2014","unstructured":"Doens D, Fern\u00e1ndez PL (2014) Microglia receptors and their implications in the response to amyloid \u03b2 for\nAlzheimer\u2019s disease pathogenesis. J Neuroinflammation 11:48. https:\/\/doi.org\/10.1186\/1742-2094-11-48","journal-title":"J Neuroinflammation"},{"key":"1550_CR21","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2021.659843","volume":"15","author":"MA Dixon","year":"2021","unstructured":"Dixon MA, Greferath U, Fletcher EL, Jobling AI (2021) The contribution of microglia to the development and maturation of the visual system. Front Cell Neurosci 15:659843. https:\/\/doi.org\/10.3389\/fncel.2021.659843","journal-title":"Front Cell Neurosci"},{"key":"1550_CR22","doi-asserted-by":"publisher","unstructured":"Du H, Guo L, Fang F, Chen D, Sosunov AA, McKhann GM, Yan Y, Wang C, Zhang H, Molkentin JD, Gunn-Moore FJ, Vonsattel JP, Arancio O, Chen JX, Yan SD. Cyclophilin D deficiency attenuates mitochondrial and neuronal perturbation and ameliorates learning and memory in Alzheimer's disease. Nat Med. 2008 Oct;14(10):1097-105. https:\/\/doi.org\/10.1038\/nm.1868. Epub 2008 Sep 21. PMID: 18806802; PMCID: PMC2789841.","DOI":"10.1038\/nm.1868"},{"issue":"8","key":"1550_CR23","first-page":"1963","volume":"109","author":"CC Escoubas","year":"2021","unstructured":"Escoubas CC, Dorman LC, Nguyen PT, Lagares-Linares C, Nakajo H, Anderson SR, Xiao YJ (2021) Type I interferon responsive microglia shape cortical development and behavior. Cell 109(8):1963\u20131954","journal-title":"Cell"},{"issue":"2\u20134","key":"1550_CR24","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1016\/j.imbio.2005.05.010","volume":"210","author":"BO Fabriek","year":"2005","unstructured":"Fabriek BO, Dijkstra CD, van den Berg TK (2005) The macrophage scavenger receptor CD163. Immunobiology 210(2-4):153\u2013160.\u00a0https:\/\/doi.org\/10.1016\/j.imbio.2005.05.010","journal-title":"Immunobiology"},{"key":"1550_CR25","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.624538","author":"LH Fairley","year":"2021","unstructured":"Fairley LH, Wong JH, Barron AMJF (2021) Mitochondrial regulation of microglial immunometabolism in Alzheimer\u2019s disease. Front Immunol. https:\/\/doi.org\/10.3389\/fimmu.2021.624538","journal-title":"Front Immunol"},{"issue":"12","key":"1550_CR26","doi-asserted-by":"publisher","first-page":"3685","DOI":"10.1093\/brain\/awv288","volume":"138","author":"Z Fan","year":"2015","unstructured":"Fan Z, Okello AA, Brooks DJ, Edison P (2015) Longitudinal influence of microglial activation and amyloid on neuronal function in Alzheimer\u2019s disease. Brain 138(12):3685\u20133698","journal-title":"Brain"},{"issue":"3","key":"1550_CR27","doi-asserted-by":"publisher","first-page":"1422","DOI":"10.1007\/s12035-013-8620-6","volume":"49","author":"R Fu","year":"2014","unstructured":"Fu R, Shen Q, Xu P, Luo JJ, Tang Y (2014) Phagocytosis of microglia in the central nervous system diseases. Mol Neurobiol 49(3):1422\u20131434. https:\/\/doi.org\/10.1007\/s12035-013-8620-6","journal-title":"Mol Neurobiol"},{"issue":"1","key":"1550_CR28","doi-asserted-by":"publisher","first-page":"186","DOI":"10.1186\/s12974-023-02869-9","volume":"20","author":"EF Garland","year":"2023","unstructured":"Garland EF, Dennett O, Lau LC, Chatelet DS, Bottlaender M, Nicoll JAR, Boche D (2023) The mitochondrial protein TSPO in Alzheimer\u2019s disease: relation to the severity of AD pathology and the neuroinflammatory environment. J Neuroinflamm 20(1):186. https:\/\/doi.org\/10.1186\/s12974-023-02869-9","journal-title":"J Neuroinflamm"},{"key":"1550_CR29","doi-asserted-by":"publisher","first-page":"229","DOI":"10.3389\/fncel.2013.00229","volume":"7","author":"C Gemma","year":"2013","unstructured":"Gemma C, Bachstetter AD (2013) The role of microglia in adult hippocampal neurogenesis. Front Cell Neurosci 7:229. https:\/\/doi.org\/10.3389\/fncel.2013.00229","journal-title":"Front Cell Neurosci"},{"key":"1550_CR30","doi-asserted-by":"publisher","DOI":"10.1093\/braincomms\/fcaa227","author":"KR Giordano","year":"2021","unstructured":"Giordano KR, Denman CR, Dubisch PS, Akhter M, Lifshitz J (2021) An update on the rod microglia variant in experimental and clinical brain injury and disease. Brain Commun. https:\/\/doi.org\/10.1093\/braincomms\/fcaa227","journal-title":"Brain Commun"},{"issue":"1","key":"1550_CR31","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1186\/s12974-022-02472-4","volume":"19","author":"VV Giridharan","year":"2022","unstructured":"Giridharan VV, Generoso JS, Lence L, Candiotto G, Streck E, Petronilho F, Barichello T (2022) A crosstalk between gut and brain in sepsis-induced cognitive decline. J Neuroinflamm 19(1):114. https:\/\/doi.org\/10.1186\/s12974-022-02472-4","journal-title":"J Neuroinflamm"},{"issue":"19","key":"1550_CR32","doi-asserted-by":"publisher","first-page":"3752","DOI":"10.1523\/JNEUROSCI.2070-18.2019","volume":"39","author":"J Gong","year":"2019","unstructured":"Gong J, Szego \u00c9M, Leonov A, Benito E, Becker S, Fischer A, Schneider AJJ (2019) Translocator protein ligand protects against neurodegeneration in the MPTP mouse model of Parkinsonism. J Neurosci 39(19):3752\u20133769","journal-title":"J Neurosci"},{"key":"1550_CR33","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12964-015-0099-5","volume":"13","author":"M Gutknecht","year":"2015","unstructured":"Gutknecht M, Geiger J, Joas S, D\u00f6rfel D, Salih HR, M\u00fcller MR (2015) The transcription factor mitf is a critical regulator of gpnmb expression in dendritic cells. Cell Commun Signal 13:1\u201315","journal-title":"Cell Commun Signal"},{"key":"1550_CR34","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioadv.2022.212770","volume":"136","author":"Y Hao","year":"2022","unstructured":"Hao Y, Su C, Liu X, Sui H, Shi Y, Zhao LJBA (2022) Bioengineered microglia-targeted exosomes facilitate a\u03b2 clearance via enhancing activity of microglial lysosome for promoting cognitive recovery in Alzheimer\u2019s Disease. Biomater Adv 136:212770","journal-title":"Biomater Adv"},{"issue":"10","key":"1550_CR35","doi-asserted-by":"publisher","first-page":"1088","DOI":"10.1038\/ng.440","volume":"41","author":"D Harold","year":"2009","unstructured":"Harold D, Abraham R, Hollingworth P, Sims R, Gerrish A, Hamshere ML,  Williams J (2009) Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease. Nature genetics 41(10):1088\u20131093. https:\/\/doi.org\/10.1038\/ng.440","journal-title":"Nature genetics"},{"issue":"7434","key":"1550_CR36","doi-asserted-by":"publisher","first-page":"674","DOI":"10.1038\/nature11729","volume":"493","author":"MT Heneka","year":"2013","unstructured":"Heneka MT, Kummer MP, Stutz A, Delekate A, Schwartz S, Vieira-Saecker A, Golenbock DT (2013b) NLRP3 is activated in Alzheimer\u2019s disease and contributes to pathology in APP\/PS1 mice. Nature 493(7434):674\u2013678. https:\/\/doi.org\/10.1038\/nature11729","journal-title":"Nature"},{"issue":"7434","key":"1550_CR37","doi-asserted-by":"publisher","first-page":"674","DOI":"10.1038\/nature11729","volume":"493","author":"MT Heneka","year":"2013","unstructured":"Heneka MT, Kummer MP, Stutz A, Delekate A, Schwartz S, Vieira-Saecker A, Tzeng TC (2013a) NLRP3 is activated in Alzheimer\u2019s disease and contributes to pathology in APP\/PS1 mice. Nature 493(7434):674\u2013678","journal-title":"Nature"},{"issue":"12","key":"1550_CR38","doi-asserted-by":"publisher","first-page":"1896","DOI":"10.1038\/nn.3554","volume":"16","author":"SE Hickman","year":"2013","unstructured":"Hickman SE, Kingery ND, Ohsumi TK, Borowsky ML, Wang LC, Means TK, El Khoury J (2013) The microglial sensome revealed by direct RNA sequencing. Nat Neurosci 16(12):1896\u20131905","journal-title":"Nat Neurosci"},{"issue":"12","key":"1550_CR39","doi-asserted-by":"publisher","first-page":"1316","DOI":"10.1038\/mp.2011.125","volume":"17","author":"P Hollingworth","year":"2012","unstructured":"Hollingworth P, Sweet R, Sims R, Harold D, Russo G, Abraham R (2012) King\u2019s research portal. Mol Psychiatry 17(12):1316\u20131327.\u00a0https:\/\/doi.org\/10.1038\/mp.2011.125","journal-title":"Mol Psychiatry"},{"key":"1550_CR40","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1186\/1741-7007-10-7","volume":"10","author":"ML Howe","year":"2012","unstructured":"Howe ML, Barres BA (2012) A novel role for microglia in minimizing excitotoxicity. BMC Biol 10:7. https:\/\/doi.org\/10.1186\/1741-7007-10-7","journal-title":"BMC Biol"},{"issue":"10","key":"1550_CR41","doi-asserted-by":"publisher","first-page":"109228","DOI":"10.1016\/j.celrep.2021.109228","volume":"35","author":"Y Hu","year":"2021","unstructured":"Hu Y, Fryatt GL, Ghorbani M, Obst J, Menassa DA, Martin-Estebane M, Muntslag TA, Olmos-Alonso A, Guerrero-Carrasco M, Thomas D, Cragg MS (2021) Replicative senescence dictates the emergence of disease-associated microglia and contributes to A\u03b2 pathology. Cell Rep 35(10):109228","journal-title":"Cell Rep"},{"issue":"1","key":"1550_CR42","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s40478-018-0612-3","volume":"6","author":"M H\u00fcttenrauch","year":"2018","unstructured":"H\u00fcttenrauch M, Ogorek I, Klafki H, Otto M, Stadelmann C, Weggen S, Wirths O (2018) Glycoprotein NMB: a novel Alzheimer\u2019s disease associated marker expressed in a subset of activated microglia. Acta Neuropathol Commun 6(1):1\u201314","journal-title":"Acta Neuropathol Commun"},{"key":"1550_CR43","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.physbeh.2017.03.040","volume":"176","author":"P Hyochol Ahn","year":"2017","unstructured":"Hyochol Ahn P, Michael Weaver PhD, Debra Lyon PhD, Eunyoung Choi RN, Fillingim RB, Tumbar P (2017) HHS public access. Physiol Behav 176:139\u2013148","journal-title":"Physiol Behav"},{"issue":"2","key":"1550_CR44","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1016\/j.tcb.2012.10.006","volume":"23","author":"K Itoh","year":"2013","unstructured":"Itoh K, Nakamura K, Iijima M, Sesaki H (2013) Mitochondrial dynamics in neurodegeneration. Trends Cell Biol 23(2):64\u201371. https:\/\/doi.org\/10.1016\/j.tcb.2012.10.006","journal-title":"Trends Cell Biol"},{"key":"1550_CR45","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2021.699623","author":"AH Jassim","year":"2021","unstructured":"Jassim AH, Inman DM, Mitchell CH (2021) Crosstalk between dysfunctional mitochondria and inflammation in glaucomatous neurodegeneration. Front Pharmacol. https:\/\/doi.org\/10.3389\/fphar.2021.699623","journal-title":"Front Pharmacol"},{"key":"1550_CR46","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2022.113317","author":"F Jie","year":"2022","unstructured":"Jie F, Yang X, Yang B, Liu Y, Wu L, Lu BJB (2022) Stigmasterol attenuates inflammatory response of microglia via NF-\u03baB and NLRP3 signaling by AMPK activation. Biomed Pharmacother. https:\/\/doi.org\/10.1016\/j.biopha.2022.113317","journal-title":"Biomed Pharmacother"},{"issue":"2","key":"1550_CR47","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1056\/NEJMoa1211103","volume":"368","author":"T Jonsson","year":"2013","unstructured":"Jonsson T, Stefansson H, Steinberg S, Jonsdottir I, Jonsson PV, Snaedal J, ... Stefansson K (2013) Variant of TREM2 associated with the risk of Alzheimer's disease.\u00a0N Engl J Med 368(2) 107\u2013116","journal-title":"N Engl J Med"},{"issue":"5","key":"1550_CR48","doi-asserted-by":"publisher","first-page":"6128","DOI":"10.18632\/oncotarget.23640","volume":"9","author":"AU Joshi","year":"2018","unstructured":"Joshi AU, Saw NL, Shamloo M, Mochly-Rosen DJO (2018) Drp1\/Fis1 interaction mediates mitochondrial dysfunction, bioenergetic failure and cognitive decline in Alzheimer\u2019s disease. Oncotarget 9(5):6128","journal-title":"Oncotarget"},{"issue":"10","key":"1550_CR49","doi-asserted-by":"publisher","first-page":"1635","DOI":"10.1038\/s41593-019-0486-0","volume":"22","author":"AU Joshi","year":"2019","unstructured":"Joshi AU, Minhas PS, Liddelow SA, Haileselassie B, Andreasson KI, Dorn GW, Mochly-Rosen D (2019) Fragmented mitochondria released from microglia trigger A1 astrocytic response and propagate inflammatory neurodegeneration. Nat Neurosci 22(10):1635\u20131648","journal-title":"Nat Neurosci"},{"key":"1550_CR50","doi-asserted-by":"publisher","first-page":"198","DOI":"10.3389\/fncel.2020.00198","volume":"14","author":"AM Jurga","year":"2020","unstructured":"Jurga AM, Paleczna M, Kuter KZ (2020) Overview of general and discriminating markers of differential microglia phenotypes. Front Cell Neurosci 14:198. https:\/\/doi.org\/10.3389\/fncel.2020.00198","journal-title":"Front Cell Neurosci"},{"key":"1550_CR51","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1016\/j.bbi.2022.10.009","volume":"107","author":"MSJ Kater","year":"2023","unstructured":"Kater MSJ, Huffels CFM, Oshima T, Renckens NS, Middeldorp J, Boddeke EWGM, Verheijen MHG (2023) Prevention of microgliosis halts early memory loss in a mouse model of Alzheimer\u2019s disease. Brain Behav Immun 107:225\u2013241. https:\/\/doi.org\/10.1016\/j.bbi.2022.10.009","journal-title":"Brain Behav Immun"},{"issue":"9","key":"1550_CR52","doi-asserted-by":"publisher","first-page":"736","DOI":"10.1093\/jnen\/nlx056","volume":"76","author":"C Kaur","year":"2017","unstructured":"Kaur C, Rathnasamy G, Ling EA (2017) Biology of microglia in the developing brain. J Neuropathol Exp Neurol 76(9):736\u2013753. https:\/\/doi.org\/10.1093\/jnen\/nlx056","journal-title":"J Neuropathol Exp Neurol"},{"issue":"7","key":"1550_CR53","doi-asserted-by":"publisher","first-page":"1276","DOI":"10.1016\/j.cell.2017.05.018","volume":"169","author":"H Keren-Shaul","year":"2017","unstructured":"Keren-Shaul H, Spinrad A, Weiner A, Matcovitch-Natan O, Dvir-Szternfeld R, Ulland TK, Toth BJC (2017) A unique microglia type associated with restricting development of Alzheimer\u2019s disease. Cell 169(7):1276-1290.e1217","journal-title":"Cell"},{"issue":"7","key":"1550_CR54","doi-asserted-by":"publisher","first-page":"1122","DOI":"10.1002\/glia.22501","volume":"61","author":"J Kopatz","year":"2013","unstructured":"Kopatz J, Beutner C, Welle K, Bodea LG, Reinhardt J, Claude J, Linnartz-Gerlach B, Neumann H (2013) Siglec-h on activated microglia for recognition and engulfment of glioma cells. Glia 61(7):1122\u20131133. https:\/\/doi.org\/10.1002\/glia.22501","journal-title":"Glia"},{"issue":"3","key":"1550_CR55","doi-asserted-by":"publisher","first-page":"566","DOI":"10.1016\/j.immuni.2017.08.008","volume":"47","author":"S Krasemann","year":"2017","unstructured":"Krasemann S, Madore C, Cialic R, Baufeld C, Calcagno N, El Fatimy R, Fanek Z (2017) The TREM2-APOE pathway drives the transcriptional phenotype of dysfunctional microglia in neurodegenerative diseases. Immunity 47(3):566\u2013581569","journal-title":"Immunity"},{"issue":"4","key":"1550_CR56","doi-asserted-by":"publisher","first-page":"1769","DOI":"10.3233\/JAD-210400","volume":"82","author":"R Kuwar","year":"2021","unstructured":"Kuwar R, Rolfe A, Di L, Blevins H, Xu Y, Sun X, Sun D (2021) A novel inhibitor targeting NLRP3 inflammasome reduces neuropathology and improves cognitive function in Alzheimer\u2019s Disease transgenic mice. J Alzheimers Dis 82(4):1769\u20131783. https:\/\/doi.org\/10.3233\/JAD-210400","journal-title":"J Alzheimers Dis"},{"issue":"12","key":"1550_CR57","doi-asserted-by":"publisher","first-page":"2499","DOI":"10.4103\/1673-5374.313050","volume":"16","author":"GP Lang","year":"2021","unstructured":"Lang GP, Li C, Han YY (2021) Rutin pretreatment promotes microglial M1 to M2 phenotype polarization. Neural Regen Res 16(12):2499\u20132504. https:\/\/doi.org\/10.4103\/1673-5374.313050","journal-title":"Neural Regen Res"},{"key":"1550_CR58","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1016\/j.pneurobio.2015.05.002","volume":"131","author":"R Lardenoije","year":"2015","unstructured":"Lardenoije R, Iatrou A, Kenis G, Kompotis K, Steinbusch HW, Mastroeni D, van den Hove DLJP (2015) The epigenetics of aging and neurodegeneration. Progress Neurobiol 131:21\u201364","journal-title":"Progress Neurobiol"},{"issue":"4","key":"1550_CR59","doi-asserted-by":"publisher","first-page":"1045","DOI":"10.3233\/JAD-190127","volume":"72","author":"I Lejri","year":"2019","unstructured":"Lejri I, Grimm A, Hall\u00e9 F, Abarghaz M, Klein C, Maitre M, Bihel F (2019) TSPO ligands boost mitochondrial function and pregnenolone synthesis. J Alzheimer\u2019s Dis 72(4):1045\u20131058","journal-title":"J Alzheimer's Dis"},{"issue":"3","key":"1550_CR60","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1038\/s41582-020-00435-y","volume":"17","author":"F Leng","year":"2021","unstructured":"Leng F, Edison PJNRN (2021) Neuroinflammation and microglial activation in Alzheimer disease: where do we go from here? Nat Rev Neurol 17(3):157\u2013172","journal-title":"Nat Rev Neurol"},{"key":"1550_CR61","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2021.736310","volume":"15","author":"J Li","year":"2021","unstructured":"Li J, Shui X, Sun R, Wan L, Zhang B, Xiao B, Luo Z (2021) Microglial phenotypic transition: signaling pathways and influencing modulators involved in regulation in central nervous system diseases. Front Cell Neurosci 15:736310. https:\/\/doi.org\/10.3389\/fncel.2021.736310","journal-title":"Front Cell Neurosci"},{"issue":"9","key":"1550_CR62","doi-asserted-by":"publisher","first-page":"676","DOI":"10.2174\/1567205018666211105140732","volume":"18","author":"X Liang","year":"2021","unstructured":"Liang X, Wu H, Colt M, Guo X, Pluimer B, Zeng J, Zhao Z (2021) Microglia and its genetics in Alzheimer\u2019s disease. Current Alzheimer Res 18(9):676","journal-title":"Current Alzheimer Res"},{"issue":"50","key":"1550_CR63","doi-asserted-by":"publisher","first-page":"32145","DOI":"10.1073\/pnas.2009680117","volume":"117","author":"N Lonnemann","year":"2020","unstructured":"Lonnemann N, Hosseini S, Marchetti C, Skouras DB, Stefanoni D, D\u2019Alessandro A, Korte M (2020) The NLRP3 inflammasome inhibitor OLT1177 rescues cognitive impairment in a mouse model of Alzheimer\u2019s disease. Proc Natl Acad Sci U S A 117(50):32145\u201332154. https:\/\/doi.org\/10.1073\/pnas.2009680117","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"6","key":"1550_CR64","doi-asserted-by":"publisher","first-page":"e52013","DOI":"10.15252\/embr.202052013","volume":"22","author":"J Lu","year":"2021","unstructured":"Lu J, Zhou W, Dou F, Wang C, Yu ZJE, r. (2021) TRPV1 sustains microglial metabolic reprogramming in Alzheimer\u2019s disease. EMBO Rep 22(6):e52013","journal-title":"EMBO Rep"},{"issue":"1","key":"1550_CR65","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1080\/15548627.2019.1596488","volume":"16","author":"R Luo","year":"2020","unstructured":"Luo R, Su LY, Li G, Yang J, Liu Q, Yang LX, Yao YG (2020) Activation of PPARA-mediated autophagy reduces Alzheimer disease-like pathology and cognitive decline in a murine model. Autophagy 16(1):52\u201369. https:\/\/doi.org\/10.1080\/15548627.2019.1596488","journal-title":"Autophagy"},{"key":"1550_CR66","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2022.105615","volume":"164","author":"SI Machlovi","year":"2022","unstructured":"Machlovi SI, Neuner SM, Hemmer BM, Khan R, Liu Y, Huang M, Goate AM (2022) APOE4 confers transcriptomic and functional alterations to primary mouse microglia. Neurobiol Dis 164:105615. https:\/\/doi.org\/10.1016\/j.nbd.2022.105615","journal-title":"Neurobiol Dis"},{"key":"1550_CR67","doi-asserted-by":"publisher","DOI":"10.1101\/2024.01.18.576313","author":"LN Madhu","year":"2024","unstructured":"Madhu LN, Kodali M, Upadhya R, Rao S, Shuai B, Somayaji Y, Shetty AK (2024) Intranasally administered EVs from hiPSCderived NSCs alter the transcriptomic profile of activated microglia and conserve brain function in an Alzheimer\u2019s model. BioRxiv. https:\/\/doi.org\/10.1101\/2024.01.18.576313","journal-title":"BioRxiv"},{"issue":"1","key":"1550_CR68","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1006\/exnr.1998.6863","volume":"153","author":"MP Mattson","year":"1998","unstructured":"Mattson MP, Keller JN, Begley JGJE (1998) Evidence for synaptic apoptosis. Exp Neurol 153(1):35\u201348","journal-title":"Exp Neurol"},{"issue":"1","key":"1550_CR69","doi-asserted-by":"publisher","first-page":"186","DOI":"10.1007\/s13311-021-01179-3","volume":"19","author":"KN McFarland","year":"2022","unstructured":"McFarland KN, Chakrabarty P (2022) Microglia in Alzheimer\u2019s disease: a key player in the transition between homeostasis and pathogenesis. Neurotherapeutics 19(1):186\u2013208. https:\/\/doi.org\/10.1007\/s13311-021-01179-3","journal-title":"Neurotherapeutics"},{"issue":"3","key":"1550_CR70","doi-asserted-by":"publisher","first-page":"1449","DOI":"10.4049\/jimmunol.160.3.1449","volume":"160","author":"CM McManus","year":"1998","unstructured":"McManus CM, Brosnan CF, Berman JW (1998) Cytokine induction of MIP-1 alpha and MIP-1 beta in human fetal microglia. J Immunol 160(3):1449\u20131455","journal-title":"J Immunol"},{"key":"1550_CR71","doi-asserted-by":"publisher","first-page":"1201982","DOI":"10.3389\/fnagi.2023.1201982","volume":"15","author":"J Miao","year":"2023","unstructured":"Miao J, Ma H, Yang Y, Liao Y, Lin C, Zheng J, Lan J (2023) Microglia in Alzheimer\u2019s disease: pathogenesis, mechanisms, and therapeutic potentials. Front Aging Neurosci 15:1201982. https:\/\/doi.org\/10.3389\/fnagi.2023.1201982","journal-title":"Front Aging Neurosci"},{"key":"1550_CR72","doi-asserted-by":"publisher","DOI":"10.1016\/j.conb.2022.102674","volume":"79","author":"A Mordelt","year":"2023","unstructured":"Mordelt A, de Witte LD (2023) Microglia-mediated synaptic pruning as a key deficit in neurodevelopmental disorders: Hype or hope? Curr Opin Neurobiol 79:102674. https:\/\/doi.org\/10.1016\/j.conb.2022.102674","journal-title":"Curr Opin Neurobiol"},{"issue":"1","key":"1550_CR73","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1186\/s12974-024-03066-y","volume":"21","author":"RC Ng","year":"2024","unstructured":"Ng RC, Jian M, Ma OK, Xiang AW, Bunting M, Kwan JS, Chan KH (2024) Liver-specific adiponectin gene therapy suppresses microglial NLRP3-inflammasome activation for treating Alzheimer\u2019s disease. J Neuroinflamm 21(1):77. https:\/\/doi.org\/10.1186\/s12974-024-03066-y","journal-title":"J Neuroinflamm"},{"issue":"1","key":"1550_CR74","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1038\/s41536-020-00107-x","volume":"5","author":"P Norat","year":"2020","unstructured":"Norat P, Soldozy S, Sokolowski JD, Gorick CM, Kumar JS, Chae Y, Levitt MRJNRM (2020) Mitochondrial dysfunction in neurological disorders: exploring mitochondrial transplantation. NPJ Regen Med 5(1):22","journal-title":"NPJ Regen Med"},{"issue":"5","key":"1550_CR75","doi-asserted-by":"publisher","first-page":"524","DOI":"10.3390\/biomedicines9050524","volume":"9","author":"IG Onyango","year":"2021","unstructured":"Onyango IG, Jauregui GV, \u010carn\u00e1 M, Bennett JP Jr, Stokin GBJB (2021) Neuroinflammation in Alzheimer\u2019s Disease. Biomedicines 9(5):524","journal-title":"Biomedicines"},{"issue":"1","key":"1550_CR76","doi-asserted-by":"publisher","first-page":"312","DOI":"10.1186\/s12974-021-02332-7","volume":"18","author":"W Ou","year":"2021","unstructured":"Ou W, Yang J, Simanauskaite J, Choi M, Castellanos DM, Chang R, Sumbria RK (2021) Biologic TNF-alpha inhibitors reduce microgliosis, neuronal loss, and tau phosphorylation in a transgenic mouse model of tauopathy. J Neuroinflamm 18(1):312. https:\/\/doi.org\/10.1186\/s12974-021-02332-7","journal-title":"J Neuroinflamm"},{"issue":"2","key":"1550_CR77","doi-asserted-by":"publisher","first-page":"eaau6328","DOI":"10.1126\/sciadv.aau6328","volume":"5","author":"R-Y Pan","year":"2019","unstructured":"Pan R-Y, Ma J, Kong X-X, Wang X-F, Li S-S, Qi X-L, Jin WJS, a. (2019) Sodium rutin ameliorates Alzheimer\u2019s disease\u2013like pathology by enhancing microglial amyloid-\u03b2 clearance. Sci Adv 5(2):eaau6328","journal-title":"Sci Adv"},{"issue":"6048","key":"1550_CR78","doi-asserted-by":"publisher","first-page":"1456","DOI":"10.1126\/science.1202529","volume":"333","author":"RC Paolicelli","year":"2011","unstructured":"Paolicelli RC, Bolasco G, Pagani F, Maggi L, Scianni M, Panzanelli P, Gross CT (2011) Synaptic pruning by microglia is necessary for normal brain development. Science 333(6048):1456\u20131458. https:\/\/doi.org\/10.1126\/science.1202529","journal-title":"Science"},{"key":"1550_CR79","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1016\/bs.ircmb.2016.08.003","volume":"328","author":"S Patergnani","year":"2017","unstructured":"Patergnani S, Fossati V, Bonora M, Giorgi C, Marchi S, Missiroli S (2017) Mitochondria in multiple sclerosis: molecular mechanisms of pathogenesis. Int Rev Cell Mol Biol 328:49\u2013103","journal-title":"Int Rev Cell Mol Biol"},{"issue":"5","key":"1550_CR80","doi-asserted-by":"publisher","first-page":"238030","DOI":"10.1242\/jcs.238030","volume":"133","author":"C Pedicone","year":"2020","unstructured":"Pedicone C, Fernandes S, Dungan OM, Dormann SM, Viernes DR, Adhikari AA, Kerr WGJJ (2020) Pan-SHIP1\/2 inhibitors promote microglia effector functions essential for CNS homeostasis. J Cell Sci 133(5):238030","journal-title":"J Cell Sci"},{"issue":"122","key":"1550_CR81","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1126\/scisignal.2000500","volume":"3","author":"Q Peng","year":"2010","unstructured":"Peng Q, Malhotra S, Torchia JA, Kerr WG, Coggeshall KM, Humphrey MBJS (2010) TREM2- and DAP12-dependent activation of PI3K requires DAP10 and is inhibited by SHIP1. Sci Signal 3(122):38","journal-title":"Sci Signal"},{"issue":"2","key":"1550_CR82","doi-asserted-by":"publisher","first-page":"206","DOI":"10.1002\/glia.22744","volume":"63","author":"J Preissler","year":"2015","unstructured":"Preissler J, Grosche A, Lede V, Le Duc D, Kr\u00fcgel K, Matyash V, Szulzewsky F, Kallendrusch S, Immig K, Kettenmann H, Bechmann I (2015) Altered microglial phagocytosis in GPR34-deficient mice. Glia 63(2):206\u2013215","journal-title":"Glia"},{"issue":"3","key":"1550_CR83","first-page":"789","volume":"126","author":"X Qi","year":"2013","unstructured":"Qi X, Qvit N, Su Y-C, Mochly-Rosen DJJ (2013) A novel Drp1 inhibitor diminishes aberrant mitochondrial fission and neurotoxicity. J Cell Sci 126(3):789\u2013802","journal-title":"J Cell Sci"},{"key":"1550_CR84","doi-asserted-by":"publisher","DOI":"10.1038\/s41593-024-01620-8","author":"N Rachmian","year":"2024","unstructured":"Rachmian N, Medina S, Cherqui U, Akiva H, Deitch D, Edilbi D, Schwartz M (2024) Identification of senescent, TREM2-expressing microglia in aging and Alzheimer\u2019s disease model mouse brain. Nat Neurosci. https:\/\/doi.org\/10.1038\/s41593-024-01620-8","journal-title":"Nat Neurosci"},{"issue":"1","key":"1550_CR85","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s13024-018-0266-4","volume":"13","author":"S Rangaraju","year":"2018","unstructured":"Rangaraju S, Dammer EB, Raza SA, Gao T, Xiao H, Betarbet R, Lah JJJM (2018) Quantitative proteomics of acutely-isolated mouse microglia identifies novel immune Alzheimer\u2019s disease-related proteins. Mol Neurodegen 13(1):1\u201319","journal-title":"Mol Neurodegen"},{"key":"1550_CR86","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1016\/j.pneurobio.2018.05.006","volume":"173","author":"G Rathnasamy","year":"2019","unstructured":"Rathnasamy G, Foulds WS, Ling EA, Kaur C (2019) Retinal microglia - A key player in healthy and diseased retina. Prog Neurobiol 173:18\u201340. https:\/\/doi.org\/10.1016\/j.pneurobio.2018.05.006","journal-title":"Prog Neurobiol"},{"issue":"5","key":"1550_CR87","doi-asserted-by":"publisher","first-page":"768","DOI":"10.1002\/ana.26465","volume":"92","author":"B-S Rauchmann","year":"2022","unstructured":"Rauchmann B-S, Brendel M, Franzmeier N, Trappmann L, Zaganjori M, Ersoezlue E, Perneczky R (2022) Microglial activation and connectivity in Alzheimer Disease and aging. Ann Neurol 92(5):768\u2013781. https:\/\/doi.org\/10.1002\/ana.26465","journal-title":"Ann Neurol"},{"issue":"4","key":"1550_CR88","doi-asserted-by":"publisher","first-page":"2397","DOI":"10.1002\/alz.13699","volume":"20","author":"SM Rossano","year":"2024","unstructured":"Rossano SM, Johnson AS, Smith A, Ziaggi G, Roetman A, Guzman D, Lao P (2024) Microglia measured by TSPO PET are associated with Alzheimer\u2019s disease pathology and mediate key steps in a disease progression model. Alzheimers Dement 20(4):2397\u20132407. https:\/\/doi.org\/10.1002\/alz.13699","journal-title":"Alzheimers Dement"},{"issue":"5","key":"1550_CR89","doi-asserted-by":"publisher","first-page":"879","DOI":"10.1016\/j.immuni.2022.03.018","volume":"55","author":"ER Roy","year":"2022","unstructured":"Roy ER, Chiu G, Li S, Propson NE, Kanchi R, Wang B, Cao WJI (2022) Concerted type I interferon signaling in microglia and neural cells promotes memory impairment associated with amyloid \u03b2 plaques. Immunity 55(5):879\u2013894876","journal-title":"Immunity"},{"key":"1550_CR90","doi-asserted-by":"publisher","first-page":"902372","DOI":"10.3389\/fncel.2022.902372","volume":"16","author":"C Ruan","year":"2022","unstructured":"Ruan C, Elyaman W (2022) A New Understanding of TMEM119 as a Marker of Microglia. Front Cell Neurosci 16:902372.\u00a0https:\/\/doi.org\/10.3389\/fncel.2022.902372","journal-title":"Front Cell Neurosci"},{"issue":"9","key":"1550_CR91","doi-asserted-by":"publisher","first-page":"3240","DOI":"10.1172\/jci90606","volume":"127","author":"H Sarlus","year":"2017","unstructured":"Sarlus H, Heneka MT (2017) Microglia in Alzheimer\u2019s disease. J Clin Invest 127(9):3240\u20133249. https:\/\/doi.org\/10.1172\/jci90606","journal-title":"J Clin Invest"},{"key":"1550_CR92","first-page":"13","volume-title":"Morphology of microglia across contexts of health and disease","author":"JC Savage","year":"2019","unstructured":"Savage JC, Carrier M, Tremblay M-\u00c8JM (2019) Morphology of microglia across contexts of health and disease. In: Olga G, Alexei V (eds) Morphology of microglia across contexts of health and disease. Springer, New York, pp 13\u201326"},{"issue":"4","key":"1550_CR93","doi-asserted-by":"publisher","DOI":"10.15252\/emmm.201911227","volume":"12","author":"K Schlepckow","year":"2020","unstructured":"Schlepckow K, Monroe KM, Kleinberger G, Cantuti-Castelvetri L, Parhizkar S, Xia D, Haass C (2020) Enhancing protective microglial activities with a dual function TREM2 antibody to the stalk region. EMBO Mol Med 12(4):e11227. https:\/\/doi.org\/10.15252\/emmm.201911227","journal-title":"EMBO Mol Med"},{"issue":"11","key":"1550_CR94","doi-asserted-by":"publisher","first-page":"778","DOI":"10.1016\/j.tins.2019.09.004","volume":"42","author":"A Sierra","year":"2019","unstructured":"Sierra A, Paolicelli RC, Kettenmann H (2019) Cien Anos de Microglia: milestones in a century of microglial research. Trends Neurosci 42(11):778\u2013792. https:\/\/doi.org\/10.1016\/j.tins.2019.09.004","journal-title":"Trends Neurosci"},{"issue":"9","key":"1550_CR95","doi-asserted-by":"publisher","first-page":"1373","DOI":"10.1038\/ng.3916","volume":"49","author":"R Sims","year":"2017","unstructured":"Sims R, Van Der Lee SJ, Naj AC, Bellenguez C, Badarinarayan N, Jakobsdottir J, ... Daniilidou M (2017) Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease.\u00a0Nat Genet\u00a049(9) 1373\u20131384. https:\/\/doi.org\/10.1038\/ng.3916","journal-title":"Nat Genet"},{"issue":"1","key":"1550_CR96","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s41232-023-00277-3","volume":"43","author":"A Sobue","year":"2023","unstructured":"Sobue A, Komine O, Yamanaka KJI (2023) Neuroinflammation in Alzheimer\u2019s disease: microglial signature and their relevance to disease. Inflamm Regen 43(1):1\u20136","journal-title":"Inflamm Regen"},{"issue":"13","key":"1550_CR97","doi-asserted-by":"publisher","first-page":"107843","DOI":"10.1016\/j.celrep.2020.107843","volume":"31","author":"K Srinivasan","year":"2020","unstructured":"Srinivasan K, Friedman BA, Etxeberria A, Huntley MA, van Der Brug MP, Foreman O, Serrano GEJC (2020) Alzheimer\u2019s patient microglia exhibit enhanced aging and unique transcriptional activation. Cell Rep 31(13):107843","journal-title":"Cell Rep"},{"issue":"6","key":"1550_CR98","doi-asserted-by":"publisher","first-page":"1673","DOI":"10.1016\/S0002-9440(10)65423-5","volume":"154","author":"M Stalder","year":"1999","unstructured":"Stalder M, Phinney A, Probst A, Sommer B, Staufenbiel M, Jucker M (1999) Association of microglia with amyloid plaques in brains of APP23 transgenic mice. The Am J Pathol 154(6):1673\u20131684","journal-title":"The Am J Pathol"},{"key":"1550_CR99","doi-asserted-by":"publisher","DOI":"10.1177\/1759091420925335","author":"M-K St-Pierre","year":"2020","unstructured":"St-Pierre M-K, \u0160imon\u010di\u010dov\u00e1 E, B\u00f6gi E, Tremblay M-\u00c8 (2020) Shedding light on the dark side of the microglia. ASN Neuro. https:\/\/doi.org\/10.1177\/1759091420925335","journal-title":"ASN Neuro"},{"issue":"17","key":"1550_CR100","doi-asserted-by":"publisher","first-page":"101997","DOI":"10.15252\/embj.2019101997","volume":"38","author":"V Stratoulias","year":"2019","unstructured":"Stratoulias V, Venero JL, Tremblay M\u00c8, Joseph B (2019) Microglial subtypes: diversity within the microglial community. The EMBO J 38(17):101997","journal-title":"The EMBO J"},{"issue":"1","key":"1550_CR101","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1186\/s12974-021-02182-3","volume":"18","author":"XY Sun","year":"2021","unstructured":"Sun XY, Li LJ, Dong QX, Zhu J, Huang YR, Hou SJ, Liu RT (2021) Rutin prevents tau pathology and neuroinflammation in a mouse model of Alzheimer\u2019s disease. J Neuroinflamm 18(1):131. https:\/\/doi.org\/10.1186\/s12974-021-02182-3","journal-title":"J Neuroinflamm"},{"key":"1550_CR102","doi-asserted-by":"publisher","DOI":"10.1002\/pmic.202200183","author":"S Sunna","year":"2023","unstructured":"Sunna S, Bowen CA, Ramelow CC, Santiago JV, Kumar P, Rangaraju SJP (2023) Advances in proteomic phenotyping of microglia in neurodegeneration. Proteomics. https:\/\/doi.org\/10.1002\/pmic.202200183","journal-title":"Proteomics"},{"issue":"3","key":"1550_CR103","doi-asserted-by":"publisher","first-page":"352","DOI":"10.1189\/jlb.0608385","volume":"85","author":"BR Tambuyzer","year":"2009","unstructured":"Tambuyzer BR, Ponsaerts P, Nouwen EJ (2009) Microglia: gatekeepers of central nervous system immunology. J Leukoc Biol 85(3):352\u2013370. https:\/\/doi.org\/10.1189\/jlb.0608385","journal-title":"J Leukoc Biol"},{"issue":"23","key":"1550_CR104","doi-asserted-by":"publisher","first-page":"13052","DOI":"10.3390\/ijms222313052","volume":"22","author":"RG Toedebusch","year":"2021","unstructured":"Toedebusch RG, Lucchesi CA, Debebe ET, Wittenburg LA, Chen X, Toedebusch CM (2021) Microglia-Derived Olfactomedin-like 3 Promotes Pro-Tumorigenic Microglial Function and Malignant Features of Glioma Cells.\u00a0Int J\u00a0Mol Sci\u00a022 (23):13052. https:\/\/doi.org\/10.3390\/ijms222313052","journal-title":"Int J Mol Sci"},{"issue":"4","key":"1550_CR105","doi-asserted-by":"publisher","first-page":"649","DOI":"10.1016\/j.cell.2017.07.023","volume":"170","author":"TK Ulland","year":"2017","unstructured":"Ulland TK, Song WM, Huang SC-C, Ulrich JD, Sergushichev A, Beatty WL, Kambal AJC (2017) TREM2 maintains microglial metabolic fitness in Alzheimer\u2019s disease. Cell 170(4):649\u2013663613","journal-title":"Cell"},{"key":"1550_CR106","doi-asserted-by":"publisher","first-page":"317","DOI":"10.3233\/JAD-230151","volume":"95","author":"MC Vicente","year":"2023","unstructured":"Vicente MC, Paneghini JL, Stabile AM, Amorim M, Anibal Silva CE, Patrone LGA, Gargaglioni LH (2023) Inhibition of pro-inflammatory microglia with minocycline improves cognitive and sleep-wake dysfunction under respiratory stress in a sporadic model for Alzheimer\u2019s Disease. J Alzheimers Dis 95:317\u2013337. https:\/\/doi.org\/10.3233\/JAD-230151","journal-title":"J Alzheimers Dis"},{"key":"1550_CR107","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1186\/1742-2094-9-27","volume":"9","author":"J Vinet","year":"2012","unstructured":"Vinet J, Weering HR, Heinrich A, K\u00e4lin RE, Wegner A, Brouwer N, Biber K (2012) Neuroprotective function for ramified microglia in hippocampal excitotoxicity. J Neuroinflamm 9:27. https:\/\/doi.org\/10.1186\/1742-2094-9-27","journal-title":"J Neuroinflamm"},{"key":"1550_CR108","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20200785","author":"S Wang","year":"2020","unstructured":"Wang S, Mustafa M, Yuede CM, Salazar SV, Kong P, Long H, Colonna M (2020) Anti-human TREM2 induces microglia proliferation and reduces pathology in an Alzheimer\u2019s disease model. J Exp Med. https:\/\/doi.org\/10.1084\/jem.20200785","journal-title":"J Exp Med"},{"key":"1550_CR109","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1117172","author":"C Wang","year":"2023","unstructured":"Wang C, Zong S, Cui X, Wang X, Wu S, Wang L, Lu Z (2023) The effects of microglia-associated neuroinflammation on Alzheimer\u2019s disease. Front Immunol. https:\/\/doi.org\/10.3389\/fimmu.2023.1117172","journal-title":"Front Immunol"},{"issue":"1","key":"1550_CR110","doi-asserted-by":"publisher","first-page":"489456","DOI":"10.1155\/2012\/489456","volume":"2012","author":"K Wilkinson","year":"2012","unstructured":"Wilkinson K, El Khoury J (2012) Microglial scavenger receptors and their roles in the pathogenesis of Alzheimer\u2019s disease. Int J of Alzheimer\u2019s Dis 2012(1):489456. https:\/\/doi.org\/10.1155\/2012\/489456","journal-title":"Int J of Alzheimer\u2019s Dis"},{"issue":"1","key":"1550_CR111","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1002\/glia.20585","volume":"56","author":"JR Weinstein","year":"2008","unstructured":"Weinstein JR, Swarts S, Bishop C, Hanisch UK, M\u00f6ller TJG (2008) Lipopolysaccharide is a frequent and significant contaminant in microglia-activating factors. Glia 56(1):16\u201326","journal-title":"Glia"},{"issue":"2","key":"1550_CR112","doi-asserted-by":"publisher","first-page":"397","DOI":"10.3233\/JAD-150745","volume":"50","author":"R Weissmann","year":"2016","unstructured":"Weissmann R, H\u00fcttenrauch M, Kacprowski T, Bouter Y, Pradier L, Bayer TA, Wirths O (2016) Gene expression profiling in the APP\/PS1KI mouse model of familial Alzheimer\u2019s disease. J Alzheimer\u2019s Disease 50(2):397\u2013409","journal-title":"J Alzheimer's Disease"},{"key":"1550_CR113","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1016\/j.pneurobio.2016.05.001","volume":"142","author":"XY Xiong","year":"2016","unstructured":"Xiong XY, Liu L, Yang QW (2016) Functions and mechanisms of microglia\/macrophages in neuroinflammation and neurogenesis after stroke. Prog Neurobiol 142:23\u201344. https:\/\/doi.org\/10.1016\/j.pneurobio.2016.05.001","journal-title":"Prog Neurobiol"},{"key":"1550_CR114","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1016\/j.redox.2018.03.002","volume":"16","author":"J-L Yang","year":"2018","unstructured":"Yang J-L, Mukda S, Chen S-DJR (2018) Diverse roles of mitochondria in ischemic stroke. Redox Biol 16:263\u2013275","journal-title":"Redox Biol"},{"key":"1550_CR115","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.55564","author":"X Yang","year":"2020","unstructured":"Yang X, Zhao L, Campos MM, Abu-Asab M, Ortolan D, Hotaling N, Wong WT (2020) CSF1R blockade induces macrophage ablation and results in mouse choroidal vascular atrophy and RPE disorganization. Elife. https:\/\/doi.org\/10.7554\/eLife.55564","journal-title":"Elife"},{"issue":"2","key":"1550_CR116","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1016\/j.molmed.2018.11.004","volume":"25","author":"H Yeh","year":"2019","unstructured":"\u00a0Yeh H, Ikezu T (2019) Transcriptional and epigenetic regulation of microglia in health and disease. Trends in molecular medicine 25(2):96\u2013111. https:\/\/doi.org\/10.1016\/j.molmed.2018.11.004","journal-title":"Trends in molecular medicine"},{"key":"1550_CR117","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1016\/j.neurobiolaging.2017.03.021","volume":"55","author":"Z Yin","year":"2017","unstructured":"Yin Z, Raj D, Saiepour N, Van Dam D, Brouwer N, Holtman IR, Boddeke E (2017) Immune hyperreactivity of A\u03b2 plaque-associated microglia in Alzheimer\u2019s disease. Neurobiol Aging 55:115\u2013122. https:\/\/doi.org\/10.1016\/j.neurobiolaging.2017.03.021","journal-title":"Neurobiol Aging"},{"issue":"1","key":"1550_CR118","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1186\/s13024-022-00550-y","volume":"17","author":"P Zhao","year":"2022","unstructured":"Zhao P, Xu Y, Jiang LL, Fan X, Ku Z, Li L, An Z (2022) LILRB2-mediated TREM2 signaling inhibition suppresses microglia functions. Mol Neurodegener 17(1):44. https:\/\/doi.org\/10.1186\/s13024-022-00550-y","journal-title":"Mol Neurodegener"}],"container-title":["Inflammopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10787-024-01550-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10787-024-01550-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10787-024-01550-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,21]],"date-time":"2024-09-21T17:05:13Z","timestamp":1726938313000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10787-024-01550-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8,21]]},"references-count":119,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2024,10]]}},"alternative-id":["1550"],"URL":"https:\/\/doi.org\/10.1007\/s10787-024-01550-8","relation":{},"ISSN":["0925-4692","1568-5608"],"issn-type":[{"value":"0925-4692","type":"print"},{"value":"1568-5608","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,8,21]]},"assertion":[{"value":"27 June 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"31 July 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 August 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors have no relevant financial interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interests"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}}]}}